| Year |
Citation |
Score |
| 2023 |
Kanjo K, Chattopadhyay G, Malladi SK, Singh R, Jayatheertha S, Varadarajan R. Biophysical Correlates of Enhanced Immunogenicity of a Stabilized Variant of the Receptor Binding Domain of SARS-CoV-2. The Journal of Physical Chemistry. B. 127: 1704-1714. PMID 36790910 DOI: 10.1021/acs.jpcb.2c07262 |
0.795 |
|
| 2023 |
Chandra S, Manjunath K, Asok A, Varadarajan R. Mutational scan inferred binding energetics and structure in intrinsically disordered protein CcdA. Protein Science : a Publication of the Protein Society. e4580. PMID 36714997 DOI: 10.1002/pro.4580 |
0.369 |
|
| 2022 |
Chattopadhyay G, Ahmed S, Srilatha NS, Asok A, Varadarajan R. Ter-Seq: A high-throughput method to stabilize transient ternary complexes and measure associated kinetics. Protein Science : a Publication of the Protein Society. e4514. PMID 36382921 DOI: 10.1002/pro.4514 |
0.789 |
|
| 2022 |
Ahmed S, Chattopadhyay G, Manjunath K, Bhasin M, Singh N, Rasool M, Das S, Rana V, Khan N, Mitra D, Asok A, Singh R, Varadarajan R. Combining cysteine scanning with chemical labeling to map protein-protein interactions and infer bound structure in an intrinsically disordered region. Frontiers in Molecular Biosciences. 9: 997653. PMID 36275627 DOI: 10.3389/fmolb.2022.997653 |
0.798 |
|
| 2022 |
Chattopadhyay G, Bhowmick J, Manjunath K, Ahmed S, Goyal P, Varadarajan R. Mechanistic insights into global suppressors of protein folding defects. Plos Genetics. 18: e1010334. PMID 36037221 DOI: 10.1371/journal.pgen.1010334 |
0.787 |
|
| 2022 |
Bajaj P, Manjunath K, Varadarajan R. Structural and functional determinants inferred from deep mutational scans. Protein Science : a Publication of the Protein Society. 31: e4357. PMID 35762712 DOI: 10.1002/pro.4357 |
0.393 |
|
| 2022 |
Khatri B, Pramanick I, Malladi SK, Rajmani RS, Kumar S, Ghosh P, Sengupta N, Rahisuddin R, Kumar N, Kumaran S, Ringe RP, Varadarajan R, Dutta S, Chatterjee J. A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein. Nature Chemical Biology. PMID 35654847 DOI: 10.1038/s41589-022-01060-0 |
0.345 |
|
| 2022 |
Chattopadhyay G, Bhasin M, Ahmed S, Gosain TP, Ganesan S, Das S, Thakur C, Chandra N, Singh R, Varadarajan R. Functional and Biochemical Characterization of the MazEF6 Toxin-Antitoxin System of Mycobacterium tuberculosis. Journal of Bacteriology. e0005822. PMID 35357163 DOI: 10.1128/jb.00058-22 |
0.763 |
|
| 2022 |
Ahmed S, Manjunath K, Chattopadhyay G, Varadarajan R. Identification of stabilizing point mutations through mutagenesis of destabilized protein libraries. The Journal of Biological Chemistry. 298: 101785. PMID 35247389 DOI: 10.1016/j.jbc.2022.101785 |
0.782 |
|
| 2022 |
Ahmed S, Bhasin M, Manjunath K, Varadarajan R. Prediction of Residue-specific Contributions to Binding and Thermal Stability Using Yeast Surface Display. Frontiers in Molecular Biosciences. 8: 800819. PMID 35127820 DOI: 10.3389/fmolb.2021.800819 |
0.38 |
|
| 2021 |
Chandra S, Chattopadhyay G, Varadarajan R. Rapid Identification of Secondary Structure and Binding Site Residues in an Intrinsically Disordered Protein Segment. Frontiers in Genetics. 12: 755292. PMID 34795695 DOI: 10.3389/fgene.2021.755292 |
0.789 |
|
| 2020 |
Sharma A, Chattopadhyay G, Chopra P, Bhasin M, Thakur C, Agarwal S, Ahmed S, Chandra N, Varadarajan R, Singh R. VapC21 Toxin Contributes to Drug-Tolerance and Interacts With Non-cognate VapB32 Antitoxin in . Frontiers in Microbiology. 11: 2037. PMID 33042034 DOI: 10.3389/Fmicb.2020.02037 |
0.752 |
|
| 2020 |
Das R, Datta R, Varadarajan R. Probing the structure of the HIV-1 Envelope trimer using Aspartate Scanning Mutagenesis. Journal of Virology. PMID 32817217 DOI: 10.1128/Jvi.01426-20 |
0.411 |
|
| 2020 |
Agarwal S, Sharma A, Bouzeyen R, Deep A, Sharma H, Mangalaparthi KK, Datta KK, Kidwai S, Gowda H, Varadarajan R, Sharma RD, Thakur KG, Singh R. VapBC22 toxin-antitoxin system from is required for pathogenesis and modulation of host immune response. Science Advances. 6: eaba6944. PMID 32537511 DOI: 10.1126/Sciadv.Aba6944 |
0.349 |
|
| 2020 |
Aghera NK, Prabha J, Tandon H, Chattopadhyay G, Vishwanath S, Srinivasan N, Varadarajan R. Mechanism of CcdA-Mediated Rejuvenation of DNA Gyrase. Structure (London, England : 1993). PMID 32294467 DOI: 10.1016/J.Str.2020.03.006 |
0.769 |
|
| 2020 |
Nickolaus C, Vargas C, Reichenwallner J, Chakour M, Selmke B, Chakraborty R, Varadarajan R, Keller S, Trommer WE. The Molten Globule State of Maltose-Binding Protein: Structural and Thermodynamic Characterization by EPR Spectroscopy and Isothermal Titration Calorimetry Applied Magnetic Resonance. 51: 877-886. DOI: 10.1007/S00723-020-01232-Y |
0.306 |
|
| 2019 |
Tandon H, Sharma A, Wadhwa S, Varadarajan R, Singh R, Srinivasan DN, Sandhya S. Bioinformatic and mutational studies of related toxin-antitoxin pairs in predict and identify key functional residues. The Journal of Biological Chemistry. PMID 31018964 DOI: 10.1074/Jbc.Ra118.006814 |
0.356 |
|
| 2019 |
Chattopadhyay G, Varadarajan R. Facile measurement of protein stability and folding kinetics using a nano differential scanning fluorimeter. Protein Science : a Publication of the Protein Society. PMID 30993730 DOI: 10.1002/Pro.3622 |
0.781 |
|
| 2019 |
Tripathi A, Swaroop S, Varadarajan R. Molecular Determinants of Temperature-Sensitive Phenotypes. Biochemistry. 58: 1738-1750. PMID 30843689 DOI: 10.1021/Acs.Biochem.8B00964 |
0.46 |
|
| 2019 |
Baliga C, Selmke B, Worobiew I, Borbat P, Sarma SP, Trommer WE, Varadarajan R, Aghera N. CcdB at pH 4 Forms a Partially Unfolded State with a Dry Core. Biophysical Journal. PMID 30777307 DOI: 10.1016/J.Bpj.2019.01.026 |
0.337 |
|
| 2019 |
Khare S, Bhasin M, Sahoo A, Varadarajan R. Protein model discrimination attempts using mutational sensitivity, predicted secondary structure, and model quality information. Proteins. PMID 30615225 DOI: 10.1002/Prot.25654 |
0.38 |
|
| 2018 |
Purwar M, Pokorski JK, Singh P, Bhattacharyya S, Arendt H, DeStefano J, La Branche CC, Montefiori DC, Finn MG, Varadarajan R. Design, display and immunogenicity of HIV1 gp120 fragment immunogens on virus-like particles. Vaccine. PMID 30220462 DOI: 10.1016/J.Vaccine.2018.07.032 |
0.329 |
|
| 2018 |
Raghunandanan S, Ramachandran R, Gomez RL, Sivasankar D, Bommakanti A, Kondapi AK, Varadarajan R, Kumar AR. Rv0474 is a copper-responsive transcriptional regulator that negatively regulates expression of RNA polymerase β subunit in Mycobacterium tuberculosis. The Febs Journal. PMID 30120904 DOI: 10.1111/Febs.14637 |
0.32 |
|
| 2018 |
Rathore U, Purwar M, Vignesh VS, Das R, Kumar AA, Bhattacharyya S, Arendt HE, DeStefano J, Wilson A, Parks C, LaBranche CC, Montefiori DC, Varadarajan R. Bacterially expressed HIV-1 gp120 outer-domain fragment immunogens with improved stability and affinity for CD4 binding site neutralizing antibodies. The Journal of Biological Chemistry. PMID 30093409 DOI: 10.1074/Jbc.Ra118.005006 |
0.368 |
|
| 2018 |
Selmke B, Borbat PP, Nickolaus C, Varadarajan R, Freed JH, Trommer WE. Open and Closed Form of Maltose Binding Protein in Its Native and Molten Globule State as Studied by EPR Spectroscopy. Biochemistry. PMID 30004675 DOI: 10.1021/Acs.Biochem.8B00322 |
0.429 |
|
| 2018 |
Najar TA, Kar U, Flynn JA, Varadarajan R. Isolation of an in vitro affinity-matured, thermostable "Headless" HA stem fragment that binds broadly neutralizing antibodies with high affinity. Biochemistry. PMID 29863853 DOI: 10.1021/Acs.Biochem.8B00267 |
0.351 |
|
| 2018 |
Najar TA, Khare S, Varadarajan R. Rapid Mapping of Protein Binding Sites and Conformational Epitopes by Coupling Yeast Surface Display to Chemical Labeling and Deep Sequencing. Methods in Molecular Biology (Clifton, N.J.). 1785: 77-88. PMID 29714013 DOI: 10.1007/978-1-4939-7841-0_6 |
0.458 |
|
| 2018 |
Gupta K, Varadarajan R. Insights into protein structure, stability and function from saturation mutagenesis. Current Opinion in Structural Biology. 50: 117-125. PMID 29505936 DOI: 10.1016/J.Sbi.2018.02.006 |
0.47 |
|
| 2017 |
Rathore U, Saha P, Kesavardhana S, Kumar AA, Datta R, Devanarayanan S, Das R, Mascola JR, Varadarajan R. Glycosylation of the core of the HIV-1 envelope subunit protein gp120 is not required for native trimer formation or viral infectivity. The Journal of Biological Chemistry. PMID 28446609 DOI: 10.1074/Jbc.M117.788919 |
0.392 |
|
| 2017 |
Najar TA, Khare S, Pandey R, Gupta SK, Varadarajan R. Mapping Protein Binding Sites and Conformational Epitopes Using Cysteine Labeling and Yeast Surface Display. Structure (London, England : 1993). PMID 28132782 DOI: 10.1016/J.Str.2016.12.016 |
0.458 |
|
| 2016 |
Kesavardhana S, Das R, Citron M, Datta R, Ecto L, Srilatha NS, DiStefano D, Swoyer R, Joyce JG, Dutta S, LaBranche CC, Montefiori DC, Flynn JA, Varadarajan R. Structure based design of cyclically permuted HIV-1 gp120 trimers that elicit neutralizing antibodies. The Journal of Biological Chemistry. PMID 27879316 DOI: 10.1074/Jbc.M116.725614 |
0.332 |
|
| 2016 |
Vijaykrishna N, Melangath G, Kumar R, Khandelia P, Bawa P, Varadarajan R, Vijayraghavan U. The fission yeast pre-mRNA processing factor 18 (prp18+) has intron-specific splicing functions with links to G1-S cell cycle progression. The Journal of Biological Chemistry. PMID 27875300 DOI: 10.1074/Jbc.M116.751289 |
0.346 |
|
| 2016 |
Baliga C, Varadarajan R, Aghera N. Homodimeric Escherichia coli Toxin CcdB (Controller of Cell Division or Death B Protein) Folds via Parallel Pathways. Biochemistry. 55: 6019-6031. PMID 27696818 DOI: 10.1021/Acs.Biochem.6B00726 |
0.437 |
|
| 2016 |
Tripathi A, Gupta K, Khare S, Jain PC, Patel S, Kumar P, Pulianmackal AJ, Aghera N, Varadarajan R. Molecular determinants of mutant phenotypes, inferred from saturation mutagenesis data. Molecular Biology and Evolution. PMID 27563054 DOI: 10.1093/Molbev/Msw182 |
0.458 |
|
| 2016 |
Baliga C, Majhi S, Mondal K, Bhattacharjee A, VijayRaghavan K, Varadarajan R. Rational elicitation of cold-sensitive phenotypes. Proceedings of the National Academy of Sciences of the United States of America. 113: E2506-15. PMID 27091994 DOI: 10.1073/Pnas.1604190113 |
0.375 |
|
| 2016 |
Jain PC, Patel S, Kumar P, Varadarajan R. Structural and Mechanistic Insights Derived from Saturation Mutagenesis of CcdB Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.292 |
0.468 |
|
| 2015 |
Sahoo A, Khare S, Devanarayanan S, Jain P, Varadarajan R. Residue proximity information and protein model discrimination using saturation-suppressor mutagenesis. Elife. 4. PMID 26716404 DOI: 10.7554/Elife.09532 |
0.415 |
|
| 2014 |
Kesavardhana S, Varadarajan R. Stabilizing the native trimer of HIV-1 Env by destabilizing the heterodimeric interface of the gp41 postfusion six-helix bundle. Journal of Virology. 88: 9590-604. PMID 24920800 DOI: 10.1128/Jvi.00494-14 |
0.386 |
|
| 2014 |
Tan KP, Khare S, Varadarajan R, Madhusudhan MS. TSpred: a web server for the rational design of temperature-sensitive mutants. Nucleic Acids Research. 42: W277-84. PMID 24782523 DOI: 10.1093/Nar/Gku319 |
0.437 |
|
| 2014 |
Tripathi A, Varadarajan R. Residue specific contributions to stability and activity inferred from saturation mutagenesis and deep sequencing Current Opinion in Structural Biology. 24: 63-71. PMID 24721454 DOI: 10.1016/J.Sbi.2013.12.001 |
0.454 |
|
| 2014 |
Tripathi A, Dewan PC, Siddique SA, Varadarajan R. MazF-induced growth inhibition and persister generation in Escherichia coli. The Journal of Biological Chemistry. 289: 4191-205. PMID 24375411 DOI: 10.1074/Jbc.M113.510511 |
0.303 |
|
| 2014 |
Jain PC, Varadarajan R. A rapid, efficient, and economical inverse polymerase chain reaction-based method for generating a site saturation mutant library. Analytical Biochemistry. 449: 90-8. PMID 24333246 DOI: 10.1016/J.Ab.2013.12.002 |
0.314 |
|
| 2013 |
Tan KP, Nguyen TB, Patel S, Varadarajan R, Madhusudhan MS. Depth: a web server to compute depth, cavity sizes, detect potential small-molecule ligand-binding cavities and predict the pKa of ionizable residues in proteins. Nucleic Acids Research. 41: W314-21. PMID 23766289 DOI: 10.1093/Nar/Gkt503 |
0.415 |
|
| 2013 |
Singh P, Sharma L, Kulothungan SR, Adkar BV, Prajapati RS, Ali PS, Krishnan B, Varadarajan R. Effect of signal peptide on stability and folding of Escherichia coli thioredoxin. Plos One. 8: e63442. PMID 23667620 DOI: 10.1371/Journal.Pone.0063442 |
0.358 |
|
| 2013 |
Mallajosyula VV, Citron M, Lu X, Meulen JT, Varadarajan R, Liang X. In vitro and in vivo characterization of designed immunogens derived from the CD-helix of the stem of influenza hemagglutinin. Proteins. 81: 1759-75. PMID 23625724 DOI: 10.1002/Prot.24317 |
0.325 |
|
| 2013 |
Bhattacharyya S, Singh P, Rathore U, Purwar M, Wagner D, Arendt H, DeStefano J, LaBranche CC, Montefiori DC, Phogat S, Varadarajan R. Design of an Escherichia coli expressed HIV-1 gp120 fragment immunogen that binds to b12 and induces broad and potent neutralizing antibodies. The Journal of Biological Chemistry. 288: 9815-25. PMID 23430741 DOI: 10.1074/Jbc.M112.425959 |
0.329 |
|
| 2013 |
Shembekar N, Mallajosyula VV, Mishra A, Yeolekar L, Dhere R, Kapre S, Varadarajan R, Gupta SK. Isolation of a high affinity neutralizing monoclonal antibody against 2009 pandemic H1N1 virus that binds at the 'Sa' antigenic site. Plos One. 8: e55516. PMID 23383214 DOI: 10.1371/Journal.Pone.0055516 |
0.306 |
|
| 2013 |
Bhattacharyya S, Varadarajan R. Packing in molten globules and native states. Current Opinion in Structural Biology. 23: 11-21. PMID 23270864 DOI: 10.1016/J.Sbi.2012.10.010 |
0.471 |
|
| 2013 |
Reichenwallner J, Chakour M, Indu S, Varadarajan R, Trommer WE. Maltose Binding Protein Is Partially Structured in Its Molten Globule State Applied Magnetic Resonance. 44: 983-995. DOI: 10.1007/S00723-013-0468-4 |
0.422 |
|
| 2012 |
Bommakanti G, Lu X, Citron MP, Najar TA, Heidecker GJ, ter Meulen J, Varadarajan R, Liang X. Design of Escherichia coli-expressed stalk domain immunogens of H1N1 hemagglutinin that protect mice from lethal challenge. Journal of Virology. 86: 13434-44. PMID 23015722 DOI: 10.1128/Jvi.01429-12 |
0.324 |
|
| 2012 |
Gautam S, Dubey P, Varadarajan R, Gupta MN. Role of smart polymers in protein purification and refolding. Bioengineered. 3: 286-8. PMID 22892577 DOI: 10.4161/Bioe.21372 |
0.369 |
|
| 2012 |
Hu X, Saha P, Chen X, Kim D, Devarasetty M, Varadarajan R, Jin MM. Cell surface assembly of HIV gp41 six-helix bundles for facile, quantitative measurements of hetero-oligomeric interactions. Journal of the American Chemical Society. 134: 14642-5. PMID 22888993 DOI: 10.1021/Ja301099S |
0.337 |
|
| 2012 |
Gautam S, Dubey P, Singh P, Varadarajan R, Gupta MN. Simultaneous refolding and purification of recombinant proteins by macro-(affinity ligand) facilitated three-phase partitioning. Analytical Biochemistry. 430: 56-64. PMID 22885237 DOI: 10.1016/J.Ab.2012.07.028 |
0.394 |
|
| 2012 |
Tripathi A, Dewan PC, Barua B, Varadarajan R. Additional role for the ccd operon of F-plasmid as a transmissible persistence factor. Proceedings of the National Academy of Sciences of the United States of America. 109: 12497-502. PMID 22802647 DOI: 10.1073/Pnas.1121217109 |
0.353 |
|
| 2012 |
Gautam S, Dubey P, Singh P, Kesavardhana S, Varadarajan R, Gupta MN. Smart polymer mediated purification and recovery of active proteins from inclusion bodies. Journal of Chromatography. A. 1235: 10-25. PMID 22425208 DOI: 10.1016/J.Chroma.2012.02.048 |
0.407 |
|
| 2012 |
Saha P, Bhattacharyya S, Kesavardhana S, Miranda ER, Ali PS, Sharma D, Varadarajan R. Designed cyclic permutants of HIV-1 gp120: implications for envelope trimer structure and immunogen design. Biochemistry. 51: 1836-47. PMID 22329717 DOI: 10.1021/Bi300003V |
0.349 |
|
| 2012 |
Adkar BV, Tripathi A, Sahoo A, Bajaj K, Goswami D, Chakrabarti P, Swarnkar MK, Gokhale RS, Varadarajan R. Protein model discrimination using mutational sensitivity derived from deep sequencing. Structure (London, England : 1993). 20: 371-81. PMID 22325784 DOI: 10.1016/J.Str.2011.11.021 |
0.431 |
|
| 2011 |
Haimann MM, Akdogan Y, Philipp R, Varadarajan R, Hinderberger D, Trommer WE. Conformational changes of the chaperone SecB upon binding to a model substrate--bovine pancreatic trypsin inhibitor (BPTI). Biological Chemistry. 392: 849-58. PMID 21848506 DOI: 10.1515/Bc.2011.151 |
0.381 |
|
| 2011 |
Saha P, Barua B, Bhattacharyya S, Balamurali MM, Schief WR, Baker D, Varadarajan R. Design and characterization of stabilized derivatives of human CD4D12 and CD4D1. Biochemistry. 50: 7891-900. PMID 21827143 DOI: 10.1021/Bi200870R |
0.372 |
|
| 2011 |
Aggarwal V, Kulothungan SR, Balamurali MM, Saranya SR, Varadarajan R, Ainavarapu SR. Ligand-modulated parallel mechanical unfolding pathways of maltose-binding proteins. The Journal of Biological Chemistry. 286: 28056-65. PMID 21659518 DOI: 10.1074/Jbc.M111.249045 |
0.455 |
|
| 2011 |
Tan KP, Varadarajan R, Madhusudhan MS. DEPTH: a web server to compute depth and predict small-molecule binding cavities in proteins. Nucleic Acids Research. 39: W242-8. PMID 21576233 DOI: 10.1093/Nar/Gkr356 |
0.448 |
|
| 2011 |
Indu S, Kochat V, Thakurela S, Ramakrishnan C, Varadarajan R. Conformational analysis and design of cross-strand disulfides in antiparallel β-sheets. Proteins. 79: 244-60. PMID 21058397 DOI: 10.1002/Prot.22878 |
0.464 |
|
| 2011 |
Aggarwal V, Kulothungan S. R, Rajaram S, M.M. B, Varadarajan R, Ainavarapu SRK. Single-Molecule Studies of the Parallel Unfolding Pathways of Maltose Binding Protein (MBP) Biophysical Journal. 100: 481a. DOI: 10.1016/J.Bpj.2010.12.2821 |
0.429 |
|
| 2010 |
Bommakanti G, Citron MP, Hepler RW, Callahan C, Heidecker GJ, Najar TA, Lu X, Joyce JG, Shiver JW, Casimiro DR, ter Meulen J, Liang X, Varadarajan R. Design of an HA2-based Escherichia coli expressed influenza immunogen that protects mice from pathogenic challenge. Proceedings of the National Academy of Sciences of the United States of America. 107: 13701-6. PMID 20615991 DOI: 10.1073/Pnas.1007465107 |
0.36 |
|
| 2010 |
Bhattacharyya S, Rajan RE, Swarupa Y, Rathore U, Verma A, Udaykumar R, Varadarajan R. Design of a non-glycosylated outer domain-derived HIV-1 gp120 immunogen that binds to CD4 and induces neutralizing antibodies. The Journal of Biological Chemistry. 285: 27100-10. PMID 20558728 DOI: 10.1074/Jbc.M110.152272 |
0.342 |
|
| 2010 |
Indu S, Kumar ST, Thakurela S, Gupta M, Bhaskara RM, Ramakrishnan C, Varadarajan R. Disulfide conformation and design at helix N-termini. Proteins. 78: 1228-42. PMID 19938155 DOI: 10.1002/Prot.22641 |
0.405 |
|
| 2009 |
Kulothungan SR, Das M, Johnson M, Ganesh C, Varadarajan R. Effect of crowding agents, signal peptide, and chaperone SecB on the folding and aggregation of E. coli maltose binding protein. Langmuir : the Acs Journal of Surfaces and Colloids. 25: 6637-48. PMID 19358587 DOI: 10.1021/La900198H |
0.399 |
|
| 2009 |
Krishnan B, Kulothungan SR, Patra AK, Udgaonkar JB, Varadarajan R. SecB-mediated protein export need not occur via kinetic partitioning. Journal of Molecular Biology. 385: 1243-56. PMID 19028503 DOI: 10.1016/J.Jmb.2008.10.094 |
0.467 |
|
| 2008 |
Bajaj K, Dewan PC, Chakrabarti P, Goswami D, Barua B, Baliga C, Varadarajan R. Structural correlates of the temperature sensitive phenotype derived from saturation mutagenesis studies of CcdB. Biochemistry. 47: 12964-73. PMID 19006334 DOI: 10.1021/Bi8014345 |
0.462 |
|
| 2008 |
Raghava S, Barua B, Singh PK, Das M, Madan L, Bhattacharyya S, Bajaj K, Gopal B, Varadarajan R, Gupta MN. Refolding and simultaneous purification by three-phase partitioning of recombinant proteins from inclusion bodies. Protein Science : a Publication of the Protein Society. 17: 1987-97. PMID 18780821 DOI: 10.1110/Ps.036939.108 |
0.377 |
|
| 2008 |
Raghava S, Aquil S, Bhattacharyya S, Varadarajan R, Gupta MN. Strategy for purifying maltose binding protein fusion proteins by affinity precipitation. Journal of Chromatography. A. 1194: 90-5. PMID 18466911 DOI: 10.1016/J.Chroma.2008.04.029 |
0.409 |
|
| 2008 |
Bajaj K, Madhusudhan MS, Adkar BV, Chakrabarti P, Ramakrishnan C, Sali A, Varadarajan R. Stereochemical criteria for prediction of the effects of proline mutations on protein stability. Plos Computational Biology. 3: e241. PMID 18069886 DOI: 10.1371/Journal.Pcbi.0030241 |
0.429 |
|
| 2007 |
Mondal K, VijayRaghavan K, Varadarajan R. Design and utility of temperature-sensitive Gal4 mutants for conditional gene expression in Drosophila. Fly. 1: 282-6. PMID 18836309 DOI: 10.4161/Fly.5251 |
0.436 |
|
| 2007 |
Das M, Kobayashi M, Yamada Y, Sreeramulu S, Ramakrishnan C, Wakatsuki S, Kato R, Varadarajan R. Design of disulfide-linked thioredoxin dimers and multimers through analysis of crystal contacts. Journal of Molecular Biology. 372: 1278-92. PMID 17727880 DOI: 10.1016/J.Jmb.2007.07.033 |
0.399 |
|
| 2007 |
Prajapati RS, Indu S, Varadarajan R. Identification and thermodynamic characterization of molten globule states of periplasmic binding proteins. Biochemistry. 46: 10339-52. PMID 17696409 DOI: 10.1021/Bi700577M |
0.46 |
|
| 2007 |
Mondal K, Dastidar AG, Singh G, Madhusudhanan S, Gande SL, VijayRaghavan K, Varadarajan R. Design and isolation of temperature-sensitive mutants of Gal4 in yeast and Drosophila. Journal of Molecular Biology. 370: 939-50. PMID 17553522 DOI: 10.1016/J.Jmb.2007.05.035 |
0.414 |
|
| 2007 |
Mondal K, Raghava S, Barua B, Varadarajan R, Gupta MN. Role of stimuli-sensitive polymers in protein refolding: alpha-amylase and CcdB (controller of cell division or death B) as model proteins. Langmuir : the Acs Journal of Surfaces and Colloids. 23: 70-5. PMID 17190487 DOI: 10.1021/La0616799 |
0.353 |
|
| 2007 |
Prajapati RS, Das M, Sreeramulu S, Sirajuddin M, Srinivasan S, Krishnamurthy V, Ranjani R, Ramakrishnan C, Varadarajan R. Thermodynamic effects of proline introduction on protein stability. Proteins. 66: 480-91. PMID 17034035 DOI: 10.1002/Prot.21215 |
0.507 |
|
| 2006 |
Prajapati RS, Sirajuddin M, Durani V, Sreeramulu S, Varadarajan R. Contribution of cation-pi interactions to protein stability. Biochemistry. 45: 15000-10. PMID 17154537 DOI: 10.1021/Bi061275F |
0.417 |
|
| 2006 |
Chakraborty K, Durani V, Miranda ER, Citron M, Liang X, Schleif W, Joyce JG, Varadarajan R. Design of immunogens that present the crown of the HIV-1 V3 loop in a conformation competent to generate 447-52D-like antibodies. The Biochemical Journal. 399: 483-91. PMID 16827663 DOI: 10.1042/Bj20060588 |
0.312 |
|
| 2005 |
Sharma D, Balamurali MM, Chakraborty K, Kumaran S, Jeganathan S, Rashid U, Ingallinella P, Varadarajan R. Protein minimization of the gp120 binding region of human CD4+ Biochemistry. 44: 16192-16202. PMID 16331979 DOI: 10.1021/Bi051120S |
0.34 |
|
| 2005 |
Chakraborty K, Thakurela S, Prajapati RS, Indu S, Ali PSS, Ramakrishnan C, Varadarajan R. Protein stabilization by introduction of cross-strand disulfides Biochemistry. 44: 14638-14646. PMID 16262263 DOI: 10.1021/Bi050921S |
0.407 |
|
| 2005 |
Bajaj K, Chakrabarti P, Varadarajan R. Mutagenesis-based definitions and probes of residue burial in proteins. Proceedings of the National Academy of Sciences of the United States of America. 102: 16221-6. PMID 16251276 DOI: 10.1073/Pnas.0505089102 |
0.482 |
|
| 2005 |
Chakraborty K, Shivakumar P, Raghothama S, Varadarajan R. NMR structural analysis of a peptide mimic of the bridging sheet of HIV-1 gp120 in methanol and water Biochemical Journal. 390: 573-581. PMID 15896194 DOI: 10.1042/Bj20050442 |
0.36 |
|
| 2005 |
Das M, Rao BV, Ghosh S, Varadarajan R. Attempts to delineate the relative contributions of changes in hydrophobicity and packing to changes in stability of ribonuclease S mutants. Biochemistry. 44: 5923-30. PMID 15823052 DOI: 10.1021/BI050001+ |
0.389 |
|
| 2004 |
Bhinge A, Chakrabarti P, Uthanumallian K, Bajaj K, Chakraborty K, Varadarajan R. Accurate detection of protein:ligand binding sites using molecular dynamics simulations Structure. 12: 1989-1999. PMID 15530363 DOI: 10.1016/J.Str.2004.09.005 |
0.404 |
|
| 2004 |
Chakshusmathi G, Mondal K, Lakshmi GS, Singh G, Roy A, Ch RB, Madhusudhanan S, Varadarajan R. Design of temperature-sensitive mutants solely from amino acid sequence. Proceedings of the National Academy of Sciences of the United States of America. 101: 7925-30. PMID 15148363 DOI: 10.1073/Pnas.0402222101 |
0.421 |
|
| 2004 |
Beena K, Udgaonkar JB, Varadarajan R. Effect of signal peptide on the stability and folding kinetics of maltose binding protein. Biochemistry. 43: 3608-19. PMID 15035631 DOI: 10.1021/Bi0360509 |
0.431 |
|
| 2004 |
Bajaj K, Chakshusmathi G, Bachhawat-Sikder K, Surolia A, Varadarajan R. Thermodynamic characterization of monomeric and dimeric forms of CcdB (controller of cell division or death B protein). The Biochemical Journal. 380: 409-17. PMID 14763902 DOI: 10.1042/Bj20031528 |
0.417 |
|
| 2003 |
Prajapati RS, Lingaraju GM, Bacchawat K, Surolia A, Varadarajan R. Thermodynamic effects of replacements of Pro residues in helix interiors of maltose-binding protein. Proteins. 53: 863-71. PMID 14635128 DOI: 10.1002/Prot.10488 |
0.477 |
|
| 2003 |
Dani VS, Ramakrishnan C, Varadarajan R. MODIP revisited: re-evaluation and refinement of an automated procedure for modeling of disulfide bonds in proteins. Protein Engineering. 16: 187-93. PMID 12702798 DOI: 10.1093/Proeng/Gzg024 |
0.411 |
|
| 2003 |
Padmakumar VC, Varadarajan R. A gradient PCR-based screen for use in site-directed mutagenesis. Analytical Biochemistry. 314: 310-5. PMID 12654318 DOI: 10.1016/S0003-2697(02)00688-7 |
0.34 |
|
| 2002 |
Rudresh, Jain R, Dani V, Mitra A, Srivastava S, Sarma SP, Varadarajan R, Ramakumar S. Structural consequences of replacement of an α-helical pro residue in Escherichia coli thioredoxin Protein Engineering. 15: 627-633. PMID 12364576 DOI: 10.1093/Protein/15.8.627 |
0.347 |
|
| 2002 |
Chakravarty S, Bhinge A, Varadarajan R. A procedure for detection and quantitation of cavity volumes proteins. Application to measure the strength of the hydrophobic driving force in protein folding. The Journal of Biological Chemistry. 277: 31345-53. PMID 12070144 DOI: 10.1074/Jbc.M201373200 |
0.407 |
|
| 2002 |
Chakravarty S, Varadarajan R. Elucidation of factors responsible for enhanced thermal stability of proteins: a structural genomics based study. Biochemistry. 41: 8152-61. PMID 12069608 DOI: 10.1021/Bi025523T |
0.433 |
|
| 2001 |
Ganesh C, Zaidi FN, Udgaonkar JB, Varadarajan R. Reversible formation of on-pathway macroscopic aggregates during the folding of maltose binding protein. Protein Science : a Publication of the Protein Society. 10: 1635-44. PMID 11468360 DOI: 10.1110/Ps.8101 |
0.404 |
|
| 2001 |
Panse VG, Beena K, Philipp R, Trommer WE, Vogel PD, Varadarajan R. Electron spin resonance and fluorescence studies of the bound-state conformation of a model protein substrate to the chaperone SecB. The Journal of Biological Chemistry. 276: 33681-8. PMID 11435433 DOI: 10.1074/Jbc.M104466200 |
0.42 |
|
| 2001 |
Ratnaparkhi GS, Varadarajan R. Osmolytes stabilize ribonuclease S by stabilizing its fragments S protein and S peptide to compact folding-competent states. Journal of Biological Chemistry. 276: 28789-28798. PMID 11373282 DOI: 10.1074/Jbc.M101906200 |
0.426 |
|
| 2000 |
Ratnaparkhi GS, Awasthi SK, Rani P, Balaram P, Varadarajan R. Structural and thermodynamic consequences of introducing alpha-aminoisobutyric acid in the S peptide of ribonuclease S. Protein Engineering. 13: 697-702. PMID 11112508 DOI: 10.1093/Protein/13.10.697 |
0.38 |
|
| 2000 |
Ratnaparkhi GS, Varadarajan R. Thermodynamic and structural studies of cavity formation in proteins suggest that loss of packing interactions rather than the hydrophobic effect dominates the observed energetics. Biochemistry. 39: 12365-12374. PMID 11015216 DOI: 10.1021/Bi000775K |
0.466 |
|
| 2000 |
Chakravarty S, Mitra N, Queitsch I, Surolia A, Varadarajan R, Dübel S. Protein stabilization through phage display. Febs Letters. 476: 296-300. PMID 10913631 DOI: 10.1016/S0014-5793(00)01725-7 |
0.426 |
|
| 2000 |
Panse VG, Vogel P, Trommer WE, Varadarajan R. A thermodynamic coupling mechanism for the disaggregation of a model peptide substrate by chaperone secB. The Journal of Biological Chemistry. 275: 18698-703. PMID 10858444 DOI: 10.1074/Jbc.275.25.18698 |
0.36 |
|
| 2000 |
Chakravarty S, Varadarajan R. Elucidation of determinants of protein stability through genome sequence analysis. Febs Letters. 470: 65-69. PMID 10722847 DOI: 10.1016/S0014-5793(00)01267-9 |
0.401 |
|
| 2000 |
Panse VG, Swaminathan CP, Surolia A, Varadarajan R. Thermodynamics of substrate binding to the chaperone SecB. Biochemistry. 39: 2420-7. PMID 10694412 DOI: 10.1021/Bi992065O |
0.399 |
|
| 2000 |
Panse VG, Swaminathan CP, Aloor JJ, Surolia A, Varadarajan R. Unfolding thermodynamics of the tetrameric chaperone, SecB. Biochemistry. 39: 2362-9. PMID 10694404 DOI: 10.1021/Bi992484L |
0.38 |
|
| 1999 |
Chakrabarti A, Srivastava S, Swaminathan CP, Surolia A, Varadarajan R. Thermodynamics of replacing an alpha-helical Pro residue in the P40S mutant of Escherichia coli thioredoxin. Protein Science : a Publication of the Protein Society. 8: 2455-9. PMID 10595549 DOI: 10.1110/Ps.8.11.2455 |
0.412 |
|
| 1999 |
Sheshadri S, Lingaraju GM, Varadarajan R. Denaturant mediated unfolding of both native and molten globule states of maltose binding protein are accompanied by large deltaCp's. Protein Science : a Publication of the Protein Society. 8: 1689-95. PMID 10452613 DOI: 10.1110/Ps.8.8.1689 |
0.397 |
|
| 1999 |
Ganesh C, Banerjee A, Shah A, Varadarajan R. Disordered N-terminal residues affect the folding thermodynamics and kinetics of maltose binding protein. Febs Letters. 454: 307-11. PMID 10431828 DOI: 10.1016/S0014-5793(99)00826-1 |
0.424 |
|
| 1999 |
Chakravarty S, Varadarajan R. Residue depth: a novel parameter for the analysis of protein structure and stability Structure. 7: 723-732. PMID 10425675 DOI: 10.1016/S0969-2126(99)80097-5 |
0.447 |
|
| 1999 |
Ratnaparkhi GS, Varadarajan R. X-ray crystallographic studies of the denaturation of ribonuclease S. Proteins. 36: 282-294. PMID 10409822 DOI: 10.1002/(Sici)1097-0134(19990815)36:3<282::Aid-Prot3>3.0.Co;2-F |
0.323 |
|
| 1999 |
Chakshusmathi G, Ratnaparkhi GS, Madhu PK, Varadarajan R. Native-state hydrogen-exchange studies of a fragment complex can provide structural information about the isolated fragments. Proceedings of the National Academy of Sciences of the United States of America. 96: 7899-904. PMID 10393919 DOI: 10.1073/Pnas.96.14.7899 |
0.391 |
|
| 1999 |
GHOSHAL AK, SWAMINATHAN CP, THOMAS CJ, SUROLIA A, VARADARAJAN R. Thermodynamic and kinetic analysis of the Escherichia coli thioredoxin-C′ fragment complementation system Biochemical Journal. 339: 721-727. DOI: 10.1042/Bj3390721 |
0.399 |
|
| 1999 |
Manoj N, Srinivas VR, Surolia A, Vijayan M, Suguna K, Ravishankar R, Schwarzenbacher R, Zeth K, Diederichs, Kostner GM, Gries A, Laggner P, Prassl R, Madhusudan, Akamine P, ... ... Varadarajan R, ... ... Varadarajan R, et al. Contributory presentations/posters Journal of Biosciences. 24: 33-198. DOI: 10.1007/Bf02989373 |
0.505 |
|
| 1998 |
Panse VG, Udgaonkar JB, Varadarajan R. SecB binds only to a late native-like intermediate in the folding pathway of barstar and not to the unfolded state. Biochemistry. 37: 14477-83. PMID 9772175 DOI: 10.1021/Bi980777T |
0.444 |
|
| 1998 |
Ratnaparkhi GS, Ramachandran S, Udgaonkar JB, Varadarajan R. Discrepancies between the NMR and X-ray structures of uncomplexed barstar: analysis suggests that packing densities of protein structures determined by NMR are unreliable. Biochemistry. 37: 6958-66. PMID 9578582 DOI: 10.1021/Bi972857N |
0.354 |
|
| 1997 |
Ganesh C, Shah AN, Swaminathan CP, Surolia A, Varadarajan R. Thermodynamic characterization of the reversible, two-state unfolding of maltose binding protein, a large two-domain protein. Biochemistry. 36: 5020-8. PMID 9125524 DOI: 10.1021/Bi961967B |
0.425 |
|
| 1996 |
Varadarajan R, Nagarajaram HA, Ramakrishnan C. A procedure for the prediction of temperature-sensitive mutants of a globular protein based solely on the amino acid sequence Proceedings of the National Academy of Sciences of the United States of America. 93: 13908-13913. PMID 8943034 DOI: 10.1073/Pnas.93.24.13908 |
0.438 |
|
| 1996 |
Nadig G, Ratnaparkhi GS, Varadarajan R, Vishveshwara S. Dynamics of ribonuclease A and ribonuclease S: Computational and experimental studies Protein Science. 5: 2104-2114. PMID 8897611 DOI: 10.1002/Pro.5560051017 |
0.328 |
|
| 1994 |
Thomson J, Ratnaparkhi GS, Varadarajan R, Sturtevant JM, Richards FM. Thermodynamic and structural consequences of changing a sulfur atom to a methylene group in the M13Nle mutation in ribonuclease-S. Biochemistry. 33: 8587-93. PMID 8031793 DOI: 10.1021/Bi00194A025 |
0.614 |
|
| 1992 |
Varadarajan R, Connelly PR, Sturtevant JM, Richards FM. Heat capacity changes for protein-peptide interactions in the ribonuclease S system. Biochemistry. 31: 1421-6. PMID 1736999 DOI: 10.1021/Bi00120A019 |
0.626 |
|
| 1992 |
Varadarajan R, Richards FM. Crystallographic structures of ribonuclease S variants with nonpolar substitution at position 13: packing and cavities. Biochemistry. 31: 12315-27. PMID 1463720 DOI: 10.1021/Bi00164A005 |
0.59 |
|
| 1992 |
Kim EE, Varadarajan R, Wyckoff HW, Richards FM. Refinement of the crystal structure of ribonuclease S. Comparison with and between the various ribonuclease A structures. Biochemistry. 31: 12304-14. PMID 1463719 DOI: 10.1021/Bi00164A004 |
0.584 |
|
| 1990 |
Connelly PR, Varadarajan R, Sturtevant JM, Richards FM. Thermodynamics of protein-peptide interactions in the ribonuclease S system studied by titration calorimetry. Biochemistry. 29: 6108-14. PMID 2383573 DOI: 10.1021/Bi00477A031 |
0.615 |
|
| 1989 |
Varadarajan R, Lambright DG, Boxer SG. Electrostatic interactions in wild-type and mutant recombinant human myoglobins. Biochemistry. 28: 3771-81. PMID 2751994 DOI: 10.1021/Bi00435A022 |
0.609 |
|
| 1989 |
Varadarajan R, Zewert TE, Gray HB, Boxer SG. Effects of buried ionizable amino acids on the reduction potential of recombinant myoglobin. Science (New York, N.Y.). 243: 69-72. PMID 2563171 DOI: 10.1126/Science.2563171 |
0.562 |
|
| 1985 |
Varadarajan R, Szabo A, Boxer SG. Cloning, expression in Escherichia coli, and reconstitution of human myoglobin. Proceedings of the National Academy of Sciences of the United States of America. 82: 5681-4. PMID 3898068 DOI: 10.1073/Pnas.82.17.5681 |
0.511 |
|
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