| Year |
Citation |
Score |
| 2023 |
Hoarau M, Sermmai P, Varatthan T, Thiabma R, Jantra T, Rattanajak R, Vitsupakorn D, Vanichtanankul J, Saepua S, Yuthavong Y, Thongpanchang C, Kamchonwongpaisan S. Discovery of rigid biphenyl DHFR inhibitors using a fragment linking strategy. Rsc Medicinal Chemistry. 14: 1755-1766. PMID 37731689 DOI: 10.1039/d3md00242j |
0.346 |
|
| 2022 |
Vanichtanankul J, Yoomuang A, Taweechai S, Saeyang T, Pengon J, Yuvaniyama J, Tarnchompoo B, Yuthavong Y, Kamchonwongpaisan S. Structural Insight into Effective Inhibitors' Binding to Dihydrofolate Reductase Thymidylate Synthase. Acs Chemical Biology. PMID 35715223 DOI: 10.1021/acschembio.1c00627 |
0.326 |
|
| 2022 |
Hoarau M, Suwanakitti N, Varatthan T, Thiabma R, Rattanajak R, Charoensetakul N, Redman EK, Khotavivattana T, Vilaivan T, Yuthavong Y, Kamchonwongpaisan S. Assay Development and Identification of the First 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Inhibitors. Molecules (Basel, Switzerland). 27. PMID 35684452 DOI: 10.3390/molecules27113515 |
0.596 |
|
| 2021 |
Posayapisit N, Pengon J, Prommana P, Shoram M, Yuthavong Y, Uthaipibull C, Kamchonwongpaisan S, Jupatanakul N. Transgenic pyrimethamine-resistant plasmodium falciparum reveals transmission-blocking potency of P218, a novel antifolate candidate drug. International Journal For Parasitology. PMID 33713651 DOI: 10.1016/j.ijpara.2020.12.002 |
0.317 |
|
| 2020 |
Kamchonwongpaisan S, Charoensetakul N, Srisuwannaket C, Taweechai S, Rattanajak R, Vanichtanankul J, Vitsupakorn D, Arwon U, Thongpanchang C, Tarnchompoo B, Vilaivan T, Yuthavong Y. Flexible diaminodihydrotriazine inhibitors of Plasmodium falciparum dihydrofolate reductase: Binding strengths, modes of binding and their antimalarial activities. European Journal of Medicinal Chemistry. 195: 112263. PMID 32294614 DOI: 10.1016/J.Ejmech.2020.112263 |
0.673 |
|
| 2020 |
Chitnumsub P, Jaruwat A, Talawanich Y, Noytanom K, Liwnaree B, Poen S, Yuthavong Y. The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance. The Febs Journal. 287: 3273-3297. PMID 31883412 DOI: 10.2210/Pdb6Jwz/Pdb |
0.47 |
|
| 2019 |
Saepua S, Sadorn K, Vanichtanankul J, Anukunwithaya T, Rattanajak R, Vitsupakorn D, Kamchonwongpaisan S, Yuthavong Y, Thongpanchang C. 6-Hydrophobic aromatic substituent pyrimethamine analogues as potential antimalarials for pyrimethamine-resistant Plasmodium falciparum. Bioorganic & Medicinal Chemistry. 27: 115158. PMID 31685330 DOI: 10.1016/J.Bmc.2019.115158 |
0.479 |
|
| 2019 |
Jaruwat A, Riangrungroj P, Ubonprasert S, Sae-Ueng U, Kuaprasert B, Yuthavong Y, Leartsakulpanich U, Chitnumsub P. Crystal structure of Plasmodium falciparum adenosine deaminase reveals a novel binding pocket for inosine. Archives of Biochemistry and Biophysics. 667: 6-13. PMID 31002765 DOI: 10.1016/J.Abb.2019.04.002 |
0.45 |
|
| 2018 |
Tarnchompoo B, Chitnumsub P, Jaruwat A, Shaw PJ, Vanichtanankul J, Poen S, Rattanajak R, Wongsombat C, Tonsomboon A, Decharuangsilp S, Anukunwithaya T, Arwon U, Kamchonwongpaisan S, Yuthavong Y. Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance. Acs Medicinal Chemistry Letters. 9: 1235-1240. PMID 30613332 DOI: 10.1021/Acsmedchemlett.8B00389 |
0.455 |
|
| 2018 |
Ittarat W, Pornthanakasem W, Mungthin M, Suwandittakul N, Leelayoova S, Tarnchompoo B, Yuthavong Y, Kongkasuriyachai D, Leartsakulpanich U. Characterization of Plasmodium knowlesi dihydrofolate reductase-thymidylate synthase and sensitivity to antifolates. Parasitology International. PMID 30114522 DOI: 10.1016/J.Parint.2018.08.004 |
0.419 |
|
| 2016 |
Posayapisit N, Songsungthong W, Koonyosying P, Falade M, Uthaipibull C, Yuthavong Y, Shaw PJ, Kamchonwongpaisana S. Cytochrome c and c1 heme lyases are essential in Plasmodium berghei. Molecular and Biochemical Parasitology. PMID 27520480 DOI: 10.1016/J.Molbiopara.2016.08.003 |
0.33 |
|
| 2016 |
Lourens AC, Gravestock D, van Zyl RL, Hoppe HC, Kolesnikova N, Taweechai S, Yuthavong Y, Kamchonwongpaisan S, Rousseau AL. Design, synthesis and biological evaluation of 6-aryl-1,6-dihydro-1,3,5-triazine-2,4-diamines as antiplasmodial antifolates. Organic & Biomolecular Chemistry. 14: 7899-911. PMID 27477595 DOI: 10.1039/C6Ob01350C |
0.415 |
|
| 2016 |
Pornthanakasem W, Riangrungroj P, Chitnumsub P, Ittarat W, Kongkasuriyachai D, Uthaipibull C, Yuthavong Y, Leartsakulpanich U. Evaluation for the role of Plasmodium vivax dihydropteroate synthase polymorphisms in sulfa drug resistance. Antimicrobial Agents and Chemotherapy. PMID 27161627 DOI: 10.1128/Aac.01835-15 |
0.499 |
|
| 2016 |
Aroonsri A, Akinola O, Posayapisit N, Songsungthong W, Uthaipibull C, Kamchonwongpaisan S, Gbotosho GO, Yuthavong Y, Shaw PJ. Identifying antimalarial compounds targeting dihydrofolate reductase-thymidylate synthase (DHFR-TS) by chemogenomic profiling. International Journal For Parasitology. PMID 27150044 DOI: 10.1016/J.Ijpara.2016.04.002 |
0.409 |
|
| 2015 |
Shaw PJ, Chaotheing S, Kaewprommal P, Piriyapongsa J, Wongsombat C, Suwannakitti N, Koonyosying P, Uthaipibull C, Yuthavong Y, Kamchonwongpaisan S. Plasmodium parasites mount an arrest response to dihydroartemisinin, as revealed by whole transcriptome shotgun sequencing (RNA-seq) and microarray study. Bmc Genomics. 16: 830. PMID 26490244 DOI: 10.1186/S12864-015-2040-0 |
0.36 |
|
| 2015 |
Talawanich Y, Kamchonwongpaisan S, Sirawaraporn W, Yuthavong Y. Use of bacterial surrogates as a tool to explore antimalarial drug interaction: Synergism between inhibitors of malarial dihydrofolate reductase and dihydropteroate synthase. Acta Tropica. 149: 64-9. PMID 25997881 DOI: 10.1016/J.Actatropica.2015.05.011 |
0.404 |
|
| 2015 |
Witschel MC, Rottmann M, Schwab A, Leartsakulpanich U, Chitnumsub P, Seet M, Tonazzi S, Schwertz G, Stelzer F, Mietzner T, McNamara C, Thater F, Freymond C, Jaruwat A, Pinthong C, ... ... Yuthavong Y, et al. Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities. Journal of Medicinal Chemistry. 58: 3117-30. PMID 25785478 DOI: 10.1021/Jm501987H |
0.415 |
|
| 2015 |
Maenpuen S, Amornwatcharapong W, Krasatong P, Sucharitakul J, Palfey BA, Yuthavong Y, Chitnumsub P, Leartsakulpanich U, Chaiyen P. Kinetic mechanism and the rate-limiting step of Plasmodium vivax serine hydroxymethyltransferase. The Journal of Biological Chemistry. 290: 8656-65. PMID 25678710 DOI: 10.1074/Jbc.M114.612275 |
0.337 |
|
| 2014 |
Chitnumsub P, Jaruwat A, Riangrungroj P, Ittarat W, Noytanom K, Oonanant W, Vanichthanankul J, Chuankhayan P, Maenpuen S, Chen CJ, Chaiyen P, Yuthavong Y, Leartsakulpanich U. Structures of Plasmodium vivax serine hydroxymethyltransferase: implications for ligand-binding specificity and functional control. Acta Crystallographica. Section D, Biological Crystallography. 70: 3177-86. PMID 25478836 DOI: 10.1107/S1399004714023128 |
0.41 |
|
| 2014 |
Wongsombat C, Aroonsri A, Kamchonwongpaisan S, Morgan HP, Walkinshaw MD, Yuthavong Y, Shaw PJ. Molecular characterization of Plasmodium falciparum Bruno/CELF RNA binding proteins. Molecular and Biochemical Parasitology. 198: 1-10. PMID 25447287 DOI: 10.1016/J.Molbiopara.2014.10.005 |
0.301 |
|
| 2014 |
Yongkiettrakul S, Jaroenram W, Arunrut N, Chareanchim W, Pannengpetch S, Suebsing R, Kiatpathomchai W, Pornthanakasem W, Yuthavong Y, Kongkasuriyachai D. Application of loop-mediated isothermal amplification assay combined with lateral flow dipstick for detection of Plasmodium falciparum and Plasmodium vivax. Parasitology International. 63: 777-84. PMID 25038579 DOI: 10.1016/J.Parint.2014.06.004 |
0.301 |
|
| 2014 |
Chitnumsub P, Ittarat W, Jaruwat A, Noytanom K, Amornwatcharapong W, Pornthanakasem W, Chaiyen P, Yuthavong Y, Leartsakulpanich U. The structure of Plasmodium falciparum serine hydroxymethyltransferase reveals a novel redox switch that regulates its activities. Acta Crystallographica. Section D, Biological Crystallography. 70: 1517-27. PMID 24914963 DOI: 10.1107/S1399004714005598 |
0.437 |
|
| 2014 |
Kümpornsin K, Kotanan N, Chobson P, Kochakarn T, Jirawatcharadech P, Jaru-ampornpan P, Yuthavong Y, Chookajorn T. Biochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase I. Malaria Journal. 13: 150. PMID 24745605 DOI: 10.1186/1475-2875-13-150 |
0.464 |
|
| 2014 |
Kümpornsin K, Modchang C, Heinberg A, Ekland EH, Jirawatcharadech P, Chobson P, Suwanakitti N, Chaotheing S, Wilairat P, Deitsch KW, Kamchonwongpaisan S, Fidock DA, Kirkman LA, Yuthavong Y, Chookajorn T. Origin of robustness in generating drug-resistant malaria parasites. Molecular Biology and Evolution. 31: 1649-60. PMID 24739308 DOI: 10.1093/Molbev/Msu140 |
0.446 |
|
| 2014 |
Mokmak W, Chunsrivirot S, Hannongbua S, Yuthavong Y, Tongsima S, Kamchonwongpaisan S. Molecular dynamics of interactions between rigid and flexible antifolates and dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant Plasmodium falciparum. Chemical Biology & Drug Design. 84: 450-61. PMID 24716467 DOI: 10.1111/Cbdd.12334 |
0.432 |
|
| 2014 |
Pinthong C, Maenpuen S, Amornwatcharapong W, Yuthavong Y, Leartsakulpanich U, Chaiyen P. Distinct biochemical properties of human serine hydroxymethyltransferase compared with the Plasmodium enzyme: implications for selective inhibition. The Febs Journal. 281: 2570-83. PMID 24698160 DOI: 10.1111/Febs.12803 |
0.42 |
|
| 2013 |
Hooft van Huijsduijnen R, Guy RK, Chibale K, Haynes RK, Peitz I, Kelter G, Phillips MA, Vennerstrom JL, Yuthavong Y, Wells TN. Anticancer properties of distinct antimalarial drug classes. Plos One. 8: e82962. PMID 24391728 DOI: 10.1371/Journal.Pone.0082962 |
0.373 |
|
| 2013 |
Prommana P, Uthaipibull C, Wongsombat C, Kamchonwongpaisan S, Yuthavong Y, Knuepfer E, Holder AA, Shaw PJ. Inducible knockdown of Plasmodium gene expression using the glmS ribozyme. Plos One. 8: e73783. PMID 24023691 DOI: 10.1371/Journal.Pone.0073783 |
0.341 |
|
| 2012 |
Pornthanakasem W, Kongkasuriyachai D, Uthaipibull C, Yuthavong Y, Leartsakulpanich U. Plasmodium serine hydroxymethyltransferase: indispensability and display of distinct localization. Malaria Journal. 11: 387. PMID 23173711 DOI: 10.1186/1475-2875-11-387 |
0.396 |
|
| 2012 |
Yuthavong Y, Tarnchompoo B, Vilaivan T, Chitnumsub P, Kamchonwongpaisan S, Charman SA, McLennan DN, White KL, Vivas L, Bongard E, Thongphanchang C, Taweechai S, Vanichtanankul J, Rattanajak R, Arwon U, et al. Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target. Proceedings of the National Academy of Sciences of the United States of America. 109: 16823-8. PMID 23035243 DOI: 10.1073/Pnas.1204556109 |
0.668 |
|
| 2012 |
Sopitthummakhun K, Thongpanchang C, Vilaivan T, Yuthavong Y, Chaiyen P, Leartsakulpanich U. Plasmodium serine hydroxymethyltransferase as a potential anti-malarial target: inhibition studies using improved methods for enzyme production and assay. Malaria Journal. 11: 194. PMID 22691309 DOI: 10.1186/1475-2875-11-194 |
0.619 |
|
| 2012 |
Vanichtanankul J, Taweechai S, Uttamapinant C, Chitnumsub P, Vilaivan T, Yuthavong Y, Kamchonwongpaisan S. Combined spatial limitation around residues 16 and 108 of Plasmodium falciparum dihydrofolate reductase explains resistance to cycloguanil. Antimicrobial Agents and Chemotherapy. 56: 3928-35. PMID 22526319 DOI: 10.1128/Aac.00301-12 |
0.629 |
|
| 2012 |
Tirakarn S, Riangrungroj P, Kongsaeree P, Imwong M, Yuthavong Y, Leartsakulpanich U. Cloning and heterologous expression of Plasmodium ovale dihydrofolate reductase-thymidylate synthase gene. Parasitology International. 61: 324-32. PMID 22234170 DOI: 10.1016/J.Parint.2011.12.004 |
0.451 |
|
| 2012 |
Somsak V, Srichairatanakool S, Yuthavong Y, Kamchonwongpaisan S, Uthaipibull C. Flow cytometric enumeration of Plasmodium berghei-infected red blood cells stained with SYBR Green I. Acta Tropica. 122: 113-8. PMID 22222185 DOI: 10.1016/J.Actatropica.2011.12.010 |
0.325 |
|
| 2011 |
Somsak V, Uthaipibull C, Prommana P, Srichairatanakool S, Yuthavong Y, Kamchonwongpaisan S. Transgenic Plasmodium parasites stably expressing Plasmodium vivax dihydrofolate reductase-thymidylate synthase as in vitro and in vivo models for antifolate screening. Malaria Journal. 10: 291. PMID 21981896 DOI: 10.1186/1475-2875-10-291 |
0.409 |
|
| 2011 |
Vanichtanankul J, Taweechai S, Yuvaniyama J, Vilaivan T, Chitnumsub P, Kamchonwongpaisan S, Yuthavong Y. Trypanosomal dihydrofolate reductase reveals natural antifolate resistance. Acs Chemical Biology. 6: 905-11. PMID 21650210 DOI: 10.1021/Cb200124R |
0.656 |
|
| 2011 |
Tipsuwan W, Srichairatanakool S, Kamchonwongpaisan S, Yuthavong Y, Uthaipibull C. Selection of drug resistant mutants from random library of Plasmodium falciparum dihydrofolate reductase in Plasmodium berghei model. Malaria Journal. 10: 119. PMID 21554743 DOI: 10.1186/1475-2875-10-119 |
0.42 |
|
| 2011 |
Chanama M, Chanama S, Shaw PJ, Chitnumsub P, Leartsakulpanich U, Yuthavong Y. Formation of catalytically active cross-species heterodimers of thymidylate synthase from Plasmodium falciparum and Plasmodium vivax. Molecular Biology Reports. 38: 1029-37. PMID 20577818 DOI: 10.1007/S11033-010-0199-7 |
0.389 |
|
| 2010 |
Nzila A, Rottmann M, Chitnumsub P, Kiara SM, Kamchonwongpaisan S, Maneeruttanarungroj C, Taweechai S, Yeung BK, Goh A, Lakshminarayana SB, Zou B, Wong J, Ma NL, Weaver M, Keller TH, ... ... Yuthavong Y, et al. Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate. Antimicrobial Agents and Chemotherapy. 54: 2603-10. PMID 20350951 DOI: 10.1128/Aac.01526-09 |
0.449 |
|
| 2009 |
Chitnumsub P, Yuvaniyama J, Chahomchuen T, Vilaivan T, Yuthavong Y. Crystallization and preliminary crystallographic studies of dihydrofolate reductase-thymidylate synthase from Trypanosoma cruzi, the Chagas disease pathogen. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 65: 1175-8. PMID 19923744 DOI: 10.1107/S1744309109041979 |
0.541 |
|
| 2009 |
Maenpuen S, Sopitthummakhun K, Yuthavong Y, Chaiyen P, Leartsakulpanich U. Characterization of Plasmodium falciparum serine hydroxymethyltransferase-A potential antimalarial target. Molecular and Biochemical Parasitology. 168: 63-73. PMID 19591881 DOI: 10.1016/J.Molbiopara.2009.06.010 |
0.392 |
|
| 2009 |
Sopitthummakhun K, Maenpuen S, Yuthavong Y, Leartsakulpanich U, Chaiyen P. Serine hydroxymethyltransferase from Plasmodium vivax is different in substrate specificity from its homologues. The Febs Journal. 276: 4023-36. PMID 19549189 DOI: 10.1111/J.1742-4658.2009.07111.X |
0.365 |
|
| 2009 |
Maitarad P, Kamchonwongpaisan S, Vanichtanankul J, Vilaivan T, Yuthavong Y, Hannongbua S. Interactions between cycloguanil derivatives and wild type and resistance-associated mutant Plasmodium falciparum dihydrofolate reductases. Journal of Computer-Aided Molecular Design. 23: 241-52. PMID 19156529 DOI: 10.1007/S10822-008-9254-Z |
0.631 |
|
| 2009 |
Dasgupta T, Chitnumsub P, Kamchonwongpaisan S, Maneeruttanarungroj C, Nichols SE, Lyons TM, Tirado-Rives J, Jorgensen WL, Yuthavong Y, Anderson KS. Exploiting structural analysis, in silico screening, and serendipity to identify novel inhibitors of drug-resistant falciparum malaria. Acs Chemical Biology. 4: 29-40. PMID 19146480 DOI: 10.1021/Cb8002804 |
0.49 |
|
| 2009 |
Maitarad P, Saparpakorn P, Hannongbua S, Kamchonwongpaisan S, Tarnchompoo B, Yuthavong Y. Particular interaction between pyrimethamine derivatives and quadruple mutant type dihydrofolate reductase of Plasmodium falciparum: CoMFA and quantum chemical calculations studies. Journal of Enzyme Inhibition and Medicinal Chemistry. 24: 471-9. PMID 18608776 DOI: 10.1080/14756360802201223 |
0.346 |
|
| 2008 |
Ganesan K, Ponmee N, Jiang L, Fowble JW, White J, Kamchonwongpaisan S, Yuthavong Y, Wilairat P, Rathod PK. A genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolates. Plos Pathogens. 4: e1000214. PMID 19023412 DOI: 10.1371/Journal.Ppat.1000214 |
0.36 |
|
| 2008 |
Leartsakulpanich U, Kongkasuriyachai D, Imwong M, Chotivanich K, Yuthavong Y. Cloning and characterization of Plasmodium vivax serine hydroxymethyltransferase. Parasitology International. 57: 223-8. PMID 18096429 DOI: 10.1016/J.Parint.2007.11.001 |
0.382 |
|
| 2007 |
Japrung D, Leartsakulpanich U, Chusacultanachai S, Yuthavong Y. Conflicting requirements of Plasmodium falciparum dihydrofolate reductase mutations conferring resistance to pyrimethamine-WR99210 combination. Antimicrobial Agents and Chemotherapy. 51: 4356-60. PMID 17875995 DOI: 10.1128/Aac.00577-07 |
0.434 |
|
| 2007 |
Thongpanchang C, Taweechai S, Kamchonwongpaisan S, Yuthavong Y, Thebtaranonth Y. Immobilization of malarial (Plasmodium falciparum) dihydrofolate reductase for the selection of tight-binding inhibitors from combinatorial library. Analytical Chemistry. 79: 5006-12. PMID 17530740 DOI: 10.1021/Ac070215S |
0.401 |
|
| 2007 |
Ponmee N, Chuchue T, Wilairat P, Yuthavong Y, Kamchonwongpaisan S. Artemisinin effectiveness in erythrocytes is reduced by heme and heme-containing proteins. Biochemical Pharmacology. 74: 153-60. PMID 17498668 DOI: 10.1016/J.Bcp.2007.03.008 |
0.317 |
|
| 2007 |
Kamchonwongpaisan S, Vanichtanankul J, Taweechai S, Chitnumsub P, Yuthavong Y. The role of tryptophan-48 in catalysis and binding of inhibitors of Plasmodium falciparum dihydrofolate reductase. International Journal For Parasitology. 37: 787-93. PMID 17320089 DOI: 10.1016/J.Ijpara.2006.12.017 |
0.477 |
|
| 2006 |
Yuthavong Y, Kamchonwongpaisan S, Leartsakulpanich U, Chitnumsub P. Folate metabolism as a source of molecular targets for antimalarials. Future Microbiology. 1: 113-25. PMID 17661690 DOI: 10.2217/17460913.1.1.113 |
0.454 |
|
| 2006 |
Bunyarataphan S, Leartsakulpanich U, Taweechai S, Tarnchompoo B, Kamchonwongpaisan S, Yuthavong Y. Evaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays. Antimicrobial Agents and Chemotherapy. 50: 3631-7. PMID 16954316 DOI: 10.1128/Aac.00448-06 |
0.516 |
|
| 2005 |
Kongsaeree P, Khongsuk P, Leartsakulpanich U, Chitnumsub P, Tarnchompoo B, Walkinshaw MD, Yuthavong Y. Crystal structure of dihydrofolate reductase from Plasmodium vivax: pyrimethamine displacement linked with mutation-induced resistance. Proceedings of the National Academy of Sciences of the United States of America. 102: 13046-51. PMID 16135570 DOI: 10.1073/Pnas.0501747102 |
0.474 |
|
| 2005 |
Japrung D, Chusacultanachai S, Yuvaniyama J, Wilairat P, Yuthavong Y. A simple dual selection for functionally active mutants of Plasmodium falciparum dihydrofolate reductase with improved solubility. Protein Engineering, Design & Selection : Peds. 18: 457-64. PMID 16120637 DOI: 10.1093/Protein/Gzi044 |
0.394 |
|
| 2005 |
Yuthavong Y, Yuvaniyama J, Chitnumsub P, Vanichtanankul J, Chusacultanachai S, Tarnchompoo B, Vilaivan T, Kamchonwongpaisan S. Malarial (Plasmodium falciparum) dihydrofolate reductase-thymidylate synthase: Structural basis for antifolate resistance and development of effective inhibitors Parasitology. 130: 249-259. PMID 15796007 DOI: 10.1017/S003118200400664X |
0.688 |
|
| 2005 |
Kamchonwongpaisan S, Vanichtanankul J, Tarnchompoo B, Yuvaniyama J, Taweechai S, Yuthavong Y. Stoichiometric selection of tight-binding inhibitors by wild-type and mutant forms of malarial (Plasmodium falciparum) dihydrofolate reductase. Analytical Chemistry. 77: 1222-7. PMID 15732900 DOI: 10.1021/Ac0487597 |
0.419 |
|
| 2005 |
Chanama M, Chitnumsub P, Yuthavong Y. Subunit complementation of thymidylate synthase in Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase. Molecular and Biochemical Parasitology. 139: 83-90. PMID 15610822 DOI: 10.1016/J.Molbiopara.2004.09.010 |
0.421 |
|
| 2004 |
Chitnumsub P, Yuvaniyama J, Yavaniyama J, Vanichtanankul J, Kamchonwongpaisan S, Walkinshaw MD, Yuthavong Y. Characterization, crystallization and preliminary X-ray analysis of bifunctional dihydrofolate reductase-thymidylate synthase from Plasmodium falciparum. Acta Crystallographica. Section D, Biological Crystallography. 60: 780-3. PMID 15039585 DOI: 10.1107/S0907444904001544 |
0.338 |
|
| 2004 |
Kamchonwongpaisan S, Quarrell R, Charoensetakul N, Ponsinet R, Vilaivan T, Vanichtanankul J, Tarnchompoo B, Sirawaraporn W, Lowe G, Yuthavong Y. Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities. Journal of Medicinal Chemistry. 47: 673-80. PMID 14736247 DOI: 10.1021/Jm030165T |
0.707 |
|
| 2004 |
Sirichaiwat C, Intaraudom C, Kamchonwongpaisan S, Vanichtanankul J, Thebtaranonth Y, Yuthavong Y. Target guided synthesis of 5-benzyl-2,4-diamonopyrimidines: their antimalarial activities and binding affinities to wild type and mutant dihydrofolate reductases from Plasmodium falciparum. Journal of Medicinal Chemistry. 47: 345-54. PMID 14711307 DOI: 10.1021/Jm0303352 |
0.473 |
|
| 2003 |
Yuvaniyama J, Chitnumsub P, Kamchonwongpaisan S, Vanichtanankul J, Sirawaraporn W, Taylor P, Walkinshaw MD, Yuthavong Y. Insights into antifolate resistance from malarial DHFR-TS structures. Nature Structural Biology. 10: 357-65. PMID 12704428 DOI: 10.1038/Nsb921 |
0.464 |
|
| 2003 |
Wattanarangsan J, Chusacultanachai S, Yuvaniyama J, Kamchonwongpaisan S, Yuthavong Y. Effect of N-terminal truncation of Plasmodium falciparum dihydrofolate reductase on dihydrofolate reductase and thymidylate synthase activity. Molecular and Biochemical Parasitology. 126: 97-102. PMID 12554089 DOI: 10.1016/S0166-6851(02)00240-2 |
0.35 |
|
| 2003 |
Vilaivan T, Saesaengseerung N, Jarprung D, Kamchonwongpaisan S, Sirawaraporn W, Yuthavong Y. Synthesis of solution-phase combinatorial library of 4,6-diamino-1,2-dihydro-1,3,5-triazine and identification of new leads against A16V+S108T mutant dihydrofolate reductase of Plasmodium falciparum. Bioorganic & Medicinal Chemistry. 11: 217-24. PMID 12470716 DOI: 10.1016/S0968-0896(02)00344-9 |
0.601 |
|
| 2002 |
Vattanaviboon P, Siritanaratkul N, Ketpirune J, Wilairat P, Yuthavong Y. Membrane heme as a host factor in reducing effectiveness of dihydroartemisinin. Biochemical Pharmacology. 64: 91-8. PMID 12106609 DOI: 10.1016/S0006-2952(02)01060-2 |
0.327 |
|
| 2002 |
Sirawaraporn W, Sirawaraporn R, Yongkiettrakul S, Anuwatwora A, Rastelli G, Kamchonwongpaisan S, Yuthavong Y. Mutational analysis of Plasmodium falciparum dihydrofolate reductase: the role of aspartate 54 and phenylalanine 223 on catalytic activity and antifolate binding. Molecular and Biochemical Parasitology. 121: 185-93. PMID 12034452 DOI: 10.1016/S0166-6851(02)00035-X |
0.428 |
|
| 2002 |
Tarnchompoo B, Sirichaiwat C, Phupong W, Intaraudom C, Sirawaraporn W, Kamchonwongpaisan S, Vanichtanankul J, Thebtaranonth Y, Yuthavong Y. Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum. Journal of Medicinal Chemistry. 45: 1244-52. PMID 11881993 DOI: 10.1021/Jm010131Q |
0.445 |
|
| 2002 |
Yuthavong Y. Basis for antifolate action and resistance in malaria. Microbes and Infection. 4: 175-82. PMID 11880049 DOI: 10.1016/S1286-4579(01)01525-8 |
0.475 |
|
| 2002 |
Chusacultanachai S, Thiensathit P, Tarnchompoo B, Sirawaraporn W, Yuthavong Y. Novel antifolate resistant mutations of Plasmodium falciparum dihydrofolate reductase selected in Escherichia coli. Molecular and Biochemical Parasitology. 120: 61-72. PMID 11849706 DOI: 10.1016/S0166-6851(01)00440-6 |
0.435 |
|
| 2002 |
Leartsakulpanich U, Imwong M, Pukrittayakamee S, White NJ, Snounou G, Sirawaraporn W, Yuthavong Y. Molecular characterization of dihydrofolate reductase in relation to antifolate resistance in Plasmodium vivax. Molecular and Biochemical Parasitology. 119: 63-73. PMID 11755187 DOI: 10.1016/S0166-6851(01)00402-9 |
0.46 |
|
| 2002 |
Ekthawatchai S, Kamchonwongpaisan S, Kongsaeree P, Tarnchompoo B, Thebtaranonth Y, Yuthavong Y. C-16 artemisinin derivatives and their antimalarial and cytotoxic activities: syntheses of artemisinin monomers, dimers, trimers, and tetramers by nucleophilic additions to artemisitene. Journal of Medicinal Chemistry. 44: 4688-95. PMID 11741486 DOI: 10.1021/Jm0103007 |
0.303 |
|
| 2001 |
Olliaro PL, Haynes RK, Meunier B, Yuthavong Y. Possible modes of action of the artemisinin-type compounds. Trends in Parasitology. 17: 122-6. PMID 11286794 DOI: 10.1016/S1471-4922(00)01838-9 |
0.368 |
|
| 2000 |
Yuthavong Y, Vilaivan T, Chareonsethakul N, Kamchonwongpaisan S, Sirawaraporn W, Quarrell R, Lowe G. Development of a lead inhibitor for the A16V+S108T mutant of dihydrofolate reductase from the cycloguanil-resistant strain (T9/94) of Plasmodium falciparum. Journal of Medicinal Chemistry. 43: 2738-44. PMID 10893311 DOI: 10.1021/Jm0009181 |
0.696 |
|
| 2000 |
Rastelli G, Sirawaraporn W, Sompornpisut P, Vilaivan T, Kamchonwongpaisan S, Quarrell R, Lowe G, Thebtaranonth Y, Yuthavong Y. Interaction of pyrimethamine, cycloguanil, WR99210 and their analogues with Plasmodium falciparum dihydrofolate reductase: structural basis of antifolate resistance. Bioorganic & Medicinal Chemistry. 8: 1117-28. PMID 10882022 DOI: 10.1016/S0968-0896(00)00022-5 |
0.679 |
|
| 2000 |
Charoenteeraboon J, Kamchonwongpaisan S, Wilairat P, Vattanaviboon P, Yuthavong Y. Inactivation of artemisinin by thalassemic erythrocytes. Biochemical Pharmacology. 59: 1337-44. PMID 10751542 DOI: 10.1016/S0006-2952(00)00271-9 |
0.399 |
|
| 1999 |
Olliaro PL, Yuthavong Y. An overview of chemotherapeutic targets for antimalarial drug discovery. Pharmacology & Therapeutics. 81: 91-110. PMID 10190581 DOI: 10.1016/S0163-7258(98)00036-9 |
0.386 |
|
| 1998 |
McKie JH, Douglas KT, Chan C, Roser SA, Yates R, Read M, Hyde JE, Dascombe MJ, Yuthavong Y, Sirawaraporn W. Rational drug design approach for overcoming drug resistance: application to pyrimethamine resistance in malaria. Journal of Medicinal Chemistry. 41: 1367-70. PMID 9554869 DOI: 10.1021/Jm970845U |
0.462 |
|
| 1998 |
Vattanaviboon P, Wilairat P, Yuthavong Y. Binding of dihydroartemisinin to hemoglobin H: role in drug accumulation and host-induced antimalarial ineffectiveness of alpha-thalassemic erythrocytes. Molecular Pharmacology. 53: 492-6. PMID 9495816 DOI: 10.1124/Mol.53.3.492 |
0.354 |
|
| 1997 |
Sirawaraporn W, Yongkiettrakul S, Sirawaraporn R, Yuthavong Y, Santi DV. Plasmodium falciparum: asparagine mutant at residue 108 of dihydrofolate reductase is an optimal antifolate-resistant single mutant. Experimental Parasitology. 87: 245-52. PMID 9371090 DOI: 10.1006/Expr.1997.4221 |
0.44 |
|
| 1997 |
Paitayatat S, Tarnchompoo B, Thebtaranonth Y, Yuthavong Y. Correlation of antimalarial activity of artemisinin derivatives with binding affinity with ferroprotoporphyrin IX. Journal of Medicinal Chemistry. 40: 633-8. PMID 9057849 DOI: 10.1021/Jm960767V |
0.368 |
|
| 1997 |
Sirawaraporn W, Sathitkul T, Sirawaraporn R, Yuthavong Y, Santi DV. Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase. Proceedings of the National Academy of Sciences of the United States of America. 94: 1124-9. PMID 9037017 DOI: 10.1073/Pnas.94.4.1124 |
0.418 |
|
| 1997 |
Prapunwattana P, Sirawaraporn W, Yuthavong Y, Santi DV. Chemical synthesis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene. Molecular and Biochemical Parasitology. 83: 93-106. PMID 9010845 DOI: 10.1016/S0166-6851(96)02756-9 |
0.378 |
|
| 1994 |
Kamchonwongpaisan S, Chandra-ngam G, Avery MA, Yuthavong Y. Resistance to artemisinin of malaria parasites (Plasmodium falciparum) infecting alpha-thalassemic erythrocytes in vitro. Competition in drug accumulation with uninfected erythrocytes. The Journal of Clinical Investigation. 93: 467-73. PMID 8113385 DOI: 10.1172/Jci116994 |
0.379 |
|
| 1993 |
Asawamahasakda W, Yuthavong Y. The methionine synthesis cycle and salvage of methyltetrahydrofolate from host red cells in the malaria parasite (Plasmodium falciparum). Parasitology. 1-10. PMID 8355992 DOI: 10.1017/S0031182000079348 |
0.399 |
|
| 1992 |
Ittarat I, Webster HK, Yuthavong Y. High-performance liquid chromatographic determination of dihydroorotate dehydrogenase of Plasmodium falciparum and effects of antimalarials on enzyme activity. Journal of Chromatography. 582: 57-64. PMID 1491058 DOI: 10.1016/0378-4347(92)80302-7 |
0.422 |
|
| 1992 |
Pookanjanatavip M, Yuthavong Y, Greene PJ, Santi DV. Subunit complementation of thymidylate synthase. Biochemistry. 31: 10303-9. PMID 1420149 DOI: 10.1021/Bi00157A018 |
0.401 |
|
| 1991 |
Sirawaraporn W, Sirawaraporn R, Cowman AF, Yuthavong Y, Santi DV. Heterologous expression of active thymidylate synthase-dihydrofolate reductase from Plasmodium falciparum. Biochemistry. 29: 10779-85. PMID 2176883 DOI: 10.1021/Bi00500A009 |
0.418 |
|
| 1990 |
Kamchonwongpaisan S, Bunyaratvej A, Wanachiwanawin W, Yuthavong Y. Susceptibility to hydrogen peroxide of Plasmodium falciparum infecting glucose-6-phosphate dehydrogenase-deficient erythrocytes. Parasitology. 171-4. PMID 2687776 DOI: 10.1017/S0031182000058601 |
0.315 |
|
| 1989 |
Krungkrai J, Webster HK, Yuthavong Y. Characterization of cobalamin-dependent methionine synthase purified from the human malarial parasite, Plasmodium falciparum. Parasitology Research. 75: 512-7. PMID 2671982 DOI: 10.1007/Bf00931158 |
0.411 |
|
| 1989 |
Krungkrai J, Yuthavong Y, Webster HK. High-performance liquid chromatographic assay for thymidylate synthase from the human malaria parasite, Plasmodium falciparum. Journal of Chromatography. 487: 51-9. PMID 2654157 DOI: 10.1016/S0378-4347(00)83006-6 |
0.32 |
|
| 1989 |
Kiatfuengfoo R, Suthiphongchai T, Prapunwattana P, Yuthavong Y. Mitochondria as the site of action of tetracycline on Plasmodium falciparum. Molecular and Biochemical Parasitology. 34: 109-15. PMID 2651921 DOI: 10.1016/0166-6851(89)90002-9 |
0.338 |
|
| 1989 |
Yuthavong Y, Butthep P, Bunyaratvej A, Fucharoen S. Decreased sensitivity of artesunate and chloroquine of Plasmodium falciparum infecting hemoglobin H and/or hemoglobin constant spring erythrocytes. The Journal of Clinical Investigation. 83: 502-5. PMID 2643631 DOI: 10.1172/Jci113910 |
0.381 |
|
| 1989 |
Krungkrai J, Webster HK, Yuthavong Y. De novo and salvage biosynthesis of pteroylpentaglutamates in the human malaria parasite, Plasmodium falciparum. Molecular and Biochemical Parasitology. 32: 25-37. PMID 2643036 DOI: 10.1016/0166-6851(89)90126-6 |
0.368 |
|
| 1988 |
Yuthavong Y, Butthep P, Bunyaratvej A, Fucharoen S, Khusmith S. Impaired parasite growth and increased susceptibility to phagocytosis of Plasmodium falciparum infected alpha-thalassemia or hemoglobin Constant Spring red blood cells. American Journal of Clinical Pathology. 89: 521-5. PMID 3281435 DOI: 10.1093/Ajcp/89.4.521 |
0.323 |
|
| 1988 |
Prapunwattana P, O'Sullivan WJ, Yuthavong Y. Depression of Plasmodium falciparum dihydroorotate dehydrogenase activity in in vitro culture by tetracycline Molecular and Biochemical Parasitology. 27: 119-124. PMID 2830511 DOI: 10.1016/0166-6851(88)90031-X |
0.373 |
|
| 1987 |
Krungkrai J, Yuthavong Y, Webster HK. High-performance liquid chromatographic assay for pteroylpolyglutamate hydrolase. Journal of Chromatography. 417: 47-56. PMID 3305536 DOI: 10.1016/0378-4347(87)80090-7 |
0.312 |
|
| 1987 |
Bunyaratvej A, Butthep P, Yuthavong Y, Fucharoen S, Khusmith S, Yoksan S, Wasi P. Increased phagocytosis of Plasmodium falciparum-infected erythrocytes with haemoglobin E by peripheral blood monocytes. Acta Haematologica. 76: 155-8. PMID 3101355 DOI: 10.1159/000206041 |
0.316 |
|
| 1986 |
Sirawaraporn W, Yuthavong Y. Potentiating effect of pyrimethamine and sulfadoxine against dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant Plasmodium chabaudi. Antimicrobial Agents and Chemotherapy. 29: 899-905. PMID 3729346 DOI: 10.1128/Aac.29.5.899 |
0.449 |
|
| 1985 |
Krungkrai J, Yuthavong Y, Webster HK. Guanosine triphosphate cyclohydrolase in Plasmodium falciparum and other Plasmodium species. Molecular and Biochemical Parasitology. 17: 265-76. PMID 3908934 DOI: 10.1016/0166-6851(85)90001-5 |
0.444 |
|
| 1984 |
Sirawaraporn W, Yuthavong Y. Kinetic and molecular properties of dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant Plasmodium chabaudi. Molecular and Biochemical Parasitology. 10: 355-67. PMID 6727925 DOI: 10.1016/0166-6851(84)90033-1 |
0.468 |
|
| 1983 |
Tungpradabkul S, Panyim S, Wilairat P, Yuthavong Y. Analysis of DNA from various species and strains of malaria parasites by restriction endonuclease fingerprinting. Comparative Biochemistry and Physiology. B, Comparative Biochemistry. 74: 481-5. PMID 6301750 DOI: 10.1016/0305-0491(83)90214-6 |
0.344 |
|
| 1982 |
Sirawaraporn W, Panijpan B, Yuthavong Y. Plasmodium berghei: uptake and distribution of chloroquine in infected mouse erythrocytes. Experimental Parasitology. 54: 260-70. PMID 6751843 DOI: 10.1016/0014-4894(82)90135-7 |
0.391 |
|
| 1982 |
Suthipark U, Krungkrai J, Jearnpipatkul A, Yuthavong Y, Panijpan B. Superoxide Dismutase (SOD) in Mouse Red Blood Cells Infected with Plasmodium berghei The Journal of Parasitology. 68: 337. DOI: 10.2307/3281204 |
0.306 |
|
| 1980 |
Jearnpipatkul A, Govitrapong P, Yuthavong Y, Wilairat P, Panijpan B. Binding of antimalarial drugs to hemozoin from Plasmodium berghei. Experientia. 36: 1063-4. PMID 6998717 DOI: 10.1007/Bf01965970 |
0.368 |
|
| 1980 |
Nakornchai S, Satarug S, Potiwan C, Yuthavong Y. Enhanced fusion capacity of malaria (Plasmodium berghei)-infected mouse red cells. Cell Biology International Reports. 4: 933-40. PMID 6998573 DOI: 10.1016/0309-1651(80)90195-2 |
0.304 |
|
| 1980 |
Yuthavong Y. Distribution of chloroquine in normal, pronase-treated and malaria-infected red cells. Life Sciences. 26: 1899-903. PMID 6995763 DOI: 10.1016/0024-3205(80)90619-0 |
0.32 |
|
| 1979 |
Siriwittayakorn J, Yuthavong Y. Relation between low erythrocyte acetylcholinesterase activity and membrane lipids in paroxysmal nocturnal haemoglobinuria. British Journal of Haematology. 41: 383-91. PMID 427042 DOI: 10.1111/J.1365-2141.1979.Tb05871.X |
0.342 |
|
| 1972 |
Lowe G, Yuthavong Y. pH-dependence and structure-activity relationships in the papain-catalysed hydrolysis of anilides. The Biochemical Journal. 124: 117-22. PMID 5126467 DOI: 10.1042/Bj1240117 |
0.487 |
|
| 1972 |
Lowe G, Yuthavong Y. Kinetic specificity in papain-catalysed hydrolyses. The Biochemical Journal. 124: 107-15. PMID 5126466 DOI: 10.1042/Bj1240107 |
0.535 |
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