| Year |
Citation |
Score |
| 2022 |
Procopiou G, Jackson PJM, di Mascio D, Auer JL, Pepper C, Rahman KM, Fox KR, Thurston DE. DNA sequence-selective G-A cross-linking ADC payloads for use in solid tumour therapies. Communications Biology. 5: 741. PMID 35906376 DOI: 10.1038/s42003-022-03633-0 |
0.751 |
|
| 2020 |
Pysz I, Jackson PJM, Barlow DJ, Rahman KM, Thurston DE. UPLC-based assay to assess the hydrophobicity of Antibody-Drug Conjugate (ADC) payloads. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1146: 122075. PMID 32361467 DOI: 10.1016/J.Jchromb.2020.122075 |
0.742 |
|
| 2020 |
Hoffmann RM, Crescioli S, Mele S, Sachouli E, Cheung A, Chui CK, Andriollo P, Jackson PJM, Lacy KE, Spicer JF, Thurston DE, Karagiannis SN. A Novel Antibody-Drug Conjugate (ADC) Delivering a DNA Mono-Alkylating Payload to Chondroitin Sulfate Proteoglycan (CSPG4)-Expressing Melanoma. Cancers. 12. PMID 32331483 DOI: 10.3390/Cancers12041029 |
0.688 |
|
| 2019 |
Thirlway J, Lodge A, Pelava A, Williamson D, Carta D, Nakeeb MA, Mysliwy J, Jackson P, Thurston D, Lutz R. IKS01, a next generation antibody drug conjugate (ADC) designed to be efficacious in tumors with low and moderate levels of folate receptor expression Annals of Oncology. 30: v16-v17. DOI: 10.1093/Annonc/Mdz238.056 |
0.555 |
|
| 2018 |
Jackson PJM, Kay S, Pysz I, Thurston DE. Use of pyrrolobenzodiazepines and related covalent-binding DNA-interactive molecules as ADC payloads: Is mechanism related to systemic toxicity? Drug Discovery Today. Technologies. 30: 71-83. PMID 30553523 DOI: 10.1016/J.Ddtec.2018.10.004 |
0.776 |
|
| 2018 |
Islam MK, Jackson PJM, Thurston DE, Rahman KM. Methylene-linked bis-phenylbenzimidazoles - a new scaffold to target telomeric DNA/RNA hybrid duplex. Organic & Biomolecular Chemistry. PMID 29498732 DOI: 10.1039/C7Ob02709E |
0.728 |
|
| 2017 |
Basher MA, Rahman KM, Jackson PJM, Thurston DE, Fox KR. Sequence-selective binding of C8-conjugated pyrrolobenzodiazepines (PBDs) to DNA. Biophysical Chemistry. PMID 28941814 DOI: 10.1016/J.Bpc.2017.08.006 |
0.738 |
|
| 2016 |
Jackson PJ, Rahman KM, Thurston DE. The use of molecular dynamics simulations to evaluate the DNA sequence-selectivity of G-A cross-linking PBD-duocarmycin dimers. Bioorganic & Medicinal Chemistry Letters. PMID 27889454 DOI: 10.1016/J.Bmcl.2016.10.022 |
0.711 |
|
| 2016 |
Mantaj J, Jackson PJ, Rahman KM, Thurston DE. From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs). Angewandte Chemie (International Ed. in English). PMID 27862776 DOI: 10.1002/Anie.201510610 |
0.79 |
|
| 2016 |
Mantaj J, Jackson PJ, Karu K, Rahman KM, Thurston DE. Covalent Bonding of Pyrrolobenzodiazepines (PBDs) to Terminal Guanine Residues within Duplex and Hairpin DNA Fragments. Plos One. 11: e0152303. PMID 27055050 DOI: 10.1371/Journal.Pone.0152303 |
0.795 |
|
| 2015 |
Thurston DE, Vassoler H, Jackson PJ, James CH, Rahman KM. Effect of hairpin loop structure on reactivity, sequence preference and adduct orientation of a DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumour agent. Organic & Biomolecular Chemistry. 13: 4031-40. PMID 25733051 DOI: 10.1039/C4Ob02405B |
0.741 |
|
| 2015 |
Mantaj J, Rahman SM, Bokshi B, Hasan CM, Jackson PJ, Parsons RB, Rahman KM. Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast cancer cells. Organic & Biomolecular Chemistry. 13: 3882-6. PMID 25721973 DOI: 10.1039/C5Ob00052A |
0.754 |
|
| 2014 |
Rahman KM, Corcoran DB, Bui TT, Jackson PJ, Thurston DE. Pyrrolobenzodiazepines (PBDs) do not bind to DNA G-quadruplexes. Plos One. 9: e105021. PMID 25133504 DOI: 10.1371/Journal.Pone.0105021 |
0.798 |
|
| 2014 |
Jackson PJ, James CH, Jenkins TC, Rahman KM, Thurston DE. Computational studies support the role of the C7-sibirosamine sugar of the pyrrolobenzodiazepine (PBD) sibiromycin in transcription factor inhibition. Acs Chemical Biology. 9: 2432-40. PMID 25111266 DOI: 10.1021/Cb5002203 |
0.758 |
|
| 2014 |
Nahar KS, Chamberlain C, Grover A, Jackson P, Rahman KM, Thurston DE. Abstract 1624: A fragment-based approach to the development of small-molecule STAT3 transcription factor inhibitors Cancer Research. 74: 1624-1624. DOI: 10.1158/1538-7445.Am2014-1624 |
0.778 |
|
| 2014 |
Mantaj J, Jackson P, Thurston D, Rahman K. 42 Interaction of SJG-136 with cognate sequences of oncogenic transcription factors European Journal of Cancer. 50: 19. DOI: 10.1016/S0959-8049(14)70168-6 |
0.736 |
|
| 2013 |
Brucoli F, Hawkins RM, James CH, Jackson PJ, Wells G, Jenkins TC, Ellis T, Kotecha M, Hochhauser D, Hartley JA, Howard PW, Thurston DE. An extended pyrrolobenzodiazepine-polyamide conjugate with selectivity for a DNA sequence containing the ICB2 transcription factor binding site. Journal of Medicinal Chemistry. 56: 6339-51. PMID 23889553 DOI: 10.1021/Jm4001852 |
0.766 |
|
| 2013 |
Heidelberger S, Zinzalla G, Antonow D, Essex S, Basu BP, Palmer J, Husby J, Jackson PJ, Rahman KM, Wilderspin AF, Zloh M, Thurston DE. Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry. Bioorganic & Medicinal Chemistry Letters. 23: 4719-22. PMID 23810499 DOI: 10.1016/J.Bmcl.2013.05.066 |
0.667 |
|
| 2013 |
Rahman KM, Jackson PJ, James CH, Basu BP, Hartley JA, de la Fuente M, Schatzlein A, Robson M, Pedley RB, Pepper C, Fox KR, Howard PW, Thurston DE. GC-targeted C8-linked pyrrolobenzodiazepine-biaryl conjugates with femtomolar in vitro cytotoxicity and in vivo antitumor activity in mouse models. Journal of Medicinal Chemistry. 56: 2911-35. PMID 23514599 DOI: 10.1021/Jm301882A |
0.759 |
|
| 2011 |
Lim HK, Chen J, Sensenhauser C, Cook K, Preston R, Thomas T, Shook B, Jackson PF, Rassnick S, Rhodes K, Gopaul V, Salter R, Silva J, Evans DC. Overcoming the genotoxicity of a pyrrolidine substituted arylindenopyrimidine as a potent dual adenosine A(2A)/A(1) antagonist by minimizing bioactivation to an iminium ion reactive intermediate. Chemical Research in Toxicology. 24: 1012-30. PMID 21667953 DOI: 10.1021/tx1004437 |
0.305 |
|
| 1978 |
Cress DE, Jackson PJ, Kadouri A, Chu YE, Lark KG. DNA replication in soybean protoplasts and suspension-cultured cells: Comparison of exponential and fluorodeoxyuridine synchronized cultures. Planta. 143: 241-53. PMID 24408461 DOI: 10.1007/Bf00391994 |
0.301 |
|
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