| Year |
Citation |
Score |
| 2023 |
Dowdell A, Paschke PI, Thomason PA, Tweedy L, Insall RH. Competition between chemoattractants causes unexpected complexity and can explain negative chemotaxis. Current Biology : Cb. 33: 1704-1715.e3. PMID 37001521 DOI: 10.1016/j.cub.2023.03.006 |
0.306 |
|
| 2022 |
Singh SP, Paschke P, Tweedy L, Insall RH. AKT and SGK kinases regulate cell migration by altering Scar/WAVE complex activation and Arp2/3 complex recruitment. Frontiers in Molecular Biosciences. 9: 965921. PMID 36106016 DOI: 10.3389/fmolb.2022.965921 |
0.41 |
|
| 2022 |
Singh SP, Insall RH. Under-Agarose Chemotaxis and Migration Assays for Dictyostelium. Methods in Molecular Biology (Clifton, N.J.). 2438: 467-482. PMID 35147958 DOI: 10.1007/978-1-0716-2035-9_27 |
0.361 |
|
| 2021 |
Singh SP, Thomason PA, Insall RH. Extracellular Signalling Modulates Scar/WAVE Complex Activity through Abi Phosphorylation. Cells. 10. PMID 34943993 DOI: 10.3390/cells10123485 |
0.368 |
|
| 2021 |
Williams RSB, Chubb JR, Insall R, King JS, Pears CJ, Thompson E, Weijer CJ. Moving the Research Forward: The Best of British Biology Using the Tractable Model System . Cells. 10. PMID 34831258 DOI: 10.3390/cells10113036 |
0.712 |
|
| 2021 |
Yang Y, Li D, Chao X, Singh SP, Thomason P, Yan Y, Dong M, Li L, Insall RH, Cai H. Leep1 interacts with PIP3 and the Scar/WAVE complex to regulate cell migration and macropinocytosis. The Journal of Cell Biology. 220. PMID 33978708 DOI: 10.1083/jcb.202010096 |
0.354 |
|
| 2020 |
Singh SP, Insall RH. Adhesion stimulates Scar/WAVE phosphorylation in mammalian cells. Communicative & Integrative Biology. 14: 1-4. PMID 33447346 DOI: 10.1080/19420889.2020.1855854 |
0.317 |
|
| 2020 |
Tweedy L, Thomason PA, Paschke PI, Martin K, Machesky LM, Zagnoni M, Insall RH. Seeing around corners: Cells solve mazes and respond at a distance using attractant breakdown. Science (New York, N.Y.). 369. PMID 32855311 DOI: 10.1126/Science.Aay9792 |
0.422 |
|
| 2020 |
Singh SP, Thomason PA, Lilla S, Schaks M, Tang Q, Goode BL, Machesky LM, Rottner K, Insall RH. Cell-substrate adhesion drives Scar/WAVE activation and phosphorylation by a Ste20-family kinase, which controls pseudopod lifetime. Plos Biology. 18: e3000774. PMID 32745097 DOI: 10.1371/Journal.Pbio.3000774 |
0.424 |
|
| 2020 |
Tweedy L, Insall RH. Self-Generated Gradients Yield Exceptionally Robust Steering Cues. Frontiers in Cell and Developmental Biology. 8: 133. PMID 32195256 DOI: 10.3389/Fcell.2020.00133 |
0.366 |
|
| 2020 |
Kadir SR, Insall RH, Moffatt G, McGhee J, Livingstone D. Analogies in 3D molecular visualisations: development of a cell biology animation 'How cells move - a new interpretation of old data'. Journal of Visual Communication in Medicine. 43: 35-46. PMID 31642358 DOI: 10.1080/17453054.2019.1671814 |
0.454 |
|
| 2020 |
Mackenzie JA, Nolan M, Insall RH. Local modulation of chemoattractant concentrations by single cells: dissection using a bulk-surface computational model. Interface Focus. 6: 20160036. PMID 27708760 DOI: 10.1098/Rsfs.2016.0036 |
0.379 |
|
| 2020 |
Insall R. Truth or beauty? Data and philosophy of cell biology Current Biology. 30: R245-R246. DOI: 10.1016/J.Cub.2020.02.039 |
0.351 |
|
| 2019 |
Buracco S, Claydon S, Insall R. Control of actin dynamics during cell motility. F1000research. 8. PMID 31824651 DOI: 10.12688/F1000Research.18669.1 |
0.456 |
|
| 2019 |
Amato C, Thomason PA, Davidson AJ, Swaminathan K, Ismail S, Machesky LM, Insall RH. WASP Restricts Active Rac to Maintain Cells' Front-Rear Polarization. Current Biology : Cb. PMID 31786060 DOI: 10.1016/J.Cub.2019.10.036 |
0.418 |
|
| 2019 |
Tweedy L, Witzel P, Heinrich D, Insall RH, Endres RG. Screening by changes in stereotypical behavior during cell motility. Scientific Reports. 9: 8784. PMID 31217532 DOI: 10.1038/S41598-019-45305-W |
0.346 |
|
| 2019 |
Paschke P, Knecht DA, Williams TD, Thomason PA, Insall RH, Chubb JR, Kay RR, Veltman DM. Genetic Engineering of Dictyostelium discoideum Cells Based on Selection and Growth on Bacteria. Journal of Visualized Experiments : Jove. PMID 30735174 DOI: 10.3791/58981 |
0.8 |
|
| 2019 |
Buckley CM, Heath VL, Guého A, Bosmani C, Knobloch P, Sikakana P, Personnic N, Dove SK, Michell RH, Meier R, Hilbi H, Soldati T, Insall RH, King JS. PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection. Plos Pathogens. 15: e1007551. PMID 30730983 DOI: 10.1371/Journal.Ppat.1007551 |
0.633 |
|
| 2019 |
Meissner M, Insall R, Hu K. Decision letter: Differential requirements for cyclase-associated protein (CAP) in actin-dependent processes of Toxoplasma gondii Elife. DOI: 10.7554/Elife.50598.050 |
0.307 |
|
| 2018 |
Schaks M, Singh SP, Kage F, Thomason P, Klünemann T, Steffen A, Blankenfeldt W, Stradal TE, Insall RH, Rottner K. Distinct Interaction Sites of Rac GTPase with WAVE Regulatory Complex Have Non-redundant Functions in Vivo. Current Biology : Cb. PMID 30393033 DOI: 10.1016/J.Cub.2018.10.002 |
0.38 |
|
| 2018 |
Fort L, Batista JM, Thomason PA, Spence HJ, Whitelaw JA, Tweedy L, Greaves J, Martin KJ, Anderson KI, Brown P, Lilla S, Neilson MP, Tafelmeyer P, Zanivan S, Ismail S, ... ... Insall RH, et al. Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. Nature Cell Biology. PMID 30250061 DOI: 10.1038/S41556-018-0198-9 |
0.48 |
|
| 2018 |
Song L, Rijal R, Karow M, Stumpf M, Hahn O, Park L, Insall R, Schröder R, Hofmann A, Clemen CS, Eichinger L. Expression of N471D strumpellin leads to defects in the endolysosomal system. Disease Models & Mechanisms. PMID 30061306 DOI: 10.1242/Dmm.033449 |
0.444 |
|
| 2018 |
Paschke P, Knecht DA, Silale A, Traynor D, Williams TD, Thomason PA, Insall RH, Chubb JR, Kay RR, Veltman DM. Rapid and efficient genetic engineering of both wild type and axenic strains of Dictyostelium discoideum. Plos One. 13: e0196809. PMID 29847546 DOI: 10.1371/Journal.Pone.0196809 |
0.779 |
|
| 2018 |
Visweshwaran SP, Thomason PA, Guerois R, Vacher S, Denisov EV, Tashireva LA, Lomakina ME, Lazennec-Schurdevin C, Lakisic G, Lilla S, Molinie N, Henriot V, Mechulam Y, Alexandrova AY, Cherdyntseva NV, ... ... Insall RH, et al. The trimeric coiled-coil HSBP1 protein promotes WASH complex assembly at centrosomes. The Embo Journal. 37. PMID 29844016 DOI: 10.15252/Embj.201797706 |
0.424 |
|
| 2018 |
Pan M, Neilson MP, Grunfeld AM, Cruz P, Wen X, Insall RH, Jin T. A G-protein-coupled chemoattractant receptor recognizes lipopolysaccharide for bacterial phagocytosis. Plos Biology. 16: e2005754. PMID 29799847 DOI: 10.1371/Journal.Pbio.2005754 |
0.32 |
|
| 2018 |
Heinrich D, Barnett R, Tweedy L, Insall R, Stallforth P, Winckler T. The Chemoattractant Glorin Is Inactivated by Ester Cleavage during Early Multicellular Development of Polysphondylium pallidum. Acs Chemical Biology. PMID 29792671 DOI: 10.1021/Acschembio.8B00046 |
0.345 |
|
| 2017 |
Davidson AJ, Amato C, Thomason PA, Insall RH. WASP family proteins and formins compete in pseudopod- and bleb-based migration. The Journal of Cell Biology. PMID 29191847 DOI: 10.1083/Jcb.201705160 |
0.462 |
|
| 2017 |
Susanto O, Koh YWH, Morrice N, Tumanov S, Thomason PA, Nielson M, Tweedy L, Muinonen-Martin AJ, Kamphorst JJ, Mackay GM, Insall RH. LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells. Journal of Cell Science. PMID 28871044 DOI: 10.1242/Jcs.207514 |
0.405 |
|
| 2017 |
Thomason PA, King JS, Insall RH. Mroh1, a lysosomal regulator localised by WASH-generated actin. Journal of Cell Science. PMID 28424231 DOI: 10.1242/Jcs.197210 |
0.668 |
|
| 2017 |
Periz J, Whitelaw J, Harding C, Gras S, Del Rosario Minina MI, Latorre-Barragan F, Lemgruber L, Reimer MA, Insall R, Heaslip A, Meissner M. Toxoplasma gondii F-actin forms an extensive filamentous network required for material exchange and parasite maturation. Elife. 6. PMID 28322189 DOI: 10.7554/Elife.24119 |
0.319 |
|
| 2017 |
Woodham EF, Paul NR, Tyrrell B, Spence HJ, Swaminathan K, Scribner MR, Giampazolias E, Hedley A, Clark W, Kage F, Marston DJ, Hahn KM, Tait SW, Larue L, Brakebusch CH, ... Insall RH, et al. Coordination by Cdc42 of Actin, Contractility, and Adhesion for Melanoblast Movement in Mouse Skin. Current Biology : Cb. PMID 28238662 DOI: 10.1016/J.Cub.2017.01.033 |
0.442 |
|
| 2016 |
Veltman DM, Williams TD, Bloomfield G, Chen BC, Betzig E, Insall RH, Kay RR. A plasma membrane template for macropinocytic cups. Elife. 5. PMID 27960076 DOI: 10.7554/Elife.20085 |
0.711 |
|
| 2016 |
Ferguson EA, Matthiopoulos J, Insall RH, Husmeier D. Inference of the drivers of collective movement in two cell types: Dictyostelium and melanoma. Journal of the Royal Society, Interface. 13. PMID 27798280 DOI: 10.1098/Rsif.2016.0695 |
0.329 |
|
| 2016 |
Buckley CM, Gopaldass N, Bosmani C, Johnston SA, Soldati T, Insall RH, King JS. WASH drives early recycling from macropinosomes and phagosomes to maintain surface phagocytic receptors. Proceedings of the National Academy of Sciences of the United States of America. PMID 27647881 DOI: 10.1073/Pnas.1524532113 |
0.661 |
|
| 2016 |
Tyrrell BJ, Woodham EF, Spence HJ, Strathdee D, Insall RH, Machesky LM. Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour. Pigment Cell & Melanoma Research. PMID 27390154 DOI: 10.1111/Pcmr.12506 |
0.418 |
|
| 2016 |
Tweedy L, Susanto O, Insall RH. Self-generated chemotactic gradients-cells steering themselves. Current Opinion in Cell Biology. 42: 46-51. PMID 27105308 DOI: 10.1016/J.Ceb.2016.04.003 |
0.308 |
|
| 2016 |
Tweedy L, Knecht DA, Mackay GM, Insall RH. Self-Generated Chemoattractant Gradients: Attractant Depletion Extends the Range and Robustness of Chemotaxis. Plos Biology. 14: e1002404. PMID 26981861 DOI: 10.1371/Journal.Pbio.1002404 |
0.358 |
|
| 2016 |
Frej AD, Clark J, Roy CL, Lilla S, Thomason P, Otto GP, Churchill G, Insall R, Claus SP, Hawkins P, Stephens L, Williams RS. The inositol-3-phosphate synthase biosynthetic enzyme has distinct catalytic and metabolic roles. Molecular and Cellular Biology. PMID 26951199 DOI: 10.1128/Mcb.00039-16 |
0.319 |
|
| 2016 |
Ferguson EA, Matthiopoulos J, Insall RH, Husmeier D. Statistical inference of the mechanisms driving collective cell movement Journal of the Royal Statistical Society: Series C (Applied Statistics). 66: 869-890. DOI: 10.1111/Rssc.12203 |
0.357 |
|
| 2015 |
Urushihara H, Kuwayama H, Fukuhara K, Itoh T, Kagoshima H, Shin-I T, Toyoda A, Ohishi K, Taniguchi T, Noguchi H, Kuroki Y, Hata T, Uchi K, Mohri K, King JS, ... Insall RH, et al. Comparative genome and transcriptome analyses of the social amoeba Acytostelium subglobosum that accomplishes multicellular development without germ-soma differentiation. Bmc Genomics. 16: 80. PMID 25758444 DOI: 10.1186/S12864-015-1278-X |
0.617 |
|
| 2014 |
Muinonen-Martin AJ, Susanto O, Zhang Q, Smethurst E, Faller WJ, Veltman DM, Kalna G, Lindsay C, Bennett DC, Sansom OJ, Herd R, Jones R, Machesky LM, Wakelam MJ, Knecht DA, ... Insall RH, et al. Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal. Plos Biology. 12: e1001966. PMID 25313567 DOI: 10.1371/Journal.Pbio.1001966 |
0.724 |
|
| 2014 |
Veltman DM, Lemieux MG, Knecht DA, Insall RH. PIP₃-dependent macropinocytosis is incompatible with chemotaxis. The Journal of Cell Biology. 204: 497-505. PMID 24535823 DOI: 10.1083/Jcb.201309081 |
0.76 |
|
| 2014 |
Tyrrell BJ, Neilson M, Insall RH, Machesky LM. Predicting cell shapes in melanomas. Pigment Cell & Melanoma Research. 27: 5-6. PMID 24118871 DOI: 10.1111/Pcmr.12176 |
0.403 |
|
| 2013 |
Davidson AJ, Insall RH. SCAR/WAVE: A complex issue. Communicative & Integrative Biology. 6: e27033. PMID 24753786 DOI: 10.4161/Cib.27033 |
0.422 |
|
| 2013 |
Davidson AJ, Ura S, Thomason PA, Kalna G, Insall RH. Abi is required for modulation and stability but not localization or activation of the SCAR/WAVE complex. Eukaryotic Cell. 12: 1509-16. PMID 24036345 DOI: 10.1128/Ec.00116-13 |
0.405 |
|
| 2013 |
Itakura A, Aslan JE, Kusanto BT, Phillips KG, Porter JE, Newton PK, Nan X, Insall RH, Chernoff J, McCarty OJ. p21-Activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils. Plos One. 8: e73063. PMID 24019894 DOI: 10.1371/Journal.Pone.0073063 |
0.384 |
|
| 2013 |
Insall RH. WASH complex conservation: don't WASH away the family! Trends in Cell Biology. 23: 519-20. PMID 23993425 DOI: 10.1016/J.Tcb.2013.07.009 |
0.334 |
|
| 2013 |
King JS, Gueho A, Hagedorn M, Gopaldass N, Leuba F, Soldati T, Insall RH. WASH is required for lysosomal recycling and efficient autophagic and phagocytic digestion. Molecular Biology of the Cell. 24: 2714-26. PMID 23885127 DOI: 10.1091/Mbc.E13-02-0092 |
0.653 |
|
| 2013 |
Muinonen-Martin AJ, Knecht DA, Veltman DM, Thomason PA, Kalna G, Insall RH. Measuring chemotaxis using direct visualization microscope chambers. Methods in Molecular Biology (Clifton, N.J.). 1046: 307-21. PMID 23868596 DOI: 10.1007/978-1-62703-538-5_18 |
0.697 |
|
| 2013 |
Davidson AJ, King JS, Insall RH. The use of streptavidin conjugates as immunoblot loading controls and mitochondrial markers for use with Dictyostelium discoideum. Biotechniques. 55: 39-41. PMID 23834384 DOI: 10.2144/000114054 |
0.591 |
|
| 2013 |
Insall R. The interaction between pseudopods and extracellular signalling during chemotaxis and directed migration. Current Opinion in Cell Biology. 25: 526-31. PMID 23747069 DOI: 10.1016/J.Ceb.2013.04.009 |
0.442 |
|
| 2013 |
Park L, Thomason PA, Zech T, King JS, Veltman DM, Carnell M, Ura S, Machesky LM, Insall RH. Cyclical action of the WASH complex: FAM21 and capping protein drive WASH recycling, not initial recruitment. Developmental Cell. 24: 169-81. PMID 23369714 DOI: 10.1016/J.Devcel.2012.12.014 |
0.796 |
|
| 2013 |
Tang H, Li A, Bi J, Veltman DM, Zech T, Spence HJ, Yu X, Timpson P, Insall RH, Frame MC, Machesky LM. Loss of Scar/WAVE complex promotes N-WASP- and FAK-dependent invasion. Current Biology : Cb. 23: 107-17. PMID 23273897 DOI: 10.1016/J.Cub.2012.11.059 |
0.701 |
|
| 2013 |
Choi CH, Thomason PA, Zaki M, Insall RH, Barber DL. Phosphorylation of actin-related protein 2 (Arp2) is required for normal development and cAMP chemotaxis in Dictyostelium. The Journal of Biological Chemistry. 288: 2464-74. PMID 23223240 DOI: 10.1074/Jbc.M112.435313 |
0.472 |
|
| 2012 |
Spence HJ, Timpson P, Tang HR, Insall RH, Machesky LM. Scar/WAVE3 contributes to motility and plasticity of lamellipodial dynamics but not invasion in three dimensions. The Biochemical Journal. 448: 35-42. PMID 22909346 DOI: 10.1042/Bj20112206 |
0.4 |
|
| 2012 |
Veltman DM, King JS, Machesky LM, Insall RH. SCAR knockouts in Dictyostelium: WASP assumes SCAR's position and upstream regulators in pseudopods. The Journal of Cell Biology. 198: 501-8. PMID 22891261 DOI: 10.1083/Jcb.201205058 |
0.796 |
|
| 2012 |
Ura S, Pollitt AY, Veltman DM, Morrice NA, Machesky LM, Insall RH. Pseudopod growth and evolution during cell movement is controlled through SCAR/WAVE dephosphorylation. Current Biology : Cb. 22: 553-61. PMID 22386315 DOI: 10.1016/J.Cub.2012.02.020 |
0.788 |
|
| 2012 |
Pakes NK, Veltman DM, Rivero F, Nasir J, Insall R, Williams RS. The Rac GEF ZizB regulates development, cell motility and cytokinesis in Dictyostelium. Journal of Cell Science. 125: 2457-65. PMID 22366457 DOI: 10.1242/Jcs.100966 |
0.756 |
|
| 2012 |
Insall R. How a paper on RAC set the standard. Nature Reviews. Molecular Cell Biology. 13: 66. PMID 22266759 DOI: 10.1038/Nrm3277 |
0.392 |
|
| 2012 |
Pakes NK, Veltman DM, Rivero F, Nasir J, Insall R, Williams RSB. The Rac GEF ZizB regulates development, cell motility and cytokinesis in Dictyostelium Development. 139: e1-e1. DOI: 10.1242/Dev.086082 |
0.439 |
|
| 2012 |
Itakura A, Aslan JE, Kusanto BT, Phillips KG, Insall RH, Chernoff J, McCarty OJ. p21-Activated Kinases Regulate Directional Migration and Cytoskeletal Organization in Human Neutrophils Blood. 120: 834-834. DOI: 10.1182/Blood.V120.21.834.834 |
0.371 |
|
| 2011 |
Zech T, Calaminus SD, Caswell P, Spence HJ, Carnell M, Insall RH, Norman J, Machesky LM. The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration. Journal of Cell Science. 124: 3753-9. PMID 22114305 DOI: 10.1242/Jcs.080986 |
0.403 |
|
| 2011 |
King JS, Veltman DM, Insall RH. The induction of autophagy by mechanical stress. Autophagy. 7: 1490-9. PMID 22024750 DOI: 10.4161/Auto.7.12.17924 |
0.761 |
|
| 2011 |
Li A, Ma Y, Yu X, Mort RL, Lindsay CR, Stevenson D, Strathdee D, Insall RH, Chernoff J, Snapper SB, Jackson IJ, Larue L, Sansom OJ, Machesky LM. Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression. Developmental Cell. 21: 722-34. PMID 21924960 DOI: 10.1016/J.Devcel.2011.07.008 |
0.461 |
|
| 2011 |
Neilson MP, Veltman DM, van Haastert PJ, Webb SD, Mackenzie JA, Insall RH. Chemotaxis: a feedback-based computational model robustly predicts multiple aspects of real cell behaviour. Plos Biology. 9: e1000618. PMID 21610858 DOI: 10.1371/Journal.Pbio.1000618 |
0.792 |
|
| 2011 |
Carnell M, Zech T, Calaminus SD, Ura S, Hagedorn M, Johnston SA, May RC, Soldati T, Machesky LM, Insall RH. Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis. The Journal of Cell Biology. 193: 831-9. PMID 21606208 DOI: 10.1083/Jcb.201009119 |
0.381 |
|
| 2011 |
Veltman DM, Auciello G, Spence HJ, MacHesky LM, Rappoport JZ, Insall RH. Functional analysis of Dictyosteliuin IBARa reveals a conserved role of the l-BAR domain in endocytosis Biochemical Journal. 436: 45-52. PMID 21401524 DOI: 10.1042/Bj20101684 |
0.719 |
|
| 2011 |
Davidson AJ, Insall RH. Actin-based motility: WAVE regulatory complex structure reopens old SCARs. Current Biology : Cb. 21: R66-8. PMID 21256435 DOI: 10.1016/J.Cub.2010.12.001 |
0.404 |
|
| 2011 |
Carnell MJ, Insall RH. Actin on disease--studying the pathobiology of cell motility using Dictyostelium discoideum. Seminars in Cell & Developmental Biology. 22: 82-8. PMID 21145982 DOI: 10.1016/J.Semcdb.2010.12.003 |
0.45 |
|
| 2011 |
Insall RH. Dogma bites back--the evidence for branched actin. Trends in Cell Biology. 21: 2; author reply 4-5. PMID 21144752 DOI: 10.1016/J.Tcb.2010.11.002 |
0.379 |
|
| 2011 |
Neilson MP, Mackenzie JA, Webb SD, Insall RH. Modeling cell movement and chemotaxis using pseudopod-based feedback Siam Journal On Scientific Computing. 33: 1035-1057. DOI: 10.1137/100788938 |
0.36 |
|
| 2010 |
Muinonen-Martin AJ, Veltman DM, Kalna G, Insall RH. An improved chamber for direct visualisation of chemotaxis. Plos One. 5: e15309. PMID 21179457 DOI: 10.1371/Journal.Pone.0015309 |
0.705 |
|
| 2010 |
Neilson MP, Mackenzie JA, Webb SD, Insall RH. Use of the parameterised finite element method to robustly and efficiently evolve the edge of a moving cell. Integrative Biology : Quantitative Biosciences From Nano to Macro. 2: 687-95. PMID 20959932 DOI: 10.1039/C0Ib00047G |
0.367 |
|
| 2010 |
Veltman DM, Insall RH. WASP family proteins: their evolution and its physiological implications. Molecular Biology of the Cell. 21: 2880-93. PMID 20573979 DOI: 10.1091/Mbc.E10-04-0372 |
0.722 |
|
| 2010 |
King JS, Veltman DM, Georgiou M, Baum B, Insall RH. SCAR/WAVE is activated at mitosis and drives myosin-independent cytokinesis. Journal of Cell Science. 123: 2246-55. PMID 20530573 DOI: 10.1242/Jcs.063735 |
0.817 |
|
| 2010 |
Insall RH. Understanding eukaryotic chemotaxis: a pseudopod-centred view. Nature Reviews. Molecular Cell Biology. 11: 453-8. PMID 20445546 DOI: 10.1038/Nrm2905 |
0.341 |
|
| 2009 |
Insall RH, Machesky LM. Actin dynamics at the leading edge: from simple machinery to complex networks. Developmental Cell. 17: 310-22. PMID 19758556 DOI: 10.1016/J.Devcel.2009.08.012 |
0.436 |
|
| 2009 |
King JS, Insall RH. Chemotaxis: finding the way forward with Dictyostelium. Trends in Cell Biology. 19: 523-30. PMID 19733079 DOI: 10.1016/J.Tcb.2009.07.004 |
0.672 |
|
| 2009 |
Pollitt AY, Insall RH. WASP and SCAR/WAVE proteins: the drivers of actin assembly. Journal of Cell Science. 122: 2575-8. PMID 19625501 DOI: 10.1242/Jcs.023879 |
0.762 |
|
| 2009 |
Pollitt AY, Insall RH. Loss of Dictyostelium HSPC300 causes a scar-like phenotype and loss of SCAR protein. Bmc Cell Biology. 10: 13. PMID 19228419 DOI: 10.1186/1471-2121-10-13 |
0.734 |
|
| 2008 |
King JS, Insall RH. Chemotaxis: TorC before you Akt... Current Biology : Cb. 18: R864-6. PMID 18812082 DOI: 10.1016/J.Cub.2008.07.051 |
0.621 |
|
| 2008 |
Heath RJ, Insall RH. F-BAR domains: multifunctional regulators of membrane curvature. Journal of Cell Science. 121: 1951-4. PMID 18525024 DOI: 10.1242/Jcs.023895 |
0.311 |
|
| 2008 |
Heath RJ, Insall RH. Dictyostelium MEGAPs: F-BAR domain proteins that regulate motility and membrane tubulation in contractile vacuoles. Journal of Cell Science. 121: 1054-64. PMID 18334553 DOI: 10.1242/Jcs.021113 |
0.412 |
|
| 2008 |
Pollitt AY, Insall RH. Abi mutants in Dictyostelium reveal specific roles for the SCAR/WAVE complex in cytokinesis. Current Biology : Cb. 18: 203-10. PMID 18261908 DOI: 10.1016/J.Cub.2008.01.026 |
0.756 |
|
| 2007 |
Insall R, Andrew N. Chemotaxis in Dictyostelium: how to walk straight using parallel pathways Current Opinion in Microbiology. 10: 578-581. PMID 18032093 DOI: 10.1016/J.Mib.2007.10.004 |
0.376 |
|
| 2007 |
Zaki M, King J, Fütterer K, Insall RH. Replacement of the essential Dictyostelium Arp2 gene by its Entamoeba homologue using parasexual genetics. Bmc Genetics. 8: 28. PMID 17553170 DOI: 10.1186/1471-2156-8-28 |
0.66 |
|
| 2007 |
Kae H, Kortholt A, Rehmann H, Insall RH, Van Haastert PJ, Spiegelman GB, Weeks G. Cyclic AMP signalling in Dictyostelium: G-proteins activate separate Ras pathways using specific RasGEFs. Embo Reports. 8: 477-82. PMID 17380187 DOI: 10.1038/Sj.Embor.7400936 |
0.664 |
|
| 2007 |
Calaminus SD, McCarty OJ, Auger JM, Pearce AC, Insall RH, Watson SP, Machesky LM. A major role for Scar/WAVE-1 downstream of GPVI in platelets. Journal of Thrombosis and Haemostasis : Jth. 5: 535-41. PMID 17319906 DOI: 10.1111/J.1538-7836.2007.02377.X |
0.409 |
|
| 2007 |
Andrew N, Insall RH. Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions Nature Cell Biology. 9: 193-200. PMID 17220879 DOI: 10.1038/Ncb1536 |
0.383 |
|
| 2006 |
King J, Insall R. Parasexual genetics using axenic cells. Methods in Molecular Biology (Clifton, N.J.). 346: 125-35. PMID 16957288 DOI: 10.1385/1-59745-144-4:125 |
0.621 |
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| 2006 |
Somesh BP, Vlahou G, Iijima M, Insall RH, Devreotes P, Rivero F. RacG regulates morphology, phagocytosis, and chemotaxis. Eukaryotic Cell. 5: 1648-63. PMID 16950926 DOI: 10.1128/Ec.00221-06 |
0.636 |
|
| 2006 |
Insall RH, Jones GE. Moving matters: signals and mechanisms in directed cell migration. Nature Cell Biology. 8: 776-9. PMID 16880806 DOI: 10.1038/Ncb0806-776 |
0.436 |
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| 2006 |
Pollitt AY, Blagg SL, Ibarra N, Insall RH. Cell motility and SCAR localisation in axenically growing Dictyostelium cells. European Journal of Cell Biology. 85: 1091-8. PMID 16822579 DOI: 10.1016/J.Ejcb.2006.05.014 |
0.751 |
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| 2006 |
Ibarra N, Blagg SL, Vazquez F, Insall RH. Nap1 regulates Dictyostelium cell motility and adhesion through SCAR-dependent and -independent pathways. Current Biology : Cb. 16: 717-22. PMID 16581519 DOI: 10.1016/J.Cub.2006.02.068 |
0.509 |
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| 2006 |
Ibarra N, Pollitt A, Insall RH. Regulation of actin assembly by SCAR/WAVE proteins. Biochemical Society Transactions. 33: 1243-6. PMID 16246088 DOI: 10.1042/Bst20051243 |
0.757 |
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| 2005 |
Wilkins A, Szafranski K, Fraser DJ, Bakthavatsalam D, Müller R, Fisher PR, Glöckner G, Eichinger L, Noegel AA, Insall RH. The Dictyostelium genome encodes numerous RasGEFs with multiple biological roles. Genome Biology. 6: R68. PMID 16086850 DOI: 10.1186/Gb-2005-6-8-R68 |
0.341 |
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| 2005 |
Insall R. The Dictyostelium genome: the private life of a social model revealed? Genome Biology. 6: 222. PMID 15960812 DOI: 10.1186/Gb-2005-6-6-222 |
0.304 |
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| 2005 |
Zouwail S, Pettitt TR, Dove SK, Chibalina MV, Powner DJ, Haynes L, Wakelam MJ, Insall RH. Phospholipase D activity is essential for actin localization and actin-based motility in Dictyostelium. The Biochemical Journal. 389: 207-14. PMID 15769249 DOI: 10.1042/Bj20050085 |
0.385 |
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| 2005 |
Blagg SL, Insall RH. Control of SCAR activity in Dictyostelium discoideum. Biochemical Society Transactions. 32: 1113-4. PMID 15506982 DOI: 10.1042/Bst0321113 |
0.388 |
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| 2005 |
Ibarra N, Pollitt A, Insall R. Regulation of actin assembly by SCAR/WAVE proteins Biochemical Society Transactions. 33: 1243-1246. DOI: 10.1042/bst0331243 |
0.742 |
|
| 2004 |
Secko DM, Insall RH, Spiegelman GB, Weeks G. The identification of Dictyostelium phosphoproteins altered in response to the activation of RasG. Proteomics. 4: 2629-39. PMID 15352238 DOI: 10.1002/Pmic.200300788 |
0.382 |
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| 2004 |
Insall RH, Machesky LM. Regulation of WASP: PIP2 Pipped by Toca-1? Cell. 118: 140-1. PMID 15260983 DOI: 10.1016/J.Cell.2004.07.005 |
0.458 |
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| 2004 |
Morgan CP, Insall R, Haynes L, Cockcroft S. Identification of phospholipase B from Dictyostelium discoideum reveals a new lipase family present in mammals, flies and nematodes, but not yeast. The Biochemical Journal. 382: 441-9. PMID 15193148 DOI: 10.1042/Bj20040110 |
0.306 |
|
| 2004 |
Blagg SL, Insall RH. Solving the WAVE function. Nature Cell Biology. 6: 279-81. PMID 15057236 DOI: 10.1038/Ncb0404-279 |
0.412 |
|
| 2004 |
Insall R. Dispatch. Dictyostelium chemotaxis: fascism through the back door? Current Biology : Cb. 13: R353-4. PMID 12725750 DOI: 10.1016/S0960-9822(03)00274-4 |
0.357 |
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| 2003 |
Blagg SL, Stewart M, Sambles C, Insall RH. PIR121 regulates pseudopod dynamics and SCAR activity in Dictyostelium. Current Biology : Cb. 13: 1480-7. PMID 12956949 DOI: 10.1016/S0960-9822(03)00580-3 |
0.354 |
|
| 2003 |
Insall R. Protein conformation: through a lens, darkly. The Biochemical Journal. 372: e1-2. PMID 12939165 DOI: 10.1042/Bj20030358Com |
0.316 |
|
| 2003 |
King J, Insall RH. Parasexual genetics of Dictyostelium gene disruptions: identification of a ras pathway using diploids. Bmc Genetics. 4: 12. PMID 12854977 DOI: 10.1186/1471-2156-4-12 |
0.598 |
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| 2003 |
Anderson SI, Behrendt B, Machesky LM, Insall RH, Nash GB. Linked regulation of motility and integrin function in activated migrating neutrophils revealed by interference in remodelling of the cytoskeleton. Cell Motility and the Cytoskeleton. 54: 135-46. PMID 12529859 DOI: 10.1002/Cm.10091 |
0.39 |
|
| 2002 |
Chubb JR, Wilkins A, Wessels DJ, Soll DR, Insall RH. Pseudopodium dynamics and rapid cell movement in Dictyostelium Ras pathway mutants. Cell Motility and the Cytoskeleton. 53: 150-62. PMID 12211111 DOI: 10.1002/Cm.10064 |
0.728 |
|
| 2001 |
Insall R, Müller-Taubenberger A, Machesky L, Köhler J, Simmeth E, Atkinson SJ, Weber I, Gerisch G. Dynamics of the Dictyostelium Arp2/3 complex in endocytosis, cytokinesis, and chemotaxis Cell Motility and the Cytoskeleton. 50: 115-128. PMID 11807934 DOI: 10.1002/Cm.10005 |
0.427 |
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| 2001 |
Insall RH, Weiner OD. PIP3, PIP2, and cell movement--similar messages, different meanings? Developmental Cell. 1: 743-7. PMID 11740936 DOI: 10.1016/S1534-5807(01)00086-7 |
0.322 |
|
| 2001 |
Chubb JR, Insall RH. Dictyostelium: an ideal organism for genetic dissection of Ras signalling networks. Biochimica Et Biophysica Acta. 1525: 262-71. PMID 11257439 DOI: 10.1016/S0304-4165(01)00111-8 |
0.679 |
|
| 2001 |
Wilkins A, Insall RH. Small GTPases in Dictyostelium: lessons from a social amoeba. Trends in Genetics : Tig. 17: 41-8. PMID 11163921 DOI: 10.1016/S0168-9525(00)02181-8 |
0.39 |
|
| 2001 |
Wilkins A, Chubb JR, Insall RH. A novel Dictyostelium RasGEF is required for normal endocytosis, cell motility and multicellular development. Current Biology : Cb. 10: 1427-37. PMID 11102804 DOI: 10.1016/S0960-9822(00)00797-1 |
0.674 |
|
| 2001 |
Insall RH. The Whole Organism, and nothing but the Organism Cell. 107: 279-281. DOI: 10.1016/S0092-8674(01)00558-X |
0.392 |
|
| 2000 |
Insall R. The PKB that doesn’t need to jump Trends in Genetics. 16: 441. PMID 11050328 DOI: 10.1016/S0168-9525(00)02130-2 |
0.414 |
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| 2000 |
Traynor D, Milne JL, Insall RH, Kay RR. Ca(2+) signalling is not required for chemotaxis in Dictyostelium. The Embo Journal. 19: 4846-54. PMID 10970875 DOI: 10.1093/Emboj/19.17.4846 |
0.315 |
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| 2000 |
Wilkins A, Khosla M, Fraser DJ, Spiegelman GB, Fisher PR, Weeks G, Insall RH. Dictyostelium RasD is required for normal phototaxis, but not differentiation Genes and Development. 14: 1407-1413. PMID 10837033 DOI: 10.1101/Gad.14.11.1407 |
0.395 |
|
| 2000 |
Rozelle AL, Machesky LM, Yamamoto M, Driessens MH, Insall RH, Roth MG, Luby-Phelps K, Marriott G, Hall A, Yin HL. Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3. Current Biology : Cb. 10: 311-20. PMID 10744973 DOI: 10.1016/S0960-9822(00)00384-5 |
0.402 |
|
| 2000 |
SWIGART P, INSALL R, WILKINS A, COCKCROFT S. Purification and cloning of phosphatidylinositol transfer proteins from Dictyostelium discoideum: homologues of both mammalian PITPs and Saccharomyces cerevisiae Sec14p are found in the same cell Biochemical Journal. 347: 837-843. DOI: 10.1042/Bj3470837 |
0.393 |
|
| 1999 |
Lee S, Parent CA, Insall R, Firtel RA. A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium. Molecular Biology of the Cell. 10: 2829-45. PMID 10473630 DOI: 10.1091/Mbc.10.9.2829 |
0.455 |
|
| 1999 |
Machesky LM, Insall RH. Signaling to actin dynamics. The Journal of Cell Biology. 146: 267-72. PMID 10427083 DOI: 10.1083/Jcb.146.2.267 |
0.407 |
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| 1999 |
Machesky LM, Insall RH. Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex. Current Biology : Cb. 8: 1347-56. PMID 9889097 DOI: 10.1016/S0960-9822(98)00015-3 |
0.439 |
|
| 1999 |
Insall R. PKB starts to jump Trends in Genetics. 15: 260. DOI: 10.1016/S0168-9525(99)01802-8 |
0.419 |
|
| 1998 |
Machesky LM, Insall RH, Kay RR. The helC gene encodes a putative DEAD-box RNA helicase required for development in Dictyostelium discoideum. Current Biology : Cb. 8: 607-10. PMID 9601648 DOI: 10.1016/S0960-9822(98)70233-7 |
0.332 |
|
| 1997 |
Tuxworth RI, Cheetham JL, Machesky LM, Spiegelmann GB, Weeks G, Insall RH. Dictyostelium RasG is required for normal motility and cytokinesis, but not growth Journal of Cell Biology. 138: 605-614. PMID 9245789 DOI: 10.1083/Jcb.138.3.605 |
0.455 |
|
| 1997 |
Aubry L, Maeda M, Insall R, Devreotes PN, Firtel RA. The Dictyostelium mitogen-activated protein kinase ERK2 is regulated by Ras and cAMP-dependent protein kinase (PKA) and mediates PKA function. The Journal of Biological Chemistry. 272: 3883-6. PMID 9020088 DOI: 10.1074/Jbc.272.7.3883 |
0.58 |
|
| 1997 |
Insall RH. Cyclic GMP and the big squeeze. Osmoregulation. Current Biology : Cb. 6: 516-8. PMID 8805270 DOI: 10.1016/S0960-9822(02)00530-4 |
0.323 |
|
| 1997 |
Insall RH, Borleis J, Devreotes PN. The aimless RasGEF is required for processing of chemotactic signals through G-protein-coupled receptors in Dictyostelium. Current Biology : Cb. 6: 719-29. PMID 8793298 DOI: 10.1016/S0960-9822(09)00453-9 |
0.571 |
|
| 1996 |
Chen MY, Insall RH, Devreotes PN. Signaling through chemoattractant receptors in Dictyostelium. Trends in Genetics : Tig. 12: 52-7. PMID 8851971 DOI: 10.1016/0168-9525(96)81400-4 |
0.597 |
|
| 1996 |
Maeda M, Aubry L, Insall R, Gaskins C, Devreotes PN, Firtel RA. Seven helix chemoattractant receptors transiently stimulate mitogen-activated protein kinase in Dictyostelium. Role of heterotrimeric G proteins. The Journal of Biological Chemistry. 271: 3351-4. PMID 8631932 DOI: 10.1074/Jbc.271.7.3351 |
0.561 |
|
| 1994 |
Insall R, Kuspa A, Lilly PJ, Shaulsky G, Levin LR, Loomis WF, Devreotes P. CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium Journal of Cell Biology. 126: 1537-1545. PMID 8089184 DOI: 10.1083/Jcb.126.6.1537 |
0.595 |
|
| 1994 |
Insall RH, Soede RD, Schaap P, Devreotes PN. Two cAMP receptors activate common signaling pathways in Dictyostelium. Molecular Biology of the Cell. 5: 703-11. PMID 7949426 DOI: 10.1091/Mbc.5.6.703 |
0.58 |
|
| 1993 |
Pupillo M, Insall R, Pitt GS, Devreotes PN. Multiple cyclic AMP receptors are linked to adenylyl cyclase in Dictyostelium. Molecular Biology of the Cell. 3: 1229-34. PMID 1333842 DOI: 10.1091/Mbc.3.11.1229 |
0.567 |
|
| 1992 |
Insall R, Nayler O, Kay R. DIF-1 induces its own breakdown in Dictyostelium. The Embo Journal. 11: 2849-2854. DOI: 10.1002/J.1460-2075.1992.Tb05352.X |
0.393 |
|
| 1990 |
Insall R, Kay RR. A specific DIF binding protein in Dictyostelium. The Embo Journal. 9: 3323-3328. DOI: 10.1002/J.1460-2075.1990.Tb07532.X |
0.331 |
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