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Vadim Molodtsov - Publications

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22 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Molodtsov V, Wang C, Kaelber JT, Blaha G, Ebright RH. Structural basis of RfaH-mediated transcription-translation coupling. Biorxiv : the Preprint Server For Biology. PMID 37986937 DOI: 10.1101/2023.11.05.565726  0.609
2023 Wang C, Molodtsov V, Sanders TJ, Marshall CJ, Firlar E, Kaelber JT, Santangelo TJ, Ebright RH. Structural basis of archaeal FttA-dependent transcription termination. Biorxiv : the Preprint Server For Biology. PMID 37609354 DOI: 10.1101/2023.08.09.552649  0.662
2023 Molodtsov V, Wang C, Firlar E, Kaelber JT, Ebright RH. Structural basis of Rho-dependent transcription termination. Nature. PMID 36697824 DOI: 10.1038/s41586-022-05658-1  0.656
2022 Lan T, Ganapathy US, Sharma S, Ahn YM, Zimmerman M, Molodtsov V, Hegde P, Gengenbacher M, Ebright RH, Dartois V, Freundlich JS, Dick T, Aldrich CC. Redesign of Rifamycin Antibiotics to Overcome ADP-Ribosylation-Mediated Resistance. Angewandte Chemie (International Ed. in English). e202211498. PMID 36222275 DOI: 10.1002/anie.202211498  0.497
2022 Pukhrambam C, Molodtsov V, Kooshkbaghi M, Tareen A, Vu H, Skalenko KS, Su M, Yin Z, Winkelman JT, Kinney JB, Ebright RH, Nickels BE. Structural and mechanistic basis of σ-dependent transcriptional pausing. Proceedings of the National Academy of Sciences of the United States of America. 119: e2201301119. PMID 35653571 DOI: 10.1073/pnas.2201301119  0.547
2022 Ma Z, He S, Yuan Y, Zhuang Z, Liu Y, Wang H, Chen J, Xu X, Ding C, Molodtsov V, Lin W, Robertson GT, Weiss WJ, Pulse M, Nguyen P, et al. Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. Journal of Medicinal Chemistry. PMID 35175750 DOI: 10.1021/acs.jmedchem.1c02045  0.577
2021 Qayyum MZ, Molodtsov V, Renda A, Murakami KS. Structural basis of RNA polymerase recycling by the Swi2/Snf2 family of ATPase RapA in Escherichia coli. The Journal of Biological Chemistry. 297: 101404. PMID 34774797 DOI: 10.1016/j.jbc.2021.101404  0.454
2020 Haupenthal J, Kautz Y, Elgaher WAM, P Auml Tzold L, Roehrig T, Laschke MW, Tschernig T, Hirsch AKH, Molodtsov V, Murakami KS, Hartmann RW, Bischoff M. Evaluation of Bacterial RNA Polymerase Inhibitors in a Staphylococcus aureus-based Wound-Infection Model in SKH1 Mice. Acs Infectious Diseases. PMID 32886885 DOI: 10.1021/Acsinfecdis.0C00034  0.414
2020 Wang C, Molodtsov V, Firlar E, Kaelber JT, Blaha G, Su M, Ebright RH. Structural basis of transcription-translation coupling. Science (New York, N.Y.). PMID 32820061 DOI: 10.1126/Science.Abb5317  0.637
2020 Li L, Molodtsov V, Lin W, Ebright RH, Zhang Y. RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proceedings of the National Academy of Sciences of the United States of America. PMID 32127479 DOI: 10.2210/Pdb6Kql/Pdb  0.682
2018 Mosaei H, Molodtsov V, Kepplinger B, Harbottle J, Moon CW, Jeeves RE, Ceccaroni L, Shin Y, Morton-Laing S, Marrs ECL, Wills C, Clegg W, Yuzenkova Y, Perry JD, Bacon J, et al. Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis. Molecular Cell. PMID 30244835 DOI: 10.1016/J.Molcel.2018.08.028  0.513
2018 Bruhn-Olszewska B, Molodtsov V, Sobala M, Dylewski M, Murakami KS, Cashel M, Potrykus K. Structure-function comparisons of (p)ppApp vs (p)ppGpp for Escherichia coli RNA polymerase binding sites and for rrnB P1 promoter regulatory responses in vitro. Biochimica Et Biophysica Acta. 1861: 731-742. PMID 30012465 DOI: 10.1016/J.Bbagrm.2018.07.005  0.437
2018 Molodtsov V, Murakami KS. Minimalism and functionality: Structural lessons from the heterodimeric N4 bacteriophageRNA polymerase II. The Journal of Biological Chemistry. PMID 29991593 DOI: 10.1074/Jbc.Ra118.003447  0.548
2018 Molodtsov V, Sineva E, Zhang L, Huang X, Cashel M, Ades SE, Murakami KS. Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA. Molecular Cell. PMID 29478808 DOI: 10.1016/J.Molcel.2018.01.035  0.594
2017 Murakami KS, Shin Y, Turnbough CL, Molodtsov V. X-ray crystal structure of a reiterative transcription complex reveals an atypical RNA extension pathway. Proceedings of the National Academy of Sciences of the United States of America. PMID 28652344 DOI: 10.1073/Pnas.1702741114  0.611
2016 Scharf NT, Molodtsov V, Kontos A, Murakami KS, Garcia GA. Novel Chemical Scaffolds for Inhibition of Rifamycin-Resistant RNA Polymerase Discovered from High-Throughput Screening. Journal of Biomolecular Screening. 1087057116679994. PMID 28071153 DOI: 10.1177/1087057116679994  0.32
2016 Scharf NT, Molodtsov V, Kontos A, Murakami KS, Garcia GA. Novel Chemical Scaffolds for Inhibition of Rifamycin-Resistant RNA Polymerase Discovered from High-Throughput Screening. Journal of Biomolecular Screening. 2472555216679994. PMID 28027449 DOI: 10.1177/1087057116679994  0.41
2016 Molodtsov V, Scharf NT, Stefan MA, Garcia GA, Murakami KS. Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis. Molecular Microbiology. PMID 28009073 DOI: 10.1111/Mmi.13606  0.399
2015 Molodtsov V, Fleming PR, Eyermann CJ, Ferguson AD, Foulk MA, McKinney DC, Masse CE, Buurman ET, Murakami KS. X-ray crystal structures of Escherichia coli RNA polymerase with switch region binding inhibitors enable rational design of squaramides with an improved fraction unbound to human plasma protein. Journal of Medicinal Chemistry. 58: 3156-71. PMID 25798859 DOI: 10.1021/Acs.Jmedchem.5B00050  0.527
2014 Molodtsov V, Anikin M, McAllister WT. The presence of an RNA:DNA hybrid that is prone to slippage promotes termination by T7 RNA polymerase. Journal of Molecular Biology. 426: 3095-3107. PMID 24976131 DOI: 10.1016/J.Jmb.2014.06.012  0.556
2014 Basu RS, Warner BA, Molodtsov V, Pupov D, Esyunina D, Fernández-Tornero C, Kulbachinskiy A, Murakami KS. Structural basis of transcription initiation by bacterial RNA polymerase holoenzyme. The Journal of Biological Chemistry. 289: 24549-59. PMID 24973216 DOI: 10.1074/Jbc.M114.584037  0.628
2013 Molodtsov V, Nawarathne IN, Scharf NT, Kirchhoff PD, Showalter HD, Garcia GA, Murakami KS. X-ray crystal structures of the Escherichia coli RNA polymerase in complex with benzoxazinorifamycins. Journal of Medicinal Chemistry. 56: 4758-63. PMID 23679862 DOI: 10.1021/Jm4004889  0.596
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