| Year |
Citation |
Score |
| 2023 |
He HJ, Wang RQ, Wan LX, Zhou LY, Li HY, Li GB, Xiao YC, Chen FE. Organocatalytic Asymmetric Morita-Baylis-Hillman Reaction of Isatins with Vinyl Sulfones. The Journal of Organic Chemistry. 88: 3802-3807. PMID 36822154 DOI: 10.1021/acs.joc.2c03073 |
0.312 |
|
| 2023 |
Hao QQ, Chen XM, Pannecouque C, De Clercq E, Wang S, Chen FE. Structure-directed linker optimization of novel HEPTs as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorganic Chemistry. 133: 106413. PMID 36791619 DOI: 10.1016/j.bioorg.2023.106413 |
0.304 |
|
| 2022 |
Zhou RL, Ju Z, Pannecouque C, Clercq E, Wang S, Chen FE. Structure-guided design of novel HEPT analogs with enhanced potency and safety: From Isopropyl-HEPTs to Cyclopropyl-HEPTs. European Journal of Medicinal Chemistry. 246: 114939. PMID 36442370 DOI: 10.1016/j.ejmech.2022.114939 |
0.311 |
|
| 2022 |
Zhou Y, Xiong T, Zhou LY, Li HY, Xiao YC, Chen FE. Diastereo- and Enantioselective Synthesis of Borylated 3-Hydroxyoxindoles by Addition of -Diborylalkanes to Isatins. Organic Letters. 24: 791-796. PMID 35005977 DOI: 10.1021/acs.orglett.1c04380 |
0.335 |
|
| 2021 |
Ding L, Pannecouque C, De Clercq E, Zhuang C, Chen FE. Improving Druggability of Novel Diarylpyrimidine NNRTIs by a Fragment-Based Replacement Strategy: From Biphenyl-DAPYs to Heteroaromatic-Biphenyl-DAPYs. Journal of Medicinal Chemistry. PMID 34197708 DOI: 10.1021/acs.jmedchem.1c00708 |
0.306 |
|
| 2021 |
Ding L, Pannecouque C, De Clercq E, Zhuang C, Chen FE. Hydrophobic Pocket Occupation Design of Difluoro-Biphenyl-Diarylpyrimidines as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: from -Alkylation to Methyl Hopping on the Pyrimidine Ring. Journal of Medicinal Chemistry. 64: 5067-5081. PMID 33851529 DOI: 10.1021/acs.jmedchem.1c00128 |
0.306 |
|
| 2020 |
Chen X, Ding L, Tao Y, Pannecouque C, De Clercq E, Zhuang C, Chen FE. Bioisosterism-based design and enantiomeric profiling of chiral hydroxyl-substituted biphenyl-diarylpyrimidine nonnucleoside HIV-1 reverse transcriptase inhibitors. European Journal of Medicinal Chemistry. 202: 112549. PMID 32712537 DOI: 10.1016/J.Ejmech.2020.112549 |
0.43 |
|
| 2020 |
Zhuang C, Pannecouque C, De Clercq E, Chen F. Development of non-nucleoside reverse transcriptase inhibitors (NNRTIs): our past twenty years. Acta Pharmaceutica Sinica. B. 10: 961-978. PMID 32642405 DOI: 10.1016/J.Apsb.2019.11.010 |
0.388 |
|
| 2020 |
Chen F, Zhang W, Chen X, An Y, Wang J, Zhuang C, Tang P. Enantioselective Total Syntheses of (-)-20-epi-Vincamine and (-)-20-epi-Eburnamonine via Ir-Catalyzed Asymmetric Imine Hydrogenation/Lactamization Cascade. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 32500532 DOI: 10.1002/Chem.202002404 |
0.441 |
|
| 2020 |
Wang Y, Huang G, Shi Y, Tian WS, Zhuang C, Chen FE. Correction: Asymmetric synthesis of (-)-solanidine and (-)-tomatidenol. Organic & Biomolecular Chemistry. PMID 32441732 DOI: 10.1039/D0Ob90067B |
0.304 |
|
| 2020 |
Ke M, Liu Z, Huang G, Wang J, Tao Y, Chen F. Palladium-Catalyzed Regio- and Stereoselective Cross-Coupling of Vinylethylene Carbonates with Ketimine Esters to Generate ()-Tri- and Tetra-substituted Allylic Amino Acid Derivatives. Organic Letters. PMID 32383610 DOI: 10.1021/Acs.Orglett.0C01211 |
0.394 |
|
| 2020 |
Yang Y, Pannecouque C, Clercq E, Zhuang C, Chen FE. Privileged scaffold inspired design of novel oxime-biphenyl-DAPYs in treatment of HIV-1. Bioorganic Chemistry. 99: 103825. PMID 32334191 DOI: 10.1016/J.Bioorg.2020.103825 |
0.389 |
|
| 2020 |
Wang Y, Huang G, Shi Y, Tian WS, Zhuang C, Chen FE. Asymmetric synthesis of (-)-solanidine and (-)-tomatidenol. Organic & Biomolecular Chemistry. PMID 32270168 DOI: 10.1039/D0Ob00457J |
0.409 |
|
| 2020 |
Li TT, Pannecouque C, De Clercq E, Zhuang CL, Chen FE. Scaffold Hopping in Discovery of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: From CH(CN)-DABOs to CH(CN)-DAPYs. Molecules (Basel, Switzerland). 25. PMID 32235557 DOI: 10.3390/Molecules25071581 |
0.362 |
|
| 2020 |
Huang G, Ke M, Tao Y, Chen F. Specific Z-Selectivity in the Oxidative Isomerization of Allyl Ethers to Generate Geometrically Defined Z-Enol Ethers using a Cobalt(II)(salen) Complex Catalyst. The Journal of Organic Chemistry. PMID 32208604 DOI: 10.1021/Acs.Joc.0C00004 |
0.357 |
|
| 2020 |
Wu X, Huang Z, Wang Z, Li Z, Wang J, Lin J, Chen F. Asymmetric Synthesis of a Key Dextromethorphan Intermediate and Its Analogs Enabled by a New Cyclohexylamine Oxidase: Enzyme Discovery, Reaction Development, and Mechanistic Insight. The Journal of Organic Chemistry. PMID 32203655 DOI: 10.1021/Acs.Joc.0C00469 |
0.366 |
|
| 2020 |
Wang Z, Zeng Y, Wu X, Li Z, Tao Y, Yu X, Huang Z, Chen F. Access to chiral α-substituted-β-hydroxy arylphosphonates enabled by biocatalytic dynamic reductive kinetic resolution. Organic & Biomolecular Chemistry. PMID 32202289 DOI: 10.1039/D0Ob00379D |
0.336 |
|
| 2020 |
Wang Y, Shi Y, Tian WS, Tang P, Zhuang C, Chen FE. Stereoselective Synthesis of (-)-Verazine and Congeners via a Cascade Ring-Switching Process of Furostan-26-acid. Organic Letters. PMID 32202118 DOI: 10.1021/Acs.Orglett.0C00747 |
0.42 |
|
| 2020 |
Lei Y, Han S, Yang Y, Pannecouque C, De Clercq E, Zhuang C, Chen FE. Design of Biphenyl-Substituted Diarylpyrimidines with a Cyanomethyl Linker as HIV-1 NNRTIs via a Molecular Hybridization Strategy. Molecules (Basel, Switzerland). 25. PMID 32111013 DOI: 10.3390/Molecules25051050 |
0.399 |
|
| 2020 |
Jin K, Liu M, Zhuang C, De Clercq E, Pannecouque C, Meng G, Chen F. Improving the positional adaptability: structure-based design of biphenyl-substituted diaryltriazines as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. Acta Pharmaceutica Sinica. B. 10: 344-357. PMID 32082978 DOI: 10.1016/J.Apsb.2019.09.007 |
0.418 |
|
| 2020 |
Sang Y, Pannecouque C, De Clercq E, Zhuang C, Chen F. Pharmacophore-fusing design of pyrimidine sulfonylacetanilides as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorganic Chemistry. 96: 103595. PMID 32006797 DOI: 10.1016/J.Bioorg.2020.103595 |
0.356 |
|
| 2020 |
Luo L, Li H, Liu J, Zhou Y, Dong L, Xiao Y, Chen F. Transition-metal and oxidant-free approach for the synthesis of diverse N-heterocycles by TMSCl activation of isocyanides Rsc Advances. 10: 29257-29262. DOI: 10.1039/D0Ra04636A |
0.326 |
|
| 2020 |
Dong L, Chen F. Asymmetric catalysis in direct nitromethane-free Henry reactions Rsc Advances. 10: 2313-2326. DOI: 10.1039/C9Ra10263A |
0.375 |
|
| 2020 |
Hu C, Liu M, Yue X, Huang Z, Chen F. Development of a Practical, Biocatalytic Synthesis of tert-Butyl (R)-3-Hydroxyl-5-hexenoate: A Key Intermediate to the Statin Side Chain Organic Process Research & Development. DOI: 10.1021/Acs.Oprd.0C00320 |
0.313 |
|
| 2020 |
Hu S, Lu Z, Liu M, Xu H, Wu J, Chen F. TfOH-Catalyzed Cascade C-H Activation/Lactonization of Phenols with alpha-Aryl-alpha-Diazoesters: Rapid Access to alpha-Aryl Benzofuranones. Journal of Organic Chemistry. DOI: 10.1021/Acs.Joc.0C01583 |
0.305 |
|
| 2020 |
Han S, Lei Y, Pannecouque C, Clercq ED, Zhuang C, Chen F. Fragment-based discovery of sulfur-containing diarylbenzopyrimidines as novel nonnucleoside reverse transcriptase inhibitors Chinese Chemical Letters. 31: 764-768. DOI: 10.1016/J.Cclet.2019.11.020 |
0.374 |
|
| 2020 |
Li Y, Liu J, Chen X, Zhou Y, Xiao Y, Chen F. Asymmetric Alkynylation of Cyclic N‐Sulfonyl Imines using Synergistic Chiral Phosphoric Acid/Copper Catalysis Advanced Synthesis & Catalysis. 362: 3202-3207. DOI: 10.1002/Adsc.202000504 |
0.342 |
|
| 2019 |
Hu S, Wang J, Huang G, Zhu K, Chen F. Organocatalytic Asymmetric Domino oxa-Michael-Mannich-[1,3]-Amino Rearrangement Reaction of N-Tosylsalicylimines to α,β-Unsaturated Aldehydes by Diarylprolinol Silyl Ethers. The Journal of Organic Chemistry. PMID 31829579 DOI: 10.1021/Acs.Joc.9B02939 |
0.377 |
|
| 2019 |
Xiao T, Tang JF, Meng G, Pannecouque C, Zhu YY, Liu GY, Xu ZQ, Wu FS, Gu SX, Chen FE. Indazolyl-substituted piperidin-4-yl-aminopyrimidines as HIV-1 NNRTIs: Design, synthesis and biological activities. European Journal of Medicinal Chemistry. 111864. PMID 31767136 DOI: 10.1016/J.Ejmech.2019.111864 |
0.414 |
|
| 2019 |
Han S, Sang Y, Wu Y, Tao Y, Pannecouque C, De Clercq E, Zhuang C, Chen FE. Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors. European Journal of Medicinal Chemistry. 111874. PMID 31735575 DOI: 10.1016/J.Ejmech.2019.111874 |
0.398 |
|
| 2019 |
Han S, Sang Y, Wu Y, Tao Y, Pannecouque C, De Clercq E, Zhuang C, Chen F. Molecular Hybridization-Inspired Optimization of Diarylbenzopyrimidines as HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors with Improved Activity against K103N, E138K Mutants, and Pharmacokinetic Profiles. Acs Infectious Diseases. PMID 31599568 DOI: 10.1021/Acsinfecdis.9B00229 |
0.375 |
|
| 2019 |
Sang Y, Han S, Pannecouque C, De Clercq E, Zhuang C, Chen F. Conformational restriction design of thiophene-biphenyl-DAPY HIV-1 non-nucleoside reverse transcriptase inhibitors. European Journal of Medicinal Chemistry. 182: 111603. PMID 31421633 DOI: 10.1016/J.Ejmech.2019.111603 |
0.4 |
|
| 2019 |
Sang Y, Han S, Han S, Pannecouque C, De Clercq E, Zhuang C, Chen F. Follow on-based optimization of the biphenyl-DAPYs as HIV-1 nonnucleoside reverse transcriptase inhibitors against the wild-type and mutant strains. Bioorganic Chemistry. 89: 102974. PMID 31102693 DOI: 10.1016/J.Bioorg.2019.102974 |
0.413 |
|
| 2019 |
Jin K, Sang Y, Han S, De Clercq E, Pannecouque C, Meng G, Chen F. Synthesis and biological evaluation of dihydroquinazoline-2-amines as potent non-nucleoside reverse transcriptase inhibitors of wild-type and mutant HIV-1 strains. European Journal of Medicinal Chemistry. 176: 11-20. PMID 31091477 DOI: 10.1016/J.Ejmech.2019.05.011 |
0.4 |
|
| 2019 |
Gu SX, Xiao T, Zhu YY, Liu GY, Chen FE. Recent progress in HIV-1 inhibitors targeting the entrance channel of HIV-1 non-nucleoside reverse transcriptase inhibitor binding pocket. European Journal of Medicinal Chemistry. 174: 277-291. PMID 31051402 DOI: 10.1016/J.Ejmech.2019.04.054 |
0.353 |
|
| 2019 |
Zhu K, Hu S, Liu M, Peng H, Chen F. Collective Total Synthesis of the Prostaglandins Family via Stereocontrolled Organocatalytic Baeyer-Villiger Oxidation. Angewandte Chemie (International Ed. in English). PMID 30983061 DOI: 10.1002/Ange.201902371 |
0.367 |
|
| 2019 |
Wang Z, Wu X, Li Z, Huang Z, Chen F. Ketoreductase catalyzed stereoselective bioreduction of α-nitro ketones. Organic & Biomolecular Chemistry. PMID 30900703 DOI: 10.1039/C9Ob00051H |
0.36 |
|
| 2019 |
Liu Q, Huang G, Liu M, Chen F. A Concise Total Synthesis of (±)-Camptothecin Synthesis. 51: 3506-3510. DOI: 10.1055/S-0037-1611870 |
0.405 |
|
| 2019 |
Liu Q, Liu M, Huang G, Chen F. Asymmetric total synthesis of (20S)-Camptothecin using a chiral auxiliary strategy Tetrahedron. 75: 2647-2651. DOI: 10.1016/J.Tet.2019.03.028 |
0.459 |
|
| 2019 |
Liu Q, Huang G, Liu M, Chen F. Cover Feature: A Formal Synthesis of Camptothecin via a Photocatalytic Decarboxylative Radical Addition (Eur. J. Org. Chem. 35/2019) European Journal of Organic Chemistry. 2019: 6004-6004. DOI: 10.1002/Ejoc.201901237 |
0.332 |
|
| 2019 |
Liu Q, Huang G, Liu M, Chen F. A Formal Synthesis of Camptothecin via a Photocatalytic Decarboxylative Radical Addition European Journal of Organic Chemistry. 2019: 6024-6027. DOI: 10.1002/Ejoc.201900728 |
0.355 |
|
| 2019 |
Ke M, Huang G, Ding L, Fang J, Chen F. Direct Synthesis of Substituted (
Z
)‐Allylic Sulfones by Palladium‐Catalyzed Sulfonylation of Vinylethylene Carbonates with Sodium Sulfinates Chemcatchem. 11: 4720-4724. DOI: 10.1002/Cctc.201901292 |
0.351 |
|
| 2019 |
Xiao Y, Chen F. Cover Feature: Chloramphenicol Base: A New Privileged Chiral Scaffold in Asymmetric Catalysis (ChemCatChem 8/2019) Chemcatchem. 11: 2018-2018. DOI: 10.1002/Cctc.201900586 |
0.326 |
|
| 2019 |
Xiao Y, Chen F. Chloramphenicol Base: A New Privileged Chiral Scaffold in Asymmetric Catalysis Chemcatchem. 11: 2043-2053. DOI: 10.1002/Cctc.201900150 |
0.345 |
|
| 2019 |
Li Z, Wang Z, Wang Y, Wu X, Lu H, Huang Z, Chen F. Substituent Position‐Controlled Stereoselectivity in Enzymatic Reduction of Diaryl‐ and Aryl(heteroaryl)methanones Advanced Synthesis & Catalysis. 361: 1859-1865. DOI: 10.1002/Adsc.201801543 |
0.409 |
|
| 2018 |
Huang G, Liu M, Xiong F, Meng G, Tao Y, Wu Y, Peng H, Chen F. Chiral Syn-1,3-diol Derivatives via a One-Pot Diastereoselective Carboxylation/ Bromocyclization of Homoallylic Alcohols. Iscience. 9: 513-520. PMID 30476789 DOI: 10.1016/J.Isci.2018.11.010 |
0.406 |
|
| 2018 |
Xu L, Han S, Yan L, Wang H, Peng H, Chen F. Novel amide-functionalized chloramphenicol base bifunctional organocatalysts for enantioselective alcoholysis of-cyclic anhydrides. Beilstein Journal of Organic Chemistry. 14: 309-317. PMID 29507636 DOI: 10.3762/Bjoc.14.19 |
0.373 |
|
| 2018 |
Jin K, Yin H, De Clercq E, Pannecouque C, Meng G, Chen F. Discovery of biphenyl-substituted diarylpyrimidines as non-nucleoside reverse transcriptase inhibitors with high potency against wild-type and mutant HIV-1. European Journal of Medicinal Chemistry. 145: 726-734. PMID 29353724 DOI: 10.1016/J.Ejmech.2018.01.016 |
0.409 |
|
| 2018 |
Yan L, Huang G, Wang H, Xiong F, Peng H, Chen F. Squaramide‐Linked Chloramphenicol Base Hybrid Catalysts for the Asymmetric Michael Addition of 2,3‐Dihydrobenzofuran‐2‐carboxylates to Nitroolefins European Journal of Organic Chemistry. 2018: 99-103. DOI: 10.1002/Ejoc.201701485 |
0.33 |
|
| 2018 |
Li Z, Wang Z, Meng G, Lu H, Huang Z, Chen F. Front Cover: Identification of an Ene Reductase from Yeast Kluyveromyces Marxianus and Application in the Asymmetric Synthesis of (R)‐Profen Esters (Asian J. Org. Chem. 4/2018) Asian Journal of Organic Chemistry. 7: 598-598. DOI: 10.1002/Ajoc.201800188 |
0.352 |
|
| 2018 |
Li Z, Wang Z, Meng G, Lu H, Huang Z, Chen F. Identification of an Ene Reductase from Yeast Kluyveromyces Marxianus and Application in the Asymmetric Synthesis of (R)‐Profen Esters Asian Journal of Organic Chemistry. 7: 763-769. DOI: 10.1002/Ajoc.201800059 |
0.36 |
|
| 2018 |
Chen L, Huang G, Liu M, Huang Z, Chen F. Development of Novel Chloramphenicol Scaffold‐Based Chiral Hydroxyl Oxazoline Ligands and Their Application to the Asymmetric Alkynylation of Isatins Advanced Synthesis & Catalysis. 360: 3497-3501. DOI: 10.1002/Adsc.201800581 |
0.328 |
|
| 2017 |
Peng H, Chen FE. Recent advances in asymmetric total synthesis of prostaglandins. Organic & Biomolecular Chemistry. PMID 28737187 DOI: 10.1039/C7Ob01341H |
0.369 |
|
| 2017 |
Chen L, Chen F. Total Synthesis of Camptothecins: An Update Synlett. 28: 1134-1150. DOI: 10.1055/S-0036-1588738 |
0.453 |
|
| 2017 |
Yan L, Wang H, Xiong F, Tao Y, Wu Y, Chen F. Chloramphenicol base chemistry. Part 11:1 chloramphenicol base-derived thiourea-catalyzed enantioselective Michael addition of malononitrile to α,β-unsaturated ketones Tetrahedron-Asymmetry. 28: 921-929. DOI: 10.1016/J.Tetasy.2017.05.015 |
0.37 |
|
| 2017 |
Wang X, Xu L, Xiong F, Wu Y, Chen F. An improved synthesis of (20S)-camptothecin and its analogue via an asymmetric α-hydroxylation with a chiral organocatalyst Tetrahedron-Asymmetry. 28: 843-848. DOI: 10.1016/J.Tetasy.2017.04.013 |
0.447 |
|
| 2017 |
Wang Y, Huang G, Hu S, Jin K, Wu Y, Chen F. Enantioselective β-hydroxy thioesters formation via decarboxylative aldol reactions of malonic acid half thioesters with aldehydes promoted by chloramphenicol derived sulfonamides 1 Tetrahedron. 73: 5055-5062. DOI: 10.1016/J.Tet.2017.05.066 |
0.428 |
|
| 2017 |
Wang H, Yan L, Wu Y, Chen F. Chloramphenicol base chemistry. Part 101: Asymmetric synthesis of α-hydroxy chiral alcohols via intramolecular Michael additions of γ-hydroxy-α, β-unsaturated enones with chloramphenicol base derived bifunctional urea organocatalysts Tetrahedron. 73: 2793-2800. DOI: 10.1016/J.Tet.2017.03.076 |
0.386 |
|
| 2017 |
Wu Y, Liu M, Huang H, Huang G, Xiong F, Chen F. Asymmetric Synthesis of Atorvastatin Calcium through Intramolecular Oxidative Oxygen‐Nucleophilic Bromocyclization European Journal of Organic Chemistry. 2017: 3681-3688. DOI: 10.1002/Ejoc.201700387 |
0.399 |
|
| 2016 |
Mao TQ, He QQ, Chen WX, Tang GF, Chen FE, De Clercq E, Daelemans D, Pannecouque C. Structural Modifications of Diarylpyrimidine-quinolone Hybrids as Potent HIV-1 NNRTIs with an Improved Drug Resistance Profile. Current Pharmaceutical Design. PMID 27875973 DOI: 10.2174/1381612823666161122125657 |
0.394 |
|
| 2016 |
Wang H, Yan L, Xiong F, Wu Y, Chen F. New chloramphenicol Schiff base ligands for the titanium-mediated asymmetric aldol reaction of α,β-unsaturated aldehydes with diketene: a short synthesis of atorvastatin calcium Rsc Advances. 6: 75470-75477. DOI: 10.1039/C6Ra15304F |
0.376 |
|
| 2016 |
Wang X, Xu L, Xiong F, Wu Y, Chen F. A new cost-effective Ru-chloramphenicol base derivative catalyst for the asymmetric transfer hydrogenation/dynamic kinetic resolution of N-Boc α-amino-β-ketoesters and its application to the synthesis of the chiral core of vancomycin Rsc Advances. 6: 37701-37709. DOI: 10.1039/C6Ra05109J |
0.355 |
|
| 2016 |
Wang Y, Chen F, Shi Y, Tian W. Multigram scale, chiron-based synthesis of sacubitril Tetrahedron Letters. 57: 5928-5930. DOI: 10.1016/J.Tetlet.2016.11.078 |
0.395 |
|
| 2016 |
Wang X, Xu L, Yan L, Wang H, Han S, Wu Y, Chen F. Catalytic asymmetric transfer hydrogenation/dynamic kinetic resolution: An efficient synthesis of florfenicol Tetrahedron. 72. DOI: 10.1016/J.Tet.2016.02.045 |
0.437 |
|
| 2016 |
Xiong F, Li G, Song B, Chen FE, Zeng ZS. A novel synthetic route to 7-MAC from 7-ACA Journal of the Iranian Chemical Society. 13: 1019-1025. DOI: 10.1007/S13738-016-0815-0 |
0.411 |
|
| 2016 |
Yan LJ, Wang HF, Chen WX, Tao Y, Jin KJ, Chen FE. Development of Bifunctional Thiourea Organocatalysts Derived from a Chloramphenicol Base Scaffold and their Use in the Enantioselective Alcoholysis of meso Cyclic Anhydrides Chemcatchem. 8: 2249-2253. DOI: 10.1002/Cctc.201600228 |
0.306 |
|
| 2015 |
Xiong F, Wang H, Yan L, Han S, Tao Y, Wu Y, Chen F. Stereocontrolled synthesis of rosuvastatin calcium via iodine chloride-induced intramolecular cyclization. Organic & Biomolecular Chemistry. PMID 26659808 DOI: 10.1039/C5Ob02245B |
0.36 |
|
| 2015 |
Wang H, Yan L, Wu Y, Lu Y, Chen F. Asymmetric Synthesis of Vitamin D3 Analogues: Organocatalytic Desymmetrization Approach toward the A-Ring Precursor of Calcifediol. Organic Letters. PMID 26507192 DOI: 10.1021/Acs.Orglett.5B02813 |
0.428 |
|
| 2015 |
Wan ZY, Yao J, Mao TQ, Wang XL, Wang HF, Chen WX, Yin H, Chen FE, De Clercq E, Daelemans D, Pannecouque C. Pyrimidine sulfonylacetanilides with improved potency against key mutant viruses of HIV-1 by specific targeting of a highly conserved residue. European Journal of Medicinal Chemistry. 102: 215-222. PMID 26276435 DOI: 10.1016/J.Ejmech.2015.08.007 |
0.393 |
|
| 2015 |
Xiong F, Wang H, Yan L, Xu L, Tao Y, Wu Y, Chen F. Diastereoselective synthesis of pitavastatin calcium via bismuth-catalyzed two-component hemiacetal/oxa-Michael addition reaction. Organic & Biomolecular Chemistry. PMID 26275074 DOI: 10.1039/C5Ob01148E |
0.37 |
|
| 2015 |
Wan ZY, Tao Y, Wang YF, Mao TQ, Yin H, Chen FE, Piao HR, De Clercq E, Daelemans D, Pannecouque C. Hybrid chemistry. Part 4: Discovery of etravirine-VRX-480773 hybrids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors. Bioorganic & Medicinal Chemistry. 23: 4248-55. PMID 26162497 DOI: 10.1016/J.Bmc.2015.06.048 |
0.4 |
|
| 2015 |
Wan ZY, Yao J, Tao Y, Mao TQ, Wang XL, Lu YP, Wang HF, Yin H, Wu Y, Chen FE, De Clercq E, Daelemans D, Pannecouque C. Discovery of piperidin-4-yl-aminopyrimidine derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. European Journal of Medicinal Chemistry. 97: 1-9. PMID 25935383 DOI: 10.1016/J.Ejmech.2015.04.050 |
0.426 |
|
| 2015 |
Mao TQ, He QQ, Wan ZY, Chen WX, Chen FE, Tang GF, De Clercq E, Daelemans D, Pannecouque C. Anti-HIV diarylpyrimidine-quinolone hybrids and their mode of action. Bioorganic & Medicinal Chemistry. 23: 3860-8. PMID 25907370 DOI: 10.1016/J.Bmc.2015.03.037 |
0.379 |
|
| 2015 |
Wu HQ, Yao J, He QQ, Chen WX, Chen FE, Pannecouque C, De Clercq E, Daelemans D. Synthesis and biological evaluation of DAPY-DPEs hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorganic & Medicinal Chemistry. 23: 624-31. PMID 25537532 DOI: 10.1016/J.Bmc.2014.11.032 |
0.381 |
|
| 2015 |
Wu Y, Xiong F, Chen F. Stereoselective synthesis of 3-hydroxy-3-methylglutaryl–coenzyme A reductase inhibitors Tetrahedron. 71: 8487-8510. DOI: 10.1016/J.Tet.2015.07.059 |
0.41 |
|
| 2015 |
Chen W, Xiong F, Liu Q, Xu L, Wu Y, Chen F. Substrate stereocontrol in bromine-induced intermolecular cyclization: asymmetric synthesis of pitavastatin calcium Tetrahedron. 71: 4730-4737. DOI: 10.1016/J.Tet.2015.05.053 |
0.387 |
|
| 2015 |
Gu S, Zhu Y, Chen F, Clercq ED, Balzarini J, Pannecouque C. Structural modification of diarylpyrimidine derivatives as HIV-1 reverse transcriptase inhibitors Medicinal Chemistry Research. 24: 220-225. DOI: 10.1007/S00044-014-1119-5 |
0.398 |
|
| 2015 |
Zheng C, Chen W, Chen F. Asymmetric Amination of 3‐(2‐Oxoindolin‐3‐ylidene)butanoates Catalyzed by a Cinchona‐derived Alkaloid Asian Journal of Organic Chemistry. 4: 1044-1046. DOI: 10.1002/Ajoc.201500299 |
0.429 |
|
| 2015 |
Zheng C, Wang H, Chen W, Chen W, Chen F. Organocatalytic Asymmetric Vinylogous Michael Addition of 3‐(2‐Oxoindolin‐3‐ylidene)butanoates to Nitroalkenes Catalyzed by a Bifunctional Cinchona‐Based Squaramide Asian Journal of Organic Chemistry. 4: 619-621. DOI: 10.1002/Ajoc.201500111 |
0.402 |
|
| 2014 |
Wu HQ, Yao J, He QQ, Chen FE. Docking-based CoMFA and CoMSIA studies on naphthyl-substituted diarylpyrimidines as NNRTIs. Sar and Qsar in Environmental Research. 25: 761-75. PMID 25242254 DOI: 10.1080/1062936X.2014.955054 |
0.325 |
|
| 2014 |
Liu Y, Meng G, Zheng A, Chen F, Chen W, De Clercq E, Pannecouque C, Balzarini J. Design and synthesis of a new series of cyclopropylamino-linking diarylpyrimidines as HIV non-nucleoside reverse transcriptase inhibitors. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 62: 334-41. PMID 24956462 DOI: 10.1016/J.Ejps.2014.06.003 |
0.435 |
|
| 2014 |
Meng G, Liu Y, Zheng A, Chen F, Chen W, De Clercq E, Pannecouque C, Balzarini J. Design and synthesis of a new series of modified CH-diarylpyrimidines as drug-resistant HIV non-nucleoside reverse transcriptase inhibitors. European Journal of Medicinal Chemistry. 82: 600-11. PMID 24952305 DOI: 10.1016/J.Ejmech.2014.05.059 |
0.416 |
|
| 2014 |
Yan ZH, Wu HQ, Chen WX, Wu Y, Piao HR, He QQ, Chen FE, De Clercq E, Pannecouque C. Synthesis and biological evaluation of CHX-DAPYs as HIV-1 non-nucleoside reverse transcriptase inhibitors. Bioorganic & Medicinal Chemistry. 22: 3220-6. PMID 24794751 DOI: 10.1016/J.Bmc.2014.03.020 |
0.425 |
|
| 2014 |
Yan ZH, Huang XY, Wu HQ, Chen WX, He QQ, Chen FE, De Clercq E, Pannecouque C. Structural modifications of CH(OH)-DAPYs as new HIV-1 non-nucleoside reverse transcriptase inhibitors. Bioorganic & Medicinal Chemistry. 22: 2535-41. PMID 24680058 DOI: 10.1016/J.Bmc.2014.02.030 |
0.382 |
|
| 2014 |
Chen X, Xiong F, Chen W, He Q, Chen F. Asymmetric synthesis of the HMG-CoA reductase inhibitor atorvastatin calcium: an organocatalytic anhydride desymmetrization and cyanide-free side chain elongation approach. The Journal of Organic Chemistry. 79: 2723-8. PMID 24575888 DOI: 10.1021/Jo402829B |
0.348 |
|
| 2014 |
Chen F, Chen X. An Efficient Synthesis of Katsube Nitrile: A Key Building Block for Eburnamine-Vincamine Alkaloids Synthesis. 46: 1506-1510. DOI: 10.1055/S-0033-1340988 |
0.407 |
|
| 2014 |
Wu H, Pannecouque C, Yan Z, Chen W, He Q, Chen F, Balzarini J, Daelemans D, Clercq ED. Synthesis and biological evaluation of new conformationally restricted S-DABO hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase Medchemcomm. 5: 468-473. DOI: 10.1039/C3Md00247K |
0.419 |
|
| 2014 |
Xiong F, Li J, Chen X, Chen W, Chen F. An improved process for chiron synthesis of the atorvastatin side chain Tetrahedron: Asymmetry. 25: 1205-1208. DOI: 10.1016/J.Tetasy.2014.07.002 |
0.37 |
|
| 2014 |
Chen X, Xiong F, Zheng C, Li J, Chen F. Synthetic studies on statins. Part 3: A facile synthesis of rosuvastatin calcium through catalytic enantioselective allylation strategy Tetrahedron. 70: 5794-5799. DOI: 10.1016/J.Tet.2014.06.077 |
0.386 |
|
| 2014 |
Zheng C, Chen F. Asymmetric catalytic anhydride openings via carbon-based nucleophiles Chinese Chemical Letters. 25: 1-8. DOI: 10.1016/J.Cclet.2013.11.025 |
0.336 |
|
| 2013 |
Wu HQ, Yan ZH, Chen WX, He QQ, Chen FE, De Clercq E, Balzarini J, Daelemans D, Pannecouque C. Towards new C6-rigid S-DABO HIV-1 reverse transcriptase inhibitors: synthesis, biological investigation and molecular modeling studies. Bioorganic & Medicinal Chemistry. 21: 6477-83. PMID 24055077 DOI: 10.1016/J.Bmc.2013.08.040 |
0.427 |
|
| 2013 |
Yang S, Pannecouque C, Daelemans D, Ma XD, Liu Y, Chen FE, De Clercq E. Molecular design, synthesis and biological evaluation of BP-O-DAPY and O-DAPY derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors. European Journal of Medicinal Chemistry. 65: 134-43. PMID 23707918 DOI: 10.1016/J.Ejmech.2013.04.052 |
0.44 |
|
| 2013 |
Liu Q, Xiong F, He Q, Chen F. Development of an Efficient Process for the Decomposition of the Borate Complexes Formed during the Large-Scale Synthesis of (S)-1,2,4-Butanetriol Organic Process Research & Development. 17: 1540-1542. DOI: 10.1021/Op400271K |
0.301 |
|
| 2013 |
Hu L, Xiong F, Chen X, Chen W, He Q, Chen F. Synthetic studies on statins. Part 1: a short and cyanide-free synthesis of atorvastatin calcium via an enantioselective aldol strategy Tetrahedron: Asymmetry. 24: 207-211. DOI: 10.1016/J.Tetasy.2012.12.009 |
0.36 |
|
| 2013 |
Yang H, Xiong F, Li J, Chen F. A family of novel bifunctional organocatalysts: Highly enantioselective alcoholysis of meso cyclic anhydrides and its application for synthesis of the key intermediate of P2X7 receptor antagonists Chinese Chemical Letters. 24: 553-558. DOI: 10.1016/J.Cclet.2013.04.009 |
0.381 |
|
| 2013 |
Xiong F, Xiong FJ, Chen WX, Jia HQ, Chen FE. Highly enantioselective methanolysis of meso-cyclic anhydride mediated by bifunctional thiourea cinchona alkaloid derivatives: Access to asymmetric total synthesis of (+)-biotin Journal of Heterocyclic Chemistry. 50: 1078-1082. DOI: 10.1002/Jhet.1512 |
0.446 |
|
| 2013 |
Yang H, Xiong F, Chen X, Chen F. Highly Enantioselective Thiolysis of Prochiral Cyclic Anhydrides Catalyzed by Amino Alcohol Bifunctional Organocatalysts and Its Application to the Synthesis of Pregabalin European Journal of Organic Chemistry. 2013: 4495-4498. DOI: 10.1002/Ejoc.201300464 |
0.398 |
|
| 2012 |
Ma XD, He QQ, Zhang X, Yang SQ, Yang LM, Gu SX, Zheng YT, Chen FE, Dai HF. Synthesis, structure-activity relationships, and docking studies of N-phenylarylformamide derivatives (PAFAs) as non-nucleoside HIV reverse transcriptase inhibitors. European Journal of Medicinal Chemistry. 58: 504-12. PMID 23164656 DOI: 10.1016/J.Ejmech.2012.03.032 |
0.37 |
|
| 2012 |
Gu SX, Li ZM, Ma XD, Yang SQ, He QQ, Chen FE, De Clercq E, Balzarini J, Pannecouque C. Chiral resolution, absolute configuration assignment and biological activity of racemic diarylpyrimidine CH(OH)-DAPY as potent nonnucleoside HIV-1 reverse transcriptase inhibitors. European Journal of Medicinal Chemistry. 53: 229-34. PMID 22575532 DOI: 10.1016/J.Ejmech.2012.04.004 |
0.349 |
|
| 2012 |
He QQ, Zhang X, Yang LM, Zheng YT, Chen F. Synthesis and biological evaluation of 5-fluoroquinolone-3-carboxylic acids as potential HIV-1 integrase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 28: 671-6. PMID 22468749 DOI: 10.3109/14756366.2012.668540 |
0.425 |
|
| 2012 |
Yang S, Chen FE, De Clercq E. Dihydro-alkoxyl-benzyl-oxopyrimidine derivatives (DABOs) as non-nucleoside reverse transcriptase inhibitors: an update review (2001-2011). Current Medicinal Chemistry. 19: 152-62. PMID 22320294 DOI: 10.2174/092986712803414169 |
0.402 |
|
| 2012 |
Miao Z, Chen F. Asymmetric Aldol Reactions of Heterocyclic Dienolsilanes and α,β-Unsaturated Carbonyl Derived Dienolsilanes Synthesis. 44: 3400-3400. DOI: 10.1055/S-0032-1316798 |
0.376 |
|
| 2012 |
Yang H, Dai L, Yang S, Chen F. Direct Bifunctional Squaramide-CatalyzedAsymmetric N-Nitroso Aldol Reactionof Tertiary β-Carbonyl Esters Synlett. 23: 948-950. DOI: 10.1055/S-0031-1290613 |
0.331 |
|
| 2012 |
Dai L, Yang H, Niu J, Chen F. Enantioselective Protonationin the Sulfa-Michael Addition Using Chiral Squaramides as Hydrogen-BondingOrganocatalysts Synlett. 2012: 314-316. DOI: 10.1055/S-0031-1290113 |
0.311 |
|
| 2012 |
Wang Z, Zheng C, Li F, Zhao L, Chen F, He Q. An Efficient EnantioselectiveSynthesis of Florfenicol Based on Sharpless Asymmetric Dihydroxylation Synthesis. 44: 699-704. DOI: 10.1055/S-0031-1289706 |
0.317 |
|
| 2012 |
Zhao L, Ma X, Chen F. Development of Two Scalable Syntheses of 4-Amino-5-aminomethyl-2-methylpyrimidine: Key Intermediate for Vitamin B1 Organic Process Research & Development. 16: 57-60. DOI: 10.1021/Op2002003 |
0.388 |
|
| 2011 |
Gu SX, Yang SQ, He QQ, Ma XD, Chen FE, Dai HF, Clercq ED, Balzarini J, Pannecouque C. Design, synthesis and biological evaluation of cycloalkyl arylpyrimidines (CAPYs) as HIV-1 NNRTIs. Bioorganic & Medicinal Chemistry. 19: 7093-9. PMID 22037050 DOI: 10.1016/J.Bmc.2011.10.002 |
0.41 |
|
| 2011 |
Ma XD, Yang SQ, Gu SX, He QQ, Chen FE, De Clercq E, Balzarini J, Pannecouque C. Synthesis and anti-HIV activity of aryl-2-[(4-cyanophenyl)amino]-4-pyrimidinone hydrazones as potent non-nucleoside reverse transcriptase inhibitors. Chemmedchem. 6: 2225-32. PMID 21990112 DOI: 10.1002/Cmdc.201100334 |
0.414 |
|
| 2011 |
He QQ, Zhang X, Wu HQ, Gu SX, Ma XD, Yang LM, Zheng YT, Chen FE. Synthesis and biological evaluation of HQCAs with aryl or benzyl substituents on N-1 position as potential HIV-1 integrase inhibitors. Bioorganic & Medicinal Chemistry. 19: 5553-8. PMID 21862337 DOI: 10.1016/J.Bmc.2011.07.037 |
0.43 |
|
| 2011 |
Gu SX, He QQ, Yang SQ, Ma XD, Chen FE, De Clercq E, Balzarini J, Pannecouque C. Synthesis and structure-activity relationship of novel diarylpyrimidines with hydromethyl linker (CH(OH)-DAPYs) as HIV-1 NNRTIs. Bioorganic & Medicinal Chemistry. 19: 5117-24. PMID 21824782 DOI: 10.1016/J.Bmc.2011.07.023 |
0.422 |
|
| 2011 |
Ma XD, Zhang X, Yang SQ, Dai HF, Yang LM, Gu SX, Zheng YT, He QQ, Chen FE. Synthesis and biological evaluation of (±)-benzhydrol derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. Bioorganic & Medicinal Chemistry. 19: 4704-9. PMID 21788138 DOI: 10.1016/J.Bmc.2011.07.003 |
0.42 |
|
| 2011 |
He QQ, Gu SX, Liu J, Wu HQ, Zhang X, Yang LM, Zheng YT, Chen FE. Structural modifications of quinolone-3-carboxylic acids with anti-HIV activity. Bioorganic & Medicinal Chemistry. 19: 5039-45. PMID 21763149 DOI: 10.1016/J.Bmc.2011.06.020 |
0.41 |
|
| 2011 |
Ma XD, Zhang X, Dai HF, Yang SQ, Yang LM, Gu SX, Zheng YT, He QQ, Chen FE. Synthesis and biological activity of naphthyl-substituted (B-ring) benzophenone derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. Bioorganic & Medicinal Chemistry. 19: 4601-7. PMID 21719299 DOI: 10.1016/J.Bmc.2011.06.007 |
0.437 |
|
| 2011 |
Gu SX, Zhang X, He QQ, Yang LM, Ma XD, Zheng YT, Yang SQ, Chen FE. Synthesis and biological evaluation of naphthyl phenyl ethers (NPEs) as novel nonnucleoside HIV-1 reverse transcriptase inhibitors. Bioorganic & Medicinal Chemistry. 19: 4220-6. PMID 21689939 DOI: 10.1016/J.Bmc.2011.05.060 |
0.421 |
|
| 2011 |
Chen XX, Xiong F, Fu H, Liu ZQ, Chen FE. Synthetic studies on (+)-biotin, part 15: A chiral squaramide-mediated enantioselective alcoholysis approach toward the total synthesis of (+)-biotin. Chemical & Pharmaceutical Bulletin. 59: 488-91. PMID 21467680 DOI: 10.1248/Cpb.59.488 |
0.386 |
|
| 2011 |
Zhao L, Xiong F, Chen W, Chen F. A Novel and EnantioselectiveTotal Synthesis of (20S)-Camptothecinvia a Sharpless Asymmetric Dihydroxylation Strategy Synthesis. 2011: 4045-4049. DOI: 10.1055/S-0031-1289575 |
0.425 |
|
| 2011 |
Huang J, Zhao L, Gu S, Wang Z, Zhang H, Chen F, Dai H. Efficient Asymmetric Synthesis of (2R,3R)-3-{(1R)-1-(tert-Butyl(dimethyl)- siloxy)ethyl}-4-oxoazetidin-2-yl Acetate Synthesis. 2011: 555-562. DOI: 10.1055/S-0030-1258407 |
0.313 |
|
| 2011 |
Li F, Wang Z, Zhao L, Xiong F, He Q, Chen F. An efficient enantioselective synthesis of florfenicol via a vanadium-catalyzed asymmetric epoxidation Tetrahedron-Asymmetry. 22: 1337-1341. DOI: 10.1016/J.Tetasy.2011.07.011 |
0.444 |
|
| 2011 |
Wang Z, Li F, Zhao L, He Q, Chen F, Zheng C. An efficient enantioselective synthesis of florfenicol via asymmetric aziridination Tetrahedron. 67: 9199-9203. DOI: 10.1016/J.Tet.2011.09.052 |
0.445 |
|
| 2011 |
Dai L, Yang H, Chen F. Chiral Squaramide‐Catalyzed Enantioselective Conjugate Michael Addition of Various Thiols to α,β‐Unsaturated N‐Acylated Oxazolidin‐2‐ones European Journal of Organic Chemistry. 2011: 5071-5076. DOI: 10.1002/Ejoc.201100403 |
0.352 |
|
| 2011 |
Chen X, Xiong F, Fu H, Liu Z, Chen F. ChemInform Abstract: Synthetic Studies on (+)-Biotin. Part 15. A Chiral Squaramide-Mediated Enantioselective Alcoholysis Approach Toward the Total Synthesis of (+)-Biotin (IV). Cheminform. 42: no-no. DOI: 10.1002/CHIN.201141190 |
0.303 |
|
| 2010 |
Chen WX, Zhang P, Chen FE. NMR studies on chiral intermediates in the total synthesis of (+)-biotin from D-mannose. Magnetic Resonance in Chemistry : Mrc. 48: 651-5. PMID 20623722 DOI: 10.1002/Mrc.2619 |
0.344 |
|
| 2010 |
Zeng ZS, He QQ, Liang YH, Feng XQ, Chen FE, De Clercq E, Balzarini J, Pannecouque C. Hybrid diarylbenzopyrimidine non-nucleoside reverse transcriptase inhibitors as promising new leads for improved anti-HIV-1 chemotherapy. Bioorganic & Medicinal Chemistry. 18: 5039-47. PMID 20598556 DOI: 10.1016/J.Bmc.2010.05.081 |
0.407 |
|
| 2010 |
Liang YH, He QQ, Zeng ZS, Liu ZQ, Feng XQ, Chen FE, Balzarini J, Pannecouque C, Clercq ED. Synthesis and anti-HIV activity of 2-naphthyl substituted DAPY analogues as non-nucleoside reverse transcriptase inhibitors. Bioorganic & Medicinal Chemistry. 18: 4601-5. PMID 20570527 DOI: 10.1016/J.Bmc.2010.05.036 |
0.433 |
|
| 2010 |
Zeng ZS, Liang YH, Feng XQ, Chen FE, Pannecouque C, Balzarini J, De Clercq E. Lead optimization of diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Chemmedchem. 5: 837-40. PMID 20333620 DOI: 10.1002/Cmdc.201000045 |
0.341 |
|
| 2010 |
Feng XQ, Zeng ZS, Liang YH, Chen FE, Pannecouque C, Balzarini J, De Clercq E. Synthesis and biological evaluation of 4-(hydroxyimino)arylmethyl diarylpyrimidine analogues as potential non-nucleoside reverse transcriptase inhibitors against HIV. Bioorganic & Medicinal Chemistry. 18: 2370-4. PMID 20307984 DOI: 10.1016/J.Bmc.2010.03.007 |
0.431 |
|
| 2010 |
Huang J, Chen X, Gu S, Zhao L, Chen W, Chen F. An Efficient Method for Removal of Residual Palladium from Organic Solution of Faropenem Sodium in the Pd(II)-Catalyzed Cleavage of Allyl Faropenem Organic Process Research & Development. 14: 939-941. DOI: 10.1021/Op100094P |
0.312 |
|
| 2010 |
Xiong F, Chen X, Liu Z, Chen F. A novel synthetic strategy for the stereospecific total synthesis of (±)-biotin Tetrahedron Letters. 51: 3670-3672. DOI: 10.1016/J.Tetlet.2010.05.035 |
0.341 |
|
| 2010 |
Xiong F, Chen X, Chen F. An improved asymmetric total synthesis of (+)-biotin via the enantioselective desymmetrization of a meso-cyclic anhydride mediated by cinchona alkaloid-based sulfonamide Tetrahedron: Asymmetry. 21: 665-669. DOI: 10.1016/J.Tetasy.2010.03.041 |
0.383 |
|
| 2010 |
Kuang Y, Niu J, Chen F. Synthetic Studies on Camptothecins. Part 3 Helvetica Chimica Acta. 93: 2094-2099. DOI: 10.1002/Hlca.201000049 |
0.412 |
|
| 2010 |
Dai L, Wang S, Chen F. A Bifunctional Cinchona Alkaloid‐Squaramide Catalyst for the Highly Enantioselective Conjugate Addition of Thiols to trans‐Chalcones Advanced Synthesis & Catalysis. 352: 2137-2141. DOI: 10.1002/Adsc.201000334 |
0.352 |
|
| 2009 |
Liang YH, Feng XQ, Zeng ZS, Chen FE, Balzarini J, Pannecouque C, De Clercq E. Design, synthesis, and SAR of naphthyl-substituted Diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Chemmedchem. 4: 1537-45. PMID 19591191 DOI: 10.1002/Cmdc.200900212 |
0.441 |
|
| 2009 |
Xiong YZ, Hu HR, Chen FE, Balzarini J, Pannecouque C, de Clercq E. Non-nucleoside reverse transcriptase inhibitors (Part 18): synthesis and anti-HIV activity of 4-allylamino or 4-azido substituted diaryltriazines. Yao Xue Xue Bao = Acta Pharmaceutica Sinica. 44: 145-9. PMID 19408683 |
0.301 |
|
| 2009 |
Xiong YZ, Chen FE, Balzarini J, De Clercq E, Pannecouque C. Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 13: synthesis of fluorine-containing diaryltriazine derivatives for in vitro anti-HIV evaluation against wild-type strain. Chemistry & Biodiversity. 6: 561-8. PMID 19353537 DOI: 10.1002/Cbdv.200800163 |
0.426 |
|
| 2009 |
Feng XQ, Liang YH, Zeng ZS, Chen FE, Balzarini J, Pannecouque C, De Clercq E. Structural modifications of DAPY analogues with potent anti-HIV-1 activity. Chemmedchem. 4: 219-24. PMID 19090525 DOI: 10.1002/Cmdc.200800334 |
0.407 |
|
| 2009 |
Wang YP, Chen FE, De Clercq E, Balzarini J, Pannecouque C. Synthesis and in vitro anti-HIV evaluation of a new series of 6-arylmethyl-substituted S-DABOs as potential non-nucleoside HIV-1 reverse transcriptase inhibitors. European Journal of Medicinal Chemistry. 44: 1016-23. PMID 18692274 DOI: 10.1016/J.Ejmech.2008.06.028 |
0.427 |
|
| 2009 |
Liang YH, Chen FE. QSAR studies for diarylpyrimidines against HIV-1 reverse transcriptase wild-type and mutant strains. European Journal of Medicinal Chemistry. 44: 625-31. PMID 18457904 DOI: 10.1016/J.Ejmech.2008.03.021 |
0.311 |
|
| 2009 |
Xiong X, Chen WX, Kuang YY, Chen FE. A Novel and Practical Synthesis of 2- Amino-5-hydroxypropiophenone Organic Preparations and Procedures International. 41: 423. DOI: DOI: 10.1080/00304940903187615 |
0.71 |
|
| 2009 |
Xiong X, Chen W, Kuang Y, Chen F. A Novel and Practical Synthesis of 2-Amino-5-hydroxypropiophenone Organic Preparations and Procedures International. 41: 423-427. DOI: 10.1080/00304940903187615 |
0.382 |
|
| 2009 |
Huang J, Xiong F, Wang Z, Chen F. Unexpected Ring Expansion of the (3aS,6aR)-γ-Thiolactone Moiety during the Introduction of the (+)-Biotin Side Chain Helvetica Chimica Acta. 92: 1445-1449. DOI: 10.1002/Hlca.200800435 |
0.318 |
|
| 2009 |
Wang SX, Chen FE. A novel cost-effective thiourea bifunctional organocatalyst for highly enantioselective alcoholysis of meso-cyclic anhydrides: Enhanced enantioselectivity by configuration inversion Advanced Synthesis and Catalysis. 351: 547-552. DOI: 10.1002/Adsc.200800761 |
0.363 |
|
| 2008 |
Yu X, Wang S, Chen F. Solid-phase synthesis of solanesol. Journal of Combinatorial Chemistry. 10: 605-10. PMID 18558751 DOI: 10.1021/Cc800069T |
0.321 |
|
| 2008 |
Wang YP, Chen FE, De Clercq E, Balzarini J, Pannecouque C. Synthesis and biological evaluation of novel 6-substituted 5-alkyl-2-(arylcarbonylmethylthio)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. Bioorganic & Medicinal Chemistry. 16: 3887-94. PMID 18267363 DOI: 10.1016/J.Bmc.2008.01.039 |
0.433 |
|
| 2008 |
Wang Y, Chen FE, Balzarini J, De Clercq E, Pannecouque C. Non-nucleoside HIV-1 reverse-transcriptase inhibitors. Part 10. Synthesis and anti-HIV activity of 5-alkyl-6-(1-naphthylmethyl)pyrimidin-4(3H)-ones with a mono- or disubstituted 2-amino function as novel 'dihydro-alkoxy-benzyl-oxopyrimidine' (DABO) analogues. Chemistry & Biodiversity. 5: 168-76. PMID 18205120 DOI: 10.1002/Cbdv.200890008 |
0.44 |
|
| 2008 |
Xiong YZ, Chen FE, Balzarini J, De Clercq E, Pannecouque C. Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 11: structural modulations of diaryltriazines with potent anti-HIV activity. European Journal of Medicinal Chemistry. 43: 1230-6. PMID 17869386 DOI: 10.1016/J.Ejmech.2007.08.001 |
0.411 |
|
| 2008 |
Huang J, Xiong F, Chen FE. Total synthesis of (+)-biotin via a quinine-mediated asymmetric alcoholysis of meso-cyclic anhydride strategy Tetrahedron Asymmetry. 19: 1435-1442. DOI: 10.1016/J.Tetasy.2008.05.020 |
0.36 |
|
| 2008 |
Zhang L, Bao Y, Kuang Y, Chen F. Synthetic Studies on Camptothecins Part 1 An Improved Asymmetric Total Synthesis of (20S)-Camptothecin Helvetica Chimica Acta. 91: 2057-2061. DOI: 10.1002/Hlca.200890218 |
0.452 |
|
| 2008 |
Yu X, Zhang H, Xiong F, Chen X, Chen F. An Improved Convergent Strategy for the Synthesis of Oligoprenols Helvetica Chimica Acta. 91: 1967-1974. DOI: 10.1002/Hlca.200890211 |
0.399 |
|
| 2008 |
Dai H, Chen W, Zhao L, Xiong F, Sheng H, Chen F. Synthetic Studies on (+)‐Biotin, Part 11: Application of Cinchona Alkaloid‐Mediated Asymmetric Alcoholysis of meso‐Cyclic Anhydride in the Total Synthesis of (+)‐Biotin Advanced Synthesis & Catalysis. 350: 1635-1641. DOI: 10.1002/Adsc.200800151 |
0.42 |
|
| 2007 |
Chen FE, Zhao JF, Xiong FJ, Xie B, Zhang P. An improved synthesis of a key intermediate for (+)-biotin from D-mannose. Carbohydrate Research. 342: 2461-4. PMID 17678881 DOI: 10.1016/J.Carres.2007.06.029 |
0.352 |
|
| 2007 |
Wang SX, Chen FE. Novel polymer-supported chiral catalysts for the asymmetric addition of diethylzinc to aldehydes Chemical and Pharmaceutical Bulletin. 55: 1011-1013. PMID 17603191 DOI: 10.1248/Cpb.55.1011 |
0.329 |
|
| 2007 |
Ji L, Chen FE, De Clercq E, Balzarini J, Pannecouque C. Synthesis and anti-HIV-1 activity evaluation of 5-alkyl-2-alkylthio-6-(arylcarbonyl or alpha-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. Journal of Medicinal Chemistry. 50: 1778-86. PMID 17381078 DOI: 10.1021/Jm061167R |
0.43 |
|
| 2007 |
Ji L, Chen FE, Xie B, De Clercq E, Balzarini J, Pannecouque C. Synthesis and anti-HIV activity evaluation of 1-[(alkenyl or alkynyl or alkyloxy)methyl]-5-alkyl-6-(1-naphthoyl)-2,4-pyrimidinediones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. European Journal of Medicinal Chemistry. 42: 198-204. PMID 17095124 DOI: 10.1016/J.Ejmech.2006.09.018 |
0.422 |
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| 2007 |
Liu J, Chen F, Chen M. (4R,5S)‐Methyl 1,3‐dibenzyl‐5‐[(R)‐2‐(hydroxydiphenylmethyl)pyrrolidine‐1‐carbonyl]‐2‐oxoimidazolidine‐4‐carboxylate Acta Crystallographica Section E-Structure Reports Online. 63. DOI: 10.1107/S1600536807045874 |
0.385 |
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| 2007 |
Bao Y, Chen F, Chen M. (4′S)‐4′‐Ethyl‐3′,10′‐dioxo‐3′,4′,7′,8′‐tetrahydrospiro[1,3‐dioxolane‐2,6′‐1′H,6′H‐pyrano[3,4‐f]indolizin]‐4′‐yl N‐(1‐phenylethyl)carbamate Acta Crystallographica Section E: Crystallographic Communications. 63. DOI: 10.1107/S1600536807038731 |
0.354 |
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| 2007 |
Wang Y, Chen F, Chen M. 6‐(2,6‐Dichlorobenzyl)‐5‐ethyl‐2‐(4‐methoxybenzylsulfanyl)pyrimidin‐4(3H)‐one Acta Crystallographica Section E-Structure Reports Online. 63. DOI: 10.1107/S1600536807034976 |
0.337 |
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| 2007 |
Dai L, Chen F, Chen M. (5R,6R)-Methyl 6-methyl-2-phenyl-5,6-dihydro-4H-1,3-oxazine-5-carboxylate Acta Crystallographica Section E-Structure Reports Online. 63. DOI: 10.1107/S1600536807015991 |
0.32 |
|
| 2007 |
Chen F, Xie B, Zhang P, Zhao J, Wang H, Zhao L. An Efficient and Green Oxidation of Vicinal Diols to Aldehydes Using Polymer-Supported (Diacetoxyiodo)benzene as the Oxidant Synlett. 2007: 619-622. DOI: 10.1055/S-2007-970745 |
0.309 |
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| 2007 |
Huang J, Chen F. An Efficient Synthesis of a Potential (−)-Reserpine Intermediate from (−)-Shikimic Acid of the Chiral Pool Helvetica Chimica Acta. 90: 1366-1372. DOI: 10.1002/Hlca.200790138 |
0.423 |
|
| 2007 |
Yu X, Dai H, Chen F. Synthetic Studies on Coenzyme Q10. Part 3 Helvetica Chimica Acta. 90: 967-971. DOI: 10.1002/Hlca.200790099 |
0.367 |
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| 2006 |
Ji L, Chen FE, Feng XQ, De Clercq E, Balzarini J, Pannecouque C. Non-nucleoside HIV-1 reverse transcriptase inhibitors, Part 7. Synthesis, antiviral activity, and 3D-QSAR investigations of novel 6-(1-naphthoyl) HEPT analogues. Chemical & Pharmaceutical Bulletin. 54: 1248-53. PMID 16946529 DOI: 10.1248/Cpb.54.1248 |
0.423 |
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| 2006 |
Kuang Y, Huang J, Chen F. Practical and Phase Transfer–Catalyzed Synthesis of 6‐Methoxytryptamine Synthetic Communications. 36: 1515-1519. DOI: 10.1080/00397910600588504 |
0.402 |
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| 2006 |
Dai H, Chen F, Yu X. Synthetic Studies on Coenzyme Q10. Part 2 Helvetica Chimica Acta. 89: 1317-1321. DOI: 10.1002/Hlca.200690130 |
0.317 |
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| 2005 |
Chen FE, Huang J. Reserpine: a challenge for total synthesis of natural products. Chemical Reviews. 105: 4671-706. PMID 16351058 DOI: 10.1021/Cr050521A |
0.322 |
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| 2005 |
Sun GF, Kuang YY, Chen FE, De Clercq E, Balzarini J, Pannecouque C. Non-nucleoside HIV reverse transcriptase inhibitors, Part 6[1]: synthesis and anti-HIV activity of novel 2-[(arylcarbonylmethyl)thio]-6-arylthio DABO analogues. Archiv Der Pharmazie. 338: 457-61. PMID 16211654 DOI: 10.1002/Ardp.200400961 |
0.4 |
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| 2005 |
Sun GF, Chen XX, Chen FE, Wang YP, De Clercq E, Balzarini J, Pannecouque C. Nonnucleoside HIV-1 reverse-transcriptase inhibitors, part 5. Synthesis and anti-HIV-1 activity of novel 6-naphthylthio HEPT analogues. Chemical & Pharmaceutical Bulletin. 53: 886-92. PMID 16079514 DOI: 10.1248/Cpb.53.886 |
0.368 |
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| 2005 |
Chen FE, Jia HQ, Chen XX, Dai HF, Xie B, Kuang YY, Zhao JF. Synthetic studies on d-biotin, part 9. An improved asymmetric synthetic route to d-biotin via Hoffmann-Roche lactone-thiolactone approach. Chemical & Pharmaceutical Bulletin. 53: 743-6. PMID 15997127 DOI: 10.1248/Cpb.53.743 |
0.357 |
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| 2005 |
Meng G, Kuang Y, Ji L, Chen F. Synthesis of 1-[(2-hydroxyethoxy)methyl]-6-(5,6,7,8-tetrahydronaphthylmethyl-1) thymine as novel inhibitor against drug-resistant HIV mutants Synthetic Communications. 35: 1095-1102. DOI: 10.1081/Scc-200054213 |
0.455 |
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| 2005 |
Kuang Y, Chen F. A convenient and efficient asymmetric synthesis of (S)-α-arylthiomethyl-α-hydroxybutyric acid esters Organic Preparations and Procedures International. 37: 184-188. DOI: 10.1080/00304940509354885 |
0.344 |
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| 2005 |
He Y, Kuang Y, Chen F, Wang S, Ji L, Clercq ED, Balzarini J, Pannecouque C. Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors, Part 4[1]. Synthesis and Anti-HIV Activity of N-1-β-Carbonyl-6-naphthyl-methyl Analogues of HEPT Monatshefte Fur Chemie. 136: 1233-1245. DOI: 10.1007/S00706-005-0325-8 |
0.426 |
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| 2005 |
Yu X, Chen F, Dai H, Chen X, Kuang Y, Xie B. Synthetic Studies on Coenzyme Q10 Helvetica Chimica Acta. 88: 2575-2581. DOI: 10.1002/Hlca.200590197 |
0.382 |
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| 2005 |
Chen F, Chen X, Dai H, Kuang Y, Xie B, Zhao J. Synthetic Studies on d‐Biotin, Part 8:[1] An Efficient Chemoenzymatic Approach to the Asymmetric Total Synthesis of d‐Biotin via a Polymer‐Supported PLE‐Mediated Desymmetrization of meso‐Symmetic Dicarboxylic Esters Advanced Synthesis & Catalysis. 347: 549-554. DOI: 10.1002/Adsc.200404311 |
0.411 |
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| 2004 |
He Y, Chen F, Yu X, Wang Y, De Clercq E, Balzarini J, Pannecouque C. Nonnucleoside HIV-1 reverse transcriptase inhibitors; part 3. Synthesis and antiviral activity of 5-alkyl-2-[(aryl and alkyloxyl-carbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones. Bioorganic Chemistry. 32: 536-48. PMID 15530994 DOI: 10.1016/J.Bioorg.2004.05.007 |
0.424 |
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| 2004 |
He Y, Chen F, Sun G, Wang Y, De Clercq E, Balzarini J, Pannecouque C. 5-Alkyl-2-[(aryl and alkyloxylcarbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones as an unique HIV reverse transcriptase inhibitors of S-DABO series. Bioorganic & Medicinal Chemistry Letters. 14: 3173-6. PMID 15149669 DOI: 10.1016/J.Bmcl.2004.04.008 |
0.405 |
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| 2004 |
Lu L, Chen F. A Novel and Convenient Synthesis of Coenzyme Q1 Synthetic Communications. 34: 4049-4053. DOI: 10.1081/Scc-200036578 |
0.395 |
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| 2004 |
Sun G, Kuang Y, Wang S, Chen F. A Simple and Convenient Synthesis of HEPT Analogues via a One‐Pot Reduction–Sulfenylation Reaction Synthetic Communications. 34: 2229-2235. DOI: 10.1081/Scc-120038506 |
0.404 |
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| 2004 |
Huo M, Kuang Y, Chen F. PRACTICAL ROUTE TO A β-KETOPHOSPHONATE, A KEY INTERMEDIATE FOR THE TOTAL SYNTHESIS OF 20(S)-CPT AND RELATED ANALOGUES Organic Preparations and Procedures International. 36: 331-335. DOI: 10.1080/00304940409458674 |
0.353 |
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| 2004 |
Yuan J, Dai H, Chen F. A NOVEL AND SIMPLE SYNTHESIS OF (1S, 2S)-2-AMINO-l-(p-NITROPHENYL)-3-TRITYLOXYPROPANOL Organic Preparations and Procedures International. 36: 164-166. DOI: 10.1080/00304940409355389 |
0.301 |
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| 2004 |
Chu Y, Kuang Y, Dai H, Lu L, Chen F. A PRACTICAL PROCEDURE FOR THE SYNTHESIS OF 3-((E)-5-(2,3,4,5-TETRAMETHOXY-6-METHYLPHENYL)-3METHYLPENT-3-ENYL)-2,2-DIMETHYLOXIRANE Organic Preparations and Procedures International. 36: 476-479. DOI: 10.1002/CHIN.200510100 |
0.302 |
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| 2003 |
Meng G, Chen FE, De Clercq E, Balzarini J, Pannecouque C. Nonnucleoside HIV-1 reverse transcriptase inhibitors: Part I. Synthesis and structure-activity relationship of 1-alkoxymethyl-5-alkyl-6-naphthylmethyl uracils as HEPT analogues. Chemical & Pharmaceutical Bulletin. 51: 779-89. PMID 12843582 DOI: 10.1248/Cpb.51.779 |
0.404 |
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| 2003 |
Meng G, He Y, Chen F. Hypophosphorous Acid-Iodine: An Efficient and Mild Reagent for Cleavage of N–C Bond Synthetic Communications. 33: 2593-2598. DOI: 10.1081/Scc-120021978 |
0.335 |
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| 2003 |
Chen F, Kuang Y, Dai H, Lu L, Huo M. A Selective and Mild Oxidation of Primary Amines to Nitriles with Trichloroisocyanuric Acid Synthesis. 2003: 2629-2631. DOI: 10.1055/S-2003-42431 |
0.392 |
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| 2003 |
Chen F, Dai H, Kuang Y, Jia H. Synthetic studies on d-biotin. Part 7: A practical asymmetric total synthesis of d-biotin via enantioselective reduction of meso-cyclic imide catalyzed by oxazborolidine Tetrahedron-Asymmetry. 14: 3667-3672. DOI: 10.1016/J.Tetasy.2003.08.034 |
0.439 |
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| 2003 |
Chen F, Yuan J, Dai H, Kuang Y, Chu Y. Synthetic Studies on d-Biotin, Part 6: An Expeditious and Enantiocontrolled Approach to the Total Synthesis of d-Biotin via a Polymer-Supported Chiral Oxazaborolidine-Catalyzed Reduction of meso-Cyclic Imide Strategy Synthesis. 2003: 2155-2160. DOI: 10.1002/CHIN.200407268 |
0.384 |
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| 2002 |
Chen F, Lu Y, He Y, Luo Y, Yan M. Tetrabutylammonium Peroxydisulfate In Organic Synthesis. Xii.[1] A Convenient And Practical Procedure For The Selective Oxidation Of Thiols To Disulfides With Tetrabutylammonium Peroxydisulfate Under Solvent-Free Conditions Synthetic Communications. 32: 3487-3492. DOI: 10.1081/Scc-120014782 |
0.353 |
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| 2002 |
Chen F, Li Y, Xu M, Jia H. Tetrabutylammonium Peroxydisulfate in Organic Synthesis; XIII. A Simple and Highly Efficient One-Pot Synthesis of Nitriles by Nickel-Catalyzed Oxidation of Primary Alcohols with Tetrabutylammonium Peroxydisulfate Synthesis. 2002: 1804-1806. DOI: 10.1055/S-2002-33906 |
0.377 |
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| 2001 |
Chen F, Ling X, He Y, Peng X. Tetrabutylammonium Peroxydisulfate in Organic Synthesis; XI. A Novel and Selective Approach to the Oxidative Deprotection of Allyl Ethers with Tetrabutylammonium Peroxydisulfate Synthesis. 2001: 1772-1774. DOI: 10.1055/S-2001-17515 |
0.346 |
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| 2000 |
Chen F, Liu J, Fu H, Peng Z, Shao L. Tetrabutylammonium Peroxydisulfate in Organic Synthesis; VII. a Facile and Efficient Method for the Regeneration of Carbonyl Compounds from Semicarbazones by Tetrabutylammonium Peroxydisulfate Synthetic Communications. 30: 2295-2299. DOI: 10.1080/00397910008086869 |
0.401 |
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| 2000 |
Chen F, Huang Y, Fu H, Cheng Y, Zhang D, Li Y, Peng Z. An Efficient and Enantioselective Synthesis of d-Biotin Synthesis. 2000: 2004-2008. DOI: 10.1055/S-2000-8716 |
0.364 |
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| 2000 |
Chen F, Fu H, Meng G, Cheng Y, Lü Y. Tetrabutylammoninm Peroxydisulfate in Organic Synthesis X. An Efficient Nickel-Catalyzed One-Pot Synthesis of Nitriles from Aldehydes by Oxidation with Tetrabutylammonium Peroxydisulfate Synthesis. 2000: 1519-1520. DOI: 10.1055/S-2000-7595 |
0.376 |
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| 2000 |
Chen F, Fu H, Meng G, Cheng Y, Hu Y. Tetrabutylammonium Peroxydisulfate in Organic Synthesis; IX: A Convenient Approach to the Synthesis of Fused Acetal Derivatives by Tetrabutylammonium Peroxydisulfate-Mediated Oxidative Cycloaddition of 1,3-Dicarbonyl Compounds to Cyclic Enol Ethers Synthesis. 2000: 1091-1094. DOI: 10.1055/S-2000-6312 |
0.421 |
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| 1999 |
Chen F, Liu A, Yan Q, Liu M, Zhang D, Shao L. Tetrabutylammonium Peroxydisulfate in Organic Synthesis; IV.1 An Efficient, Highly Selective and Oxidative Deoximation by Tetrabutylammonium Peroxydisulfate Synthetic Communications. 29: 1049-1056. DOI: 10.1080/00397919908086071 |
0.395 |
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| 1999 |
Chen F, Peng Z, Fu H, Liu J, Shao L. Tetrabutylammonium Peroxydisulfate in Organic Synthesis. Part 8. An Efficient and Convenient Nickel-catalyzed Oxidation of Primary Amines to Nitriles with Tetrabutylammonium Peroxydisulfate Journal of Chemical Research-S. 726-727. DOI: 10.1039/A906485K |
0.358 |
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