| Year |
Citation |
Score |
| 2024 |
Ahmed AA, Chen S, Roman-Escorza M, Angell R, Oxenford S, McConville M, Barton N, Sunose M, Neidle D, Haider S, Arshad T, Neidle S. Structure-activity relationships for the G-quadruplex-targeting experimental drug QN-302 and two analogues probed with comparative transcriptome profiling and molecular modeling. Scientific Reports. 14: 3447. PMID 38342953 DOI: 10.1038/s41598-024-54080-2 |
0.357 |
|
| 2023 |
Alexandrou E, Guneri D, Neidle S, Waller ZAE. QN-302 demonstrates opposing effects between i-motif and G-quadruplex DNA structures in the promoter of the S100P gene. Organic & Biomolecular Chemistry. PMID 37970888 DOI: 10.1039/d3ob01464a |
0.373 |
|
| 2022 |
Satange R, Kao SH, Chien CM, Chou SH, Lin CC, Neidle S, Hou MH. Staggered intercalation of DNA duplexes with base-pair modulation by two distinct drug molecules induces asymmetric backbone twisting and structure polymorphism. Nucleic Acids Research. 50: 8867-8881. PMID 35871296 DOI: 10.1093/nar/gkac629 |
0.358 |
|
| 2021 |
Neidle S. Structured Waters Mediate Small Molecule Binding to G-Quadruplex Nucleic Acids. Pharmaceuticals (Basel, Switzerland). 15. PMID 35056064 DOI: 10.3390/ph15010007 |
0.364 |
|
| 2021 |
Jhan CR, Satange R, Wang SC, Zeng JY, Horng YC, Jin P, Neidle S, Hou MH. Targeting the ALS/FTD-associated A-DNA kink with anthracene-based metal complex causes DNA backbone straightening and groove contraction. Nucleic Acids Research. PMID 33836081 DOI: 10.1093/nar/gkab227 |
0.343 |
|
| 2021 |
Neidle S. Beyond the double helix: DNA structural diversity and the PDB. The Journal of Biological Chemistry. 100553. PMID 33744292 DOI: 10.1016/j.jbc.2021.100553 |
0.326 |
|
| 2020 |
Ahmed AA, Neidle S. A G-Quadruplex-Binding Small Molecule and the HDAC Inhibitor SAHA (Vorinostat) Act Synergistically in Gemcitabine-Sensitive and Resistant Pancreatic Cancer Cells. Molecules (Basel, Switzerland). 25. PMID 33227941 DOI: 10.3390/molecules25225407 |
0.331 |
|
| 2020 |
Ahmed AA, Angell R, Oxenford S, Worthington J, Williams N, Barton N, Fowler TG, O'Flynn DE, Sunose M, McConville M, Vo T, Wilson WD, Karim SA, Morton JP, Neidle S. Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models. Acs Medicinal Chemistry Letters. 11: 1634-1644. PMID 32832034 DOI: 10.1021/Acsmedchemlett.0C00317 |
0.378 |
|
| 2020 |
Ahmed AA, Marchetti C, Ohnmacht SA, Neidle S. A G-quadruplex-binding compound shows potent activity in human gemcitabine-resistant pancreatic cancer cells. Scientific Reports. 10: 12192. PMID 32699225 DOI: 10.1038/S41598-020-68944-W |
0.746 |
|
| 2020 |
Vo T, Oxenford S, Angell R, Marchetti C, Ohnmacht SA, Wilson WD, Neidle S. Substituted Naphthalenediimide Compounds Bind Selectively to Two Human Quadruplex Structures with Parallel Topology. Acs Medicinal Chemistry Letters. 11: 991-999. PMID 32435416 DOI: 10.1021/Acsmedchemlett.0C00041 |
0.79 |
|
| 2019 |
Satange R, Chuang CY, Neidle S, Hou MH. Polymorphic G:G mismatches act as hotspots for inducing right-handed Z DNA by DNA intercalation. Nucleic Acids Research. PMID 31361900 DOI: 10.1093/Nar/Gkz653 |
0.465 |
|
| 2019 |
Mendes E, Cadoni E, Carneiro F, Afonso MB, Brito H, Lavrado J, Dos Santos DJVA, Vítor JB, Neidle S, Rodrigues CMP, Paulo A. Combining 1,3-ditriazolyl-benzene and quinoline to discover a new G-quadruplex interactive small molecule active against cancer stem-like cells. Chemmedchem. PMID 31162877 DOI: 10.1002/Cmdc.201900243 |
0.463 |
|
| 2019 |
Mizuta R, Devos JM, Narayanan T, Oliva M, Gray M, Webster J, Ling W, Round A, Munnur D, Mossou E, Farahat A, Boykin DW, Wilson WD, Neidle S, Schweins R, et al. Hierarchical Nanotube Self‐Assembly of DNA Minor Groove‐Binding Ligand DB921 via Alkali Halide Triggering Macromolecular Symposia. 386: 1800243. DOI: 10.1002/Masy.201800243 |
0.359 |
|
| 2018 |
Gunaratnam M, Collie GW, Reszka AP, Todd AK, Parkinson GN, Neidle S. A naphthalene diimide G-quadruplex ligand inhibits cell growth and down-regulates BCL-2 expression in an imatinib-resistant gastrointestinal cancer cell line. Bioorganic & Medicinal Chemistry. PMID 29724653 DOI: 10.1016/J.Bmc.2018.04.050 |
0.788 |
|
| 2018 |
Mizuta R, Devos JM, Webster J, Ling WL, Narayanan T, Round A, Munnur D, Mossou E, Farahat AA, Boykin DW, Wilson WD, Neidle S, Schweins R, Rannou P, Haertlein M, et al. Dynamic self-assembly of DNA minor groove-binding ligand DB921 into nanotubes triggered by an alkali halide. Nanoscale. PMID 29517086 DOI: 10.1039/C7Nr03875E |
0.334 |
|
| 2018 |
Marchetti C, Zyner KG, Ohnmacht SA, Robson M, Haider SM, Morton JP, Marsico G, Vo T, Laughlin-Toth S, Ahmed AA, Di Vita G, Pazitna I, Gunaratnam M, Besser RJ, Andrade AC, ... ... Neidle S, et al. Targeting multiple effector pathways in pancreatic ductal adenocarcinoma with a G-quadruplex-binding small molecule. Journal of Medicinal Chemistry. PMID 29356532 DOI: 10.1021/Acs.Jmedchem.7B01781 |
0.816 |
|
| 2017 |
Simone R, Balendra R, Moens TG, Preza E, Wilson KM, Heslegrave A, Woodling NS, Niccoli T, Gilbert-Jaramillo J, Abdelkarim S, Clayton EL, Clarke M, Konrad MT, Nicoll AJ, Mitchell JS, ... ... Neidle S, et al. G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo. Embo Molecular Medicine. PMID 29113975 DOI: 10.15252/Emmm.201707850 |
0.676 |
|
| 2017 |
Tseng WH, Chang CK, Wu PC, Hu NJ, Lee GH, Tzeng CC, Neidle S, Hou MH. Induced-fit recognition of CCG trinucleotide repeats by a nickel chromomycin complex results in large-scale DNA deformation. Angewandte Chemie (International Ed. in English). PMID 28544401 DOI: 10.1002/Anie.201703989 |
0.431 |
|
| 2017 |
Islam B, Stadlbauer P, Gil Ley A, Pérez-Hernández G, Haider S, Neidle S, Bussi G, Banáš P, Otyepka M, Sponer J. Exploring the Dynamics of Propeller Loops in Human Telomeric DNA Quadruplexes Using Atomistic Simulations. Journal of Chemical Theory and Computation. PMID 28475322 DOI: 10.1021/Acs.Jctc.7B00226 |
0.336 |
|
| 2016 |
Šponer J, Bussi G, Stadlbauer P, Kührová P, Banáš P, Islam B, Haider S, Neidle S, Otyepka M. Folding of guanine quadruplex molecules-funnel-like mechanism or kinetic partitioning? An overview from MD simulation studies. Biochimica Et Biophysica Acta. PMID 27979677 DOI: 10.1016/J.Bbagen.2016.12.008 |
0.333 |
|
| 2016 |
Amato J, Morigi R, Pagano B, Pagano A, Ohnmacht SA, De Magis A, Tiang YP, Capranico G, Locatelli A, Graziadio A, Leoni A, Rambaldi M, Novellino E, Neidle S, Randazzo A. Toward the development of specific G-quadruplex binders: synthesis, biophysical and biological studies of new hydrazone derivatives. Journal of Medicinal Chemistry. PMID 27223049 DOI: 10.1021/Acs.Jmedchem.6B00129 |
0.793 |
|
| 2016 |
Islam B, Stadlbauer P, Neidle S, Haider S, Sponer J. Can We Execute Reliable MM-PBSA Free Energy Computations of Relative Stabilities of Different Guanine Quadruplex Folds? The Journal of Physical Chemistry. B. PMID 26918369 DOI: 10.1021/Acs.Jpcb.6B01059 |
0.337 |
|
| 2016 |
Neidle S. Quadruplex Nucleic Acids as Novel Therapeutic Targets. Journal of Medicinal Chemistry. PMID 26840940 DOI: 10.1021/Acs.Jmedchem.5B01835 |
0.428 |
|
| 2016 |
Russo Krauss I, Ramaswamy S, Neidle S, Haider S, Parkinson GN. Structural Insights into the Quadruplex-Duplex 3' Interface formed from a Telomeric Repeat: A Potential Molecular Target. Journal of the American Chemical Society. PMID 26730610 DOI: 10.1021/Jacs.5B10492 |
0.751 |
|
| 2016 |
Balendra R, Mizielinska S, Moens T, Niccoli T, Ridler C, Simone R, Woodling N, Parkinson G, Neidle S, Patani R, Partridge L, Isaacs A. Molecular mechanisms and therapeutic strategies in amyotrophic lateral sclerosis caused by C9orf72 mutations The Lancet. 387. DOI: 10.1016/S0140-6736(16)00400-1 |
0.629 |
|
| 2015 |
Mann J, Taylor PW, Dorgan CR, Johnson PD, Wilson FX, Vickers R, Dale AG, Neidle S. The discovery of a novel antibiotic for the treatment of Clostridium difficile infections: a story of an effective academic-industrial partnership. Medchemcomm. 6: 1420-1426. PMID 26949507 DOI: 10.1039/C5Md00238A |
0.727 |
|
| 2015 |
Islam B, Stadlbauer P, Krepl M, Koca J, Neidle S, Haider S, Sponer J. Extended molecular dynamics of a c-kit promoter quadruplex. Nucleic Acids Research. 43: 8673-93. PMID 26245347 DOI: 10.1093/Nar/Gkv785 |
0.385 |
|
| 2015 |
Roe S, Gunaratnam M, Spiteri C, Sharma P, Alharthy RD, Neidle S, Moses JE. Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors. Organic & Biomolecular Chemistry. PMID 26156660 DOI: 10.1039/C5Ob01177A |
0.679 |
|
| 2015 |
Neidle S. A Personal History of Quadruplex-Small Molecule Targeting. Chemical Record (New York, N.Y.). 15: 691-710. PMID 26096791 DOI: 10.1002/Tcr.201500011 |
0.403 |
|
| 2015 |
Ohnmacht SA, Marchetti C, Gunaratnam M, Besser RJ, Haider SM, Di Vita G, Lowe HL, Mellinas-Gomez M, Diocou S, Robson M, Šponer J, Islam B, Pedley RB, Hartley JA, Neidle S. A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer. Scientific Reports. 5: 11385. PMID 26077929 DOI: 10.1038/Srep11385 |
0.813 |
|
| 2015 |
Brito H, Martins AC, Lavrado J, Mendes E, Francisco AP, Santos SA, Ohnmacht SA, Kim NS, Rodrigues CM, Moreira R, Neidle S, Borralho PM, Paulo A. Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives. Plos One. 10: e0126891. PMID 26024321 DOI: 10.1371/Journal.Pone.0126891 |
0.776 |
|
| 2015 |
Simone R, Fratta P, Neidle S, Parkinson GN, Isaacs AM. G-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptome. Febs Letters. 589: 1653-68. PMID 25979174 DOI: 10.1016/J.Febslet.2015.05.003 |
0.694 |
|
| 2015 |
Chiorcea-Paquim AM, Pontinha AD, Eritja R, Lucarelli G, Sparapani S, Neidle S, Oliveira-Brett AM. Atomic Force Microscopy and Voltammetric Investigation of Quadruplex Formation between a Triazole-Acridine Conjugate and Guanine-Containing Repeat DNA Sequences. Analytical Chemistry. 87: 6141-9. PMID 25961908 DOI: 10.1021/Acs.Analchem.5B00743 |
0.807 |
|
| 2015 |
Collie GW, Campbell NH, Neidle S. Loop flexibility in human telomeric quadruplex small-molecule complexes. Nucleic Acids Research. 43: 4785-99. PMID 25940631 DOI: 10.1093/Nar/Gkv427 |
0.422 |
|
| 2015 |
Marchetti C, Minarini A, Tumiatti V, Moraca F, Parrotta L, Alcaro S, Rigo R, Sissi C, Gunaratnam M, Ohnmacht SA, Neidle S, Milelli A. Macrocyclic naphthalene diimides as G-quadruplex binders. Bioorganic & Medicinal Chemistry. 23: 3819-30. PMID 25935290 DOI: 10.1016/J.Bmc.2015.03.076 |
0.837 |
|
| 2015 |
Lavrado J, Brito H, Borralho PM, Ohnmacht SA, Kim NS, Leitão C, Pisco S, Gunaratnam M, Rodrigues CM, Moreira R, Neidle S, Paulo A. KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines. Scientific Reports. 5: 9696. PMID 25853628 DOI: 10.1038/Srep09696 |
0.819 |
|
| 2015 |
Lavrado J, Ohnmacht SA, Correia I, Leitão C, Pisco S, Gunaratnam M, Moreira R, Neidle S, Santos DJ, Paulo A. Indolo[3,2-c]quinoline G-quadruplex stabilizers: a structural analysis of binding to the human telomeric G-quadruplex. Chemmedchem. 10: 836-49. PMID 25820698 DOI: 10.1002/Cmdc.201500067 |
0.824 |
|
| 2015 |
Wei D, Husby J, Neidle S. Flexibility and structural conservation in a c-KIT G-quadruplex. Nucleic Acids Research. 43: 629-44. PMID 25452341 DOI: 10.1093/Nar/Gku1282 |
0.799 |
|
| 2015 |
Pontinha AD, Lombardo CM, Neidle S, Oliveira-Brett AM. Triazole-linked phenyl derivatives: redox mechanisms and in situ electrochemical evaluation of interaction with dsDNA. Bioelectrochemistry (Amsterdam, Netherlands). 101: 97-105. PMID 25194950 DOI: 10.1016/J.Bioelechem.2014.08.010 |
0.624 |
|
| 2015 |
Wei D, Husby J, Neidle S. Flexibility and structural conservation in a c-KIT G-quadruplex Nucleic Acids Research. 43: 629-644. DOI: 10.1093/nar/gku1282 |
0.786 |
|
| 2015 |
Mann J, Taylor PW, Dorgan CR, Johnson PD, Wilson FX, Vickers R, Dale AG, Neidle S. The discovery of a novel antibiotic for the treatment of Clostridium difficile infections: A story of an effective academic-industrial partnership Medchemcomm. 6: 1420-1426. DOI: 10.1039/c5md00238a |
0.683 |
|
| 2015 |
Ohnmacht SA, Marchetti C, Gunaratnam M, Besser RJ, Haider SM, Di Vita G, Lowe HL, Mellinas-Gomez M, Diocou S, Robson M, Šponer J, Islam B, Barbara Pedley R, Hartley JA, Neidle S. A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer Scientific Reports. 5. DOI: 10.1038/srep11385 |
0.686 |
|
| 2015 |
Chiorcea-Paquim AM, Pontinha ADR, Eritja R, Lucarelli G, Sparapani S, Neidle S, Oliveira-Brett AM. Atomic Force Microscopy and Voltammetric Investigation of Quadruplex Formation between a Triazole-Acridine Conjugate and Guanine-Containing Repeat DNA Sequences Analytical Chemistry. 87: 6141-6149. DOI: 10.1021/acs.analchem.5b00743 |
0.772 |
|
| 2015 |
Marchetti C, Minarini A, Tumiatti V, Moraca F, Parrotta L, Alcaro S, Rigo R, Sissi C, Gunaratnam M, Ohnmacht SA, Neidle S, Milelli A. Macrocyclic naphthalene diimides as G-quadruplex binders Bioorganic and Medicinal Chemistry. 23: 3819-3830. DOI: 10.1016/j.bmc.2015.03.076 |
0.666 |
|
| 2015 |
Pontinha ADR, Lombardo CM, Neidle S, Oliveira-Brett AM. Triazole-linked phenyl derivatives: Redox mechanisms and in situ electrochemical evaluation of interaction with dsDNA Bioelectrochemistry. 101: 97-105. DOI: 10.1016/j.bioelechem.2014.08.010 |
0.554 |
|
| 2015 |
Lavrado J, Ohnmacht SA, Correia I, Leitão C, Pisco S, Gunaratnam M, Moreira R, Neidle S, Santos DJVAD, Paulo A. Indolo[3,2-c]quinoline G-quadruplex stabilizers: A structural analysis of binding to the human telomeric G-quadruplex Chemmedchem. 10: 836-849. DOI: 10.1002/cmdc.201500067 |
0.819 |
|
| 2014 |
Chen YW, Jhan CR, Neidle S, Hou MH. Structural basis for the identification of an i-motif tetraplex core with a parallel-duplex junction as a structural motif in CCG triplet repeats. Angewandte Chemie (International Ed. in English). 53: 10682-6. PMID 25139267 DOI: 10.1002/Anie.201405637 |
0.405 |
|
| 2014 |
Ohnmacht SA, Neidle S. Small-molecule quadruplex-targeted drug discovery. Bioorganic & Medicinal Chemistry Letters. 24: 2602-12. PMID 24814531 DOI: 10.1016/J.Bmcl.2014.04.029 |
0.761 |
|
| 2014 |
Nasiri HR, Bell NM, McLuckie KI, Husby J, Abell C, Neidle S, Balasubramanian S. Targeting a c-MYC G-quadruplex DNA with a fragment library. Chemical Communications (Cambridge, England). 50: 1704-7. PMID 24394582 DOI: 10.1039/C3Cc48390H |
0.803 |
|
| 2014 |
Chai Y, Munde M, Kumar A, Mickelson L, Lin S, Campbell NH, Banerjee M, Akay S, Liu Z, Farahat AA, Nhili R, Depauw S, David-Cordonnier MH, Neidle S, Wilson WD, et al. Structure-dependent binding of arylimidamides to the DNA minor groove. Chembiochem : a European Journal of Chemical Biology. 15: 68-79. PMID 24323836 DOI: 10.1002/Cbic.201300622 |
0.463 |
|
| 2014 |
Ohnmacht SA, Varavipour E, Nanjunda R, Pazitna I, Di Vita G, Gunaratnam M, Kumar A, Ismail MA, Boykin DW, Wilson WD, Neidle S. Discovery of new G-quadruplex binding chemotypes. Chemical Communications (Cambridge, England). 50: 960-3. PMID 24302123 DOI: 10.1039/C3Cc48616H |
0.82 |
|
| 2013 |
Wei D, Todd AK, Zloh M, Gunaratnam M, Parkinson GN, Neidle S. Crystal structure of a promoter sequence in the B-raf gene reveals an intertwined dimer quadruplex Journal of the American Chemical Society. 135: 19319-19329. PMID 24295054 DOI: 10.1021/Ja4101358 |
0.802 |
|
| 2013 |
Altieri A, Alvino A, Ohnmacht S, Ortaggi G, Neidle S, Nocioni D, Franceschin M, Bianco A. Xanthene and xanthone derivatives as G-quadruplex stabilizing ligands Molecules. 18: 13446-13470. PMID 24177701 DOI: 10.3390/Molecules181113446 |
0.803 |
|
| 2013 |
Welsh SJ, Dale AG, Lombardo CM, Valentine H, de la Fuente M, Schatzlein A, Neidle S. Inhibition of the hypoxia-inducible factor pathway by a G-quadruplex binding small molecule. Scientific Reports. 3: 2799. PMID 24165797 DOI: 10.1038/Srep02799 |
0.796 |
|
| 2013 |
Shiu WK, Malkinson JP, Rahman MM, Curry J, Stapleton P, Gunaratnam M, Neidle S, Mushtaq S, Warner M, Livermore DM, Evangelopoulos D, Basavannacharya C, Bhakta S, Schindler BD, Seo SM, et al. A new plant-derived antibacterial is an inhibitor of efflux pumps in Staphylococcus aureus. International Journal of Antimicrobial Agents. 42: 513-8. PMID 24119569 DOI: 10.1016/J.Ijantimicag.2013.08.007 |
0.644 |
|
| 2013 |
Ohnmacht SA, Ciancimino C, Vignaroli G, Gunaratnam M, Neidle S. Optimization of anti-proliferative activity using a screening approach with a series of bis-heterocyclic G-quadruplex ligands Bioorganic and Medicinal Chemistry Letters. 23: 5351-5355. PMID 23972440 DOI: 10.1016/J.Bmcl.2013.07.057 |
0.825 |
|
| 2013 |
Lavrado J, Borralho PM, Ohnmacht SA, Castro RE, Rodrigues CM, Moreira R, dos Santos DJ, Neidle S, Paulo A. Synthesis, G-quadruplex stabilisation, docking studies, and effect on cancer cells of indolo[3,2-b]quinolines with one, two, or three basic side chains. Chemmedchem. 8: 1648-61. PMID 23960016 DOI: 10.1002/Cmdc.201300288 |
0.798 |
|
| 2013 |
Husby J, Todd AK, Platts JA, Neidle S. Small-molecule G-quadruplex interactions: Systematic exploration of conformational space using multiple molecular dynamics. Biopolymers. 99: 989-1005. PMID 23828641 DOI: 10.1002/Bip.22340 |
0.815 |
|
| 2013 |
Mpima S, Ohnmacht SA, Barletta M, Husby J, Pett LC, Gunaratnam M, Hilton ST, Neidle S. The influence of positional isomerism on G-quadruplex binding and anti-proliferative activity of tetra-substituted naphthalene diimide compounds. Bioorganic & Medicinal Chemistry. 21: 6162-70. PMID 23769166 DOI: 10.1016/J.Bmc.2013.05.027 |
0.806 |
|
| 2013 |
Micco M, Collie GW, Dale AG, Ohnmacht SA, Pazitna I, Gunaratnam M, Reszka AP, Neidle S. Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells. Journal of Medicinal Chemistry. 56: 2959-74. PMID 23514618 DOI: 10.1021/Jm301899Y |
0.832 |
|
| 2013 |
Nkansah E, Shah R, Collie GW, Parkinson GN, Palmer J, Rahman KM, Bui TT, Drake AF, Husby J, Neidle S, Zinzalla G, Thurston DE, Wilderspin AF. Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography Febs Letters. 587: 833-839. PMID 23434585 DOI: 10.1016/J.Febslet.2013.01.065 |
0.805 |
|
| 2013 |
Baud MG, Leiser T, Petrucci V, Gunaratnam M, Neidle S, Meyer-Almes FJ, Fuchter MJ. Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors. Beilstein Journal of Organic Chemistry. 9: 81-8. PMID 23400330 DOI: 10.3762/Bjoc.9.11 |
0.672 |
|
| 2013 |
Mitchell T, Ramos-Montoya A, Di Antonio M, Murat P, Ohnmacht S, Micco M, Jurmeister S, Fryer L, Balasubramanian S, Neidle S, Neal DE. Downregulation of androgen receptor transcription by promoter g-quadruplex stabilization as a potential alternative treatment for castrate-resistant prostate cancer. Biochemistry. 52: 1429-36. PMID 23363071 DOI: 10.1021/Bi301349C |
0.762 |
|
| 2013 |
Islam B, Sgobba M, Laughton C, Orozco M, Sponer J, Neidle S, Haider S. Conformational dynamics of the human propeller telomeric DNA quadruplex on a microsecond time scale Nucleic Acids Research. 41: 2723-2735. PMID 23293000 DOI: 10.1093/Nar/Gks1331 |
0.647 |
|
| 2013 |
Hampel SM, Pepe A, Greulich-Bode KM, Malhotra SV, Reszka AP, Veith S, Boukamp P, Neidle S. Mechanism of the antiproliferative activity of some naphthalene diimide G-quadruplex ligands Molecular Pharmacology. 83: 470-480. PMID 23188717 DOI: 10.1124/Mol.112.081075 |
0.454 |
|
| 2013 |
Pontinha ADR, Sparapani S, Neidle S, Oliveira-Brett AM. Triazole-acridine conjugates: Redox mechanisms and in situ electrochemical evaluation of interaction with double-stranded DNA Bioelectrochemistry. 89: 50-56. PMID 23059201 DOI: 10.1016/J.Bioelechem.2012.08.005 |
0.803 |
|
| 2013 |
Baud MGJ, Leiser T, Petrucci V, Gunaratnam M, Neidle S, Meyer-Almes FJ, Fuchter MJ. Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors Beilstein Journal of Organic Chemistry. 9: 81-88. DOI: 10.3762/bjoc.9.11 |
0.603 |
|
| 2013 |
Mitchell T, Ramos-Montoya A, Di Antonio M, Murat P, Ohnmacht S, Micco M, Fryer L, Balasubramanian S, Neidle S, Neal D. 823 Transcriptional down-regulation of the androgen receptor by promoter G-quadruplex stabilisation; a potential alternative treatment in castrate-resistant prostate cancer European Urology Supplements. 12: e823-e824. DOI: 10.1016/S1569-9056(13)61303-2 |
0.718 |
|
| 2013 |
Lavrado J, Borralho PM, Ohnmacht SA, Castro RE, Rodrigues CMP, Moreira R, Dos Santos DJVA, Neidle S, Paulo A. Synthesis, G-quadruplex stabilisation, docking studies, and effect on cancer cells of indolo[3,2-b]quinolines with one, two, or three basic side chains Chemmedchem. 8: 1648-1661. DOI: 10.1002/cmdc.201300288 |
0.73 |
|
| 2013 |
Husby J, Todd AK, Platts JA, Neidle S. Small-molecule G-quadruplex interactions: Systematic exploration of conformational space using multiple molecular dynamics Biopolymers. 99: 989-1005. DOI: 10.1002/bip.22340 |
0.771 |
|
| 2012 |
Campbell N, Collie GW, Neidle S. Crystallography of DNA and RNA G-Quadruplex nucleic acids and their ligand complexes Current Protocols in Nucleic Acid Chemistry. PMID 22956455 DOI: 10.1002/0471142700.Nc1706S50 |
0.417 |
|
| 2012 |
Ohnmacht SA, Micco M, Petrucci V, Todd AK, Reszka AP, Gunaratnam M, Carvalho MA, Zloh M, Neidle S. Sequences in the HSP90 promoter form G-quadruplex structures with selectivity for disubstituted phenyl bis-oxazole derivatives Bioorganic and Medicinal Chemistry Letters. 22: 5930-5935. PMID 22892119 DOI: 10.1016/J.Bmcl.2012.07.065 |
0.833 |
|
| 2012 |
Lombardo CM, Welsh SJ, Strauss SJ, Dale AG, Todd AK, Nanjunda R, Wilson WD, Neidle S. A novel series of G-quadruplex ligands with selectivity for HIF-expressing osteosarcoma and renal cancer cell lines. Bioorganic & Medicinal Chemistry Letters. 22: 5984-8. PMID 22889802 DOI: 10.1016/J.Bmcl.2012.07.009 |
0.81 |
|
| 2012 |
Rahman KM, Hossain MD, Sohrab MH, Drake AF, Bui TT, Husby J, Gunaratnam M, Neidle S, Hasan CM, Thurston DE. The prenylated dioxopiperazine alkaloid Cristatin A has selective telomeric DNA G-quadruplex stabilising properties Chemical Communications. 48: 8760-8762. PMID 22836516 DOI: 10.1039/C2Cc31277H |
0.824 |
|
| 2012 |
Neidle S. Interactions with DNA: Into the minor groove. Nature Chemistry. 4: 594-5. PMID 22824886 DOI: 10.1038/Nchem.1413 |
0.41 |
|
| 2012 |
Neidle S. Methods for studying quadruplexes: Sequence, structure, recognition and biological behaviour Methods. 57: 1-2. PMID 22819854 DOI: 10.1016/J.Ymeth.2012.05.014 |
0.321 |
|
| 2012 |
Dale AG, Hinds J, Mann J, Taylor PW, Neidle S. Symmetric bis-benzimidazoles are potent anti-staphylococcal agents with dual inhibitory mechanisms against DNA gyrase. Biochemistry. 51: 5860-71. PMID 22746203 DOI: 10.1021/Bi300645N |
0.784 |
|
| 2012 |
Husby J, Todd AK, Haider SM, Zinzalla G, Thurston DE, Neidle S. Molecular dynamics studies of the STAT3 homodimer:DNA complex: Relationships between STAT3 mutations and protein-DNA recognition Journal of Chemical Information and Modeling. 52: 1179-1192. PMID 22500887 DOI: 10.1021/Ci200625Q |
0.805 |
|
| 2012 |
Rahman KM, Tizkova K, Reszka AP, Neidle S, Thurston DE. Identification of novel telomeric G-quadruplex-targeting chemical scaffolds through screening of three NCI libraries Bioorganic and Medicinal Chemistry Letters. 22: 3006-3010. PMID 22421021 DOI: 10.1016/J.Bmcl.2012.02.020 |
0.465 |
|
| 2012 |
Howell LA, Bowater RA, O'Connell MA, Reszka AP, Neidle S, Searcey M. Synthesis of small molecules targeting multiple DNA structures using click chemistry. Chemmedchem. 7: 792-804. PMID 22378532 DOI: 10.1002/Cmdc.201200060 |
0.495 |
|
| 2012 |
Wangteeraprasert R, Lipipun V, Gunaratnam M, Neidle S, Gibbons S, Likhitwitayawuid K. Bioactive compounds from Carissa spinarum Phytotherapy Research. 26: 1496-1499. PMID 22308099 DOI: 10.1002/Ptr.4607 |
0.659 |
|
| 2012 |
Wei D, Parkinson GN, Reszka AP, Neidle S. Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation Nucleic Acids Research. 40: 4691-4700. PMID 22287624 DOI: 10.1093/Nar/Gks023 |
0.674 |
|
| 2012 |
Collie GW, Promontorio R, Hampel SM, Micco M, Neidle S, Parkinson GN. Structural basis for telomeric G-quadruplex targeting by naphthalene diimide ligands Journal of the American Chemical Society. 134: 2723-2731. PMID 22280460 DOI: 10.1021/Ja2102423 |
0.765 |
|
| 2012 |
Baud MGJ, Leiser T, Haus P, Samlal S, Wong AC, Wood RJ, Petrucci V, Gunaratnam M, Hughes SM, Buluwela L, Turlais F, Neidle S, Meyer-Almes FJ, White AJP, Fuchter MJ. Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets Journal of Medicinal Chemistry. 55: 1731-1750. PMID 22280363 DOI: 10.1021/Jm2016182 |
0.691 |
|
| 2012 |
Campbell NH, Neidle S. G-quadruplexes and metal ions. Metal Ions in Life Sciences. 10: 119-134. PMID 22210337 DOI: 10.1007/978-94-007-2172-2_4 |
0.369 |
|
| 2012 |
Campbell NH, Karim NHA, Parkinson GN, Gunaratnam M, Petrucci V, Todd AK, Vilar R, Neidle S. Molecular basis of structure-activity relationships between salphen metal complexes and human telomeric DNA quadruplexes Journal of Medicinal Chemistry. 55: 209-222. PMID 22112241 DOI: 10.1021/Jm201140V |
0.811 |
|
| 2012 |
Micco M, Collie G, Gunaratnam M, Ohnmacht SA, Reszka AP, Neidle S. Abstract LB-2: Structure-based design of G-quadruplex ligands leads to enhanced potency against pancreatic cancer cells Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-2 |
0.737 |
|
| 2011 |
Gunaratnam M, Fuente MDL, Hampel SM, Todd AK, Reszka AP, Schätzlein A, Neidle S. Targeting pancreatic cancer with a G-quadruplex ligand Bioorganic and Medicinal Chemistry. 19: 7151-7157. PMID 22041170 DOI: 10.1016/J.Bmc.2011.09.055 |
0.748 |
|
| 2011 |
Petraccone L, Fotticchia I, Cummaro A, Pagano B, Ginnari-Satriani L, Haider S, Randazzo A, Novellino E, Neidle S, Giancola C. The triazatruxene derivative azatrux binds to the parallel form of the human telomeric G-quadruplex under molecular crowding conditions: Biophysical and molecular modeling studies Biochimie. 93: 1318-1327. PMID 21641960 DOI: 10.1016/J.Biochi.2011.05.017 |
0.479 |
|
| 2011 |
Haider SM, Autiero I, Neidle S. Surface area accessibility and the preferred topology of telomeric DNA quadruplex-ligand complexes Biochimie. 93: 1275-1279. PMID 21641959 DOI: 10.1016/J.Biochi.2011.05.014 |
0.365 |
|
| 2011 |
Haider SM, Neidle S, Parkinson GN. A structural analysis of G-quadruplex/ligand interactions Biochimie. 93: 1239-1251. PMID 21635933 DOI: 10.1016/J.Biochi.2011.05.012 |
0.722 |
|
| 2011 |
Liu Y, Kumar A, Depauw S, Nhili R, David-Cordonnier MH, Lee MP, Ismail MA, Farahat AA, Say M, Chackal-Catoen S, Batista-Parra A, Neidle S, Boykin DW, Wilson WD. Water-mediated binding of agents that target the DNA minor groove. Journal of the American Chemical Society. 133: 10171-83. PMID 21627167 DOI: 10.1021/Ja202006U |
0.433 |
|
| 2011 |
Balasubramanian S, Hurley LH, Neidle S. Targeting G-quadruplexes in gene promoters: a novel anticancer strategy? Nature Reviews. Drug Discovery. 10: 261-75. PMID 21455236 DOI: 10.1038/Nrd3428 |
0.426 |
|
| 2011 |
Haider S, Joseph CG, Neidle S, Fierke CA, Fuchter MJ. On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis. Bioorganic & Medicinal Chemistry Letters. 21: 2129-32. PMID 21320778 DOI: 10.1016/J.Bmcl.2011.01.128 |
0.305 |
|
| 2011 |
Collie GW, Sparapani S, Parkinson GN, Neidle S. Structural basis of telomeric RNA quadruplex-acridine ligand recognition Journal of the American Chemical Society. 133: 2721-2728. PMID 21291211 DOI: 10.1021/Ja109767Y |
0.825 |
|
| 2011 |
Casagrande V, Salvati E, Alvino A, Bianco A, Ciammaichella A, D'Angelo C, Ginnari-Satriani L, Serrilli AM, Iachettini S, Leonetti C, Neidle S, Ortaggi G, Porru M, Rizzo A, Franceschin M, et al. N-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage. Journal of Medicinal Chemistry. 54: 1140-56. PMID 21280624 DOI: 10.1021/Jm1013665 |
0.454 |
|
| 2011 |
Campbell NH, Smith DL, Reszka AP, Neidle S, O'Hagan D. Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA Organic and Biomolecular Chemistry. 9: 1328-1331. PMID 21221451 DOI: 10.1039/C0Ob00886A |
0.457 |
|
| 2011 |
Ginnari-Satriani L, Casagrande V, Alvino A, Altieri A, Murat P, Defrancq E, Lombardo CM, Neidle S, Bianco A, Ortaggi G, Franceschin M. Effects of Protein Binding on DNA G-Quadruplex Structures International Review of Biophysical Chemistry. 2: 135-141. DOI: 10.15866/Irebic.V2I4.1525 |
0.493 |
|
| 2011 |
Welsh SJ, Lombardo CM, Valentine H, Neidle S. Abstract 4506: CL67: A novel G-quadruplex stabilising agent inhibits the HIF-1 pathway Cancer Research. 71: 4506-4506. DOI: 10.1158/1538-7445.Am2011-4506 |
0.35 |
|
| 2011 |
Rahman KM, Nahar K, Sander L, Bui TTT, Drake A, Lagah S, Walsh S, Fuente Mdl, Schätzlein AG, Neidle S, Thurston DE. Abstract 2517: Hybrid benzofused-biaryl polyamides with selective telomeric G-quadruplex stabilization potential Cancer Research. 71: 2517-2517. DOI: 10.1158/1538-7445.Am2011-2517 |
0.522 |
|
| 2011 |
Campbell NH, Karim NHA, Parkinson GN, Vilar R, Neidle S. Abstract 2326: The first crystal structure of a telomeric quadruplex DNA with a metal-containing ligand Cancer Research. 71: 2326-2326. DOI: 10.1158/1538-7445.Am2011-2326 |
0.433 |
|
| 2011 |
Husby J, Haider SM, Zinzella G, Thurston DE, Neidle S. Abstract 2323: Molecular modeling studies of the STAT3 homodimer:DNA complex Cancer Research. 71: 2323-2323. DOI: 10.1158/1538-7445.Am2011-2323 |
0.807 |
|
| 2011 |
Parkinson GN, Gunaratnam M, Li XW, Collie G, Reszka AP, Todd AR, Fletcher JA, Neidle S. Abstract 2310: Down-regulating BCL-2 gene expression in a resistant GIST cell line by a RNA G-quadruplex interacting small molecule ligand Cancer Research. 71: 2310-2310. DOI: 10.1158/1538-7445.Am2011-2310 |
0.722 |
|
| 2011 |
Fuchter MJ, Baud MGJ, Leiser T, Samlal S, Wong AC, Wood RJ, Gunaratnam M, Hughes SM, Buluwela L, Turlais F, Neidle S, Meyer-Almes F. Abstract B166: Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-B166 |
0.704 |
|
| 2011 |
Munnur DG, Mitchell E, Forsyth T, Teixeira S, Neidle S. Crystallographic studies of DNA minor groove binding drugs Acta Crystallographica Section a Foundations of Crystallography. 67: C285-C286. DOI: 10.1107/S0108767311092853 |
0.379 |
|
| 2010 |
Bejugam M, Gunaratnam M, Müller S, Sanders DA, Sewitz S, Fletcher JA, Neidle S, Balasubramanian S. Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines. Acs Medicinal Chemistry Letters. 1: 306-10. PMID 24900212 DOI: 10.1021/Ml100062Z |
0.727 |
|
| 2010 |
Lombardo CM, Martínez IS, Haider S, Gabelica V, De Pauw E, Moses JE, Neidle S. Structure-based design of selective high-affinity telomeric quadruplex-binding ligands. Chemical Communications (Cambridge, England). 46: 9116-8. PMID 21038041 DOI: 10.1039/C0Cc02917C |
0.651 |
|
| 2010 |
Lavrado J, Reszka AP, Moreira R, Neidle S, Paulo A. C-11 diamino cryptolepine derivatives NSC748392, NSC748393, and NSC748394: Anticancer profile and G-quadruplex stabilization Bioorganic and Medicinal Chemistry Letters. 20: 7042-7045. PMID 20952194 DOI: 10.1016/J.Bmcl.2010.09.110 |
0.466 |
|
| 2010 |
Hampel SM, Sidibe A, Gunaratnam M, Riou JF, Neidle S. Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells Bioorganic and Medicinal Chemistry Letters. 20: 6459-6463. PMID 20932753 DOI: 10.1016/J.Bmcl.2010.09.066 |
0.756 |
|
| 2010 |
Sparapani S, Haider SM, Doria F, Gunaratnam M, Neidle S. Rational design of acridine-based ligands with selectivity for human telomeric quadruplexes Journal of the American Chemical Society. 132: 12263-12272. PMID 20718414 DOI: 10.1021/Ja1003944 |
0.836 |
|
| 2010 |
Haider SM, Patel JS, Poojari CS, Neidle S. Molecular Modeling on Inhibitor Complexes and Active-Site Dynamics of Cytochrome P450 C17, a Target for Prostate Cancer Therapy Journal of Molecular Biology. 400: 1078-1098. PMID 20595043 DOI: 10.1016/J.Jmb.2010.05.069 |
0.328 |
|
| 2010 |
Sparapani S, Bellini S, Gunaratnam M, Haider SM, Andreani A, Rambaldi M, Locatelli A, Morigi R, Granaiola M, Varoli L, Burnelli S, Leoni A, Neidle S. Bis-guanylhydrazone diimidazo[1,2-a:1,2-c]pyrimidine as a novel and specific G-quadruplex binding motif. Chemical Communications (Cambridge, England). 46: 5680-2. PMID 20582382 DOI: 10.1039/C0Cc00020E |
0.831 |
|
| 2010 |
Collie GW, Parkinson GN, Neidle S, Rosu F, De Pauw E, Gabelica V. Electrospray mass spectrometry of telomeric RNA (TERRA) reveals the formation of stable multimeric G-quadruplex structures. Journal of the American Chemical Society. 132: 9328-34. PMID 20565109 DOI: 10.1021/Ja100345Z |
0.695 |
|
| 2010 |
Moses JE, Ritson DJ, Zhang F, Lombardo CM, Haider S, Oldham N, Neidle S. A click chemistry approach to C3 symmetric, G-quadruplex stabilising ligands. Organic & Biomolecular Chemistry. 8: 2926-30. PMID 20498912 DOI: 10.1039/C005055E |
0.672 |
|
| 2010 |
Collie GW, Haider SM, Neidle S, Parkinson GN. A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex Nucleic Acids Research. 38: 5569-5580. PMID 20413582 DOI: 10.1093/Nar/Gkq259 |
0.717 |
|
| 2010 |
Antonow D, Kaliszczak M, Kang GD, Coffils M, Tiberghien AC, Cooper N, Barata T, Heidelberger S, James CH, Zloh M, Jenkins TC, Reszka AP, Neidle S, Guichard SM, Jodrell DI, et al. Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1- c ][1,4]benzodiazepine (PBD) antitumor agents Journal of Medicinal Chemistry. 53: 2927-2941. PMID 20218628 DOI: 10.1021/Jm901722V |
0.407 |
|
| 2010 |
Haider S, Neidle S. Molecular modeling and simulation of G-quadruplexes and quadruplex-ligand complexes. Methods in Molecular Biology (Clifton, N.J.). 608: 17-37. PMID 20012413 DOI: 10.1007/978-1-59745-363-9_2 |
0.342 |
|
| 2010 |
Gunaratnam M, Neidle S. An evaluation cascade for G-quadruplex telomere targeting agents in human cancer cells. Methods in Molecular Biology (Clifton, N.J.). 613: 303-313. PMID 19997892 DOI: 10.1007/978-1-60327-418-0_19 |
0.73 |
|
| 2010 |
Neidle S. Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer Febs Journal. 277: 1118-1125. PMID 19951354 DOI: 10.1111/J.1742-4658.2009.07463.X |
0.496 |
|
| 2010 |
Hampel S, Gunaratnam M, Fuente Mdl, Schatzlein A, Neidle S. Abstract 739: Targeting pancreatic cancers with a quadruplex-binding small molecule Cancer Research. 70: 739-739. DOI: 10.1158/1538-7445.Am10-739 |
0.704 |
|
| 2010 |
Haque MR, Zinzalla G, Kaye SL, Haider S, Basu BP, Anderson J, Rahman KM, Antonow D, Essex S, Palmer J, Nkansah E, Hasan F, Morgenstern D, Wilderspin AF, Neidle S, et al. Abstract 5454: Novel STAT3:STAT3 small-molecule inhibitors as potential anticancer agents Cancer Research. 70: 5454-5454. DOI: 10.1158/1538-7445.Am10-5454 |
0.367 |
|
| 2010 |
Gunaratnam M, Collie G, Reszka A, Todd A, Parkinson G, Fletcher J, Neidle S. Abstract 3679: Targeting drug-resistant GIST cells with a quadruplex-binding small molecule Cancer Research. 70: 3679-3679. DOI: 10.1158/1538-7445.Am10-3679 |
0.814 |
|
| 2010 |
Bejugam M, Gunaratnam M, Müller S, Sanders DA, Sewitz S, Fletcher JA, Neidle S, Balasubramanian S. Correction to Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines Acs Medicinal Chemistry Letters. 1: 546-546. DOI: 10.1021/Ml100241W |
0.681 |
|
| 2010 |
Bejugam M, Gunaratnam M, Müller S, Sanders DA, Sewitz S, Fletcher JA, Neidle S, Balasubramanian S. Targeting the c-Kit promoter g-quadruplexes with 6-substituted indenoisoquinolines Acs Medicinal Chemistry Letters. 1: 306-310. DOI: 10.1021/ml100062z |
0.668 |
|
| 2010 |
Hampel S, de la Fuente M, Schatzlein A, Sidibe A, Riou J, Neidle S. 348 Targeting pancreatic cancers with a G-quadruplex binding small molecule European Journal of Cancer Supplements. 8: 111. DOI: 10.1016/S1359-6349(10)72055-3 |
0.386 |
|
| 2010 |
MCKENNA R, NEIDLE S, SERAFINOWSKI P. ChemInform Abstract: Structure of 5′-Chloro-3′,5′-dideoxyformycin A Monohydrate. The Effects of Protonation on Formycin Structure and Conformation. Cheminform. 22: no-no. DOI: 10.1002/chin.199114301 |
0.433 |
|
| 2009 |
Collie G, Reszka AP, Haider SM, Gabelica V, Parkinson GN, Neidle S. Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes Chemical Communications. 7482-7484. PMID 20024253 DOI: 10.1039/B901889A |
0.701 |
|
| 2009 |
Martino L, Pagano B, Fotticchia I, Neidle S, Giancola C. Shedding light on the interaction between TMPyP4 and human telomeric quadruplexes. The Journal of Physical Chemistry. B. 113: 14779-86. PMID 19824637 DOI: 10.1021/Jp9066394 |
0.459 |
|
| 2009 |
Hsu STD, Varnai P, Bugaut A, Reszka AP, Neidle S, Balasubramanian S. A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics Journal of the American Chemical Society. 131: 13399-13409. PMID 19705869 DOI: 10.1021/Ja904007P |
0.43 |
|
| 2009 |
Cuenca F, Moore MJB, Johnson K, Guyen B, De Cian A, Neidle S. Design, synthesis and evaluation of 4,5-di-substituted acridone ligands with high G-quadruplex affinity and selectivity, together with low toxicity to normal cells Bioorganic and Medicinal Chemistry Letters. 19: 5109-5113. PMID 19640709 DOI: 10.1016/J.Bmcl.2009.07.033 |
0.447 |
|
| 2009 |
Rahman KM, Reszka AP, Gunaratnam M, Haider SM, Howard PW, Fox KR, Neidle S, Thurston DE. Biaryl polyamides as a new class of DNA quadruplex-binding ligands Chemical Communications. 4097-4099. PMID 19568645 DOI: 10.1039/B902359C |
0.753 |
|
| 2009 |
Balasubramanian S, Neidle S. G-quadruplex nucleic acids as therapeutic targets Current Opinion in Chemical Biology. 13: 345-353. PMID 19515602 DOI: 10.1016/J.Cbpa.2009.04.637 |
0.451 |
|
| 2009 |
Neidle S. The structures of quadruplex nucleic acids and their drug complexes Current Opinion in Structural Biology. 19: 239-250. PMID 19487118 DOI: 10.1016/J.Sbi.2009.04.001 |
0.457 |
|
| 2009 |
Gunaratnam M, Green C, Moreira JB, Moorhouse AD, Kelland LR, Moses JE, Neidle S. G-quadruplex compounds and cis-platin act synergistically to inhibit cancer cell growth in vitro and in vivo. Biochemical Pharmacology. 78: 115-22. PMID 19475728 DOI: 10.1016/J.Bcp.2009.03.018 |
0.699 |
|
| 2009 |
Gunaratnam M, Swank S, Haider SM, Galesa K, Reszka AP, Beltran M, Cuenca F, Fletcher JA, Neidle S. Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule Journal of Medicinal Chemistry. 52: 3774-3783. PMID 19469547 DOI: 10.1021/Jm900424A |
0.699 |
|
| 2009 |
Haider SM, Neidle S. A molecular model for drug binding to tandem repeats of telomeric G-quadruplexes Biochemical Society Transactions. 37: 583-588. PMID 19442254 DOI: 10.1042/Bst0370583 |
0.47 |
|
| 2009 |
Micheli E, Lombardo CM, D'Ambrosio D, Franceschin M, Neidle S, Savino M. Selective G-quadruplex ligands: The significant role of side chain charge density in a series of perylene derivatives Bioorganic and Medicinal Chemistry Letters. 19: 3903-3908. PMID 19376705 DOI: 10.1016/J.Bmcl.2009.03.106 |
0.689 |
|
| 2009 |
Reed JE, White AJP, Neidle S, Vilar R. Effect of metal coordination on the interaction of substituted phenanthroline and pyridine ligands with quadruplex DNA Dalton Transactions. 2558-2568. PMID 19319401 DOI: 10.1039/B820086F |
0.715 |
|
| 2009 |
Campbell NH, Patel M, Tofa AB, Ghosh R, Parkinson GN, Neidle S. Selectivity in ligand recognition of G-quadruplex loops. Biochemistry. 48: 1675-80. PMID 19173611 DOI: 10.1021/Bi802233V |
0.706 |
|
| 2009 |
O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S. Bioactive pyridine-N-oxide disulfides from Allium stipitatum. Journal of Natural Products. 72: 360-5. PMID 19093848 DOI: 10.1021/Np800572R |
0.677 |
|
| 2009 |
Redman JE, Granadino-Roldán JM, Schouten JA, Ladame S, Reszka AP, Neidle S, Balasubramanian S. Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates. Organic & Biomolecular Chemistry. 7: 76-84. PMID 19081949 DOI: 10.1039/B814682A |
0.362 |
|
| 2009 |
Nguyen B, Neidle S, Wilson WD. A role for water molecules in DNA-ligand minor groove recognition. Accounts of Chemical Research. 42: 11-21. PMID 18798655 DOI: 10.1021/Ar800016Q |
0.429 |
|
| 2009 |
Collie G, Neidle S, Parkinson G. Targeting telomeric RNA quadruplexes Acta Crystallographica Section a Foundations of Crystallography. 65: s151-s151. DOI: 10.1107/S0108767309096950 |
0.629 |
|
| 2008 |
Drewe WC, Nanjunda R, Gunaratnam M, Beltran M, Parkinson GN, Reszka AP, Wilson WD, Neidle S. Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifs. Journal of Medicinal Chemistry. 51: 7751-67. PMID 19053833 DOI: 10.1021/jm801245v |
0.817 |
|
| 2008 |
Arola-Arnal A, Benet-Buchholz J, Neidle S, Vilar R. Effects of metal coordination geometry on stabilization of human telomeric quadruplex DNA by square-planar and square-pyramidal metal complexes. Inorganic Chemistry. 47: 11910-9. PMID 19053336 DOI: 10.1021/Ic8016547 |
0.384 |
|
| 2008 |
Drewe WC, Neidle S. Click chemistry assembly of G-quadruplex ligands incorporating a diarylurea scaffold and triazole linkers. Chemical Communications (Cambridge, England). 5295-7. PMID 18985188 DOI: 10.1039/B814576H |
0.404 |
|
| 2008 |
Zagotto G, Sissi C, Lucatello L, Pivetta C, Cadamuro SA, Fox KR, Neidle S, Palumbo M. Aminoacyl-anthraquinone conjugates as telomerase inhibitors: synthesis, biophysical and biological evaluation. Journal of Medicinal Chemistry. 51: 5566-74. PMID 18754611 DOI: 10.1021/Jm800160V |
0.458 |
|
| 2008 |
Parkinson GN, Cuenca F, Neidle S. Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes. Journal of Molecular Biology. 381: 1145-56. PMID 18619463 DOI: 10.1016/J.Jmb.2008.06.022 |
0.725 |
|
| 2008 |
Reed J, Gunaratnam M, Beltran M, Reszka AP, Vilar R, Neidle S. TRAP-LIG, a modified telomere repeat amplification protocol assay to quantitate telomerase inhibition by small molecules. Analytical Biochemistry. 380: 99-105. PMID 18534183 DOI: 10.1016/J.Ab.2008.05.013 |
0.793 |
|
| 2008 |
Moorhouse AD, Haider S, Gunaratnam M, Munnur D, Neidle S, Moses JE. Targeting telomerase and telomeres: a click chemistry approach towards highly selective G-quadruplex ligands. Molecular Biosystems. 4: 629-42. PMID 18493662 DOI: 10.1039/B801822G |
0.751 |
|
| 2008 |
Campbell NH, Parkinson GN, Reszka AP, Neidle S. Structural basis of DNA quadruplex recognition by an acridine drug Journal of the American Chemical Society. 130: 6722-6724. PMID 18457389 DOI: 10.1021/Ja8016973 |
0.718 |
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| 2008 |
Neidle S, Parkinson GN. Quadruplex DNA crystal structures and drug design Biochimie. 90: 1184-1196. PMID 18395014 DOI: 10.1016/J.Biochi.2008.03.003 |
0.727 |
|
| 2008 |
Haider S, Parkinson GN, Neidle S. Molecular dynamics and principal components analysis of human telomeric quadruplex multimers Biophysical Journal. 95: 296-311. PMID 18375510 DOI: 10.1529/Biophysj.107.120501 |
0.74 |
|
| 2008 |
Todd AK, Neidle S. The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements Nucleic Acids Research. 36: 2700-2704. PMID 18353860 DOI: 10.1093/Nar/Gkn078 |
0.341 |
|
| 2008 |
Cuenca F, Greciano O, Gunaratnam M, Haider S, Munnur D, Nanjunda R, Wilson WD, Neidle S. Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands Bioorganic and Medicinal Chemistry Letters. 18: 1668-1673. PMID 18243701 DOI: 10.1016/J.Bmcl.2008.01.050 |
0.739 |
|
| 2008 |
Zagotto G, Sissi C, Moro S, Dal Ben D, Parkinson GN, Fox KR, Neidle S, Palumbo M. Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives. Bioorganic & Medicinal Chemistry. 16: 354-61. PMID 17936629 DOI: 10.1016/J.Bmc.2007.09.040 |
0.731 |
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| 2008 |
Parkinson G, Neidle S, Campbell N. Ligand binding and structural rearrangements of quadruplexes containing human telomeric sequences Acta Crystallographica Section a Foundations of Crystallography. 64: C156-C156. DOI: 10.1107/S010876730809497X |
0.392 |
|
| 2007 |
Reed JE, Neidle S, Vilar R. Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum-phenanthroline complex. Chemical Communications (Cambridge, England). 4366-8. PMID 17957288 DOI: 10.1039/B709898G |
0.665 |
|
| 2007 |
Todd AK, Haider SM, Parkinson GN, Neidle S. Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter Nucleic Acids Research. 35: 5799-5808. PMID 17720713 DOI: 10.1093/Nar/Gkm609 |
0.698 |
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| 2007 |
Lee MP, Parkinson GN, Hazel P, Neidle S. Observation of the coexistence of sodium and calcium ions in a DNA G-quadruplex ion channel. Journal of the American Chemical Society. 129: 10106-7. PMID 17661470 DOI: 10.1021/Ja0740869 |
0.638 |
|
| 2007 |
Gunaratnam M, Greciano O, Martins C, Reszka AP, Schultes CM, Morjani H, Riou JF, Neidle S. Mechanism of acridine-based telomerase inhibition and telomere shortening Biochemical Pharmacology. 74: 679-689. PMID 17631279 DOI: 10.1016/J.Bcp.2007.06.011 |
0.727 |
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| 2007 |
Munde M, Lee M, Neidle S, Arafa R, Boykin DW, Liu Y, Bailly C, Wilson WD. Induced fit conformational changes of a "reversed amidine" heterocycle: optimized interactions in a DNA minor groove complex. Journal of the American Chemical Society. 129: 5688-98. PMID 17425312 DOI: 10.1021/Ja069003N |
0.431 |
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| 2007 |
Phan AT, Kuryavyi V, Burge S, Neidle S, Patel DJ. Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter. Journal of the American Chemical Society. 129: 4386-92. PMID 17362008 DOI: 10.1021/Ja068739H |
0.455 |
|
| 2007 |
Milroy LG, Zinzalla G, Prencipe G, Michel P, Ley SV, Gunaratnam M, Beltran M, Neidle S. Chemical variation of natural-product-like scaffolds: Design, synthesis, and biological activity of fused bicyclic acetal derivatives Angewandte Chemie - International Edition. 46: 2493-2496. PMID 17318936 DOI: 10.1002/Anie.200604688 |
0.644 |
|
| 2007 |
Martins C, Gunaratnam M, Stuart J, Makwana V, Greciano O, Reszka AP, Kelland LR, Neidle S. Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents. Bioorganic & Medicinal Chemistry Letters. 17: 2293-8. PMID 17276687 DOI: 10.1016/J.Bmcl.2007.01.056 |
0.749 |
|
| 2007 |
Parkinson GN, Ghosh R, Neidle S. Structural basis for binding of porphyrin to human telomeres Biochemistry. 46: 2390-2397. PMID 17274602 DOI: 10.1021/Bi062244N |
0.75 |
|
| 2007 |
White EW, Tanious F, Ismail MA, Reszka AP, Neidle S, Boykin DW, Wilson WD. Structure-specific recognition of quadruplex DNA by organic cations: influence of shape, substituents and charge. Biophysical Chemistry. 126: 140-53. PMID 16831507 DOI: 10.1016/J.Bpc.2006.06.006 |
0.5 |
|
| 2007 |
Reed JE, Neidle S, Vilar R. Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum-phenanthroline complex Chemical Communications. 4366-4368. DOI: 10.1039/b709898g |
0.662 |
|
| 2006 |
Moorhouse AD, Santos AM, Gunaratnam M, Moore M, Neidle S, Moses JE. Stabilization of G-quadruplex DNA by highly selective ligands via click chemistry. Journal of the American Chemical Society. 128: 15972-3. PMID 17165715 DOI: 10.1021/Ja0661919 |
0.746 |
|
| 2006 |
Redman JE, Ladame S, Reszka AP, Neidle S, Balasubramanian S. Discovery of G-quadruplex stabilizing ligands through direct ELISA of a one-bead-one-compound library. Organic & Biomolecular Chemistry. 4: 4364-9. PMID 17102882 DOI: 10.1039/B611716C |
0.398 |
|
| 2006 |
Moore MJ, Cuenca F, Searcey M, Neidle S. Synthesis of distamycin A polyamides targeting G-quadruplex DNA. Organic & Biomolecular Chemistry. 4: 3479-88. PMID 17036143 DOI: 10.1039/B607707B |
0.462 |
|
| 2006 |
Burge S, Parkinson GN, Hazel P, Todd AK, Neidle S. Quadruplex DNA: Sequence, topology and structure Nucleic Acids Research. 34: 5402-5415. PMID 17012276 DOI: 10.1093/Nar/Gkl655 |
0.725 |
|
| 2006 |
Evans DA, Neidle S. Virtual screening of DNA minor groove binders. Journal of Medicinal Chemistry. 49: 4232-8. PMID 16821782 DOI: 10.1021/Jm0601957 |
0.505 |
|
| 2006 |
Fernando H, Reszka AP, Huppert J, Ladame S, Rankin S, Venkitaraman AR, Neidle S, Balasubramanian S. A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene. Biochemistry. 45: 7854-60. PMID 16784237 DOI: 10.1021/Bi0601510 |
0.388 |
|
| 2006 |
Reed JE, Arnal AA, Neidle S, Vilar R. Stabilization of G-quadruplex DNA and inhibition of telomerase activity by square-planar nickel(II) complexes Journal of the American Chemical Society. 128: 5992-5993. PMID 16669641 DOI: 10.1021/Ja058509N |
0.708 |
|
| 2006 |
Hazel P, Parkinson GN, Neidle S. Predictive modelling of topology and loop variations in dimeric DNA quadruplex structures Nucleic Acids Research. 34: 2117-2127. PMID 16641317 DOI: 10.1093/Nar/Gkl182 |
0.658 |
|
| 2006 |
Hazel P, Parkinson GN, Neidle S. Topology variation and loop structural homology in crystal and simulated structures of a bimolecular DNA quadruplex Journal of the American Chemical Society. 128: 5480-5487. PMID 16620121 DOI: 10.1021/Ja058577+ |
0.713 |
|
| 2006 |
Le Sann C, Baron A, Mann J, van den Berg H, Gunaratnam M, Neidle S. New mustard-linked 2-aryl-bis-benzimidazoles with anti-proliferative activity. Organic & Biomolecular Chemistry. 4: 1305-12. PMID 16557319 DOI: 10.1039/B600567E |
0.69 |
|
| 2006 |
Ladame S, Schouten JA, Roldan J, Redman JE, Neidle S, Balasubramanian S. Exploring the recognition of quadruplex DNA by an engineered Cys2-His2 zinc finger protein. Biochemistry. 45: 1393-9. PMID 16445281 DOI: 10.1021/Bi050229X |
0.433 |
|
| 2006 |
Moore MJ, Schultes CM, Cuesta J, Cuenca F, Gunaratnam M, Tanious FA, Wilson WD, Neidle S. Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation. Journal of Medicinal Chemistry. 49: 582-99. PMID 16420044 DOI: 10.1021/Jm050555A |
0.749 |
|
| 2006 |
Franceschin M, Rossetti L, D'Ambrosio A, Schirripa S, Bianco A, Ortaggi G, Savino M, Schultes C, Neidle S. Natural and synthetic G-quadruplex interactive berberine derivatives Bioorganic and Medicinal Chemistry Letters. 16: 1707-1711. PMID 16377184 DOI: 10.1016/J.Bmcl.2005.12.001 |
0.5 |
|
| 2006 |
Campbell NH, Evans DA, Lee MP, Parkinson GN, Neidle S. Targeting the DNA minor groove with fused ring dicationic compounds: comparison of in silico screening and a high-resolution crystal structure. Bioorganic & Medicinal Chemistry Letters. 16: 15-9. PMID 16263285 DOI: 10.1016/J.Bmcl.2005.10.036 |
0.748 |
|
| 2006 |
Neidle S, Balasubramanian S. Quadruplex nucleic acids. The Royal Society of Chemistry. DOI: 10.1039/9781847555298 |
0.441 |
|
| 2005 |
Miao Y, Lee MP, Parkinson GN, Batista-Parra A, Ismail MA, Neidle S, Boykin DW, Wilson WD. Out-of-shape DNA minor groove binders: induced fit interactions of heterocyclic dications with the DNA minor groove. Biochemistry. 44: 14701-8. PMID 16274217 DOI: 10.1021/bi051791q |
0.649 |
|
| 2005 |
Rankin S, Reszka AP, Huppert J, Zloh M, Parkinson GN, Todd AK, Ladame S, Balasubramanian S, Neidle S. Putative DNA quadruplex formation within the human c-kit oncogene. Journal of the American Chemical Society. 127: 10584-9. PMID 16045346 DOI: 10.1021/Ja050823U |
0.689 |
|
| 2005 |
Todd AK, Johnston M, Neidle S. Highly prevalent putative quadruplex sequence motifs in human DNA Nucleic Acids Research. 33: 2901-2907. PMID 15914666 DOI: 10.1093/Nar/Gki553 |
0.369 |
|
| 2005 |
Burger AM, Dai F, Schultes CM, Reszka AP, Moore MJ, Double JA, Neidle S. The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. Cancer Research. 65: 1489-96. PMID 15735037 DOI: 10.1158/0008-5472.Can-04-2910 |
0.435 |
|
| 2005 |
Casely-Hayford MA, Pors K, Patterson LH, Gerner C, Neidle S, Searcey M. Truncated azinomycin analogues intercalate into DNA Bioorganic and Medicinal Chemistry Letters. 15: 653-656. PMID 15664831 DOI: 10.1016/J.Bmcl.2004.11.037 |
0.382 |
|
| 2004 |
Hazel P, Huppert J, Balasubramanian S, Neidle S. Loop-length-dependent folding of G-quadruplexes Journal of the American Chemical Society. 126: 16405-16415. PMID 15600342 DOI: 10.1021/Ja045154J |
0.407 |
|
| 2004 |
Harrison RJ, Reszka AP, Haider SM, Romagnoli B, Morrell J, Read MA, Gowan SM, Incles CM, Kelland LR, Neidle S. Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding. Bioorganic & Medicinal Chemistry Letters. 14: 5845-9. PMID 15501053 DOI: 10.1016/J.Bmcl.2004.09.037 |
0.453 |
|
| 2004 |
Mallena S, Lee MP, Bailly C, Neidle S, Kumar A, Boykin DW, Wilson WD. Thiophene-based diamidine forms a "super" at binding minor groove agent. Journal of the American Chemical Society. 126: 13659-69. PMID 15493923 DOI: 10.1021/Ja048175M |
0.421 |
|
| 2004 |
Ladame S, Schouten JA, Stuart J, Roldan J, Neidle S, Balasubramanian S. Tetrapeptides induce selective recognition for G-quadruplexes when conjugated to a DNA-binding platform. Organic & Biomolecular Chemistry. 2: 2925-31. PMID 15480456 DOI: 10.1039/B409698C |
0.479 |
|
| 2004 |
Schultes CM, Guyen B, Cuesta J, Neidle S. Synthesis, biophysical and biological evaluation of 3,6-bis-amidoacridines with extended 9-anilino substituents as potent G-quadruplex-binding telomerase inhibitors Bioorganic and Medicinal Chemistry Letters. 14: 4347-4351. PMID 15261300 DOI: 10.1016/J.Bmcl.2004.05.090 |
0.455 |
|
| 2004 |
Guyen B, Schultes CM, Hazel P, Mann J, Neidle S. Synthesis and evaluation of analogues of 10H-indolo[3,2-b]-quinoline as G-quadruplex stabilising ligands and potential inhibitors of the enzyme telomerase Organic and Biomolecular Chemistry. 2: 981-988. PMID 15034620 DOI: 10.1039/B316055F |
0.48 |
|
| 2004 |
Nguyen B, Hamelberg D, Bailly C, Colson P, Stanek J, Brun R, Neidle S, Wilson WD. Characterization of a Novel DNA Minor-Groove Complex Biophysical Journal. 86: 1028-1041. PMID 14747338 DOI: 10.1016/S0006-3495(04)74178-8 |
0.469 |
|
| 2004 |
Schultes C, Moore M, Guyen B, Neidle S. 435 Biophysical, biological, and in silico investigation of 3,6,9-trisubstituted acridines targeting human telomeric G-quadruplex DNA European Journal of Cancer Supplements. 2: 130. DOI: 10.1016/s1359-6349(04)80443-9 |
0.321 |
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| 2003 |
Keppler MD, James PL, Neidle S, Brown T, Fox KR. DNA sequence specificity of triplex-binding ligands European Journal of Biochemistry. 270: 4982-4992. PMID 14653824 DOI: 10.1046/J.1432-1033.2003.03901.X |
0.349 |
|
| 2003 |
Seaton A, Higgins C, Mann J, Baron A, Bailly C, Neidle S, van den Berg H. Mechanistic and anti-proliferative studies of two novel, biologically active bis-benzimidazoles. European Journal of Cancer (Oxford, England : 1990). 39: 2548-55. PMID 14602141 DOI: 10.1016/S0959-8049(03)00621-X |
0.393 |
|
| 2003 |
Incles CM, Schultes CM, Kelland LR, Neidle S. Acquired Cellular Resistance to Flavopiridol in a Human Colon Carcinoma Cell Line Involves Up-Regulation of the Telomerase Catalytic Subunit and Telomere Elongation. Sensitivity of Resistant Cells to Combination Treatment with a Telomerase Inhibitor Molecular Pharmacology. 64: 1101-1108. PMID 14573759 DOI: 10.1124/Mol.64.5.1101 |
0.337 |
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| 2003 |
Harrison RJ, Cuesta J, Chessari G, Read MA, Basra SK, Reszka AP, Morrell J, Gowan SM, Incles CM, Tanious FA, Wilson WD, Kelland LR, Neidle S. Trisubstituted acridine derivatives as potent and selective telomerase inhibitors. Journal of Medicinal Chemistry. 46: 4463-76. PMID 14521409 DOI: 10.1021/Jm0308693 |
0.484 |
|
| 2003 |
Johansson E, Parkinson GN, Denny WA, Neidle S. Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form Journal of Medicinal Chemistry. 46: 4009-4020. PMID 12954054 DOI: 10.1021/Jm030843B |
0.665 |
|
| 2003 |
Neidle S, Parkinson GN. The structure of telomeric DNA Current Opinion in Structural Biology. 13: 275-283. PMID 12831878 DOI: 10.1016/S0959-440X(03)00072-1 |
0.699 |
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| 2003 |
Joubert A, Sun XW, Johansson E, Bailly C, Mann J, Neidle S. Sequence-selective targeting of long stretches of the DNA minor groove by a novel dimeric bis-benzimidazole Biochemistry. 42: 5984-5992. PMID 12755600 DOI: 10.1021/Bi026926W |
0.4 |
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| 2003 |
Clark GR, Pytel PD, Squire CJ, Neidle S. Structure of the first parallel DNA quadruplex-drug complex. Journal of the American Chemical Society. 125: 4066-7. PMID 12670225 DOI: 10.1021/Ja0297988 |
0.474 |
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| 2003 |
Neidle S, Schneider B, Berman HM. Fundamentals of DNA and RNA structure. Methods of Biochemical Analysis. 44: 41-73. PMID 12647381 DOI: 10.1002/0471721204.Ch3 |
0.356 |
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| 2003 |
Bailly C, Chessari G, Carrasco C, Joubert A, Mann J, Wilson WD, Neidle S. Sequence-specific minor groove binding by bis-benzimidazoles: Water molecules in ligand recognition Nucleic Acids Research. 31: 1514-1524. PMID 12595560 DOI: 10.1093/Nar/Gkg237 |
0.451 |
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| 2003 |
Cuesta J, Read MA, Neidle S. The design of G-quadruplex ligands as telomerase inhibitors Mini Reviews in Medicinal Chemistry. 3: 11-21. PMID 12570851 DOI: 10.2174/1389557033405502 |
0.431 |
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| 2003 |
Haider SM, Parkinson GN, Neidle S. Structure of a G-quadruplex-ligand complex Journal of Molecular Biology. 326: 117-125. PMID 12547195 DOI: 10.1016/S0022-2836(02)01354-2 |
0.749 |
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| 2002 |
Nguyen B, Lee MPH, Hamelberg D, Joubert A, Bailly C, Brun R, Neidle S, Wilson WD. Strong binding in the DNA minor groove by an aromatic diamidine with a shape that does not match the curvature of the groove Journal of the American Chemical Society. 124: 13680-13681. PMID 12431090 DOI: 10.1021/Ja027953C |
0.433 |
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| 2002 |
Ladame S, Harrison RJ, Neidle S, Balasubramanian S. Solid-phase synthesis of symmetrical 3,6-bispeptide-acridone conjugates. Organic Letters. 4: 2509-12. PMID 12123363 DOI: 10.1021/Ol026130P |
0.322 |
|
| 2002 |
Neidle S, Parkinson G. Telomere maintenance as a target for anticancer drug discovery Nature Reviews Drug Discovery. 1: 383-393. PMID 12120414 DOI: 10.1038/Nrd793 |
0.652 |
|
| 2002 |
Haider S, Parkinson GN, Neidle S. Crystal structure of the potassium form of an Oxytricha nova G-quadruplex Journal of Molecular Biology. 320: 189-200. PMID 12079378 DOI: 10.1016/S0022-2836(02)00428-X |
0.685 |
|
| 2002 |
Parkinson GN, Lee MPH, Neidle S. Crystal structure of parallel quadruplexes from human telomeric DNA Nature. 417: 876-880. PMID 12050675 DOI: 10.1038/Nature755 |
0.714 |
|
| 2002 |
Gowan SM, Harrison JR, Patterson L, Valenti M, Read MA, Neidle S, Kelland LR. A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity Molecular Pharmacology. 61: 1154-1162. PMID 11961134 DOI: 10.1124/Mol.61.5.1154 |
0.429 |
|
| 2002 |
Morávek Z, Neidle S, Schneider B. Protein and drug interactions in the minor groove of DNA Nucleic Acids Research. 30: 1182-1191. PMID 11861910 DOI: 10.1093/Nar/30.5.1182 |
0.376 |
|
| 2002 |
Clark GR, Pytel PD, Squire CJ, Neidle S. Daunomycin/d(TGGGGT): the first crystal structure of a drug bound to a G4-quadruplex DNA telomere Acta Crystallographica Section a Foundations of Crystallography. 58: c56-c56. DOI: 10.1107/S0108767302087329 |
0.426 |
|
| 2002 |
Sun XW, Neidle S, Mann J. Synthesis of a novel dimeric bis-benzimidazole with site-selective DNA-binding properties Tetrahedron Letters. 43: 7239-7241. DOI: 10.1016/S0040-4039(02)01595-2 |
0.401 |
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| 2001 |
Li JL, Harrison RJ, Reszka AP, Brosh RM, Bohr VA, Neidle S, Hickson ID. Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands. Biochemistry. 40: 15194-202. PMID 11735402 DOI: 10.1021/Bi011067H |
0.486 |
|
| 2001 |
Olson WK, Bansal M, Burley SK, Dickerson RE, Gerstein M, Harvey SC, Heinemann U, Lu XJ, Neidle S, Shakked Z, Sklenar H, Suzuki M, Tung CS, Westhof E, Wolberger C, et al. A standard reference frame for the description of nucleic acid base-pair geometry. Journal of Molecular Biology. 313: 229-37. PMID 11601858 DOI: 10.1006/Jmbi.2001.4987 |
0.302 |
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| 2001 |
Neidle S. DNA minor-groove recognition by small molecules Natural Product Reports. 18: 291-309. PMID 11476483 DOI: 10.1039/A705982E |
0.363 |
|
| 2001 |
Keppler MD, Neidle S, Keith R F. Stabilisation of TG- and AG-containing antiparallel DNA triplexes by triplex-binding ligands Nucleic Acids Research. 29: 1935-1942. PMID 11328877 DOI: 10.1093/Nar/29.9.1935 |
0.371 |
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| 2001 |
Read M, Harrison RJ, Romagnoli B, Tanious FA, Gowan SH, Reszka AP, Wilson WD, Kelland LR, Neidle S. Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 98: 4844-9. PMID 11309493 DOI: 10.1073/Pnas.081560598 |
0.477 |
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| 2001 |
Mann J, Baron A, Opoku-Boahen Y, Johansson E, Parkinson G, Kelland LR, Neidle S. A new class of symmetric bisbenzimidazole-based DNA minor groove-binding agents showing antitumor activity Journal of Medicinal Chemistry. 44: 138-144. PMID 11170623 DOI: 10.1021/Jm000297B |
0.692 |
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| 2000 |
Neidle S, Read MA. G-quadruplex as therapeutic targets Biopolymers. 56: 195-208. PMID 11745111 DOI: 10.1002/1097-0282(2000)56:3<195::Aid-Bip10009>3.0.Co;2-5 |
0.466 |
|
| 2000 |
Simpson IJ, Lee M, Kumar A, Boykin DW, Neidle S. DNA minor groove interactions and the biological activity of 2,5-bis-[4-(N-alkylamidino)phenyl] furans Bioorganic and Medicinal Chemistry Letters. 10: 2593-2597. PMID 11128631 DOI: 10.1016/S0960-894X(00)00511-4 |
0.443 |
|
| 2000 |
Read MA, Neidle S. Structural characterization of a guanine-quadruplex ligand complex Biochemistry. 39: 13422-13432. PMID 11063579 DOI: 10.1021/Bi001584K |
0.381 |
|
| 2000 |
Parkinson GN, Skelly JV, Neidle S. Crystal structure of FMN-dependent nitroreductase from Escherichia coli B: A prodrug-activating enzyme Journal of Medicinal Chemistry. 43: 3624-3631. PMID 11020276 DOI: 10.1021/Jm000159M |
0.362 |
|
| 2000 |
Bennett M, Krah A, Wien F, Garman E, McKenna R, Sanderson M, Neidle S. A DNA-porphyrin minor-groove complex at atomic resolution: the structural consequences of porphyrin ruffling. Proceedings of the National Academy of Sciences of the United States of America. 97: 9476-81. PMID 10920199 DOI: 10.1073/Pnas.160271897 |
0.745 |
|
| 2000 |
Johansson E, Parkinson G, Neidle S. A new crystal form for the dodecamer C-G-C-G-A-A-T-T-C-G-C-G: symmetry effects on sequence-dependent DNA structure. Journal of Molecular Biology. 300: 551-61. PMID 10884351 DOI: 10.1006/Jmbi.2000.3907 |
0.691 |
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| 2000 |
Mazur S, Tanious FA, Ding D, Kumar A, Boykin DW, Simpson IJ, Neidle S, Wilson WD. A thermodynamic and structural analysis of DNA minor-groove complex formation. Journal of Molecular Biology. 300: 321-37. PMID 10873468 DOI: 10.1006/Jmbi.2000.3869 |
0.429 |
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| 2000 |
Neidle S, Harrison RJ, Reszka AP, Read MA. Structure-activity relationships among guanine-quadruplex telomerase inhibitors. Pharmacology & Therapeutics. 85: 133-9. PMID 10739868 DOI: 10.1016/S0163-7258(99)00065-0 |
0.408 |
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| 2000 |
Neidle S, Mann J, Rayner EJ, Baron A, Opoku-Boahen Y, Simpson IJ, Smith NJ, Fox KR, Hartley JA, Kelland LR. Symmetric bis-benzimidazoles, a new class of sequence-selective DNA-binding molecules Journal of the Chemical Society, Chemical Communications. 929-930. DOI: 10.2210/Pdb453D/Pdb |
0.396 |
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| 1999 |
Read MA, Wood AA, Harrison JR, Gowan SM, Kelland LR, Dosanjh HS, Neidle S. Molecular modeling studies on G-quadruplex complexes of telomerase inhibitors: Structure-activity relationships Journal of Medicinal Chemistry. 42: 4538-4546. PMID 10579817 DOI: 10.1021/Jm990287E |
0.483 |
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| 1999 |
Skelly JV, Sanderson MR, Suter DA, Baumann U, Read MA, Gregory DSJ, Bennett M, Hobbs SM, Neidle S. Crystal structure of human DT-diaphorase: a model for interaction with the cytotoxic prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954). Journal of Medicinal Chemistry. 42: 4325-4330. PMID 10543876 DOI: 10.1021/Jm991060M |
0.627 |
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| 1999 |
Harrison RJ, Gowan SM, Kelland LR, Neidle S. Human telomerase inhibition by substituted acridine derivatives. Bioorganic & Medicinal Chemistry Letters. 9: 2463-8. PMID 10498189 DOI: 10.1016/S0960-894X(99)00394-7 |
0.412 |
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| 1999 |
Keppler MD, Read MA, Perry PJ, Trent JO, Jenkins TC, Reszka AP, Neidle S, Fox KR. Stabilization of DNA triple helices by a series of mono- and disubstituted amidoanthraquinones. European Journal of Biochemistry / Febs. 263: 817-25. PMID 10469146 DOI: 10.1046/J.1432-1327.1999.00566.X |
0.456 |
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| 1999 |
Perry PJ, Read MA, Davies RT, Gowan SM, Reszka AP, Wood AA, Kelland LR, Neidle S. 2,7-Disubstituted amidofluorenone derivatives as inhibitors of human telomerase. Journal of Medicinal Chemistry. 42: 2679-84. PMID 10411488 DOI: 10.1021/Jm990084Q |
0.463 |
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| 1999 |
Aymami J, Nunn CM, Neidle S. DNA minor groove recognition of a non-self-complementary AT-rich sequence by a tris-benzimidazole ligand Nucleic Acids Research. 27: 2691-2698. PMID 10373586 DOI: 10.1093/Nar/27.13.2691 |
0.426 |
|
| 1999 |
Abrescia NG, Malinina L, Fernandez LG, Huynh-Dinh T, Neidle S, Subirana JA. Structure of the oligonucleotide d(CGTATATACG) as a site-specific complex with nickel ions. Nucleic Acids Research. 27: 1593-9. PMID 10075989 DOI: 10.1093/Nar/27.7.1593 |
0.343 |
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| 1999 |
Neidle S, Rayner EL, Simpson IJ, Smith NJ, Mann J, Baron A, Opoku-Boahen Y, Fox KR, Hartley JA, Kelland LR. Symmetric bis-benzimidazoles: new sequence-selective DNA-binding molecules Chemical Communications. 929-930. DOI: 10.1039/A901074B |
0.403 |
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| 1998 |
Perry PJ, Reszka AP, Wood AA, Read MA, Gowan SM, Dosanjh HS, Trent JO, Jenkins TC, Kelland LR, Neidle S. Human telomerase inhibition by regioisomeric disubstituted amidoanthracene-9,10-diones. Journal of Medicinal Chemistry. 41: 4873-84. PMID 9822556 DOI: 10.1021/Jm981067O |
0.503 |
|
| 1998 |
Nunn CM, Neidle S. Structure of the DNA decamer d(GGCAATTGCG) contains both major- and minor-groove binding G·(G·C) base triplets Acta Crystallographica Section D: Biological Crystallography. 54: 577-583. PMID 9761852 DOI: 10.1107/S090744499701559X |
0.454 |
|
| 1998 |
Venitt S, Crofton-Sleigh C, Agbandje M, Jenkins TC, Neidle S. Anthracene-9,10-diones as potential anticancer agents: bacterial mutation studies of amido-substituted derivatives reveal an unexpected lack of mutagenicity. Journal of Medicinal Chemistry. 41: 3748-52. PMID 9733500 DOI: 10.1021/Jm980167R |
0.343 |
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| 1998 |
Neidle S. New insights into sequence-dependent DNA structure. Nature Structural Biology. 5: 754-6. PMID 9731761 DOI: 10.1038/1780 |
0.392 |
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| 1998 |
Perry PJ, Gowan SM, Reszka AP, Polucci P, Jenkins TC, Kelland LR, Neidle S. 1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase. Journal of Medicinal Chemistry. 41: 3253-60. PMID 9703471 DOI: 10.1021/Jm9801105 |
0.327 |
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| 1998 |
Guerri A, Simpson IJ, Neidle S. Visualisation of extensive water ribbons and networks in a DNA minor-groove drug complex. Nucleic Acids Research. 26: 2873-8. PMID 9611230 DOI: 10.1093/Nar/26.12.2873 |
0.303 |
|
| 1998 |
Neidle S, Nunn CM. Crystal structures of nucleic acids and their drug complexes Natural Product Reports. 15: 1-15. PMID 9493396 DOI: 10.1039/A815001Y |
0.363 |
|
| 1998 |
Neidle S, Gaffney PRJ, Reese CB. myo‐Inositol 1,3,5‐Bicyclic Phosphate Acta Crystallographica Section C-Crystal Structure Communications. 54: 1191-1192. DOI: 10.1107/S0108270197017435 |
0.309 |
|
| 1997 |
Schneider B, Neidle S, Berman HM. Conformations of the sugar-phosphate backbone in helical DNA crystal structures. Biopolymers. 42: 113-24. PMID 19350745 DOI: 10.1002/(Sici)1097-0282(199707)42:1<113::Aid-Bip10>3.0.Co;2-O |
0.386 |
|
| 1997 |
Nunn CM, Trent JO, Neidle S. A model for the [C+-G · C](n) triple helix derived from observation of the C+-G · C base triplet in a crystal structure Febs Letters. 416: 86-89. PMID 9369239 DOI: 10.1016/S0014-5793(97)01130-7 |
0.391 |
|
| 1997 |
Wood AA, Nunn CM, Trent JO, Neidle S. Sequence-dependent crossed helix packing in the crystal structure of a B-DNA decamer yields a detailed model for the Holliday junction. Journal of Molecular Biology. 269: 827-41. PMID 9223644 DOI: 10.1006/Jmbi.1997.1089 |
0.38 |
|
| 1997 |
Sun D, Thompson B, Cathers BE, Salazar M, Kerwin SM, Trent JO, Jenkins TC, Neidle S, Hurley LH. Inhibition of human telomerase by a G-quadruplex-interactive compound. Journal of Medicinal Chemistry. 40: 2113-6. PMID 9216827 DOI: 10.1021/Jm970199Z |
0.388 |
|
| 1997 |
Clark GR, Boykin DW, Czarny A, Neidle S. Structure of a bis-amidinium derivative of hoechst 33258 complexed to dodecanucleotide d(CGCGAATTCGCG)2: the role of hydrogen bonding in minor groove drug-DNA recognition. Nucleic Acids Research. 25: 1510-5. PMID 9162901 DOI: 10.1093/Nar/25.8.1510 |
0.391 |
|
| 1997 |
Nunn CM, Garman E, Neidle S. Crystal structure of the DNA decamer d(CGCAATTGCG) complexed with the minor groove binding drug netropsin Biochemistry. 36: 4792-4799. PMID 9125500 DOI: 10.1021/Bi9628228 |
0.442 |
|
| 1997 |
Adzhubei AA, Adzhubei IA, Krasheninnikov IA, Neidle S. Non-random usage of 'degenerate' codons is related to protein three-dimensional structure. Febs Letters. 399: 78-82. PMID 8980124 DOI: 10.1016/S0014-5793(96)01287-2 |
0.318 |
|
| 1997 |
Nunn CM, Neidle S. Structure of the A-DNA octamer d(GGCATGCC) Acta Crystallographica Section D: Biological Crystallography. 53: 269-273. DOI: 10.1107/S0907444996014795 |
0.405 |
|
| 1997 |
Neidle S, Kelland L, Trent J, Simpson I, Boykin D, Kumar A, Wilson W. Cytotoxicity of bis(phenylamidinium)furan alkyl derivatives in human tumour cell lines: Relation to DNA minor groove binding Bioorganic & Medicinal Chemistry Letters. 7: 1403-1408. DOI: 10.1016/S0960-894X(97)00229-1 |
0.433 |
|
| 1997 |
Neidle S. Crystallographic insights into DNA minor groove recognition by drugs Biopolymers. 44: 105-121. DOI: 10.1002/(Sici)1097-0282(1997)44:1<105::Aid-Bip7>3.0.Co;2-Z |
0.329 |
|
| 1996 |
Thurston DE, Bose DS, Thompson AS, Howard PW, Leoni A, Croker SJ, Jenkins TC, Neidle S, Hartley JA, Hurley LH. Synthesis of Sequence-Selective C8-Linked Pyrrolo[2,1-c][1,4]benzodiazepine DNA Interstrand Cross-Linking Agents. The Journal of Organic Chemistry. 61: 8141-8147. PMID 11667802 DOI: 10.1021/Jo951631S |
0.383 |
|
| 1996 |
Clark GR, Squire CJ, Gray EJ, Leupin W, Neidle S. Designer DNA-binding drugs: the crystal structure of a meta-hydroxy analogue of Hoechst 33258 bound to d(CGCGAATTCGCG)2. Nucleic Acids Research. 24: 4882-9. PMID 9017011 DOI: 10.1093/Nar/24.24.4882 |
0.44 |
|
| 1996 |
Bates PJ, Laughton CA, Jenkins TC, Capaldi DC, Roselt PD, Reese CB, Neidle S. Efficient triple helix formation by oligodeoxyribonucleotides containing alpha- or beta-2-amino-5-(2-deoxy-D-ribofuranosyl) pyridine residues. Nucleic Acids Research. 24: 4176-84. PMID 8932369 DOI: 10.1093/Nar/24.21.4176 |
0.721 |
|
| 1996 |
Trent JO, Clark GR, Kumar A, Wilson WD, Boykin DW, Hall JE, Tidwell RR, Blagburn BL, Neidle S. Targeting the minor groove of DNA: crystal structures of two complexes between furan derivatives of berenil and the DNA dodecamer d(CGCGAATTCGCG)2. Journal of Medicinal Chemistry. 39: 4554-62. PMID 8917643 DOI: 10.1021/Jm9604484 |
0.476 |
|
| 1996 |
Clark GR, Gray EJ, Neidle S, Li YH, Leupin W. Isohelicity and phasing in drug--DNA sequence recognition: crystal structure of a tris(benzimidazole)--oligonucleotide complex. Biochemistry. 35: 13745-52. PMID 8901516 DOI: 10.1021/Bi960421M |
0.432 |
|
| 1996 |
Neidle S. The crystallization and structure analysis of oligonucleotide sequences. Methods in Molecular Biology (Clifton, N.J.). 56: 267-92. PMID 8781250 DOI: 10.1385/0-89603-259-0:267 |
0.314 |
|
| 1996 |
Laughton CA, Tanious F, Nunn CM, Boykin DW, Wilson WD, Neidle S. A crystallographic and spectroscopic study of the complex between d(CGCGAATTCGCG)2 and 2,5-bis(4-guanylphenyl)furan, an analogue of berenil. Structural origins of enhanced DNA-binding affinity. Biochemistry. 35: 5655-61. PMID 8639524 DOI: 10.1021/Bi952162R |
0.666 |
|
| 1996 |
Nunn CM, Neidle S. The high resolution crystal structure of the DNA decamer d(AGGCATGCCT) Journal of Molecular Biology. 256: 340-351. PMID 8594201 DOI: 10.1006/Jmbi.1996.0090 |
0.438 |
|
| 1996 |
Adzhubei AA, Laughton CA, Neidle S. An approach to protein homology modelling based on an ensemble of NMR structures: application to the Sox-5 HMG-box protein. Protein Engineering. 8: 615-25. PMID 8577691 DOI: 10.1093/Protein/8.7.615 |
0.596 |
|
| 1996 |
Bates PJ, Macaulay VM, McLean MJ, Jenkins TC, Reszka AP, Laughton CA, Neidle S. Characteristics of triplex-directed photoadduct formation by psoralen-linked oligodeoxynucleotides. Nucleic Acids Research. 23: 4283-9. PMID 7501447 DOI: 10.1093/Nar/23.21.4283 |
0.756 |
|
| 1996 |
Neidle S, Clark GR, Gray EJ, Li Y, Leupin W. Phasing in drug-DNA sequence recognition: structure of a tris(benzimidazole)–DNA complex Acta Crystallographica Section a Foundations of Crystallography. 52: C150-C150. DOI: 10.1107/S0108767396093257 |
0.369 |
|
| 1996 |
Wood AA, Nunn CM, Neidle S. Crystal structure of the B-DNA decamer d(CGCAATTGCG)2: sequence-dependent crossed helix packing Acta Crystallographica Section a Foundations of Crystallography. 52: C152-C152. DOI: 10.1107/S0108767396093178 |
0.365 |
|
| 1996 |
Neidle S, Chattopadhyaya JP, Hossain N, Papchikhin A. 2',3'-Dideoxy-3'-nitrothymidine and 2'-Propoxy-3'-nitrothymidine Acta Crystallographica Section C Crystal Structure Communications. 52: 3173-3177. DOI: 10.1107/S0108270196009481 |
0.306 |
|
| 1996 |
Neidle S, Murrer BA, Barnard CF. Conformational flexibility and its potential influence on metabolic reactions for the anti-tumour compound a-ammine-bd-bis(butyrato)-cf-dichloro-e-cyclohexylamine platinum(IV) Bioorganic & Medicinal Chemistry Letters. 6: 421-426. DOI: 10.1016/0960-894X(96)00046-7 |
0.347 |
|
| 1995 |
Nunn CM, Neidle S. The structure of chain-linked DNA as a possible model for the transcription bubble Nature Structural Biology. 2: 1060-1061. PMID 8846216 DOI: 10.1038/Nsb1295-1060 |
0.416 |
|
| 1995 |
Hardcastle IR, Rowlands MG, Houghton J, Parr IB, Potter GA, Jarman M, Edwards KJ, Laughton CA, Trent JO, Neidle S. Rationally designed analogues of tamoxifen with improved calmodulin antagonism Journal of Medicinal Chemistry. 38: 241-248. PMID 7830266 DOI: 10.1021/Jm00002A005 |
0.599 |
|
| 1995 |
Fox KR, Polucci P, Jenkins TC, Neidle S. A molecular anchor for stabilizing triple-helical DNA. Proceedings of the National Academy of Sciences of the United States of America. 92: 7887-91. PMID 7644509 DOI: 10.1073/Pnas.92.17.7887 |
0.437 |
|
| 1995 |
Nunn CM, Neidle S. Sequence-dependent drug binding to the minor groove of DNA: Crystal structure of the DNA dodecamer d(CGCAAATTTGCG)2 complexed with propamidine Journal of Medicinal Chemistry. 38: 2317-2325. PMID 7608897 DOI: 10.1021/Jm00013A008 |
0.455 |
|
| 1995 |
Ford KG, Neidle S. Perturbations in DNA structure upon interaction with porphyrins revealed by chemical probes, DNA footprinting and molecular modelling. Bioorganic & Medicinal Chemistry. 3: 671-7. PMID 7582945 DOI: 10.1016/0968-0896(95)00052-I |
0.448 |
|
| 1995 |
Macaulay VM, Bates PJ, McLean MJ, Rowlands MG, Jenkins TC, Ashworth A, Neidle S. Inhibition of aromatase expression by a psoralen-linked triplex-forming oligonucleotide targeted to a coding sequence. Febs Letters. 372: 222-8. PMID 7556673 DOI: 10.1016/0014-5793(95)00987-K |
0.682 |
|
| 1995 |
Spink N, Nunn CM, Vojtechovsky J, Berman HM, Neidle S. Crystal structure of a DNA decamer showing a novel pseudo four-way helix-helix junction Proceedings of the National Academy of Sciences of the United States of America. 92: 10767-10771. PMID 7479880 DOI: 10.1073/Pnas.92.23.10767 |
0.411 |
|
| 1995 |
Wood AA, Nunn CM, Czarny A, Boykin DW, Neidle S. Variability in DNA minor groove width recognised by ligand binding: the crystal structure of a bis-benzimidazole compound bound to the DNA duplex d(CGCGAATTCGCG)2. Nucleic Acids Research. 23: 3678-84. PMID 7478996 DOI: 10.1093/Nar/23.18.3678 |
0.464 |
|
| 1995 |
Bates PJ, Dosanjh HS, Kumar S, Jenkins TC, Laughton CA, Neidle S. Detection and kinetic studies of triplex formation by oligodeoxynucleotides using real-time biomolecular interaction analysis (BIA). Nucleic Acids Research. 23: 3627-32. PMID 7478988 DOI: 10.1093/Nar/23.18.3627 |
0.747 |
|
| 1995 |
Czarny A, Boykin DW, Wood AA, Nunn CM, Neidle S, Zhao M, Wilson WD. Analysis of van der Waals and Electrostatic Contributions in the Interactions of Minor Groove Binding Benzimidazoles with DNA Journal of the American Chemical Society. 117: 4716-4717. DOI: 10.1021/Ja00121A034 |
0.379 |
|
| 1995 |
Burke DF, Laughton CA, Snook CF, Neidle S, Potter GA, Jarman M. Active-site conformation of 17-(3-pyridyl)androsta-5,16-dien-3β-ol, a potent inhibitor of the P450 enzyme C17α-hydroxylase/C17-20 lyase Bioorganic and Medicinal Chemistry Letters. 5: 1125-1130. DOI: 10.1016/0960-894X(95)00178-V |
0.556 |
|
| 1994 |
Neidle S, Goodwin GH. A homology-based molecular model of the proline-rich homeodomain protein Prh, from haematopoietic cells. Febs Letters. 345: 93-8. PMID 7911091 DOI: 10.1016/0014-5793(94)00446-3 |
0.405 |
|
| 1994 |
Nunn CM, Jenkins TC, Neidle S. Crystal structure of γ-oxapentamidine complexes with d(CGCGAATTCGCG)2. The effects of drug structural change on DNA minor-groove recognition European Journal of Biochemistry. 226: 953-961. PMID 7813486 DOI: 10.1111/J.1432-1033.1994.00953.X |
0.436 |
|
| 1994 |
Jenkins TC, Hurley LH, Neidle S, Thurston DE. Structure of a covalent DNA minor groove adduct with a pyrrolobenzodiazepine dimer: evidence for sequence-specific interstrand cross-linking. Journal of Medicinal Chemistry. 37: 4529-37. PMID 7799403 DOI: 10.1021/Jm00052A012 |
0.415 |
|
| 1993 |
Jenkins TC, Lane AN, Neidle S, Brown DG. NMR and molecular modeling studies of the interaction of berenil and pentamidine with d(CGCAAATTTGCG)2. European Journal of Biochemistry. 213: 1175-84. PMID 8504811 DOI: 10.1111/J.1432-1033.1993.Tb17868.X |
0.428 |
|
| 1993 |
Laughton CA, Zvelebil MJ, Neidle S. A detailed molecular model for human aromatase. The Journal of Steroid Biochemistry and Molecular Biology. 44: 399-407. PMID 8476753 DOI: 10.1016/0960-0760(93)90243-P |
0.538 |
|
| 1993 |
Skelly JV, Edwards KJ, Jenkins TC, Neidle S. Crystal structure of an oligonucleotide duplex containing G·G base pairs: Influence of mispairing on DNA backbone conformation Proceedings of the National Academy of Sciences of the United States of America. 90: 804-808. PMID 8430089 DOI: 10.1073/Pnas.90.3.804 |
0.427 |
|
| 1993 |
Nunn CM, Jenkins TC, Neidle S. Crystal structure of d(CGCGAATTCGCG) complexed with propamidine, a short- chain homologue of the drug pentamidine Biochemistry. 32: 13838-13843. PMID 8268158 DOI: 10.1021/Bi00213A012 |
0.442 |
|
| 1993 |
Laughton CA, Neidle S. Prediction of the structure of the Y+.R-.R(+)-type DNA triple helix by molecular modelling. Nucleic Acids Research. 20: 6535-41. PMID 1480474 DOI: 10.1093/nar/20.24.6535 |
0.594 |
|
| 1993 |
Nunn CM, Spink N, Brown DG, Edwards KJ, Neidle S. Structural studies on DNA minor groove recognition by drugs Acta Crystallographica Section a Foundations of Crystallography. 49: c133-c133. DOI: 10.1107/S0108767378096154 |
0.374 |
|
| 1993 |
Greenidge PA, Laughton CA, Jenkins TC, Neidle S. Factors involved in guanine/cytosine (G/C) selectivity of DNA-binding drugs: a molecular modelling study of ligand interactions with a tyrT DNA sequence Journal of the Chemical Society, Faraday Transactions. 89: 2651. DOI: 10.1039/Ft9938902651 |
0.664 |
|
| 1992 |
Neidle S, Jenkins TC. Molecular modeling to study DNA intercalation by anti-tumor drugs. Methods in Enzymology. 203: 433-58. PMID 1762566 DOI: 10.1016/0076-6879(91)03024-B |
0.412 |
|
| 1992 |
Laughton CA, Neidle S. Molecular dynamics simulation of the DNA triplex d(TC)5.d(GA)5.d(C+T)5. Journal of Molecular Biology. 223: 519-29. PMID 1738161 DOI: 10.1016/0022-2836(92)90667-9 |
0.57 |
|
| 1992 |
Edwards KJ, Jenkins TC, Neidle S. Crystal Structure of a Pentamidine-Oligonucleotide Complex: Implications for DNA-Binding Properties Biochemistry. 31: 7104-7109. PMID 1643044 DOI: 10.1021/Bi00146A011 |
0.429 |
|
| 1992 |
Brown DG, Sanderson MR, Garman E, Neidle S. Crystal structure of a berenil-d(CGCAAATTTGCG) complex. An example of drug-DNA recognition based on sequence-dependent structural features. Journal of Molecular Biology. 226: 481-90. PMID 1640462 DOI: 10.1016/0022-2836(92)90962-J |
0.669 |
|
| 1992 |
Agbandje M, Jenkins TC, McKenna R, Reszka AP, Neidle S. Anthracene-9,10-diones as potential anticancer agents. Synthesis, DNA-binding, and biological studies on a series of 2,6-disubstituted derivatives. Journal of Medicinal Chemistry. 35: 1418-29. PMID 1573635 DOI: 10.1021/Jm00086A010 |
0.601 |
|
| 1992 |
Neidle S. Minor-groove width and accessibility in B-DNA drug and protein complexes. Febs Letters. 298: 97-9. PMID 1544428 DOI: 10.1016/0014-5793(92)80030-K |
0.362 |
|
| 1992 |
Edwards KJ, Brown DG, Spink N, Skelly JV, Neidle S. Molecular structure of the B-DNA dodecamer d(CGCAAATTTGCG)2. An examination of propeller twist and minor-groove water structure at 2.2 A resolution. Journal of Molecular Biology. 226: 1161-73. PMID 1518049 DOI: 10.1016/0022-2836(92)91059-X |
0.356 |
|
| 1992 |
Edwards KJ, Laughton CA, Neidle S. A molecular modeling study of the interactions between the antiestrogen drug tamoxifen and several derivatives, and the calcium-binding protein calmodulin Journal of Medicinal Chemistry. 35: 2753-2761. PMID 1322985 DOI: 10.1021/Jm00093A006 |
0.584 |
|
| 1992 |
Edwards KJ, Laughton CA, Neidle S. A note on the conformational flexibility of the antiestrogenic drug tamoxifen: preferred conformations in the free state and bound to the protein calmodulin Acta Crystallographica Section B. 48: 511-514. DOI: 10.1107/S0108768191014830 |
0.492 |
|
| 1992 |
McKenna R, Agbandje M, Neidle S. Structure of 9-amino-2,7-di-tert-butylacridine Acta Crystallographica Section C Crystal Structure Communications. 48: 188-190. DOI: 10.1107/S0108270191009113 |
0.447 |
|
| 1992 |
Bose DS, Thompson AS, Smellie M, Berardini MD, Hartley JA, Jenkins TC, Neidle S, Thurston DE. Effect of linker length on DNA-binding affinity, cross-linking efficiency and cytotoxicity of C8-linked pyrrolobenzodiazepine dimers Journal of the Chemical Society, Chemical Communications. 1518-1520. DOI: 10.1039/C39920001518 |
0.397 |
|
| 1992 |
Bose DS, Thompson AS, Ching J, Hartley JA, Berardini MD, Jenkins TC, Neidle S, Hurley LH, Thurston DE. Rational design of a highly efficient irreversible DNA interstrand cross-linking agent based on the pyrrolobenzodiazepine ring system Journal of the American Chemical Society. 114: 4939-4941. DOI: 10.1021/Ja00038A089 |
0.328 |
|
| 1991 |
Orozco M, Laughton CA, Herzyk P, Neidle S. Molecular-mechanics modelling of drug-DNA structures; the effects of differing dielectric treatment on helix parameters and comparison with a fully solvated structural model. Journal of Biomolecular Structure & Dynamics. 8: 359-73. PMID 2176506 DOI: 10.1080/07391102.1990.10507810 |
0.607 |
|
| 1991 |
Lane AN, Jenkins TC, Brown T, Neidle S. Interaction of berenil with the EcoRI dodecamer d(CGCGAATTCGCG)2 in solution studied by NMR. Biochemistry. 30: 1372-85. PMID 1991117 DOI: 10.1021/Bi00219A030 |
0.386 |
|
| 1991 |
McKenna R, Neidle S, Wilson WD. Structures of 1-(3,3-dimethylamino)propyl naphtho[2,1-b]thiophene-4- carboxylate and N-(3,3-dimethylamino)propyl-8-methoxynaphtho[2,1- b]thiophene-4-carboxamide, intercalators into double-helical DNA. Acta Crystallographica. Section C, Crystal Structure Communications. 47: 2511-3. PMID 1805872 DOI: 10.1107/S0108270191005991 |
0.467 |
|
| 1991 |
Laughton C, Neidle S. DNA triple helices. A molecular dynamics study Journal De Chimie Physique. 88: 2597-2603. DOI: 10.1051/jcp/1991882597 |
0.549 |
|
| 1990 |
Aggarwal AK, Islam SA, Neidle S. Computer modelling studies of the covalent interactions between DNA and the enantiomers of anti-7,8-diol,9,10-epoxy-benzo[a]pyrene. Journal of Biomolecular Structure & Dynamics. 1: 873-81. PMID 6443878 DOI: 10.1080/07391102.1983.10507490 |
0.528 |
|
| 1990 |
Hudson BD, Kuroda R, Denny WA, Neidle S. Crystallographic and molecular mechanics calculations on the anti-tumor drugs N-[(2-dimethylamino)ethyl]-and N-[(2-dimethyl-amino)butyl]-9-aminoacridine-4-carboxamides and their dications: implications for models of DNA-binding. Journal of Biomolecular Structure & Dynamics. 5: 145-58. PMID 3271463 DOI: 10.1080/07391102.1987.10506382 |
0.382 |
|
| 1990 |
Webster GD, Sanderson MR, Skelly JV, Neidle S, Swann PF, Li BF, Tickle IJ. Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG). Proceedings of the National Academy of Sciences of the United States of America. 87: 6693-7. PMID 2395870 DOI: 10.1073/Pnas.87.17.6693 |
0.66 |
|
| 1990 |
Laughton CA, McKenna R, Neidle S, Jarman M, McCague R, Rowlands MG. Crystallographic and molecular modeling studies on 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione and its butyl analogue, inhibitors of mammalian aromatase. Comparison with natural substrates: prediction of enantioselectivity for N-alkyl derivatives. Journal of Medicinal Chemistry. 33: 2673-9. PMID 2391706 DOI: 10.1021/Jm00171A052 |
0.661 |
|
| 1990 |
Laughton CA, Neidle S. Inhibitors of the P450 enzymes aromatase and lyase. Crystallographic and molecular modeling studies suggest structural features of pyridylacetic acid derivatives responsible for differences in enzyme inhibitory activity. Journal of Medicinal Chemistry. 33: 3055-60. PMID 2231605 DOI: 10.1021/Jm00173A023 |
0.596 |
|
| 1990 |
Laughton CA, Neidle S, Zvelebil MJ, Sternberg MJ. A molecular model for the enzyme cytochrome P450(17 alpha), a major target for the chemotherapy of prostatic cancer. Biochemical and Biophysical Research Communications. 171: 1160-7. PMID 2222435 DOI: 10.1016/0006-291X(90)90806-X |
0.557 |
|
| 1990 |
Clark GR, Brown DG, Sanderson MR, Chwalinski T, Neidle S, Veal JM, Jones RL, Wilson WD, Zon G, Garman E. Crystal and solution structures of the oligonucleotide d(ATGCGCAT)2: a combined X-ray and NMR study. Nucleic Acids Research. 18: 5521-8. PMID 2216724 DOI: 10.1093/Nar/18.18.5521 |
0.605 |
|
| 1990 |
Laughton CA, Jenkins TC, Fox KR, Neidle S. Interaction of berenil with the tyrT DNA sequence studied by footprinting and molecular modelling. Implications for the design of sequence-specific DNA recognition agents. Nucleic Acids Research. 18: 4479-88. PMID 2167469 DOI: 10.1093/Nar/18.15.4479 |
0.644 |
|
| 1990 |
McKenna R, Neidle S, Serafinowski P. Structure of 5'-chloro-3',5'-dideoxyformycin A monohydrate. The effects of protonation on formycin structure and conformation Acta Crystallographica Section C Crystal Structure Communications. 46: 2448-2450. DOI: 10.1107/S0108270190010630 |
0.462 |
|
| 1990 |
Brown D, Sanderson M, Skelly J, Jenkins T, Brown T, Garman E, Stuart D, Neidle S. Crystal structure of a berenil-dodecanucleotide complex: the role of water in sequence-specific ligand binding. The Embo Journal. 9: 1329-1334. DOI: 10.1002/J.1460-2075.1990.Tb08242.X |
0.624 |
|
| 1989 |
Bell A, Brown JR, Neidle S. Thermodynamic studies on the interactions of di-substituted anthraquinones with DNA. Biochemical Pharmacology. 38: 216-7. PMID 2910305 DOI: 10.1016/0006-2952(89)90174-3 |
0.366 |
|
| 1989 |
McKenna R, Beveridge AJ, Jenkins TC, Neidle S, Denny WA. Molecular modelling of DNA-antitumour drug intercalation interactions: correlation of structural and energetic features with biological properties for a series of phenylquinoline-8-carboxamide compounds. Molecular Pharmacology. 35: 720-8. PMID 2725476 |
0.51 |
|
| 1989 |
McKenna R, Neidle S, Kuroda R, Fox BW. Structures of three DNA cross-linking agents, ethane-1,2-di(methylsulfonate), propane-1,3-di(methylsulfonate) and n-butane-1,4-di(methylsulfonate). Acta Crystallographica. Section C, Crystal Structure Communications. 45: 311-4. PMID 2558689 DOI: 10.1107/S0108270188011291 |
0.454 |
|
| 1989 |
Skelly JV, Suter DA, Knox RJ, Garman E, Stuart DI, Sanderson MR, Roberts JJ, Neidle S. Preliminary crystallographic data for NAD(P)H quinone reductase isolated from the Walker 256 rat carcinoma cell line. Journal of Molecular Biology. 205: 623-4. PMID 2494346 DOI: 10.1016/0022-2836(89)90233-7 |
0.57 |
|
| 1989 |
Deadman JJ, Jarman M, McCague R, McKenna R, Neidle S. A benzoquinone Di-imine from the oxidation of pentafluoroaniline by hypochlorite. X-Ray crystal structure and possible formation via pentafluorophenylnitrene Journal of the Chemical Society-Perkin Transactions 1. 971-975. DOI: 10.1039/P29890000971 |
0.482 |
|
| 1989 |
DEADMAN JJ, JARMAN M, MCCAGUE R, MCKENNA R, NEIDLE S. ChemInform Abstract: A Benzoquinone Diimine from the Oxidation of Pentafluoroaniline by Hypochlorite. X-Ray Crystal Structure and Possible Formation via Pentafluorophenylnitrene. Cheminform. 20. DOI: 10.1002/chin.198947152 |
0.385 |
|
| 1988 |
Collier DA, Neidle S. Synthesis, molecular modeling, DNA binding, and antitumor properties of some substituted amidoanthraquinones. Journal of Medicinal Chemistry. 31: 847-57. PMID 3351863 DOI: 10.1021/Jm00399A028 |
0.433 |
|
| 1988 |
McKenna R, Jenkins TC, Neidle S. Structures of the anticancer compounds N-(2-hydroxyethyl)-2-(3-nitro-1,2,4-triazol-1-yl)-acetamide (RB-6110) and 5-(1-aziridinyl)-3-nitro-1-(3-oxo-1-butyl)-1,2,4- triazole (RB-6162). Acta Crystallographica. Section B, Structural Science. 44: 672-6. PMID 3271560 |
0.4 |
|
| 1988 |
McCague R, Leung O, Jarman M, Kuroda R, Neidle S, Webster G. The role of the 2-methyl substituent in governing stereoselective formation of the E isomer in the synthesis of 4-hydroxy-2-methyltamoxifen (1-{4-[2-(di-methylamino)ethoxy]phenyl}-1-(4-hydroxy-2-methylphenyl)-phenylbut-1-ene) Journal of the Chemical Society-Perkin Transactions 1. 1201-1208. DOI: 10.1039/P29880001201 |
0.301 |
|
| 1988 |
Wilson WD, Strekowski L, Tanious FA, Watson RA, Mokrosz JL, Strekowska A, Webster GD, Neidle S. Binding of unfused aromatic cations to DNA. The influence of molecular twist on intercalation Journal of the American Chemical Society. 110: 8292-8299. DOI: 10.1021/Ja00233A003 |
0.443 |
|
| 1987 |
Ford KG, Pearl LH, Neidle S. Molecular modelling of the interactions of tetra-(4-N-methylpyridyl) porphin with TA and CG sites on DNA. Nucleic Acids Research. 15: 6553-62. PMID 3627998 DOI: 10.1093/Nar/15.16.6553 |
0.394 |
|
| 1987 |
Pearl LH, Skelly JV, Hudson BD, Neidle S. The crystal structure of the DNA-binding drug berenil: molecular modelling studies of berenil-DNA complexes. Nucleic Acids Research. 15: 3469-78. PMID 3575097 DOI: 10.1093/Nar/15.8.3469 |
0.423 |
|
| 1987 |
Ford K, Fox KR, Neidle S, Waring MJ. DNA sequence preferences for an intercalating porphyrin compound revealed by footprinting. Nucleic Acids Research. 15: 2221-34. PMID 3562226 DOI: 10.1093/Nar/15.5.2221 |
0.418 |
|
| 1987 |
Pearl LH, Neidle S. Origins of stereospecificity in DNA damage by anti-benzo[a]pyrene diol-epoxides. A molecular modelling study. Febs Letters. 209: 269-76. PMID 3098581 DOI: 10.1016/0014-5793(86)81126-7 |
0.39 |
|
| 1987 |
Neidle S, Pearl LH, Skelly JV. DNA structure and perturbation by drug binding. The Biochemical Journal. 243: 1-13. PMID 3038075 DOI: 10.1042/Bj2430001 |
0.401 |
|
| 1987 |
Herzyk P, Beveridge A, Neidle S. Conformational properties of 3'-azido-3'deoxy-thymidine (AZT), an inhibitor of HIV reverse transcriptase. Biochemical and Biophysical Research Communications. 145: 1356-61. PMID 2440430 DOI: 10.1016/0006-291X(87)91587-7 |
0.328 |
|
| 1987 |
Neidle S, Sanderson MR. Nucleic acid binding drugs. XVI. Structure of (7R)-trans-7,11-di-O-acetyl-4-demethoxydaunomycinone, an analogue of the antitumour compound daunomycin Acta Crystallographica Section C Crystal Structure Communications. 43: 681-683. DOI: 10.1107/S0108270187094538 |
0.6 |
|
| 1987 |
McKenna R, Kuroda R, Neidle S, Serafinowski P. A structural study of 3'-deoxytubercidin and 3-deaza-3'-deoxyadenosine Acta Crystallographica Section C Crystal Structure Communications. 43: 1790-1793. DOI: 10.1107/S0108270187090164 |
0.488 |
|
| 1987 |
Abraham ZHL, Neidle S, Acheson RM. Nucleic acid binding drugs. XVII. Structures of 4-substituted analogues of the antitumour drug amsacrine Acta Crystallographica Section C Crystal Structure Communications. 43: 1992-1995. DOI: 10.1107/S0108270187089327 |
0.303 |
|
| 1987 |
McKenna R, Neidle S, Serafinowski P. The structure of 3'-deoxyformycin hydrochloride Acta Crystallographica Section C Crystal Structure Communications. 43: 2358-2361. DOI: 10.1107/S0108270187087766 |
0.484 |
|
| 1987 |
Hudson BD, Neidle S. Nucleic acid binding drugs. 18: Calculated charges for a DNA intercalation complex; a study of the relative influence of polarization and conformational effects International Journal of Biological Macromolecules. 9: 193-196. DOI: 10.1016/0141-8130(87)90052-3 |
0.322 |
|
| 1986 |
Neidle S, Webster GD, Baguley BC, Denny WA. Nucleic acid binding drugs--XIV. The crystal structure of 1-methyl amsacrine hydrochloride; relationships to DNA-binding ability and anti-tumour activity. Biochemical Pharmacology. 35: 3915-21. PMID 3778515 DOI: 10.1016/0006-2952(86)90004-3 |
0.427 |
|
| 1986 |
Fox KR, Waring MJ, Brown JR, Neidle S. DNA sequence preferences for the anti-cancer drug mitoxanthrone and related anthraquinones revealed by DNase I footprinting. Febs Letters. 202: 289-94. PMID 3720951 DOI: 10.1016/0014-5793(86)80703-7 |
0.407 |
|
| 1985 |
Kuroda R, Cutbush S, Neidle S, Leung OT. Structural studies on some tamoxifen derivatives. Journal of Medicinal Chemistry. 28: 1497-503. PMID 4045925 DOI: 10.1002/Chin.198606335 |
0.376 |
|
| 1985 |
Islam SA, Neidle S, Gandecha BM, Partridge M, Patterson LH, Brown JR. Comparative computer graphics and solution studies of the DNA interaction of substituted anthraquinones based on doxorubicin and mitoxantrone. Journal of Medicinal Chemistry. 28: 857-64. PMID 4009608 DOI: 10.1002/Chin.198544340 |
0.417 |
|
| 1985 |
Abraham ZHL, Cutbush SD, Kuroda R, Neidle S, Acheson RM, Taylor GN. Nucleic acid binding drugs. Part 12. X-Ray crystallographic and conformational studies on the anti-cancer drug m-AMSA and its mesyl derivative Journal of the Chemical Society-Perkin Transactions 1. 16: 461-465. DOI: 10.1039/P29850000461 |
0.344 |
|
| 1985 |
Bales JR, Mazid MA, Sadler PJ, Aggarwal A, Kuroda R, Neidle S, Gilmour DW, Peart BJ, Ramsden CA. Platinum(II) complexes of nitroimidazoles: synthesis, characterisation, and X-ray crystal structures of cis-dichlorobis[1-(2′-hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole]platinum(II) and trans-dichlorobis[1-(2′-hydroxy-3′-methoxypropyl)-2-nitroimidazole]platinum(II) Journal of the Chemical Society-Dalton Transactions. 795-802. DOI: 10.1039/Dt9850000795 |
0.525 |
|
| 1985 |
BALES JR, MAZID MA, SADLER PJ, AGGARWAL A, KURODA R, NEIDLE S, GILMOUR DW, PEART BJ, RAMSDEN CA. ChemInform Abstract: PLATINUM(II) COMPLEXES OF NITROIMIDAZOLES: SYNTHESIS, CHARACTERIZATION, AND X-RAY CRYSTAL STRUCTURES OF CIS-DICHLOROBIS(1-(2′-HYDROXYETHYL)-2-HYDROXYMETHYL-5-NITROIMIDAZOLE)PLATINUM(II) AND TRANS-DICHLOROBIS(1-(2′-HYDROXY-3′-METHOXYPR Chemischer Informationsdienst. 16. DOI: 10.1002/Chin.198532336 |
0.448 |
|
| 1984 |
Aggarwal A, Islam SA, Kuroda R, Neidle S. X-ray crystallographic analysis of a ternary intercalation complex between proflavine and the dinucleoside monophosphates CpA and UpG. Biopolymers. 23: 1025-41. PMID 6733246 DOI: 10.1002/Bip.360230605 |
0.594 |
|
| 1984 |
Millican TA, Mock GA, Chauncey MA, Patel TP, Eaton MA, Gunning J, Cutbush SD, Neidle S, Mann J. Synthesis and biophysical studies of short oligodeoxynucleotides with novel modifications: a possible approach to the problem of mixed base oligodeoxynucleotide synthesis. Nucleic Acids Research. 12: 7435-53. PMID 6548562 DOI: 10.1093/Nar/12.19.7435 |
0.334 |
|
| 1983 |
Islam SA, Neidle S, Gandecha BM, Brown JR. Experimental and computer graphics simulation analyses of the DNA interaction of 1,8-bis-(2-diethylaminoethylamino)-anthracene-9,10-dione, a compound modelled on doxorubicin. Biochemical Pharmacology. 32: 2801-8. PMID 6626250 DOI: 10.1016/0006-2952(83)90095-3 |
0.444 |
|
| 1983 |
Aggarwal A, Islam SA, Kuroda R, Sanderson MR, Neidle S, Berman HM. The structure of the ribodinucleoside monophosphate guanylyl-3',5'-cytidine as its ammonium octahydrate salt Acta Crystallographica Section B Structural Science. 39: 98-104. DOI: 10.1107/S0108768183002074 |
0.6 |
|
| 1983 |
Kuroda R, Neidle S, Ismail IM, Sadler PJ. X-Ray crystal and molecular structure of cis(NN′), trans(OO′)-bis-(2-aminoethanolato)-cis-dichloroplatinum(IV) dihydrate. The relationship of anti-tumour activity to ring closure Journal of the Chemical Society-Dalton Transactions. 823-825. DOI: 10.1039/Dt9830000823 |
0.304 |
|
| 1982 |
Neidle S, Subbiah A, Mason A, Islam SA. Molecular structures of three hydroxyl derivatives of the hepatic carcinogen acetylaminofluorene. Evidence for preferred orientation of the acetylamino side-chain. Carcinogenesis. 2: 901-7. PMID 7296773 DOI: 10.1093/Carcin/2.9.901 |
0.345 |
|
| 1982 |
Takusagawa F, Dabrow M, Neidle S, Berman HM. The structure of a pseudo intercalated complex between actinomycin and the DNA binding sequence d(GpC) Nature. 296: 466-469. PMID 7063043 DOI: 10.1038/296466A0 |
0.332 |
|
| 1982 |
Kuroda R, Neidle S, Riordan JM, Sakai TT. X-ray crystallographic analysis of 3-(2′-phenyl-2,4′-bithiazole-4-carboxamido)propyldimethylsulphonium iodide, an analogue of the DNA-binding portion of bleomycin A2 Nucleic Acids Research. 10: 4753-4763. PMID 6182526 DOI: 10.1093/Nar/10.15.4753 |
0.414 |
|
| 1982 |
Neidle S. The molecular basis for the action of some DNA-binding drugs. Progress in Medicinal Chemistry. 16: 151-221. PMID 95595 DOI: 10.1016/S0079-6468(08)70188-7 |
0.334 |
|
| 1982 |
Shieh HS, Berman HM, Neidle S, Taylor G, Sanderson M. The structure of a hydrated 1:2 complex of adenylyl(3'-5')adenosine–proflavine hemisulphate Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry. 38: 523-531. DOI: 10.1107/S0567740882003318 |
0.736 |
|
| 1982 |
Kuroda R, Sanderson MR, Neidle S, Reese CB. Crystal structure of 1-(mesityl-2-sulphonyl)-3-nitro-1,2,4-triazole Journal of the Chemical Society, Perkin Transactions 2. 617-620. DOI: 10.1039/P29820000617 |
0.616 |
|
| 1982 |
KURODA R, SANDERSON MR, NEIDLE S, REESE CB. ChemInform Abstract: CRYSTAL STRUCTURE OF 1-(MESITYL-2-SULFONYL)-3-NITRO-1,2,4-TRIAZOLE Chemischer Informationsdienst. 13. DOI: 10.1002/chin.198233067 |
0.58 |
|
| 1981 |
Neidle S. New twists to DNA and DNA-carcinogen interactions. Nature. 292: 292-3. PMID 7254328 DOI: 10.1038/292292A0 |
0.36 |
|
| 1980 |
Pinto MAFDR, Sadler PJ, Neidle S, Sanderson MR, Subbiah A, Kuroda R. A novel di-platinum(II) octaphosphite complex showing metal–metal bonding and intense luminescence; a potential probe for basic proteins. X-Ray crystal and molecular structure Journal of the Chemical Society, Chemical Communications. 13-15. DOI: 10.1039/C39800000013 |
0.613 |
|
| 1979 |
Neidle S, Taylor G, Sanderson M. A 1:2 crystalline complex of ApA:proflavine: a model for binding to single-stranded regions in RNA. Nucleic Acids Research. 5: 4417-22. PMID 724521 DOI: 10.1093/Nar/5.11.4417 |
0.749 |
|
| 1979 |
Neidle S, Sanderson MR, Subbiah A, Chattopadhyaya JB, Kuroda R, Reese CB. 9-beta-D-Arabinofuranosyl-8-n-butylaminoadenine, a C-8 substituted nucleoside in the anti conformation. Crystallographic and NMR studies. Biochimica Et Biophysica Acta. 565: 379-86. PMID 518888 DOI: 10.1016/0005-2787(79)90213-2 |
0.61 |
|
| 1979 |
Neidle S, Taylor GL. Nucleic acid binding drugs. Some conformational properties of the anti-cancer drug daunomycin and several of its derivatives:. Implications for DNA-binding Febs Letters. 107: 348-354. PMID 510544 DOI: 10.1016/0014-5793(79)80405-6 |
0.631 |
|
| 1979 |
Berman HM, Neidle S, Zimmer C, Thrum H. Netropsin, a DNA-binding oligopeptide structural and binding studies. Biochimica Et Biophysica Acta. 561: 124-31. PMID 420847 DOI: 10.1016/0005-2787(79)90496-9 |
0.393 |
|
| 1979 |
Berman HM, Stallings W, Carrell HL, Glusker JP, Neidle S, Taylor G, Achari A. Molecular and crystal structure of an intercalation complex: Proflavine-cytidylyl-(3?,5?)-guanosine Biopolymers. 18: 2405-2429. DOI: 10.1002/Bip.1979.360181004 |
0.632 |
|
| 1978 |
Neidle S, Taylor G. Nucleic acid binding drugs. Part IV. The crystal structure of the anti-cancer agent daunomycin. Biochimica Et Biophysica Acta. 479: 450-9. PMID 922013 DOI: 10.1016/0005-2787(77)90038-7 |
0.589 |
|
| 1978 |
Neidle S, Taylor GL, Robins AB. The structure of a platinum(II) complex of 1-(β-D-arabinofuranosyl)-cytosine Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry. 34: 1838-1841. DOI: 10.1107/S0567740878006792 |
0.525 |
|
| 1978 |
Malik NA, Sadler PJ, Neidle S, Taylor GL. X-Ray crystal structure of sodium bis(N-methylhydantoinato)gold(I) tetrahydrate; a linear, planar complex of pharmacological interest stabilised by two nitrogen ligands Journal of the Chemical Society, Chemical Communications. 711-712. DOI: 10.1039/C39780000711 |
0.588 |
|
| 1977 |
Neidle S, Achari A, Taylor GL, Berman HM, Carrell HL, Glusker JP, Stallings WC. Structure of a dinucleoside phosphate-drug complex as model for nucleic acid-drug interaction Nature. 269: 304-307. PMID 904684 DOI: 10.1038/269304A0 |
0.584 |
|
| 1974 |
Neidle S, Rogers D. The structure of 1-(16-hydroxy-phenoxymethyl)-3,4-dihydroisoquinoline hydrochloride monohydrate, a topical anti-viral agent Biochimica Et Biophysica Acta (Bba) - General Subjects. 338: 601-604. DOI: 10.1016/0304-4165(74)90323-7 |
0.464 |
|
| 1973 |
Hough E, Neidle S, Rogers D, Troughton PGH. The crystal structure of α-D-glucose monohydrate Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry. 29: 365-367. DOI: 10.1107/S0567740873002529 |
0.419 |
|
| 1973 |
Hursthouse MB, Neidle S. Crystal and molecular structure of (23R)-23-hydroxy-3α,5α-cycloergost-7-en-6-one Journal of the Chemical Society-Perkin Transactions 1. 781-786. DOI: 10.1039/P29730000781 |
0.417 |
|
| 1973 |
HURSTHOUSE MB, NEIDLE S. ChemInform Abstract: CRYSTAL AND MOLECULAR STRUCTURE OF (23R)-23-HYDROXY-3ALPHA,5ALPHA-CYCLOERGOST-7-EN-6-ONE Chemischer Informationsdienst. 4: no-no. DOI: 10.1002/Chin.197329102 |
0.369 |
|
| 1972 |
NEIDLE S, ROGERS D, HURSTHOUSE MB. ChemInform Abstract: KRISTALL- UND MOLEKULARSTRUKTUR VON VIRIDIN Chemischer Informationsdienst. 3: no-no. DOI: 10.1002/Chin.197230086 |
0.447 |
|
| 1971 |
Gabe EJ, Neidle S, Rogers D, Nordman CE. X-Ray determination of the molecular structure of a 3-o- chlorophenylisoxazoline derivative of pyrethrosin Journal of the Chemical Society D: Chemical Communications. 559-560. DOI: 10.1039/C29710000559 |
0.423 |
|
| 1970 |
NEIDLE S, ROGERS D. Assignment of Absolute Configuration from Anomalous Dispersion by Oxygen Atoms Nature. 225: 376-376. DOI: 10.1038/225376a0 |
0.371 |
|
| 1968 |
Neidle S, Rogers D, Hursthouse MB. The crystal and molecular structure of streptomycin oxime selenate. Tetrahedron Letters. 4725-8. PMID 5679310 DOI: 10.1016/S0040-4039(00)75942-9 |
0.53 |
|
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