Helen Hobbs - Publications

Affiliations: 
University of Texas Southwestern Medical Center, Dallas, TX, United States 

145 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Sun Y, Wang J, Long T, Qi X, Donnelly L, Elghobashi-Meinhardt N, Esparza L, Cohen JC, Xie XS, Hobbs HH, Li X. Molecular basis of cholesterol efflux via ABCG subfamily transporters. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34404721 DOI: 10.1073/pnas.2110483118  1
2021 Luo F, Xing C, Asrani S, Li S, Liang G, Hobbs HH, Cohen JC. Missense Variant in Insulin Receptor (Y1355H) Segregates in Family with Fatty Liver Disease. Molecular Metabolism. 101299. PMID 34271222 DOI: 10.1016/j.molmet.2021.101299  1
2021 Oldoni F, Bass K, Kozlitina J, Hudson H, Shihanian LM, Gusarova V, Cohen JC, Hobbs HH. Genetic and Metabolic Determinants of Plasma Levels of ANGPTL8. The Journal of Clinical Endocrinology and Metabolism. PMID 33619548 DOI: 10.1210/clinem/dgab120  1
2020 Roberts F, Hobbs H, Jessop H, Bozzolini C, Burman J, Greco R, Ismail A, Kazmi M, Kirgizov K, Mancardi G, Mawson S, Muraro PA, Puyade M, Saccardi R, Withers B, et al. Rehabilitation Before and After Autologous Haematopoietic Stem Cell Transplantation (AHSCT) for Patients With Multiple Sclerosis (MS): Consensus Guidelines and Recommendations for Best Clinical Practice on Behalf of the Autoimmune Diseases Working Party, Nurses Group, and Patient Advocacy Committee of the European Society for Blood and Marrow Transplantation (EBMT). Frontiers in Neurology. 11: 556141. PMID 33362684 DOI: 10.3389/fneur.2020.556141  0.01
2020 Oldoni F, Cheng H, Banfi S, Gusarova V, Cohen JC, Hobbs HH. ANGPTL8 has both endocrine and autocrine effects on substrate utilization. Jci Insight. PMID 32730227 DOI: 10.1172/jci.insight.138777  1
2020 Adam RC, Mintah IJ, Alexa-Braun CA, Shihanian LM, Lee JS, Banerjee P, Hamon SC, Kim HI, Cohen JC, Hobbs HH, Van Hout C, Gromada J, Murphy AJ, Yancopoulos GD, Sleeman MW, et al. Angiopoietin-like protein 3 (ANGPTL3) governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance. Journal of Lipid Research. PMID 32646941 DOI: 10.1194/jlr.RA120000888  1
2019 Faulkner J, Martinelli L, Cook K, Stoner L, Ryan-Stewart H, Paine E, Hobbs H, Lambrick D. Effects of robotic-assisted gait training on the central vascular health of individuals with spinal cord injury: A pilot study. The Journal of Spinal Cord Medicine. 1-7. PMID 31525137 DOI: 10.1080/10790268.2019.1656849  1
2019 BasuRay S, Wang Y, Smagris E, Cohen JC, Hobbs HH. Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 31019090 DOI: 10.1073/pnas.1901974116  1
2019 Wang Y, Kory N, Cohen JC, Hobbs HH. PNPLA3, CGI-58, and Inhibition of Hepatic Triglyceride Hydrolysis in Mice. Hepatology (Baltimore, Md.). PMID 30802989 DOI: 10.1002/Hep.30583  1
2018 Kozlitina J, Stender S, Hobbs HH, Cohen JC. HSD17B13 and Chronic Liver Disease in Blacks and Hispanics. The New England Journal of Medicine. 379: 1876-1877. PMID 30403941 DOI: 10.1056/Nejmc1804027  1
2018 Hobbs HH. Science, serendipity, and the single degree. The Journal of Clinical Investigation. 128: 4218-4223. PMID 30272579 DOI: 10.1172/JCI124404  0.01
2018 Mitsche MA, Hobbs HH, Cohen JC. Patatin-like phospholipase domain-containing protein 3 promotes transfers of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets. The Journal of Biological Chemistry. 293: 9232. PMID 29907731 DOI: 10.1074/jbc.AAC118.004058  1
2018 Abul-Husn NS, Cheng X, Li AH, Xin Y, Schurmann C, Stevis P, Liu Y, Kozlitina J, Stender S, Wood GC, Stepanchick AN, Still MD, McCarthy S, O'Dushlaine C, Packer JS, ... ... Hobbs HH, et al. A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease. The New England Journal of Medicine. 378: 1096-1106. PMID 29562163 DOI: 10.1056/Nejmoa1712191  1
2018 Mitsche MA, Hobbs HH, Cohen JC. Phospholipase Domain-containing Protein 3 Promotes Transfers of Essential Fatty Acids from Triglycerides to Phospholipids in Hepatic Lipid Droplets. The Journal of Biological Chemistry. PMID 29555681 DOI: 10.1074/jbc.RA118.002333  1
2018 Amacher JF, Hobbs HT, Cantor AC, Shah L, Rivero MJ, Mulchand SA, Kuriyan J. Phosphorylation Control of the Ubiquitin Ligase Cbl is Conserved in Choanoflagellates. Protein Science : a Publication of the Protein Society. PMID 29498112 DOI: 10.1002/Pro.3397  0.01
2018 Banfi S, Gusarova V, Gromada J, Cohen JC, Hobbs HH. Increased thermogenesis by a noncanonical pathway in ANGPTL3/8-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 29358393 DOI: 10.1073/pnas.1717420115  1
2017 Wright A, Stone K, Lambrick D, Fryer S, Stoner L, Tasker E, Jobson S, Smith G, Batten J, Batey J, Hudson V, Hobbs H, Faulkner J. A Community-Based, Bionic Leg Rehabilitation Program for Patients with Chronic Stroke: Clinical Trial Protocol. Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association. PMID 29097056 DOI: 10.1016/J.Jstrokecerebrovasdis.2017.09.002  1
2017 BasuRay S, Smagris E, Cohen JC, Hobbs HH. The PNPLA3 Variant Associated with Fatty Liver Disease (I148M) Accumulates on Lipid Droplets by Evading Ubiquitylation. Hepatology (Baltimore, Md.). PMID 28520213 DOI: 10.1002/hep.29273  1
2017 Stender S, Kozlitina J, Nordestgaard BG, Tybjærg-Hansen A, Hobbs HH, Cohen JC. Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci. Nature Genetics. PMID 28436986 DOI: 10.1038/Ng.3855  1
2017 Haller JF, Mintah IJ, Shihanian LM, Stevis P, Buckler D, Alexa-Braun CA, Kleiner S, Banfi S, Cohen JC, Hobbs HH, Yancopoulos GD, Murphy AJ, Gusarova V, Gromada J. ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance. Journal of Lipid Research. PMID 28413163 DOI: 10.1194/Jlr.M075689  1
2017 Gusarova V, Banfi S, Alexa-Braun CA, Shihanian LM, Mintah IJ, Lee JS, Xin Y, Su Q, Kamat V, Cohen JC, Hobbs HH, Zambrowicz B, Yancopoulos GD, Murphy AJ, Gromada J. ANGPTL8 Blockade With a Monoclonal Antibody Promotes Triglyceride Clearance, Energy Expenditure and Weight Loss in Mice. Endocrinology. PMID 28204173 DOI: 10.1210/En.2016-1894  1
2017 Chakrabarti RS, Ingham SA, Kozlitina J, Gay A, Cohen JC, Radhakrishnan A, Hobbs HH. Variability of cholesterol accessibility in human red blood cells measured using a bacterial cholesterol-binding toxin. Elife. 6. PMID 28169829 DOI: 10.7554/Elife.23355  1
2016 Lee JY, Kinch LN, Borek DM, Wang J, Wang J, Urbatsch IL, Xie XS, Grishin NV, Cohen JC, Otwinowski Z, Hobbs HH, Rosenbaum DM. Crystal structure of the human sterol transporter ABCG5/ABCG8. Nature. PMID 27144356 DOI: 10.1038/Nature17666  1
2016 Smagris E, Gilyard S, BasuRay S, Cohen JC, Hobbs HH. Inactivation of Tm6sf2, a Gene Defective in Fatty Liver Disease, Impairs Lipidation but not Secretion of Very Low Density Lipoproteins. The Journal of Biological Chemistry. PMID 27013658 DOI: 10.1074/jbc.M116.719955  1
2016 Smagris E, Basuray S, Gromada J, Cohen JC, Hobbs HH. Reply Hepatology. 63: 677. PMID 26099489 DOI: 10.1002/hep.27945  1
2015 Stender S, Chakrabarti RS, Xing C, Gotway G, Cohen JC, Hobbs HH. Adult-onset liver disease and hepatocellular carcinoma in S-adenosylhomocysteine hydrolase deficiency. Molecular Genetics and Metabolism. PMID 26527160 DOI: 10.1016/j.ymgme.2015.10.009  1
2015 Hobbs H, Neill US. A conversation with Helen Hobbs. The Journal of Clinical Investigation. 125: 3725-6. PMID 26426073 DOI: 10.1172/JCI84086  0.04
2015 Wang Y, McNutt MC, Banfi S, Levin MG, Holland WL, Gusarova V, Gromada J, Cohen JC, Hobbs HH. Hepatic ANGPTL3 regulates adipose tissue energy homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 112: 11630-5. PMID 26305978 DOI: 10.1073/pnas.1515374112  1
2015 Mitsche MA, McDonald JG, Hobbs HH, Cohen JC. Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways. Elife. 4. PMID 26114596 DOI: 10.7554/Elife.07999  1
2015 Gusarova V, Alexa CA, Wang Y, Rafique A, Kim JH, Buckler D, Mintah IJ, Shihanian LM, Cohen JC, Hobbs HH, Xin Y, Valenzuela DM, Murphy AJ, Yancopoulos GD, Gromada J. ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys. Journal of Lipid Research. 56: 1308-17. PMID 25964512 DOI: 10.1194/jlr.M054890  1
2015 Wang Y, Gusarova V, Banfi S, Gromada J, Cohen JC, Hobbs HH. Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion. Journal of Lipid Research. 56: 1296-307. PMID 25954050 DOI: 10.1194/jlr.M054882  1
2015 Wang J, Mitsche MA, Lütjohann D, Cohen JC, Xie XS, Hobbs HH. Relative roles of ABCG5/ABCG8 in liver and intestine. Journal of Lipid Research. 56: 319-30. PMID 25378657 DOI: 10.1194/jlr.M054544  1
2015 Smagris E, BasuRay S, Li J, Huang Y, Lai KM, Gromada J, Cohen JC, Hobbs HH. Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis. Hepatology (Baltimore, Md.). 61: 108-18. PMID 24917523 DOI: 10.1002/hep.27242  1
2015 Gusarova V, Alexa CA, Wang Y, Rafique A, Kim JH, Buckler D, Mintah IJ, Shihanian LM, Cohen JC, Hobbs HH, Xin Y, Valenzuela DM, Murphy AJ, Yancopoulos GD, Gromada J. ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys Journal of Lipid Research. 56: 1308-1317. DOI: 10.1194/jlr.M054890  1
2015 Wang Y, Gusarova V, Banfi S, Gromada J, Cohen JC, Hobbs HH. Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion Journal of Lipid Research. 56: 1296-1307. DOI: 10.1194/jlr.M054882  1
2014 Hobbs H, Bassett P, Wheeler T, Bedford M, Irving J, Stevens PE, Farmer CK. Do acute elevations of serum creatinine in primary care engender an increased mortality risk? Bmc Nephrology. 15: 206. PMID 25535396 DOI: 10.1186/1471-2369-15-206  1
2014 Gusarova V, Alexa CA, Na E, Stevis PE, Xin Y, Bonner-Weir S, Cohen JC, Hobbs HH, Murphy AJ, Yancopoulos GD, Gromada J. ANGPTL8/betatrophin does not control pancreatic beta cell expansion. Cell. 159: 691-6. PMID 25417115 DOI: 10.1016/j.cell.2014.09.027  1
2014 Cohen JC, Stender S, Hobbs HH. APOC3, coronary disease, and complexities of Mendelian randomization. Cell Metabolism. 20: 387-9. PMID 25185943 DOI: 10.1016/j.cmet.2014.08.007  1
2014 Kozlitina J, Smagris E, Stender S, Nordestgaard BG, Zhou HH, Tybjærg-Hansen A, Vogt TF, Hobbs HH, Cohen JC. Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease. Nature Genetics. 46: 352-6. PMID 24531328 DOI: 10.1038/Ng.2901  1
2013 Wang Y, Quagliarini F, Gusaroèa E, Gromada J, Èalenzuela DM, Cohen JC, Hobbs HH. Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis Proceedings of the National Academy of Sciences of the United States of America. 110: 16109-16114. PMID 24043787 DOI: 10.1073/pnas.1315292110  1
2013 Cohen JC, Hobbs HH. Simple genetics for a complex disease Science. 340: 689-690. PMID 23661745 DOI: 10.1126/science.1239101  1
2013 Karunaratne K, Stevens P, Irving J, Hobbs H, Kilbride H, Kingston R, Farmer C. The impact of pay for performance on the control of blood pressure in people with chronic kidney disease stage 3-5. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 28: 2107-16. PMID 23658247 DOI: 10.1093/ndt/gft093  1
2012 Quagliarini F, Wang Y, Kozlitina J, Grishin NV, Hyde R, Boerwinkle E, Valenzuela DM, Murphy AJ, Cohen JC, Hobbs HH. Atypical angiopoietin-like protein that regulates ANGPTL3. Proceedings of the National Academy of Sciences of the United States of America. 109: 19751-6. PMID 23150577 DOI: 10.1073/Pnas.1217552109  1
2012 Li JZ, Huang Y, Karaman R, Ivanova PT, Brown HA, Roddy T, Castro-Perez J, Cohen JC, Hobbs HH. Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis. The Journal of Clinical Investigation. 122: 4130-44. PMID 23023705 DOI: 10.1172/JCI65179  1
2012 Wang Y, Huang Y, Hobbs HH, Cohen JC. Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR. Journal of Lipid Research. 53: 1932-43. PMID 22764087 DOI: 10.1194/jlr.M028563  1
2012 Molho-Pessach V, Rios JJ, Xing C, Setchell KD, Cohen JC, Hobbs HH. Homozygosity mapping identifies a bile acid biosynthetic defect in an adult with cirrhosis of unknown etiology. Hepatology (Baltimore, Md.). 55: 1139-45. PMID 22095780 DOI: 10.1002/Hep.24781  1
2012 Rios JJ, Shastry S, Jasso J, Hauser N, Garg A, Bensadoun A, Cohen JC, Hobbs HH. Deletion of GPIHBP1 causing severe chylomicronemia Journal of Inherited Metabolic Disease. 35: 531-540. PMID 22008945 DOI: 10.1007/S10545-011-9406-5  1
2012 Li Y, Xing C, Cohen JC, Hobbs HH. Genetic variant in PNPLA3 is associated with nonalcoholic fatty liver disease in China Hepatology. 55: 327-328. PMID 21898508 DOI: 10.1002/hep.24659  1
2011 Huang Y, Cohen JC, Hobbs HH. Expression and characterization of a PNPLA3 protein isoform (I148M) associated with nonalcoholic fatty liver disease. The Journal of Biological Chemistry. 286: 37085-93. PMID 21878620 DOI: 10.1074/jbc.M111.290114  1
2011 Hobbs H, Farmer C, Irving J, Klebe B, Stevens P. Is high body mass index independently associated with diminished glomerular filtration rate? An epidemiological study. Journal of Renal Care. 37: 148-54. PMID 21810196 DOI: 10.1111/j.1755-6686.2011.00231.x  1
2011 Cohen JC, Horton JD, Hobbs HH. Human fatty liver disease: old questions and new insights. Science (New York, N.Y.). 332: 1519-23. PMID 21700865 DOI: 10.1126/science.1204265  1
2011 Ramirez R, Cohen JC, Hobbs HH, Browning JD. Hepatic triglyceride content in individuals with reduced intestinal cholesterol absorption due to variants in Nieman Pick C1-like 1. Hepatology (Baltimore, Md.). 54: 736-7. PMID 21626528 DOI: 10.1002/hep.24461  1
2011 Kozlitina J, Boerwinkle E, Cohen JC, Hobbs HH. Dissociation between APOC3 variants, hepatic triglyceride content and insulin resistance. Hepatology (Baltimore, Md.). 53: 467-74. PMID 21274868 DOI: 10.1002/Hep.24072  1
2011 Wang J, Grishin N, Kinch L, Cohen JC, Hobbs HH, Xie XS. Sequences in the nonconsensus nucleotide-binding domain of ABCG5/ABCG8 required for sterol transport. The Journal of Biological Chemistry. 286: 7308-14. PMID 21209088 DOI: 10.1074/Jbc.M110.210880  1
2010 Musunuru K, Pirruccello JP, Do R, Peloso GM, Guiducci C, Sougnez C, Garimella KV, Fisher S, Abreu J, Barry AJ, Fennell T, Banks E, Ambrogio L, Cibulskis K, Kernytsky A, ... ... Hobbs HH, et al. Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia. The New England Journal of Medicine. 363: 2220-7. PMID 20942659 DOI: 10.1056/Nejmoa1002926  1
2010 Browning JD, Cohen JC, Hobbs HH. Patatin-like phospholipase domain-containing 3 and the pathogenesis and progression of pediatric nonalcoholic fatty liver disease Hepatology (Baltimore, Md.). 52: 1189-1192. PMID 20879029 DOI: 10.1002/hep.23946  1
2010 Rios J, Stein E, Shendure J, Hobbs HH, Cohen JC. Identification by whole-genome resequencing of gene defect responsible for severe hypercholesterolemia. Human Molecular Genetics. 19: 4313-8. PMID 20719861 DOI: 10.1093/Hmg/Ddq352  1
2010 Huang Y, He S, Li JZ, Seo YK, Osborne TF, Cohen JC, Hobbs HH. A feed-forward loop amplifies nutritional regulation of PNPLA3. Proceedings of the National Academy of Sciences of the United States of America. 107: 7892-7. PMID 20385813 DOI: 10.1073/Pnas.1003585107  1
2010 He S, McPhaul C, Li JZ, Garuti R, Kinch L, Grishin NV, Cohen JC, Hobbs HH. A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis. The Journal of Biological Chemistry. 285: 6706-15. PMID 20034933 DOI: 10.1074/Jbc.M109.064501  1
2010 Lakoski SG, Xu F, Vega GL, Grundy SM, Chandalia M, Lam C, Lowe RS, Stepanavage ME, Musliner TA, Cohen JC, Hobbs HH. Indices of cholesterol metabolism and relative responsiveness to ezetimibe and simvastatin. The Journal of Clinical Endocrinology and Metabolism. 95: 800-9. PMID 19965915 DOI: 10.1210/jc.2009-1952  1
2009 Hobbs H, Stevens P, Klebe B, Irving J, Cooley R, O'Donoghue D, Green S, Farmer C. Referral patterns to renal services: what has changed in the past 4 years? Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 24: 3411-9. PMID 19535434 DOI: 10.1093/ndt/gfp289  1
2009 Lakoski SG, Lagace TA, Cohen JC, Horton JD, Hobbs HH. Genetic and metabolic determinants of plasma PCSK9 levels. The Journal of Clinical Endocrinology and Metabolism. 94: 2537-43. PMID 19351729 DOI: 10.1210/Jc.2009-0141  1
2009 Yin W, Romeo S, Chang S, Grishin NV, Hobbs HH, Cohen JC. Genetic variation in ANGPTL4 provides insights into protein processing and function. The Journal of Biological Chemistry. 284: 13213-22. PMID 19270337 DOI: 10.1074/Jbc.M900553200  1
2009 Romeo S, Yin W, Kozlitina J, Pennacchio LA, Boerwinkle E, Hobbs HH, Cohen JC. Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans. The Journal of Clinical Investigation. 119: 70-9. PMID 19075393 DOI: 10.1172/Jci37118  1
2009 Horton JD, Cohen JC, Hobbs HH. PCSK9: a convertase that coordinates LDL catabolism. Journal of Lipid Research. 50: S172-7. PMID 19020338 DOI: 10.1194/jlr.R800091-JLR200  1
2008 Romeo S, Kozlitina J, Xing C, Pertsemlidis A, Cox D, Pennacchio LA, Boerwinkle E, Cohen JC, Hobbs HH. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nature Genetics. 40: 1461-5. PMID 18820647 DOI: 10.1038/Ng.257  1
2008 Zhang DW, Garuti R, Tang WJ, Cohen JC, Hobbs HH. Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor Proceedings of the National Academy of Sciences of the United States of America. 105: 13045-13050. PMID 18753623 DOI: 10.1073/pnas.0806312105  1
2008 Fahmi S, Yang C, Esmail S, Hobbs HH, Cohen JC. Functional characterization of genetic variants in NPC1L1 supports the sequencing extremes strategy to identify complex trait genes Human Molecular Genetics. 17: 2101-2107. PMID 18413323 DOI: 10.1093/hmg/ddn108  1
2008 Wang J, Zhang DW, Lei Y, Xu F, Cohen JC, Hobbs HH, Xie XS. Purification and reconstitution of sterol transfer by native mouse ABCG5 and ABCG8. Biochemistry. 47: 5194-204. PMID 18402465 DOI: 10.1021/bi800292v  1
2008 Adkins SS, Hobbs HR, Benaissi K, Johnston KP, Poliakoff M, Thomas NR. Stable colloidal dispersions of a lipase-perfluoropolyether complex in liquid and supercritical carbon dioxide. The Journal of Physical Chemistry. B. 112: 4760-9. PMID 18363394 DOI: 10.1021/Jp076930N  1
2007 Hobbs HR, Kirke HM, Poliakoff M, Thomas NR. Homogeneous biocatalysis in both fluorous biphasic and supercritical carbon dioxide systems. Angewandte Chemie (International Ed. in English). 46: 7860-3. PMID 17823904 DOI: 10.1002/Anie.200701488  1
2007 Michaely P, Zhao Z, Li WP, Garuti R, Huang LJ, Hobbs HH, Cohen JC. Identification of a VLDL-induced, FDNPVY-independent internalization mechanism for the LDLR. The Embo Journal. 26: 3273-82. PMID 17581630 DOI: 10.1038/sj.emboj.7601769  1
2007 Hobbs HR, Thomas NR. Biocatalysis in supercritical fluids, in fluorous solvents, and under solvent-free conditions. Chemical Reviews. 107: 2786-820. PMID 17564485 DOI: 10.1021/Cr0683820  1
2007 Klebe B, Irving J, Stevens PE, O'Donoghue DJ, de Lusignan S, Cooley R, Hobbs H, Lamb EJ, John I, Middleton R, New J, Farmer CKT. The cost of implementing UK guidelines for the management of chronic kidney disease Nephrology Dialysis Transplantation. 22: 2504-2512. PMID 17550923 DOI: 10.1093/ndt/gfm248  1
2007 McPherson R, Pertsemlidis A, Kavaslar N, Stewart A, Roberts R, Cox DR, Hinds DA, Pennacchio LA, Tybjaerg-Hansen A, Folsom AR, Boerwinkle E, Hobbs HH, Cohen JC. A common allele on chromosome 9 associated with coronary heart disease. Science (New York, N.Y.). 316: 1488-91. PMID 17478681 DOI: 10.1126/science.1142447  1
2007 Zhang DW, Lagace TA, Garuti R, Zhao Z, McDonald M, Horton JD, Cohen JC, Hobbs HH. Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation. The Journal of Biological Chemistry. 282: 18602-12. PMID 17452316 DOI: 10.1074/Jbc.M702027200  1
2007 Romeo S, Pennacchio LA, Fu Y, Boerwinkle E, Tybjaerg-Hansen A, Hobbs HH, Cohen JC. Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL. Nature Genetics. 39: 513-6. PMID 17322881 DOI: 10.1038/Ng1984  1
2007 Horton JD, Cohen JC, Hobbs HH. Molecular biology of PCSK9: its role in LDL metabolism Trends in Biochemical Sciences. 32: 71-77. PMID 17215125 DOI: 10.1016/j.tibs.2006.12.008  1
2007 Jones C, Garuti R, Michaely P, Li WP, Maeda N, Cohen JC, Herz J, Hobbs HH. Disruption of LDL but not VLDL clearance in autosomal recessive hypercholesterolemia. The Journal of Clinical Investigation. 117: 165-74. PMID 17200716 DOI: 10.1172/Jci29415  1
2006 Romeo S, Cohen JC, Hobbs HH. No association between polymorphism in PEMT (V175M) and hepatic triglyceride content in the Dallas Heart Study [1] Faseb Journal. 20: 2180. PMID 17012264 DOI: 10.1096/fj.06-1004ufm  1
2006 Zhao Z, Tuakli-Wosornu Y, Lagace TA, Kinch L, Grishin NV, Horton JD, Cohen JC, Hobbs HH. Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote American Journal of Human Genetics. 79: 514-523. PMID 16909389 DOI: 10.1086/507488  1
2006 Wang J, Sun F, Zhang DW, Ma Y, Xu F, Belani JD, Cohen JC, Hobbs HH, Xie XS. Sterol transfer by ABCG5 and ABCG8: in vitro assay and reconstitution. The Journal of Biological Chemistry. 281: 27894-904. PMID 16867993 DOI: 10.1074/Jbc.M605603200  1
2006 Yang C, McDonald JG, Patel A, Zhang Y, Umetani M, Xu F, Westover EJ, Covey DF, Mangelsdorf DJ, Cohen JC, Hobbs HH. Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. The Journal of Biological Chemistry. 281: 27816-26. PMID 16857673 DOI: 10.1074/Jbc.M603781200  1
2006 Cohen JC, Boerwinkle E, Mosley TH, Hobbs HH. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease New England Journal of Medicine. 354: 1264-1272. PMID 16554528 DOI: 10.1056/Nejmoa054013  1
2006 Kotowski IK, Pertsemlidis A, Luke A, Cooper RS, Vega GL, Cohen JC, Hobbs HH. A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol. American Journal of Human Genetics. 78: 410-22. PMID 16465619 DOI: 10.1086/500615  1
2006 Cohen JC, Pertsemlidis A, Fahmi S, Esmail S, Vega GL, Grundy SM, Hobbs HH. Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels. Proceedings of the National Academy of Sciences of the United States of America. 103: 1810-5. PMID 16449388 DOI: 10.1073/pnas.0508483103  1
2006 Yi M, Horton JD, Cohen JC, Hobbs HH, Stephens RM. WholePathwayScope: a comprehensive pathway-based analysis tool for high-throughput data. Bmc Bioinformatics. 7: 30. PMID 16423281 DOI: 10.1186/1471-2105-7-30  1
2006 Zhang DW, Graf GA, Gerard RD, Cohen JC, Hobbs HH. Functional asymmetry of nucleotide-binding domains in ABCG5 and ABCG8 Journal of Biological Chemistry. 281: 4507-4516. PMID 16352607 DOI: 10.1074/Jbc.M512277200  1
2005 Xu F, Rychnovsky SD, Belani JD, Hobbs HH, Cohen JC, Rawson RB. Dual roles for cholesterol in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 102: 14551-6. PMID 16199524 DOI: 10.1073/Pnas.0503590102  1
2005 Garuti R, Jones C, Li WP, Michaely P, Herz J, Gerard RD, Cohen JC, Hobbs HH. The modular adaptor protein autosomal recessive hypercholesterolemia (ARH) promotes low density lipoprotein receptor clustering into clathrin-coated pits. The Journal of Biological Chemistry. 280: 40996-1004. PMID 16179341 DOI: 10.1074/Jbc.M509394200  1
2005 Moschetta A, Xu F, Hagey LR, van Berge-Henegouwen GP, van Erpecum KJ, Brouwers JF, Cohen JC, Bierman M, Hobbs HH, Steinbach JH, Hofmann AF. A phylogenetic survey of biliary lipids in vertebrates. Journal of Lipid Research. 46: 2221-32. PMID 16061950 DOI: 10.1194/jlr.M500178-JLR200  1
2005 Langheim S, Yu L, von Bergmann K, Lütjohann D, Xu F, Hobbs HH, Cohen JC. ABCG5 and ABCG8 require MDR2 for secretion of cholesterol into bile. Journal of Lipid Research. 46: 1732-8. PMID 15930516 DOI: 10.1194/Jlr.M500115-Jlr200  1
2005 Yu L, von Bergmann K, Lütjohann D, Hobbs HH, Cohen JC. Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8. Journal of Lipid Research. 46: 1739-44. PMID 15930515 DOI: 10.1194/Jlr.M500124-Jlr200  1
2005 Hobbs H. Helen Hobbs, MD. Journal of Investigative Medicine : the Official Publication of the American Federation For Clinical Research. 53: 99-102. PMID 15921028 DOI: 10.2310/6650.2005.00301  0.01
2005 Guerra R, Yu Z, Marcovina S, Peshock R, Cohen JC, Hobbs HH. Lipoprotein(a) and apolipoprotein(a) isoforms: no association with coronary artery calcification in the Dallas Heart Study. Circulation. 111: 1471-9. PMID 15781743 DOI: 10.1161/01.Cir.0000159263.50305.Bd  1
2005 Cohen J, Pertsemlidis A, Kotowski IK, Graham R, Garcia CK, Hobbs HH. Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nature Genetics. 37: 161-5. PMID 15654334 DOI: 10.1038/ng1509  1
2005 Yu L, Gupta S, Xu F, Liverman AD, Moschetta A, Mangelsdorf DJ, Repa JJ, Hobbs HH, Cohen JC. Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion. The Journal of Biological Chemistry. 280: 8742-7. PMID 15611112 DOI: 10.1074/Jbc.M411080200  1
2005 Szczepaniak LS, Nurenberg P, Leonard D, Browning JD, Reingold JS, Grundy S, Hobbs HH, Dobbins RL. Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. American Journal of Physiology. Endocrinology and Metabolism. 288: E462-8. PMID 15339742 DOI: 10.1152/ajpendo.00064.2004  1
2004 Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Cohen JC, Grundy SM, Hobbs HH. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology (Baltimore, Md.). 40: 1387-95. PMID 15565570 DOI: 10.1002/hep.20466  1
2004 Wilund KR, Yu L, Xu F, Vega GL, Grundy SM, Cohen JC, Hobbs HH. No association between plasma levels of plant sterols and atherosclerosis in mice and men. Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 2326-32. PMID 15514206 DOI: 10.1161/01.Atv.0000149140.00499.92  1
2004 Yang C, Yu L, Li W, Xu F, Cohen JC, Hobbs HH. Disruption of cholesterol homeostasis by plant sterols. The Journal of Clinical Investigation. 114: 813-22. PMID 15372105 DOI: 10.1172/Jci22186  1
2004 Jain T, Peshock R, McGuire DK, Willett D, Yu Z, Yu Z, Vega GL, Guerra R, Hobbs HH, Grundy SM. African Americans and Caucasians have a similar prevalence of coronary calcium in the Dallas Heart Study. Journal of the American College of Cardiology. 44: 1011-7. PMID 15337212 DOI: 10.1016/J.Jacc.2004.05.069  1
2004 Cohen JC, Kiss RS, Pertsemlidis A, Marcel YL, McPherson R, Hobbs HH. Multiple rare alleles contribute to low plasma levels of HDL cholesterol. Science (New York, N.Y.). 305: 869-72. PMID 15297675 DOI: 10.1126/Science.1099870  1
2004 Victor RG, Haley RW, Willett DL, Peshock RM, Vaeth PC, Leonard D, Basit M, Cooper RS, Iannacchione VG, Visscher WA, Staab JM, Hobbs HH. The Dallas Heart Study: a population-based probability sample for the multidisciplinary study of ethnic differences in cardiovascular health. The American Journal of Cardiology. 93: 1473-80. PMID 15194016 DOI: 10.1016/j.amjcard.2004.02.058  1
2004 Wilund KR, Yu L, Xu F, Hobbs HH, Cohen JC. High-level expression of ABCG5 and ABCG8 attenuates diet-induced hypercholesterolemia and atherosclerosis in Ldlr-/- mice. Journal of Lipid Research. 45: 1429-36. PMID 15175362 DOI: 10.1194/Jlr.M400167-Jlr200  1
2004 Michaely P, Li WP, Anderson RG, Cohen JC, Hobbs HH. The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits. The Journal of Biological Chemistry. 279: 34023-31. PMID 15166224 DOI: 10.1074/jbc.M405242200  1
2004 Graf GA, Cohen JC, Hobbs HH. Missense mutations in ABCG5 and ABCG8 disrupt heterodimerization and trafficking. The Journal of Biological Chemistry. 279: 24881-8. PMID 15054092 DOI: 10.1074/Jbc.M402634200  1
2004 Yu L, von Bergmann K, Lutjohann D, Hobbs HH, Cohen JC. Selective sterol accumulation in ABCG5/ABCG8-deficient mice. Journal of Lipid Research. 45: 301-7. PMID 14657202 DOI: 10.1194/Jlr.M300377-Jlr200  1
2003 Graf GA, Yu L, Li WP, Gerard R, Tuma PL, Cohen JC, Hobbs HH. ABCG5 and ABCG8 Are Obligate Heterodimers for Protein Trafficking and Biliary Cholesterol Excretion Journal of Biological Chemistry. 278: 48275-48282. PMID 14504269 DOI: 10.1074/Jbc.M310223200  1
2003 Rader DJ, Cohen J, Hobbs HH. Monogenic hypercholesterolemia: New insights in pathogenesis and treatment Journal of Clinical Investigation. 111: 1795-1803. PMID 12813012 DOI: 10.1172/Jci18925  1
2003 Jones C, Hammer RE, Li WP, Cohen JC, Hobbs HH, Herz J. Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia. The Journal of Biological Chemistry. 278: 29024-30. PMID 12746448 DOI: 10.1074/Jbc.M304855200  1
2003 Cohen JC, Kimmel M, Polanski A, Hobbs HH. Molecular mechanisms of autosomal recessive hypercholesterolemia. Current Opinion in Lipidology. 14: 121-7. PMID 12642779 DOI: 10.1097/00041433-200304000-00002  1
2003 Yu L, York J, von Bergmann K, Lutjohann D, Cohen JC, Hobbs HH. Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8. The Journal of Biological Chemistry. 278: 15565-70. PMID 12601003 DOI: 10.1074/Jbc.M301311200  1
2002 Hobbs HH, Graf GA, Yu L, Wilund KR, Cohen JC. Genetic defenses against hypercholesterolemia Cold Spring Harbor Symposia On Quantitative Biology. 67: 499-505. PMID 12858576 DOI: 10.1101/Sqb.2002.67.499  1
2002 Yu L, Hammer RE, Li-Hawkins J, Von Bergmann K, Lutjohann D, Cohen JC, Hobbs HH. Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. Proceedings of the National Academy of Sciences of the United States of America. 99: 16237-42. PMID 12444248 DOI: 10.1073/Pnas.252582399  1
2002 Wilund KR, Yi M, Campagna F, Arca M, Zuliani G, Fellin R, Ho YK, Garcia JV, Hobbs HH, Cohen JC. Molecular mechanisms of autosomal recessive hypercholesterolemia. Human Molecular Genetics. 11: 3019-30. PMID 12417523 DOI: 10.1093/Hmg/11.24.3019  1
2002 He G, Gupta S, Yi M, Michaely P, Hobbs HH, Cohen JC. ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2. The Journal of Biological Chemistry. 277: 44044-9. PMID 12221107 DOI: 10.1074/jbc.M208539200  1
2002 Yu L, Li-Hawkins J, Hammer RE, Berge KE, Horton JD, Cohen JC, Hobbs HH. Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. The Journal of Clinical Investigation. 110: 671-80. PMID 12208868 DOI: 10.1172/Jci16001  1
2002 Graf GA, Li WP, Gerard RD, Gelissen I, White A, Cohen JC, Hobbs HH. Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface Journal of Clinical Investigation. 110: 659-669. PMID 12208867 DOI: 10.1172/Jci16000  1
2001 Hubacek JA, Berge KE, Cohen JC, Hobbs HH. Mutations in ATP-cassette binding proteins G5 (ABCG5) and G8 (ABCG8) causing sitosterolemia Human Mutation. 18: 359-360. PMID 11668628 DOI: 10.1002/HUMU.1206  1
2001 Yuhanna IS, Zhu Y, Cox BE, Hahner LD, Osborne-Lawrence S, Lu P, Marcel YL, Anderson RGW, Mendelsohn ME, Hobbs HH, Shaul PW. High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase Nature Medicine. 7: 853-857. PMID 11433352 DOI: 10.1038/89986  1
2001 Garcia CK, Mues G, Liao Y, Hyatt T, Patil N, Cohen JC, Hobbs HH. Sequence diversity in genes of lipid metabolism Genome Research. 11: 1043-1052. PMID 11381031 DOI: 10.1101/gr.172301  1
2000 Berge KE, Tian H, Graf GA, Yu L, Grishin NV, Schultz J, Kwiterovich P, Shan B, Barnes R, Hobbs HH. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters Science. 290: 1771-1775. PMID 11099417 DOI: 10.1126/Science.290.5497.1771  1
1999 Stangl H, Hyatt M, Hobbs HH. Transport of lipids from high and low density lipoproteins via scavenger receptor-BI. The Journal of Biological Chemistry. 274: 32692-8. PMID 10551825 DOI: 10.1074/jbc.274.46.32692  1
1999 Hobbs HH, Rader DJ. ABC1: Connecting yellow tonsils, neuropathy, and very low HDL Journal of Clinical Investigation. 104: 1015-1017. PMID 10525038 DOI: 10.1172/Jci8509  1
1999 Cao G, Zhao L, Stangl H, Hasegawa T, Richardson JA, Parker KL, Hobbs HH. Developmental and hormonal regulation of murine scavenger receptor, class B, type 1. Molecular Endocrinology (Baltimore, Md.). 13: 1460-73. PMID 10478838 DOI: 10.1210/mend.13.9.0346  1
1999 Hobbs HH, White AL. Lipoprotein(a): intrigues and insights. Current Opinion in Lipidology. 10: 225-36. PMID 10431659 DOI: 10.1097/00041433-199906000-00005  1
1998 Stangl H, Cao G, Wyne KL, Hobbs HH. Scavenger receptor, class B, type I-dependent stimulation of cholesterol esterification by high density lipoproteins, low density lipoproteins, and nonlipoprotein cholesterol. The Journal of Biological Chemistry. 273: 31002-8. PMID 9812997 DOI: 10.1074/jbc.273.47.31002  1
1998 Sanan DA, Newland DL, Tao R, Marcovina S, Wang J, Mooser V, Hammer RE, Hobbs HH. Low density lipoprotein receptor-negative mice expressing human apolipoprotein B-100 develop complex atherosclerotic lesions on a chow diet: no accentuation by apolipoprotein(a). Proceedings of the National Academy of Sciences of the United States of America. 95: 4544-9. PMID 9539774 DOI: 10.1073/PNAS.95.8.4544  1
1997 Cao G, Garcia CK, Wyne KL, Schultz RA, Parker KL, Hobbs HH. Structure and localization of the human gene encoding SR-BI/CLA-1. Evidence for transcriptional control by steroidogenic factor 1. The Journal of Biological Chemistry. 272: 33068-76. PMID 9407090 DOI: 10.1074/jbc.272.52.33068  1
1997 Mooser V, Scheer D, Marcovina SM, Wang J, Guerra R, Cohen J, Hobbs HH. The apo(a) gene is the major determinant of variation in plasma Lp(a) levels in African Americans American Journal of Human Genetics. 61: 402-417. PMID 9311746 DOI: 10.1086/514851  1
1996 Mooser V, Marcovina SM, White AL, Hobbs HH. Kringle-containing fragments of apolipoprotein(a) circulate in human plasma and are excreted into the urine. The Journal of Clinical Investigation. 98: 2414-24. PMID 8941661 DOI: 10.1172/JCI119055  1
1996 Landschulz KT, Pathak RK, Rigotti A, Krieger M, Hobbs HH. Regulation of scavenger receptor, class B, type I, a high density lipoprotein receptor, in liver and steroidogenic tissues of the rat. The Journal of Clinical Investigation. 98: 984-95. PMID 8770871 DOI: 10.1172/JCI118883  1
1996 Wyne KL, Pathak RK, Seabra MC, Hobbs HH. Expression of the VLDL receptor in endothelial cells Arteriosclerosis, Thrombosis, and Vascular Biology. 16: 407-415. PMID 8630667 DOI: 10.1161/01.ATV.16.3.407  1
1996 Mooser V, Seabra MC, Abedin M, Landschulz KT, Marcovina S, Hobbs HH. Apolipoprotein(a) kringle 4-containing fragments in human urine. Relationship to plasma levels of lipoprotein(a). The Journal of Clinical Investigation. 97: 858-64. PMID 8609245 DOI: 10.1172/JCI118487  1
1995 Moliterno DJ, Jokinen EV, Miserez AR, Lange RA, Willard JE, Boerwinkle E, Hillis LD, Hobbs HH. No association between plasma lipoprotein(a) concentrations and the presence or absence of coronary atherosclerosis in African-Americans. Arteriosclerosis, Thrombosis, and Vascular Biology. 15: 850-5. PMID 7600116 DOI: 10.1161/01.ATV.15.7.850  1
1994 Gaw A, Boerwinkle E, Cohen JC, Hobbs HH. Comparative analysis of the apo(a) gene, apo(a) glycoprotein, and plasma concentrations of Lp(a) in three ethnic groups: Evidence for no common "null" allele at the apo(a) locus Journal of Clinical Investigation. 93: 2526-2534. PMID 8200989 DOI: 10.1172/Jci117263  1
1993 Cohen JC, Chiesa G, Hobbs HH. Sequence polymorphisms in the apolipoprotein(a) gene: Evidence for dissociation between apolipoprotein(a) size and plasma lipoprotein(a) levels Journal of Clinical Investigation. 91: 1630-1636. PMID 8473506 DOI: 10.1172/JCI116370  1
1993 Lackner C, Cohen JC, Hobbs HH. Molecular definition of the extreme size polymorphism in apolipoprotein(a) Human Molecular Genetics. 2: 933-940. PMID 8395942 DOI: 10.1093/hmg/2.7.933  1
1993 Moliterno DJ, Lange RA, Meidell RS, Willard JE, Leffert CC, Gerard RD, Boerwinkle E, Hobbs HH, Hillis LD. Relation of plasma lipoprotein(a) to infarct artery patency in survivors of myocardial infarction. Circulation. 88: 935-40. PMID 8353920 DOI: 10.1161/01.CIR.88.3.935  1
1993 Linton MF, Farese RV, Chiesa G, Grass DS, Chin P, Hammer RE, Hobbs HH, Young SG. Transgenic mice expressing high plasma concentrations of human apolipoprotein B100 and lipoprotein (a) Journal of Clinical Investigation. 92: 3029-3037. PMID 8254057 DOI: 10.1172/JCI116927  1
1990 Leitersdorf E, Tobin EJ, Davignon J, Hobbs HH. Common low-density lipoprotein receptor mutations in the French Canadian population Journal of Clinical Investigation. 85: 1014-1023. PMID 2318961 DOI: 10.1172/JCI114531  1
1989 Leitersdorf E, Van Der Westhuyzen DR, Coetzee GA, Hobbs HH. Two common low density lipoprotein receptor gene mutations cause familial hypercholesterolemia in Afrikaners Journal of Clinical Investigation. 84: 954-961. PMID 2569482  1
1988 Leitersdorf E, Hobbs HH, Fourie AM, Jacobs M, Van der Westhuyzen DR, Coetzee GA. Deletion in the first cysteine-rich repeat of low density lipoprotein receptor impairs its transport but not lipoprotein binding in fibroblasts from a subject with familial hypercholesterolemia Proceedings of the National Academy of Sciences of the United States of America. 85: 7912-7916. PMID 3263645  1
1986 Russell DW, Lehrman MA, Südhof TC, Yamamoto T, Davis CG, Hobbs HH, Brown MS, Goldstein JL. The LDL receptor in familial hypercholesterolemia: use of human mutations to dissect a membrane protein. Cold Spring Harbor Symposia On Quantitative Biology. 51: 811-9. PMID 3472763 DOI: 10.1101/Sqb.1986.051.01.094  1
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