| Year |
Citation |
Score |
| 2024 |
Palko SI, Benoit MR, Yao AY, Mohan R, Yan R. ER-stress response in retinal Müller glia occurs significantly earlier than amyloid pathology in the Alzheimer's mouse brain and retina. Glia. PMID 38497356 DOI: 10.1002/glia.24514 |
0.681 |
|
| 2024 |
Huang H, Sharoar MG, Pathoulas J, Fan L, He W, Xiang R, Yan R. Accumulation of neutral lipids in dystrophic neurites surrounding amyloid plaques in Alzheimer's disease. Biochimica Et Biophysica Acta. Molecular Basis of Disease. 1870: 167086. PMID 38378084 DOI: 10.1016/j.bbadis.2024.167086 |
0.335 |
|
| 2023 |
Hudobenko J, Gayen M, Benoit MR, Singh N, Yan R. Exploration of C-terminal CX3CL1 for reducing age-dependent neurodegeneration. Neural Regeneration Research. 18: 2667-2668. PMID 37449614 DOI: 10.4103/1673-5374.373702 |
0.611 |
|
| 2023 |
Zhou J, Singh N, Galske J, Hudobenko J, Hu X, Yan R. BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides. Molecular Neurodegeneration. 18: 31. PMID 37143090 DOI: 10.1186/s13024-023-00611-w |
0.408 |
|
| 2022 |
Benoit M, Darboe M, Das B, Ge Y, Zhou J, Yao A, He W, Yan R, Hu X. Postnatal neuronal Bace1 deletion impairs neuroblast and oligodendrocyte maturation. Human Molecular Genetics. PMID 36370042 DOI: 10.1093/hmg/ddac282 |
0.664 |
|
| 2022 |
Gayen M, Benoit MR, Fan Q, Hudobenko J, Yan R. The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/ insulin like growth factor receptor signaling. The Journal of Biological Chemistry. 102532. PMID 36162508 DOI: 10.1016/j.jbc.2022.102532 |
0.648 |
|
| 2022 |
Singh N, Das B, Zhou J, Hu X, Yan R. Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance. Science Advances. 8: eabo3610. PMID 35857844 DOI: 10.1126/sciadv.abo3610 |
0.398 |
|
| 2022 |
Singh N, Benoit MR, Zhou J, Das B, Davila-Velderrain J, Kellis M, Tsai LH, Hu X, Yan R. BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1. Science Advances. 8: eabo1286. PMID 35714196 DOI: 10.1126/sciadv.abo1286 |
0.698 |
|
| 2021 |
Islam MI, Nagakannan P, Shcholok T, Contu F, Mai S, Albensi BC, Del Bigio MR, Wang JF, Sharoar MG, Yan R, Park IS, Eftekharpour E. Regulatory role of cathepsin L in induction of nuclear laminopathy in Alzheimer's disease. Aging Cell. e13531. PMID 34905652 DOI: 10.1111/acel.13531 |
0.311 |
|
| 2021 |
McDade E, Voytyuk I, Aisen P, Bateman RJ, Carrillo MC, De Strooper B, Haass C, Reiman EM, Sperling R, Tariot PN, Yan R, Masters CL, Vassar R, Lichtenthaler SF. The case for low-level BACE1 inhibition for the prevention of Alzheimer disease. Nature Reviews. Neurology. PMID 34548654 DOI: 10.1038/s41582-021-00545-1 |
0.308 |
|
| 2021 |
Sharoar MG, Zhou J, Benoit M, He W, Yan R. Dynactin 6 deficiency enhances aging-associated dystrophic neurite formation in mouse brains. Neurobiology of Aging. 107: 21-29. PMID 34371284 DOI: 10.1016/j.neurobiolaging.2021.07.006 |
0.689 |
|
| 2021 |
Sharoar MG, Palko S, Ge Y, Saido TC, Yan R. Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer's disease brains. Molecular Neurodegeneration. 16: 45. PMID 34215298 DOI: 10.1186/s13024-021-00464-1 |
0.41 |
|
| 2020 |
Yao AY, Yan R. Activity of Alzheimer's γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity. Molecular Neurodegeneration. 15: 69. PMID 33183335 DOI: 10.1186/s13024-020-00417-0 |
0.332 |
|
| 2020 |
Hampel H, Vassar R, De Strooper B, Hardy J, Willem M, Singh N, Zhou J, Yan R, Vanmechelen E, De Vos A, Nisticò R, Corbo M, Imbimbo BP, Streffer J, Voytyuk I, et al. The β-Secretase BACE1 in Alzheimer's Disease. Biological Psychiatry. PMID 32223911 DOI: 10.1016/J.Biopsych.2020.02.001 |
0.497 |
|
| 2019 |
Fan Q, He W, Gayen M, Robert Benoit M, Luo X, Hu X, Yan R. Activated CX3CL1/Smad2 signals prevent neuronal loss and Alzheimer's tau pathology-mediated cognitive dysfunction. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31822518 DOI: 10.1523/Jneurosci.1333-19.2019 |
0.477 |
|
| 2019 |
Benoit MR, Gayen M, Yan R. CX3CL1 intracellular domain and adult neurogenesis. Aging. PMID 31785144 DOI: 10.18632/aging.102504 |
0.593 |
|
| 2019 |
Sharoar MG, Hu X, Ma XM, Zhu X, Yan R. Dystrophic neurites labelled by pre-autophagosomal proteins in Alzheimer's brains. Molecular Psychiatry. 24: 1247. PMID 31439921 DOI: 10.1038/S41380-019-0476-3 |
0.37 |
|
| 2019 |
Fan Q, Gayen M, Singh N, Gao F, He W, Hu X, Tsai LH, Yan R. The intracellular domain of CX3CL1 regulates adult neurogenesis and Alzheimer's amyloid pathology. The Journal of Experimental Medicine. PMID 31209068 DOI: 10.1084/Jem.20182238 |
0.467 |
|
| 2019 |
Sharoar MG, Hu X, Ma XM, Zhu X, Yan R. Sequential formation of different layers of dystrophic neurites in Alzheimer's brains. Molecular Psychiatry. PMID 30899091 DOI: 10.1038/S41380-019-0396-2 |
0.461 |
|
| 2019 |
Das B, Yan R. A Close Look at BACE1 Inhibitors for Alzheimer's Disease Treatment. Cns Drugs. PMID 30830576 DOI: 10.1007/S40263-019-00613-7 |
0.469 |
|
| 2018 |
Wang C, Zhao F, Shen K, Wang W, Siedlak SL, Lee HG, Phelix CF, Perry G, Shen L, Tang B, Yan R, Zhu X. The sterol regulatory element-binding protein 2 is likely dysregulated by tau alterations in Alzheimer disease. Brain Pathology (Zurich, Switzerland). PMID 30515907 DOI: 10.1111/Bpa.12691 |
0.479 |
|
| 2018 |
Hu X, Das B, Hou H, He W, Yan R. BACE1 deletion in the adult mouse reverses preformed amyloid deposition and improves cognitive functions. The Journal of Experimental Medicine. PMID 29444819 DOI: 10.1084/Jem.20171831 |
0.484 |
|
| 2018 |
Zou Y, He W, Wang K, Han H, Xiao T, Chen X, Zhou B, Tan J, Xia K, Tang B, Chen C, Shen L, Yan R, Zhang Z. Identification of rare RTN3 variants in Alzheimer's disease in Han Chinese. Human Genetics. PMID 29356939 DOI: 10.1007/S00439-018-1868-1 |
0.396 |
|
| 2018 |
Sharoar MG, Hu X, Yan R. P1-206: The Constitution Of Dystrophic Neurites In Aging And In Alzheimer'S Disease Mouse Model Brain And Their 3D Structures Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.211 |
0.362 |
|
| 2017 |
Das B, Yan R. Role of BACE1 in Alzheimer's synaptic function. Translational Neurodegeneration. 6: 23. PMID 28855981 DOI: 10.1186/S40035-017-0093-5 |
0.472 |
|
| 2017 |
Shi Q, Ge Y, He W, Hu X, Yan R. RTN1 and RTN3 protein are differentially associated with senile plaques in Alzheimer's brains. Scientific Reports. 7: 6145. PMID 28733667 DOI: 10.1038/S41598-017-05504-9 |
0.47 |
|
| 2017 |
Hou H, Fan Q, He W, Suh H, Hu X, Yan R. BACE1 Deficiency Causes Abnormal Neuronal Clustering in the Dentate Gyrus. Stem Cell Reports. PMID 28669600 DOI: 10.1016/J.Stemcr.2017.05.030 |
0.391 |
|
| 2017 |
Hu X, Hou H, Bastian C, He W, Qiu S, Ge Y, Yin X, Kidd GJ, Brunet S, Trapp BD, Baltan S, Yan R. BACE1 regulates the proliferation and cellular functions of Schwann cells. Glia. PMID 28191691 DOI: 10.1002/Glia.23122 |
0.415 |
|
| 2016 |
Sharoar MG, Yan R. Effects of altered RTN3 expression on BACE1 activity and Alzheimer's neuritic plaques. Reviews in the Neurosciences. PMID 27883331 DOI: 10.1515/Revneuro-2016-0054 |
0.512 |
|
| 2016 |
Yan R. Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugs. Translational Neurodegeneration. 5: 13. PMID 27418961 DOI: 10.1186/S40035-016-0061-5 |
0.48 |
|
| 2016 |
Yan R, Fan Q, Zhou J, Vassar R. Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease. Neuroscience and Biobehavioral Reviews. PMID 27044452 DOI: 10.1016/J.Neubiorev.2016.03.025 |
0.444 |
|
| 2015 |
Sharoar MG, Shi Q, Ge Y, He W, Hu X, Perry G, Zhu X, Yan R. Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer's disease. Molecular Psychiatry. PMID 26619807 DOI: 10.1038/Mp.2015.181 |
0.447 |
|
| 2015 |
Hu X, Fan Q, Hou H, Yan R. Neurological dysfunctions associated with altered BACE1-dependent Neuregulin-1 signaling. Journal of Neurochemistry. PMID 26465092 DOI: 10.1111/Jnc.13395 |
0.4 |
|
| 2015 |
Hu X, Hu J, Dai L, Trapp B, Yan R. Axonal and Schwann cell BACE1 is equally required for remyelination of peripheral nerves. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 3806-14. PMID 25740511 DOI: 10.1523/Jneurosci.5207-14.2015 |
0.351 |
|
| 2014 |
Shi Q, Ge Y, Sharoar MG, He W, Xiang R, Zhang Z, Hu X, Yan R. Impact of RTN3 deficiency on expression of BACE1 and amyloid deposition. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 13954-62. PMID 25319692 DOI: 10.1523/Jneurosci.1588-14.2014 |
0.488 |
|
| 2014 |
He W, Hu J, Xia Y, Yan R. β-site amyloid precursor protein cleaving enzyme 1(BACE1) regulates Notch signaling by controlling the cleavage of Jagged 1 (Jag1) and Jagged 2 (Jag2) proteins. The Journal of Biological Chemistry. 289: 20630-7. PMID 24907271 DOI: 10.1074/Jbc.M114.579862 |
0.425 |
|
| 2014 |
Yan R, Vassar R. Targeting the β secretase BACE1 for Alzheimer's disease therapy. The Lancet. Neurology. 13: 319-29. PMID 24556009 DOI: 10.1016/S1474-4422(13)70276-X |
0.389 |
|
| 2014 |
Luo X, He W, Hu X, Yan R. Reversible overexpression of bace1-cleaved neuregulin-1 N-terminal fragment induces schizophrenia-like phenotypes in mice. Biological Psychiatry. 76: 120-7. PMID 24210810 DOI: 10.1016/J.Biopsych.2013.09.026 |
0.358 |
|
| 2013 |
Deng M, He W, Tan Y, Han H, Hu X, Xia K, Zhang Z, Yan R. Increased expression of reticulon 3 in neurons leads to reduced axonal transport of β site amyloid precursor protein-cleaving enzyme 1. The Journal of Biological Chemistry. 288: 30236-45. PMID 24005676 DOI: 10.1074/jbc.M113.480079 |
0.33 |
|
| 2013 |
Hu X, He W, Luo X, Tsubota KE, Yan R. BACE1 regulates hippocampal astrogenesis via the Jagged1-Notch pathway. Cell Reports. 4: 40-9. PMID 23831026 DOI: 10.1016/J.Celrep.2013.06.005 |
0.449 |
|
| 2013 |
Shi Q, Prior M, Zhou X, Tang X, He W, Hu X, Yan R. Preventing formation of reticulon 3 immunoreactive dystrophic neurites improves cognitive function in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 3059-66. PMID 23407961 DOI: 10.1523/Jneurosci.2445-12.2013 |
0.447 |
|
| 2013 |
Hu X, Schlanger R, He W, Macklin WB, Yan R. Reversing hypomyelination in BACE1-null mice with Akt-DD overexpression. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 1868-73. PMID 23335052 DOI: 10.1096/Fj.12-224212 |
0.429 |
|
| 2011 |
Wen L, Tang FL, Hong Y, Luo SW, Wang CL, He W, Shen C, Jung JU, Xiong F, Lee DH, Zhang QG, Brann D, Kim TW, Yan R, Mei L, et al. VPS35 haploinsufficiency increases Alzheimer's disease neuropathology. The Journal of Cell Biology. 195: 765-79. PMID 22105352 DOI: 10.1083/Jcb.201105109 |
0.496 |
|
| 2011 |
Zhou X, Hu X, He W, Tang X, Shi Q, Zhang Z, Yan R. Interaction between amyloid precursor protein and Nogo receptors regulates amyloid deposition. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 3146-56. PMID 21670066 DOI: 10.1096/Fj.11-184325 |
0.497 |
|
| 2011 |
Luo X, Prior M, He W, Hu X, Tang X, Shen W, Yadav S, Kiryu-Seo S, Miller R, Trapp BD, Yan R. Cleavage of neuregulin-1 by BACE1 or ADAM10 protein produces differential effects on myelination. The Journal of Biological Chemistry. 286: 23967-74. PMID 21576249 DOI: 10.1074/Jbc.M111.251538 |
0.367 |
|
| 2011 |
Cui S, Xiong F, Hong Y, Jung JU, Li XS, Liu JZ, Yan R, Mei L, Feng X, Xiong WC. APPswe/Aβ regulation of osteoclast activation and RAGE expression in an age-dependent manner. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 26: 1084-98. PMID 21542009 DOI: 10.1002/Jbmr.299 |
0.459 |
|
| 2010 |
Luo X, Yan R. Inhibition of BACE1 for therapeutic use in Alzheimer's disease. International Journal of Clinical and Experimental Pathology. 3: 618-28. PMID 20661410 |
0.339 |
|
| 2010 |
Hu X, Zhou X, He W, Yang J, Xiong W, Wong P, Wilson CG, Yan R. BACE1 deficiency causes altered neuronal activity and neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 8819-29. PMID 20592204 DOI: 10.1523/Jneurosci.1334-10.2010 |
0.424 |
|
| 2010 |
Heath JE, Siedlak SL, Zhu X, Lee HG, Thakur A, Yan R, Perry G, Smith MA, Castellani RJ. Widespread distribution of reticulon-3 in various neurodegenerative diseases. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 30: 574-9. PMID 20374499 DOI: 10.1111/J.1440-1789.2010.01107.X |
0.467 |
|
| 2010 |
Prior M, Shi Q, Hu X, He W, Levey A, Yan R. RTN/Nogo in forming Alzheimer's neuritic plaques. Neuroscience and Biobehavioral Reviews. 34: 1201-6. PMID 20144652 DOI: 10.1016/J.Neubiorev.2010.01.017 |
0.494 |
|
| 2009 |
Vassar R, Kovacs DM, Yan R, Wong PC. The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12787-94. PMID 19828790 DOI: 10.1523/Jneurosci.3657-09.2009 |
0.441 |
|
| 2009 |
Shi Q, Prior M, He W, Tang X, Hu X, Yan R. Reduced amyloid deposition in mice overexpressing RTN3 is adversely affected by preformed dystrophic neurites. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 9163-73. PMID 19625507 DOI: 10.1523/Jneurosci.5741-08.2009 |
0.46 |
|
| 2009 |
Shi Q, Hu X, Prior M, Yan R. The occurrence of aging-dependent reticulon 3 immunoreactive dystrophic neurites decreases cognitive function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 5108-15. PMID 19386906 DOI: 10.1523/Jneurosci.5887-08.2009 |
0.46 |
|
| 2008 |
Hu X, He W, Diaconu C, Tang X, Kidd GJ, Macklin WB, Trapp BD, Yan R. Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 2970-80. PMID 18413858 DOI: 10.1096/Fj.08-106666 |
0.399 |
|
| 2008 |
Yan R, Shi Q, Hu X, Prior M, Zhou X, He W. O1-03-01: Reduced amyloid deposition in mice overexpressing RTN3 is adversely affected by preformed dystrophic neurites Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.229 |
0.37 |
|
| 2007 |
He W, Shi Q, Hu X, Yan R. The membrane topology of RTN3 and its effect on binding of RTN3 to BACE1. The Journal of Biological Chemistry. 282: 29144-51. PMID 17699523 DOI: 10.1074/Jbc.M704181200 |
0.336 |
|
| 2007 |
Hu X, Shi Q, Zhou X, He W, Yi H, Yin X, Gearing M, Levey A, Yan R. Transgenic mice overexpressing reticulon 3 develop neuritic abnormalities. The Embo Journal. 26: 2755-67. PMID 17476306 DOI: 10.1038/Sj.Emboj.7601707 |
0.493 |
|
| 2006 |
Hu X, Hicks CW, He W, Wong P, Macklin WB, Trapp BD, Yan R. Bace1 modulates myelination in the central and peripheral nervous system. Nature Neuroscience. 9: 1520-5. PMID 17099708 DOI: 10.1038/Nn1797 |
0.388 |
|
| 2006 |
He W, Hu X, Shi Q, Zhou X, Lu Y, Fisher C, Yan R. Mapping of interaction domains mediating binding between BACE1 and RTN/Nogo proteins. Journal of Molecular Biology. 363: 625-34. PMID 16979658 DOI: 10.1016/J.Jmb.2006.07.094 |
0.365 |
|
| 2006 |
Yan R, Shi Q, Hu X, Zhou X. Reticulon proteins: emerging players in neurodegenerative diseases. Cellular and Molecular Life Sciences : Cmls. 63: 877-89. PMID 16505974 DOI: 10.1007/S00018-005-5338-2 |
0.372 |
|
| 2004 |
He W, Lu Y, Qahwash I, Hu XY, Chang A, Yan R. Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation. Nature Medicine. 10: 959-65. PMID 15286784 DOI: 10.1038/Nm1088 |
0.42 |
|
| 2004 |
Qahwash I, He W, Tomasselli A, Kletzien RF, Yan R. Processing amyloid precursor protein at the beta-site requires proper orientation to be accessed by BACE1. The Journal of Biological Chemistry. 279: 39010-6. PMID 15234966 DOI: 10.1074/Jbc.M407101200 |
0.345 |
|
| 2004 |
Li R, Lindholm K, Yang LB, Yue X, Citron M, Yan R, Beach T, Sue L, Sabbagh M, Cai H, Wong P, Price D, Shen Y. Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients. Proceedings of the National Academy of Sciences of the United States of America. 101: 3632-7. PMID 14978286 DOI: 10.1073/pnas.0205689101 |
0.344 |
|
| 2003 |
Qahwash I, Weiland KL, Lu Y, Sarver RW, Kletzien RF, Yan R. Identification of a mutant amyloid peptide that predominantly forms neurotoxic protofibrillar aggregates. The Journal of Biological Chemistry. 278: 23187-95. PMID 12684519 DOI: 10.1074/jbc.M213298200 |
0.304 |
|
| 2003 |
Tomasselli AG, Qahwash I, Emmons TL, Lu Y, Leone JW, Lull JM, Fok KF, Bannow CA, Smith CW, Bienkowski MJ, Heinrikson RL, Yan R. Employing a superior BACE1 cleavage sequence to probe cellular APP processing. Journal of Neurochemistry. 84: 1006-17. PMID 12603825 DOI: 10.1046/J.1471-4159.2003.01597.X |
0.373 |
|
| 2002 |
Li J, Pauley AM, Myers RL, Shuang R, Brashler JR, Yan R, Buhl AE, Ruble C, Gurney ME. SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production. Journal of Neurochemistry. 82: 1540-8. PMID 12354302 DOI: 10.1046/J.1471-4159.2002.01105.X |
0.42 |
|
| 1999 |
Yan R, Bienkowski MJ, Shuck ME, Miao H, Tory MC, Pauley AM, Brashier JR, Stratman NC, Mathews WR, Buhl AE, Carter DB, Tomasselli AG, Parodi LA, Heinrikson RL, Gurney ME. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature. 402: 533-7. PMID 10591213 DOI: 10.1038/990107 |
0.403 |
|
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