| Year |
Citation |
Score |
| 2014 |
Ledley FD, McNamee LM, Uzdil V, Morgan IW. Why commercialization of gene therapy stalled; examining the life cycles of gene therapy technologies. Gene Therapy. 21: 188-94. PMID 24305420 DOI: 10.1038/Gt.2013.72 |
0.346 |
|
| 2000 |
Rosenberg SA, Blaese RM, Brenner MK, Deisseroth AB, Ledley FD, Lotze MT, Wilson JM, Nabel GJ, Cornetta K, Economou JS, Freeman SM, Riddell SR, Brenner M, Oldfield E, Gansbacher B, et al. Human gene marker/therapy clinical protocols. Human Gene Therapy. 11: 919-79. PMID 10779168 DOI: 10.1089/10430340050015536 |
0.374 |
|
| 1998 |
Shapiro Ledley T, Ledley FD. Pharmacokinetic considerations in somatic gene therapy. Advanced Drug Delivery Reviews. 30: 133-150. PMID 10837607 DOI: 10.1016/S0169-409X(97)00112-9 |
0.413 |
|
| 1997 |
Ledley FD, Rosenblatt DS. Mutations in mut methylmalonic acidemia: clinical and enzymatic correlations. Human Mutation. 9: 1-6. PMID 8990001 DOI: 10.1002/(Sici)1098-1004(1997)9:1<1::Aid-Humu1>3.0.Co;2-E |
0.304 |
|
| 1996 |
Ledley FD. Pharmaceutical approach to somatic gene therapy. Pharmaceutical Research. 13: 1595-614. PMID 8956323 DOI: 10.1023/A:1016420102549 |
0.396 |
|
| 1995 |
Adams RM, Wang M, Crane AM, Brown B, Darlington GJ, Ledley FD. Effective cryopreservation and long-term storage of primary human hepatocytes with recovery of viability, differentiation, and replicative potential. Cell Transplantation. 4: 579-86. PMID 8714779 DOI: 10.1016/0963-6897(95)02001-Q |
0.335 |
|
| 1995 |
Lau C, Soriano HE, Ledley FD, Finegold MJ, Wolfe JH, Birkenmeier EH, Henning SJ. Retroviral gene transfer into the intestinal epithelium. Human Gene Therapy. 6: 1145-51. PMID 8527472 DOI: 10.1089/Hum.1995.6.9-1145 |
0.379 |
|
| 1995 |
Ledley FD. Nonviral gene therapy: the promise of genes as pharmaceutical products. Human Gene Therapy. 6: 1129-44. PMID 8527471 DOI: 10.1089/Hum.1995.6.9-1129 |
0.405 |
|
| 1995 |
Ledley FD. After gene therapy: issues in long-term clinical follow-up and care. Advances in Genetics. 32: 1-16. PMID 7741020 DOI: 10.1016/S0065-2660(08)60201-1 |
0.324 |
|
| 1995 |
Yovandich J, O'Malley B, Sikes M, Ledley FD. Gene transfer to synovial cells by intra-articular administration of plasmid DNA Human Gene Therapy. 6: 603-610. PMID 7578397 DOI: 10.1089/Hum.1995.6.5-603 |
0.754 |
|
| 1995 |
Ledley FD. Editorial: When is a gene an investigational drug? Expert Opinion On Investigational Drugs. 4: 781-782. DOI: 10.1517/13543784.4.9.781 |
0.307 |
|
| 1994 |
Ledley FD. Designing clinical trials of somatic gene therapy. Annals of the New York Academy of Sciences. 716: 283-92; discussion 2. PMID 8024200 DOI: 10.1111/J.1749-6632.1994.Tb21719.X |
0.309 |
|
| 1994 |
Sikes ML, O'Malley BW, Finegold MJ, Ledley FD. In vivo gene transfer into rabbit thyroid follicular cells by direct DNA injection Human Gene Therapy. 5: 837-844. PMID 7981308 DOI: 10.1089/Hum.1994.5.7-837 |
0.697 |
|
| 1994 |
O'Malley BW, Adams RM, Sikes ML, Ledley FD. Gene transfer into human thyroid follicular cells. The Laryngoscope. 104: 1330-6. PMID 7968161 DOI: 10.1288/00005537-199411000-00004 |
0.721 |
|
| 1994 |
Ledley FD. Therapeutic promise of molecular genetics. The Journal of Investigative Dermatology. 103: 2S-5S. PMID 7963681 DOI: 10.1038/Jid.1994.2 |
0.32 |
|
| 1994 |
Ledley TS, Ledley FD. Multicompartment, numerical model of cellular events in the pharmacokinetics of gene therapies. Human Gene Therapy. 5: 679-91. PMID 7948130 DOI: 10.1089/Hum.1994.5.6-679 |
0.375 |
|
| 1994 |
Qureshi AA, Crane AM, Matiaszuk NV, Rezvani I, Ledley FD, Rosenblatt DS. Cloning and expression of mutations demonstrating intragenic complementation in mut0 methylmalonic aciduria. The Journal of Clinical Investigation. 93: 1812-9. PMID 7909321 DOI: 10.1172/Jci117166 |
0.318 |
|
| 1994 |
Stankovics J, Crane AM, Andrews E, Wu CH, Wu GY, Ledley FD. Overexpression of human methylmalonyl CoA mutase in mice after in vivo gene transfer with asialoglycoprotein/polylysine/DNA complexes. Human Gene Therapy. 5: 1095-104. PMID 7833369 DOI: 10.1089/Hum.1994.5.9-1095 |
0.366 |
|
| 1994 |
Ledley FD. Non-viral gene therapy. Current Opinion in Biotechnology. 5: 626-36. PMID 7765746 DOI: 10.1016/0958-1669(94)90085-X |
0.386 |
|
| 1994 |
Ledley FD. Development in Somatic Gene Therapy Expert Opinion On Investigational Drugs. 3: 913-921. DOI: 10.1517/13543784.3.9.913 |
0.37 |
|
| 1993 |
O'Malley BW, Adams RM, Sikes ML, Sawada T, Ledley FD. Retrovirus-mediated gene transfer into canine thyroid using an ex vivo strategy. Human Gene Therapy. 4: 171-8. PMID 8494926 DOI: 10.1089/Hum.1993.4.2-171 |
0.703 |
|
| 1993 |
Cholin S, Tonoki H, Hansen TN, Ledley FD. Expression of recombinant human glutathione reductase in eukaryotic cells after DNA-mediated gene transfer. Biochemical Medicine and Metabolic Biology. 49: 108-13. PMID 8439445 DOI: 10.1006/Bmmb.1993.1012 |
0.402 |
|
| 1993 |
O'Malley BW, Finegold MJ, Ledley FD. Autologous, orthotopic thyroid follicular cell transplantation: a surgical component of ex vivo somatic gene therapy. Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. 108: 51-62. PMID 8437874 DOI: 10.1177/019459989310800107 |
0.351 |
|
| 1993 |
Stankovics J, Ledley FD. Cloning of functional alpha propionyl CoA carboxylase and correction of enzyme deficiency in pccA fibroblasts. American Journal of Human Genetics. 52: 144-51. PMID 8434582 |
0.305 |
|
| 1993 |
O'Malley BW, Ledley FD. DNA- and viral-mediated gene transfer in follicular cells: progress toward gene therapy of the thyroid. The Laryngoscope. 103: 1084-92. PMID 8412442 DOI: 10.1288/00005537-199310000-00002 |
0.432 |
|
| 1993 |
O'Malley BW, Ledley FD. Somatic gene therapy. Methods for the present and future. Archives of Otolaryngology--Head & Neck Surgery. 119: 1100-7. PMID 8398061 DOI: 10.1001/Archotol.1993.01880220044007 |
0.414 |
|
| 1993 |
Ledley FD, Adams RM, Soriano HE, Darlington G, Finegold M, Lanford R, Carey D, Lewis D, Baley PA, Rothenberg S. Development of a clinical protocol for hepatic gene transfer: lessons learned in preclinical studies. Pediatric Research. 33: 313-20. PMID 8386832 DOI: 10.1203/00006450-199304000-00001 |
0.386 |
|
| 1993 |
O'Malley BW, Ledley FD. Somatic gene therapy in otolaryngology-head and neck surgery. Archives of Otolaryngology--Head & Neck Surgery. 119: 1191-7. PMID 8217078 DOI: 10.1001/Archotol.1993.01880230033006 |
0.351 |
|
| 1993 |
Wilkemeyer MF, Andrews ER, Ledley FD. Genomic structure of murine methylmalonyl-CoA mutase: evidence for genetic and epigenetic mechanisms determining enzyme activity. The Biochemical Journal. 296: 663-70. PMID 7904153 DOI: 10.1042/Bj2960663 |
0.321 |
|
| 1993 |
Andrews E, Jansen R, Crane AM, Cholin S, McDonnell D, Ledley FD. Expression of recombinant human methylmalonyl-CoA mutase: in primary mut fibroblasts and Saccharomyces cerevisiae. Biochemical Medicine and Metabolic Biology. 50: 135-44. PMID 7903149 DOI: 10.1006/Bmmb.1993.1055 |
0.379 |
|
| 1993 |
Cholin S, Tonoki H, Hansen T, Ledley F. Expression of Recombinant Human Glutathione Reductase in Eukaryotic Cells after DNA-Mediated Gene Transfer Biochemical Medicine and Metabolic Biology. 49: 108-113. DOI: 10.1006/BMMB.1993.1012 |
0.302 |
|
| 1992 |
Ledley FD. Somatic gene therapy in gastroenterology: approaches and applications. Journal of Pediatric Gastroenterology and Nutrition. 14: 328-37. PMID 1619540 DOI: 10.1097/00005176-199204000-00017 |
0.409 |
|
| 1992 |
O'Malley BW, Sikes ML, Adams RM, Finegold MJ, Ledley FD. Somatic gene therapy targeted to the thyroid: viral-mediated gene transfer in animal models. Transplantation Proceedings. 24: 2973-4. PMID 1466018 |
0.678 |
|
| 1992 |
Sawada T, Ledley FD. Correction of methylmalonyl-CoA mutase deficiency in Mut0 fibroblasts and constitution of gene expression in primary human hepatocytes by retroviral-mediated gene transfer. Somatic Cell and Molecular Genetics. 18: 507-16. PMID 1363156 DOI: 10.1007/Bf01232647 |
0.451 |
|
| 1992 |
Wilkemeyer M, Stankovics J, Foy T, Ledley FD. Propionate metabolism in cultured human cells after overexpression of recombinant methylmalonyl CoA mutase: implications for somatic gene therapy. Somatic Cell and Molecular Genetics. 18: 493-505. PMID 1363155 DOI: 10.1007/Bf01232646 |
0.767 |
|
| 1992 |
Crane AM, Jansen R, Andrews ER, Ledley FD. Cloning and expression of a mutant methylmalonyl coenzyme A mutase with altered cobalamin affinity that causes mut- methylmalonic aciduria. The Journal of Clinical Investigation. 89: 385-91. PMID 1346616 DOI: 10.1172/Jci115597 |
0.367 |
|
| 1992 |
Adams RM, Soriano HE, Wang M, Darlington G, Steffen D, Ledley FD. Transduction of primary human hepatocytes with amphotropic and xenotropic retroviral vectors. Proceedings of the National Academy of Sciences of the United States of America. 89: 8981-5. PMID 1329086 DOI: 10.1073/Pnas.89.19.8981 |
0.391 |
|
| 1991 |
Ponder KP, Gupta S, Leland F, Darlington G, Finegold M, DeMayo J, Ledley FD, Chowdhury JR, Woo SL. Mouse hepatocytes migrate to liver parenchyma and function indefinitely after intrasplenic transplantation. Proceedings of the National Academy of Sciences of the United States of America. 88: 1217-21. PMID 1899924 DOI: 10.1073/Pnas.88.4.1217 |
0.519 |
|
| 1991 |
Ledley FD. Clinical considerations in the design of protocols for somatic gene therapy. Human Gene Therapy. 2: 77-83. PMID 1863643 DOI: 10.1089/Hum.1991.2.1-77 |
0.359 |
|
| 1991 |
Wilkemeyer MF, Crane AM, Ledley FD. Differential diagnosis of mut and cbl methylmalonic aciduria by DNA-mediated gene transfer in primary fibroblasts. The Journal of Clinical Investigation. 87: 915-8. PMID 1671869 DOI: 10.1172/Jci115098 |
0.407 |
|
| 1991 |
Raff ML, Crane AM, Jansen R, Ledley FD, Rosenblatt DS. Genetic characterization of a MUT locus mutation discriminating heterogeneity in mut0 and mut- methylmalonic aciduria by interallelic complementation. The Journal of Clinical Investigation. 87: 203-7. PMID 1670635 DOI: 10.1172/Jci114972 |
0.329 |
|
| 1990 |
Ledley FD, Grenett HE, Dunbar BS, Woo SL. Mouse phenylalanine hydroxylase. Homology and divergence from human phenylalanine hydroxylase. The Biochemical Journal. 267: 399-405. PMID 2334400 DOI: 10.1042/Bj2670399 |
0.55 |
|
| 1990 |
Sifers RN, Ledley FD, Reed-Fourquet L, Ledbetter DH, Ledbetter SA, Woo SL. Complete cDNA sequence and chromosomal localization of mouse alpha 1-antitrypsin. Genomics. 6: 100-4. PMID 2303252 DOI: 10.1016/0888-7543(90)90453-2 |
0.525 |
|
| 1990 |
Ledley FD. Clinical application of somatic gene therapy in inborn errors of metabolism. Journal of Inherited Metabolic Disease. 13: 597-616. PMID 2122123 DOI: 10.1007/Bf01799515 |
0.389 |
|
| 1990 |
Nham SU, Wilkemeyer MF, Ledley FD. Structure of the human methylmalonyl-CoA mutase (MUT) locus. Genomics. 8: 710-6. PMID 1980486 DOI: 10.1016/0888-7543(90)90259-W |
0.37 |
|
| 1990 |
Wilkemeyer MF, Crane AM, Ledley FD. Primary structure and activity of mouse methylmalonyl-CoA mutase. The Biochemical Journal. 271: 449-55. PMID 1978672 DOI: 10.1042/Bj2710449 |
0.363 |
|
| 1990 |
Ledley FD. Perspectives on methylmalonic acidemia resulting from molecular cloning of methylmalonyl CoA mutase. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 12: 335-40. PMID 1975493 DOI: 10.1002/Bies.950120706 |
0.377 |
|
| 1990 |
Threadgill DW, Wilkemeyer M, Womack JE, Ledley FD. Localization of the murine methylmalonyl CoA mutase (Mut) locus on chromosome 17 by in situ hybridization Cytogenetic and Genome Research. 53: 112-114. PMID 1973376 DOI: 10.1159/000132907 |
0.744 |
|
| 1990 |
Sertić J, Vincek V, Ledley FD, Figueroa F, Klein J. Mapping of the L-methylmalonyl-CoA mutase gene to mouse chromosome 17. Genomics. 6: 560-4. PMID 1970332 DOI: 10.1016/0888-7543(90)90487-F |
0.348 |
|
| 1990 |
Ledley FD, Jansen R, Nham SU, Fenton WA, Rosenberg LE. Mutation eliminating mitochondrial leader sequence of methylmalonyl-CoA mutase causes muto methylmalonic acidemia Proceedings of the National Academy of Sciences of the United States of America. 87: 3147-3150. PMID 1970180 DOI: 10.1073/Pnas.87.8.3147 |
0.303 |
|
| 1989 |
Cheng SV, Martin GR, Nadeau JH, Haines JL, Bucan M, Kozak CA, MacDonald ME, Lockyer JL, Ledley FD, Woo SL. Synteny on mouse chromosome 5 of homologs for human DNA loci linked to the Huntington disease gene. Genomics. 4: 419-26. PMID 2523855 DOI: 10.1016/0888-7543(89)90349-2 |
0.566 |
|
| 1988 |
Ledley FD, Grenett HE, Bartos DP, Woo SL. Retroviral mediated transfer and expression of human alpha 1-antitrypsin in cultured cells. Gene. 61: 113-8. PMID 3502102 DOI: 10.1016/0378-1119(87)90370-2 |
0.561 |
|
| 1988 |
Ledley FD, Ledbetter SA, Ledbetter DH, Woo SL. Localization of mouse phenylalanine hydroxylase locus on chromosome 10. Cytogenetics and Cell Genetics. 47: 125-6. PMID 3378451 DOI: 10.1159/000132528 |
0.511 |
|
| 1988 |
McDonald JD, Cotton RG, Jennings I, Ledley FD, Woo SL, Bode VC. Biochemical defect of the hph-1 mouse mutant is a deficiency in GTP-cyclohydrolase activity. Journal of Neurochemistry. 50: 655-7. PMID 3335865 DOI: 10.1111/J.1471-4159.1988.Tb02961.X |
0.429 |
|
| 1988 |
Peng H, Armentano D, MacKenzie-Graham L, Shen RF, Darlington G, Ledley FD, Woo SL. Retroviral-mediated gene transfer and expression of human phenylalanine hydroxylase in primary mouse hepatocytes. Proceedings of the National Academy of Sciences of the United States of America. 85: 8146-50. PMID 3186716 DOI: 10.1073/Pnas.85.21.8146 |
0.603 |
|
| 1988 |
Zoghbi HY, O'Brien WE, Ledley FD. Linkage relationships of the human methylmalonyl CoA mutase to the HLA and D6S4 loci on chromosome 6. Genomics. 3: 396-8. PMID 2907507 DOI: 10.1016/0888-7543(88)90135-8 |
0.321 |
|
| 1988 |
Ledley FD, Koch R, Jew K, Beaudet A, O'Brien WE, Bartos DP, Woo SL. Phenylalanine hydroxylase expression in liver of a fetus with phenylketonuria. The Journal of Pediatrics. 113: 463-8. PMID 2900886 DOI: 10.1016/S0022-3476(88)80629-2 |
0.496 |
|
| 1988 |
Ledley FD, Lumetta M, Nguyen PN, Kolhouse JF, Allen RH. Molecular cloning of L-methylmalonyl-CoA mutase: Gene transfer and analysis of mut cell lines Proceedings of the National Academy of Sciences of the United States of America. 85: 3518-3521. PMID 2453061 DOI: 10.1073/Pnas.85.10.3518 |
0.43 |
|
| 1987 |
Ledley FD. Somatic gene therapy for human disease: a problem of eugenics? Trends in Genetics : Tig. 3: 112-5. PMID 11652998 DOI: 10.1016/0168-9525(87)90195-8 |
0.359 |
|
| 1987 |
Marvit J, DiLella AG, Brayton K, Ledley FD, Robson KJ, Woo SL. GT to AT transition at a splice donor site causes skipping of the preceding exon in phenylketonuria. Nucleic Acids Research. 15: 5613-28. PMID 3615198 DOI: 10.1093/Nar/15.14.5613 |
0.582 |
|
| 1987 |
Bao JJ, Sifers RN, Kidd VJ, Ledley FD, Woo SLC. Molecular evolution of serpins: Homologous structure of the human α1-antichymotrypsin and α1-antitrypsin genes Biochemistry. 26: 7755-7759. PMID 3501319 DOI: 10.1021/Bi00398A033 |
0.354 |
|
| 1987 |
Grenett HE, Ledley FD, Reed LL, Woo SL. Full-length cDNA for rabbit tryptophan hydroxylase: functional domains and evolution of aromatic amino acid hydroxylases Proceedings of the National Academy of Sciences of the United States of America. 84: 5530-5534. PMID 3475690 DOI: 10.1073/Pnas.84.16.5530 |
0.516 |
|
| 1987 |
Ledley FD, Darlington GJ, Hahn T, Woo SL. Retroviral gene transfer into primary hepatocytes: implications for genetic therapy of liver-specific functions Proceedings of the National Academy of Sciences of the United States of America. 84: 5335-5339. PMID 3474659 DOI: 10.1073/Pnas.84.15.5335 |
0.587 |
|
| 1987 |
Ledley FD, Hahn T, Woo SL. Selection for phenylalanine hydroxylase activity in cells transformed with recombinant retroviruses. Somatic Cell and Molecular Genetics. 13: 145-54. PMID 3470952 DOI: 10.1007/Bf01534694 |
0.562 |
|
| 1987 |
Ledley FD. Somatic gene therapy for human disease: background and prospects. Part II. The Journal of Pediatrics. 110: 167-74. PMID 3100752 DOI: 10.1016/S0022-3476(87)80148-8 |
0.35 |
|
| 1987 |
Lockyer J, Cook RG, Milstien S, Kaufman S, Woo SL, Ledley FD. Structure and expression of human dihydropteridine reductase. Proceedings of the National Academy of Sciences of the United States of America. 84: 3329-33. PMID 3033643 DOI: 10.1073/Pnas.84.10.3329 |
0.541 |
|
| 1987 |
Ledley FD, Woo SL. P-chlorophenylalanine does not inhibit production of recombinant human phenylalanine hydroxylase in NIH3T3 cells or E. coli. Biochemical and Biophysical Research Communications. 142: 302-8. PMID 2949745 DOI: 10.1016/0006-291X(87)90273-7 |
0.536 |
|
| 1987 |
Woo SL, DiLella AG, Marvit J, Ledley FD. Molecular basis of phenylketonuria and recombinant DNA strategies for its therapy. Enzyme. 38: 207-13. PMID 2894302 DOI: 10.1159/000469206 |
0.313 |
|
| 1987 |
Güttler F, DiLella AG, Ledley FD, Lidsky AS, Kvok SC, Marvit J, Woo SL. Molecular biology of phenylketonuria. European Journal of Pediatrics. 146: A5-11. PMID 2891509 DOI: 10.1007/Bf00442048 |
0.438 |
|
| 1987 |
Ledley FD, Grenett HE, Bartos DP, van Tuinen P, Ledbetter DH, Woo SL. Assignment of human tryptophan hydroxylase locus to chromosome 11: gene duplication and translocation in evolution of aromatic amino acid hydroxylases. Somatic Cell and Molecular Genetics. 13: 575-80. PMID 2889273 DOI: 10.1007/Bf01534499 |
0.567 |
|
| 1987 |
MacDonald ME, Anderson MA, Lockyer JL, Milstien S, Hobbs WJ, Faryniarz AG, Kaufman S, Ledley FD, Woo SL, Gusella JF. Physical and genetic localization of quinonoid dihydropteridine reductase gene (QDPR) on short arm of chromosome 4. Somatic Cell and Molecular Genetics. 13: 569-74. PMID 2889272 DOI: 10.1007/Bf01534498 |
0.592 |
|
| 1987 |
Woo SL, DiLella AG, Marvit J, Ledley FD. Molecular basis of phenylketonuria and potential somatic gene therapy. Cold Spring Harbor Symposia On Quantitative Biology. 395-401. PMID 2884065 DOI: 10.1101/Sqb.1986.051.01.047 |
0.547 |
|
| 1987 |
Güttler F, Ledley FD, Lidsky AS, DiLella AG, Sullivan SE, Woo SL. Correlation between polymorphic DNA haplotypes at phenylalanine hydroxylase locus and clinical phenotypes of phenylketonuria. The Journal of Pediatrics. 110: 68-71. PMID 2878985 DOI: 10.1016/S0022-3476(87)80290-1 |
0.492 |
|
| 1987 |
Ledley FD, Lockyer J, Kaufman S, Milstein S, Woo SLC. Dihydropteridine Reductase Deficiency: Cloning Of The Dihydropteridine Reductase Gene, Analysis Of Mutant Cells, And Prospects For Genetic Therapy Pediatric Research. 21: 344-344. DOI: 10.1203/00006450-198704010-01059 |
0.468 |
|
| 1987 |
Ledley FD, Darlington G, Hahn T, Woo SLC, Beaudet A. Gene Transfer Into Primary Hepatocytes For Somatic Gene Therapy Pediatric Research. 21: 291-291. DOI: 10.1203/00006450-198704010-00745 |
0.435 |
|
| 1986 |
Ledley FD, Levy HL, Woo SL. Molecular analysis of the inheritance of phenylketonuria and mild hyperphenylalaninemia in families with both disorders. The New England Journal of Medicine. 314: 1276-80. PMID 3702929 DOI: 10.1056/Nejm198605153142002 |
0.5 |
|
| 1986 |
Ledley FD, Grenett HE, McGinnis-Shelnutt M, Woo SL. Retroviral-mediated gene transfer of human phenylalanine hydroxylase into NIH 3T3 and hepatoma cells. Proceedings of the National Academy of Sciences of the United States of America. 83: 409-13. PMID 3455778 DOI: 10.1073/Pnas.83.2.409 |
0.588 |
|
| 1986 |
Ledley FD, Woo SL. Molecular basis of alpha 1-antitrypsin deficiency and its potential therapy by gene transfer. Journal of Inherited Metabolic Disease. 9: 85-91. PMID 3097419 DOI: 10.1007/Bf01800861 |
0.571 |
|
| 1986 |
DiLella AG, Kwok SC, Ledley FD, Marvit J, Woo SL. Molecular structure and polymorphic map of the human phenylalanine hydroxylase gene. Biochemistry. 25: 743-9. PMID 3008810 DOI: 10.1021/Bi00352A001 |
0.591 |
|
| 1985 |
Ledley FD, Grenett HE, DiLella AG, Kwok SC, Woo SL. Gene transfer and expression of human phenylalanine hydroxylase. Science (New York, N.Y.). 228: 77-9. PMID 3856322 DOI: 10.1126/Science.3856322 |
0.601 |
|
| 1985 |
Kwok SC, Ledley FD, DiLella AG, Robson KJ, Woo SL. Nucleotide sequence of a full-length complementary DNA clone and amino acid sequence of human phenylalanine hydroxylase. Biochemistry. 24: 556-61. PMID 2986678 DOI: 10.1021/Bi00324A002 |
0.529 |
|
| 1985 |
DiLella AG, Ledley FD, Rey F, Munnich A, Woo SL. Detection of phenylalanine hydroxylase messenger RNA in liver biopsy samples from patients with phenylketonuria. Lancet (London, England). 1: 160-1. PMID 2857230 DOI: 10.1016/S0140-6736(85)91925-7 |
0.451 |
|
| 1985 |
Ledley FD, DiLella AG, Kwok SC, Woo SL. Homology between phenylalanine and tyrosine hydroxylases reveals common structural and functional domains. Biochemistry. 24: 3389-94. PMID 2412578 DOI: 10.1021/Bi00335A001 |
0.518 |
|
| 1985 |
Ledley FD, Levy HL, Lidsky AS, Woo SLC. 1225 Pku And Mild Hyperphenylalaninemia (Mhp) In Siblings: Biochemical Characterization And Molecular Rflp Analysis Of The Phenylalanine Hydroxylase (Pah) Gene Pediatric Research. 19: 315-315. DOI: 10.1203/00006450-198504000-01255 |
0.353 |
|
| 1985 |
Ledley FD, Grenett HE, Woo SLC. 1224 Viral Mediated Gene Transfer Of Recombinant Human Phenylalanine Hydroxylase (Pah) Using Retroviruses Pediatric Research. 19: 314-314. DOI: 10.1203/00006450-198504000-01254 |
0.411 |
|
| 1985 |
Ledley FD. Book ReviewClinical Atlas of Human Chromosomes New England Journal of Medicine. 312: 129-130. DOI: 10.1056/Nejm198501103120234 |
0.302 |
|
| 1985 |
Ledley FD, DiLella AG, Woo SLC. Molecular biology of phenylalanine hydroxylase and phenylketonuria Trends in Genetics. 1: 309-313. DOI: 10.1016/0168-9525(85)90121-0 |
0.422 |
|
| 1984 |
Wang JY, Ledley F, Goff S, Lee R, Groner Y, Baltimore D. The mouse c-abl locus: molecular cloning and characterization. Cell. 36: 349-56. PMID 6319018 DOI: 10.1016/0092-8674(84)90228-9 |
0.692 |
|
| 1980 |
Kohn LD, Consiglio E, DeWolf MJ, Grollman EF, Ledley FD, Lee G, Morris NP. Thyrotropin receptors and gangliosides. Advances in Experimental Medicine and Biology. 125: 487-503. PMID 6244725 DOI: 10.1007/978-1-4684-7844-0_43 |
0.484 |
|
| 1978 |
Habig WH, Grollman EF, Ledley FD, Meldolesi MF, Aloj SM, Hardegree MC, Kohn LD. Tetanus toxin interactions with the thyroid: decreased toxin binding to membranes from a thyroid tumor with a thyrotropin receptor defect and in vivo stimulation of thyroid function. Endocrinology. 102: 844-51. PMID 217603 DOI: 10.1210/Endo-102-3-844 |
0.501 |
|
| 1977 |
Meldolesi MF, Fishman PH, Aloj SM, Ledley FD, Lee G, Bradley RM, Bradley RM, Brady RO, Kohn LD. Separation of the glycoprotein and ganglioside components of thyrotropin receptor activity in plasma membranes. Biochemical and Biophysical Research Communications. 75: 581-8. PMID 193492 DOI: 10.1016/0006-291X(77)91512-1 |
0.486 |
|
| 1976 |
Ledley FD, Mullin BR, Lee G, Aloj SM, Fishman PH, Hunt LT, Dayhoff MO, Kohn LD. Sequence similarity between cholera toxin and glycoprotein hormones: implications for structure activity relationship and mechanism of action. Biochemical and Biophysical Research Communications. 69: 852-9. PMID 1275921 DOI: 10.1016/0006-291X(76)90452-6 |
0.527 |
|
| 1976 |
Mullin BR, Lee G, Ledley FD, Winland RJ, Kohn LD. Thyrotropin interactions with human fat cell membrane preparations and the finding of soluble thyrotropin binding component. Biochemical and Biophysical Research Communications. 69: 55-62. PMID 177020 DOI: 10.1016/S0006-291X(76)80271-9 |
0.506 |
|
| 1976 |
Mullin BR, Fishman PH, Lee G, Aloj SM, Ledley FD, Winand RJ, Kohn LD, Brady RO. Thyrotropin-ganglioside interactions and their relationship to the structure and function of thyrotropin receptors. Proceedings of the National Academy of Sciences of the United States of America. 73: 842-6. PMID 176657 DOI: 10.1073/Pnas.73.3.842 |
0.507 |
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