| Year |
Citation |
Score |
| 2020 |
Alirezaei M, Flynn CT, Garcia SD, Kimura T, Whitton JL. A food-responsive switch modulates TFEB and autophagy, and determines susceptibility to coxsackievirus infection and pancreatitis. Autophagy. 1-18. PMID 32019403 DOI: 10.1080/15548627.2020.1720425 |
0.301 |
|
| 2019 |
Kimura T, Flynn CT, Alirezaei M, Sen GC, Whitton JL. Biphasic and cardiomyocyte-specific IFIT activity protects cardiomyocytes from enteroviral infection. Plos Pathogens. 15: e1007674. PMID 30958867 DOI: 10.1371/Journal.Ppat.1007674 |
0.445 |
|
| 2017 |
Flynn CT, Kimura T, Frimpong-Boateng K, Harkins S, Whitton JL. Immunological and pathological consequences of coxsackievirus RNA persistence in the heart. Virology. 512: 104-112. PMID 28950225 DOI: 10.1016/J.Virol.2017.09.017 |
0.309 |
|
| 2016 |
Hosking MP, Flynn CT, Whitton JL. Type I IFN Signaling Is Dispensable during Secondary Viral Infection. Plos Pathogens. 12: e1005861. PMID 27580079 DOI: 10.1371/Journal.Ppat.1005861 |
0.45 |
|
| 2016 |
Hosking MP, Flynn CT, Whitton JL. TCR independent suppression of CD8(+) T cell cytokine production mediated by IFNγ in vivo. Virology. 498: 69-81. PMID 27564543 DOI: 10.1016/J.Virol.2016.08.003 |
0.446 |
|
| 2016 |
Harkins S, Whitton JL. Chromosomal mapping of the αMHC-MerCreMer transgene in mice reveals a large genomic deletion. Transgenic Research. PMID 27165291 DOI: 10.1007/S11248-016-9960-6 |
0.301 |
|
| 2015 |
Alirezaei M, Flynn CT, Wood MR, Harkins S, Whitton JL. Coxsackievirus can exploit LC3 in both autophagy-dependent and -independent manners in vivo. Autophagy. 0. PMID 26090585 DOI: 10.1080/15548627.2015.1063769 |
0.33 |
|
| 2014 |
Hosking MP, Flynn CT, Whitton JL. Antigen-specific naive CD8+ T cells produce a single pulse of IFN-γ in vivo within hours of infection, but without antiviral effect. Journal of Immunology (Baltimore, Md. : 1950). 193: 1873-85. PMID 25015828 DOI: 10.4049/Jimmunol.1400348 |
0.465 |
|
| 2014 |
Robinson SM, Tsueng G, Sin J, Mangale V, Rahawi S, McIntyre LL, Williams W, Kha N, Cruz C, Hancock BM, Nguyen DP, Sayen MR, Hilton BJ, Doran KS, Segall AM, ... ... Whitton JL, et al. Coxsackievirus B exits the host cell in shed microvesicles displaying autophagosomal markers. Plos Pathogens. 10: e1004045. PMID 24722773 DOI: 10.1371/Journal.Ppat.1004045 |
0.399 |
|
| 2014 |
Althof N, Harkins S, Kemball CC, Flynn CT, Alirezaei M, Whitton JL. In vivo ablation of type I interferon receptor from cardiomyocytes delays coxsackieviral clearance and accelerates myocardial disease. Journal of Virology. 88: 5087-99. PMID 24574394 DOI: 10.1128/Jvi.00184-14 |
0.309 |
|
| 2013 |
Misumi I, Alirezaei M, Eam B, Su MA, Whitton JL, Whitmire JK. Differential T cell responses to residual viral antigen prolong CD4+ T cell contraction following the resolution of infection. Journal of Immunology (Baltimore, Md. : 1950). 191: 5655-68. PMID 24146043 DOI: 10.4049/Jimmunol.1301215 |
0.451 |
|
| 2013 |
Hosking MP, Flynn CT, Botten J, Whitton JL. CD8+ memory T cells appear exhausted within hours of acute virus infection. Journal of Immunology (Baltimore, Md. : 1950). 191: 4211-22. PMID 24026080 DOI: 10.4049/Jimmunol.1300920 |
0.459 |
|
| 2012 |
Alirezaei M, Flynn CT, Whitton JL. Interactions between enteroviruses and autophagy in vivo. Autophagy. 8: 973-5. PMID 22705981 DOI: 10.4161/Auto.20160 |
0.387 |
|
| 2012 |
Kemball CC, Flynn CT, Hosking MP, Botten J, Whitton JL. Wild-type coxsackievirus infection dramatically alters the abundance, heterogeneity, and immunostimulatory capacity of conventional dendritic cells in vivo. Virology. 429: 74-90. PMID 22551767 DOI: 10.1016/J.Virol.2012.04.005 |
0.459 |
|
| 2012 |
Alirezaei M, Flynn CT, Wood MR, Whitton JL. Pancreatic acinar cell-specific autophagy disruption reduces coxsackievirus replication and pathogenesis in vivo. Cell Host & Microbe. 11: 298-305. PMID 22423969 DOI: 10.1016/J.Chom.2012.01.014 |
0.355 |
|
| 2012 |
Ruller CM, Tabor-Godwin JM, Van Deren DA, Robinson SM, Maciejewski S, Gluhm S, Gilbert PE, An N, Gude NA, Sussman MA, Whitton JL, Feuer R. Neural stem cell depletion and CNS developmental defects after enteroviral infection. The American Journal of Pathology. 180: 1107-20. PMID 22214838 DOI: 10.1016/J.Ajpath.2011.11.016 |
0.406 |
|
| 2011 |
Moore CS, Milner R, Nishiyama A, Frausto RF, Serwanski DR, Pagarigan RR, Whitton JL, Miller RH, Crocker SJ. Astrocytic tissue inhibitor of metalloproteinase-1 (TIMP-1) promotes oligodendrocyte differentiation and enhances CNS myelination. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6247-54. PMID 21508247 DOI: 10.1523/Jneurosci.5474-10.2011 |
0.717 |
|
| 2011 |
Tsueng G, Tabor-Godwin JM, Gopal A, Ruller CM, Deline S, An N, Frausto RF, Milner R, Crocker SJ, Whitton JL, Feuer R. Coxsackievirus preferentially replicates and induces cytopathic effects in undifferentiated neural progenitor cells. Journal of Virology. 85: 5718-32. PMID 21471247 DOI: 10.1128/Jvi.02261-10 |
0.669 |
|
| 2011 |
Crocker SJ, Bajpai R, Moore CS, Frausto RF, Brown GD, Pagarigan RR, Whitton JL, Terskikh AV. Intravenous administration of human embryonic stem cell-derived neural precursor cells attenuates cuprizone-induced central nervous system (CNS) demyelination. Neuropathology and Applied Neurobiology. 37: 643-53. PMID 21276029 DOI: 10.1111/J.1365-2990.2011.01165.X |
0.715 |
|
| 2010 |
Kemball CC, Alirezaei M, Flynn CT, Wood MR, Harkins S, Kiosses WB, Whitton JL. Coxsackievirus infection induces autophagy-like vesicles and megaphagosomes in pancreatic acinar cells in vivo. Journal of Virology. 84: 12110-24. PMID 20861268 DOI: 10.1128/Jvi.01417-10 |
0.4 |
|
| 2010 |
Kemball CC, Alirezaei M, Whitton JL. Type B coxsackieviruses and their interactions with the innate and adaptive immune systems. Future Microbiology. 5: 1329-47. PMID 20860480 DOI: 10.2217/Fmb.10.101 |
0.403 |
|
| 2010 |
Botten J, Whitton JL, Barrowman P, Sidney J, Whitmire JK, Alexander J, Kotturi MF, Sette A, Buchmeier MJ. A multivalent vaccination strategy for the prevention of Old World arenavirus infection in humans. Journal of Virology. 84: 9947-56. PMID 20668086 DOI: 10.1128/Jvi.00672-10 |
0.503 |
|
| 2010 |
Tabor-Godwin JM, Ruller CM, Bagalso N, An N, Pagarigan RR, Harkins S, Gilbert PE, Kiosses WB, Gude NA, Cornell CT, Doran KS, Sussman MA, Whitton JL, Feuer R. A novel population of myeloid cells responding to coxsackievirus infection assists in the dissemination of virus within the neonatal CNS. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 8676-91. PMID 20573913 DOI: 10.1523/Jneurosci.1860-10.2010 |
0.432 |
|
| 2009 |
Kemball CC, Harkins S, Whitmire JK, Flynn CT, Feuer R, Whitton JL. Coxsackievirus B3 inhibits antigen presentation in vivo, exerting a profound and selective effect on the MHC class I pathway. Plos Pathogens. 5: e1000618. PMID 19834548 DOI: 10.1371/Journal.Ppat.1000618 |
0.478 |
|
| 2009 |
Feuer R, Ruller CM, An N, Tabor-Godwin JM, Rhoades RE, Maciejewski S, Pagarigan RR, Cornell CT, Crocker SJ, Kiosses WB, Pham-Mitchell N, Campbell IL, Whitton JL. Viral persistence and chronic immunopathology in the adult central nervous system following Coxsackievirus infection during the neonatal period. Journal of Virology. 83: 9356-69. PMID 19570873 DOI: 10.1128/Jvi.02382-07 |
0.709 |
|
| 2009 |
Whitmire JK, Eam B, Whitton JL. Mice deficient in stem cell antigen-1 (Sca1, Ly-6A/E) develop normal primary and memory CD4+ and CD8+ T-cell responses to virus infection. European Journal of Immunology. 39: 1494-504. PMID 19384870 DOI: 10.1002/Eji.200838959 |
0.446 |
|
| 2009 |
Alirezaei M, Fox HS, Flynn CT, Moore CS, Hebb AL, Frausto RF, Bhan V, Kiosses WB, Whitton JL, Robertson GS, Crocker SJ. Elevated ATG5 expression in autoimmune demyelination and multiple sclerosis. Autophagy. 5: 152-8. PMID 19066443 DOI: 10.4161/Auto.5.2.7348 |
0.752 |
|
| 2008 |
Krogstad P, Hammon R, Halnon N, Whitton JL. Fatal neonatal myocarditis caused by a recombinant human enterovirus-B variant. The Pediatric Infectious Disease Journal. 27: 668-9. PMID 18536618 DOI: 10.1097/Inf.0B013E31816B5D2A |
0.31 |
|
| 2008 |
Whitmire JK, Benning N, Eam B, Whitton JL. Increasing the CD4+ T cell precursor frequency leads to competition for IFN-gamma thereby degrading memory cell quantity and quality. Journal of Immunology (Baltimore, Md. : 1950). 180: 6777-85. PMID 18453598 DOI: 10.4049/Jimmunol.180.10.6777 |
0.412 |
|
| 2008 |
Crocker SJ, Frausto RF, Whitton JL, Milner R. A novel method to establish microglia-free astrocyte cultures: comparison of matrix metalloproteinase expression profiles in pure cultures of astrocytes and microglia. Glia. 56: 1187-98. PMID 18449943 DOI: 10.1002/Glia.20689 |
0.616 |
|
| 2008 |
Whitmire JK, Eam B, Whitton JL. Tentative T cells: memory cells are quick to respond, but slow to divide. Plos Pathogens. 4: e1000041. PMID 18404208 DOI: 10.1371/Journal.Ppat.1000041 |
0.406 |
|
| 2008 |
Kemball CC, Harkins S, Whitton JL. Enumeration and functional evaluation of virus-specific CD4+ and CD8+ T cells in lymphoid and peripheral sites of coxsackievirus B3 infection. Journal of Virology. 82: 4331-42. PMID 18305030 DOI: 10.1128/Jvi.02639-07 |
0.42 |
|
| 2007 |
Foster B, Prussin C, Liu F, Whitmire JK, Whitton JL. Detection of intracellular cytokines by flow cytometry. Current Protocols in Immunology / Edited by John E. Coligan ... [Et Al.]. Unit 6.24. PMID 18432993 DOI: 10.1002/0471142735.Im0624S78 |
0.376 |
|
| 2007 |
Crocker SJ, Frausto RF, Whitmire JK, Benning N, Milner R, Whitton JL. Amelioration of coxsackievirus B3-mediated myocarditis by inhibition of tissue inhibitors of matrix metalloproteinase-1. The American Journal of Pathology. 171: 1762-73. PMID 18055551 DOI: 10.2353/Ajpath.2007.070179 |
0.672 |
|
| 2007 |
Frausto RF, Crocker SJ, Eam B, Whitmire JK, Whitton JL. Myelin oligodendrocyte glycoprotein peptide-induced experimental allergic encephalomyelitis and T cell responses are unaffected by immunoproteasome deficiency. Journal of Neuroimmunology. 192: 124-33. PMID 17964666 DOI: 10.1016/J.Jneuroim.2007.09.024 |
0.685 |
|
| 2007 |
Whitmire JK, Eam B, Benning N, Whitton JL. Direct interferon-gamma signaling dramatically enhances CD4+ and CD8+ T cell memory. Journal of Immunology (Baltimore, Md. : 1950). 179: 1190-7. PMID 17617612 DOI: 10.4049/Jimmunol.179.2.1190 |
0.418 |
|
| 2007 |
Cornell CT, Kiosses WB, Harkins S, Whitton JL. Coxsackievirus B3 proteins directionally complement each other to downregulate surface major histocompatibility complex class I. Journal of Virology. 81: 6785-97. PMID 17442717 DOI: 10.1128/Jvi.00198-07 |
0.376 |
|
| 2007 |
Botten J, Whitton JL, Barrowman P, Sidney J, Whitmire JK, Alexander J, Ting JP, Bui HH, Sette A, Buchmeier MJ. HLA-A2-restricted protection against lethal lymphocytic choriomeningitis. Journal of Virology. 81: 2307-17. PMID 17166907 DOI: 10.1128/Jvi.02063-06 |
0.474 |
|
| 2007 |
Hunziker IP, Cornell CT, Whitton JL. Deletions within the 5'UTR of coxsackievirus B3: consequences for virus translation and replication. Virology. 360: 120-8. PMID 17084431 DOI: 10.1016/J.Virol.2006.09.041 |
0.34 |
|
| 2007 |
Libbey JE, Tsunoda I, Whitton JL, Fujinami RS. Infectious RNA isolated from the spinal cords of mice chronically infected with Theiler's murine encephalomyelitis virus. Journal of Virology. 81: 3009-11. PMID 17005653 DOI: 10.1128/Jvi.01663-06 |
0.327 |
|
| 2006 |
Crocker SJ, Whitmire JK, Frausto RF, Chertboonmuang P, Soloway PD, Whitton JL, Campbell IL. Persistent macrophage/microglial activation and myelin disruption after experimental autoimmune encephalomyelitis in tissue inhibitor of metalloproteinase-1-deficient mice. The American Journal of Pathology. 169: 2104-16. PMID 17148673 DOI: 10.2353/Ajpath.2006.060626 |
0.723 |
|
| 2006 |
Fernandez-Borges N, Brun A, Whitton JL, Parra B, Diaz-San Segundo F, Salguero FJ, Torres JM, Rodriguez F. DNA vaccination can break immunological tolerance to PrP in wild-type mice and attenuates prion disease after intracerebral challenge. Journal of Virology. 80: 9970-6. PMID 17005675 DOI: 10.1128/Jvi.01210-06 |
0.39 |
|
| 2006 |
Botten J, Alexander J, Pasquetto V, Sidney J, Barrowman P, Ting J, Peters B, Southwood S, Stewart B, Rodriguez-Carreno MP, Mothe B, Whitton JL, Sette A, Buchmeier MJ. Identification of protective Lassa virus epitopes that are restricted by HLA-A2. Journal of Virology. 80: 8351-61. PMID 16912286 DOI: 10.1128/Jvi.00896-06 |
0.47 |
|
| 2006 |
Cornell CT, Kiosses WB, Harkins S, Whitton JL. Inhibition of protein trafficking by coxsackievirus b3: multiple viral proteins target a single organelle. Journal of Virology. 80: 6637-47. PMID 16775351 DOI: 10.1128/Jvi.02572-05 |
0.363 |
|
| 2006 |
Whitmire JK, Benning N, Whitton JL. Precursor frequency, nonlinear proliferation, and functional maturation of virus-specific CD4+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 176: 3028-36. PMID 16493061 DOI: 10.4049/Jimmunol.176.5.3028 |
0.425 |
|
| 2006 |
Liu F, Feuer R, Hassett DE, Whitton JL. Peptide vaccination of mice immune to LCMV or vaccinia virus causes serious CD8 T cell-mediated, TNF-dependent immunopathology. The Journal of Clinical Investigation. 116: 465-75. PMID 16424939 DOI: 10.1172/Jci25608 |
0.502 |
|
| 2006 |
Fujinami RS, von Herrath MG, Christen U, Whitton JL. Molecular mimicry, bystander activation, or viral persistence: infections and autoimmune disease. Clinical Microbiology Reviews. 19: 80-94. PMID 16418524 DOI: 10.1128/Cmr.19.1.80-94.2006 |
0.393 |
|
| 2005 |
Whitmire JK, Benning N, Whitton JL. Cutting edge: early IFN-gamma signaling directly enhances primary antiviral CD4+ T cell responses. Journal of Immunology (Baltimore, Md. : 1950). 175: 5624-8. PMID 16237051 DOI: 10.4049/Jimmunol.175.9.5624 |
0.415 |
|
| 2005 |
Whitton JL, Cornell CT, Feuer R. Host and virus determinants of picornavirus pathogenesis and tropism. Nature Reviews. Microbiology. 3: 765-76. PMID 16205710 DOI: 10.1038/Nrmicro1284 |
0.341 |
|
| 2005 |
Nussbaum AK, Rodriguez-Carreno MP, Benning N, Botten J, Whitton JL. Immunoproteasome-deficient mice mount largely normal CD8+ T cell responses to lymphocytic choriomeningitis virus infection and DNA vaccination. Journal of Immunology (Baltimore, Md. : 1950). 175: 1153-60. PMID 16002717 DOI: 10.4049/Jimmunol.175.2.1153 |
0.51 |
|
| 2005 |
Liu F, Whitton JL. Cutting edge: re-evaluating the in vivo cytokine responses of CD8+ T cells during primary and secondary viral infections. Journal of Immunology (Baltimore, Md. : 1950). 174: 5936-40. PMID 15879085 DOI: 10.4049/Jimmunol.174.10.5936 |
0.474 |
|
| 2005 |
Rodriguez-Carreno MP, Nelson MS, Botten J, Smith-Nixon K, Buchmeier MJ, Whitton JL. Evaluating the immunogenicity and protective efficacy of a DNA vaccine encoding Lassa virus nucleoprotein. Virology. 335: 87-98. PMID 15823608 DOI: 10.1016/J.Virol.2005.01.019 |
0.467 |
|
| 2005 |
Whitmire JK, Tan JT, Whitton JL. Interferon-γ acts directly on CD8+ T cells to increase their abundance during virus infection Journal of Experimental Medicine. 201: 1053-1059. PMID 15809350 DOI: 10.1084/Jem.20041463 |
0.472 |
|
| 2005 |
Feuer R, Pagarigan RR, Harkins S, Liu F, Hunziker IP, Whitton JL. Coxsackievirus targets proliferating neuronal progenitor cells in the neonatal CNS Journal of Neuroscience. 25: 2434-2444. PMID 15745971 DOI: 10.1523/Jneurosci.4517-04.2005 |
0.382 |
|
| 2005 |
Harkins S, Cornell CT, Whitton JL. Analysis of translational initiation in coxsackievirus B3 suggests an alternative explanation for the high frequency of R+4 in the eukaryotic consensus motif. Journal of Virology. 79: 987-96. PMID 15613327 DOI: 10.1128/Jvi.79.2.987-996.2005 |
0.303 |
|
| 2004 |
Whitton JL, Feuer R. Myocarditis, microbes and autoimmunity. Autoimmunity. 37: 375-86. PMID 15621561 DOI: 10.1080/08916930410001713089 |
0.384 |
|
| 2004 |
Nussbaum AK, Whitton JL. The contraction phase of virus-specific CD8+ T cells is unaffected by a pan-caspase inhibitor. Journal of Immunology (Baltimore, Md. : 1950). 173: 6611-8. PMID 15557151 DOI: 10.4049/Jimmunol.173.11.6611 |
0.439 |
|
| 2004 |
Whitton JL, Slifka MK, Liu F, Nussbaum AK, Whitmire JK. The regulation and maturation of antiviral immune responses. Advances in Virus Research. 63: 181-238. PMID 15530562 DOI: 10.1016/S0065-3527(04)63003-X |
0.318 |
|
| 2004 |
Hunziker IP, Harkins S, Feuer R, Cornell CT, Whitton JL. Generation and analysis of an RNA vaccine that protects against coxsackievirus B3 challenge. Virology. 330: 196-208. PMID 15527846 DOI: 10.1016/J.Virol.2004.09.035 |
0.353 |
|
| 2004 |
Leifert JA, Rodriguez-Carreno MP, Rodriguez F, Whitton JL. Targeting plasmid-encoded proteins to the antigen presentation pathways. Immunological Reviews. 199: 40-53. PMID 15233725 DOI: 10.1111/J.0105-2896.2004.0135.X |
0.326 |
|
| 2004 |
Liu F, Whitton JL, Slifka MK. The rapidity with which virus-specific CD8+ T cells initiate IFN-gamma synthesis increases markedly over the course of infection and correlates with immunodominance. Journal of Immunology (Baltimore, Md. : 1950). 173: 456-62. PMID 15210805 DOI: 10.4049/Jimmunol.173.1.456 |
0.45 |
|
| 2004 |
Feuer R, Mena I, Pagarigan RR, Hassett DE, Whitton JL. Coxsackievirus replication and the cell cycle: a potential regulatory mechanism for viral persistence/latency. Medical Microbiology and Immunology. 193: 83-90. PMID 12925877 DOI: 10.1007/S00430-003-0192-Z |
0.374 |
|
| 2003 |
von Herrath MG, Fujinami RS, Whitton JL. Microorganisms and autoimmunity: making the barren field fertile? Nature Reviews. Microbiology. 1: 151-7. PMID 15035044 DOI: 10.1038/Nrmicro754 |
0.354 |
|
| 2003 |
Leifert JA, Holler PD, Harkins S, Kranz DM, Whitton JL. The cationic region from HIV tat enhances the cell-surface expression of epitope/MHC class I complexes. Gene Therapy. 10: 2067-73. PMID 14595379 DOI: 10.1038/Sj.Gt.3302115 |
0.309 |
|
| 2003 |
Feuer R, Mena I, Pagarigan RR, Harkins S, Hassett DE, Whitton JL. Coxsackievirus B3 and the neonatal CNS: The roles of stem cells, developing neurons, and apoptosis in infection, viral dissemination, and disease American Journal of Pathology. 163: 1379-1393. PMID 14507646 DOI: 10.1016/S0002-9440(10)63496-7 |
0.41 |
|
| 2002 |
Whitton JL. Immunopathology during coxsackievirus infection. Springer Seminars in Immunopathology. 24: 201-13. PMID 12503065 DOI: 10.1007/S00281-002-0100-4 |
0.311 |
|
| 2002 |
Zhang J, Silvestri N, Whitton JL, Hassett DE. Neonates mount robust and protective adult-like CD8(+)-T-cell responses to DNA vaccines. Journal of Virology. 76: 11911-9. PMID 12414933 DOI: 10.1128/Jvi.76.23.11911-11919.2002 |
0.444 |
|
| 2002 |
Feuer R, Mena I, Pagarigan R, Slifka MK, Whitton JL. Cell cycle status affects coxsackievirus replication, persistence, and reactivation in vitro. Journal of Virology. 76: 4430-40. PMID 11932410 DOI: 10.1128/Jvi.76.9.4430-4440.2002 |
0.444 |
|
| 2002 |
Rodriguez F, Harkins S, Slifka MK, Whitton JL. Immunodominance in virus-induced CD8+ T-cell responses is dramatically modified by DNA immunization and is regulated by gamma interferon Journal of Virology. 76: 4251-4259. PMID 11932390 DOI: 10.1128/Jvi.76.9.4251-4259.2002 |
0.462 |
|
| 2002 |
Harrington LE, Most Rv Rv, Whitton JL, Ahmed R. Recombinant vaccinia virus-induced T-cell immunity: quantitation of the response to the virus vector and the foreign epitope. Journal of Virology. 76: 3329-37. PMID 11884558 DOI: 10.1128/Jvi.76.7.3329-3337.2002 |
0.588 |
|
| 2001 |
von Herrath M, Whitton JL. Animal models using lymphocytic choriomeningitis virus. Current Protocols in Immunology. Unit 19.10. PMID 18432751 DOI: 10.1002/0471142735.Im1910S36 |
0.436 |
|
| 2001 |
Leifert JA, Lindencrona JA, Charo J, Whitton JL. Enhancing T cell activation and antiviral protection by introducing the HIV-1 protein transduction domain into a DNA vaccine. Human Gene Therapy. 12: 1881-92. PMID 11589830 DOI: 10.1089/104303401753153938 |
0.489 |
|
| 2001 |
Rodriguez F, Harkins S, Redwine JM, De Pereda JM, Whitton JL. CD4+ T cells induced by a DNA vaccine: Immunological consequences of epitope-specific lysosomal targeting Journal of Virology. 75: 10421-10430. PMID 11581410 DOI: 10.1128/Jvi.75.21.10421-10430.2001 |
0.462 |
|
| 2001 |
Theil DJ, Tsunoda I, Rodriguez F, Whitton JL, Fujinami RS. Viruses can silently prime for and trigger central nervous system autoimmune disease Journal of Neurovirology. 7: 220-227. PMID 11517396 DOI: 10.1080/13550280152403263 |
0.413 |
|
| 2001 |
Slifka MK, Whitton JL. Functional avidity maturation of CD8(+) T cells without selection of higher affinity TCR. Nature Immunology. 2: 711-7. PMID 11477407 DOI: 10.1038/90650 |
0.422 |
|
| 2001 |
Rodriguez F, Slifka MK, Harkins S, Whitton JL. Two overlapping subdominant epitopes identified by DNA immunization induce protective CD8+ T-cell populations with differing cytolytic activities Journal of Virology. 75: 7399-7409. PMID 11462012 DOI: 10.1128/JVI.75.16.7399-7409.2001 |
0.395 |
|
| 2001 |
Whitton JL, Fujinami RS. DNA immunization and central nervous system viral infection. Advances in Virus Research. 56: 243-73. PMID 11450302 DOI: 10.1016/S0065-3527(01)56030-3 |
0.435 |
|
| 2001 |
Slifka MK, Pagarigan R, Mena I, Feuer R, Whitton JL. Using recombinant coxsackievirus B3 to evaluate the induction and protective efficacy of CD8+ T cells during picornavirus infection. Journal of Virology. 75: 2377-87. PMID 11160741 DOI: 10.1128/Jvi.75.5.2377-2387.2001 |
0.447 |
|
| 2000 |
Hassett DE, Slifka MK, Zhang J, Whitton JL. Direct ex vivo kinetic and phenotypic analyses of CD8(+) T-cell responses induced by DNA immunization. Journal of Virology. 74: 8286-91. PMID 10954526 DOI: 10.1128/Jvi.74.18.8286-8291.2000 |
0.484 |
|
| 2000 |
Mena I, Fischer C, Gebhard JR, Perry CM, Harkins S, Whitton JL. Coxsackievirus infection of the pancreas: Evaluation of receptor expression, pathogenesis, and immunopathology Virology. 271: 276-288. PMID 10860882 DOI: 10.1006/Viro.2000.0332 |
0.472 |
|
| 2000 |
Slifka MK, Whitton JL. Antigen-specific regulation of T cell-mediated cytokine production. Immunity. 12: 451-7. PMID 10843378 DOI: 10.1016/S1074-7613(00)80197-1 |
0.315 |
|
| 2000 |
Slifka MK, Whitton JL. Clinical implications of dysregulated cytokine production. Journal of Molecular Medicine (Berlin, Germany). 78: 74-80. PMID 10794542 DOI: 10.1007/S001090000086 |
0.412 |
|
| 2000 |
Xiang R, Lode HN, Chao TH, Ruehlmann JM, Dolman CS, Rodriguez F, Whitton JL, Overwijk WW, Restifo NP, Reisfeld RA. An autologous oral DNA vaccine protects against murine melanoma. Proceedings of the National Academy of Sciences of the United States of America. 97: 5492-7. PMID 10779556 DOI: 10.1073/Pnas.090097697 |
0.402 |
|
| 2000 |
An LL, Rodriguez F, Harkins S, Zhang J, Whitton JL. Quantitative and qualitative analyses of the immune responses induced by a multivalent minigene DNA vaccine Vaccine. 18: 2132-2141. PMID 10715528 DOI: 10.1016/S0264-410X(99)00546-0 |
0.453 |
|
| 2000 |
Sevilla N, Homann D, von Herrath M, Rodriguez F, Harkins S, Whitton JL, Oldstone MB. Virus-induced diabetes in a transgenic model: role of cross-reacting viruses and quantitation of effector T cells needed to cause disease. Journal of Virology. 74: 3284-92. PMID 10708445 DOI: 10.1128/Jvi.74.7.3284-3292.2000 |
0.573 |
|
| 2000 |
Rodriguez F, Whitton JL. Enhancing DNA immunization. Virology. 268: 233-8. PMID 10704331 DOI: 10.1006/Viro.2000.0209 |
0.327 |
|
| 2000 |
Hassett DE, Zhang J, Slifka M, Whitton JL. Immune responses following neonatal DNA vaccination are long-lived, abundant, and qualitatively similar to those induced by conventional immunization. Journal of Virology. 74: 2620-7. PMID 10684276 DOI: 10.1128/Jvi.74.6.2620-2627.2000 |
0.445 |
|
| 2000 |
Slifka MK, Pagarigan RR, Whitton JL. NK markers are expressed on a high percentage of virus-specific CD8+ and CD4+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 164: 2009-15. PMID 10657652 DOI: 10.4049/Jimmunol.164.4.2009 |
0.442 |
|
| 2000 |
Slifka MK, Whitton JL. Activated and memory CD8+ T cells can be distinguished by their cytokine profiles and phenotypic markers. Journal of Immunology. 164: 208-216. PMID 10605013 DOI: 10.4049/Jimmunol.164.1.208 |
0.408 |
|
| 1999 |
Hassett DE, Zhang J, Whitton JL. Plasmid DNA Vaccines Are Effective in the Absence of IFNγ Virology. 263: 175-183. PMID 10544092 DOI: 10.1006/Viro.1999.9957 |
0.421 |
|
| 1999 |
Mena I, Perry CM, Harkins S, Rodriguez F, Gebhard J, Whitton JL. The role of B lymphocytes in coxsackievirus B3 infection American Journal of Pathology. 155: 1205-1215. PMID 10514403 DOI: 10.1016/S0002-9440(10)65223-6 |
0.451 |
|
| 1999 |
Slifka MK, Rodriguez F, Whitton JL. Rapid on/off cycling of cytokine production by virus-specific CD8 + T cells Nature. 401: 76-79. PMID 10485708 DOI: 10.1038/43454 |
0.497 |
|
| 1999 |
Whitton JL, Fujinami RS. Viruses as triggers of autoimmunity: facts and fantasies. Current Opinion in Microbiology. 2: 392-7. PMID 10458987 DOI: 10.1016/S1369-5274(99)80069-1 |
0.33 |
|
| 1999 |
Hassett DE, Zhang J, Whitton JL. Induction of Antiviral Antibodies by DNA Immunization Requires neither Perforin-Mediated nor CD8+-T-Cell-Mediated Lysis of Antigen-Expressing Cells Journal of Virology. 73: 7870-7873. PMID 10438882 DOI: 10.1128/Jvi.73.9.7870-7873.1999 |
0.429 |
|
| 1999 |
Ochsenbein AF, Karrer U, Klenerman P, Althage A, Ciurea A, Shen H, Miller JF, Whitton JL, Hengartner H, Zinkernagel RM. A comparison of T cell memory against the same antigen induced by virus versus intracellular bacteria. Proceedings of the National Academy of Sciences of the United States of America. 96: 9293-8. PMID 10430936 DOI: 10.1073/Pnas.96.16.9293 |
0.346 |
|
| 1999 |
Tsunoda I, Tolley ND, Theil DJ, Whitton JL, Kobayashi H, Fujinami RS. Exacerbation of viral and autoimmune animal models for multiple sclerosis by bacterial DNA Brain Pathology. 9: 481-493. PMID 10416988 DOI: 10.1111/J.1750-3639.1999.Tb00537.X |
0.403 |
|
| 1999 |
Coon B, An L, Whitton JL, Herrath MGv. DNA immunization to prevent autoimmune diabetes Journal of Clinical Investigation. 104: 189-194. PMID 10411548 DOI: 10.1172/Jci7209 |
0.399 |
|
| 1999 |
Wang LY, Theil DJ, Whitton JL, Fujinami RS. Infection with a recombinant vaccinia virus encoding myelin proteolipid protein causes suppression of chronic relapsing-remitting experimental allergic encephalomyelitis. Journal of Neuroimmunology. 96: 148-57. PMID 10337913 DOI: 10.1016/S0165-5728(99)00020-X |
0.413 |
|
| 1999 |
Whitton JL, Rodriguez F, Zhang J, Hassett DE. DNA immunization: mechanistic studies Vaccine. 17: 1612-1619. PMID 10194813 DOI: 10.1016/S0264-410X(98)00418-6 |
0.413 |
|
| 1999 |
Oldstone MB, von Herrath M, Lewicki H, Hudrisier D, Whitton JL, Gairin JE. Use of a high-affinity peptide that aborts MHC-restricted cytotoxic T lymphocyte activity against multiple viruses in vitro and virus-induced immunopathologic disease in vivo. Virology. 256: 246-57. PMID 10191190 DOI: 10.1006/Viro.1998.9593 |
0.571 |
|
| 1999 |
Lewis AJ, Whitton JL, Hatalski CG, Weissenböck H, Lipkin WI. Effect of immune priming on Borna disease. Journal of Virology. 73: 2541-6. PMID 9971840 DOI: 10.1128/Jvi.73.3.2541-2546.1999 |
0.401 |
|
| 1998 |
Henke A, Wagner E, Whitton JL, Zell R, Stelzner A. Protection of Mice against Lethal Coxsackievirus B3 Infection by Using DNA Immunization Journal of Virology. 72: 8327-8331. PMID 9733878 DOI: 10.1128/Jvi.72.10.8327-8331.1998 |
0.396 |
|
| 1998 |
Tsunoda I, Kuang LQ, Tolley ND, Whitton JL, Fujinami RS. Enhancement of experimental allergic encephalomyelitis (EAE) by DNA immunization with myelin proteolipid protein (PLP) plasmid DNA Journal of Neuropathology and Experimental Neurology. 57: 758-767. PMID 9720491 DOI: 10.1097/00005072-199808000-00005 |
0.363 |
|
| 1998 |
Gebhard JR, Perry CM, Harkins S, Lane T, Mena I, Asensio VC, Campbell IL, Whitton JL. Coxsackievirus B3-induced myocarditis: perforin exacerbates disease, but plays no detectable role in virus clearance. The American Journal of Pathology. 153: 417-28. PMID 9708802 DOI: 10.1016/S0002-9440(10)65585-X |
0.596 |
|
| 1998 |
Rodriguez F, An LL, Harkins S, Zhang J, Yokoyama M, Widera G, Fuller JT, Kincaid C, Campbell IL, Whitton JL. DNA immunization with minigenes: low frequency of memory cytotoxic T lymphocytes and inefficient antiviral protection are rectified by ubiquitination. Journal of Virology. 72: 5174-81. PMID 9573289 DOI: 10.1128/Jvi.72.6.5174-5181.1998 |
0.628 |
|
| 1998 |
Whitton JL. An overview of antigen presentation and its central role in the immune response. Current Topics in Microbiology and Immunology. 232: 1-13. PMID 9557391 DOI: 10.1007/978-3-642-72045-1_1 |
0.323 |
|
| 1998 |
Most RGvd, Murali-Krishna K, Whitton JL, Oseroff C, Alexander J, Southwood S, Sidney J, Chesnut RW, Sette A, Ahmed R. Identification of Db- and Kb-Restricted Subdominant Cytotoxic T-Cell Responses in Lymphocytic Choriomeningitis Virus-Infected Mice Virology. 240: 158-167. PMID 9448700 DOI: 10.1006/Viro.1997.8934 |
0.545 |
|
| 1997 |
Rodriguez F, Zhang J, Whitton JL. DNA immunization: ubiquitination of a viral protein enhances cytotoxic T-lymphocyte induction and antiviral protection but abrogates antibody induction. Journal of Virology. 71: 8497-503. PMID 9343207 DOI: 10.1128/JVI.71.11.8497-8503.1997 |
0.323 |
|
| 1997 |
Yokoyama M, Hassett DE, Zhang J, Whitton JL. DNA immunization can stimulate florid local inflammation, and the antiviral immunity induced varies depending on injection site. Vaccine. 15: 553-60. PMID 9160524 DOI: 10.1016/S0264-410X(97)00213-2 |
0.368 |
|
| 1997 |
Gebhard JR, Perry CM, Mahadeviah S, Whitton JL. Use of a Nonviral Vector to Express a Chimeric tRNA-Ribozyme Against Lymphocytic Choriomeningitis Virus: Cytoplasmic Accumulation of a Catalytically Competent Transcript but Minimal Antiviral Effect Antisense & Nucleic Acid Drug Development. 7: 3-11. PMID 9055033 DOI: 10.1089/Oli.1.1997.7.3 |
0.301 |
|
| 1997 |
An LL, Whitton JL. A multivalent minigene vaccine, containing B-cell, cytotoxic T-lymphocyte, and Th epitopes from several microbes, induces appropriate responses in vivo and confers protection against more than one pathogen. Journal of Virology. 71: 2292-302. PMID 9032365 DOI: 10.1128/JVI.71.3.2292-2302.1997 |
0.351 |
|
| 1996 |
Whitton JL, Yokoyama M. Proteins expressed by DNA vaccines induce both local and systemic immune responses. Annals of the New York Academy of Sciences. 797: 196-206. PMID 8993363 DOI: 10.1111/J.1749-6632.1996.Tb52961.X |
0.323 |
|
| 1996 |
Hildeman D, Salvato M, Whitton JL, Muller D. Vaccination protects β2 microglobulin deficient mice from immune mediated mortality but not from persisting viral infection Vaccine. 14: 1223-1229. PMID 8961509 DOI: 10.1016/S0264-410X(96)00028-X |
0.379 |
|
| 1996 |
Yokoyama M, Zhang J, Whitton JL. DNA immunization: Effects of vehicle and route of administration on the induction of protective antiviral immunity Fems Immunology and Medical Microbiology. 14: 221-230. PMID 8856321 DOI: 10.1111/J.1574-695X.1996.Tb00290.X |
0.347 |
|
| 1996 |
Barnett LA, Whitton JL, Wang LY, Fujinami RS. Virus encoding an encephalitogenic peptide protects mice from experimental allergic encephalomyelitis. Journal of Neuroimmunology. 64: 163-73. PMID 8632058 DOI: 10.1016/0165-5728(95)00165-4 |
0.518 |
|
| 1996 |
von Herrath MG, Yokoyama M, Dockter J, Oldstone MB, Whitton JL. CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge. Journal of Virology. 70: 1072-9. PMID 8551565 |
0.522 |
|
| 1996 |
Yokoyama M, Zhang J, Whitton JL. Research articleDNA immunization: Effects of vehicle and route of administration on the induction of protective antiviral immunity Fems Immunology and Medical Microbiology. 14. DOI: 10.1016/0928-8244(96)00033-8 |
0.349 |
|
| 1995 |
Xing Z, Mahadeviah S, Whitton JL. Antiviral Activity of RNA Molecules Containing Self-Releasing Ribozymes Targeted to Lymphocytic Choriomeningitis Virus Antisense Research and Development. 5: 203-212. PMID 8785476 DOI: 10.1089/Ard.1995.5.203 |
0.341 |
|
| 1995 |
Yokoyama M, Zhang J, Whitton JL. DNA immunization confers protection against lethal lymphocytic choriomeningitis virus infection. Journal of Virology. 69: 2684-8. PMID 7884923 DOI: 10.1128/JVI.69.4.2684-2688.1995 |
0.31 |
|
| 1995 |
Lewicki HA, Von Herrath MG, Evans CF, Whitton JL, Oldstone MB. CTL escape viral variants. II. Biologic activity in vivo. Virology. 211: 443-50. PMID 7645248 DOI: 10.1006/viro.1995.1426 |
0.5 |
|
| 1995 |
Henke A, Huber S, Stelzner A, Whitton JL. The role of CD8+ T lymphocytes in coxsackievirus B3-induced myocarditis. Journal of Virology. 69: 6720-8. PMID 7474082 DOI: 10.1128/JVI.69.11.6720-6728.1995 |
0.358 |
|
| 1994 |
Doherty PC, Hou S, Evans CF, Whitton JL, Oldstone MB, Blackman MA. Limiting the available T cell receptor repertoire modifies acute lymphocytic choriomeningitis virus-induced immunopathology. Journal of Neuroimmunology. 51: 147-52. PMID 8182114 DOI: 10.1016/0165-5728(94)90076-0 |
0.515 |
|
| 1994 |
Whitton JL. Induction of protective immunity using minigenes. Annals of the New York Academy of Sciences. 730: 107-117. PMID 7521600 DOI: 10.1111/J.1749-6632.1994.Tb44243.X |
0.308 |
|
| 1993 |
Oldstone MB, Tishon A, Eddleston M, de la Torre JC, McKee T, Whitton JL. Vaccination to prevent persistent viral infection. Journal of Virology. 67: 4372-8. PMID 8510226 DOI: 10.1128/Jvi.67.7.4372-4378.1993 |
0.526 |
|
| 1993 |
Barnett LA, Whitton JL, Wada Y, Fujinami RS. Enhancement of autoimmune disease using recombinant vaccinia virus encoding myelin proteolipid protein. Journal of Neuroimmunology. 44: 15-25. PMID 7684398 DOI: 10.1016/0165-5728(93)90263-X |
0.41 |
|
| 1993 |
Whitton JL, Sheng N, Oldstone MB, McKee TA. A "string-of-beads" vaccine, comprising linked minigenes, confers protection from lethal-dose virus challenge. Journal of Virology. 67: 348-52. PMID 7677954 |
0.488 |
|
| 1992 |
Oldstone MB, Tishon A, Geckeler R, Lewicki H, Whitton JL. A common antiviral cytotoxic T-lymphocyte epitope for diverse major histocompatibility complex haplotypes: implications for vaccination. Proceedings of the National Academy of Sciences of the United States of America. 89: 2752-5. PMID 1372990 |
0.509 |
|
| 1992 |
Muller D, Koller BH, Whitton JL, Lapan KE, Brigman KK, Frelinger JA. LCMV-specific, class II-restricted cytotoxic T cells in β2-microglobulin-deficient mice Science. 255: 1576-1578. PMID 1347959 DOI: 10.1126/Science.1347959 |
0.326 |
|
| 1992 |
Lewicki H, McKee TA, Tishon A, Salvato M, Whitton JL, Oldstone MB. Novel LCMV-specific H-2k restricted CTL clones recognize internal viral gene products and cause CNS disease. Journal of Neuroimmunology. 41: 15-20. PMID 1281166 DOI: 10.1016/0165-5728(92)90190-V |
0.579 |
|
| 1990 |
Klavinskis LS, Whitton JL, Joly E, Oldstone MB. Vaccination and protection from a lethal viral infection: identification, incorporation, and use of a cytotoxic T lymphocyte glycoprotein epitope. Virology. 178: 393-400. PMID 1699348 DOI: 10.1016/0042-6822(90)90336-P |
0.594 |
|
| 1989 |
Klavinskis LS, Whitton JL, Oldstone MB. Molecularly engineered vaccine which expresses an immunodominant T-cell epitope induces cytotoxic T lymphocytes that confer protection from lethal virus infection. Journal of Virology. 63: 4311-6. PMID 2476571 DOI: 10.1128/JVI.63.10.4311-4316.1989 |
0.546 |
|
| 1989 |
Whitton JL, Tishon A, Lewicki H, Gebhard J, Cook T, Salvato M, Joly E, Oldstone MBA. Molecular analysis of a five-amino-acid cytotoxic T-lymphocyte (CTL) epitope: An immunodominant region which induces nonreciprocal CTL cross-reactivity Journal of Virology. 63: 4303-4310. PMID 2476570 DOI: 10.1128/JVI.63.10.4303-4310.1989 |
0.334 |
|
| 1989 |
Whitton JL, Oldstone MB. Class I MHC can present an endogenous peptide to cytotoxic T lymphocytes. The Journal of Experimental Medicine. 170: 1033-8. PMID 2475568 DOI: 10.1084/JEM.170.3.1033 |
0.51 |
|
| 1988 |
Whitton JL, Southern PJ, Oldstone MBA. Analyses of the cytotoxic T lymphocyte responses to glycoprotein and nucleoprotein components of lymphocytic choriomeningitis virus Virology. 162: 321-327. PMID 3257596 DOI: 10.1016/0042-6822(88)90471-0 |
0.438 |
|
| 1988 |
Oldstone MB, Whitton JL, Lewicki H, Tishon A. Fine dissection of a nine amino acid glycoprotein epitope, a major determinant recognized by lymphocytic choriomeningitis virus-specific class I-restricted H-2Db cytotoxic T lymphocytes. The Journal of Experimental Medicine. 168: 559-70. PMID 2457647 DOI: 10.1084/JEM.168.2.559 |
0.437 |
|
| 1988 |
Whitton JL, Gebhard JR, Lewicki H, Tishon A, Oldstone MB. Molecular definition of a major cytotoxic T-lymphocyte epitope in the glycoprotein of lymphocytic choriomeningitis virus. Journal of Virology. 62: 687-95. PMID 2448497 DOI: 10.1128/JVI.62.3.687-695.1988 |
0.482 |
|
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