| Year |
Citation |
Score |
| 2023 |
Chappard A, Leighton C, Saleeb RS, Jeacock K, Ball SR, Morris K, Kantelberg O, Lee JE, Zacco E, Pastore A, Sunde M, Clarke DJ, Downey P, Kunath T, Horrocks MH. Single-Molecule Two-Color Coincidence Detection of Unlabeled alpha-Synuclein Aggregates. Angewandte Chemie (Weinheim An Der Bergstrasse, Germany). 135: e202216771. PMID 38516037 DOI: 10.1002/ange.202216771 |
0.412 |
|
| 2023 |
Saleeb RS, Leighton C, Lee JE, O'Shaughnessy J, Jeacock K, Chappard A, Cumberland R, Zhao T, Ball SR, Sunde M, Clarke DJ, Piché K, McPhail JA, Louwrier A, Angers R, ... ... Horrocks MH, et al. Two-color coincidence single-molecule pulldown for the specific detection of disease-associated protein aggregates. Science Advances. 9: eadi7359. PMID 37967183 DOI: 10.1126/sciadv.adi7359 |
0.529 |
|
| 2023 |
Singh BP, Morris RJ, Kunath T, MacPhee CE, Horrocks MH. Lipid-induced polymorphic amyloid fibril formation by α-synuclein. Protein Science : a Publication of the Protein Society. e4736. PMID 37515406 DOI: 10.1002/pro.4736 |
0.373 |
|
| 2023 |
Colom-Cadena M, Davies C, Sirisi S, Lee JE, Simzer EM, Tzioras M, Querol-Vilaseca M, Sánchez-Aced É, Chang YY, Holt K, McGeachan RI, Rose J, Tulloch J, Wilkins L, Smith C, ... ... Horrocks MH, et al. Synaptic oligomeric tau in Alzheimer's disease - A potential culprit in the spread of tau pathology through the brain. Neuron. PMID 37192625 DOI: 10.1016/j.neuron.2023.04.020 |
0.378 |
|
| 2023 |
Chappard A, Leighton C, Saleeb RS, Jeacock K, Ball SR, Morris K, Kantelberg O, Lee JE, Zacco E, Pastore A, Sunde M, Clarke DJ, Downey P, Kunath T, Horrocks M. Single-molecule two-color coincidence detection of unlabeled alpha-synuclein aggregates. Angewandte Chemie (International Ed. in English). e202216771. PMID 36762870 DOI: 10.1002/anie.202216771 |
0.546 |
|
| 2022 |
Virdi GS, Choi ML, Evans JR, Yao Z, Athauda D, Strohbuecker S, Nirujogi RS, Wernick AI, Pelegrina-Hidalgo N, Leighton C, Saleeb RS, Kopach O, Alrashidi H, Melandri D, Perez-Lloret J, ... ... Horrocks MH, et al. Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neurons. Npj Parkinson's Disease. 8: 162. PMID 36424392 DOI: 10.1038/s41531-022-00423-7 |
0.345 |
|
| 2022 |
Choi ML, Chappard A, Singh BP, Maclachlan C, Rodrigues M, Fedotova EI, Berezhnov AV, De S, Peddie CJ, Athauda D, Virdi GS, Zhang W, Evans JR, Wernick AI, Zanjani ZS, ... ... Horrocks MH, et al. Author Correction: Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity. Nature Neuroscience. PMID 36261654 DOI: 10.1038/s41593-022-01206-2 |
0.76 |
|
| 2022 |
Choi ML, Chappard A, Singh BP, Maclachlan C, Rodrigues M, Fedotova EI, Berezhnov AV, De S, Peddie CJ, Athauda D, Virdi GS, Zhang W, Evans JR, Wernick AI, Zanjani ZS, ... ... Horrocks MH, et al. Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity. Nature Neuroscience. PMID 36042314 DOI: 10.1038/s41593-022-01140-3 |
0.786 |
|
| 2020 |
Angelova PR, Choi ML, Berezhnov AV, Horrocks MH, Hughes CD, De S, Rodrigues M, Yapom R, Little D, Dolt KS, Kunath T, Devine MJ, Gissen P, Shchepinov MS, Sylantyev S, et al. Correction: Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation. Cell Death and Differentiation. PMID 33041329 DOI: 10.1038/s41418-020-00634-6 |
0.754 |
|
| 2020 |
Angelova PR, Choi ML, Berezhnov AV, Horrocks MH, Hughes CD, De S, Rodrigues M, Yapom R, Little D, Dolt KS, Kunath T, Devine MJ, Gissen P, Shchepinov MS, Sylantyev S, et al. Correction: Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation. Cell Death and Differentiation. PMID 32409771 DOI: 10.1038/S41418-020-0552-X |
0.754 |
|
| 2020 |
Angelova PR, Choi ML, Berezhnov AV, Horrocks MH, Hughes CD, De S, Rodrigues M, Yapom R, Little D, Dolt KS, Kunath T, Devine MJ, Gissen P, Shchepinov MS, Sylantyev S, et al. Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation. Cell Death and Differentiation. PMID 32341450 DOI: 10.1038/S41418-020-0542-Z |
0.785 |
|
| 2020 |
Choi ML, Horrocks MH, Rodrigues M, De S, Tosatto L, Zhang W, Virdi G, Klenerman D, Abramov AY, Gandhi S. Tracking Oligomerization of Alpha-Synuclein Demonstrates Pivotal Role of Mitochondria in Seeding Biophysical Journal. 118: 217a. DOI: 10.1016/J.Bpj.2019.11.1289 |
0.734 |
|
| 2019 |
Pérez-Pi I, Evans DA, Horrocks MH, Pham NT, Dolt KS, Koszela J, Kunath T, Auer M. ASYN-CONA, a novel bead-based assay for detecting early stage α-synuclein aggregation. Analytical Chemistry. PMID 30964656 DOI: 10.1021/Acs.Analchem.8B03842 |
0.351 |
|
| 2018 |
Lee JE, Sang JC, Rodrigues M, Carr AR, Horrocks MH, De S, Bongiovanni MN, Flagmeier P, Dobson CM, Wales DJ, Lee SF, Klenerman D. Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale. Nano Letters. PMID 30380895 DOI: 10.1021/Acs.Nanolett.8B02916 |
0.803 |
|
| 2018 |
Taylor CG, Meisl G, Horrocks MH, Zetterberg H, Knowles TPJ, Klenerman D. Extrinsic Amyloid-Binding Dyes for the Detection of Individual Protein Aggregates in Solution. Analytical Chemistry. PMID 30059210 DOI: 10.1021/Acs.Analchem.8B02226 |
0.702 |
|
| 2018 |
Horrocks M, Whiten DR, Zuo Y, Calo L, Choi ML, De S, Flagmeier P, Wirthensohn DC, Kundel F, Lee SF, Dobson C, Gandhi S, Spillantini M, Klenerman D, Ranasinghe RT, et al. Nanoscopic characterization of individual endogenous protein aggregates in human neuronal cells. Chembiochem : a European Journal of Chemical Biology. PMID 30051958 DOI: 10.1002/Cbic.201800209 |
0.813 |
|
| 2018 |
Whiten DR, Cox D, Horrocks MH, Taylor CG, De S, Flagmeier P, Tosatto L, Kumita JR, Ecroyd H, Dobson CM, Klenerman D, Wilson MR. Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers. Cell Reports. 23: 3492-3500. PMID 29924993 DOI: 10.1016/J.Celrep.2018.05.074 |
0.786 |
|
| 2018 |
Ludtmann MHR, Angelova PR, Horrocks MH, Choi ML, Rodrigues M, Baev AY, Berezhnov AV, Yao Z, Little D, Banushi B, Al-Menhali AS, Ranasinghe RT, Whiten DR, Yapom R, Dolt KS, et al. α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease. Nature Communications. 9: 2293. PMID 29895861 DOI: 10.1038/S41467-018-04422-2 |
0.669 |
|
| 2018 |
Brown J, Horrocks MH. A sticky situation: aberrant protein-protein interactions in Parkinson's disease. Seminars in Cell & Developmental Biology. PMID 29738882 DOI: 10.1016/j.semcdb.2018.05.006 |
0.368 |
|
| 2018 |
Kundel F, Tosatto L, Whiten DR, Wirthensohn DC, Horrocks MH, Klenerman D. Shedding light on aberrant interactions: A review of modern tools for studying protein aggregates. The Febs Journal. PMID 29453901 DOI: 10.1111/Febs.14409 |
0.689 |
|
| 2018 |
Ranasinghe RT, Challand MR, Ganzinger KA, Lewis BW, Softley C, Schmied WH, Horrocks MH, Shivji N, Chin JW, Spencer J, Klenerman D. Detecting RNA base methylations in single cells by in situ hybridization. Nature Communications. 9: 655. PMID 29440632 DOI: 10.1038/S41467-017-02714-7 |
0.555 |
|
| 2018 |
Cox D, Whiten DR, Brown J, Horrocks MH, San Gil R, Dobson CM, Klenerman D, van Oijen AM, Ecroyd H. The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity. The Journal of Biological Chemistry. PMID 29382725 DOI: 10.1074/Jbc.M117.813865 |
0.676 |
|
| 2018 |
Kundel F, De S, Flagmeier P, Horrocks MH, Kjaergaard M, Shammas SL, Jackson SE, Dobson CM, Klenerman D. Hsp70 inhibits the nucleation and elongation of tau and sequesters tau aggregates with high affinity. Acs Chemical Biology. PMID 29300447 DOI: 10.1021/Acschembio.7B01039 |
0.78 |
|
| 2018 |
Angelova PR, Choi M, Horrocks MH, Klenerman D, Gandhi S, Abramov AY. Alpha-synuclein induces ferroptosis through generation of lipid peroxidation and calcium deregulation Free Radical Biology and Medicine. 120: S40. DOI: 10.1016/J.Freeradbiomed.2018.04.137 |
0.64 |
|
| 2018 |
Whiten DR, Zuo Y, Calo L, Choi M, De S, Flagmeier P, Wirthensohn DC, Kundel F, Ranasinghe RT, Sanchez SE, Athauda D, Lee SF, Dobson CM, Gandhi S, Spillantini M, ... ... Horrocks MH, et al. Cover Feature: Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells (ChemBioChem 19/2018) Chembiochem. 19: 2001-2001. DOI: 10.1002/Cbic.201800547 |
0.774 |
|
| 2017 |
Iljina M, Hong L, Horrocks MH, Ludtmann MH, Choi ML, Hughes CD, Ruggeri FS, Guilliams T, Buell AK, Lee JE, Gandhi S, Lee SF, Bryant CE, Vendruscolo M, Knowles TPJ, et al. Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species. Bmc Biology. 15: 57. PMID 28673288 DOI: 10.1186/S12915-017-0390-6 |
0.781 |
|
| 2017 |
Janeczek AA, Scarpa E, Horrocks MH, Tare RS, Rowland CA, Jenner D, Newman TA, Oreffo RO, Lee SF, Evans ND. PEGylated liposomes associate with Wnt3A protein and expand putative stem cells in human bone marrow populations. Nanomedicine (London, England). PMID 28351228 DOI: 10.2217/Nnm-2016-0386 |
0.568 |
|
| 2017 |
Raynes JK, Day L, Crepin P, Horrocks MH, Carver JA. Coaggregation of κ-Casein and β-Lactoglobulin Produces Morphologically Distinct Amyloid Fibrils. Small (Weinheim An Der Bergstrasse, Germany). PMID 28146312 DOI: 10.1002/smll.201603591 |
0.336 |
|
| 2017 |
Ludtmann M, Angelova P, Choi M, Horrocks M, Baev A, Little D, Devine M, Gissen P, Pavlov E, Klenerman D, Abramov A, Gandhi S. Direct Modulation of the Mitochondrial Permeability Transition Pore by Oligomeric Alpha-Synuclein Causes Toxicity in PD Biophysical Journal. 112: 440a. DOI: 10.1016/J.Bpj.2016.11.2351 |
0.668 |
|
| 2016 |
Bongiovanni MN, Godet J, Horrocks MH, Tosatto L, Carr AR, Wirthensohn DC, Ranasinghe RT, Lee JE, Ponjavic A, Fritz JV, Dobson CM, Klenerman D, Lee SF. Multi-dimensional super-resolution imaging enables surface hydrophobicity mapping. Nature Communications. 7: 13544. PMID 27929085 DOI: 10.1038/Ncomms13544 |
0.756 |
|
| 2016 |
Angelova PR, Ludtmann MH, Horrocks MH, Negoda A, Cremades N, Klenerman D, Dobson CM, Wood NW, Pavlov EV, Gandhi S, Abramov AY. Ca2+ is a key factor in α-synuclein-induced neurotoxicity. Development (Cambridge, England). 143: e1.1. PMID 27190039 DOI: 10.1242/dev.139345 |
0.582 |
|
| 2016 |
Jönsson P, Southcombe JH, Santos AM, Huo J, Fernandes RA, McColl J, Lever M, Evans EJ, Hudson A, Chang VT, Hanke T, Godkin A, Dunne PD, Horrocks MH, Palayret M, et al. Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions. Proceedings of the National Academy of Sciences of the United States of America. PMID 27114505 DOI: 10.1073/Pnas.1513918113 |
0.549 |
|
| 2016 |
Broadhead MJ, Horrocks MH, Zhu F, Muresan L, Benavides-Piccione R, DeFelipe J, Fricker D, Kopanitsa MV, Duncan RR, Klenerman D, Komiyama NH, Lee SF, Grant SG. PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits. Scientific Reports. 6: 24626. PMID 27109929 DOI: 10.1038/Srep24626 |
0.697 |
|
| 2016 |
Angelova PR, Ludtmann MH, Horrocks MH, Negoda A, Cremades N, Klenerman D, Dobson CM, Wood NW, Pavlov EV, Gandhi S, Abramov AY. Calcium is a key factor in α-synuclein induced neurotoxicity. Journal of Cell Science. PMID 26989132 DOI: 10.1242/Jcs.180737 |
0.649 |
|
| 2016 |
Iljina M, Garcia GA, Horrocks MH, Tosatto L, Choi ML, Ganzinger KA, Abramov AY, Gandhi S, Wood NW, Cremades N, Dobson CM, Knowles TP, Klenerman D. Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading. Proceedings of the National Academy of Sciences of the United States of America. PMID 26884195 DOI: 10.1073/Pnas.1524128113 |
0.691 |
|
| 2016 |
Horrocks MH, Lee SF, Gandhi S, Magdalinou NK, Chen SW, Devine MJ, Tosatto L, Kjaergaard M, Beckwith JS, Zetterberg H, Iljina M, Cremades N, Dobson CM, Wood NW, Klenerman D. Single-molecule imaging of individual amyloid protein aggregates in human biofluids. Acs Chemical Neuroscience. PMID 26800462 DOI: 10.1021/Acschemneuro.5B00324 |
0.788 |
|
| 2015 |
Tosatto L, Horrocks MH, Dear AJ, Knowles TP, Dalla Serra M, Cremades N, Dobson CM, Klenerman D. Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants. Scientific Reports. 5: 16696. PMID 26582456 DOI: 10.1038/Srep16696 |
0.663 |
|
| 2015 |
Deas E, Cremades N, Angelova PR, Ludtmann M, Yao Z, Chen S, Horrocks M, Banushi B, Little D, Devine M, Gissen P, Klenerman D, Dobson C, Wood N, Gandhi S, et al. Alpha-synuclein oligomers interact with metal ions to induce oxidative stress and neuronal death in Parkinson's disease. Antioxidants & Redox Signaling. PMID 26564470 DOI: 10.1089/Ars.2015.6343 |
0.661 |
|
| 2015 |
Horrocks MH, Tosatto L, Dear AJ, Garcia GA, Iljina M, Cremades N, Dalla Serra M, Knowles TP, Dobson CM, Klenerman D. Fast Flow Microfluidics and Single-Molecule Fluorescence for the Rapid Characterization of α-Synuclein Oligomers. Analytical Chemistry. 87: 8818-26. PMID 26258431 DOI: 10.1021/Acs.Analchem.5B01811 |
0.671 |
|
| 2015 |
Reeve AK, Ludtmann MH, Angelova PR, Simcox EM, Horrocks MH, Klenerman D, Gandhi S, Turnbull DM, Abramov AY. Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons. Cell Death & Disease. 6: e1820. PMID 26181201 DOI: 10.1038/Cddis.2015.166 |
0.648 |
|
| 2015 |
Shammas SL, Garcia GA, Kumar S, Kjaergaard M, Horrocks MH, Shivji N, Mandelkow E, Knowles TP, Mandelkow E, Klenerman D. A mechanistic model of tau amyloid aggregation based on direct observation of oligomers. Nature Communications. 6: 7025. PMID 25926130 DOI: 10.1038/Ncomms8025 |
0.666 |
|
| 2015 |
Angelova PR, Horrocks MH, Klenerman D, Gandhi S, Abramov AY, Shchepinov MS. Lipid peroxidation is essential for α-synuclein-induced cell death. Journal of Neurochemistry. 133: 582-9. PMID 25580849 DOI: 10.1111/Jnc.13024 |
0.649 |
|
| 2014 |
Murphy RR, Danezis G, Horrocks MH, Jackson SE, Klenerman D. Bayesian inference of accurate population sizes and FRET efficiencies from single diffusing biomolecules. Analytical Chemistry. 86: 8603-12. PMID 25105347 DOI: 10.1021/Ac501188R |
0.555 |
|
| 2014 |
Horrocks MH, Palayret M, Klenerman D, Lee SF. The changing point-spread function: single-molecule-based super-resolution imaging. Histochemistry and Cell Biology. 141: 577-85. PMID 24509806 DOI: 10.1007/S00418-014-1186-1 |
0.702 |
|
| 2014 |
Tosatto L, Horrocks MH, Nunilo C, Guilliams T, Serra MD, Klenerman D. Single Molecule FRET Characterization of Oligomers from Alpha-Synuclein Early Onset Parkinson's Disease Mutants Biophysical Journal. 106: 269a. DOI: 10.1016/J.Bpj.2013.11.1575 |
0.654 |
|
| 2014 |
Horrocks MH, Lee SF, Gandhi S, Iljina M, Tosatto L, Dobson CM, Klenerman D. Single-Molecule Characterisation of Alpha-Synuclein Oligomers Biophysical Journal. 106: 268a. DOI: 10.1016/J.Bpj.2013.11.1573 |
0.784 |
|
| 2013 |
Horrocks MH, Rajah L, Jönsson P, Kjaergaard M, Vendruscolo M, Knowles TP, Klenerman D. Single-molecule measurements of transient biomolecular complexes through microfluidic dilution. Analytical Chemistry. 85: 6855-9. PMID 23782428 DOI: 10.1021/Ac4010875 |
0.567 |
|
| 2013 |
Flint JA, Narayan P, Horrocks MH, Shammas SL, Kjaergaard M, Klenerman D. Single Molecule Fluorescence Studies of Amyloid Beta 1-42 Aggregation Biophysical Journal. 104: 359a-360a. DOI: 10.1016/J.Bpj.2012.11.1997 |
0.671 |
|
| 2012 |
Ye Y, Blaser G, Horrocks MH, Ruedas-Rama MJ, Ibrahim S, Zhukov AA, Orte A, Klenerman D, Jackson SE, Komander D. Ubiquitin chain conformation regulates recognition and activity of interacting proteins. Nature. 492: 266-70. PMID 23201676 DOI: 10.1038/Nature11722 |
0.589 |
|
| 2012 |
Horrocks MH, Li H, Shim JU, Ranasinghe RT, Clarke RW, Huck WT, Abell C, Klenerman D. Single molecule fluorescence under conditions of fast flow. Analytical Chemistry. 84: 179-85. PMID 22147688 DOI: 10.1021/Ac202313D |
0.574 |
|
| 2012 |
Horrocks MH, Cremades N, Tosatto L, Guilliams T, De Genst E, Shim J, Dobson CM, Klenerman D. Investigating the Factors Affecting the Aggregation of Alpha-Synuclein using Single Molecule Fluorescence and Fast Flow Microfluidics Biophysical Journal. 102: 255a. DOI: 10.1016/J.Bpj.2011.11.1407 |
0.668 |
|
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