| Year |
Citation |
Score |
| 2022 |
Ly CY, Pfannenstiel J, Pant A, Yang Z, Fehr AR, Rodzkin MS, Davido DJ. Inhibitors of One or More Cellular Aurora Kinases Impair the Replication of Herpes Simplex Virus 1 and Other DNA and RNA Viruses with Diverse Genomes and Life Cycles. Microbiology Spectrum. e0194322. PMID 36537798 DOI: 10.1128/spectrum.01943-22 |
0.414 |
|
| 2022 |
Parthasarathy S, Fehr AR. PARP14: A key ADP-ribosylating protein in host-virus interactions? Plos Pathogens. 18: e1010535. PMID 35679255 DOI: 10.1371/journal.ppat.1010535 |
0.392 |
|
| 2022 |
Roy A, Alhammad YM, McDonald P, Johnson DK, Zhuo J, Wazir S, Ferraris D, Lehtiö L, Leung AKL, Fehr AR. Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening. Antiviral Research. 105344. PMID 35598780 DOI: 10.1016/j.antiviral.2022.105344 |
0.383 |
|
| 2022 |
Comar CE, Otter CJ, Pfannenstiel J, Doerger E, Renner DM, Tan LH, Perlman S, Cohen NA, Fehr AR, Weiss SR. MERS-CoV endoribonuclease and accessory proteins jointly evade host innate immunity during infection of lung and nasal epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 119: e2123208119. PMID 35594398 DOI: 10.1073/pnas.2123208119 |
0.601 |
|
| 2022 |
Roy A, Alhammad YM, McDonald P, Johnson DK, Zhuo J, Wazir S, Ferraris D, Lehtiö L, Leung AKL, Fehr AR. Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening. Biorxiv : the Preprint Server For Biology. PMID 35262075 DOI: 10.1101/2022.03.01.482536 |
0.386 |
|
| 2022 |
Leung AKL, Griffin DE, Bosch J, Fehr AR. The Conserved Macrodomain Is a Potential Therapeutic Target for Coronaviruses and Alphaviruses. Pathogens (Basel, Switzerland). 11. PMID 35056042 DOI: 10.3390/pathogens11010094 |
0.429 |
|
| 2021 |
Comar CE, Otter CJ, Pfannenstiel J, Doerger E, Renner DM, Tan LH, Perlman S, Cohen NA, Fehr AR, Weiss SR. MERS-CoV endoribonuclease and accessory proteins jointly evade host innate immunity during infection of lung and nasal epithelial cells. Biorxiv : the Preprint Server For Biology. PMID 34981054 DOI: 10.1101/2021.12.20.473564 |
0.65 |
|
| 2021 |
Dasovich M, Zhuo J, Goodman JA, Thomas A, McPherson RL, Jayabalan AK, Busa VF, Cheng SJ, Murphy BA, Redinger KR, Alhammad YMO, Fehr AR, Tsukamoto T, Slusher BS, Bosch J, et al. High-Throughput Activity Assay for Screening Inhibitors of the SARS-CoV-2 Mac1 Macrodomain. Acs Chemical Biology. PMID 34904435 DOI: 10.1021/acschembio.1c00721 |
0.326 |
|
| 2021 |
Lüscher B, Ahel I, Altmeyer M, Ashworth A, Bai P, Chang P, Cohen M, Corda D, Dantzer F, Daugherty MD, Dawson TM, Dawson VL, Deindl S, Fehr AR, Feijs KLH, et al. ADP-ribosyltransferases, an update on function and nomenclature. The Febs Journal. PMID 34323016 DOI: 10.1111/febs.16142 |
0.376 |
|
| 2021 |
Voth LS, O'Connor JJ, Kerr CM, Doerger E, Schwarting N, Sperstad P, Johnson DK, Fehr AR. Unique mutations in the MHV macrodomain differentially attenuate virus replication, indicating multiple roles for the macrodomain in coronavirus replication. Journal of Virology. PMID 34011547 DOI: 10.1128/JVI.00766-21 |
0.758 |
|
| 2021 |
Voth LS, O'Connor JJ, Kerr CM, Doerger E, Schwarting N, Sperstad P, Johnson DK, Fehr AR. An MHV macrodomain mutant predicted to lack ADP-ribose binding activity is severely attenuated, indicating multiple roles for the macrodomain in coronavirus replication. Biorxiv : the Preprint Server For Biology. PMID 33821264 DOI: 10.1101/2021.03.30.437796 |
0.749 |
|
| 2020 |
Alhammad YMO, Kashipathy MM, Roy A, Gagné JP, McDonald P, Gao P, Nonfoux L, Battaile KP, Johnson DK, Holmstrom ED, Poirier GG, Lovell S, Fehr AR. The SARS-CoV-2 conserved macrodomain is a mono-ADP-ribosylhydrolase. Journal of Virology. PMID 33158944 DOI: 10.1128/JVI.01969-20 |
0.46 |
|
| 2020 |
Ghosh S, Dellibovi-Ragheb TA, Kerviel A, Pak E, Qiu Q, Fisher M, Takvorian PM, Bleck C, Hsu VW, Fehr AR, Perlman S, Achar SR, Straus MR, Whittaker GR, de Haan CAM, et al. β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway. Cell. PMID 33157038 DOI: 10.1016/j.cell.2020.10.039 |
0.51 |
|
| 2020 |
Heer CD, Sanderson DJ, Voth LS, Alhammad YMO, Schmidt MS, Trammell SAJ, Perlman S, Cohen MS, Fehr AR, Brenner C. Coronavirus infection and PARP expression dysregulate the NAD Metabolome: an actionable component of innate immunity. The Journal of Biological Chemistry. PMID 33051211 DOI: 10.1074/jbc.RA120.015138 |
0.629 |
|
| 2020 |
Alhammad YMO, Kashipathy MM, Roy A, Johnson DK, McDonald P, Battaile KP, Gao P, Lovell S, Fehr AR. The SARS-CoV-2 conserved macrodomain is a highly efficient ADP-ribosylhydrolase enzyme. Biorxiv : the Preprint Server For Biology. PMID 32511412 DOI: 10.1101/2020.05.11.089375 |
0.448 |
|
| 2020 |
Heer CD, Sanderson DJ, Alhammad YMO, Schmidt MS, Trammell SAJ, Perlman S, Cohen MS, Fehr AR, Brenner C. Coronavirus and PARP expression dysregulate the NAD Metabolome: a potentially actionable component of innate immunity. Biorxiv : the Preprint Server For Biology. PMID 32511303 DOI: 10.1101/2020.04.17.047480 |
0.563 |
|
| 2020 |
Alhammad YMO, Fehr AR. The Viral Macrodomain Counters Host Antiviral ADP-Ribosylation. Viruses. 12. PMID 32244383 DOI: 10.3390/v12040384 |
0.478 |
|
| 2020 |
Fehr AR, Singh SA, Kerr CM, Mukai S, Higashi H, Aikawa M. The impact of PARPs and ADP-ribosylation on inflammation and host-pathogen interactions. Genes & Development. PMID 32029454 DOI: 10.1101/gad.334425.119 |
0.668 |
|
| 2019 |
Grunewald ME, Shaban MG, Mackin SR, Fehr AR, Perlman S. Murine coronavirus infection activates AhR in an IDO1-independent manner contributing to cytokine modulation and pro-viral TiPARP expression. Journal of Virology. PMID 31694960 DOI: 10.1128/Jvi.01743-19 |
0.66 |
|
| 2019 |
Channappanavar R, Fehr AR, Zheng J, Wohlford-Lenane C, Abrahante JE, Mack M, Sompallae R, McCray PB, Meyerholz DK, Perlman S. IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes. The Journal of Clinical Investigation. 130. PMID 31355779 DOI: 10.1172/Jci126363 |
0.632 |
|
| 2019 |
Grunewald ME, Chen Y, Kuny C, Maejima T, Lease R, Ferraris D, Aikawa M, Sullivan CS, Perlman S, Fehr AR. The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression. Plos Pathogens. 15: e1007756. PMID 31095648 DOI: 10.1371/Journal.Ppat.1007756 |
0.677 |
|
| 2018 |
Athmer J, Fehr AR, Grunewald ME, Qu W, Wheeler DL, Graepel KW, Channappanavar R, Sekine A, Aldabeeb DS, Gale M, Denison MR, Perlman S. Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses. Mbio. 9. PMID 29717007 DOI: 10.1128/Mbio.00272-18 |
0.558 |
|
| 2018 |
Galasiti Kankanamalage AC, Kim Y, Damalanka VC, Rathnayake AD, Fehr AR, Mehzabeen N, Battaile KP, Lovell S, Lushington GH, Perlman S, Chang KO, Groutas WC. Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element. European Journal of Medicinal Chemistry. 150: 334-346. PMID 29544147 DOI: 10.1016/J.Ejmech.2018.03.004 |
0.487 |
|
| 2018 |
Canton J, Fehr AR, Fernandez-Delgado R, Gutierrez-Alvarez FJ, Sanchez-Aparicio MT, García-Sastre A, Perlman S, Enjuanes L, Sola I. MERS-CoV 4b protein interferes with the NF-κB-dependent innate immune response during infection. Plos Pathogens. 14: e1006838. PMID 29370303 DOI: 10.1371/Journal.Ppat.1006838 |
0.523 |
|
| 2017 |
Fehr AR, Jankevicius G, Ahel I, Perlman S. Viral Macrodomains: Unique Mediators of Viral Replication and Pathogenesis. Trends in Microbiology. PMID 29268982 DOI: 10.1016/J.Tim.2017.11.011 |
0.646 |
|
| 2017 |
Grunewald ME, Fehr AR, Athmer J, Perlman S. The coronavirus nucleocapsid protein is ADP-ribosylated. Virology. PMID 29199039 DOI: 10.1016/J.Virol.2017.11.020 |
0.611 |
|
| 2017 |
Vijay R, Fehr AR, Janowski AM, Athmer J, Wheeler DL, Grunewald M, Sompallae R, Kurup SP, Meyerholz DK, Sutterwala FS, Narumiya S, Perlman S. Virus-induced inflammasome activation is suppressed by prostaglandin D2/DP1 signaling. Proceedings of the National Academy of Sciences of the United States of America. PMID 28630327 DOI: 10.1073/Pnas.1704099114 |
0.501 |
|
| 2017 |
Athmer J, Fehr AR, Grunewald M, Smith EC, Denison MR, Perlman S. In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated Proteins. Mbio. 8. PMID 28143984 DOI: 10.1128/Mbio.02320-16 |
0.597 |
|
| 2016 |
Fehr AR, Channappanavar R, Jankevicius G, Fett C, Zhao J, Athmer J, Meyerholz DK, Ahel I, Perlman S. The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection. Mbio. 7. PMID 27965448 DOI: 10.1128/Mbio.01721-16 |
0.684 |
|
| 2016 |
Park JE, Li K, Barlan A, Fehr AR, Perlman S, McCray PB, Gallagher T. Proteolytic processing of Middle East respiratory syndrome coronavirus spikes expands virus tropism. Proceedings of the National Academy of Sciences of the United States of America. 113: 12262-12267. PMID 27791014 DOI: 10.1073/Pnas.1608147113 |
0.606 |
|
| 2016 |
Fehr AR, Channappanavar R, Perlman S. Middle East Respiratory Syndrome: Emergence of a Pathogenic Human Coronavirus. Annual Review of Medicine. PMID 27576010 DOI: 10.1146/Annurev-Med-051215-031152 |
0.552 |
|
| 2016 |
Channappanavar R, Fehr AR, Vijay R, Mack M, Zhao J, Meyerholz DK, Perlman S. Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice. Cell Host & Microbe. 19: 181-93. PMID 26867177 DOI: 10.1016/J.Chom.2016.01.007 |
0.595 |
|
| 2015 |
Fehr AR, Perlman S. Coronaviruses: an overview of their replication and pathogenesis. Methods in Molecular Biology (Clifton, N.J.). 1282: 1-23. PMID 25720466 DOI: 10.1007/978-1-4939-2438-7_1 |
0.545 |
|
| 2015 |
Fehr AR, Athmer J, Channappanavar R, Phillips JM, Meyerholz DK, Perlman S. The nsp3 macrodomain promotes virulence in mice with coronavirus-induced encephalitis. Journal of Virology. 89: 1523-36. PMID 25428866 DOI: 10.1128/Jvi.02596-14 |
0.651 |
|
| 2014 |
Lauron EJ, Yu D, Fehr AR, Hertel L. Human cytomegalovirus infection of langerhans-type dendritic cells does not require the presence of the gH/gL/UL128-131A complex and is blocked after nuclear deposition of viral genomes in immature cells. Journal of Virology. 88: 403-16. PMID 24155395 DOI: 10.1128/JVI.03062-13 |
0.601 |
|
| 2013 |
Caffarelli N, Fehr AR, Yu D. Cyclin A degradation by primate cytomegalovirus protein pUL21a counters its innate restriction of virus replication. Plos Pathogens. 9: e1003825. PMID 24385906 DOI: 10.1371/journal.ppat.1003825 |
0.643 |
|
| 2013 |
Fehr AR, Yu D. Control the host cell cycle: viral regulation of the anaphase-promoting complex. Journal of Virology. 87: 8818-25. PMID 23760246 DOI: 10.1128/JVI.00088-13 |
0.647 |
|
| 2013 |
Chapa TJ, Johnson LS, Affolter C, Valentine MC, Fehr AR, Yokoyama WM, Yu D. Murine cytomegalovirus protein pM79 is a key regulator for viral late transcription. Journal of Virology. 87: 9135-47. PMID 23760242 DOI: 10.1128/Jvi.00688-13 |
0.61 |
|
| 2012 |
Fehr AR, Gualberto NC, Savaryn JP, Terhune SS, Yu D. Proteasome-dependent disruption of the E3 ubiquitin ligase anaphase-promoting complex by HCMV protein pUL21a. Plos Pathogens. 8: e1002789. PMID 22792066 DOI: 10.1371/Journal.Ppat.1002789 |
0.672 |
|
| 2011 |
Perng YC, Qian Z, Fehr AR, Xuan B, Yu D. The human cytomegalovirus gene UL79 is required for the accumulation of late viral transcripts. Journal of Virology. 85: 4841-52. PMID 21367901 DOI: 10.1128/JVI.02344-10 |
0.653 |
|
| 2011 |
Fehr AR, Yu D. Human cytomegalovirus early protein pUL21a promotes efficient viral DNA synthesis and the late accumulation of immediate-early transcripts. Journal of Virology. 85: 663-74. PMID 21047969 DOI: 10.1128/JVI.01599-10 |
0.634 |
|
| 2010 |
Fehr AR, Yu D. Human cytomegalovirus gene UL21a encodes a short-lived cytoplasmic protein and facilitates virus replication in fibroblasts. Journal of Virology. 84: 291-302. PMID 19846516 DOI: 10.1128/JVI.01116-09 |
0.672 |
|
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