| Year |
Citation |
Score |
| 2022 |
Mohamed H, Baryar U, Bashiri A, Selvaratnam R, VanSchouwen B, Melacini G. Identification of Core Allosteric Sites through Temperature- and Nucleus-Invariant Chemical Shift Covariance. Biophysical Journal. PMID 35538664 DOI: 10.1016/j.bpj.2022.05.004 |
0.686 |
|
| 2021 |
McNicholl ET, Das R, SilDas S, Byun JA, Akimoto M, Jafari N, Melacini G. Backbone resonance assignment of the cAMP-binding domains of the protein kinase A regulatory subunit Iα. Biomolecular Nmr Assignments. PMID 34118011 DOI: 10.1007/s12104-021-10033-8 |
0.796 |
|
| 2021 |
Jafari N, Del Rio J, Akimoto M, Byun JA, Boulton S, Moleschi K, Alsayyed Y, Swanson P, Huang J, Martinez Pomier K, Lee C, Wu J, Taylor SS, Melacini G. Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34006641 DOI: 10.1073/pnas.2024716118 |
0.774 |
|
| 2020 |
Byun JA, VanSchouwen B, Akimoto M, Melacini G. Allosteric inhibition explained through conformational ensembles sampling distinct "mixed" states. Computational and Structural Biotechnology Journal. 18: 3803-3818. PMID 33335680 DOI: 10.1016/j.csbj.2020.10.026 |
0.325 |
|
| 2020 |
Shao H, Boulton S, Olivieri C, Mohamed H, Akimoto M, Subrahmanian MV, Veglia G, Markley JL, Melacini G, Lee W. CHESPA/CHESCA-SPARKY: automated NMR data analysis plugins for SPARKY to map protein allostery. Bioinformatics (Oxford, England). PMID 32926121 DOI: 10.1093/Bioinformatics/Btaa781 |
0.319 |
|
| 2020 |
Boulton S, Van K, VanSchouwen B, Augustine J, Akimoto M, Melacini G. Allosteric Mechanisms of Nonadditive Substituent Contributions to Protein-Ligand Binding. Biophysical Journal. PMID 32882185 DOI: 10.1016/J.Bpj.2020.07.038 |
0.436 |
|
| 2020 |
Martinez Pomier K, Ahmed R, Melacini G. Catechins as Tools to Understand the Molecular Basis of Neurodegeneration. Molecules (Basel, Switzerland). 25. PMID 32781559 DOI: 10.3390/Molecules25163571 |
0.353 |
|
| 2020 |
García-Viñuales S, Ahmed R, Sciacca MFM, Lanza V, Giuffrida ML, Zimbone S, Romanucci V, Zarrelli A, Bongiorno C, Spinella N, Galati C, Di Fabio G, Melacini G, Milardi D. Trehalose conjugates of silybin as prodrugs for targeting toxic Aβ aggregates. Acs Chemical Neuroscience. PMID 32687307 DOI: 10.1021/Acschemneuro.0C00232 |
0.371 |
|
| 2020 |
Byun JA, Akimoto M, VanSchouwen B, Lazarou TS, Taylor SS, Melacini G. Allosteric pluripotency as revealed by protein kinase A. Science Advances. 6: eabb1250. PMID 32596469 DOI: 10.1126/Sciadv.Abb1250 |
0.402 |
|
| 2020 |
Akimoto M, Yu T, Moleschi K, Van K, Anand GS, Melacini G. An NMR based phosphodiesterase assay. Chemical Communications (Cambridge, England). PMID 32555789 DOI: 10.1039/D0Cc01673J |
0.33 |
|
| 2020 |
Ahmed R, Huang J, Weber DK, Gopinath T, Veglia G, Akimoto M, Khondker A, Rheinstadter MC, Huynh V, Wylie RG, Bozelli JC, Epand RM, Melacini G. Molecular Mechanism for the Suppression of Alpha Synuclein Membrane Toxicity by an Unconventional Extracellular Chaperone. Journal of the American Chemical Society. PMID 32383602 DOI: 10.1021/Jacs.0C01894 |
0.336 |
|
| 2020 |
Byun JA, Van K, Huang J, Henning P, Franz E, Akimoto M, Herberg FW, Kim C, Melacini G. Mechanism of allosteric inhibition in the cGMP-dependent protein kinase. The Journal of Biological Chemistry. PMID 32317283 DOI: 10.1074/Jbc.Ra120.013070 |
0.391 |
|
| 2020 |
Shao H, Mohamed H, Boulton S, Huang J, Wang P, Chen H, Zhou J, Luchowska-Stańska U, Jentsch NG, Armstrong AL, Magolan J, Yarwood S, Melacini G. Mechanism of Action of an EPAC1-Selective Competitive Partial Agonist. Journal of Medicinal Chemistry. PMID 32297742 DOI: 10.1021/Acs.Jmedchem.9B02151 |
0.405 |
|
| 2020 |
Almawi AW, Langlois-Lemay L, Boulton S, Rodríguez González J, Melacini G, D'Amours D, Guarné A. Distinct surfaces on Cdc5/PLK Polo-box domain orchestrate combinatorial substrate recognition during cell division. Scientific Reports. 10: 3379. PMID 32099015 DOI: 10.1038/S41598-020-60344-4 |
0.4 |
|
| 2020 |
Byun O, Van K, Henning P, Herberg FW, Melacini G. Mechanism of Allosteric Inhibition of Plasmodium falciparum CGMP-Dependent Protein Kinase Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.2870 |
0.314 |
|
| 2019 |
Ahmed A, Boulton S, Shao H, Akimoto M, Natarajan A, Cheng X, Melacini G. Recent Advances in EPAC-Targeted Therapies: A Biophysical Perspective. Cells. 8. PMID 31752286 DOI: 10.3390/Cells8111462 |
0.363 |
|
| 2019 |
Ahmed R, Akcan M, Khondker A, Rheinstädter MC, Bozelli JC, Epand RM, Huynh V, Wylie RG, Boulton S, Huang J, Verschoor CP, Melacini G. Atomic resolution map of the soluble amyloid beta assembly toxic surfaces. Chemical Science. 10: 6072-6082. PMID 31360412 DOI: 10.1039/C9Sc01331H |
0.356 |
|
| 2019 |
Boulton S, Selvaratnam R, Ahmed R, Van K, Cheng X, Melacini G. Mechanisms of Specific versus Nonspecific Interactions of Aggregation-Prone Inhibitors and Attenuators. Journal of Medicinal Chemistry. PMID 31074269 DOI: 10.1021/Acs.Jmedchem.9B00258 |
0.724 |
|
| 2018 |
Boulton S, Selvaratnam R, Blondeau JP, Lezoualc'h F, Melacini G. Mechanism of Selective Enzyme Inhibition through Uncompetitive Regulation of an Allosteric Agonist. Journal of the American Chemical Society. PMID 30016089 DOI: 10.1021/Jacs.8B05044 |
0.734 |
|
| 2018 |
Byun JA, Melacini G. NMR Methods to Dissect the Molecular Mechanisms of Disease-Related Mutations (DRMs): Understanding How DRMs Remodel Functional Free Energy Landscapes. Methods (San Diego, Calif.). PMID 29857190 DOI: 10.1016/J.Ymeth.2018.05.018 |
0.377 |
|
| 2018 |
Ahmed R, Melacini G. A solution NMR toolset to probe the molecular mechanisms of amyloid inhibitors. Chemical Communications (Cambridge, England). PMID 29658548 DOI: 10.1039/C8Cc01380B |
0.392 |
|
| 2018 |
Baid K, Nellimarla S, Huynh A, Boulton S, Guarné A, Melacini G, Collins SE, Mossman KL. Direct binding and internalization of diverse extracellular nucleic acid species through the collagenous domain of class A scavenger receptors. Immunology and Cell Biology. PMID 29617041 DOI: 10.1111/Imcb.12052 |
0.34 |
|
| 2018 |
VanSchouwen B, Melacini G. Role of Dimers in the cAMP-Dependent Activation of Hyperpolarization-Activated Cyclic-Nucleotide-Modulated (HCN) Ion Channels. The Journal of Physical Chemistry. B. PMID 29461059 DOI: 10.1021/Acs.Jpcb.7B10125 |
0.391 |
|
| 2018 |
Akimoto M, VanSchouwen B, Melacini G. The Structure of the Apo cAMP-Binding Domain of HCN4: A Stepping Stone towards Understanding the cAMP-Dependent Modulation of the Hyperpolarization-Activated Cyclic-Nucleotide-Gated (HCN) Ion Channels. The Febs Journal. PMID 29444387 DOI: 10.1111/Febs.14408 |
0.393 |
|
| 2018 |
Nguyen Y, Boulton S, McNicholl ET, Akimoto M, Harvey H, Aidoo F, Melacini G, Burrows LL. A highly dynamic loop of the Pseudomonas aeruginosa PA14 type IV pilin is essential for pilus assembly. Acs Infectious Diseases. PMID 29342354 DOI: 10.1021/Acsinfecdis.7B00229 |
0.353 |
|
| 2018 |
Boulton S, Selvaratnam R, Ahmed R, Melacini G. Implementation of the NMR CHEmical Shift Covariance Analysis (CHESCA): A Chemical Biologist's Approach to Allostery. Methods in Molecular Biology (Clifton, N.J.). 1688: 391-405. PMID 29151219 DOI: 10.1007/978-1-4939-7386-6_18 |
0.703 |
|
| 2017 |
VanSchouwen B, Ahmed R, Milojevic J, Melacini G. Functional dynamics in cyclic nucleotide signaling and amyloid inhibition. Biochimica Et Biophysica Acta. PMID 28911813 DOI: 10.1016/J.Bbapap.2017.09.005 |
0.793 |
|
| 2017 |
Ahmed R, VanSchouwen B, Jafari N, Ni X, Ortega J, Melacini G. Molecular Mechanism for the (-)-Epigallocatechin Gallate-Induced Toxic to Nontoxic Remodeling of Aβ Oligomers. Journal of the American Chemical Society. PMID 28841302 DOI: 10.1021/Jacs.7B05012 |
0.802 |
|
| 2017 |
Algamal M, Ahmed R, Jafari N, Ahsan B, Ortega J, Melacini G. Atomic-Resolution Map of the Interactions between an Amyloid Inhibitor Protein and Amyloid Beta (Aβ) Peptides in the Monomer and Protofibril States. The Journal of Biological Chemistry. PMID 28798235 DOI: 10.1074/Jbc.M117.792853 |
0.801 |
|
| 2017 |
VanSchouwen B, Melacini G. Regulation of HCN Ion Channels by Non-canonical Cyclic Nucleotides. Handbook of Experimental Pharmacology. PMID 28181007 DOI: 10.1007/164_2016_5006 |
0.304 |
|
| 2017 |
Boulton S, Akimoto M, Akbarizadeh S, Melacini G. Free Energy Landscape Remodeling of the Cardiac Pacemaker Channel Explains the Molecular Basis of Familial Sinus Bradycardia. The Journal of Biological Chemistry. PMID 28174302 DOI: 10.1074/Jbc.M116.773697 |
0.326 |
|
| 2016 |
Campbell JC, VanSchouwen B, Lorenz R, Sankaran B, Herberg FW, Melacini G, Kim C. Crystal structure of PKG Iβ CNB-B:Rp-cGMPS complex reveals an apo-like, inactive conformation. Febs Letters. PMID 27914169 DOI: 10.1002/1873-3468.12505 |
0.414 |
|
| 2016 |
VanSchouwen B, Melacini G. Structural Basis of Tonic Inhibition by Dimers of Dimers in Hyperpolarization-Activated Cyclic-Nucleotide-Modulated (HCN) Ion Channels. The Journal of Physical Chemistry. B. PMID 27690448 DOI: 10.1021/Acs.Jpcb.6B07735 |
0.39 |
|
| 2016 |
Almawi AW, Matthews LA, Larasati, Myrox P, Boulton S, Lai C, Moraes T, Melacini G, Ghirlando R, Duncker BP, Guarné A. 'AND' logic gates at work: Crystal structure of Rad53 bound to Dbf4 and Cdc7. Scientific Reports. 6: 34237. PMID 27681475 DOI: 10.1038/Srep34237 |
0.42 |
|
| 2016 |
VanSchouwen B, Melacini G. Cracking the allosteric code of NMR chemical shifts. Proceedings of the National Academy of Sciences of the United States of America. 113: 9407-9. PMID 27512035 DOI: 10.1073/Pnas.1611068113 |
0.387 |
|
| 2016 |
Jafari N, Ahmed R, Gloyd M, Bloomfield J, Britz-McKibbin P, Melacini G. Allosteric Sensing of Fatty Acid Binding by NMR: Application to Human Serum Albumin. Journal of Medicinal Chemistry. PMID 27429126 DOI: 10.1021/Acs.Jmedchem.6B00410 |
0.775 |
|
| 2016 |
Boulton S, Melacini G. Advances in NMR Methods To Map Allosteric Sites: From Models to Translation. Chemical Reviews. PMID 27111288 DOI: 10.1021/Acs.Chemrev.5B00718 |
0.383 |
|
| 2015 |
Byun JA, Melacini G. Disordered Regions Flanking Ordered Domains Modulate Signaling Transduction. Biophysical Journal. 109: 2447-8. PMID 26682801 DOI: 10.1016/J.Bpj.2015.10.030 |
0.324 |
|
| 2015 |
Akimoto M, McNicholl ET, Ramkissoon A, Moleschi K, Taylor SS, Melacini G. Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα. Plos Biology. 13: e1002305. PMID 26618408 DOI: 10.1371/Journal.Pbio.1002305 |
0.463 |
|
| 2015 |
VanSchouwen B, Selvaratnam R, Giri R, Lorenz R, Herberg FW, Kim C, Melacini G. Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG). The Journal of Biological Chemistry. PMID 26370085 DOI: 10.1074/Jbc.M115.685305 |
0.724 |
|
| 2015 |
Tomaselli S, Pagano K, Boulton S, Zanzoni S, Melacini G, Molinari H, Ragona L. Lipid binding protein response to a bile acid library: a combined NMR and statistical approach. The Febs Journal. PMID 26260520 DOI: 10.1111/Febs.13405 |
0.411 |
|
| 2015 |
Moleschi KJ, Akimoto M, Melacini G. Measurement of State-Specific Association Constants in Allosteric Sensors through Molecular Stapling and NMR. Journal of the American Chemical Society. PMID 26247242 DOI: 10.1021/Jacs.5B06557 |
0.392 |
|
| 2015 |
Fogolari F, Corazza A, Fortuna S, Soler MA, VanSchouwen B, Brancolini G, Corni S, Melacini G, Esposito G. Distance-Based Configurational Entropy of Proteins from Molecular Dynamics Simulations. Plos One. 10: e0132356. PMID 26177039 DOI: 10.1371/Journal.Pone.0132356 |
0.369 |
|
| 2015 |
VanSchouwen B, Akimoto M, Sayadi M, Fogolari F, Melacini G. Role of Dynamics in the Autoinhibition and Activation of the Hyperpolarization-activated Cyclic Nucleotide-modulated (HCN) Ion Channels. The Journal of Biological Chemistry. 290: 17642-54. PMID 25944904 DOI: 10.1074/Jbc.M115.651877 |
0.417 |
|
| 2015 |
Zhu Y, Chen H, Boulton S, Mei F, Ye N, Melacini G, Zhou J, Cheng X. Biochemical and pharmacological characterizations of ESI-09 based EPAC inhibitors: defining the ESI-09 "therapeutic window". Scientific Reports. 5: 9344. PMID 25791905 DOI: 10.1038/Srep09344 |
0.378 |
|
| 2015 |
Boulton S, Akimoto M, Selvaratnam R, Bashiri A, Melacini G. A Tool Set to Map Dynamic Allosteric Networks through the NMR Chemical Shift Covariance Analysis (CHESCA) Biophysical Journal. 108: 60a. DOI: 10.1016/J.Bpj.2014.11.363 |
0.721 |
|
| 2014 |
Boulton S, Akimoto M, Selvaratnam R, Bashiri A, Melacini G. A tool set to map allosteric networks through the NMR chemical shift covariance analysis. Scientific Reports. 4: 7306. PMID 25482377 DOI: 10.1038/Srep07306 |
0.712 |
|
| 2014 |
Moleschi K, Melacini G. Signaling at crossroads: The dialogue between PDEs and PKA is spoken in multiple languages Biophysical Journal. 107: 1259-1260. PMID 25229132 DOI: 10.1016/J.Bpj.2014.07.051 |
0.433 |
|
| 2014 |
Akimoto M, Zhang Z, Boulton S, Selvaratnam R, Van Schouwen B, Gloyd M, Accili EA, Lange OF, Melacini G. A mechanism for the auto-inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel opening and its relief by cAMP Journal of Biological Chemistry. 289: 22205-22220. PMID 24878962 DOI: 10.1074/Jbc.M114.572164 |
0.702 |
|
| 2014 |
Boulton S, Akimoto M, VanSchouwen B, Moleschi K, Selvaratnam R, Giri R, Melacini G. Tapping the translation potential of cAMP signalling: molecular basis for selectivity in cAMP agonism and antagonism as revealed by NMR. Biochemical Society Transactions. 42: 302-7. PMID 24646235 DOI: 10.1042/Bst20130282 |
0.729 |
|
| 2014 |
Akimoto M, Moleschi K, Boulton S, VanSchouwen B, Selvaratnam R, Taylor SS, Melacini G. Allosteric linkers in cAMP signalling. Biochemical Society Transactions. 42: 139-44. PMID 24450641 DOI: 10.1042/Bst20130257 |
0.715 |
|
| 2014 |
Matthews LA, Selvaratnam R, Jones DR, Akimoto M, McConkey BJ, Melacini G, Duncker BP, Guarné A. A novel non-canonical forkhead-associated (FHA) domain-binding interface mediates the interaction between Rad53 and Dbf4 proteins. The Journal of Biological Chemistry. 289: 2589-99. PMID 24285546 DOI: 10.1074/Jbc.M113.517060 |
0.701 |
|
| 2014 |
Huang GY, Kim JJ, Reger AS, Lorenz R, Moon EW, Zhao C, Casteel DE, Bertinetti D, Vanschouwen B, Selvaratnam R, Pflugrath JW, Sankaran B, Melacini G, Herberg FW, Kim C. Structural basis for cyclic-nucleotide selectivity and cGMP-selective activation of PKG i Structure. 22: 116-124. PMID 24239458 DOI: 10.1016/J.Str.2013.09.021 |
0.734 |
|
| 2014 |
Milojevic J, Costa M, Ortiz AM, Jorquera JI, Melacini G. In vitro amyloid-β binding and inhibition of amyloid-β self-association by therapeutic albumin Journal of Alzheimer's Disease. 38: 753-765. PMID 24072068 DOI: 10.3233/Jad-131169 |
0.799 |
|
| 2014 |
Boulton S, Akimoto M, Selvaratnam R, Bashiri A, Melacini G. A tool set to map allosteric networks through the NMR chemical shift covariance analysis Scientific Reports. 4. DOI: 10.1038/srep07306 |
0.641 |
|
| 2014 |
Algamal M, Milojevic J, Jafari N, Zhang S, Selvaratnam R, Melacini G. Finding Order in Disorder: Probing Transient Functional States in the Amyloidogenic Alzheimer's Aβ Peptide Using the NMR Chemical Shift Covariance Analysis (CHESCA) Biophysical Journal. 106: 236a. DOI: 10.1016/J.Bpj.2013.11.1386 |
0.798 |
|
| 2013 |
Algamal M, Milojevic J, Jafari N, Zhang W, Melacini G. Mapping the Interactions between the Alzheimer's Aβ-Peptide and human serum albumin beyond domain resolution Biophysical Journal. 105: 1700-1709. PMID 24094411 DOI: 10.1016/J.Bpj.2013.08.025 |
0.794 |
|
| 2013 |
Son I, Selvaratnam R, Dubins DN, Melacini G, Chalikian TV. Ultrasonic and densimetric characterization of the association of cyclic AMP with the cAMP-binding domain of the exchange protein EPAC1 Journal of Physical Chemistry B. 117: 10779-10784. PMID 23968295 DOI: 10.1021/Jp406451P |
0.718 |
|
| 2013 |
Akimoto M, Selvaratnam R, McNicholl ET, Verma G, Taylor SS, Melacini G. Signaling through dynamic linkers as revealed by PKA. Proceedings of the National Academy of Sciences of the United States of America. 110: 14231-6. PMID 23946424 DOI: 10.1073/Pnas.1312644110 |
0.701 |
|
| 2013 |
Raditsis AV, Milojevic J, Melacini G. Aβ association inhibition by transferrin Biophysical Journal. 105: 473-480. PMID 23870268 DOI: 10.1016/J.Bpj.2013.03.065 |
0.787 |
|
| 2013 |
Barker CA, Allison SE, Zlitni S, Nguyen ND, Das R, Melacini G, Capretta AA, Brown ED. Degradation of MAC13243 and studies of the interaction of resulting thiourea compounds with the lipoprotein targeting chaperone LolA. Bioorganic & Medicinal Chemistry Letters. 23: 2426-31. PMID 23473681 DOI: 10.1016/J.Bmcl.2013.02.005 |
0.525 |
|
| 2013 |
Huang GY, Kim JJ, Reger AS, Lorenz R, Moon E, Zhao C, Casteel DE, Bertinetti D, VanSchouwen B, Selvaratnam R, Pflugrath JW, Sankaran B, Melacini G, Herberg FW, Kim C. Structures of human PKG reveal cGMP-selectived activation mechanisms Bmc Pharmacology and Toxicology. 14. DOI: 10.1186/2050-6511-14-S1-O16 |
0.702 |
|
| 2013 |
Barker CA, Allison SE, Zlitni S, Nguyen ND, Das R, Melacini G, Capretta AA, Brown ED. Erratum to “Degradation of MAC13243 and studies of the interaction of resulting thiourea compounds with the lipoprotein targeting chaperone LolA” [Bioorg. Med. Chem. Lett. 23 (2013) 2426–2431] Bioorganic & Medicinal Chemistry Letters. 23: 4469-4470. DOI: 10.1016/J.Bmcl.2013.05.085 |
0.475 |
|
| 2012 |
Selvaratnam R, Mazhab-Jafari MT, Das R, Melacini G. The Auto-Inhibitory Role of the EPAC Hinge Helix as Mapped by NMR Plos One. 7. PMID 23185272 DOI: 10.1371/Journal.Pone.0048707 |
0.78 |
|
| 2012 |
Selvaratnam R, Vanschouwen B, Fogolari F, Mazhab-Jafari MT, Das R, Melacini G. The projection analysis of NMR chemical shifts reveals extended EPAC autoinhibition determinants Biophysical Journal. 102: 630-639. PMID 22325287 DOI: 10.1016/J.Bpj.2011.12.030 |
0.769 |
|
| 2012 |
Selvaratnam R, Akimoto M, VanSchouwen B, Melacini G. cAMP-dependent allostery and dynamics in Epac: An NMR view Biochemical Society Transactions. 40: 219-223. PMID 22260694 DOI: 10.1042/Bst20110628 |
0.74 |
|
| 2011 |
VanSchouwen B, Selvaratnam R, Fogolari F, Melacini G. Role of dynamics in the autoinhibition and activation of the exchange protein directly activated by cyclic AMP (EPAC) Journal of Biological Chemistry. 286: 42655-42669. PMID 21873431 DOI: 10.1074/Jbc.M111.277723 |
0.724 |
|
| 2011 |
Selvaratnam R, Chowdhury S, VanSchouwena B, Melacini G. Mapping allostery through the covariance analysis of NMR chemical shifts Proceedings of the National Academy of Sciences of the United States of America. 108: 6133-6138. PMID 21444788 DOI: 10.1073/Pnas.1017311108 |
0.738 |
|
| 2011 |
Milojevic J, Melacini G. Stoichiometry and affinity of the human serum albumin-Alzheimer's Aβ peptide interactions Biophysical Journal. 100: 183-192. PMID 21190670 DOI: 10.1016/J.Bpj.2010.11.037 |
0.807 |
|
| 2010 |
McNicholl ET, Das R, SilDas S, Taylor SS, Melacini G. Communication between tandem cAMP binding domains in the regulatory subunit of protein kinase A-Ialpha as revealed by domain-silencing mutations. The Journal of Biological Chemistry. 285: 15523-37. PMID 20202931 DOI: 10.1074/Jbc.M110.105783 |
0.586 |
|
| 2009 |
Milojevic J, Raditsis A, Melacini G. Human serum albumin inhibits Aβ fibrillization through a "monomer-competitor" mechanism Biophysical Journal. 97: 2585-2594. PMID 19883602 DOI: 10.1016/J.Bpj.2009.08.028 |
0.776 |
|
| 2009 |
Pathania R, Zlitni S, Barker C, Das R, Gerritsma DA, Lebert J, Awuah E, Melacini G, Capretta FA, Brown ED. Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting Nature Chemical Biology. 5: 849-856. PMID 19783991 DOI: 10.1038/Nchembio.221 |
0.499 |
|
| 2009 |
Kooistra J, Milojevic J, Melacini G, Ortega J. A new function of human htra2 as an amyloid-β oligomerization inhibitor Journal of Alzheimer's Disease. 17: 281-294. PMID 19502709 DOI: 10.3233/Jad-2009-1037 |
0.78 |
|
| 2009 |
Das R, Chowdhury S, Mazhab-Jafari MT, SilDas S, Selvaratnam R, Melacini G. Dynamically driven ligand selectivity in cyclic nucleotide binding domains Journal of Biological Chemistry. 284: 23682-23696. PMID 19403523 DOI: 10.1074/Jbc.M109.011700 |
0.777 |
|
| 2009 |
Gavina JMA, Mazhab-Jafari MT, Melacini G, Britz-McKibbin P. Label-free assay for thermodynamic analysis of protein-ligand interactions: A multivariate strategy for allosteric ligand screening Biochemistry. 48: 223-225. PMID 19113833 DOI: 10.1021/Bi802121G |
0.382 |
|
| 2008 |
Das R, Mazhab-Jafari MT, Chowdhury S, SilDas S, Selvaratnam R, Melacini G. Entropy-driven cAMP-dependent allosteric control of inhibitory interactions in exchange proteins directly activated by cAMP Journal of Biological Chemistry. 283: 19691-19703. PMID 18411261 DOI: 10.1074/Jbc.M802164200 |
0.755 |
|
| 2008 |
Huang H, Milojevic J, Melacini G. Analysis and optimization of saturation transfer difference NMR experiments designed to map early self-association events in amyloidogenic peptides. The Journal of Physical Chemistry. B. 112: 5795-802. PMID 18410162 DOI: 10.1021/Jp7118718 |
0.782 |
|
| 2008 |
Huang H, Milojevic J, Melacini G. Analysis and optimization of saturation transfer difference NMR experiments designed to map early self-association events in amyloidogenic peptides Journal of Physical Chemistry B. 112: 5795-5802. DOI: 10.1021/jp7118718 |
0.757 |
|
| 2007 |
Mazhab-Jafari MT, Das R, Fotheringham SA, SilDas S, Chowdhury S, Melacini G. Understanding cAMP-dependent allostery by NMR spectroscopy: Comparative analysis of the EPAC1 cAMP-binding domain in its apo and cAMP-bound states Journal of the American Chemical Society. 129: 14482-14492. PMID 17973384 DOI: 10.1021/Ja0753703 |
0.623 |
|
| 2007 |
Abu-Abed M, Das R, Wang L, Melacini G. Definition of an electrostatic relay switch critical for the cAMP-dependent activation of protein kinase A as revealed by the D170A mutant of RIα Proteins: Structure, Function and Genetics. 69: 112-124. PMID 17596845 DOI: 10.1002/Prot.21446 |
0.596 |
|
| 2007 |
Milojevic J, Esposito V, Das R, Melacini G. Understanding the molecular basis for the inhibition of the Alzheimer's Aβ-peptide oligomerization by human serum albumin using saturation transfer difference and off-resonance relaxation NMR spectroscopy Journal of the American Chemical Society. 129: 4282-4290. PMID 17367135 DOI: 10.1021/Ja067367+ |
0.806 |
|
| 2007 |
Das R, Esposito V, Abu-Abed M, Anand GS, Taylor SS, Melacini G. cAMP activation of PKA defines an ancient signaling mechanism Proceedings of the National Academy of Sciences of the United States of America. 104: 93-98. PMID 17182741 DOI: 10.1073/Pnas.0609033103 |
0.585 |
|
| 2007 |
Das R, Melacini G. A model for agonism and antagonism in an ancient and ubiquitous cAMP-binding domain Journal of Biological Chemistry. 282: 581-593. PMID 17074757 DOI: 10.1074/Jbc.M607706200 |
0.562 |
|
| 2006 |
Huang H, Melacini G. High-resolution protein hydration NMR experiments: probing how protein surfaces interact with water and other non-covalent ligands. Analytica Chimica Acta. 564: 1-9. PMID 17723356 DOI: 10.1016/J.Aca.2005.10.049 |
0.424 |
|
| 2006 |
Milojevic J, Esposito V, Das R, Melacini G. Analysis and parametric optimization of 1H off-resonance relaxation NMR experiments designed to map polypeptide self-recognition and other noncovalent interactions. The Journal of Physical Chemistry. B. 110: 20664-70. PMID 17034257 DOI: 10.1021/Jp063194Z |
0.783 |
|
| 2006 |
Esposito V, Sjoberg T, Das R, Brown S, Taylor SS, Melacini G. NMR assignment of the cAMP-binding domain A of the PKA regulatory subunit [62] Journal of Biomolecular Nmr. 36: 64. PMID 17016670 DOI: 10.1007/S10858-006-9050-9 |
0.579 |
|
| 2006 |
Das R, Abu-Abed M, Melacini G. Mapping allostery through equilibrium perturbation NMR spectroscopy Journal of the American Chemical Society. 128: 8406-8407. PMID 16802799 DOI: 10.1021/Ja060046D |
0.558 |
|
| 2006 |
Milojevic J, Esposito V, Das R, Melacini G. Analysis and parametric optimization of1H off-resonance relaxation NMR experiments designed, to map polypeptide self-recognition and other noncovalent interactions Journal of Physical Chemistry B. 110: 20664-20670. DOI: 10.1021/jp063194z |
0.782 |
|
| 2005 |
Esposito V, Das R, Melacini G. Mapping polypeptide self-recognition through 1H off-resonance relaxation Journal of the American Chemical Society. 127: 9358-9359. PMID 15984849 DOI: 10.1021/Ja051714I |
0.578 |
|
| 2005 |
Prieto JH, Sampoli Benitez BA, Melacini G, Johnson DA, Wood MJ, Komives EA. Dynamics of the fragment of thrombomodulin containing the fourth and fifth epidermal growth factor-like domains correlate with function. Biochemistry. 44: 1225-33. PMID 15667216 DOI: 10.1021/Bi0478852 |
0.393 |
|
| 2004 |
Rodríguez JC, Jennings PA, Melacini G. Using chemical exchange to assign non-covalent protein complexes in slow exchange with the free state: enhanced resolution and efficient signal editing. Journal of Biomolecular Nmr. 30: 155-61. PMID 15557802 DOI: 10.1023/B:Jnmr.0000048857.44219.C3 |
0.416 |
|
| 2004 |
Epand RM, Epand RF, Sayer BG, Melacini G, Palgulachari MN, Segrest JP, Anantharamaiah GM. An Apolipoprotein AI Mimetic Peptide: Membrane Interactions and the Role of Cholesterol Biochemistry. 43: 5073-5083. PMID 15109266 DOI: 10.1021/Bi049786U |
0.31 |
|
| 2003 |
Wood MJ, Becvar LA, Prieto JH, Melacini G, Komives EA. NMR structures reveal how oxidation inactivates thrombomodulin. Biochemistry. 42: 11932-42. PMID 14556624 DOI: 10.1021/Bi034646Q |
0.391 |
|
| 2003 |
Fayos R, Melacini G, Newlon MG, Burns L, Scott JD, Jennings PA. Induction of flexibility through protein-protein interactions. The Journal of Biological Chemistry. 278: 18581-7. PMID 12604595 DOI: 10.1074/Jbc.M300866200 |
0.338 |
|
| 2002 |
Glover KJ, Whiles JA, Vold RR, Melacini G. Position of residues in transmembrane peptides with respect to the lipid bilayer: a combined lipid Noes and water chemical exchange approach in phospholipid bicelles. Journal of Biomolecular Nmr. 22: 57-64. PMID 11885981 DOI: 10.1023/A:1013817818794 |
0.319 |
|
| 2001 |
Glover KJ, Whiles JA, Wood MJ, Melacini G, Komives EA, Vold RR. Conformational dimorphism and transmembrane orientation of prion protein residues 110-136 in bicelles. Biochemistry. 40: 13137-42. PMID 11683621 DOI: 10.1021/Bi011485M |
0.36 |
|
| 2000 |
Melacini G, Bonvin AM, Goodman M, Boelens R, Kaptein R. Hydration dynamics of the collagen triple helix by NMR. Journal of Molecular Biology. 300: 1041-9. PMID 10903852 DOI: 10.1006/Jmbi.2000.3919 |
0.795 |
|
| 2000 |
Spronk CAEM, Bonvin AMJJ, Radha PK, Melacini G, Boelens R, Kaptein R. Nmr Structure Of Lac Repressor Hp62-Dna Complex Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb1Cjg/Pdb |
0.711 |
|
| 2000 |
Goodman M, Kwak J, Locardi E, Melacini G. Synthesis and biophysics of triple helical collagen mimetics American Chemical Society, Polymer Preprints, Division of Polymer Chemistry. 41: 920-921. |
0.349 |
|
| 1999 |
Melacini G, Boelens R, Kaptein R. Band-selective editing of exchange-relay in protein-water NOE experiments. Journal of Biomolecular Nmr. 13: 67-71. PMID 21080264 DOI: 10.1023/A:1008350918005 |
0.724 |
|
| 1999 |
Melacini G, Boelens R, Kaptein R. Water-macromolecule interactions by NMR: a quadrature-free constant-time approach and its application to CI2. Journal of Biomolecular Nmr. 15: 189-201. PMID 10677822 DOI: 10.1023/A:1008316612907 |
0.734 |
|
| 1999 |
Spronk CA, Bonvin AM, Radha PK, Melacini G, Boelens R, Kaptein R. The solution structure of Lac repressor headpiece 62 complexed to a symmetrical lac operator. Structure (London, England : 1993). 7: 1483-92. PMID 10647179 DOI: 10.1016/S0969-2126(00)88339-2 |
0.786 |
|
| 1999 |
Nooren IM, Rietveld AW, Melacini G, Sauer RT, Kaptein R, Boelens R. The solution structure and dynamics of an Arc repressor mutant reveal premelting conformational changes related to DNA binding. Biochemistry. 38: 6035-42. PMID 10320329 DOI: 10.1021/Bi982677T |
0.756 |
|
| 1999 |
Melacini G, Kaptein R, Boelens R. Editing of chemical exchange-relayed NOEs in NMR experiments for the observation of protein-water interactions. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 136: 214-8. PMID 9986764 DOI: 10.1006/Jmre.1998.1646 |
0.732 |
|
| 1998 |
Melacini G, Goodman M. Improved method for the stereospecific 1H-NMR assignments in collagen- like triple-helices Chirality. 10: 28-34. DOI: 10.1002/(Sici)1520-636X(1998)10:1/2<28::Aid-Chir6>3.0.Co;2-R |
0.466 |
|
| 1997 |
Melacini G, Feng Y, Goodman M. Collagen-based structures containing the peptoid residue N-isobutylglycine (Nleu): conformational analysis of Gly-Nleu-Pro sequences by 1H-NMR and molecular modeling. Biochemistry. 36: 8725-32. PMID 9220959 DOI: 10.1021/Bi962981R |
0.515 |
|
| 1997 |
Feng Y, Melacini G, Goodman M. Collagen-based structures containing the peptoid residue N-isobutylglycine (Nleu): synthesis and biophysical studies of Gly-Nleu-Pro sequences by circular dichroism and optical rotation. Biochemistry. 36: 8716-24. PMID 9220958 DOI: 10.1021/Bi962980Z |
0.493 |
|
| 1997 |
Melacini G, Zhu Q, Osapay G, Goodman M. A refined model for the somatostatin pharmacophore: conformational analysis of lanthionine-sandostatin analogs. Journal of Medicinal Chemistry. 40: 2252-8. PMID 9216844 DOI: 10.1021/Jm960851A |
0.509 |
|
| 1997 |
Osapay G, Prokai L, Kim HS, Medzihradszky KF, Coy DH, Liapakis G, Reisine T, Melacini G, Zhu Q, Wang SH, Mattern RH, Goodman M. Lanthionine-somatostatin analogs: synthesis, characterization, biological activity, and enzymatic stability studies. Journal of Medicinal Chemistry. 40: 2241-51. PMID 9216843 DOI: 10.1021/Jm960850I |
0.512 |
|
| 1997 |
Melacini G, Zhu Q, Goodman M. Multiconformational NMR analysis of sandostatin (octreotide): equilibrium between beta-sheet and partially helical structures. Biochemistry. 36: 1233-41. PMID 9063871 DOI: 10.1021/Bi962497O |
0.523 |
|
| 1996 |
Pegna M, Molinari H, Zetta L, Melacini G, Gibbons WA, Brown F, Rowlands D, Chan E, Mascagni P. The solution conformational features of two highly homologous antigenic peptides of foot-and-mouth disease virus serotype A, variant A and USA, correlate with their serological properties. Journal of Peptide Science : An Official Publication of the European Peptide Society. 2: 91-105. PMID 9225249 DOI: 10.1002/Psc.50 |
0.37 |
|
| 1996 |
Feng Y, Melacini G, Taulane JP, Goodman M. Collagen-based structures containing the peptoid residue N-isobutylglycine (Nleu): synthesis and biophysical studies of Gly-Pro-Nleu sequences by circular dichroism, ultraviolet absorbance, and optical rotation. Biopolymers. 39: 859-72. PMID 8946805 DOI: 10.1002/(Sici)1097-0282(199612)39:6<859::Aid-Bip10>3.0.Co;2-Z |
0.501 |
|
| 1996 |
Melacini G, Feng Y, Goodman M. Collagen-based structures containing the peptoid residue N-isobutylglycine (Nleu). 6. Conformational analysis of Gly-Pro-Nleu sequences by 1H NMR, CD, and molecular modeling Journal of the American Chemical Society. 118: 10725-10732. DOI: 10.1021/Ja9617193 |
0.492 |
|
| 1996 |
Goodman M, Melacini G, Feng Y. Collagen-like triple helices incorporating peptoid residues Journal of the American Chemical Society. 118: 10928-10929. DOI: 10.1021/Ja961717I |
0.487 |
|
| 1996 |
Melacini G, Feng Y, Goodman M. Acetyl-terminated and template-assembled collagen-based polypeptides composed of Gly-Pro-Hyp sequences. 3. Conformational analysis by 1H-NMR and molecular modeling studies Journal of the American Chemical Society. 118: 10359-10364. DOI: 10.1021/Ja9612615 |
0.499 |
|
| 1996 |
Feng Y, Melacini G, Taulane JP, Goodman M. Acetyl-terminated and template-assembled collagen-based polypeptides composed of Gly-Pro-Hyp sequences. 2. Synthesis and conformational analysis by circular dichroism, ultraviolet absorbance, and optical rotation Journal of the American Chemical Society. 118: 10351-10358. DOI: 10.1021/Ja961260C |
0.485 |
|
| 1996 |
Goodman M, Feng Y, Melacini G, Taulane JP. A template-induced incipient collagen-like triple-helical structure Journal of the American Chemical Society. 118: 5156-5157. DOI: 10.1021/Ja954132H |
0.387 |
|
| 1994 |
Ösapay G, Melacini G, Zhu Q, Tehrani L, Goodman M. Synthesis and physicochemical characterization of the lanthionine analog of somatostatin[1-14] Letters in Peptide Science. 1: 81-87. DOI: 10.1007/Bf00126277 |
0.506 |
|
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