Joseph Larner - Publications

Affiliations: 
Pharmacology University of Virginia School of Medicine, Charlottesville, VA, United States 

140 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Lazarenko R, Geisler J, Bayliss D, Larner J, Li C. D-chiro-inositol glycan stimulates insulin secretion in pancreatic β cells Molecular and Cellular Endocrinology. 387: 1-7. PMID 24530497 DOI: 10.1016/J.Mce.2014.02.004  0.434
2014 Heimark D, McAllister J, Larner J. Decreased myo-inositol to chiro-inositol (M/C) ratios and increased M/C epimerase activity in PCOS theca cells demonstrate increased insulin sensitivity compared to controls. Endocrine Journal. 61: 111-7. PMID 24189751 DOI: 10.1507/Endocrj.Ej13-0423  0.486
2013 Larner J. Inositol, glycogen, insulin, and six nobelists. The Journal of Biological Chemistry. 288: 12313-24. PMID 23515311 DOI: 10.1074/Jbc.X113.471177  0.483
2013 Pitt J, Thorner M, Brautigan D, Larner J, Klein WL. Protection against the synaptic targeting and toxicity of Alzheimer's-associated Aβ oligomers by insulin mimetic chiro-inositols. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 199-207. PMID 23073831 DOI: 10.1096/Fj.12-211896  0.497
2010 Larner J, Brautigan DL, Thorner MO. D-chiro-inositol glycans in insulin signaling and insulin resistance. Molecular Medicine (Cambridge, Mass.). 16: 543-52. PMID 20811656 DOI: 10.2119/Molmed.2010.00107  0.55
2010 Hans SK, Camara F, Altiti A, Martín-Montalvo A, Brautigan DL, Heimark D, Larner J, Grindrod S, Brown ML, Mootoo DR. Synthesis of C-glycoside analogues of beta-galactosamine-(1-->4)-3-O-methyl-D-chiro-inositol and assay as activator of protein phosphatases PDHP and PP2Calpha. Bioorganic & Medicinal Chemistry. 18: 1103-10. PMID 20079654 DOI: 10.1016/J.Bmc.2009.12.056  0.442
2010 Gluck G, Anguelova T, Heimark D, Larner J. Synergistic Effects of d-Chiro-Inositol and Manganese on Blood Glucose and Body Weight of Streptozotocin-Induced Diabetic Rats Current Bioactive Compounds. 6: 90-96. DOI: 10.2174/157340710791184831  0.328
2009 Larner J, Allen G, Sleevi M, Price J, Rule G, Piccariello T, Abe S, Heimark D, Huang LC. Molecular mechanism of insulin resistance. Structure and formation of a novel galactosamine disaccharide – A putative insulin mediator Experimental and Clinical Endocrinology & Diabetes. 105: 10-11. DOI: 10.1055/S-0029-1211821  0.388
2006 Nascimento NR, Lessa LM, Kerntopf MR, Sousa CM, Alves RS, Queiroz MG, Price J, Heimark DB, Larner J, Du X, Brownlee M, Gow A, Davis C, Fonteles MC. Inositols prevent and reverse endothelial dysfunction in diabetic rat and rabbit vasculature metabolically and by scavenging superoxide. Proceedings of the National Academy of Sciences of the United States of America. 103: 218-23. PMID 16373499 DOI: 10.1073/Pnas.0509779103  0.344
2006 Larner J. Insulin and the Stimulation of Glycogen Synthesis. The Road from Glycogen Structure to Glycogen Synthase to Cyclic Amp‐Dependent Protein Kinase to Insulin Mediators Advances in Enzymology and Related Areas of Molecular Biology. 63: 173-231. PMID 2154910 DOI: 10.1002/9780470123096.Ch3  0.517
2005 Brautigan DL, Brown M, Grindrod S, Chinigo G, Kruszewski A, Lukasik SM, Bushweller JH, Horal M, Keller S, Tamura S, Heimark DB, Price J, Larner AN, Larner J. Allosteric activation of protein phosphatase 2C by D-chiro-inositol-galactosamine, a putative mediator mimetic of insulin action. Biochemistry. 44: 11067-73. PMID 16101290 DOI: 10.1021/Bi0508845  0.546
2005 Brautigan DL, Brown MF, Grindrod S, Chinigo G, Kruszewski A, Lukasik SM, Bushweller JH, Horal M, Keller S, Tamura S, Heimark DB, Price J, Larner AN, Larner J. Erratum: Allosteric activation of protein phosphatase 2C by D-chiro-inositol-galactosamine, a putative mediator mimetic of insulin action (Biochemistry (August 23, 2005) 44, 33 (11067-11073)) Biochemistry. 44. DOI: 10.1021/Bi0580308  0.484
2003 Larner J, Price JD, Heimark D, Smith L, Rule G, Piccariello T, Fonteles MC, Pontes C, Vale D, Huang L. Isolation, structure, synthesis, and bioactivity of a novel putative insulin mediator. A galactosamine chiro-inositol pseudo-disaccharide Mn2+ chelate with insulin-like activity. Journal of Medicinal Chemistry. 46: 3283-91. PMID 12852758 DOI: 10.1021/Jm030071J  0.507
2002 Shashkin PN, Huang LC, Larner J, Vandenhoff GE, Katz A. Fasting decreases the content of D-chiroinositol in human skeletal muscle. International Journal of Experimental Diabetes Research. 3: 163-9. PMID 12458657 DOI: 10.1080/15604280214280  0.491
2002 Sleight S, Wilson BA, Heimark DB, Larner J. G(q/11) is involved in insulin-stimulated inositol phosphoglycan putative mediator generation in rat liver membranes: co-localization of G(q/11) with the insulin receptor in membrane vesicles. Biochemical and Biophysical Research Communications. 295: 561-9. PMID 12150987 DOI: 10.1016/S0006-291X(02)00701-5  0.508
2002 Sun TH, Heimark DB, Nguygen T, Nadler JL, Larner J. Both myo-inositol to chiro-inositol epimerase activities and chiro-inositol to myo-inositol ratios are decreased in tissues of GK type 2 diabetic rats compared to Wistar controls. Biochemical and Biophysical Research Communications. 293: 1092-8. PMID 12051772 DOI: 10.1016/S0006-291X(02)00313-3  0.448
2002 Larner J. D-chiro-inositol--its functional role in insulin action and its deficit in insulin resistance. International Journal of Experimental Diabetes Research. 3: 47-60. PMID 11900279 DOI: 10.1080/15604280212528  0.53
2001 Larner J. D-chiro-inositol in insulin action and insulin resistance-old-fashioned biochemistry still at work. Iubmb Life. 51: 139-148. PMID 11547915 DOI: 10.1080/152165401753544205  0.491
1999 Huang LC, Heimark D, Linko J, Nolan R, Larner J. A model phosphatase 2C --> phosphatase 1 activation cascade via dual control of inhibitor-1 (INH-1) and DARPP-32 dephosphorylation by two inositol glycan putative insulin mediators from beef liver. Biochemical and Biophysical Research Communications. 255: 150-6. PMID 10082671 DOI: 10.1006/Bbrc.1999.0111  0.508
1998 LARNER J, VILLAR-PALASI C, RICHMAN DJ. Insulin-stimulated glycogen formation in rat diaphragm. Levels of tissue intermediates in short-time experiments. Archives of Biochemistry and Biophysics. 86: 56-60. PMID 14414225 DOI: 10.1016/0003-9861(60)90367-2  0.34
1998 LARNER J, VILLAR PALASI CV, RICHMAN DJ. Insulin-stimulated glycongen formation in rat diaphragm. Annals of the New York Academy of Sciences. 82: 345-53. PMID 14414224 DOI: 10.1111/j.1749-6632.1959.tb44915.x  0.372
1998 VILLAR-PALASI C, LARNER J. Insulin-mediated effect on the activity of UDPG-glycogen transglucosylase of muscle. Biochimica Et Biophysica Acta. 39: 171-3. PMID 13842294 DOI: 10.1016/0006-3002(60)90142-6  0.405
1998 VILLAR-PALASI C, LARNER J. Insulin treatment and increased UDPG-glycogen transglucosylase activity in muscle. Archives of Biochemistry and Biophysics. 94: 436-42. PMID 13781408 DOI: 10.1016/0003-9861(61)90071-6  0.378
1998 Ortmeyer HK, Huang L, Larner J, Hansen BC. Insulin unexpectedly increases the glucose 6-phosphate Ka of skeletal muscle glycogen synthase in calorie-restricted monkeys. Journal of Basic and Clinical Physiology and Pharmacology. 9: 309-23. PMID 10212841 DOI: 10.1515/Jbcpp.1998.9.2-4.309  0.483
1998 Larner J, Allan G, Kessler C, Reamer P, Gunn R, Huang LC. Phosphoinositol glycan derived mediators and insulin resistance. Prospects for diagnosis and therapy. Journal of Basic and Clinical Physiology and Pharmacology. 9: 127-37. PMID 10212830 DOI: 10.1515/Jbcpp.1998.9.2-4.127  0.53
1997 Katz A, Hultman E, Huang L, Villar-Palasi C, Larner J. No change in insulin mediators in human skeletal muscle during isometric contraction or recovery. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme. 28: 545-8. PMID 8934213 DOI: 10.1055/S-2007-979849  0.375
1997 Paule CR, Larner J. Characterization of a nucleotide stimulated aspartic proteinase in rat liver plasma membranes. Journal of Basic and Clinical Physiology and Pharmacology. 7: 121-36. PMID 8876431 DOI: 10.1515/JBCPP.1996.7.2.121  0.349
1996 Fonteles MC, Huang LC, Larner J. Infusion of pH 2.0 D-chiro-inositol glycan insulin putative mediator normalizes plasma glucose in streptozotocin diabetic rats at a dose equivalent to insulin without inducing hypoglycaemia. Diabetologia. 39: 731-4. PMID 8781770 DOI: 10.1007/BF00418546  0.416
1996 Galasko GTF, Abe S, Lilley K, Zhang C, Larner J. Circulating factors and insulin resistance. II. The action of the novel myo-inositol cyclic 1,2-inositol phosphate phosphoglycan insulin antagonist from human plasma in regulating pyruvate dehydrogenase phosphatase. The Journal of Clinical Endocrinology and Metabolism. 81: 1051-1057. PMID 8772575 DOI: 10.1210/Jcem.81.3.8772575  0.544
1996 Larner J, Craig JW. Urinary myo-inositol-to-chiro-inositol ratios and insulin resistance. Diabetes Care. 19: 76-8. PMID 8720541 DOI: 10.2337/Diacare.19.1.76  0.449
1995 Ortmeyer HK, Larner J, Hansen BC. Effects of D-chiroinositol added to a meal on plasma glucose and insulin in hyperinsulinemic rhesus monkeys. Obesity Research. 3: 605S-608S. PMID 8697063 DOI: 10.1002/J.1550-8528.1995.Tb00232.X  0.447
1995 Galasko GTF, Bao Y, Broomfield SJ, Hooper NM, Turner AJ, Larner J. Circulating factors and insulin resistance. I. A novel myoinositol 1,2-cyclic phosphate phosphoglycan insulin antagonist from human plasma is elevated in noninsulin-dependent diabetes mellitus. The Journal of Clinical Endocrinology and Metabolism. 80: 2419-2429. PMID 7629237 DOI: 10.1210/Jcem.80.8.7629237  0.488
1994 Suzuki S, Kawasaki H, Satoh Y, Ohtomo M, Hirai M, Hirai A, Hirai S, Onoda M, Matsumoto M, Hinokio Y, Akai H, Craig J, Larner J, Toyota T. Urinary chiro-Inositol Excretion is an Index Marker of Insulin Sensitivity in Japanese Type II Diabetes Diabetes Care. 17: 1465-1468. PMID 7882818 DOI: 10.2337/Diacare.17.12.1465  0.395
1993 Romero G, Larner J. Insulin mediators and the mechanism of insulin action Advances in Pharmacology (San Diego, Calif.). 24: 21-50. PMID 8504064 DOI: 10.1016/S1054-3589(08)60932-1  0.552
1993 Huang LC, Fonteles MC, Houston DB, Zhang C, Larner J. Chiroinositol deficiency and insulin resistance. III. Acute glycogenic and hypoglycemic effects of two inositol phosphoglycan insulin mediators in normal and streptozotocin-diabetic rats in vivo. Endocrinology. 132: 652-7. PMID 8425485 DOI: 10.1210/Endo.132.2.8425485  0.53
1993 Ortmeyer HK, Huang LC, Zhang L, Hansen BC, Larner J. Chiroinositol deficiency and insulin resistance. II. Acute effects of D-chiroinositol administration in streptozotocin-diabetic rats, normal rats given a glucose load, and spontaneously insulin-resistant rhesus monkeys. Endocrinology. 132: 646-51. PMID 8425484 DOI: 10.1210/endo.132.2.8425484  0.361
1993 Ortmeyer HK, Bodkin NL, Lilley K, Larner J, Hansen BC. Chiroinositol deficiency and insulin resistance. I. Urinary excretion rate of chiroinositol is directly associated with insulin resistance in spontaneously diabetic rhesus monkeys. Endocrinology. 132: 640-5. PMID 8425483 DOI: 10.1210/ENDO.132.2.8425483  0.368
1993 Asplin I, Galasko G, Larner J. chiro-Inositol deficiency and insulin resistance: A comparison of the chiro-inositol- and the myo-inositol-containing insulin mediators isolated from urine, hemodialysate, and muscle of control and type II diabetic subjects Proceedings of the National Academy of Sciences of the United States of America. 90: 5924-5928. PMID 8392181 DOI: 10.1073/Pnas.90.13.5924  0.362
1993 Pak Y, Paule CR, Bao YD, Huang LC, Larner J. Insulin stimulates the biosynthesis of chiro-inositol-containing phospholipids in a rat fibroblast line expressing the human insulin receptor. Proceedings of the National Academy of Sciences of the United States of America. 90: 7759-63. PMID 8356081 DOI: 10.1073/PNAS.90.16.7759  0.422
1993 Nagasaka Y, Okubo M, Larner J. Mechanisms of aluminium fluoride- and insulin-stimulated p33 mRNA accumulation in rat hepatoma cells: Involvement of a G protein and kinase action and demonstration of effects on mRNA turnover Cellular Signalling. 5: 633-641. PMID 8312137 DOI: 10.1016/0898-6568(93)90058-T  0.518
1992 Pak Y, Larner J. Identification and characterization of chiroinositol-containing phospholipids from bovine liver Biochemical and Biophysical Research Communications. 184: 1042-1047. PMID 1575723 DOI: 10.1016/0006-291X(92)90696-I  0.318
1992 Kilgour E, Larner J, Romero G. The generation of inositolglycan mediators from rat liver plasma membranes: The role of guanine nucleotide binding proteins Biochemical and Biophysical Research Communications. 186: 1151-1157. PMID 1497649 DOI: 10.1016/0006-291X(92)90867-K  0.476
1992 Lilley K, Zhang C, Villar-Palasi C, Larner J, Huang L. Insulin mediator stimulation of pyruvate dehydrogenase phosphatases. Archives of Biochemistry and Biophysics. 296: 170-174. PMID 1318688 DOI: 10.1016/0003-9861(92)90559-F  0.494
1991 Nestler JE, Romero G, Huang LC, Zhang CG, Larner J. Insulin mediators are the signal transduction system responsible for insulin's actions on human placental steroidogenesis. Endocrinology. 129: 2951-6. PMID 1954880 DOI: 10.1210/Endo-129-6-2951  0.461
1991 Okubo M, Villar-Palasi C, Nagasaka Y, Larner J, Larner AC, Bai G, Lee EYC. Long-term effects of insulin on the enzyme activity and messenger RNA of glycogen synthase in rat hepatoma H4 cells: an effect of insulin on glycogen synthase mRNA stability. Archives of Biochemistry and Biophysics. 288: 126-130. PMID 1910304 DOI: 10.1016/0003-9861(91)90173-G  0.534
1991 Larner J. From enzyme to transport and back to enzyme--insulin action over forty years. Endocrinology. 129: 8-10. PMID 1647313 DOI: 10.1210/Endo-129-1-8  0.534
1990 Kennington AS, Hill CR, Craig J, Bogardus C, Raz I, Ortmeyer HK, Hansen BC, Romero G, Larner J. Low urinary chiro-inositol excretion in non-insulin-dependent diabetes mellitus. The New England Journal of Medicine. 323: 373-378. PMID 2370888 DOI: 10.1056/Nejm199008093230603  0.379
1990 Luttrell L, Kilgour E, Larner J, Romero G. A pertussis toxin-sensitive G-protein mediates some aspects of insulin action in BC3H-1 murine myocytes. Journal of Biological Chemistry. 265: 16873-16879. DOI: 10.1016/s0021-9258(17)44843-5  0.357
1989 Larner J, Huang LC, Suzuki S, Tang G, Zhang C, Schwartz CF, Romero G, Luttrell L, Kennington AS. Insulin mediators and the control of pyruvate dehydrogenase complex. Annals of the New York Academy of Sciences. 573: 297-305. PMID 2517463 DOI: 10.1111/J.1749-6632.1989.Tb15006.X  0.475
1988 Sato T, Larner J, Larner AC. Selective transcription of an insulin-regulated gene in nuclear extracts of rat hepatoma cells. Biochemical and Biophysical Research Communications. 153: 116-127. PMID 3288202 DOI: 10.1016/S0006-291X(88)81197-5  0.433
1988 Romero G, Luttrell L, Rogol A, Zeller K, Hewlett E, Larner J. Phosphatidylinositol-glycan anchors of membrane proteins: potential precursors of insulin mediators. Science (New York, N.Y.). 240: 509-11. PMID 3282305 DOI: 10.1126/Science.3282305  0.512
1988 Sato T, Ye T, Larner A, Larner J. Contrasting interactions between phorbol ester and insulin on the regulation of glycogen synthase activity and p33 mRNA accumulation in rat hepatoma cells Archives of Biochemistry and Biophysics. 260: 377-387. PMID 3124751 DOI: 10.1016/0003-9861(88)90461-4  0.543
1988 Larner J, Huang LC, Tang G, Suzuki S, Schwartz CF, Romero G, Roulidis Z, Zeller K, Shen TY, Oswald AS. Insulin mediators: structure and formation. Cold Spring Harbor Symposia On Quantitative Biology. 53: 965-71. PMID 3076102 DOI: 10.1101/Sqb.1988.053.01.111  0.475
1988 Sato T, Palasi CV, Huang L, Tang G, Larner AC, Larner J. Insulin and a putative insulin metabolic mediator fraction from liver and muscle stimulate p33 Messenger ribonucleic acid accumulation by apparently different mechanisms Endocrinology. 123: 1559-1564. PMID 3042371 DOI: 10.1210/Endo-123-3-1559  0.512
1988 Larner J. Insulin-Signaling Mechanisms: Lessons From the Old Testament of Glycogen Metabolism and the New Testament of Molecular Biology Diabetes. 37: 262-275. PMID 2836249 DOI: 10.2337/Diab.37.3.262  0.441
1988 Larner J, Huang LC, Schwartz CF, Oswald AS, Shen TY, Kinter M, Tang GZ, Zeller K. Rat liver insulin mediator which stimulates pyruvate dehydrogenase phosphate contains galactosamine and D-chiroinositol. Biochemical and Biophysical Research Communications. 151: 1416-26. PMID 2833261 DOI: 10.1016/S0006-291X(88)80520-5  0.473
1987 Messina JL, Hamlin J, Larner J. Insulin-mimetic actions of wheat germ agglutinin and concanavalin A on specific mRNA levels Archives of Biochemistry and Biophysics. 254: 110-115. PMID 3555340 DOI: 10.1016/0003-9861(87)90086-5  0.483
1987 Messina JL, Hamlin J, Larner J. Positive interaction between insulin and phorbol esters on the regulation of a specific messenger ribonucleic acid in rat hepatoma cells Endocrinology. 121: 1227-1232. PMID 3308433 DOI: 10.1210/Endo-121-4-1227  0.462
1987 Cheng K, Larner J. Stable" effects of insulin and isoproterenol on adipocyte pyruvate dehydrogenase. Archives of Biochemistry and Biophysics. 256: 699-702. PMID 3113337 DOI: 10.1016/0003-9861(87)90627-8  0.534
1987 Goheer MA, Larner J, Curnow RT. Long term regulation of glycogen metabolizing enzymes by insulin in H4 hepatoma cells. Molecular and Cellular Biochemistry. 75: 137. PMID 3041200 DOI: 10.1007/Bf00229902  0.506
1987 Malchoff CD, Huang L, Gillespie N, Palasi CV, Schwartz CF, Cheng K, Hewlett EL, Larner J. A putative mediator of insulin action which inhibits adenylate cyclase and adenosine 3',5'-monophosphate-dependent protein kinase: Partial purification from rat liver: Site and kinetic mechanism of action Endocrinology. 120: 1327-1337. PMID 3030696 DOI: 10.1210/Endo-120-4-1327  0.558
1987 Suzuki S, Toyota T, Tamura S, Kikuchi K, Tsuiki S, Huang L, Villar-Palasi C, Larner J, Goto Y. ATP-Mn2+ stimulates the generation of a putative mediator of insulin action. Journal of Biological Chemistry. 262: 3199-3204. DOI: 10.1016/s0021-9258(18)61491-7  0.389
1987 Leef JW, Larner J. Insulin-mimetic effect of trypsin on the insulin receptor tyrosine kinase in intact adipocytes. Journal of Biological Chemistry. 262: 14837-14842. DOI: 10.1016/s0021-9258(18)47871-4  0.436
1986 Malchoff CD, Messina JL, Gordon V, Tamura S, Larner J. Inhibition of insulin receptor phosphorylation by indomethacin. Molecular and Cellular Biochemistry. 69: 83-91. PMID 3935910 DOI: 10.1007/Bf00225930  0.513
1986 Larner J. 35 Years of research in glycogen metabolism. Journal of the Japanese Society of Starch Science. 33: 71-79. DOI: 10.5458/Jag1972.33.71  0.447
1985 Craig JW, Larner J, Locker EF, Elders MJ. Mechanisms of insulin resistance in cultured fibroblasts from a patient with leprechaunism: resistance to proteolytic activation of glycogen synthase by trypsin. Molecular and Cellular Biochemistry. 66: 117-25. PMID 3920504 DOI: 10.1007/BF00220779  0.444
1985 Altan N, Altan VM, Mikolay L, Larner J, Schwartz CF. Insulin-like and insulin-enhancing effects of the sulfonylurea glyburide on rat adipose glycogen synthase. Diabetes. 34: 281-6. PMID 3918901 DOI: 10.2337/diab.34.3.281  0.443
1985 Messina JL, Hamlin J, Azizkahn J, Larner J. The effects of insulin and concanavalin A on the accumulation of a specific mRNA in rat hepatoma cells Biochemical and Biophysical Research Communications. 133: 1168-1174. PMID 3910044 DOI: 10.1016/0006-291X(85)91259-8  0.47
1985 Dubler RE, Whipple JH, Larner J. Characterization of skeletal muscle insulin receptor Archives of Biochemistry and Biophysics. 236: 119-129. PMID 3881080 DOI: 10.1016/0003-9861(85)90611-3  0.51
1985 Cheng K, Larner J. Intracellular mediators of insulin action. Annual Review of Physiology. 47: 405-24. PMID 2986536 DOI: 10.1146/annurev.ph.47.030185.002201  0.432
1985 Cheng K, Larner J. Unidirectional actions of insulin and Ca2+-dependent hormones on adipocyte pyruvate dehydrogenase. Journal of Biological Chemistry. 260: 5279-5285. DOI: 10.1016/s0021-9258(18)89018-4  0.346
1984 Oron Y, Emerson JF, Garrison JC, Larner J. Calcium control of glycogen synthase activities in mouse diaphragms, rat adipocytes and rat hepatocytes Cell Calcium. 5: 143-158. PMID 6428746 DOI: 10.1016/0143-4160(84)90013-7  0.36
1984 Thompson MP, Larner J, Kilpatrick DL. Purification and partial characterization of a putative mediator of insulin action on cyclic AMP-dependent protein kinase Molecular and Cellular Biochemistry. 62: 67-75. PMID 6377044 DOI: 10.1007/Bf00230079  0.456
1984 Veldhuis TD, Tamura S, Kolp L, Furlanetto RW, Larner J. Mechanisms subserving insulin action in the gonad: Evidence that insulin induces specific phosphorylation of its immunoprecipitable receptor on ovarian cells Biochemical and Biophysical Research Communications. 120: 144-149. PMID 6370258 DOI: 10.1016/0006-291X(84)91425-6  0.522
1984 Tamura S, Schwartz CFW, Whipple JH, Dubler RE, Fujita-Yamaguchi Y, Larner J. Selective inhibition of the insulin-stimulated phosphorylation of the 95,000 dalton subunit of the insulin receptor by TAME or BAEE. Biochemical and Biophysical Research Communications. 119: 465-472. PMID 6370244 DOI: 10.1016/S0006-291X(84)80272-7  0.475
1984 Craig JW, Larner J, Locker EF, Widom B, Elders MJ. Mechanisms of insulin resistance in cultured fibroblasts from a patient with leprechaunism: impaired post-binding actions of insulin and multiplication-stimulating activity. Metabolism: Clinical and Experimental. 33: 1084-96. PMID 6094962 DOI: 10.1016/0026-0495(84)90092-1  0.527
1984 Larner J. Membrane signaling mechanisms in insulin action Trends in Pharmacological Sciences. 5: 67-70. DOI: 10.1016/0165-6147(84)90370-5  0.434
1983 Cheng K, Creacy S, Larner J. 'Insulin-like' effects of lithium ion on isolated rat adipocytes. I. Stimulation of glycogenesis beyond glucose transport. Molecular and Cellular Biochemistry. 56: 177-182. PMID 6646115 DOI: 10.1007/Bf00227218  0.465
1983 Cheng K, Creacy S, Larner J. Insulin-likë effects of lithium ion on isolated rat adipocytes. II: Specific activation of glycogen synthase Molecular and Cellular Biochemistry. 56: 183-189. PMID 6417471 DOI: 10.1007/Bf00227219  0.436
1983 Hidaka H, Ishibashi F, Larner J, Howard BV. Effect of temperature on insulin binding and action in cultured human fibroblasts. Life Sciences. 33: 1157-1165. PMID 6412011 DOI: 10.1016/0024-3205(83)90020-6  0.476
1983 Tamura S, Brown TA, Dubler RE, Larner J. Insulin-like effect of vanadate on adipocyte glycogen synthase and on phosphorylation of 95,000 dalton subunit of insulin receptor. Biochemical and Biophysical Research Communications. 113: 80-86. PMID 6407485 DOI: 10.1016/0006-291X(83)90434-5  0.55
1983 Larner J. Mediators of postreceptor action of insulin. The American Journal of Medicine. 74: 38-51. PMID 6297300 DOI: 10.1016/0002-9343(83)90653-8  0.508
1983 Cheng K, Thompson M, Craig J, Schwartz C, Locher E, Larner J. PUTATIVE MEDIATORS OF METABOLIC ACTIONS OF INSULIN. Acta Endocrinologica. 104: S46-S52. DOI: 10.1530/Acta.0.103S046  0.479
1983 Tamura S, Dubler RE, Larner J. Stimulation of maximal intracellular insulin action on glycogen synthase by preincubation of adipocytes with adenosine 5'-triphosphate. Journal of Biological Chemistry. 258: 719-724. DOI: 10.1016/s0021-9258(18)33107-7  0.435
1983 Tamura S, Fujita-Yamaguchi Y, Larner J. Insulin-like effect of trypsin on the phosphorylation of rat adipocyte insulin receptor. Journal of Biological Chemistry. 258: 14749-14752. DOI: 10.1016/s0021-9258(17)43720-3  0.441
1982 Larner J, Cheng K, Schwartz C, Kikuchi K, Tamura S, Creacy S, Dubler R, Galasko G, Pullin C, Katz M. Insulin mediators and their control of metabolism through protein phosphorylation. Recent Progress in Hormone Research. 38: 511-556. PMID 6812180 DOI: 10.1016/B978-0-12-571138-8.50017-2  0.464
1981 Hidaka H, Howard BV, Ishibashi F, Kosmakos FC, Craig JW, Bennett PH, Larner J. Effect of pH and 3-hydroxybutyrate on insulin binding and action in cultured human fibroblasts. Diabetes. 30: 402-6. PMID 7014308 DOI: 10.2337/Diab.30.5.402  0.483
1981 Larner J, Cheng K, Schwartz C, Dubler R, Creacy S, Kikuchi K, Tamura S, Galasko G, Pullin C, Katz M. Chemical mechanism of insulin action via proteolytic formation of mediator peptides Molecular and Cellular Biochemistry. 40: 155-161. PMID 6798421 DOI: 10.1007/Bf00224609  0.435
1981 Kikuchi K, Schwartz C, Creacy S, Larner J. Independent control of selected insulin-sensitive cell membrane and intracellular functions-the linkage of cell membrane and intracellular events controlled by insulin. III. The influence of trypsin on cell membrane hexose transport and on glycogen synthase and mitochondrial pyruvate dehydrogenase activation. Molecular and Cellular Biochemistry. 37: 125-130. PMID 6792503 DOI: 10.1007/Bf02354936  0.525
1981 Kikuchi K, Larner J. Independent control of selected insulin-sensitive cell membrane and intracellular functions—the linkage of cell membrane and intracellular events controlled by insulin Molecular and Cellular Biochemistry. 37: 109-115. PMID 6792501 DOI: 10.1007/Bf02354934  0.469
1981 Kikuchi K, Larner J, Freer R, Day A. Effect of insulin fragments on biological activity of insulin and desoctapeptide insulin. II. Enhanced binding and mechanism studies. Journal of Biological Chemistry. 256: 9445-9449. DOI: 10.1016/s0021-9258(19)68782-x  0.426
1980 Bier DM, Schedewie H, Larner J, Olefsky J, Rubenstein A, Fiser RH, Craig JW, Elders MJ. Glucose kinetics in leprechaunism: accelerated fasting due to insulin resistance. The Journal of Clinical Endocrinology and Metabolism. 51: 988-94. PMID 6999010 DOI: 10.1210/Jcem-51-5-988  0.425
1980 Hidaka H, Howard BV, Kosmakos FC, Fields RM, Craig JW, Bennett PH, Larner J. Insulin stimulation of glycogen synthase in cultured human diploid fibroblasts. Diabetes. 29: 806-10. PMID 6777220 DOI: 10.2337/Diacare.20.10.806  0.537
1980 Kikuchi K, Larner J, Freer R, Day AR. Enhanced specific insulin binding and insulin action with C-terminal B-chain pentapeptide derived from insulin. Febs Letters. 119: 161-4. PMID 6775976 DOI: 10.1016/0014-5793(80)81021-0  0.499
1980 Craig JW, Huang LS, Larner J. Insulin stimulation of glycogen synthase activity in cultured human fibroblasts from diabetic and control subjects. Diabetologia. 18: 109-13. PMID 6767640 DOI: 10.1007/BF00290485  0.316
1980 Oron Y, Galasko G, Larner J. Insulin action in intact mouse diaphragm. II. Inhibition of endogenous protein phosphorylation. Molecular and Cellular Biochemistry. 32: 161-167. PMID 6258052 DOI: 10.1007/Bf00227443  0.521
1980 Cheng K, Galasko G, Huang L, Kellogg J, Larner J. Studies on the Insulin Mediator: II. Separation of Two Antagonistic Biologically Active Materials from Fraction II Diabetes. 29: 659-661. PMID 6254825 DOI: 10.2337/Diab.29.8.659  0.504
1980 Walkenbach RJ, Hazen R, Larner J. Hormonal regulation of glycogen synthase: Insulin decreases protein kinase sensitivity to cyclic AMP Biochimica Et Biophysica Acta. 629: 421-430. PMID 6251903 DOI: 10.1016/0304-4165(80)90148-8  0.553
1980 Guinovart JJ, Larner J. Epinephrinee effects on cyclic amp-dependent protein kinases from rat diaphragms Biochimica Et Biophysica Acta. 631: 253-263. PMID 6250636 DOI: 10.1016/0304-4165(80)90300-1  0.348
1980 Kikuchi K, Larner J, Freer R, Day A, Morris H, Dell A. Studies on the biological activity of degraded insulins and insulin fragments. Journal of Biological Chemistry. 255: 9281-9288. DOI: 10.1016/s0021-9258(19)70559-6  0.435
1980 Oron Y, Larner J. Insulin action in intact mouse diaphragm. I. Activation of glycogen synthase through stimulation of sugar transport and phosphorylation. Molecular and Cellular Biochemistry. 32: 153. DOI: 10.1007/Bf00227442  0.539
1979 Larner J, Galasko G, Cheng K, DePaoli-Roach AA, Huang L, Daggy P, Kellogg J. Generation by insulin of a chemical mediator that controls protein phosphorylation and dephosphorylation Science. 206: 1408-1410. PMID 228395 DOI: 10.1126/Science.228395  0.678
1979 Lawrence JC, Larner J. Control of glycogen synthase and phosphorylase by insulin in rat adipocytes which is unrelated to the concentration of cyclic AMP Biochimica Et Biophysica Acta. 582: 402-411. PMID 217439 DOI: 10.1016/0304-4165(79)90132-6  0.558
1978 Oron Y, Kellogg J, Larner J. Stable cholinergic-muscarinic inhibition of rat parotid adenylate cyclase. Febs Letters. 94: 331-334. PMID 212319 DOI: 10.1016/0014-5793(78)80969-7  0.305
1978 Guinovart JJ, Lawrence JC, Larner J. Hormonal effects on fat cell adenosine 3',5'-monophosphate dependent protein kinase. Biochimica Et Biophysica Acta. 539: 181-194. PMID 204358 DOI: 10.1016/0304-4165(78)90005-3  0.417
1978 Lawrence JC, Larner J, Kahn CR, Roth J. Autoantibodies to the insulin receptor activate glycogen synthase in rat adipocytes. Molecular and Cellular Biochemistry. 22: 153-158. PMID 106236 DOI: 10.1007/Bf00496241  0.526
1978 Walkenbach RJ, hazen R, Larner J. Reversible inhibition of cyclic AMP-dependent protein kinase by insulin Molecular and Cellular Biochemistry. 19: 31-41. PMID 25380 DOI: 10.1007/Bf00231232  0.507
1978 Lawrence J, Larner J. Activation of glycogen synthase in rat adipocytes by insulin and glucose involves increased glucose transport and phosphorylation. Journal of Biological Chemistry. 253: 2104-2113. DOI: 10.1016/s0021-9258(17)38046-8  0.406
1977 Roach PJ, Rosell-Perez M, Larner J. Muscle glycogen synthase in vivo state:. Effects of insulin administration on the chemical and kinetic properties of the purified enzyme Febs Letters. 80: 95-98. PMID 408195 DOI: 10.1016/0014-5793(77)80414-6  0.613
1977 Roach PJ, Larner J. Covalent phosphorylation in the regulation of glycogen synthase activity Molecular and Cellular Biochemistry. 15: 179-200. PMID 196178 DOI: 10.1007/Bf01734108  0.552
1976 Larner J, Takeda Y, Hizukuri S. The Influence Of Chain Size And Molecular Weight On The Kinetic Constants For The Span Glucose To Polysaccharide For Rabbit Muscle Glycogen Synthase Molecular and Cellular Biochemistry. 12: 131-136. PMID 824547 DOI: 10.1007/Bf01741711  0.365
1976 Ng FM, Larner J. Actions of Insulin-Potentiating Peptides on Glycogen Synthesis Diabetes. 25: 413-419. PMID 817952 DOI: 10.2337/Diab.25.5.413  0.482
1976 Roach PJ, Larner J. Regulation of glycogen synthase: A relation of enzymic properties with biological function Trends in Biochemical Sciences. 1: 110-112. DOI: 10.1016/0968-0004(76)90018-9  0.539
1975 Salsas E, Larner J. Action pattern of muscle glycogen synthase. Molecular and Cellular Biochemistry. 7: 195-199. PMID 807797 DOI: 10.1007/Bf01731409  0.365
1975 Larner J. Four questions times two: a dialogue on the mechanism of insulin action dedicated to Earl W. Sutherland. Metabolism-Clinical and Experimental. 24: 249-256. PMID 165348 DOI: 10.1016/0026-0495(75)90106-7  0.483
1973 Thomas JA, Schlender KK, Larner J. Specificity of activation of glycogen synthase I from skeletal muscle and heart Biochimica Et Biophysica Acta. 293: 84-93. PMID 4631038 DOI: 10.1016/0005-2744(73)90378-1  0.38
1973 Schlender KK, Larner J. Purification and properties of glycogen synthase I from skeletal muscle: Two kinetic forms Biochimica Et Biophysica Acta. 293: 73-83. PMID 4631037 DOI: 10.1016/0005-2744(73)90377-X  0.317
1973 Thomas JA, Larner J. Purification and properties of glycogen synthase I from bovine heart: two kinetic forms. Biochimica Et Biophysica Acta. 293: 62-72. PMID 4631036 DOI: 10.1016/0005-2744(73)90376-8  0.349
1973 Butcher RW, Crofford OB, Gammeltoff S, Gliemann J, Gavin JR, Goldfine ID, Kahn CR, Rodbell M, Roth J, Jarrett L, Larner J, Lefkowitz RJ, Levine R, Marinetti GV. Letter: Insulin activity: the solid matrix. Science (New York, N.Y.). 182: 396-8. PMID 4356902 DOI: 10.1126/Science.182.4110.396-A  0.461
1973 Miller TB, Hazen R, Larner J. An absolute requirement for insulin in the control of hepatic glycogenesis by glucose. Biochemical and Biophysical Research Communications. 53: 466-474. PMID 4197819 DOI: 10.1016/0006-291X(73)90685-2  0.49
1973 Rebhun LI, Smith C, Larner J. Electron microscope studies of glycogen synthase Molecular and Cellular Biochemistry. 1: 55-61. PMID 4139647 DOI: 10.1007/Bf01659938  0.327
1973 Miller TB, Larner J. Mechanism of Control of Hepatic Glycogenesis by Insulin Journal of Biological Chemistry. 248: 3483-3488. DOI: 10.1016/s0021-9258(19)43955-0  0.36
1973 Rosenkrans AM, Larner J. Proof of phosphorylation and evidence for different primary structure of phosphorylated sites of glycogen synthases from rabbit and frog tissues Biochimica Et Biophysica Acta. 315: 317-332. DOI: 10.1016/0005-2744(73)90260-X  0.324
1972 Smith CH, Larner J, Thomas AM, Kupchan SM. Inactivation of glycogen synthase by the tumor inhibitor vernolepin. Biochimica Et Biophysica Acta. 276: 94-104. PMID 5047713 DOI: 10.1016/0005-2744(72)90011-3  0.316
1972 Miller TB, Larner J. Anti-Insulin Actions of a Bovine Pituitary Diabetogenic Peptide on Glycogen Synthesis Proceedings of the National Academy of Sciences of the United States of America. 69: 2774-2777. PMID 4628094 DOI: 10.1073/Pnas.69.10.2774  0.47
1972 Larner J. Insulin And Glycogen Synthase Diabetes. 21: 428-438. PMID 4340998 DOI: 10.2337/Diab.21.2.S428  0.52
1971 Smith CH, Brown NE, Larner J. Molecular characteristics of the totally dependent and independent forms of glycogen synthase of rabbit skeletal muscle. II. Some chemical characteristics of the enzyme protein and of its change on interconversion. Biochimica Et Biophysica Acta. 242: 81-8. PMID 5121616 DOI: 10.1016/0005-2744(71)90089-1  0.337
1971 Larner J. A new nomenclature for kinase phosphatase catalyzed interconvertible enzymes. Annals of the New York Academy of Sciences. 185: 70-73. PMID 4330520 DOI: 10.1111/J.1749-6632.1971.Tb45237.X  0.329
1971 Nuttall FQ, Larner J. Studies of glycogen synthetase interconverting enzymes in in vitro perfused compared to non-perfused rat hearts Biochimica Et Biophysica Acta. 230: 560-570. PMID 4325680 DOI: 10.1016/0304-4165(71)90189-9  0.441
1971 Bishop JS, Goldberg ND, Larner J. Insulin regulation of hepatic glycogen metabolism in the dog. The American Journal of Physiology. 220: 499-506. PMID 4322344 DOI: 10.1152/ajplegacy.1971.220.2.499  0.345
1971 Larner J, Villar-Palasi C. Glycogen Synthase and Its Control Current Topics in Cellular Regulation. 3: 195-236. DOI: 10.1016/B978-0-12-152803-4.50010-5  0.455
1969 Craig JW, Rall TW, Larner J. The influence of insulin and epinephrine on adenosine 3′,5′-phosphate and glycogen transferase in muscle Bba - General Subjects. 177: 213-219. PMID 4305363  0.392
1967 Bishop JS, Larner J. Rapid Activation-Inactivation of Liver Uridine Diphosphate Glucose-Glycogen Transferase and Phosphorylase by Insulin and Glucagon in Vivo Journal of Biological Chemistry. 242: 1354-1356. DOI: 10.1016/s0021-9258(18)96188-0  0.415
1967 GOLDBERG N, VILLARPALASI C, SASKO H, LARNER J. Effects of insulin treatment on muscle 3′,5′-cyclic adenylate levels in vivo and in vitro Biochimica Et Biophysica Acta (Bba) - General Subjects. 148: 665-672. DOI: 10.1016/0304-4165(67)90039-6  0.35
1966 Villar-Palasi C, Rosell-Perez M, Hizukuri S, Huijing F, Larner J. [64] Muscle and liver UDP-glucose: α-1,4-glucan α-4-glucosyltransferase (glycogen synthetase) Methods in Enzymology. 8: 374-384. DOI: 10.1016/0076-6879(66)08068-6  0.441
1965 LARNER J, SANGER F. THE AMINO ACID SEQUENCE OF THE PHOSPHORYLATION SITE OF MUSCLE URIDINE DIPHOSPHOGLUCOSE ALPHA-1,4-GLUCAN ALPHA-4-GLUCOSYL TRANSFERASE. Journal of Molecular Biology. 11: 491-500. PMID 14267271 DOI: 10.1016/S0022-2836(65)80005-5  0.548
1965 Friedman DL, Larner J. Studies on Uridine Diphosphate Glucose:α-1,4-Glucan α-4-Glucosyltransferase. VIII. Catalysis of the Phosphorylation of Muscle Phosphorylase and Transferase by Separate Enzymes* Biochemistry. 4: 2261-2264. DOI: 10.1021/Bi00887A001  0.382
1964 Hizukuri S, Larner J. Studies on UDPG: α-1,4-Glucan α-4-Glucosyltransferase. VII. Conversion of the Enzyme from Glucose-6-phosphate-dependent to Independent Form in Liver* Biochemistry. 3: 1783-1788. PMID 14235348 DOI: 10.1021/Bi00899A034  0.348
1964 CRAIG JW, LARNER J. INFLUENCE OF EPINEPHRINE AND INSULIN ON URIDINE DIPHOSPHATE GLUCOSE-ALPHA-GLUCAN TRANSFERASE AND PHOSPHORYLASE IN MUSCLE. Nature. 202: 971-3. PMID 14197328 DOI: 10.1038/202971A0  0.37
1951 CORI GT, LARNER J. Action of amylo-1,6-glucosidase and phosphorylase on glycogen and amylopectin. The Journal of Biological Chemistry. 188: 17-29. PMID 14814109  0.603
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