| Year |
Citation |
Score |
| 2024 |
Mostert D, Bubeneck WA, Rauh T, Kielkowski P, Itzen A, Jung K, Sieber SA. Pronucleotide Probes Reveal a Diverging Specificity for AMPylation vs UMPylation of Human and Bacterial Nucleotide Transferases. Biochemistry. 63: 651-659. PMID 38388156 DOI: 10.1021/acs.biochem.3c00568 |
0.307 |
|
| 2023 |
Illigmann A, Vielberg MT, Lakemeyer M, Wolf F, Dema T, Stange P, Kuttenlochner W, Liebhart E, Kulik A, Staudt N, Malik I, Grond S, Sieber SA, Kaysser L, Groll M, et al. Structure of Staphylococcus aureus ClpP Bound to the Covalent Active Site Inhibitor Cystargolide A. Angewandte Chemie (International Ed. in English). e202314028. PMID 38029352 DOI: 10.1002/anie.202314028 |
0.372 |
|
| 2023 |
Dienemann JN, Chen SY, Hitzenberger M, Sievert ML, Hacker SM, Prigge ST, Zacharias M, Groll M, Sieber SA. A Chemical Proteomic Strategy Reveals Inhibitors of Lipoate Salvage in Bacteria and Parasites. Angewandte Chemie (International Ed. in English). e202304533. PMID 37249408 DOI: 10.1002/anie.202304533 |
0.308 |
|
| 2022 |
Wilkinson IVL, Castro-Falcón G, Roda-Serrat MC, Purdy TN, Straetener J, Brauny MM, Maier L, Brötz-Oesterhelt H, Christensen LP, Sieber SA, Hughes CC. The Cyanobacterial "Nutraceutical" Phycocyanobilin Inhibits Cysteine Protease Legumain. Chembiochem : a European Journal of Chemical Biology. e202200455. PMID 36538283 DOI: 10.1002/cbic.202200455 |
0.322 |
|
| 2022 |
Reinhardt L, Thomy D, Lakemeyer M, Westermann LM, Ortega J, Sieber SA, Sass P, Brötz-Oesterhelt H. Antibiotic Acyldepsipeptides Stimulate the Clp-ATPase/ClpP Complex for Accelerated Proteolysis. Mbio. e0141322. PMID 36286522 DOI: 10.1128/mbio.01413-22 |
0.323 |
|
| 2022 |
Schwarz M, Hübner I, Sieber SA. Tailored phenyl esters inhibit ClpXP and attenuate Staphylococcus aureus α-hemolysin secretion. Chembiochem : a European Journal of Chemical Biology. PMID 35713329 DOI: 10.1002/cbic.202200253 |
0.329 |
|
| 2022 |
Morimoto K, Krahn D, Kaschani F, Hopkinson-Woolley D, Gee A, Buscaill P, Mohammed S, Sieber SA, Cravatt BF, Schofield CJ, van der Hoorn RAL. Broad-range metalloprotease profiling in plants uncovers immunity provided by defence-related metalloenzyme. The New Phytologist. PMID 35510806 DOI: 10.1111/nph.18200 |
0.376 |
|
| 2022 |
Wilkinson IVL, Pfanzelt M, Sieber SA. Functionalised Cofactor Mimics for Interactome Discovery and Beyond. Angewandte Chemie (International Ed. in English). PMID 35286003 DOI: 10.1002/anie.202201136 |
0.354 |
|
| 2022 |
Pfanzelt M, Maher TE, Absmeier RM, Schwarz M, Sieber SA. Tailored Pyridoxal Probes Unravel Novel Cofactor-Dependent Targets and Antibiotic Hits in Critical Bacterial Pathogens. Angewandte Chemie (International Ed. in English). PMID 35199904 DOI: 10.1002/anie.202117724 |
0.365 |
|
| 2021 |
Hübner I, Shapiro JA, Hoßmann J, Drechsel J, Hacker SM, Rather PN, Pieper DH, Wuest WM, Sieber SA. Broad Spectrum Antibiotic Xanthocillin X Effectively Kills Dysregulation of Heme Biosynthesis. Acs Central Science. 7: 488-498. PMID 33791430 DOI: 10.1021/acscentsci.0c01621 |
0.646 |
|
| 2020 |
Macsics R, Hackl MW, Fetzer C, Mostert D, Bender J, Layer F, Sieber SA. Comparative Target Analysis of Chlorinated Biphenyl Antimicrobials Highlights MenG as Molecular Target of Triclocarban. Applied and Environmental Microbiology. PMID 32503913 DOI: 10.1128/AEM.00933-20 |
0.342 |
|
| 2020 |
Lee KM, Le P, Sieber SA, Hacker SM. Degrasyn exhibits antibiotic activity against multi-resistant Staphylococcus aureus by modifying several essential cysteines. Chemical Communications (Cambridge, England). PMID 32039420 DOI: 10.1039/c9cc09204h |
0.333 |
|
| 2019 |
Le P, Kunold E, Macsics R, Rox K, Jennings MC, Ugur I, Reinecke M, Chaves-Moreno D, Hackl MW, Fetzer C, Mandl FAM, Lehmann J, Korotkov VS, Hacker SM, Kuster B, ... ... Sieber SA, et al. Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms. Nature Chemistry. PMID 31844194 DOI: 10.1038/S41557-019-0378-7 |
0.64 |
|
| 2019 |
Zhao W, Cross AR, Crowe-McAuliffe C, Weigert-Munoz A, Csatary EE, Solinski A, Krysiak J, Goldberg J, Wilson D, Medina E, Wuest W, Sieber SA. The natural product elegaphenone potentiates antibiotic effects against Pseudomonas aeruginosa. Angewandte Chemie (International Ed. in English). PMID 30969469 DOI: 10.1002/Anie.201903472 |
0.797 |
|
| 2018 |
Falcón García C, Stangl F, Götz A, Zhao W, Sieber SA, Opitz M, Lieleg O. Topographical alterations render bacterial biofilms susceptible to chemical and mechanical stress. Biomaterials Science. 7: 220-232. PMID 30426979 DOI: 10.1039/c8bm00987b |
0.766 |
|
| 2018 |
Hoegl A, Nodwell MB, Kirsch VC, Bach NC, Pfanzelt M, Stahl M, Schneider S, Sieber SA. Mining the cellular inventory of pyridoxal phosphate-dependent enzymes with functionalized cofactor mimics. Nature Chemistry. PMID 30297752 DOI: 10.1038/s41557-018-0144-2 |
0.325 |
|
| 2018 |
Stahl M, Korotkov V, Balogh D, Kick L, Gersch M, Pahl A, Kielkowski P, Richter K, Schneider S, Sieber SA. Selective Activation of Human Caseinolytic Protease P (ClpP). Angewandte Chemie (International Ed. in English). PMID 30129683 DOI: 10.1002/Anie.201808189 |
0.724 |
|
| 2018 |
Lakemeyer M, Zhao W, Mandl FA, Hammann P, Sieber SA. Thinking Outside the Box-Novel Antibacterials To Tackle the Resistance Crisis. Angewandte Chemie (International Ed. in English). 57: 14440-14475. PMID 29939462 DOI: 10.1002/anie.201804971 |
0.78 |
|
| 2018 |
Giglio KM, Keohane CE, Stodghill PV, Steele AD, Fetzer C, Sieber SA, Filiatrault MJ, Wuest WM. Transcriptomic Profiling Suggests That Promysalin Alters the Metabolic Flux, Motility, and Iron Regulation in Pseudomonas putida KT2440. Acs Infectious Diseases. PMID 29801413 DOI: 10.1021/Acsinfecdis.8B00041 |
0.579 |
|
| 2018 |
Hofbauer B, Vomacka J, Stahl M, Korotkov VS, Jennings MC, Wuest W, Sieber SA. A dual inhibitor of Staphylococcus aureus virulence and biofilm attenuates expression of major toxins and adhesins. Biochemistry. PMID 29451388 DOI: 10.1021/Acs.Biochem.7B01271 |
0.633 |
|
| 2018 |
Keohane C, Steele A, Fetzer C, Khowsathit J, Van Tyne D, Moynie L, Gilmore MS, Karanicolas J, Sieber SA, Wuest WM. Promysalin Elicits Species-Selective Inhibition of Pseudomonas aeruginosa by Targeting Succinate Dehydrogenase. Journal of the American Chemical Society. PMID 29300464 DOI: 10.1021/Jacs.7B11212 |
0.654 |
|
| 2017 |
Fetzer C, Korotkov VS, Thänert R, Lee KM, Neuenschwander M, von Kries JP, Medina E, Sieber SA. A Chemical Disruptor of the ClpX Chaperone Complex Attenuates Multiresistant Staphylococcus aureus Virulence. Angewandte Chemie (International Ed. in English). PMID 28906057 DOI: 10.1002/anie.201708454 |
0.327 |
|
| 2017 |
Balogh D, Dahmen M, Stahl M, Poreba M, Gersch M, Drag M, Sieber SA. Insights into ClpXP proteolysis: heterooligomerization and partial deactivation enhance chaperone affinity and substrate turnover in Listeria monocytogenes. Chemical Science. 8: 1592-1600. PMID 28451288 DOI: 10.1039/C6Sc03438A |
0.746 |
|
| 2017 |
Wright MH, Fetzer C, Sieber SA. Chemical probes unravel an antimicrobial defense response triggered by binding of the human opioid dynorphin to a bacterial sensor kinase. Journal of the American Chemical Society. PMID 28350441 DOI: 10.1021/Jacs.7B01072 |
0.666 |
|
| 2017 |
Krysiak J, Sieber SA. Activity-Based Protein Profiling in Bacteria. Methods in Molecular Biology (Clifton, N.J.). 1491: 57-74. PMID 27778281 DOI: 10.1007/978-1-4939-6439-0_5 |
0.38 |
|
| 2016 |
Mandl FA, Kirsch VC, Ugur I, Kunold E, Vomacka J, Fetzer C, Schneider S, Richter K, Fuchs TM, Antes I, Sieber SA. Natural-Product-Inspired Aminoepoxybenzoquinones Kill Members of the Gram-Negative Pathogen Salmonella by Attenuating Cellular Stress Response. Angewandte Chemie (International Ed. in English). PMID 27782347 DOI: 10.1002/Anie.201607338 |
0.355 |
|
| 2016 |
Zhao W, Lorenz N, Jung K, Sieber SA. Mechanistic analysis of aliphatic β-lactones in Vibrio harveyi reveals a quorum sensing independent mode of action. Chemical Communications (Cambridge, England). 52: 11971-11974. PMID 27709214 DOI: 10.1039/c6cc05807h |
0.774 |
|
| 2016 |
Bolz C, Bach NC, Meyer H, Müller G, Dawidowski M, Popowicz G, Sieber SA, Skerra A, Gerhard M. Comparison of enzymatic properties and small molecule inhibition of γ-glutamyltranspeptidases from pathogenic and commensal bacteria. Biological Chemistry. PMID 27636829 DOI: 10.1515/Hsz-2016-0198 |
0.306 |
|
| 2016 |
Lehmann J, Wright MH, Sieber SA. Making a Long Journey Short: Alkyne Functionalization of Natural Product Scaffolds. Chemistry (Weinheim An Der Bergstrasse, Germany). 22: 4666-78. PMID 26752308 DOI: 10.1002/Chem.201504419 |
0.679 |
|
| 2016 |
Vomacka J, Korotkov VS, Bauer B, Weinandy F, Kunzmann MH, Krysiak J, Baron O, Böttcher T, Lorenz-Baath K, Sieber SA. An Aromatic Hydroxyamide Attenuates Multiresistant Staphylococcus aureus Toxin Expression. Chemistry (Weinheim An Der Bergstrasse, Germany). 22: 1622-30. PMID 26748534 DOI: 10.1002/chem.201503981 |
0.704 |
|
| 2016 |
Gersch M, Stahl M, Poreba M, Dahmen M, Dziedzic A, Drag M, Sieber SA. Barrel-shaped ClpP Proteases Display Attenuated Cleavage Specificities. Acs Chemical Biology. 11: 389-99. PMID 26606371 DOI: 10.1021/Acschembio.5B00757 |
0.735 |
|
| 2016 |
Lehmann J, Wright MH, Sieber SA. Making a Long Journey Short: Alkyne Functionalization of Natural Product Scaffolds Chemistry - a European Journal. DOI: 10.1002/chem.201504419 |
0.615 |
|
| 2016 |
Vomacka J, Korotkov VS, Bauer B, Weinandy F, Kunzmann MH, Krysiak J, Baron O, Böttcher T, Lorenz-Baath K, Sieber SA. An Aromatic Hydroxyamide Attenuates Multiresistant Staphylococcus aureus Toxin Expression Chemistry - a European Journal. 22: 1622-1630. DOI: 10.1002/chem.201503981 |
0.643 |
|
| 2015 |
Zhao W, Lorenz N, Jung K, Sieber SA. Fimbrolide Natural Products Disrupt Bioluminescence of Vibrio By Targeting Autoinducer Biosynthesis and Luciferase Activity. Angewandte Chemie (International Ed. in English). PMID 26609793 DOI: 10.1002/anie.201508052 |
0.8 |
|
| 2015 |
Hackl MW, Lakemeyer M, Dahmen M, Glaser M, Pahl A, Lorenz-Baath K, Menzel T, Sievers S, Böttcher T, Antes I, Waldmann H, Sieber SA. Phenyl Esters Are Potent Inhibitors of Caseinolytic Protease P and Reveal a Stereogenic Switch for Deoligomerization. Journal of the American Chemical Society. PMID 26083639 DOI: 10.1021/Jacs.5B03084 |
0.728 |
|
| 2015 |
Gersch M, Hackl MW, Dubiella C, Dobrinevski A, Groll M, Sieber SA. A mass spectrometry platform for a streamlined investigation of proteasome integrity, posttranslational modifications, and inhibitor binding. Chemistry & Biology. 22: 404-11. PMID 25728267 DOI: 10.1016/J.Chembiol.2015.01.004 |
0.711 |
|
| 2015 |
Gersch M, Famulla K, Dahmen M, Göbl C, Malik I, Richter K, Korotkov VS, Sass P, Rübsamen-Schaeff H, Madl T, Brötz-Oesterhelt H, Sieber SA. AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control. Nature Communications. 6: 6320. PMID 25695750 DOI: 10.1038/Ncomms7320 |
0.739 |
|
| 2015 |
Rudolf GC, Koch MF, Mandl FA, Sieber SA. Subclass-specific labeling of protein-reactive natural products with customized nucleophilic probes. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 3701-7. PMID 25605563 DOI: 10.1002/chem.201405009 |
0.301 |
|
| 2015 |
Artola M, Ruiz-Avila LB, Vergoñós A, Huecas S, Araujo-Bazán L, Martín-Fontecha M, Vázquez-Villa H, Turrado C, Ramírez-Aportela E, Hoegl A, Nodwell M, Barasoain I, Chacón P, Sieber SA, Andreu JM, et al. Effective GTP-replacing FtsZ inhibitors and antibacterial mechanism of action. Acs Chemical Biology. 10: 834-43. PMID 25486266 DOI: 10.1021/Cb500974D |
0.35 |
|
| 2014 |
Dubiella C, Cui H, Gersch M, Brouwer AJ, Sieber SA, Krüger A, Liskamp RM, Groll M. Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site. Angewandte Chemie (International Ed. in English). 53: 11969-73. PMID 25244435 DOI: 10.1002/Anie.201406964 |
0.725 |
|
| 2014 |
Weinandy F, Lorenz-Baath K, Korotkov VS, Böttcher T, Sethi S, Chakraborty T, Sieber SA. A β-lactone-based antivirulence drug ameliorates Staphylococcus aureus skin infections in mice. Chemmedchem. 9: 710-3. PMID 24678014 DOI: 10.1002/cmdc.201300325 |
0.666 |
|
| 2014 |
Kolb R, Bach NC, Sieber SA. β-Sultams exhibit discrete binding preferences for diverse bacterial enzymes with nucleophilic residues. Chemical Communications (Cambridge, England). 50: 427-9. PMID 24251314 DOI: 10.1039/c3cc46002a |
0.311 |
|
| 2014 |
Gersch M, Kolb R, Alte F, Groll M, Sieber SA. Disruption of oligomerization and dehydroalanine formation as mechanisms for ClpP protease inhibition. Journal of the American Chemical Society. 136: 1360-6. PMID 24106749 DOI: 10.1021/Ja4082793 |
0.751 |
|
| 2013 |
Wolf EV, Zeißler A, Vosyka O, Zeiler E, Sieber S, Verhelst SH. A new class of rhomboid protease inhibitors discovered by activity-based fluorescence polarization. Plos One. 8: e72307. PMID 23991088 DOI: 10.1371/Journal.Pone.0072307 |
0.424 |
|
| 2013 |
Zeiler E, List A, Alte F, Gersch M, Wachtel R, Poreba M, Drag M, Groll M, Sieber SA. Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad. Proceedings of the National Academy of Sciences of the United States of America. 110: 11302-7. PMID 23798410 DOI: 10.1073/Pnas.1219125110 |
0.749 |
|
| 2013 |
Gersch M, Gut F, Korotkov VS, Lehmann J, Böttcher T, Rusch M, Hedberg C, Waldmann H, Klebe G, Sieber SA. The mechanism of caseinolytic protease (ClpP) inhibition. Angewandte Chemie (International Ed. in English). 52: 3009-14. PMID 23361916 DOI: 10.1002/Anie.201204690 |
0.761 |
|
| 2013 |
Battenberg OA, Yang Y, Verhelst SH, Sieber SA. Target profiling of 4-hydroxyderricin in S. aureus reveals seryl-tRNA synthetase binding and inhibition by covalent modification. Molecular Biosystems. 9: 343-51. PMID 23295910 DOI: 10.1039/c2mb25446h |
0.351 |
|
| 2012 |
Nodwell MB, Menz H, Kirsch SF, Sieber SA. Rugulactone and its analogues exert antibacterial effects through multiple mechanisms including inhibition of thiamine biosynthesis. Chembiochem : a European Journal of Chemical Biology. 13: 1439-46. PMID 22653914 DOI: 10.1002/Cbic.201200265 |
0.353 |
|
| 2012 |
Gersch M, Kreuzer J, Sieber SA. Electrophilic natural products and their biological targets. Natural Product Reports. 29: 659-82. PMID 22504336 DOI: 10.1039/C2Np20012K |
0.744 |
|
| 2012 |
Gersch M, List A, Groll M, Sieber SA. Insights into structural network responsible for oligomerization and activity of bacterial virulence regulator caseinolytic protease P (ClpP) protein. The Journal of Biological Chemistry. 287: 9484-94. PMID 22291011 DOI: 10.1074/Jbc.M111.336222 |
0.735 |
|
| 2012 |
Zeiler E, Korotkov VS, Lorenz-Baath K, Böttcher T, Sieber SA. Development and characterization of improved β-lactone-based anti-virulence drugs targeting ClpP. Bioorganic & Medicinal Chemistry. 20: 583-91. PMID 21855356 DOI: 10.1016/j.bmc.2011.07.047 |
0.705 |
|
| 2012 |
Pitscheider M, Mäusbacher N, Sieber SA. Antibiotic activity and target discovery of three-membered natural product-derived heterocycles in pathogenic bacteria Chemical Science. 3: 2035-2041. DOI: 10.1039/C2Sc20290E |
0.809 |
|
| 2012 |
Böttcher T, Sieber SA. β-Lactams and β-lactones as activity-based probes in chemical biology Medchemcomm. 3: 408-417. DOI: 10.1039/c2md00275b |
0.647 |
|
| 2011 |
Zeiler E, Braun N, Böttcher T, Kastenmüller A, Weinkauf S, Sieber SA. Vibralactone as a tool to study the activity and structure of the ClpP1P2 complex from Listeria monocytogenes. Angewandte Chemie (International Ed. in English). 50: 11001-4. PMID 21954175 DOI: 10.1002/anie.201104391 |
0.665 |
|
| 2011 |
Rusch M, Zimmermann TJ, Bürger M, Dekker FJ, Görmer K, Triola G, Brockmeyer A, Janning P, Böttcher T, Sieber SA, Vetter IR, Hedberg C, Waldmann H. Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M. Angewandte Chemie (International Ed. in English). 50: 9838-42. PMID 21905186 DOI: 10.1002/Anie.201102967 |
0.667 |
|
| 2011 |
Eirich J, Orth R, Sieber SA. Unraveling the protein targets of vancomycin in living S. aureus and E. faecalis cells. Journal of the American Chemical Society. 133: 12144-53. PMID 21736328 DOI: 10.1021/ja2039979 |
0.327 |
|
| 2011 |
Geiger SR, Böttcher T, Sieber SA, Cramer P. A conformational switch underlies ClpP protease function. Angewandte Chemie (International Ed. in English). 50: 5749-52. PMID 21544912 DOI: 10.1002/anie.201100666 |
0.631 |
|
| 2011 |
Kunzmann MH, Staub I, Böttcher T, Sieber SA. Protein reactivity of natural product-derived γ-butyrolactones. Biochemistry. 50: 910-6. PMID 21188974 DOI: 10.1021/bi101858g |
0.727 |
|
| 2010 |
Gersch M, Sieber SA. Disarming Clostridium difficile. Chemistry & Biology. 17: 1165-6. PMID 21095563 DOI: 10.1016/J.Chembiol.2010.11.003 |
0.719 |
|
| 2010 |
Orth R, Böttcher T, Sieber SA. The biological targets of acivicin inspired 3-chloro- and 3-bromodihydroisoxazole scaffolds. Chemical Communications (Cambridge, England). 46: 8475-7. PMID 20936198 DOI: 10.1039/c0cc02825h |
0.682 |
|
| 2010 |
Rathore S, Sinha D, Asad M, Böttcher T, Afrin F, Chauhan VS, Gupta D, Sieber SA, Mohmmed A. A cyanobacterial serine protease of Plasmodium falciparum is targeted to the apicoplast and plays an important role in its growth and development. Molecular Microbiology. 77: 873-90. PMID 20545854 DOI: 10.1111/j.1365-2958.2010.07251.x |
0.687 |
|
| 2010 |
Böttcher T, Sieber SA. Showdomycin as a versatile chemical tool for the detection of pathogenesis-associated enzymes in bacteria. Journal of the American Chemical Society. 132: 6964-72. PMID 20433172 DOI: 10.1021/ja909150y |
0.72 |
|
| 2010 |
Böttcher T, Pitscheider M, Sieber SA. Natural products and their biological targets: proteomic and metabolomic labeling strategies. Angewandte Chemie (International Ed. in English). 49: 2680-98. PMID 20333627 DOI: 10.1002/Anie.200905352 |
0.796 |
|
| 2010 |
Orth R, Pitscheider M, Sieber SA. Chemical Probes for Labeling of the Bacterial Glucosaminidase NagZ via the Huisgen Cycloaddition Synthesis. 2010: 2201-2206. DOI: 10.1055/S-0029-1218818 |
0.793 |
|
| 2009 |
Pitscheider M, Sieber SA. Cinnamic aldehyde derived probes for the active site labelling of pathogenesis associated enzymes. Chemical Communications (Cambridge, England). 3741-3. PMID 19557267 DOI: 10.1039/B905527D |
0.792 |
|
| 2009 |
Böttcher T, Sieber SA. Beta-lactones decrease the intracellular virulence of Listeria monocytogenes in macrophages. Chemmedchem. 4: 1260-3. PMID 19472261 DOI: 10.1002/cmdc.200900157 |
0.626 |
|
| 2009 |
Staub I, Sieber SA. Beta-lactam probes as selective chemical-proteomic tools for the identification and functional characterization of resistance associated enzymes in MRSA. Journal of the American Chemical Society. 131: 6271-6. PMID 19354235 DOI: 10.1021/ja901304n |
0.34 |
|
| 2009 |
Böttcher T, Sieber SA. Structurally refined beta-lactones as potent inhibitors of devastating bacterial virulence factors. Chembiochem : a European Journal of Chemical Biology. 10: 663-6. PMID 19206121 DOI: 10.1002/cbic.200800743 |
0.693 |
|
| 2008 |
Böttcher T, Sieber SA. Beta-lactones as specific inhibitors of ClpP attenuate the production of extracellular virulence factors of Staphylococcus aureus. Journal of the American Chemical Society. 130: 14400-1. PMID 18847196 DOI: 10.1021/ja8051365 |
0.729 |
|
| 2008 |
Staub I, Sieber SA. Beta-lactams as selective chemical probes for the in vivo labeling of bacterial enzymes involved in cell wall biosynthesis, antibiotic resistance, and virulence. Journal of the American Chemical Society. 130: 13400-9. PMID 18781750 DOI: 10.1021/ja803349j |
0.34 |
|
| 2008 |
Böttcher T, Sieber SA. Beta-lactones as privileged structures for the active-site labeling of versatile bacterial enzyme classes. Angewandte Chemie (International Ed. in English). 47: 4600-3. PMID 18383487 DOI: 10.1002/anie.200705768 |
0.69 |
|
| 2006 |
Sieber SA, Cravatt BF. Analytical platforms for activity-based protein profiling--exploiting the versatility of chemistry for functional proteomics. Chemical Communications (Cambridge, England). 2311-9. PMID 16733565 DOI: 10.1039/B600653C |
0.478 |
|
| 2006 |
Sieber SA, Niessen S, Hoover HS, Cravatt BF. Proteomic profiling of metalloprotease activities with cocktails of active-site probes. Nature Chemical Biology. 2: 274-81. PMID 16565715 DOI: 10.1038/Nchembio781 |
0.515 |
|
| 2006 |
Balakrishnan A, Patel B, Sieber SA, Chen D, Pachikara N, Zhong G, Cravatt BF, Fan H. Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium. The Journal of Biological Chemistry. 281: 16691-9. PMID 16565079 DOI: 10.1074/Jbc.M513648200 |
0.512 |
|
| 2006 |
Wagner B, Sieber SA, Baumann M, Marahiel MA. Solvent engineering substantially enhances the chemoenzymatic production of surfactin. Chembiochem : a European Journal of Chemical Biology. 7: 595-7. PMID 16485318 DOI: 10.1002/Cbic.200500495 |
0.448 |
|
| 2005 |
Grünewald J, Kopp F, Mahlert C, Linne U, Sieber SA, Marahiel MA. Fluorescence resonance energy transfer as a probe of peptide cyclization catalyzed by nonribosomal thioesterase domains. Chemistry & Biology. 12: 873-81. PMID 16125099 DOI: 10.1016/J.Chembiol.2005.05.019 |
0.496 |
|
| 2005 |
Mahlert C, Sieber SA, Grünewald J, Marahiel MA. Chemoenzymatic approach to enantiopure streptogramin B variants: characterization of stereoselective pristinamycin I cyclase from Streptomyces pristinaespiralis. Journal of the American Chemical Society. 127: 9571-80. PMID 15984884 DOI: 10.1021/Ja051254T |
0.54 |
|
| 2005 |
Sieber SA, Marahiel MA. Molecular mechanisms underlying nonribosomal peptide synthesis: approaches to new antibiotics. Chemical Reviews. 105: 715-38. PMID 15700962 DOI: 10.1021/Cr0301191 |
0.485 |
|
| 2005 |
Sieber SA, Mondala TS, Head SR, Cravatt BF. Microarray Platform for Profiling Enzyme Activities in Complex Proteomes [J. Am. Chem. Soc.2004,126, 15640−15641]. Journal of the American Chemical Society. 127: 4114-4114. DOI: 10.1021/Ja0506915 |
0.425 |
|
| 2004 |
Grünewald J, Sieber SA, Mahlert C, Linne U, Marahiel MA. Synthesis and derivatization of daptomycin: a chemoenzymatic route to acidic lipopeptide antibiotics. Journal of the American Chemical Society. 126: 17025-31. PMID 15612741 DOI: 10.1021/Ja045455T |
0.508 |
|
| 2004 |
Sieber SA, Mondala TS, Head SR, Cravatt BF. Microarray platform for profiling enzyme activities in complex proteomes Journal of the American Chemical Society. 126: 15640-15641. PMID 15571375 DOI: 10.1021/JA044286+ |
0.467 |
|
| 2004 |
Garbe D, Sieber SA, Bandur NG, Koert U, Marahiel MA. Enzymatic cyclisation of peptidomimetics with incorporated (E)-alkene dipeptide isosteres. Chembiochem : a European Journal of Chemical Biology. 5: 1000-3. PMID 15239060 DOI: 10.1002/Cbic.200400042 |
0.412 |
|
| 2004 |
Grünewald J, Sieber SA, Marahiel MA. Chemo- and regioselective peptide cyclization triggered by the N-terminal fatty acid chain length: the recombinant cyclase of the calcium-dependent antibiotic from Streptomyces coelicolor. Biochemistry. 43: 2915-25. PMID 15005627 DOI: 10.1021/Bi036140D |
0.508 |
|
| 2004 |
Sieber SA, Tao J, Walsh CT, Marahiel MA. Peptidyl thiophenols as substrates for nonribosomal peptide cyclases. Angewandte Chemie (International Ed. in English). 43: 493-8. PMID 14735544 DOI: 10.1002/Anie.200352787 |
0.548 |
|
| 2003 |
Sieber SA, Marahiel MA. Learning from nature's drug factories: nonribosomal synthesis of macrocyclic peptides. Journal of Bacteriology. 185: 7036-43. PMID 14645262 DOI: 10.1128/Jb.185.24.7036-7043.2003 |
0.494 |
|
| 2003 |
Clugston SL, Sieber SA, Marahiel MA, Walsh CT. Chirality of peptide bond-forming condensation domains in nonribosomal peptide synthetases: the C5 domain of tyrocidine synthetase is a (D)C(L) catalyst. Biochemistry. 42: 12095-104. PMID 14556641 DOI: 10.1021/BI035090+ |
0.519 |
|
| 2003 |
Sieber SA, Walsh CT, Marahiel MA. Loading peptidyl-coenzyme A onto peptidyl carrier proteins: a novel approach in characterizing macrocyclization by thioesterase domains. Journal of the American Chemical Society. 125: 10862-6. PMID 12952465 DOI: 10.1021/Ja0361852 |
0.607 |
|
| 2002 |
Tseng CC, Bruner SD, Kohli RM, Marahiel MA, Walsh CT, Sieber SA. Characterization of the surfactin synthetase C-terminal thioesterase domain as a cyclic depsipeptide synthase. Biochemistry. 41: 13350-9. PMID 12416979 DOI: 10.1021/Bi026592A |
0.784 |
|
| 2002 |
Sieber SA, Linne U, Hillson NJ, Roche E, Walsh CT, Marahiel MA. Evidence for a monomeric structure of nonribosomal Peptide synthetases. Chemistry & Biology. 9: 997-1008. PMID 12323374 DOI: 10.1016/S1074-5521(02)00214-4 |
0.742 |
|
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