Penny Clarke - Publications

Affiliations: 
University of Colorado Anschutz Medical Campus, Denver, Aurora, CO 

48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Clarke P, Leser JS, Tyler KL. Intrinsic innate immune responses control viral growth and protect against neuronal death in an model of WNV-induced CNS disease. Journal of Virology. JVI0083521. PMID 34190599 DOI: 10.1128/JVI.00835-21  1
2021 Dionne KR, Tyler KL, Clarke P. Slice Culture Modeling of CNS Viral Infection. Methods in Molecular Biology (Clifton, N.J.). 2311: 109-130. PMID 34033080 DOI: 10.1007/978-1-0716-1437-2_8  1
2021 Höschle C, Cubaynes HC, Clarke PJ, Humphries G, Borowicz A. The Potential of Satellite Imagery for Surveying Whales. Sensors (Basel, Switzerland). 21. PMID 33535463 DOI: 10.3390/s21030963  0.01
2020 Stonedahl S, Clarke P, Tyler KL. The Role of Microglia during West Nile Virus Infection of the Central Nervous System. Vaccines. 8. PMID 32872152 DOI: 10.3390/Vaccines8030485  1
2020 Potter H, Boyd TD, Clarke P, Pelak VS, Tyler KL. Recruiting the innate immune system with GM-CSF to fight viral diseases, including West Nile Virus encephalitis and COVID-19. F1000research. 9: 345. PMID 32704352 DOI: 10.12688/F1000Research.23729.1  1
2019 Hixon AM, Frost J, Rudy MJ, Messacar K, Clarke P, Tyler KL. Understanding Enterovirus D68-Induced Neurologic Disease: A Basic Science Review. Viruses. 11. PMID 31487952 DOI: 10.3390/V11090821  1
2019 Bonney S, Seitz S, Ryan CA, Jones KL, Clarke P, Tyler KL, Siegenthaler JA. Gamma Interferon Alters Junctional Integrity via Rho Kinase, Resulting in Blood-Brain Barrier Leakage in Experimental Viral Encephalitis. Mbio. 10. PMID 31387911 DOI: 10.1128/Mbio.01675-19  1
2019 Hixon AM, Clarke P, Tyler KL. Contemporary circulating enterovirus D68 strains infect and undergo retrograde axonal transport in spinal motor neurons independent of sialic acid. Journal of Virology. PMID 31167912 DOI: 10.1128/Jvi.00578-19  1
2019 Clarke P, Zhuang Y, Berens HM, Leser JS, Tyler KL. Interferon-β contributes to astrocyte activation in the brain following reovirus infection. Journal of Virology. PMID 30814290 DOI: 10.1128/Jvi.02027-18  1
2018 Seitz S, Clarke P, Tyler KL. Pharmacologic depletion of microglia increases viral load in the brain and enhances mortality in murine models of Flavivirus-induced encephalitis. Journal of Virology. PMID 29899084 DOI: 10.1128/Jvi.00525-18  1
2017 Hixon AM, Clarke P, Tyler KL. Evaluating treatment efficacy in a mouse model of enterovirus D68 paralytic myelitis. The Journal of Infectious Diseases. PMID 28968718 DOI: 10.1093/Infdis/Jix468  1
2017 Quick ED, Seitz S, Clarke P, Tyler KL. Minocycline has anti-inflammatory effects and reduces cytotoxicity in an ex vivo spinal cord slice culture model of West Nile virus infection. Journal of Virology. PMID 28878079 DOI: 10.1128/Jvi.00569-17  1
2017 Hixon AM, Yu G, Leser JS, Yagi S, Clarke P, Chiu CY, Tyler KL. A mouse model of paralytic myelitis caused by enterovirus D68. Plos Pathogens. 13: e1006199. PMID 28231269 DOI: 10.1371/Journal.Ppat.1006199  1
2016 Zhuang Y, Berens-Norman HM, Leser JS, Clarke P, Tyler KL. Mitochondrial p53 contributes to reovirus-induced neuronal apoptosis and CNS injury in a mouse model of viral encephalitis. Journal of Virology. PMID 27307572 DOI: 10.1128/Jvi.00583-16  1
2014 Quick ED, Leser JS, Clarke P, Tyler KL. Activation of intrinsic immune responses and microglial phagocytosis in an ex vivo spinal cord slice culture model of West Nile virus infection. Journal of Virology. 88: 13005-14. PMID 25165111 DOI: 10.1128/Jvi.01994-14  1
2014 Clarke P, Leser JS, Bowen RA, Tyler KL. Virus-induced transcriptional changes in the brain include the differential expression of genes associated with interferon, apoptosis, interleukin 17 receptor A, and glutamate signaling as well as flavivirus-specific upregulation of tRNA synthetases. Mbio. 5: e00902-14. PMID 24618253 DOI: 10.1128/Mbio.00902-14  1
2014 Clarke P, Leser JS, Quick ED, Dionne KR, Beckham JD, Tyler KL. Death receptor-mediated apoptotic signaling is activated in the brain following infection with West Nile virus in the absence of a peripheral immune response. Journal of Virology. 88: 1080-9. PMID 24198425 DOI: 10.1128/Jvi.02944-13  1
2013 Dionne KR, Zhuang Y, Leser JS, Tyler KL, Clarke P. Daxx upregulation within the cytoplasm of reovirus-infected cells is mediated by interferon and contributes to apoptosis. Journal of Virology. 87: 3447-60. PMID 23302889 DOI: 10.1128/Jvi.02324-12  1
2012 Schittone SA, Dionne KR, Tyler KL, Clarke P. Activation of innate immune responses in the central nervous system during reovirus myelitis. Journal of Virology. 86: 8107-18. PMID 22623770 DOI: 10.1128/Jvi.00171-12  1
2011 Dionne KR, Galvin JM, Schittone SA, Clarke P, Tyler KL. Type I interferon signaling limits reoviral tropism within the brain and prevents lethal systemic infection. Journal of Neurovirology. 17: 314-26. PMID 21671121 DOI: 10.1007/S13365-011-0038-1  1
2010 DeBiasi RL, Robinson BA, Leser JS, Brown RD, Long CS, Clarke P. Critical role for death-receptor mediated apoptotic signaling in viral myocarditis. Journal of Cardiac Failure. 16: 901-10. PMID 21055654 DOI: 10.1016/J.Cardfail.2010.05.030  1
2010 Tyler KL, Leser JS, Phang TL, Clarke P. Gene expression in the brain during reovirus encephalitis. Journal of Neurovirology. 16: 56-71. PMID 20158406 DOI: 10.3109/13550280903586394  1
2009 Clarke P, Beckham JD, Leser JS, Hoyt CC, Tyler KL. Fas-mediated apoptotic signaling in the mouse brain following reovirus infection. Journal of Virology. 83: 6161-70. PMID 19321603 DOI: 10.1128/Jvi.02488-08  1
2009 Clarke P, Tyler KL. Apoptosis in animal models of virus-induced disease. Nature Reviews. Microbiology. 7: 144-55. PMID 19148180 DOI: 10.1038/Nrmicro2071  1
2007 Beckham JD, Goody RJ, Clarke P, Bonny C, Tyler KL. Novel strategy for treatment of viral central nervous system infection by using a cell-permeating inhibitor of c-Jun N-terminal kinase. Journal of Virology. 81: 6984-92. PMID 17475657 DOI: 10.1128/Jvi.00467-07  1
2007 Clarke P, Tyler KL. Down-regulation of cFLIP following reovirus infection sensitizes human ovarian cancer cells to TRAIL-induced apoptosis. Apoptosis : An International Journal On Programmed Cell Death. 12: 211-23. PMID 17136319 DOI: 10.1007/S10495-006-0528-4  1
2005 Clarke P, Coleman MA, Holt RI. Alternative site self blood glucose testing is preferred by women with gestational diabetes. Diabetes Technology & Therapeutics. 7: 604-8. PMID 16120033 DOI: 10.1089/dia.2005.7.604  0.01
2005 Clarke P, Debiasi RL, Meintzer SM, Robinson BA, Tyler KL. Inhibition of NF-kappa B activity and cFLIP expression contribute to viral-induced apoptosis. Apoptosis : An International Journal On Programmed Cell Death. 10: 513-24. PMID 15909114 DOI: 10.1007/S10495-005-1881-4  1
2005 Clarke P, Debiasi RL, Goody R, Hoyt CC, Richardson-Burns S, Tyler KL. Mechanisms of reovirus-induced cell death and tissue injury: role of apoptosis and virus-induced perturbation of host-cell signaling and transcription factor activation. Viral Immunology. 18: 89-115. PMID 15802955 DOI: 10.1089/Vim.2005.18.89  1
2005 Clarke P, Richardson-Burns SM, DeBiasi RL, Tyler KL. Mechanisms of apoptosis during reovirus infection. Current Topics in Microbiology and Immunology. 289: 1-24. PMID 15791949 DOI: 10.1007/3-540-27320-4_1  1
2004 Clarke P, Meintzer SM, Wang Y, Moffitt LA, Richardson-Burns SM, Johnson GL, Tyler KL. JNK regulates the release of proapoptotic mitochondrial factors in reovirus-infected cells. Journal of Virology. 78: 13132-8. PMID 15542665 DOI: 10.1128/Jvi.78.23.13132-13138.2004  1
2004 Clarke PE, Gross H. Women's behaviour, beliefs and information sources about physical exercise in pregnancy. Midwifery. 20: 133-41. PMID 15177856 DOI: 10.1016/j.midw.2003.11.003  0.01
2003 DeBiasi RL, Clarke P, Meintzer S, Jotte R, Kleinschmidt-Demasters BK, Johnson GL, Tyler KL. Reovirus-induced alteration in expression of apoptosis and DNA repair genes with potential roles in viral pathogenesis. Journal of Virology. 77: 8934-47. PMID 12885910 DOI: 10.1128/Jvi.77.16.8934-8947.2003  1
2003 Clarke P, Tyler KL. Reovirus-induced apoptosis: A minireview Apoptosis. 8: 141-150. PMID 12766474 DOI: 10.1023/A:1022966508671  1
2003 Clarke P, Meintzer SM, Moffitt LA, Tyler KL. Two distinct phases of virus-induced nuclear factor kappa B regulation enhance tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in virus-infected cells. The Journal of Biological Chemistry. 278: 18092-100. PMID 12637521 DOI: 10.1074/Jbc.M300265200  1
2002 Spalding AC, Jotte RM, Scheinman RI, Geraci MW, Clarke P, Tyler KL, Johnson GL. TRAIL and inhibitors of apoptosis are opposing determinants for NF-kappaB-dependent, genotoxin-induced apoptosis of cancer cells. Oncogene. 21: 260-71. PMID 11803469 DOI: 10.1038/Sj.Onc.1205048  1
2001 Tyler KL, Clarke P, DeBiasi RL, Kominsky D, Poggioli GJ. Reoviruses and the host cell. Trends in Microbiology. 9: 560-4. PMID 11825717 DOI: 10.1016/S0966-842X(01)02103-5  1
2001 Clarke P, Meintzer SM, Widmann C, Johnson GL, Tyler KL. Reovirus infection activates JNK and the JNK-dependent transcription factor c-Jun Journal of Virology. 75: 11275-11283. PMID 11689607 DOI: 10.1128/Jvi.75.23.11275-11283.2001  1
2001 Clarke P, Meintzer SM, Spalding AC, Johnson GL, Tyler KL. Caspase 8-dependent sensitization of cancer cells to TRAIL-induced apoptosis following reovirus-infection. Oncogene. 20: 6910-9. PMID 11687970 DOI: 10.1038/Sj.Onc.1204842  1
2000 Clarke P, Meintzer SM, Gibson S, Widmann C, Garrington TP, Johnson GL, Tyler KL. Reovirus-induced apoptosis is mediated by TRAIL Journal of Virology. 74: 8135-8139. PMID 10933724 DOI: 10.1128/Jvi.74.17.8135-8139.2000  1
2000 Yujiri T, Ware M, Widmann C, Oyer R, Russell D, Chan E, Zaitsu Y, Clarke P, Tyler K, Oka Y, Fanger GR, Henson P, Johnson GL. MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activation Proceedings of the National Academy of Sciences of the United States of America. 97: 7272-7277. PMID 10852963 DOI: 10.1073/Pnas.130176697  1
2000 Connolly JL, Rodgers SE, Clarke P, Ballard DW, Kerr LD, Tyler KL, Dermody TS. Reovirus-induced apoptosis requires activation of transcription factor NF-kappaB. Journal of Virology. 74: 2981-9. PMID 10708412 DOI: 10.1128/Jvi.74.7.2981-2989.2000  1
1996 Clarke P, Matlock WL, Beer T, Gilden DH. A simian varicella virus (SVV) homolog to varicella-zoster virus gene 21 is expressed in monkey ganglia latently infected with SVV Journal of Virology. 70: 5711-5715. PMID 8764094 DOI: 10.1128/Jvi.70.8.5711-5715.1996  1
1995 Clarke P, Beer T, Gilden DH. Configuration and terminal sequences of the simian varicella virus genome Virology. 207: 154-159. PMID 7871724 DOI: 10.1006/Viro.1995.1061  1
1995 Clarke P, Beer T, Cohrs R, Gilden DH. Configuration of latent Varicella-Zoster virus DNA Journal of Virology. 69: 8151-8154. PMID 7494340 DOI: 10.1128/Jvi.69.12.8151-8154.1995  1
1993 Clarke P, Brunschwig A, Gilden DH. DNA sequence of a simian varicella virus gene that encodes a homologue of varicella zoster virus IE62 and herpes simplex virus ICP4 Virology. 197: 45-52. PMID 8212583 DOI: 10.1006/Viro.1993.1565  1
1992 Clarke P, Rabkin SD, Inman MV, Mahalingam R, Cohrs R, Wellish M, Gilden DH. Molecular analysis of simian varicella virus DNA. Virology. 190: 597-605. PMID 1519354 DOI: 10.1016/0042-6822(92)90897-X  1
1992 Mahalingam R, Clarke P, Wellish M, Dueland AN, Soike KF, Gilden DH, Cohrs R. Prevalence and distribution of latent simian varicella virus DNA in monkey ganglia Virology. 188: 193-197. PMID 1314451 DOI: 10.1016/0042-6822(92)90749-F  1
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