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Mark Anthony Smith, PhD, Nottingham, FRCPath - Publications

Affiliations: 
Pathology Case Western Reserve University, Cleveland Heights, OH, United States 
Area:
alzheimer's disease, pathology, oxidative stress
Website:
http://path-www.path.cwru.edu/information6.php?info_id=44
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Year Citation  Score
2019 Sharma A, Castellani RJ, Smith MA, Muresanu DF, Dey PK, Sharma HS. 5-Hydroxytryptophan: A precursor of serotonin influences regional blood-brain barrier breakdown, cerebral blood flow, brain edema formation, and neuropathology. International Review of Neurobiology. 146: 1-44. PMID 31349924 DOI: 10.1016/bs.irn.2019.06.005  0.302
2018 Smith MA, Bowen RL, Nguyen RQ, Perry G, Atwood CS, Rimm AA. Putative Gonadotropin Releasing Hormone Agonist Therapy and Dementia: An Application of Medicare Hospitalization Claims Data. Journal of Alzheimer's Disease : Jad. PMID 29782310 DOI: 10.3233/Jad-170847  0.816
2017 Henderson LE, Abdelmegeed MA, Yoo SH, Rhee SG, Zhu X, Smith MA, Nguyen RQ, Perry G, Song BJ. Enhanced Phosphorylation of Bax and Its Translocation into Mitochondria in the Brains of Individuals Affiliated with Alzheimer's Disease. The Open Neurology Journal. 11: 48-58. PMID 29290835 DOI: 10.2174/1874205X01711010048  0.859
2015 Bowen RL, Perry G, Xiong C, Smith MA, Atwood CS. A clinical study of lupron depot in the treatment of women with Alzheimer's disease: preservation of cognitive function in patients taking an acetylcholinesterase inhibitor and treated with high dose lupron over 48 weeks. Journal of Alzheimer's Disease : Jad. 44: 549-60. PMID 25310993 DOI: 10.3233/Jad-141626  0.796
2014 Bonda DJ, Wang X, Lee HG, Smith MA, Perry G, Zhu X. Neuronal failure in Alzheimer's disease: a view through the oxidative stress looking-glass. Neuroscience Bulletin. 30: 243-52. PMID 24733654 DOI: 10.1007/S12264-013-1424-X  0.877
2014 Palm R, Chang J, Blair J, Garcia-Mesa Y, Lee HG, Castellani RJ, Smith MA, Zhu X, Casadesus G. Down-regulation of serum gonadotropins but not estrogen replacement improves cognition in aged-ovariectomized 3xTg AD female mice. Journal of Neurochemistry. 130: 115-25. PMID 24601954 DOI: 10.1111/jnc.12706  0.829
2014 Blair JA, Siedlak SL, Wolfram JA, Nunomura A, Castellani RJ, Ferreira ST, Klein WL, Wang Y, Casadesus G, Smith MA, Perry G, Zhu X, Lee HG. Accumulation of intraneuronal amyloid-β is common in normal brain. Current Alzheimer Research. 11: 317-24. PMID 24597504 DOI: 10.2174/1567205011666140302200902  0.85
2014 Adler BL, Yarchoan M, Hwang HM, Louneva N, Blair JA, Palm R, Smith MA, Lee HG, Arnold SE, Casadesus G. Neuroprotective effects of the amylin analogue pramlintide on Alzheimer's disease pathogenesis and cognition. Neurobiology of Aging. 35: 793-801. PMID 24239383 DOI: 10.1016/J.Neurobiolaging.2013.10.076  0.828
2014 Bonda DJ, Stone JG, Torres SL, Siedlak SL, Perry G, Kryscio R, Jicha G, Casadesus G, Smith MA, Zhu X, Lee HG. Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance. Journal of Neurochemistry. 128: 162-72. PMID 23895348 DOI: 10.1111/Jnc.12380  0.844
2013 Williams WM, Torres S, Siedlak SL, Castellani RJ, Perry G, Smith MA, Zhu X. Antimicrobial peptide β-defensin-1 expression is upregulated in Alzheimer's brain. Journal of Neuroinflammation. 10: 127. PMID 24139179 DOI: 10.1186/1742-2094-10-127  0.828
2013 Hou L, Lee HG, Han F, Tedesco JM, Perry G, Smith MA, Zagorski MG. Modification of amyloid-β1-42 fibril structure by methionine-35 oxidation. Journal of Alzheimer's Disease : Jad. 37: 9-18. PMID 23719512 DOI: 10.3233/Jad-122389  0.811
2013 Perry EA, Castellani RJ, Moreira PI, Nunomura A, Lui Q, Harris PL, Sayre LM, Szweda PA, Szweda LI, Zhu X, Smith MA, Perry G. Neurofilaments are the major neuronal target of hydroxynonenal-mediated protein cross-links. Free Radical Research. 47: 507-10. PMID 23566300 DOI: 10.3109/10715762.2013.794265  0.813
2013 Tatsuoka C, Tseng H, Jaeger J, Varadi F, Smith MA, Yamada T, Smyth KA, Lerner AJ. Modeling the heterogeneity in risk of progression to Alzheimer's disease across cognitive profiles in mild cognitive impairment. Alzheimer's Research & Therapy. 5: 14. PMID 23497709 DOI: 10.1186/Alzrt168  0.325
2013 Perry G, Zhu X, Smith MA, Sorensen A, Avila J. Preface. Alzheimer's disease: advances for a new century. Journal of Alzheimer's Disease : Jad. 33: S1. PMID 23397602  0.828
2013 Santos RX, Correia SC, Zhu X, Smith MA, Moreira PI, Castellani RJ, Nunomura A, Perry G. Mitochondrial DNA oxidative damage and repair in aging and Alzheimer's disease. Antioxidants & Redox Signaling. 18: 2444-57. PMID 23216311 DOI: 10.1089/Ars.2012.5039  0.846
2013 Correia SC, Santos RX, Santos MS, Casadesus G, Lamanna JC, Perry G, Smith MA, Moreira PI. Mitochondrial abnormalities in a streptozotocin-induced rat model of sporadic Alzheimer's disease. Current Alzheimer Research. 10: 406-19. PMID 23061885 DOI: 10.2174/1567205011310040006  0.805
2013 Zhu X, Perry G, Smith MA, Wang X. Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 33: S253-62. PMID 22531428 DOI: 10.3233/Jad-2012-129005  0.835
2013 Perry G, Zhu X, Smith MA, Sorensen A, Avila J. Alzheimer's disease: Advances for a new century Journal of Alzheimer's Disease. 33: S1. DOI: 10.3233/JAD-2012-129045  0.843
2013 Sharma HS, Castellani RJ, Muresanu DF, Smith MA, Patnaik R, Moessler H, Sharma A. Diabetes exacerbates Alzheimer's disease induced brain pathology. Possible neuroprotective effects of Cerebrolysin Journal of the Neurological Sciences. 333. DOI: 10.1016/J.Jns.2013.07.1131  0.411
2013 Bonda D, Stone J, Richardson S, Siedlak S, Perry G, Casadesus G, Smith M, Zhu X, Lee H. P3-067: Neuronal leptin resistance in Alzheimer's disease Alzheimer's & Dementia. 9: P574-P575. DOI: 10.1016/J.Jalz.2013.05.1137  0.835
2012 Rodrigues R, Smith MA, Wang X, Perry G, Lee HG, Zhu X, Petersen RB. Molecular neuropathogenesis of Alzheimer's disease: an interaction model stressing the central role of oxidative stress. Future Neurology. 7: 287-305. PMID 23086377 DOI: 10.2217/Fnl.12.27  0.829
2012 Greco SJ, Hamzelou A, Johnston JM, Richardson S, Smith MA, Perry G, Ashford JW, Tezapsidis N. Isotyping the human TOMM40 variable-length polymorphism by gene amplification and restriction digest. Current Alzheimer Research. 9: 1168-73. PMID 22950840 DOI: 10.2174/156720512804142921  0.555
2012 Sharma HS, Castellani RJ, Smith MA, Sharma A. The blood-brain barrier in Alzheimer's disease: novel therapeutic targets and nanodrug delivery. International Review of Neurobiology. 102: 47-90. PMID 22748826 DOI: 10.1016/B978-0-12-386986-9.00003-X  0.732
2012 Nunomura A, Moreira PI, Castellani RJ, Lee HG, Zhu X, Smith MA, Perry G. Oxidative damage to RNA in aging and neurodegenerative disorders. Neurotoxicity Research. 22: 231-48. PMID 22669748 DOI: 10.1007/s12640-012-9331-x  0.816
2012 Williams WM, Castellani RJ, Weinberg A, Perry G, Smith MA. Do β-defensins and other antimicrobial peptides play a role in neuroimmune function and neurodegeneration? Thescientificworldjournal. 2012: 905785. PMID 22606066 DOI: 10.1100/2012/905785  0.757
2012 Kudo W, Lee HP, Smith MA, Zhu X, Matsuyama S, Lee HG. Inhibition of Bax protects neuronal cells from oligomeric Aβ neurotoxicity. Cell Death & Disease. 3: e309. PMID 22592316 DOI: 10.1038/cddis.2012.43  0.825
2012 Casadesús G, Gutierrez-Cuesta J, Lee HG, Jiménez A, Tajes M, Ortuño-Sahagún D, Camins A, Smith MA, Pallàs M. Neuronal cell cycle re-entry markers are altered in the senescence accelerated mouse P8 (SAMP8). Journal of Alzheimer's Disease : Jad. 30: 573-83. PMID 22451322 DOI: 10.3233/JAD-2012-120112  0.832
2012 Palm R, Ayala-Fontanez N, Garcia Y, Lee HG, Smith MA, Casadesus G. Neuroendocrinology-based therapy for Alzheimer's disease. Biofactors (Oxford, England). 38: 123-32. PMID 22438197 DOI: 10.1002/biof.1011  0.817
2012 Correia SC, Santos RX, Perry G, Zhu X, Moreira PI, Smith MA. Mitochondrial importance in Alzheimer's, Huntington's and Parkinson's diseases. Advances in Experimental Medicine and Biology. 724: 205-21. PMID 22411245 DOI: 10.1007/978-1-4614-0653-2_16  0.829
2012 Jeyaraj D, Scheer FA, Ripperger JA, Haldar SM, Lu Y, Prosdocimo DA, Eapen SJ, Eapen BL, Cui Y, Mahabeleshwar GH, Lee HG, Smith MA, Casadesus G, Mintz EM, Sun H, et al. Klf15 orchestrates circadian nitrogen homeostasis. Cell Metabolism. 15: 311-23. PMID 22405069 DOI: 10.1016/J.Cmet.2012.01.020  0.774
2012 Wang X, Snape M, Klann E, Stone JG, Singh A, Petersen RB, Castellani RJ, Casadesus G, Smith MA, Zhu X. Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome. Journal of Neurochemistry. 121: 672-9. PMID 22393900 DOI: 10.1111/J.1471-4159.2012.07722.X  0.783
2012 Nunomura A, Tamaoki T, Motohashi N, Nakamura M, McKeel DW, Tabaton M, Lee HG, Smith MA, Perry G, Zhu X. The earliest stage of cognitive impairment in transition from normal aging to Alzheimer disease is marked by prominent RNA oxidation in vulnerable neurons. Journal of Neuropathology and Experimental Neurology. 71: 233-41. PMID 22318126 DOI: 10.1097/NEN.0b013e318248e614  0.837
2012 Lee HP, Pancholi N, Esposito L, Previll LA, Wang X, Zhu X, Smith MA, Lee HG. Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity. Plos One. 7: e28033. PMID 22276093 DOI: 10.1371/Journal.Pone.0028033  0.824
2012 Bonda DJ, Liu G, Men P, Perry G, Smith MA, Zhu X. Nanoparticle delivery of transition-metal chelators to the brain: Oxidative stress will never see it coming! Cns & Neurological Disorders Drug Targets. 11: 81-5. PMID 22229318 DOI: 10.2174/187152712799960709  0.811
2012 Santos RX, Correia SC, Zhu X, Lee HG, Petersen RB, Nunomura A, Smith MA, Perry G, Moreira PI. Nuclear and mitochondrial DNA oxidation in Alzheimer's disease. Free Radical Research. 46: 565-76. PMID 22149654 DOI: 10.3109/10715762.2011.648188  0.831
2012 Zhu X, Castellani RJ, Moreira PI, Aliev G, Shenk JC, Siedlak SL, Harris PL, Fujioka H, Sayre LM, Szweda PA, Szweda LI, Smith MA, Perry G. Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover. Free Radical Biology & Medicine. 52: 699-704. PMID 22137893 DOI: 10.1016/J.Freeradbiomed.2011.11.004  0.844
2012 Kudo W, Lee HP, Zou WQ, Wang X, Perry G, Zhu X, Smith MA, Petersen RB, Lee HG. Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death. Human Molecular Genetics. 21: 1138-44. PMID 22100763 DOI: 10.1093/Hmg/Ddr542  0.827
2012 Chang J, Rimando A, Pallas M, Camins A, Porquet D, Reeves J, Shukitt-Hale B, Smith MA, Joseph JA, Casadesus G. Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease. Neurobiology of Aging. 33: 2062-71. PMID 21982274 DOI: 10.1016/J.Neurobiolaging.2011.08.015  0.806
2012 Guglielmotto M, Aragno M, Tamagno E, Vercellinatto I, Visentin S, Medana C, Catalano MG, Smith MA, Perry G, Danni O, Boccuzzi G, Tabaton M. AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation. Neurobiology of Aging. 33: 196.e13-27. PMID 20638753 DOI: 10.1016/j.neurobiolaging.2010.05.026  0.802
2012 Perry G, Zhu X, Smith MA, Sorensen A, Avila J. Preface: Alzheimer's disease: Advances for a new century Advances in Alzheimer's Disease. 3: 1. DOI: 10.3233/978-1-61499-154-0-1  0.837
2011 Williams WM, Weinberg A, Smith MA. Protein modification by dicarbonyl molecular species in neurodegenerative diseases. Journal of Amino Acids. 2011: 461216. PMID 22332001 DOI: 10.4061/2011/461216  0.456
2011 Lee HP, Kudo W, Zhu X, Smith MA, Lee HG. Early induction of c-Myc is associated with neuronal cell death. Neuroscience Letters. 505: 124-7. PMID 22005580 DOI: 10.1016/J.Neulet.2011.10.004  0.813
2011 Castellani RJ, Gupta Y, Sheng B, Siedlak SL, Harris PL, Coller JM, Perry G, Lee HG, Tabaton M, Smith MA, Wang X, Zhu X. A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules. Laboratory Investigation; a Journal of Technical Methods and Pathology. 91: 1777-86. PMID 21968813 DOI: 10.1038/Labinvest.2011.149  0.841
2011 Greco SJ, Hamzelou A, Johnston JM, Smith MA, Ashford JW, Tezapsidis N. Leptin boosts cellular metabolism by activating AMPK and the sirtuins to reduce tau phosphorylation and β-amyloid in neurons. Biochemical and Biophysical Research Communications. 414: 170-4. PMID 21945934 DOI: 10.1016/J.Bbrc.2011.09.050  0.461
2011 Song B, Davis K, Liu XS, Lee HG, Smith M, Liu X. Inhibition of Polo-like kinase 1 reduces beta-amyloid-induced neuronal cell death in Alzheimer's disease. Aging. 3: 846-51. PMID 21931181 DOI: 10.18632/aging.100382  0.755
2011 Liu Q, Xie F, Alvarado-Diaz A, Smith MA, Moreira PI, Zhu X, Perry G. Neurofilamentopathy in neurodegenerative diseases. The Open Neurology Journal. 5: 58-62. PMID 21915226 DOI: 10.2174/1874205X01105010058  0.838
2011 Bonda DJ, Smith MA, Perry G, Lee HG, Wang X, Zhu X. The mitochondrial dynamics of Alzheimer's disease and Parkinson's disease offer important opportunities for therapeutic intervention. Current Pharmaceutical Design. 17: 3374-80. PMID 21902671 DOI: 10.2174/138161211798072562  0.835
2011 Correia SC, Cardoso S, Santos RX, Carvalho C, Santos MS, Perry G, Smith MA, Moreira PI. New insights into the mechanisms of mitochondrial preconditioning-triggered neuroprotection. Current Pharmaceutical Design. 17: 3381-9. PMID 21902670 DOI: 10.2174/138161211798072490  0.793
2011 Wolfram JA, Lesnefsky EJ, Hoit BD, Smith MA, Lee HG. Therapeutic potential of c-Myc inhibition in the treatment of hypertrophic cardiomyopathy. Therapeutic Advances in Chronic Disease. 2: 133-44. PMID 21858245 DOI: 10.1177/2040622310393059  0.691
2011 Yuan Y, Cao P, Smith MA, Kramp K, Huang Y, Hisamoto N, Matsumoto K, Hatzoglou M, Jin H, Feng Z. Dysregulated LRRK2 signaling in response to endoplasmic reticulum stress leads to dopaminergic neuron degeneration in C. elegans. Plos One. 6: e22354. PMID 21857923 DOI: 10.1371/Journal.Pone.0022354  0.367
2011 Stone JG, Casadesus G, Gustaw-Rothenberg K, Siedlak SL, Wang X, Zhu X, Perry G, Castellani RJ, Smith MA. Frontiers in Alzheimer's disease therapeutics. Therapeutic Advances in Chronic Disease. 2: 9-23. PMID 21743833 DOI: 10.1177/2040622310382817  0.859
2011 Wolfram JA, Liner A, Richardson SL, Zhu X, Smith MA, Hoit BD, Lee HG. The role of E2F1 in the development of hypertrophic cardiomyopathy. International Journal of Clinical and Experimental Pathology. 4: 521-5. PMID 21738823  0.766
2011 Stone JG, Siedlak SL, Tabaton M, Hirano A, Castellani RJ, Santocanale C, Perry G, Smith MA, Zhu X, Lee HG. The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies. Journal of Neuropathology and Experimental Neurology. 70: 578-87. PMID 21666500 DOI: 10.1097/Nen.0B013E3182204414  0.852
2011 Nair N, Kudo W, Smith MA, Abrol R, Goddard WA, Reddy VP. Novel purine-based fluoroaryl-1,2,3-triazoles as neuroprotecting agents: synthesis, neuronal cell culture investigations, and CDK5 docking studies. Bioorganic & Medicinal Chemistry Letters. 21: 3957-61. PMID 21641213 DOI: 10.1016/J.Bmcl.2011.05.019  0.782
2011 Moh C, Kubiak JZ, Bajic VP, Zhu X, Smith MA, Lee HG. Cell cycle deregulation in the neurons of Alzheimer's disease. Results and Problems in Cell Differentiation. 53: 565-76. PMID 21630160 DOI: 10.1007/978-3-642-19065-0_23  0.838
2011 Wang X, Su B, Liu W, He X, Gao Y, Castellani RJ, Perry G, Smith MA, Zhu X. DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson's disease. Aging Cell. 10: 807-23. PMID 21615675 DOI: 10.1111/J.1474-9726.2011.00721.X  0.802
2011 Bonda DJ, Castellani RJ, Zhu X, Nunomura A, Lee HG, Perry G, Smith MA. A novel perspective on tau in Alzheimer's disease. Current Alzheimer Research. 8: 639-42. PMID 21605042 DOI: 10.2174/156720511796717131  0.861
2011 Schrag M, Mueller C, Oyoyo U, Smith MA, Kirsch WM. Iron, zinc and copper in the Alzheimer's disease brain: a quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion. Progress in Neurobiology. 94: 296-306. PMID 21600264 DOI: 10.1016/J.Pneurobio.2011.05.001  0.439
2011 Castellani RJ, Smith MA. Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is 'too big to fail'. The Journal of Pathology. 224: 147-52. PMID 21557219 DOI: 10.1002/path.2885  0.734
2011 Britton GB, Smith MA, Perry G, Sambamurti K, Jagannatha Rao KS. Drug discovery for neurodegenerative diseases: challenges and novel biochemical targets dedicated to the memory of Mark A. Smith for his inspiring contribution to Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 24: 1-2. PMID 21525570 DOI: 10.3233/Jad-2011-110021  0.696
2011 Bajić VP, Su B, Lee HG, Kudo W, Siedlak SL, Zivković L, Spremo-Potparević B, Djelic N, Milicevic Z, Singh AK, Fahmy LM, Wang X, Smith MA, Zhu X. Mislocalization of CDK11/PITSLRE, a regulator of the G2/M phase of the cell cycle, in Alzheimer disease. Cellular & Molecular Biology Letters. 16: 359-72. PMID 21461981 DOI: 10.2478/S11658-011-0011-2  0.833
2011 Valdez CM, Phelix CF, Smith MA, Perry G, Santamaria F. Modeling cholesterol metabolism by gene expression profiling in the hippocampus. Molecular Biosystems. 7: 1891-901. PMID 21451815 DOI: 10.1039/c0mb00282h  0.584
2011 Zou WQ, Xiao X, Yuan J, Puoti G, Fujioka H, Wang X, Richardson S, Zhou X, Zou R, Li S, Zhu X, McGeer PL, McGeehan J, Kneale G, Rincon-Limas DE, ... ... Smith MA, et al. Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain. The Journal of Biological Chemistry. 286: 15095-105. PMID 21393248 DOI: 10.1074/Jbc.M110.199356  0.822
2011 Chang KH, Multani PS, Sun KH, Vincent F, de Pablo Y, Ghosh S, Gupta R, Lee HP, Lee HG, Smith MA, Shah K. Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death. Molecular Biology of the Cell. 22: 1452-62. PMID 21389115 DOI: 10.1091/Mbc.E10-07-0654  0.739
2011 Bonda DJ, Lee HG, Camins A, Pallàs M, Casadesus G, Smith MA, Zhu X. The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations. The Lancet. Neurology. 10: 275-9. PMID 21349442 DOI: 10.1016/S1474-4422(11)70013-8  0.855
2011 Bonda DJ, Lee HG, Blair JA, Zhu X, Perry G, Smith MA. Role of metal dyshomeostasis in Alzheimer's disease. Metallomics : Integrated Biometal Science. 3: 267-70. PMID 21298161 DOI: 10.1039/c0mt00074d  0.84
2011 Correia SC, Santos RX, Perry G, Zhu X, Moreira PI, Smith MA. Insulin-resistant brain state: the culprit in sporadic Alzheimer's disease? Ageing Research Reviews. 10: 264-73. PMID 21262392 DOI: 10.1016/J.Arr.2011.01.001  0.799
2011 Hoffman WH, Siedlak SL, Wang Y, Castellani RJ, Smith MA. Oxidative damage is present in the fatal brain edema of diabetic ketoacidosis. Brain Research. 1369: 194-202. PMID 21040714 DOI: 10.1016/J.Brainres.2010.10.085  0.774
2011 Castellani RJ, Nugent SL, Morrison AL, Zhu X, Lee HG, Harris PL, Bajić V, Sharma HS, Chen SG, Oettgen P, Perry G, Smith MA. CD3 in Lewy pathology: does the abnormal recall of neurodevelopmental processes underlie Parkinson's disease. Journal of Neural Transmission (Vienna, Austria : 1996). 118: 23-6. PMID 20972807 DOI: 10.1007/S00702-010-0485-5  0.807
2011 Rothenberg KG, Siedlak SL, Lee HG, Zhu X, Perry G, Smith MA. Neurodegenerative processes in Alzheimer's disease: An overview of pathogenesis with strategic biomarker potential Future Neurology. 6: 173-185. DOI: 10.2217/Fnl.10.81  0.847
2011 Wang X, Smith M, Perry G, Zhu X. Mitochondrial Fragmentation Mediates MPP+ Toxicity in Neurons: Implications for Parkinson's Disease Microscopy and Microanalysis. 17: 196-197. DOI: 10.1017/S1431927611001851  0.822
2011 Lerner A, Gustaw-Rothenberg K, Casadesus G, Smith M. P3-443: All-trans retinoic acid treatment of Alzheimer's disease transgenic mice Alzheimer's & Dementia. 7: S657-S657. DOI: 10.1016/j.jalz.2011.05.1887  0.732
2011 Correia S, Casadesus G, LaManna J, Perry G, Zhu X, Smith M, Moreira P. P3-290: Neuroprotective effects of hypoxic preconditioning on streptozotocin-induced animal model of sporadic Alzheimer's disease Alzheimer's & Dementia. 7: S609-S609. DOI: 10.1016/J.Jalz.2011.05.1732  0.778
2011 Correia S, Perry G, Zhu X, Smith M, Moreira P. P3-146: Decline in mitochondrial bioenergetics underlies central insulin resistance in streptozocin-induced model of sporadic Alzheimer's disease Alzheimer's & Dementia. 7: S562-S562. DOI: 10.1016/J.Jalz.2011.05.1586  0.816
2011 Kudo W, Lee H, Zhu X, Smith M, Lee H. P2-299: Cell cycle aberrations mediate neurotoxicity induced by soluble amyloid-beta oligomers Alzheimer's & Dementia. 7: S406-S406. DOI: 10.1016/J.Jalz.2011.05.1177  0.801
2011 Nair N, Kudo W, Smith MA, Abrol R, Goddard WA, Reddy VP. Corrigendum to “Novel purine-based fluoroaryl-1,2,3-triazoles as neuroprotecting agents: Synthesis, neuronal cell culture investigations, and CDK5 docking studies” [Bioorg. Med. Chem. Lett. 11 (2001) 3165–3168] Bioorganic & Medicinal Chemistry Letters. 21: 5649. DOI: 10.1016/J.Bmcl.2011.07.014  0.784
2010 Clark TA, Lee HP, Rolston RK, Zhu X, Marlatt MW, Castellani RJ, Nunomura A, Casadesus G, Smith MA, Lee HG, Perry G. Oxidative Stress and its Implications for Future Treatments and Management of Alzheimer Disease. International Journal of Biomedical Science : Ijbs. 6: 225-227. PMID 21765811  0.857
2010 Dwyer BE, Zacharski LR, Balestra DJ, Lerner AJ, Perry G, Zhu X, Smith MA. Potential role of iron in a Mediterranean-style diet. Archives of Neurology. 67: 1286-7; author reply. PMID 20937965 DOI: 10.1001/archneurol.2010.245  0.761
2010 Borghi R, Piccini A, Barini E, Cirmena G, Guglielmotto M, Tamagno E, Fornaro M, Perry G, Smith MA, Garuti A, Tabaton M. Upregulation of presenilin 1 in brains of sporadic, late-onset Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 22: 771-5. PMID 20847436 DOI: 10.3233/Jad-2010-100729  0.817
2010 Correia SC, Carvalho C, Cardoso S, Santos RX, Santos MS, Oliveira CR, Perry G, Zhu X, Smith MA, Moreira PI. Mitochondrial preconditioning: a potential neuroprotective strategy. Frontiers in Aging Neuroscience. 2. PMID 20838473 DOI: 10.3389/Fnagi.2010.00138  0.815
2010 Castellani RJ, Rolston RK, Smith MA. Alzheimer disease. Disease-a-Month : Dm. 56: 484-546. PMID 20831921 DOI: 10.1016/j.disamonth.2010.06.001  0.851
2010 Zivković L, Spremo-Potparević B, Plecas-Solarović B, Djelić N, Ocić G, Smiljković P, Siedlak SL, Smith MA, Bajić V. Premature centromere division of metaphase chromosomes in peripheral blood lymphocytes of Alzheimer's disease patients: relation to gender and age. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 65: 1269-74. PMID 20805239 DOI: 10.1093/Gerona/Glq148  0.606
2010 Buxton GA, Siedlak SL, Perry G, Smith MA. Mathematical modeling of microtubule dynamics: insights into physiology and disease. Progress in Neurobiology. 92: 478-83. PMID 20713128 DOI: 10.1016/J.Pneurobio.2010.08.003  0.71
2010 Bonda DJ, Mailankot M, Stone JG, Garrett MR, Staniszewska M, Castellani RJ, Siedlak SL, Zhu X, Lee HG, Perry G, Nagaraj RH, Smith MA. Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease. Redox Report : Communications in Free Radical Research. 15: 161-8. PMID 20663292 DOI: 10.1179/174329210X12650506623645  0.876
2010 Santos RX, Correia SC, Wang X, Perry G, Smith MA, Moreira PI, Zhu X. Alzheimer's disease: diverse aspects of mitochondrial malfunctioning. International Journal of Clinical and Experimental Pathology. 3: 570-81. PMID 20661404  0.845
2010 Storace D, Cammarata S, Borghi R, Sanguineti R, Giliberto L, Piccini A, Pollero V, Novello C, Caltagirone C, Smith MA, Bossù P, Perry G, Odetti P, Tabaton M. Elevation of {beta}-amyloid 1-42 autoantibodies in the blood of amnestic patients with mild cognitive impairment. Archives of Neurology. 67: 867-72. PMID 20625095 DOI: 10.1001/Archneurol.2010.137  0.798
2010 Moreira PI, Santos RX, Zhu X, Lee HG, Smith MA, Casadesus G, Perry G. Autophagy in Alzheimer's disease. Expert Review of Neurotherapeutics. 10: 1209-18. PMID 20586699 DOI: 10.1586/Ern.10.84  0.873
2010 Lee HP, Zhu X, Casadesus G, Castellani RJ, Nunomura A, Smith MA, Lee HG, Perry G. Antioxidant approaches for the treatment of Alzheimer's disease. Expert Review of Neurotherapeutics. 10: 1201-8. PMID 20586698 DOI: 10.1586/ern.10.74  0.85
2010 Bonda DJ, Lee HP, Kudo W, Zhu X, Smith MA, Lee HG. Pathological implications of cell cycle re-entry in Alzheimer disease. Expert Reviews in Molecular Medicine. 12: e19. PMID 20584423 DOI: 10.1017/S146239941000150X  0.85
2010 Moh CF, Siedlak SL, Tabaton M, Perry G, Castellani RJ, Smith MA. Paraffin-embedded tissue (PET) blot method: application to Alzheimer disease. Journal of Neuroscience Methods. 190: 244-7. PMID 20580647 DOI: 10.1016/J.Jneumeth.2010.05.010  0.788
2010 Correia SC, Santos RX, Perry G, Zhu X, Moreira PI, Smith MA. Mitochondria: the missing link between preconditioning and neuroprotection. Journal of Alzheimer's Disease : Jad. 20: S475-85. PMID 20463394 DOI: 10.3233/Jad-2010-100669  0.789
2010 Santos RX, Correia SC, Wang X, Perry G, Smith MA, Moreira PI, Zhu X. A synergistic dysfunction of mitochondrial fission/fusion dynamics and mitophagy in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 20: S401-12. PMID 20463393 DOI: 10.3233/Jad-2010-100666  0.855
2010 Poeggeler B, Sambamurti K, Siedlak SL, Perry G, Smith MA, Pappolla MA. A novel endogenous indole protects rodent mitochondria and extends rotifer lifespan. Plos One. 5: e10206. PMID 20421998 DOI: 10.1371/Journal.Pone.0010206  0.797
2010 Mondragón-Rodríguez S, Basurto-Islas G, Lee HG, Perry G, Zhu X, Castellani RJ, Smith MA. Causes versus effects: the increasing complexities of Alzheimer's disease pathogenesis. Expert Review of Neurotherapeutics. 10: 683-91. PMID 20420489 DOI: 10.1586/Ern.10.27  0.844
2010 Bonda DJ, Wang X, Perry G, Nunomura A, Tabaton M, Zhu X, Smith MA. Oxidative stress in Alzheimer disease: a possibility for prevention. Neuropharmacology. 59: 290-4. PMID 20394761 DOI: 10.1016/J.Neuropharm.2010.04.005  0.869
2010 Gustaw-Rothenberg K, Lerner A, Bonda DJ, Lee HG, Zhu X, Perry G, Smith MA. Biomarkers in Alzheimer's disease: past, present and future. Biomarkers in Medicine. 4: 15-26. PMID 20387301 DOI: 10.2217/bmm.09.86  0.857
2010 Yao C, El Khoury R, Wang W, Byrd TA, Pehek EA, Thacker C, Zhu X, Smith MA, Wilson-Delfosse AL, Chen SG. LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease. Neurobiology of Disease. 40: 73-81. PMID 20382224 DOI: 10.1016/J.Nbd.2010.04.002  0.762
2010 Heath JE, Siedlak SL, Zhu X, Lee HG, Thakur A, Yan R, Perry G, Smith MA, Castellani RJ. Widespread distribution of reticulon-3 in various neurodegenerative diseases. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 30: 574-9. PMID 20374499 DOI: 10.1111/J.1440-1789.2010.01107.X  0.862
2010 Nakamura M, Shishido N, Nunomura A, Smith MA, Perry G, Akutsu H, Hayashi T. Specific reaction of Met 35 in amyloid beta peptide with hypochlorous acid. Free Radical Research. 44: 734-41. PMID 20370566 DOI: 10.3109/10715761003745954  0.789
2010 Lee HP, Zhu X, Liu G, Chen SG, Perry G, Smith MA, Lee HG. Divalent metal transporter, iron, and Parkinson's disease: a pathological relationship. Cell Research. 20: 397-9. PMID 20357807 DOI: 10.1038/Cr.2010.39  0.785
2010 Chang KH, de Pablo Y, Lee HP, Lee HG, Smith MA, Shah K. Cdk5 is a major regulator of p38 cascade: relevance to neurotoxicity in Alzheimer's disease. Journal of Neurochemistry. 113: 1221-9. PMID 20345761 DOI: 10.1111/J.1471-4159.2010.06687.X  0.742
2010 Suszynska J, Tisonczyk J, Lee HG, Smith MA, Jakubowski H. Reduced homocysteine-thiolactonase activity in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 19: 1177-83. PMID 20308784 DOI: 10.3233/JAD-2010-1311  0.752
2010 Greco SJ, Bryan KJ, Sarkar S, Zhu X, Smith MA, Ashford JW, Johnston JM, Tezapsidis N, Casadesus G. Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 19: 1155-67. PMID 20308782 DOI: 10.3233/Jad-2010-1308  0.83
2010 Bonda DJ, Wang X, Perry G, Smith MA, Zhu X. Mitochondrial dynamics in Alzheimer's disease: opportunities for future treatment strategies. Drugs & Aging. 27: 181-92. PMID 20210366 DOI: 10.2165/11532140-000000000-00000  0.847
2010 Bonda DJ, Lee HP, Lee HG, Friedlich AL, Perry G, Zhu X, Smith MA. Novel therapeutics for Alzheimer's disease: an update. Current Opinion in Drug Discovery & Development. 13: 235-46. PMID 20205057  0.858
2010 Nair NG, Perry G, Smith MA, Reddy VP. NMR studies of zinc, copper, and iron binding to histidine, the principal metal ion complexing site of amyloid-beta peptide. Journal of Alzheimer's Disease : Jad. 20: 57-66. PMID 20164601 DOI: 10.3233/JAD-2010-1346  0.577
2010 Wang X, Perry G, Smith MA, Zhu X. Amyloid-beta-derived diffusible ligands cause impaired axonal transport of mitochondria in neurons. Neuro-Degenerative Diseases. 7: 56-9. PMID 20160460 DOI: 10.1159/000283484  0.828
2010 Su B, Wang X, Bonda D, Perry G, Smith M, Zhu X. Abnormal mitochondrial dynamics--a novel therapeutic target for Alzheimer's disease? Molecular Neurobiology. 41: 87-96. PMID 20101529 DOI: 10.1007/S12035-009-8095-7  0.823
2010 Smith MA, Zhu X, Tabaton M, Liu G, McKeel DW, Cohen ML, Wang X, Siedlak SL, Dwyer BE, Hayashi T, Nakamura M, Nunomura A, Perry G. Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment. Journal of Alzheimer's Disease : Jad. 19: 363-72. PMID 20061651 DOI: 10.3233/Jad-2010-1239  0.83
2010 Del Valle J, Duran-Vilaregut J, Manich G, Casadesús G, Smith MA, Camins A, Pallàs M, Pelegrí C, Vilaplana J. Early amyloid accumulation in the hippocampus of SAMP8 mice. Journal of Alzheimer's Disease : Jad. 19: 1303-15. PMID 20061609 DOI: 10.3233/JAD-2010-1321  0.388
2010 Bonda DJ, Bajić VP, Spremo-Potparevic B, Casadesus G, Zhu X, Smith MA, Lee HG. Review: cell cycle aberrations and neurodegeneration. Neuropathology and Applied Neurobiology. 36: 157-63. PMID 20059701 DOI: 10.1111/J.1365-2990.2010.01064.X  0.85
2010 Valdez CM, Smith MA, Perry G, Phelix CF, Santamaria F. Cholesterol homeostasis markers are localized to mouse hippocampal pyramidal and granule layers. Hippocampus. 20: 902-5. PMID 20054815 DOI: 10.1002/hipo.20743  0.606
2010 Nunomura A, Tamaoki T, Tanaka K, Motohashi N, Nakamura M, Hayashi T, Yamaguchi H, Shimohama S, Lee HG, Zhu X, Smith MA, Perry G. Intraneuronal amyloid beta accumulation and oxidative damage to nucleic acids in Alzheimer disease. Neurobiology of Disease. 37: 731-7. PMID 20034567 DOI: 10.1016/J.Nbd.2009.12.012  0.852
2010 Tabaton M, Perry G, Zhu X, Lee HG, Casadesus G, Smith MA. Memantine: "hypothesis testing" not "disease modifying" in Alzheimer's disease. The American Journal of Pathology. 176: 540-1. PMID 20019185 DOI: 10.2353/ajpath.2010.090856  0.836
2010 Moreira PI, Sayre LM, Zhu X, Nunomura A, Smith MA, Perry G. Detection and localization of markers of oxidative stress by in situ methods: application in the study of Alzheimer disease. Methods in Molecular Biology (Clifton, N.J.). 610: 419-34. PMID 20013193 DOI: 10.1007/978-1-60327-029-8_25  0.824
2010 Liu G, Men P, Perry G, Smith MA. Nanoparticle and iron chelators as a potential novel Alzheimer therapy. Methods in Molecular Biology (Clifton, N.J.). 610: 123-44. PMID 20013176 DOI: 10.1007/978-1-60327-029-8_8  0.672
2010 Bryan KJ, Mudd JC, Richardson SL, Chang J, Lee HG, Zhu X, Smith MA, Casadesus G. Down-regulation of serum gonadotropins is as effective as estrogen replacement at improving menopause-associated cognitive deficits. Journal of Neurochemistry. 112: 870-81. PMID 19943850 DOI: 10.1111/J.1471-4159.2009.06502.X  0.778
2010 Su B, Wang X, Lee HG, Tabaton M, Perry G, Smith MA, Zhu X. Chronic oxidative stress causes increased tau phosphorylation in M17 neuroblastoma cells. Neuroscience Letters. 468: 267-71. PMID 19914335 DOI: 10.1016/J.Neulet.2009.11.010  0.836
2010 Moreira PI, Carvalho C, Zhu X, Smith MA, Perry G. Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology. Biochimica Et Biophysica Acta. 1802: 2-10. PMID 19853658 DOI: 10.1016/j.bbadis.2009.10.006  0.85
2010 Moreira PI, Zhu X, Wang X, Lee HG, Nunomura A, Petersen RB, Perry G, Smith MA. Mitochondria: a therapeutic target in neurodegeneration. Biochimica Et Biophysica Acta. 1802: 212-20. PMID 19853657 DOI: 10.1016/J.Bbadis.2009.10.007  0.826
2010 Gustaw-Rothenberg KA, Siedlak SL, Bonda DJ, Lerner A, Tabaton M, Perry G, Smith MA. Dissociated amyloid-beta antibody levels as a serum biomarker for the progression of Alzheimer's disease: a population-based study. Experimental Gerontology. 45: 47-52. PMID 19819324 DOI: 10.1016/J.Exger.2009.10.003  0.84
2010 Su B, Wang X, Zheng L, Perry G, Smith MA, Zhu X. Abnormal mitochondrial dynamics and neurodegenerative diseases. Biochimica Et Biophysica Acta. 1802: 135-42. PMID 19799998 DOI: 10.1016/J.Bbadis.2009.09.013  0.813
2010 Kaminsky YG, Marlatt MW, Smith MA, Kosenko EA. Subcellular and metabolic examination of amyloid-beta peptides in Alzheimer disease pathogenesis: evidence for Abeta(25-35). Experimental Neurology. 221: 26-37. PMID 19751725 DOI: 10.1016/j.expneurol.2009.09.005  0.83
2010 Tabaton M, Zhu X, Perry G, Smith MA, Giliberto L. Signaling effect of amyloid-beta(42) on the processing of AbetaPP. Experimental Neurology. 221: 18-25. PMID 19747481 DOI: 10.1016/j.expneurol.2009.09.002  0.83
2010 Smith MA, Perry G, Zhu X, Haoudi A. Neurodegenerative diseases: mechanisms and therapies. Journal of Biomedicine & Biotechnology. 2006: 47539. PMID 17047307 DOI: 10.1155/JBB/2006/47539  0.825
2010 Zhu X, Beal MF, Wang X, Perry G, Smith MA. Preface: Mitochondria and neurodegenerative diseases Journal of Alzheimer's Disease. 20: S253. DOI: 10.3233/Jad-2010-1424  0.812
2010 Smith M, Zhu X, Lee H, Castellani R, Perry G. The Importance of Histochemical Detection of Oxidative Damage in Tissue Microscopy and Microanalysis. 16: 1016-1017. DOI: 10.1017/S1431927610059866  0.784
2010 Bajic VP, Spremo-Potparevic B, Zivkovic L, Siedlak S, Smith MA. RAD 21 cohesion protein shows altered levels of expression in the Swedish mutant phenotype of M17 neuroblastoma cells Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.840  0.689
2010 Kudo W, Zhu X, Bajić VP, Lee H, Smith MA. P1-287: Neuronal cell cycle re-entry as a neurotoxic mechanism of soluble amyloid oligomers in hippocampal slice cultures Alzheimer's & Dementia. 6: S257-S257. DOI: 10.1016/J.Jalz.2010.05.839  0.806
2010 Stone J, Bonda D, Lee H, Richardson S, Casadesus G, Smith MA. P1-200: Association of leptin receptor with neurofibrillary tangles of Alzheimer disease Alzheimer's & Dementia. 6: S231-S231. DOI: 10.1016/J.Jalz.2010.05.750  0.827
2010 Shenk JC, Smith MA, Castellani RJ, Moreira P, Aliev G, Siedlak SL, Harris PL, Sayre L, Szweda PA, Szweda LI, Perry G. P1-196: Lipid peroxidation markers are associated with granulovacuolar degeneration but not lipofuscin formation Alzheimer's & Dementia. 6: S230-S230. DOI: 10.1016/J.Jalz.2010.05.746  0.774
2010 Zhu X, Wang X, Su B, Protter A, Perry G, Smith MA. P3-459: Latrepirdine (Dimebon™) modulate mitochondrial dynamics in AD cell models Alzheimer's & Dementia. 6: S588-S588. DOI: 10.1016/J.Jalz.2010.05.2002  0.803
2010 Gustaw-Rothenberg KA, Friedland RP, Dmoszynska M, Siedlak SL, Smith MA. Transthyretin and Aβ in Alzheimer's disease Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.1719  0.769
2010 Gustaw-Rothenberg KA, Siedlak SL, Perry G, Lerner A, Smith MA. P3-208: Total antioxidant status in newly diagnosed Alzheimer's patients: Population based study Alzheimer's & Dementia. 6: S512-S512. DOI: 10.1016/J.Jalz.2010.05.1707  0.718
2010 Gustaw-Rothenberg KA, Lerner A, Perry G, Siedlak SL, Zhu X, Smith MA. P3-204: MDA and GSH levels in newly diagnosed Alzheimer's disease patients: A population-based study Alzheimer's & Dementia. 6: S510-S511. DOI: 10.1016/J.Jalz.2010.05.1703  0.821
2010 Lee H, Lee H, Kudo W, Zhu X, Perry G, Smith MA. P2-316: Disturbance in AMP-activated protein kinase (AMPK) signaling pathway in Alzheimer's disease Alzheimer's & Dementia. 6: S406-S406. DOI: 10.1016/J.Jalz.2010.05.1367  0.815
2010 Lee H, Siedlak SL, Zhu X, Smith MA, Lee H. P2-300: Abnormal activation of protein kinase C theta in Alzheimer's disease: Pathological implications Alzheimer's & Dementia. 6: S401-S401. DOI: 10.1016/J.Jalz.2010.05.1350  0.828
2010 Prakash Reddy V, Perry G, Smith MA. Brain composition: Age-related changes Encyclopedia of Neuroscience. 313-316. DOI: 10.1016/B978-008045046-9.00108-X  0.502
2009 Cardoso S, Santos R, Correia S, Carvalho C, Zhu X, Lee HG, Casadesus G, Smith MA, Perry G, Moreira PI. Insulin and Insulin-Sensitizing Drugs in Neurodegeneration: Mitochondria as Therapeutic Targets. Pharmaceuticals (Basel, Switzerland). 2: 250-286. PMID 27713238 DOI: 10.3390/Ph2030250  0.787
2009 Rolston RK, Perry G, Zhu X, Castellani RJ, Dwyer BE, Lee HG, Petersen RB, Smith MA. Iron: A Pathological Mediator of Alzheimer Disease? Agro Food Industry Hi-Tech. 19: 33-36. PMID 21544251  0.857
2009 Friedlich AL, Rolston RK, Zhu X, Marlatt MW, Castellani RJ, Nunomura A, Lee HG, Casadesus G, Perry G, Smith MA. Treatment advances in Alzheimer's disease based on the oxidative stress model. F1000 Medicine Reports. 1. PMID 20948726 DOI: 10.3410/M1-54  0.872
2009 Bonda DJ, Wang X, Gustaw-Rothenberg KA, Perry G, Smith MA, Zhu X. Mitochondrial Drugs for Alzheimer Disease. Pharmaceuticals (Basel, Switzerland). 2: 287-298. PMID 20657666 DOI: 10.3390/Ph2030287  0.871
2009 Liu G, Men P, Perry G, Smith MA. Chapter 5 - Development of iron chelator-nanoparticle conjugates as potential therapeutic agents for Alzheimer disease. Progress in Brain Research. 180: 97-108. PMID 20302830 DOI: 10.1016/S0079-6123(08)80005-2  0.662
2009 Greco SJ, Bryan KJ, Sarkar S, Zhu X, Smith MA, Ashford JW, Johnston JM, Tezapsidis N, Casadesus G. Chronic Leptin Supplementation Ameliorates Pathology and Improves Cognitive Performance in a Transgenic Mouse Model of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 20009219 DOI: 10.3233/JAD-2009-1308  0.831
2009 Perry G, Moreira PI, Siedlak SL, Nunomura A, Zhu X, Smith MA. Natural oxidant balance in Parkinson disease. Archives of Neurology. 66: 1445. PMID 20008647 DOI: 10.1001/Archneurol.2009.261  0.825
2009 Bonda DJ, Evans TA, Santocanale C, Llosá JC, Viña J, Bajic V, Castellani RJ, Siedlak SL, Perry G, Smith MA, Lee HG. Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease. Aging. 1: 382-8. PMID 19946466 DOI: 10.18632/AGING.100044  0.858
2009 Liu G, Men P, Perry G, Smith MA. Metal chelators coupled with nanoparticles as potential therapeutic agents for Alzheimer's disease. Journal of Nanoneuroscience. 1: 42-55. PMID 19936278 DOI: 10.1166/JNS.2009.005  0.642
2009 Lee HP, Casadesus G, Zhu X, Lee HG, Perry G, Smith MA, Gustaw-Rothenberg K, Lerner A. All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease. Expert Review of Neurotherapeutics. 9: 1615-21. PMID 19903021 DOI: 10.1586/ern.09.86  0.838
2009 Snape M, Lee HG, Casadesus G, Smith MA. Cell cycle aberrations in Alzheimer's disease: a novel therapeutic opportunity. Expert Review of Neurotherapeutics. 9: 1579-80. PMID 19903017 DOI: 10.1586/ern.09.113  0.84
2009 Carvalho C, Correia SC, Santos RX, Cardoso S, Moreira PI, Clark TA, Zhu X, Smith MA, Perry G. Role of mitochondrial-mediated signaling pathways in Alzheimer disease and hypoxia. Journal of Bioenergetics and Biomembranes. 41: 433-40. PMID 19830532 DOI: 10.1007/S10863-009-9247-1  0.835
2009 McShea A, Leissle K, Smith MA. The essence of chocolate: a rich, dark, and well-kept secret. Nutrition (Burbank, Los Angeles County, Calif.). 25: 1104-5. PMID 19818278 DOI: 10.1016/j.nut.2009.05.012  0.652
2009 Lee HG, Chen Q, Wolfram JA, Richardson SL, Liner A, Siedlak SL, Zhu X, Ziats NP, Fujioka H, Felsher DW, Castellani RJ, Valencik ML, McDonald JA, Hoit BD, Lesnefsky EJ, ... Smith MA, et al. Cell cycle re-entry and mitochondrial defects in myc-mediated hypertrophic cardiomyopathy and heart failure. Plos One. 4: e7172. PMID 19779629 DOI: 10.1371/Journal.Pone.0007172  0.784
2009 Sun KH, Lee HG, Smith MA, Shah K. Direct and indirect roles of cyclin-dependent kinase 5 as an upstream regulator in the c-Jun NH2-terminal kinase cascade: relevance to neurotoxic insults in Alzheimer's disease. Molecular Biology of the Cell. 20: 4611-9. PMID 19776350 DOI: 10.1091/Mbc.E09-05-0433  0.711
2009 Smith MA, Casadesus G. Walking toward a convergence in aging research. Frontiers in Neuroscience. 3: 1. PMID 19753087 DOI: 10.3389/neuro.01.012.2009  0.696
2009 Arif M, Chikuma T, Ahmed MM, Nakazato M, Smith MA, Kato T. Effects of memantine on soluble Αβ25-35-induced changes in peptidergic and glial cells in Alzheimer's disease model rat brain regions Neuroscience. 164: 1199-1209. PMID 19733635 DOI: 10.1016/j.neuroscience.2009.08.063  0.496
2009 Bajić VP, Spremo-Potparević B, Zivković L, Bonda DJ, Siedlak SL, Casadesus G, Lee HG, Smith MA. The X-chromosome instability phenotype in Alzheimer's disease: a clinical sign of accelerating aging? Medical Hypotheses. 73: 917-20. PMID 19647374 DOI: 10.1016/J.Mehy.2009.06.046  0.826
2009 Su B, Liu H, Wang X, Chen SG, Siedlak SL, Kondo E, Choi R, Takeda A, Castellani RJ, Perry G, Smith MA, Zhu X, Lee HG. Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease. Molecular Neurodegeneration. 4: 32. PMID 19627592 DOI: 10.1186/1750-1326-4-32  0.801
2009 Wang X, Su B, Lee HG, Li X, Perry G, Smith MA, Zhu X. Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 9090-103. PMID 19605646 DOI: 10.1523/Jneurosci.1357-09.2009  0.824
2009 Smith MA, Perry G. Commentary on "Perspective on a pathogenesis and treatment of Alzheimer's disease." Therapeutic strategies for Alzheimer's disease: the need for a new era of innovation. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 2: 294-5. PMID 19595903 DOI: 10.1016/j.jalz.2006.07.002  0.691
2009 Castellani RJ, Lee HG, Siedlak SL, Nunomura A, Hayashi T, Nakamura M, Zhu X, Perry G, Smith MA. Reexamining Alzheimer's disease: evidence for a protective role for amyloid-beta protein precursor and amyloid-beta. Journal of Alzheimer's Disease : Jad. 18: 447-52. PMID 19584435 DOI: 10.3233/Jad-2009-1151  0.851
2009 Cardoso S, Correia S, Santos RX, Carvalho C, Santos MS, Oliveira CR, Perry G, Smith MA, Zhu X, Moreira PI. Insulin is a two-edged knife on the brain. Journal of Alzheimer's Disease : Jad. 18: 483-507. PMID 19542630 DOI: 10.3233/Jad-2009-1155  0.782
2009 Dwyer BE, Stone ML, Gorman N, Sinclair PR, Perry G, Smith MA, Zhu X. Heme-a, the heme prosthetic group of cytochrome c oxidase, is increased in Alzheimer's disease. Neuroscience Letters. 461: 302-5. PMID 19539709 DOI: 10.1016/j.neulet.2009.06.007  0.834
2009 Barbeito AG, Garringer HJ, Baraibar MA, Gao X, Arredondo M, Núñez MT, Smith MA, Ghetti B, Vidal R. Abnormal iron metabolism and oxidative stress in mice expressing a mutant form of the ferritin light polypeptide gene. Journal of Neurochemistry. 109: 1067-78. PMID 19519778 DOI: 10.1111/J.1471-4159.2009.06028.X  0.314
2009 Dwyer BE, Smith MA, Richardson SL, Perry G, Zhu X. Down-regulation of aminolevulinate synthase, the rate-limiting enzyme for heme biosynthesis in Alzheimer's disease. Neuroscience Letters. 460: 180-4. PMID 19477221 DOI: 10.1016/j.neulet.2009.05.058  0.814
2009 Perez M, Santa-Maria I, Gomez de Barreda E, Zhu X, Cuadros R, Cabrero JR, Sanchez-Madrid F, Dawson HN, Vitek MP, Perry G, Smith MA, Avila J. Tau--an inhibitor of deacetylase HDAC6 function. Journal of Neurochemistry. 109: 1756-66. PMID 19457097 DOI: 10.1111/J.1471-4159.2009.06102.X  0.811
2009 Greco SJ, Sarkar S, Casadesus G, Zhu X, Smith MA, Ashford JW, Johnston JM, Tezapsidis N. Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells. Neuroscience Letters. 455: 191-4. PMID 19429119 DOI: 10.1016/J.Neulet.2009.03.066  0.824
2009 Liu G, Men P, Kudo W, Perry G, Smith MA. Nanoparticle-chelator conjugates as inhibitors of amyloid-beta aggregation and neurotoxicity: a novel therapeutic approach for Alzheimer disease. Neuroscience Letters. 455: 187-90. PMID 19429118 DOI: 10.1016/J.Neulet.2009.03.064  0.835
2009 Casley CS, Lakics V, Lee HG, Broad LM, Day TA, Cluett T, Smith MA, O'Neill MJ, Kingston AE. Up-regulation of astrocyte metabotropic glutamate receptor 5 by amyloid-β peptide. Brain Research. 1260: 65-75. PMID 19401173 DOI: 10.1016/j.brainres.2008.12.082  0.711
2009 Castellani RJ, Zhu X, Lee HG, Smith MA, Perry G. Molecular pathogenesis of Alzheimer's disease: reductionist versus expansionist approaches. International Journal of Molecular Sciences. 10: 1386-406. PMID 19399255 DOI: 10.3390/ijms10031386  0.854
2009 Wang X, Su B, Zheng L, Perry G, Smith MA, Zhu X. The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease. Journal of Neurochemistry. 109: 153-9. PMID 19393022 DOI: 10.1111/J.1471-4159.2009.05867.X  0.818
2009 Reddy VP, Zhu X, Perry G, Smith MA. Oxidative stress in diabetes and Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 16: 763-74. PMID 19387111 DOI: 10.3233/JAD-2009-1013  0.832
2009 Tezapsidis N, Johnston JM, Smith MA, Ashford JW, Casadesus G, Robakis NK, Wolozin B, Perry G, Zhu X, Greco SJ, Sarkar S. Leptin: a novel therapeutic strategy for Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 16: 731-40. PMID 19387109 DOI: 10.3233/Jad-2009-1021  0.849
2009 Smith MA, Rolston RK. Foodborne and microbial toxins, part I: Chemical contamination and additives. Foreword. Disease-a-Month : Dm. 55: 261-2. PMID 19362175 DOI: 10.1016/j.disamonth.2009.03.001  0.691
2009 Yeste-Velasco M, Folch J, Casadesús G, Smith MA, Pallàs M, Camins A. Neuroprotection by c-Jun NH2-terminal kinase inhibitor SP600125 against potassium deprivation-induced apoptosis involves the Akt pathway and inhibition of cell cycle reentry. Neuroscience. 159: 1135-47. PMID 19356694 DOI: 10.1016/j.neuroscience.2009.01.035  0.303
2009 Pallàs M, Casadesús G, Smith MA, Coto-Montes A, Pelegri C, Vilaplana J, Camins A. Resveratrol and neurodegenerative diseases: activation of SIRT1 as the potential pathway towards neuroprotection. Current Neurovascular Research. 6: 70-81. PMID 19355928 DOI: 10.2174/156720209787466019  0.394
2009 Obrenovich ME, Morales LA, Cobb CJ, Shenk JC, Méndez GM, Fischbach K, Smith MA, Qasimov EK, Perry G, Aliev G. Insights into cerebrovascular complications and Alzheimer disease through the selective loss of GRK2 regulation. Journal of Cellular and Molecular Medicine. 13: 853-65. PMID 19292735 DOI: 10.1111/J.1582-4934.2008.00512.X  0.843
2009 Boyd JL, Casson I, DeKosky S, Feuer H, Gandy S, Khachaturian Z, Kinoshita J, Marchesi V, McKee A, Nowinski C, Perl D, Purohit D, Relkin N, Smith MA, Strobel G, et al. Alzheimer research forum live discussion: Sports concussions, dementia, and ApoE genotyping: What can scientists tell the public? What's up for research? Journal of Alzheimer's Disease. 16: 657-666. PMID 19276560 DOI: 10.3233/Jad-2009-1014  0.33
2009 Nunomura A, Hofer T, Moreira PI, Castellani RJ, Smith MA, Perry G. RNA oxidation in Alzheimer disease and related neurodegenerative disorders. Acta Neuropathologica. 118: 151-66. PMID 19271225 DOI: 10.1007/s00401-009-0508-1  0.808
2009 Perry G, Zhu X, Moreira PI, Smith MA. Altered redox balance in disease: can we change the new equilibria? Annals of Neurology. 65: 121-3. PMID 19259960 DOI: 10.1002/ana.21608  0.808
2009 Rajendran R, Minqin R, Ynsa MD, Casadesus G, Smith MA, Perry G, Halliwell B, Watt F. A novel approach to the identification and quantitative elemental analysis of amyloid deposits--insights into the pathology of Alzheimer's disease. Biochemical and Biophysical Research Communications. 382: 91-5. PMID 19258010 DOI: 10.1016/j.bbrc.2009.02.136  0.794
2009 Guglielmotto M, Aragno M, Autelli R, Giliberto L, Novo E, Colombatto S, Danni O, Parola M, Smith MA, Perry G, Tamagno E, Tabaton M. The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1alpha. Journal of Neurochemistry. 108: 1045-56. PMID 19196431 DOI: 10.1111/j.1471-4159.2008.05858.x  0.793
2009 Dwyer BE, Zacharski LR, Balestra DJ, Lerner AJ, Perry G, Zhu X, Smith MA. Getting the iron out: phlebotomy for Alzheimer's disease? Medical Hypotheses. 72: 504-9. PMID 19195795 DOI: 10.1016/j.mehy.2008.12.029  0.827
2009 Lee HP, Zhu X, Zhu X, Skidmore SC, Perry G, Sayre LM, Smith MA, Lee HG. The essential role of ERK in 4-oxo-2-nonenal-mediated cytotoxicity in SH-SY5Y human neuroblastoma cells. Journal of Neurochemistry. 108: 1434-41. PMID 19183271 DOI: 10.1111/J.1471-4159.2009.05883.X  0.787
2009 Lee HG, Casadesus G, Nunomura A, Zhu X, Castellani RJ, Richardson SL, Perry G, Felsher DW, Petersen RB, Smith MA. The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse. The American Journal of Pathology. 174: 891-7. PMID 19164506 DOI: 10.2353/Ajpath.2009.080583  0.832
2009 Tajes M, Yeste-Velasco M, Zhu X, Chou SP, Smith MA, Pallàs M, Camins A, Casadesús G. Activation of Akt by lithium: pro-survival pathways in aging. Mechanisms of Ageing and Development. 130: 253-61. PMID 19162061 DOI: 10.1016/j.mad.2008.12.006  0.736
2009 Siedlak SL, Casadesus G, Webber KM, Pappolla MA, Atwood CS, Smith MA, Perry G. Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease. Free Radical Research. 43: 156-64. PMID 19160110 DOI: 10.1080/10715760802644694  0.834
2009 Lee HG, Casadesus G, Zhu X, Castellani RJ, McShea A, Perry G, Petersen RB, Bajic V, Smith MA. Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease. Neurochemistry International. 54: 84-8. PMID 19114068 DOI: 10.1016/J.Neuint.2008.10.013  0.867
2009 Stone JG, Rolston RK, Ueda M, Lee HG, Richardson SL, Castellani RJ, Perry G, Smith MA. Evidence for the novel expression of human kallikrein-related peptidase 3, prostate-specific antigen, in the brain. International Journal of Clinical and Experimental Pathology. 2: 267-74. PMID 19079621  0.783
2009 Ramiro-Puig E, Casadesús G, Lee HG, Zhu X, McShea A, Perry G, Pérez-Cano FJ, Smith MA, Castell M. Neuroprotective effect of cocoa flavonoids on in vitro oxidative stress. European Journal of Nutrition. 48: 54-61. PMID 19043659 DOI: 10.1007/s00394-008-0761-4  0.798
2009 Lee HG, Zhu X, Casadesus G, Pallàs M, Camins A, O'Neill MJ, Nakanishi S, Perry G, Smith MA. The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival. Brain Research. 1249: 244-50. PMID 19026996 DOI: 10.1016/j.brainres.2008.10.055  0.831
2009 Aliev G, Liu J, Shenk JC, Fischbach K, Pacheco GJ, Chen SG, Obrenovich ME, Ward WF, Richardson AG, Smith MA, Gasimov E, Perry G, Ames BN. Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats. Journal of Cellular and Molecular Medicine. 13: 320-33. PMID 18373733 DOI: 10.1111/J.1582-4934.2008.00324.X  0.794
2009 Friedlich AL, Smith MA, Zhu X, Takeda A, Nunomura A, Moreira PI, Perry G. Oxidative Stress in Parkinson`s Disease The Open Pathology Journal. 3: 38-42. DOI: 10.2174/1874375700903010038  0.828
2009 Castellani RJ, Perry G, Smith MA. Is Alzheimer's disease a myth? When is disease a disease? Current Alzheimer Research. 6: 82. DOI: 10.2174/156720509787313925  0.808
2009 Aliev G, Shenk J, Liu J, Puchowicz M, Xu K, Smith M, Siedlak S, Obrenovich M, Ames B, de la Torre J, Koistinaho J, LaManna J, Perry G. Preventative effect of mitochondrial antioxidants in apoe deficiency mouse model of brain hypoperfusion Journal of the Neurological Sciences. 283: 272. DOI: 10.1016/J.Jns.2009.02.126  0.793
2009 Spremo-Potparevic B, Zivkovic L, Djelic N, Plecas-Solarevic B, Smith MA, Bajic V. X chromosome premature centromere division in neurons of Alzheimer patients Alzheimers & Dementia. 5: 485. DOI: 10.1016/J.Jalz.2009.04.749  0.633
2009 Shenk JC, Castellani RJ, Moreira P, Aliev G, Siedlak SL, Harris PL, Sayre L, Szweda PA, Smith MA, Perry G. P2-186: Hydroxynonenal generated crosslinking fluorophores accumulate in Alzheimer's disease Alzheimer's & Dementia. 5: P315-P315. DOI: 10.1016/J.Jalz.2009.04.498  0.837
2009 Bajic VP, Spremo-Potparevic B, Ilievski D, Zivkovic L, Zhu X, Smith MA. Astrin, a substrate of GSK3β is differentially expressed in AD compared to age-matched controls Alzheimers & Dementia. 5: 311. DOI: 10.1016/J.Jalz.2009.04.484  0.798
2009 Bajic VP, Siedlak S, Smith MA, Milicevic Z, Zivkovic L, Spremo-Potparevic B. CDK11/pitslre protein kinase is differentially expressed in hippocampus of Alzheimer patients Alzheimers & Dementia. 5: 311. DOI: 10.1016/J.Jalz.2009.04.483  0.727
2009 Gustaw-Rothenberg K, Siedlak SL, Lee H, Castellani RJ, Zhu X, Perry G, Petersen RB, Friedland RP, Lerner AJ, Smith MA. P3-073: Dissociated Aβ antibody level in newly diagnosed Alzheimer's disease: A population-based study Alzheimer's & Dementia. 5: P363-P363. DOI: 10.1016/J.Jalz.2009.04.1149  0.836
2009 Ramiro-Puig E, Casadesús G, Lee HG, Zhu X, McShea A, Perry G, Pérez-Cano FJ, Smith MA, Castell M. Neuroprotective effect of cocoa flavonoids on in vitro oxidative stress (European Journal of Nutrition (2008)) European Journal of Nutrition. 48: 61. DOI: 10.1007/s00394-008-0766-z  0.796
2008 Myung NH, Zhu X, Kruman II, Castellani RJ, Petersen RB, Siedlak SL, Perry G, Smith MA, Lee HG. Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes. Age (Dordrecht, Netherlands). 30: 209-15. PMID 19424844 DOI: 10.1007/S11357-008-9050-7  0.831
2008 Castellani RJ, Nunomura A, Rolston RK, Moreira PI, Takeda A, Perry G, Smith MA. Sublethal RNA oxidation as a mechanism for neurodegenerative disease. International Journal of Molecular Sciences. 9: 789-806. PMID 19325784 DOI: 10.3390/Ijms9050789  0.827
2008 Baji? VP, Spremo-Potparevi? B, Zivkovi? L, Djeli? N, Smith MA. Is the time dimension of the cell cycle re-entry in AD regulated by centromere cohesion dynamics? Bioscience Hypotheses. 1: 156-161. PMID 19122823 DOI: 10.1016/J.Bihy.2008.03.006  0.417
2008 Pallas M, Camins A, Smith MA, Perry G, Lee HG, Casadesus G. From aging to Alzheimer's disease: unveiling "the switch" with the senescence-accelerated mouse model (SAMP8). Journal of Alzheimer's Disease : Jad. 15: 615-24. PMID 19096160 DOI: 10.3233/JAD-2008-15408  0.846
2008 Chan HW, Liu T, Verdile G, Bishop G, Haasl RJ, Smith MA, Perry G, Martins RN, Atwood CS. Copper Induces Apoptosis of Neuroblastoma Cells Via Post-translational Regulation of the Expression of Bcl-2-family Proteins and the tx Mouse is a Better Model of Hepatic than Brain Cu Toxicity. International Journal of Clinical and Experimental Medicine. 1: 76-88. PMID 19079689  0.785
2008 Su B, Wang X, Nunomura A, Moreira PI, Lee HG, Perry G, Smith MA, Zhu X. Oxidative stress signaling in Alzheimer's disease. Current Alzheimer Research. 5: 525-32. PMID 19075578 DOI: 10.2174/156720508786898451  0.849
2008 McShea A, Ramiro-Puig E, Munro SB, Casadesus G, Castell M, Smith MA. Clinical benefit and preservation of flavonols in dark chocolate manufacturing. Nutrition Reviews. 66: 630-41. PMID 19019025 DOI: 10.1111/j.1753-4887.2008.00114.x  0.767
2008 Aliev G, Obrenovich ME, Reddy VP, Shenk JC, Moreira PI, Nunomura A, Zhu X, Smith MA, Perry G. Antioxidant therapy in Alzheimer's disease: theory and practice. Mini Reviews in Medicinal Chemistry. 8: 1395-406. PMID 18991755 DOI: 10.2174/138955708786369582  0.837
2008 Marlatt MW, Lucassen PJ, Perry G, Smith MA, Zhu X. Alzheimer's disease: cerebrovascular dysfunction, oxidative stress, and advanced clinical therapies. Journal of Alzheimer's Disease : Jad. 15: 199-210. PMID 18953109 DOI: 10.3233/Jad-2008-15206  0.847
2008 Aliev G, Gasimov E, Obrenovich ME, Fischbach K, Shenk JC, Smith MA, Perry G. Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels: implication in the pathogenesis of Alzheimer's disease. Vascular Health and Risk Management. 4: 721-30. PMID 18827923 DOI: 10.2147/Vhrm.S2608  0.839
2008 Greco SJ, Sarkar S, Johnston JM, Zhu X, Su B, Casadesus G, Ashford JW, Smith MA, Tezapsidis N. Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells. Biochemical and Biophysical Research Communications. 376: 536-41. PMID 18801339 DOI: 10.1016/J.Bbrc.2008.09.026  0.828
2008 Bryan KJ, Zhu X, Harris PL, Perry G, Castellani RJ, Smith MA, Casadesus G. Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease. Molecular Neurodegeneration. 3: 13. PMID 18786268 DOI: 10.1186/1750-1326-3-13  0.841
2008 Perry G, Castellani RJ, Moreira PI, Lee HG, Zhu X, Smith MA. Pathology's new role: defining disease process and protective responses. International Journal of Clinical and Experimental Pathology. 1: 1-4. PMID 18784818  0.817
2008 Thakur A, Siedlak SL, James SL, Bonda DJ, Rao A, Webber KM, Camins A, Pallàs M, Casadesus G, Lee HG, Bowser R, Raina AK, Perry G, Smith MA, Zhu X. Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease. International Journal of Clinical and Experimental Pathology. 1: 134-46. PMID 18784806  0.839
2008 Gelfand SL, Vento M, Sastre J, Lust WD, Smith MA, Perry G, Walsh M, Martin R. A new model of oxidative stress in rat pups. Neonatology. 94: 293-9. PMID 18784426 DOI: 10.1159/000151649  0.569
2008 Castellani RJ, Nunomura A, Lee HG, Perry G, Smith MA. Phosphorylated tau: toxic, protective, or none of the above. Journal of Alzheimer's Disease : Jad. 14: 377-83. PMID 18688087 DOI: 10.3233/JAD-2008-14404  0.842
2008 Spremo-Potparević B, Živković L, Djelić N, Plećaš-Solarović B, Smith MA, Bajić V. Premature centromere division of the X chromosome in neurons in Alzheimer's disease. Journal of Neurochemistry. 106: 2218-2223. PMID 18624923 DOI: 10.1111/J.1471-4159.2008.05555.X  0.694
2008 Collingwood JF, Chong RK, Kasama T, Cervera-Gontard L, Dunin-Borkowski RE, Perry G, Pósfai M, Siedlak SL, Simpson ET, Smith MA, Dobson J. Three-dimensional tomographic imaging and characterization of iron compounds within Alzheimer's plaque core material. Journal of Alzheimer's Disease : Jad. 14: 235-45. PMID 18560134 DOI: 10.3233/Jad-2008-14211  0.728
2008 Tajes M, Gutierrez-Cuesta J, Folch J, Ferrer I, Caballero B, Smith MA, Casadesus G, Camins A, Pallás M. Lithium treatment decreases activities of tau kinases in a murine model of senescence. Journal of Neuropathology and Experimental Neurology. 67: 612-23. PMID 18520779 DOI: 10.1097/NEN.0b013e3181776293  0.735
2008 Castellani RJ, Lee HG, Zhu X, Perry G, Smith MA. Alzheimer disease pathology as a host response. Journal of Neuropathology and Experimental Neurology. 67: 523-31. PMID 18520771 DOI: 10.1097/NEN.0b013e318177eaf4  0.851
2008 Friedland RP, Tedesco JM, Wilson AC, Atwood CS, Smith MA, Perry G, Zagorski MG. Antibodies to potato virus Y bind the amyloid beta peptide: immunohistochemical and NMR studies. The Journal of Biological Chemistry. 283: 22550-6. PMID 18505725 DOI: 10.1074/Jbc.M802088200  0.808
2008 Gustaw KA, Garrett MR, Lee HG, Castellani RJ, Zagorski MG, Prakasam A, Siedlak SL, Zhu X, Perry G, Petersen RB, Friedland RP, Smith MA. Antigen-antibody dissociation in Alzheimer disease: a novel approach to diagnosis. Journal of Neurochemistry. 106: 1350-6. PMID 18485104 DOI: 10.1111/J.1471-4159.2008.05477.X  0.827
2008 Casadesus G, Rolston RK, Webber KM, Atwood CS, Bowen RL, Perry G, Smith MA. Menopause, estrogen, and gonadotropins in Alzheimer's disease. Advances in Clinical Chemistry. 45: 139-53. PMID 18429496 DOI: 10.1016/S0065-2423(07)00006-6  0.855
2008 Shah RS, Lee HG, Xiongwei Z, Perry G, Smith MA, Castellani RJ. Current approaches in the treatment of Alzheimer's disease. Biomedicine & Pharmacotherapy = Biomã©Decine & Pharmacothã©Rapie. 62: 199-207. PMID 18407457 DOI: 10.1016/j.biopha.2008.02.005  0.855
2008 Pizarro JG, Yeste-Velasco M, Rimbau V, Casadesús G, Smith MA, Pallàs M, Folch J, Camins A. Neuroprotective effects of SB-415286 on hydrogen peroxide-induced cell death in B65 rat neuroblastoma cells and neurons. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 26: 269-76. PMID 18342477 DOI: 10.1016/j.ijdevneu.2008.02.002  0.34
2008 Mondragón-Rodríguez S, Basurto-Islas G, Santa-Maria I, Mena R, Binder LI, Avila J, Smith MA, Perry G, García-Sierra F. Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer's disease. International Journal of Experimental Pathology. 89: 81-90. PMID 18336525 DOI: 10.1111/J.1365-2613.2007.00568.X  0.666
2008 Perry G, Zhu X, Babar AK, Siedlak SL, Yang Q, Ito G, Iwatsubo T, Smith MA, Chen SG. Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies. Neuro-Degenerative Diseases. 5: 222-4. PMID 18322396 DOI: 10.1159/000113708  0.822
2008 Moreira PI, Santos MS, Oliveira CR, Shenk JC, Nunomura A, Smith MA, Zhu X, Perry G. Alzheimer disease and the role of free radicals in the pathogenesis of the disease. Cns & Neurological Disorders Drug Targets. 7: 3-10. PMID 18289026 DOI: 10.2174/187152708783885156  0.868
2008 Su B, Wang X, Drew KL, Perry G, Smith MA, Zhu X. Physiological regulation of tau phosphorylation during hibernation. Journal of Neurochemistry. 105: 2098-108. PMID 18284615 DOI: 10.1111/J.1471-4159.2008.05294.X  0.815
2008 Gonzalez-Cuyar LF, Perry G, Miyajima H, Atwood CS, Riveros-Angel M, Lyons PF, Siedlak SL, Smith MA, Castellani RJ. Redox active iron accumulation in aceruloplasminemia. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 28: 466-71. PMID 18282164 DOI: 10.1111/J.1440-1789.2008.00901.X  0.799
2008 Moreira PI, Nunomura A, Nakamura M, Takeda A, Shenk JC, Aliev G, Smith MA, Perry G. Nucleic acid oxidation in Alzheimer disease. Free Radical Biology & Medicine. 44: 1493-505. PMID 18258207 DOI: 10.1016/J.Freeradbiomed.2008.01.002  0.84
2008 Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, ... ... Smith MA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy. 4: 151-75. PMID 18188003 DOI: 10.4161/Auto.5338  0.769
2008 Sayre LM, Perry G, Smith MA. Oxidative stress and neurotoxicity. Chemical Research in Toxicology. 21: 172-88. PMID 18052107 DOI: 10.1021/Tx700210J  0.743
2008 Tamagno E, Guglielmotto M, Aragno M, Borghi R, Autelli R, Giliberto L, Muraca G, Danni O, Zhu X, Smith MA, Perry G, Jo DG, Mattson MP, Tabaton M. Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein. Journal of Neurochemistry. 104: 683-95. PMID 18005001 DOI: 10.1111/J.1471-4159.2007.05072.X  0.837
2008 Zhu X, Siedlak SL, Wang Y, Perry G, Castellani RJ, Cohen ML, Smith MA. Neuronal binucleation in Alzheimer disease hippocampus. Neuropathology and Applied Neurobiology. 34: 457-65. PMID 17995921 DOI: 10.1111/J.1365-2990.2007.00908.X  0.823
2008 Mondragón-Rodríguez S, Mena R, Binder LI, Smith MA, Perry G, García-Sierra F. Conformational changes and cleavage of tau in Pick bodies parallel the early processing of tau found in Alzheimer pathology. Neuropathology and Applied Neurobiology. 34: 62-75. PMID 17971079 DOI: 10.1111/J.1365-2990.2007.00853.X  0.688
2008 Evans TA, Siedlak SL, Lu L, Fu X, Wang Z, McGinnis WR, Fakhoury E, Castellani RJ, Hazen SL, Walsh WJ, Lewis AT, Salomon RG, Smith MA, Perry G, Zhu X. The Autistic Phenotype Exhibits a Remarkably Localized Modification of Brain Protein by Products of Free Radical-Induced Lipid Oxidation American Journal of Biochemistry and Biotechnology. 4: 61-72. DOI: 10.3844/Ajbbsp.2008.61.72  0.799
2008 Avila J, Perry G, Smith MA. Upcoming Meetings Related to Alzheimer's Disease* Journal of Alzheimer's Disease. 14: 459-460. DOI: 10.3233/Jad-2008-14416  0.692
2008 Gonzalez-Cuyar LF, Morrison AL, Perry G, DeJong JJ, Smith MA, Castellani RJ. Cerebrotendinous xanthomatosis: A critical update Future Neurology. 3: 491-501. DOI: 10.2217/14796708.3.4.491  0.758
2008 Bryan K, Lee HG, Perry G, Castellani RJ, Smith MA, Casadesus G. Nonestrogen-based hormonal therapies for Alzheimer's disease Future Neurology. 3: 399-407. DOI: 10.2217/14796708.3.4.399  0.811
2008 Bartocci M, Urlesberger B, Bel Fv, Lemmers P, Naulaers G, Hay WW, Mizuno K, Hida H, Masuda T, Nishino H, Togari H, Yang Q, Smith PB, Goldberg RN, Cotten CM, ... ... Smith MA, et al. Contents Vol. 94, 2008 Neonatology. 94. DOI: 10.1159/000171888  0.514
2008 Bartocci M, Urlesberger B, Bel Fv, Lemmers P, Naulaers G, Hay WW, Mizuno K, Hida H, Masuda T, Nishino H, Togari H, Yang Q, Smith PB, Goldberg RN, Cotten CM, ... ... Smith MA, et al. Subject Index Vol. 94, 2008 Neonatology. 94: 327-328. DOI: 10.1159/000171887  0.513
2008 Zhu X, Wang Y, Ogawa O, Lee HG, Raina AK, Fujioka H, Shimohama S, Atwood CS, Petersen RB, Perry G, Smith MA. Oral Presentations OP01: Neurodegenerative Diseases Journal of Neurochemistry. 81: 76-76. DOI: 10.1046/J.1471-4159.81.S1.44_1.X  0.842
2008 Smith MA, Garrett MR, Lee H, Siedlak SL, Zhu X, Perry G, Friedland RP, Gustaw K. P1-351: A novel approach to diagnosis: Antigen-antibody disassociation in Alzheimer's disease Alzheimer's & Dementia. 4: T321-T321. DOI: 10.1016/J.Jalz.2008.05.933  0.811
2008 Moreira PI, Santos MS, Siedlak SL, Harris P, Smith MA, Aliev G, Perry G, Oliveira CR. P4-185: Mitochondrial dysfunction in Alzheimer's disease Alzheimer's & Dementia. 4: T725-T725. DOI: 10.1016/J.Jalz.2008.05.2252  0.831
2008 Perry G, Cash AD, Harris PL, Siedlak SL, Smith MA, Zhu X. P4-170: Peroxidative nitrotyrosine formation in Alzheimer's disease Alzheimer's & Dementia. 4: T720-T720. DOI: 10.1016/J.Jalz.2008.05.2237  0.839
2008 Zhu X, Wang X, Su B, Fujioka H, Wang Y, Perry G, Smith MA. P4-166: Overexpression of amyloid precursor protein causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins Alzheimer's & Dementia. 4: T719-T719. DOI: 10.1016/J.Jalz.2008.05.2233  0.792
2008 Wang X, Su B, Smith MA, Perry G, Zhu X. P3-422: Impaired balance of mitochondrial fission and fusion in susceptible neurons of Alzheimer disease Alzheimer's & Dementia. 4: T645-T645. DOI: 10.1016/J.Jalz.2008.05.1993  0.834
2008 Lee H, Zhu X, Richardson SL, Perry G, Smith MA. P3-317: Failure in the control of cell cycle causes neurodegeneration Alzheimer's & Dementia. 4: T614-T615. DOI: 10.1016/j.jalz.2008.05.1886  0.773
2007 Webber KM, Casadesus G, Bowen RL, Perry G, Smith MA. Evidence for the role of luteinizing hormone in Alzheimer disease. Endocrine, Metabolic & Immune Disorders Drug Targets. 7: 300-3. PMID 18220951 DOI: 10.2174/187153007782794326  0.844
2007 Nunomura A, Moreira PI, Lee HG, Zhu X, Castellani RJ, Smith MA, Perry G. Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases. Cns & Neurological Disorders Drug Targets. 6: 411-23. PMID 18220780 DOI: 10.2174/187152707783399201  0.863
2007 Nunomura A, Moreira PI, Takeda A, Smith MA, Perry G. Oxidative RNA damage and neurodegeneration. Current Medicinal Chemistry. 14: 2968-75. PMID 18220733 DOI: 10.2174/092986707782794078  0.815
2007 Castellani RJ, Perry G, Smith MA. The role of novel chitin-like polysaccharides in Alzheimer disease. Neurotoxicity Research. 12: 269-74. PMID 18201954 DOI: 10.1007/BF03033910  0.825
2007 Webber KM, Perry G, Smith MA, Casadesus G. The contribution of luteinizing hormone to Alzheimer disease pathogenesis. Clinical Medicine & Research. 5: 177-83. PMID 18056027 DOI: 10.3121/cmr.2007.741  0.84
2007 Wang X, Su B, Perry G, Smith MA, Zhu X. Insights into amyloid-beta-induced mitochondrial dysfunction in Alzheimer disease. Free Radical Biology & Medicine. 43: 1569-73. PMID 18037122 DOI: 10.1016/J.Freeradbiomed.2007.09.007  0.827
2007 Hayashi T, Shishido N, Nakayama K, Nunomura A, Smith MA, Perry G, Nakamura M. Lipid peroxidation and 4-hydroxy-2-nonenal formation by copper ion bound to amyloid-beta peptide. Free Radical Biology & Medicine. 43: 1552-9. PMID 17964426 DOI: 10.1016/j.freeradbiomed.2007.08.013  0.785
2007 Bishop GM, Smith MA, LaManna JC, Wilson AC, Perry G, Atwood CS. Iron homeostasis is maintained in the brain, but not the liver, following mild hypoxia. Redox Report : Communications in Free Radical Research. 12: 257-66. PMID 17961297 DOI: 10.1179/135100007X239270  0.787
2007 Nakamura M, Shishido N, Nunomura A, Smith MA, Perry G, Hayashi Y, Nakayama K, Hayashi T. Three histidine residues of amyloid-beta peptide control the redox activity of copper and iron. Biochemistry. 46: 12737-43. PMID 17929832 DOI: 10.1021/bi701079z  0.811
2007 Moreira PI, Harris PL, Zhu X, Santos MS, Oliveira CR, Smith MA, Perry G. Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts. Journal of Alzheimer's Disease : Jad. 12: 195-206. PMID 17917164 DOI: 10.3233/Jad-2007-12210  0.828
2007 Liu Q, Ju WK, Crowston JG, Xie F, Perry G, Smith MA, Lindsey JD, Weinreb RN. Oxidative stress is an early event in hydrostatic pressure induced retinal ganglion cell damage. Investigative Ophthalmology & Visual Science. 48: 4580-9. PMID 17898281 DOI: 10.1167/iovs.07-0170  0.686
2007 Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G. Increased autophagic degradation of mitochondria in Alzheimer disease. Autophagy. 3: 614-5. PMID 17786024 DOI: 10.4161/Auto.4872  0.865
2007 Pelegrí C, Canudas AM, del Valle J, Casadesus G, Smith MA, Camins A, Pallàs M, Vilaplana J. Increased permeability of blood-brain barrier on the hippocampus of a murine model of senescence. Mechanisms of Ageing and Development. 128: 522-8. PMID 17697702 DOI: 10.1016/j.mad.2007.07.002  0.682
2007 Alvira D, Yeste-Velasco M, Folch J, Casadesús G, Smith MA, Pallàs M, Camins A. Neuroprotective effects of caffeine against complex I inhibition-induced apoptosis are mediated by inhibition of the Atm/p53/E2F-1 path in cerebellar granule neurons. Journal of Neuroscience Research. 85: 3079-88. PMID 17638302 DOI: 10.1002/jnr.21427  0.308
2007 Gonzalez-Cuyar LF, Hunter B, Harris PL, Perry G, Smith MA, Castellani RJ. Cerebrotendinous xanthomatosis: case report with evidence of oxidative stress. Redox Report : Communications in Free Radical Research. 12: 119-24. PMID 17623518 DOI: 10.1179/135100007X200173  0.823
2007 Zhu X, Su B, Wang X, Smith MA, Perry G. Causes of oxidative stress in Alzheimer disease. Cellular and Molecular Life Sciences : Cmls. 64: 2202-10. PMID 17605000 DOI: 10.1007/S00018-007-7218-4  0.862
2007 Li J, Xia X, Ke Y, Nie H, Smith MA, Zhu X. Trichosanthin induced apoptosis in HL-60 cells via mitochondrial and endoplasmic reticulum stress signaling pathways. Biochimica Et Biophysica Acta. 1770: 1169-80. PMID 17570595 DOI: 10.1016/j.bbagen.2007.04.007  0.715
2007 Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G. Autophagocytosis of mitochondria is prominent in Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 66: 525-32. PMID 17549012 DOI: 10.1016/J.Jns.2009.02.162  0.847
2007 Petersen RB, Nunomura A, Lee HG, Casadesus G, Perry G, Smith MA, Zhu X. Signal transduction cascades associated with oxidative stress in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 11: 143-52. PMID 17522439 DOI: 10.3233/Jad-2007-11202  0.863
2007 Castellani RJ, Moreira PI, Liu G, Dobson J, Perry G, Smith MA, Zhu X. Iron: the Redox-active center of oxidative stress in Alzheimer disease. Neurochemical Research. 32: 1640-5. PMID 17508283 DOI: 10.1007/S11064-007-9360-7  0.846
2007 Evans TA, Raina AK, Delacourte A, Aprelikova O, Lee HG, Zhu X, Perry G, Smith MA. BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease. International Journal of Medical Sciences. 4: 140-5. PMID 17505559 DOI: 10.7150/Ijms.4.140  0.853
2007 Castellani RJ, Zhu X, Lee HG, Moreira PI, Perry G, Smith MA. Neuropathology and treatment of Alzheimer disease: did we lose the forest for the trees? Expert Review of Neurotherapeutics. 7: 473-85. PMID 17492899 DOI: 10.1586/14737175.7.5.473  0.833
2007 Zhu X, Avila J, Perry G, Smith MA. Treating the lesions, not the disease. The American Journal of Pathology. 170: 1457-9. PMID 17456753 DOI: 10.2353/ajpath.2007.070193  0.841
2007 Thakur A, Wang X, Siedlak SL, Perry G, Smith MA, Zhu X. c-Jun phosphorylation in Alzheimer disease. Journal of Neuroscience Research. 85: 1668-73. PMID 17455299 DOI: 10.1002/Jnr.21298  0.826
2007 Casadesus G, Milliken EL, Webber KM, Bowen RL, Lei Z, Rao CV, Perry G, Keri RA, Smith MA. Increases in luteinizing hormone are associated with declines in cognitive performance. Molecular and Cellular Endocrinology. 269: 107-11. PMID 17376589 DOI: 10.1016/J.Mce.2006.06.013  0.791
2007 Casadesus G, Moreira PI, Nunomura A, Siedlak SL, Bligh-Glover W, Balraj E, Petot G, Smith MA, Perry G. Indices of metabolic dysfunction and oxidative stress. Neurochemical Research. 32: 717-22. PMID 17342408 DOI: 10.1007/S11064-007-9296-Y  0.853
2007 Zhu X, Smith MA, Honda K, Aliev G, Moreira PI, Nunomura A, Casadesus G, Harris PL, Siedlak SL, Perry G. Vascular oxidative stress in Alzheimer disease. Journal of the Neurological Sciences. 257: 240-6. PMID 17337008 DOI: 10.1016/J.Jns.2007.01.039  0.852
2007 Wung JK, Perry G, Kowalski A, Harris PL, Bishop GM, Trivedi MA, Johnson SC, Smith MA, Denhardt DT, Atwood CS. Increased expression of the remodeling- and tumorigenic-associated factor osteopontin in pyramidal neurons of the Alzheimer's disease brain. Current Alzheimer Research. 4: 67-72. PMID 17316167 DOI: 10.2174/156720507779939869  0.844
2007 Liu Q, Xie F, Rolston R, Moreira PI, Nunomura A, Zhu X, Smith MA, Perry G. Prevention and treatment of Alzheimer disease and aging: antioxidants. Mini Reviews in Medicinal Chemistry. 7: 171-80. PMID 17305591 DOI: 10.2174/138955707779802552  0.862
2007 Casadesus G, Smith MA, Basu S, Hua J, Capobianco DE, Siedlak SL, Zhu X, Perry G. Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease. Molecular Neurodegeneration. 2: 2. PMID 17241462 DOI: 10.1186/1750-1326-2-2  0.862
2007 Lee HG, Zhu X, Castellani RJ, Nunomura A, Perry G, Smith MA. Amyloid-beta in Alzheimer disease: the null versus the alternate hypotheses. The Journal of Pharmacology and Experimental Therapeutics. 321: 823-9. PMID 17229880 DOI: 10.1124/jpet.106.114009  0.845
2007 Woods J, Snape M, Smith MA. The cell cycle hypothesis of Alzheimer's disease: suggestions for drug development. Biochimica Et Biophysica Acta. 1772: 503-8. PMID 17223322 DOI: 10.1016/j.bbadis.2006.12.004  0.346
2007 Zhu X, Lee HG, Perry G, Smith MA. Alzheimer disease, the two-hit hypothesis: an update. Biochimica Et Biophysica Acta. 1772: 494-502. PMID 17142016 DOI: 10.1016/j.bbadis.2006.10.014  0.854
2007 McShea A, Lee HG, Petersen RB, Casadesus G, Vincent I, Linford NJ, Funk JO, Shapiro RA, Smith MA. Neuronal cell cycle re-entry mediates Alzheimer disease-type changes. Biochimica Et Biophysica Acta. 1772: 467-72. PMID 17095196 DOI: 10.1016/J.Bbadis.2006.09.010  0.826
2007 Webber KM, Casadesus G, Atwood CS, Bowen RL, Perry G, Smith MA. Gonadotropins: a cohesive gender-based etiology of Alzheimer disease. Molecular and Cellular Endocrinology. 260: 271-5. PMID 17052835 DOI: 10.1016/J.Mce.2006.01.018  0.831
2007 Previll LA, Crosby ME, Castellani RJ, Bowser R, Perry G, Smith MA, Zhu X. Increased expression of p130 in Alzheimer disease. Neurochemical Research. 32: 639-44. PMID 17006760 DOI: 10.1007/S11064-006-9146-3  0.843
2007 Bonda DJ, Webber KM, Siedlak SL, Perry G, Friedland RP, Smith MA. The Pathology of Alzheimer Disease Elicits an In Vivo Immunological Response American Journal of Immunology. 3: 10-14. DOI: 10.3844/Ajisp.2007.10.14  0.833
2007 Perry G, Smith MA. Sir Martin Roth – A Debt of Gratitude Journal of Alzheimer's Disease. 11: 1-1. DOI: 10.3233/JAD-2007-11101  0.519
2007 Perry G, Moreira PI, Siedlak SL, Santos MS, Oliveira CR, Fujioka H, Tabaton M, Nunomura A, Aliev G, Szweda LI, Smith MA. Mitochondrial autophagocytosis in Alzheimer disease Journal of Neuropathology and Experimental Neurology. 66: 434. DOI: 10.1097/01.Jnen.0000268871.37441.1B  0.833
2007 Perry G, Moreira PI, Harris PL, Zhu X, Santos MS, Oliveira CR, Smith MA. Lipoic acid and N-acetyl cysteine protect against mitochondrial-related oxidative stress in fibroblasts from Alzheimer disease patients Journal of Neuropathology and Experimental Neurology. 66: 434. DOI: 10.1097/01.Jnen.0000268870.37441.52  0.83
2007 Aliev G, Perry G, Shenk J, Puchowicz M, Xu K, Siedlak S, Obrenovich M, Smith M, Friedland R, Chen S, Ames B, Liu J, DeLaTore J, LaManna J, Koistinaho J. PO13-357 THE PRIMARY PATHOGENETIC ROLE OF VASCULAR HYPOPERFUSION, AND OXIDATIVE STRESS IN ALZHEIMER DISEASE Atherosclerosis Supplements. 8: 105. DOI: 10.1016/S1567-5688(07)71367-3  0.838
2007 Smith MA, Arendt T, Vincent I, Zhu X. Cell cycle dysregulation and neurodegenerative diseases Biochimica Et Biophysica Acta - Molecular Basis of Disease. 1772: 391. DOI: 10.1016/J.Bbadis.2007.01.012  0.772
2007 Nunomura A, Perry G, Smith MA. Prospects for antioxidant therapy in mild cognitive impairment and alzheimer's disease Oxidative Stress and Neurodegenerative Disorders. 451-466. DOI: 10.1016/B978-044452809-4/50161-7  0.817
2007 Moreira PI, Smith MA, Zhu X, Nunomura A, Perry G. The potential application of antioxidant agents in Alzheimer disease therapeutics Pharmacological Mechanisms in Alzheimer's Therapeutics. 194-211. DOI: 10.1007/978-0-387-71522-3_12  0.831
2007 Liu G, Men P, Perry G, Smith MA. Nanoparticles for the Treatment of Alzheimer's Disease: Theoretical Rationale, Present Status and Future Perspectives Nanotechnologies For the Life Sciences. DOI: 10.1002/9783527610419.Ntls0122  0.615
2006 Smith MA, Zhu X, Lee HG, Harris PL, Fortino AE, Perry G, Castellani RJ. Sequestration of p27 within the cytoplasm of cardiac myocytes in chronic ischemic heart disease: pathogenic implications for ischemic cardiomyopathy. Age (Dordrecht, Netherlands). 28: 85-91. PMID 23598681 DOI: 10.1007/S11357-006-9001-0  0.801
2006 Franco S, Blasco MA, Siedlak SL, Harris PL, Moreira PI, Perry G, Smith MA. Telomeres and telomerase in Alzheimer's disease: epiphenomena or a new focus for therapeutic strategy? Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 2: 164-8. PMID 19595878 DOI: 10.1016/J.Jalz.2006.03.001  0.84
2006 Zhu X, Babar A, Siedlak SL, Yang Q, Ito G, Iwatsubo T, Smith MA, Perry G, Chen SG. LRRK2 in Parkinson's disease and dementia with Lewy bodies. Molecular Neurodegeneration. 1: 17. PMID 17137507 DOI: 10.1186/1750-1326-1-17  0.793
2006 McShea A, Marlatt MW, Lee HG, Tarkowsky SM, Smit M, Smith MA. The application of microarray technology to neuropathology: cutting edge tool with clinical diagnostics potential or too much information? Journal of Neuropathology and Experimental Neurology. 65: 1031-9. PMID 17086099 DOI: 10.1097/01.jnen.0000240471.04920.3c  0.796
2006 Lee HG, Ueda M, Miyamoto Y, Yoneda Y, Perry G, Smith MA, Zhu X. Aberrant localization of importin alpha1 in hippocampal neurons in Alzheimer disease. Brain Research. 1124: 1-4. PMID 17070506 DOI: 10.1016/J.Brainres.2006.09.084  0.836
2006 Nunomura A, Honda K, Takeda A, Hirai K, Zhu X, Smith MA, Perry G. Oxidative damage to RNA in neurodegenerative diseases. Journal of Biomedicine & Biotechnology. 2006: 82323. PMID 17047315 DOI: 10.1155/Jbb/2006/82323  0.834
2006 Casadesus G, Puig ER, Webber KM, Atwood CS, Escuer MC, Bowen RL, Perry G, Smith MA. Targeting gonadotropins: an alternative option for Alzheimer disease treatment. Journal of Biomedicine & Biotechnology. 2006: 39508. PMID 17047306 DOI: 10.1155/Jbb/2006/39508  0.834
2006 Dwyer BE, Stone ML, Zhu X, Perry G, Smith MA. Heme deficiency in Alzheimer's disease: a possible connection to porphyria. Journal of Biomedicine & Biotechnology. 2006: 24038. PMID 17047301 DOI: 10.1155/JBB/2006/24038  0.835
2006 Webber KM, Stocco DM, Casadesus G, Bowen RL, Atwood CS, Previll LA, Harris PL, Zhu X, Perry G, Smith MA. Steroidogenic acute regulatory protein (StAR): evidence of gonadotropin-induced steroidogenesis in Alzheimer disease. Molecular Neurodegeneration. 1: 14. PMID 17018137 DOI: 10.1186/1750-1326-1-14  0.849
2006 Zhu X, Raina AK, Perry G, Smith MA. Apoptosis in Alzheimer disease: a mathematical improbability. Current Alzheimer Research. 3: 393-6. PMID 17017869 DOI: 10.2174/156720506778249470  0.834
2006 Obrenovich ME, Smith MA, Siedlak SL, Chen SG, de la Torre JC, Perry G, Aliev G. Overexpression of GRK2 in Alzheimer disease and in a chronic hypoperfusion rat model is an early marker of brain mitochondrial lesions. Neurotoxicity Research. 10: 43-56. PMID 17000469 DOI: 10.1007/Bf03033333  0.828
2006 Lee HG, Ueda M, Zhu X, Perry G, Smith MA. Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway? Journal of Neuroscience Research. 84: 1856-61. PMID 16998902 DOI: 10.1002/jnr.21072  0.825
2006 Strobel G, Smith M, Gandy S, Breitner J, Wise P, Toran-Allerand D, Atwood C, Gregory C, Li R, McAsey M, Brinton R, Barbee J, Struble R, Zandi P, Zhao L, et al. Alzheimer research forum live discussion: Not dead yet: Estrogen deserves another chance Journal of Alzheimer's Disease. 10: 121-130. PMID 16988489 DOI: 10.3233/jad-2006-10116  0.668
2006 Lam-Himlin D, Espey MG, Perry G, Smith MA, Castellani RJ. Malignant glioma progression and nitric oxide. Neurochemistry International. 49: 764-8. PMID 16971023 DOI: 10.1016/j.neuint.2006.07.001  0.772
2006 Li J, Xia X, Nie H, Smith MA, Zhu X. PKC inhibition is involved in trichosanthin-induced apoptosis in human chronic myeloid leukemia cell line K562. Biochimica Et Biophysica Acta. 1770: 63-70. PMID 16949756 DOI: 10.1016/J.BBAGEN.2006.07.011  0.71
2006 Lee HG, Zhu X, Nunomura A, Perry G, Smith MA. Amyloid-beta vaccination: testing the amyloid hypothesis?: heads we win, tails you lose! The American Journal of Pathology. 169: 738-9. PMID 16936250 DOI: 10.2353/ajpath.2006.060633  0.827
2006 Liu G, Men P, Harris PL, Rolston RK, Perry G, Smith MA. Nanoparticle iron chelators: a new therapeutic approach in Alzheimer disease and other neurologic disorders associated with trace metal imbalance. Neuroscience Letters. 406: 189-93. PMID 16919875 DOI: 10.1016/J.Neulet.2006.07.020  0.824
2006 Smith MA. Oxidative stress and iron imbalance in Alzheimer disease: how rust became the fuss! Journal of Alzheimer's Disease : Jad. 9: 305-8. PMID 16914868 DOI: 10.3233/JAD-2006-9S334  0.484
2006 Zhu X, Perry G, Moreira PI, Aliev G, Cash AD, Hirai K, Smith MA. Mitochondrial abnormalities and oxidative imbalance in Alzheimer disease. Journal of Alzheimer's Disease : Jad. 9: 147-53. PMID 16873962 DOI: 10.3233/JAD-2006-9207  0.826
2006 Zhu X, Siedlak SL, Smith MA, Perry G, Chen SG. LRRK2 protein is a component of Lewy bodies. Annals of Neurology. 60: 617-8; author reply . PMID 16847950 DOI: 10.1002/Ana.20928  0.764
2006 Nunomura A, Castellani RJ, Zhu X, Moreira PI, Perry G, Smith MA. Involvement of oxidative stress in Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 65: 631-41. PMID 16825950 DOI: 10.1097/01.jnen.0000228136.58062.bf  0.856
2006 Lee HG, Perry G, Zhu X, Nunomura A, Smith MA. Amyloid-beta, BACE, and oxidative stress in Alzheimer's disease, a commentary on "The different aggregation state of beta-amyloid 1-42 mediates different effects on oxidative stress, neurodegeneration and BACE-1 expression". Free Radical Biology & Medicine. 41: 188-9. PMID 16814097 DOI: 10.1016/j.freeradbiomed.2006.03.014  0.834
2006 Moreira PI, Zhu X, Nunomura A, Smith MA, Perry G. Therapeutic options in Alzheimer's disease. Expert Review of Neurotherapeutics. 6: 897-910. PMID 16784412 DOI: 10.1586/14737175.6.6.897  0.842
2006 Lee HG, Zhu X, Takeda A, Perry G, Smith MA. Emerging evidence for the neuroprotective role of alpha-synuclein. Experimental Neurology. 200: 1-7. PMID 16780837 DOI: 10.1016/J.Expneurol.2006.04.024  0.768
2006 Casadesus G, Garrett MR, Webber KM, Hartzler AW, Atwood CS, Perry G, Bowen RL, Smith MA. The estrogen myth: potential use of gonadotropin-releasing hormone agonists for the treatment of Alzheimer's disease. Drugs in R&D. 7: 187-93. PMID 16752944 DOI: 10.2165/00126839-200607030-00004  0.826
2006 Castellani RJ, Lee HG, Zhu X, Nunomura A, Perry G, Smith MA. Neuropathology of Alzheimer disease: pathognomonic but not pathogenic. Acta Neuropathologica. 111: 503-9. PMID 16718346 DOI: 10.1007/s00401-006-0071-y  0.869
2006 Nunomura A, Castellani RJ, Lee HG, Moreira PI, Zhu X, Perry G, Smith MA. Neuropathology in Alzheimer's disease: awaking from a hundred-year-old dream. Science of Aging Knowledge Environment : Sage Ke. 2006: pe10. PMID 16672726 DOI: 10.1126/sageke.2006.8.pe10  0.875
2006 Castellani RJ, Lee HG, Perry G, Smith MA. Antioxidant protection and neurodegenerative disease: the role of amyloid-beta and tau. American Journal of Alzheimer's Disease and Other Dementias. 21: 126-30. PMID 16634469 DOI: 10.1177/153331750602100213  0.862
2006 Moreira PI, Zhu X, Liu Q, Honda K, Siedlak SL, Harris PL, Smith MA, Perry G. Compensatory responses induced by oxidative stress in Alzheimer disease. Biological Research. 39: 7-13. PMID 16629160 DOI: 10.4067/S0716-97602006000100002  0.876
2006 Hasegawa T, Matsuzaki-Kobayashi M, Takeda A, Sugeno N, Kikuchi A, Furukawa K, Perry G, Smith MA, Itoyama Y. Alpha-synuclein facilitates the toxicity of oxidized catechol metabolites: implications for selective neurodegeneration in Parkinson's disease. Febs Letters. 580: 2147-52. PMID 16567160 DOI: 10.1016/J.Febslet.2006.03.018  0.671
2006 Lee HG, Zhu X, Perry G, Smith MA. The fallacy of amyloid and cognition in Alzheimer's disease. Drugs & Aging. 23: 179. PMID 16536639 DOI: 10.2165/00002512-200623020-00007  0.833
2006 Zhu X, Lee HG, Moreira PI, Smith MA, Perry G. Presenilin mutation: a deadly first hit in Alzheimer disease. A commentary on "aging sensitizes towards ROS formation and lipid peroxidation in PS1M146L transgenic mice". Free Radical Biology & Medicine. 40: 737-9. PMID 16520226 DOI: 10.1016/j.freeradbiomed.2005.12.028  0.813
2006 Moreira PI, Zhu X, Lee HG, Honda K, Smith MA, Perry G. The (un)balance between metabolic and oxidative abnormalities and cellular compensatory responses in Alzheimer disease. Mechanisms of Ageing and Development. 127: 501-6. PMID 16516950 DOI: 10.1016/j.mad.2006.01.024  0.848
2006 Casadesus G, Webber KM, Atwood CS, Pappolla MA, Perry G, Bowen RL, Smith MA. Luteinizing hormone modulates cognition and amyloid-beta deposition in Alzheimer APP transgenic mice. Biochimica Et Biophysica Acta. 1762: 447-52. PMID 16503402 DOI: 10.1016/J.Bbadis.2006.01.008  0.834
2006 Lee HG, Zhu X, Nunomura A, Perry G, Smith MA. Amyloid beta: the alternate hypothesis. Current Alzheimer Research. 3: 75-80. PMID 16472207 DOI: 10.2174/156720506775697124  0.843
2006 Webber KM, Casadesus G, Zhu X, Obrenovich ME, Atwood CS, Perry G, Bowen RL, Smith MA. The cell cycle and hormonal fluxes in Alzheimer disease: a novel therapeutic target. Current Pharmaceutical Design. 12: 691-7. PMID 16472159 DOI: 10.2174/138161206775474305  0.877
2006 Gregory CW, Atwood CS, Smith MA, Bowen RL. Antigonadotropins: a novel strategy to halt Alzheimer's disease progression. Current Pharmaceutical Design. 12: 685-90. PMID 16472158 DOI: 10.2174/138161206775474288  0.782
2006 Strocchi P, Smith MA, Perry G, Tamagno E, Danni O, Pession A, Gaiba A, Dozza B. Clusterin up-regulation following sub-lethal oxidative stress and lipid peroxidation in human neuroblastoma cells. Neurobiology of Aging. 27: 1588-94. PMID 16464517 DOI: 10.1016/j.neurobiolaging.2005.09.019  0.624
2006 Moreira PI, Honda K, Zhu X, Nunomura A, Casadesus G, Smith MA, Perry G. Brain and brawn: parallels in oxidative strength. Neurology. 66: S97-101. PMID 16432155 DOI: 10.1212/01.wnl.0000192307.15103.83  0.869
2006 Perry G, Avila J, Kinoshita J, Smith MA. Alzheimer's disease: A century of scientific and clinical research Journal of Alzheimer's Disease. 9: 1-1. DOI: 10.3233/JAD-2006-9S301  0.64
2006 Smith M, Jagannathan Rao K, Perry G. Foreword: Apoptotic Mechanisms in Neurodegenerative Diseases Current Alzheimer Research. 3: 267-267. DOI: 10.2174/156720506778249443  0.661
2006 Sha O, Kwong WH, Dong M, Wang X, Chan AK, Burns AJ, Chan WY, Castellani RJ, Zhu X, Lee H, Perry G, Smith MA, Casadesus G, Kanaumi T, Ichinohe A, et al. Contents Vol. 4, 2006–2007 Neuroembryology and Aging. 4. DOI: 10.1159/000121404  0.753
2006 Castellani RJ, Zhu X, Lee HG, Perry G, Smith MA, Casadesus G. Neurogenesis in human hippocampus: Implications for Alzheimer disease pathogenesis Neuroembryology and Aging. 4: 175-182. DOI: 10.1159/000118927  0.829
2006 Wilson AC, Salamat MS, Meethal SV, Smith MA, Terasawa E, Bowen RL, Atwood CS. Extrapituitary expression of luteinizing hormone by human neurons possessing GnRH receptor 1 Frontiers in Neuroendocrinology. 27: 87-88. DOI: 10.1016/J.Yfrne.2006.03.190  0.719
2006 Lee H, Ueda M, Zhu X, Perry G, Smith MA. P1-417: Ectopic localization of phospho-Smad2 in the vulnerable neurons of Alzheimer's disease Alzheimer's & Dementia. 2: S220-S220. DOI: 10.1016/j.jalz.2006.05.796  0.838
2006 Lee H, Ueda M, Zhu X, Perry G, Smith MA. P1-388: Failure of cytoplasmic-nuclear transport in Alzheimer's disease Alzheimer's & Dementia. 2: S211-S212. DOI: 10.1016/j.jalz.2006.05.766  0.817
2006 Webber KM, Casadesus G, Previll LA, Zhu X, Gregory C, Bowen R, Atwood CS, Perry G, Stocco DM, Smith MA. P1-369: Evidence of gonadotropin-induced steroidogenesis in Alzheimer's disease Alzheimer's & Dementia. 2: S206-S206. DOI: 10.1016/J.Jalz.2006.05.747  0.841
2006 Smith MA, Lee H, Vincent I, Linford NJ, Funk J, Shapiro RA, McShea A. S5-02-04: Cell cycle re-entry mediates Alzheimer-type changes in neurons in vitro Alzheimer's & Dementia. 2: S91-S92. DOI: 10.1016/J.Jalz.2006.05.358  0.719
2006 Moreira PI, Siedlak SL, Santos MS, Oliveira CR, Fujioka H, Tabaton M, Nunomura A, Aliev G, Szweda LI, Zhu X, Smith MA, Perry G. O4-02-08: Mitochondrial autophagocytosis in Alzheimer disease Alzheimer's & Dementia. 2: S79-S79. DOI: 10.1016/J.Jalz.2006.05.307  0.821
2006 Reynolds BD, Smith MA, Gregory CW. P4-354: Luteinizing hormone: A unifying hypothesis for Alzheimer disease etiology, pathogenesis and treatment Alzheimer's & Dementia. 2: S621-S621. DOI: 10.1016/j.jalz.2006.05.2095  0.437
2006 Smith MA, Zhu X, Babar A, Siedlak SL, Yang Q, Ito G, Iwatsubo T, Perry G, Chen SG. P4-162: LRRK2 in Lewy bodies of Parkinson's disease and dementia with Lewy bodies Alzheimer's & Dementia. 2: S564-S564. DOI: 10.1016/J.Jalz.2006.05.1901  0.805
2006 Moreira PI, Harris PL, Zhu X, Santos MS, Oliveira CR, Smith MA, Perry G. P3-375: Lipoic acid and N -acetyl cysteine protect against mitochondrial-related oxidative stress in fibroblasts from Alzheimer disease patients Alzheimer's & Dementia. 2: S486-S486. DOI: 10.1016/J.Jalz.2006.05.1645  0.83
2006 Nunomura A, Chiba S, Yamaguchi H, Smith MA, Perry G. P3-369: Intraneuronal amyloid-β42 may silence oxidative stress in Alzheimer's disease Alzheimer's & Dementia. 2: S484-S484. DOI: 10.1016/j.jalz.2006.05.1639  0.842
2006 Casadesus G, Webber KM, Atwood CS, Bowen RL, Perry G, Smith MA. P3-296: Luteinizing hormone mediates Alzheimer-type changes in neurons Alzheimer's & Dementia. 2: S462-S462. DOI: 10.1016/J.Jalz.2006.05.1565  0.809
2006 Smith MA, Previll LA, Crosby ME, Zhu X, Bowser R, Perry G. P3-229: P130, a regulator of the G1 phase of the cell cycle, in Alzheimer disease: Evidence of a stuttered cell cycle Alzheimer's & Dementia. 2: S443-S443. DOI: 10.1016/J.Jalz.2006.05.1498  0.802
2005 Casadesus G, Smith MA, Perry G. Commentary: "Ceramide and cholesterol: possible connections between normal aging of the brain and Alzheimer's disease. Just hypotheses or molecular pathways to be identified?" by Claudio Costantini, Rekha M.K. Kolasani, and Luigi Puglielli. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 1: 51-2. PMID 19595817 DOI: 10.1016/j.jalz.2005.06.011  0.79
2005 Castellani RJ, Siedlak SL, Fortino AE, Perry G, Ghetti B, Smith MA. Chitin-like polysaccharides in Alzheimer's disease brains. Current Alzheimer Research. 2: 419-23. PMID 16248847 DOI: 10.2174/156720505774330555  0.835
2005 Moreira PI, Honda K, Liu Q, Santos MS, Oliveira CR, Aliev G, Nunomura A, Zhu X, Smith MA, Perry G. Oxidative stress: the old enemy in Alzheimer's disease pathophysiology. Current Alzheimer Research. 2: 403-8. PMID 16248845 DOI: 10.2174/156720505774330537  0.854
2005 Sayre LM, Moreira PI, Smith MA, Perry G. Metal ions and oxidative protein modification in neurological disease. Annali Dell'Istituto Superiore Di Sanitã . 41: 143-64. PMID 16244388  0.834
2005 Zhu X, Mei M, Lee HG, Wang Y, Han J, Perry G, Smith MA. P38 activation mediates amyloid-beta cytotoxicity. Neurochemical Research. 30: 791-6. PMID 16187214 DOI: 10.1007/s11064-005-6872-x  0.829
2005 Dwyer BE, Takeda A, Zhu X, Perry G, Smith MA. Ferric cycle activity and Alzheimer disease. Current Neurovascular Research. 2: 261-7. PMID 16181119 DOI: 10.2174/1567202054368371  0.859
2005 Moreira PI, Oliveira CR, Santos MS, Nunomura A, Honda K, Zhu X, Smith MA, Perry G. A second look into the oxidant mechanisms in Alzheimer's disease. Current Neurovascular Research. 2: 179-84. PMID 16181112 DOI: 10.2174/1567202053586758  0.863
2005 Santa-María I, Hernández F, Smith MA, Perry G, Avila J, Moreno FJ. Neurotoxic dopamine quinone facilitates the assembly of tau into fibrillar polymers. Molecular and Cellular Biochemistry. 278: 203-12. PMID 16180106 DOI: 10.1007/S11010-005-7499-6  0.646
2005 Yu X, Caltagarone J, Smith MA, Bowser R. DNA damage induces cdk2 protein levels and histone H2B phosphorylation in SH-SY5Y neuroblastoma cells. Journal of Alzheimer's Disease : Jad. 8: 7-21. PMID 16155345 DOI: 10.3233/Jad-2005-8102  0.355
2005 Lin D, Lee HG, Liu Q, Perry G, Smith MA, Sayre LM. 4-Oxo-2-nonenal is both more neurotoxic and more protein reactive than 4-hydroxy-2-nonenal. Chemical Research in Toxicology. 18: 1219-31. PMID 16097795 DOI: 10.1021/Tx050080Q  0.789
2005 Petersen RB, Siedlak SL, Lee HG, Kim YS, Nunomura A, Tagliavini F, Ghetti B, Cras P, Moreira PI, Castellani RJ, Guentchev M, Budka H, Ironside JW, Gambetti P, Smith MA, et al. Redox metals and oxidative abnormalities in human prion diseases. Acta Neuropathologica. 110: 232-8. PMID 16096758 DOI: 10.1007/S00401-005-1034-4  0.854
2005 Zhu X, Moreira PI, Smith MA, Perry G. Alzheimer's disease: an intracellular movement disorder? Trends in Molecular Medicine. 11: 391-3. PMID 16087404 DOI: 10.1016/j.molmed.2005.07.002  0.814
2005 Liu G, Garrett MR, Men P, Zhu X, Perry G, Smith MA. Nanoparticle and other metal chelation therapeutics in Alzheimer disease. Biochimica Et Biophysica Acta. 1741: 246-52. PMID 16051470 DOI: 10.1016/j.bbadis.2005.06.006  0.833
2005 Moreira PI, Smith MA, Zhu X, Nunomura A, Castellani RJ, Perry G. Oxidative stress and neurodegeneration. Annals of the New York Academy of Sciences. 1043: 545-52. PMID 16037277 DOI: 10.1196/annals.1333.062  0.856
2005 Meethal SV, Smith MA, Bowen RL, Atwood CS. The gonadotropin connection in Alzheimer's disease. Endocrine. 26: 317-26. PMID 16034187 DOI: 10.1385/Endo:26:3:317  0.791
2005 Webber KM, Casadesus G, Marlatt MW, Perry G, Hamlin CR, Atwood CS, Bowen RL, Smith MA. Estrogen bows to a new master: the role of gonadotropins in Alzheimer pathogenesis. Annals of the New York Academy of Sciences. 1052: 201-9. PMID 16024763 DOI: 10.1196/Annals.1347.020  0.815
2005 Hagemann TL, Gaeta SA, Smith MA, Johnson DA, Johnson JA, Messing A. Gene expression analysis in mice with elevated glial fibrillary acidic protein and Rosenthal fibers reveals a stress response followed by glial activation and neuronal dysfunction. Human Molecular Genetics. 14: 2443-58. PMID 16014634 DOI: 10.1093/Hmg/Ddi248  0.349
2005 Ma YL, Zhu X, Rivera PM, Tøien Ø, Barnes BM, LaManna JC, Smith MA, Drew KL. Absence of cellular stress in brain after hypoxia induced by arousal from hibernation in Arctic ground squirrels. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 289: R1297-306. PMID 15976308 DOI: 10.1152/Ajpregu.00260.2005  0.799
2005 Zhu X, Lee HG, Casadesus G, Avila J, Drew K, Perry G, Smith MA. Oxidative imbalance in Alzheimer's disease. Molecular Neurobiology. 31: 205-17. PMID 15953822 DOI: 10.1385/Mn:31:1-3:205  0.852
2005 Santa-María I, Smith MA, Perry G, Hernández F, Avila J, Moreno FJ. Effect of quinones on microtubule polymerization: a link between oxidative stress and cytoskeletal alterations in Alzheimer's disease. Biochimica Et Biophysica Acta. 1740: 472-80. PMID 15949717 DOI: 10.1016/J.Bbadis.2004.11.024  0.693
2005 Webber KM, Casadesus G, Perry G, Atwood CS, Bowen R, Smith MA. Gender differences in Alzheimer disease: the role of luteinizing hormone in disease pathogenesis. Alzheimer Disease and Associated Disorders. 19: 95-9. PMID 15942328 DOI: 10.1097/01.Wad.0000165512.90864.3F  0.826
2005 Webber KM, Raina AK, Marlatt MW, Zhu X, Prat MI, Morelli L, Casadesus G, Perry G, Smith MA. The cell cycle in Alzheimer disease: a unique target for neuropharmacology. Mechanisms of Ageing and Development. 126: 1019-25. PMID 15936057 DOI: 10.1016/J.Mad.2005.03.024  0.881
2005 Lee HG, Castellani RJ, Zhu X, Perry G, Smith MA. Amyloid-beta in Alzheimer's disease: the horse or the cart? Pathogenic or protective? International Journal of Experimental Pathology. 86: 133-8. PMID 15910547 DOI: 10.1111/j.0959-9673.2005.00429.x  0.842
2005 Sahin M, Karauzum SB, Perry G, Smith MA, Aliciguzel Y. Retinoic acid isomers protect hippocampal neurons from amyloid-beta induced neurodegeneration. Neurotoxicity Research. 7: 243-50. PMID 15897158 DOI: 10.1007/Bf03036453  0.824
2005 Marlatt MW, Webber KM, Moreira PI, Lee HG, Casadesus G, Honda K, Zhu X, Perry G, Smith MA. Therapeutic opportunities in Alzheimer disease: one for all or all for one? Current Medicinal Chemistry. 12: 1137-47. PMID 15892629 DOI: 10.2174/0929867053764644  0.857
2005 Zhu X, Smith MA, Perry G, Wang Y, Ross AP, Zhao HW, Lamanna JC, Drew KL. MAPKs are differentially modulated in arctic ground squirrels during hibernation. Journal of Neuroscience Research. 80: 862-8. PMID 15884016 DOI: 10.1002/Jnr.20526  0.783
2005 Reddy VP, Garrett MR, Perry G, Smith MA. Carnosine: a versatile antioxidant and antiglycating agent. Science of Aging Knowledge Environment : Sage Ke. 2005: pe12. PMID 15872311 DOI: 10.1126/sageke.2005.18.pe12  0.597
2005 Zaidi SI, Richardson SL, Capellari S, Song L, Smith MA, Ghetti B, Sy MS, Gambetti P, Petersen RB. Characterization of the F198S prion protein mutation: enhanced glycosylation and defective refolding. Journal of Alzheimer's Disease : Jad. 7: 159-71; discussion 1. PMID 15851854 DOI: 10.3233/Jad-2005-7209  0.552
2005 Lee HG, Perry G, Moreira PI, Garrett MR, Liu Q, Zhu X, Takeda A, Nunomura A, Smith MA. Tau phosphorylation in Alzheimer's disease: pathogen or protector? Trends in Molecular Medicine. 11: 164-9. PMID 15823754 DOI: 10.1016/J.Molmed.2005.02.008  0.869
2005 Honda K, Smith MA, Zhu X, Baus D, Merrick WC, Tartakoff AM, Hattier T, Harris PL, Siedlak SL, Fujioka H, Liu Q, Moreira PI, Miller FP, Nunomura A, Shimohama S, et al. Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron. The Journal of Biological Chemistry. 280: 20978-86. PMID 15767256 DOI: 10.1074/Jbc.M500526200  0.808
2005 Casadesus G, Shukitt-Hale B, Stellwagen HM, Smith MA, Rabin BM, Joseph JA. Hippocampal neurogenesis and PSA-NCAM expression following exposure to 56Fe particles mimics that seen during aging in rats. Experimental Gerontology. 40: 249-54. PMID 15763403 DOI: 10.1016/J.Exger.2004.09.007  0.725
2005 Aliyev A, Chen SG, Seyidova D, Smith MA, Perry G, de la Torre J, Aliev G. Mitochondria DNA deletions in atherosclerotic hypoperfused brain microvessels as a primary target for the development of Alzheimer's disease. Journal of the Neurological Sciences. 229: 285-92. PMID 15760652 DOI: 10.1016/J.Jns.2004.11.040  0.789
2005 Moreira PI, Smith MA, Zhu X, Honda K, Lee HG, Aliev G, Perry G. Oxidative damage and Alzheimer's disease: are antioxidant therapies useful? Drug News & Perspectives. 18: 13-9. PMID 15753972 DOI: 10.1358/Dnp.2005.18.1.877164  0.859
2005 Atwood CS, Meethal SV, Liu T, Wilson AC, Gallego M, Smith MA, Bowen RL. Dysregulation of the hypothalamic-pituitary-gonadal axis with menopause and andropause promotes neurodegenerative senescence. Journal of Neuropathology and Experimental Neurology. 64: 93-103. PMID 15751223 DOI: 10.1093/Jnen/64.2.93  0.778
2005 Zhu X, Perry G, Smith MA. Insulin signaling, diabetes mellitus and risk of Alzheimer disease. Journal of Alzheimer's Disease : Jad. 7: 81-4. PMID 15750216 DOI: 10.3233/JAD-2005-7108  0.789
2005 Atwood CS, Smith MA, Bowen RL. Feedback on a feedback loop: the hypothalamic-pituitary-gonadal axis. Journal of Alzheimer's Disease : Jad. 7: 1-2. PMID 15750209 DOI: 10.3233/Jad-2005-7101  0.773
2005 Casadesus G, Atwood CS, Zhu X, Hartzler AW, Webber KM, Perry G, Bowen RL, Smith MA. Evidence for the role of gonadotropin hormones in the development of Alzheimer disease. Cellular and Molecular Life Sciences : Cmls. 62: 293-8. PMID 15723165 DOI: 10.1007/S00018-004-4384-0  0.851
2005 Liu Q, Smith MA, Avilá J, DeBernardis J, Kansal M, Takeda A, Zhu X, Nunomura A, Honda K, Moreira PI, Oliveira CR, Santos MS, Shimohama S, Aliev G, de la Torre J, et al. Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations. Free Radical Biology & Medicine. 38: 746-54. PMID 15721985 DOI: 10.1016/J.Freeradbiomed.2004.11.005  0.834
2005 Smith MA, Nunomura A, Lee HG, Zhu X, Moreira PI, Avila J, Perry G. Chronological primacy of oxidative stress in Alzheimer disease. Neurobiology of Aging. 26: 579-80. PMID 15708430 DOI: 10.1016/j.neurobiolaging.2004.09.021  0.853
2005 Bowen RL, Martins RN, Gregory CW, Smith MA, Atwood CS. Dementia and testosterone levels in men. Jama. 293: 551; author reply 55. PMID 15687304 DOI: 10.1001/Jama.293.5.551-B  0.747
2005 Tamagno E, Parola M, Bardini P, Piccini A, Borghi R, Guglielmotto M, Santoro G, Davit A, Danni O, Smith MA, Perry G, Tabaton M. Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways. Journal of Neurochemistry. 92: 628-36. PMID 15659232 DOI: 10.1111/j.1471-4159.2004.02895.x  0.797
2005 Webber KM, Smith MA, Lee HG, Harris PL, Moreira P, Perry G, Zhu X. Mitogen- and stress-activated protein kinase 1: convergence of the ERK and p38 pathways in Alzheimer's disease. Journal of Neuroscience Research. 79: 554-60. PMID 15635602 DOI: 10.1002/jnr.20380  0.845
2005 Liu Q, Lee HG, Honda K, Siedlak SL, Harris PL, Cash AD, Zhu X, Avila J, Nunomura A, Takeda A, Smith MA, Perry G. Tau modifiers as therapeutic targets for Alzheimer's disease. Biochimica Et Biophysica Acta. 1739: 211-5. PMID 15615639 DOI: 10.1016/J.Bbadis.2004.06.021  0.872
2005 Moreira PI, Siedlak SL, Aliev G, Zhu X, Cash AD, Smith MA, Perry G. Oxidative stress mechanisms and potential therapeutics in Alzheimer disease. Journal of Neural Transmission (Vienna, Austria : 1996). 112: 921-32. PMID 15583960 DOI: 10.1007/S00702-004-0242-8  0.838
2005 Baykal A, arigul FS, Suleymanla G, Moreira PI, Perry G, Smith MA, Aliciguzel Y. Ciprofloxacin Does Not Exert Nephrotoxicity in Rats American Journal of Infectious Diseases. 1: 145-148. DOI: 10.3844/Ajidsp.2005.145.148  0.765
2005 Ashford JW, Crutcher KA, Robinson SR, Smith MA. Foreword: Challenging views of Alzheimer's disease – 2004 Journal of Alzheimer's Disease. 7: 233-233. DOI: 10.3233/Jad-2005-7305  0.598
2005 Honda K, Moreira PI, Liu Q, Siedlak SL, Zhu X, Smith MA, Perry G. Redox active iron at the center of oxidative stress in Alzheimer disease Letters in Drug Design and Discovery. 2: 479-482. DOI: 10.2174/1570180054771545  0.83
2005 Moreira P, Honda K, Liu Q, Aliev G, Oliveira C, Santos M, Zhu X, Smith M, Perry G. Alzheimers Disease and Oxidative Stress: The Old Problem Remains Unsolved Current Medicinal Chemistry-Central Nervous System Agents. 5: 51-62. DOI: 10.2174/1568015053202714  0.834
2005 Smith MA, Perry G. Role of Amyloid-β in Alzheimer's Disease International Journal of Experimental Pathology. 86: 131-131. DOI: 10.1111/j.0959-9673.2005.00437.x  0.647
2005 Rajendran R, Ren M, Casadesus G, Smith MA, Perry G, Huang E, Ong WY, Halliwell B, Watt F. Nuclear microscopy of diffuse plaques in the brains of transgenic mice Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions With Materials and Atoms. 231: 326-332. DOI: 10.1016/j.nimb.2005.01.078  0.789
2005 Aliev G, Perry G, Liu J, Smith MA, Chen SG, Ames BN, de la Torre JC. [P-074]: The primary pathogenetic role of vascular contains vasoactive substances, hypoperfusion, mitochondria failure and oxidative stress in aging and Alzheimer disease Alzheimer's & Dementia. 1: S31-S31. DOI: 10.1016/J.Jalz.2005.06.148  0.766
2005 Perry G, Smith MA. Introduction: Imaging in Alzheimer's disease Microscopy Research and Technique. 67: 113-113. DOI: 10.1002/jemt.20201  0.659
2004 Sayre LM, Harris PL, Perry G, Smith MA. In situ localization of nonenzymatic peroxidase-like activity of tissue-bound transition metals. Current Protocols in Toxicology / Editorial Board, Mahin D. Maines (Editor-in-Chief) ... [Et Al.]. Unit17.4. PMID 23045100 DOI: 10.1002/0471140856.Tx1704S20  0.748
2004 Aliev G, Smith MA, de la Torre JC, Perry G. Mitochondria as a primary target for vascular hypoperfusion and oxidative stress in Alzheimer's disease. Mitochondrion. 4: 649-63. PMID 16120422 DOI: 10.1016/j.mito.2004.07.018  0.781
2004 Avila J, Pérez M, Lucas JJ, Gómez-Ramos A, Santa María I, Moreno F, Smith M, Perry G, Hernández F. Assembly in vitro of tau protein and its implications in Alzheimer's disease. Current Alzheimer Research. 1: 97-101. PMID 15975073 DOI: 10.2174/1567205043332207  0.636
2004 Aliev G, Castellani RJ, Petersen RB, Burnstock G, Perry G, Smith MA. Pathobiology of familial hypercholesterolemic atherosclerosis. Journal of Submicroscopic Cytology and Pathology. 36: 225-40. PMID 15906597  0.745
2004 Moreira PI, Smith MA, Zhu X, Santos MS, Oliveira CR, Perry G. Therapeutic potential of oxidant mechanisms in Alzheimer's disease. Expert Review of Neurotherapeutics. 4: 995-1004. PMID 15853526 DOI: 10.1586/14737175.4.6.995  0.869
2004 Casadesus G, Shukitt-Hale B, Stellwagen HM, Zhu X, Lee HG, Smith MA, Joseph JA. Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats. Nutritional Neuroscience. 7: 309-16. PMID 15682927 DOI: 10.1080/10284150400020482  0.779
2004 Zhu X, Smith MA, Perry G, Aliev G. Mitochondrial failures in Alzheimer's disease. American Journal of Alzheimer's Disease and Other Dementias. 19: 345-52. PMID 15633943 DOI: 10.1177/153331750401900611  0.85
2004 Liu Q, Xie F, Siedlak SL, Nunomura A, Honda K, Moreira PI, Zhua X, Smith MA, Perry G. Neurofilament proteins in neurodegenerative diseases. Cellular and Molecular Life Sciences : Cmls. 61: 3057-75. PMID 15583867 DOI: 10.1007/S00018-004-4268-8  0.829
2004 Lee HG, Moreira PI, Zhu X, Smith MA, Perry G. Staying connected: synapses in Alzheimer disease. The American Journal of Pathology. 165: 1461-4. PMID 15509517 DOI: 10.1016/S0002-9440(10)63404-9  0.814
2004 Moreira PI, Liu Q, Honda K, Smith MA, Santos MS, Oliveira CR. Is intraneuronal amyloid beta-peptide accumulation the trigger of Alzheimer's disease pathophysiology? Journal of Alzheimer's Disease : Jad. 6: 433-4; discussion 44. PMID 15495345 DOI: 10.3233/Jad-2004-6411  0.845
2004 Casadesus G, Zhu X, Atwood CS, Webber KM, Perry G, Bowen RL, Smith MA. Beyond estrogen: targeting gonadotropin hormones in the treatment of Alzheimer's disease. Current Drug Targets. Cns and Neurological Disorders. 3: 281-5. PMID 15379604 DOI: 10.2174/1568007043337265  0.857
2004 Nunomura A, Chiba S, Lippa CF, Cras P, Kalaria RN, Takeda A, Honda K, Smith MA, Perry G. Neuronal RNA oxidation is a prominent feature of familial Alzheimer's disease. Neurobiology of Disease. 17: 108-13. PMID 15350971 DOI: 10.1016/J.Nbd.2004.06.003  0.838
2004 Takeda A, Itoyama Y, Kimpara T, Zhu X, Avila J, Dwyer BE, Perry G, Smith MA. Heme catabolism and heme oxygenase in neurodegenerative disease. Antioxidants & Redox Signaling. 6: 888-94. PMID 15345149 DOI: 10.1089/Ars.2004.6.888  0.847
2004 Seyidova D, Aliyev A, Rzayev N, Obrenovich M, Lamb BT, Smith MA, de la Torre JC, Perry G, Aliev G. The role of nitric oxide in the pathogenesis of brain lesions during the development of Alzheimer's disease. In Vivo (Athens, Greece). 18: 325-33. PMID 15341188  0.793
2004 Drew KL, Harris MB, LaManna JC, Smith MA, Zhu XW, Ma YL. Hypoxia tolerance in mammalian heterotherms. The Journal of Experimental Biology. 207: 3155-62. PMID 15299037 DOI: 10.1242/Jeb.01114  0.773
2004 Zhu X, Webber KM, Casadesus G, Raina AK, Lee HG, Marlatt M, Hartzler A, Atwood CS, Perry G, Smith MA. Mitotic and gender parallels in Alzheimer disease: therapeutic opportunities. Current Drug Targets. 5: 559-63. PMID 15270202 DOI: 10.2174/1389450043345317  0.856
2004 Aliyev A, Seyidova D, Rzayev N, Obrenovich ME, Lamb BT, Chen SG, Smith MA, Perry G, de la Torre JC, Aliev G. Is nitric oxide a key target in the pathogenesis of brain lesions during the development of Alzheimer's disease? Neurological Research. 26: 547-53. PMID 15265272 DOI: 10.1179/01610425017613  0.824
2004 Ma YL, Rice ME, Chao ML, Rivera PM, Zhao HW, Ross AP, Zhu X, Smith MA, Drew KL. Ascorbate distribution during hibernation is independent of ascorbate redox state. Free Radical Biology & Medicine. 37: 511-20. PMID 15256222 DOI: 10.1016/j.freeradbiomed.2004.04.025  0.78
2004 Lee HG, Casadesus G, Zhu X, Takeda A, Perry G, Smith MA. Challenging the amyloid cascade hypothesis: senile plaques and amyloid-beta as protective adaptations to Alzheimer disease. Annals of the New York Academy of Sciences. 1019: 1-4. PMID 15246983 DOI: 10.1196/Annals.1297.001  0.841
2004 Castellani RJ, Honda K, Zhu X, Cash AD, Nunomura A, Perry G, Smith MA. Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease. Ageing Research Reviews. 3: 319-26. PMID 15231239 DOI: 10.1016/j.arr.2004.01.002  0.839
2004 Hasegawa T, Matsuzaki M, Takeda A, Kikuchi A, Akita H, Perry G, Smith MA, Itoyama Y. Accelerated alpha-synuclein aggregation after differentiation of SH-SY5Y neuroblastoma cells. Brain Research. 1013: 51-9. PMID 15196967 DOI: 10.1016/J.Brainres.2004.04.018  0.656
2004 Webber KM, Bowen R, Casadesus G, Perry G, Atwood CS, Smith MA. Gonadotropins and Alzheimer's disease: the link between estrogen replacement therapy and neuroprotection. Acta Neurobiologiae Experimentalis. 64: 113-8. PMID 15190686  0.828
2004 Raina AK, Zhu X, Smith MA. Alzheimer's disease and the cell cycle. Acta Neurobiologiae Experimentalis. 64: 107-12. PMID 15190685  0.852
2004 Lee HG, Zhu X, O'Neill MJ, Webber K, Casadesus G, Marlatt M, Raina AK, Perry G, Smith MA. The role of metabotropic glutamate receptors in Alzheimer's disease. Acta Neurobiologiae Experimentalis. 64: 89-98. PMID 15190683  0.851
2004 Marlatt M, Lee HG, Perry G, Smith MA, Zhu X. Sources and mechanisms of cytoplasmic oxidative damage in Alzheimer's disease. Acta Neurobiologiae Experimentalis. 64: 81-7. PMID 15190682  0.849
2004 Gómez-Ramos A, Smith MA, Perry G, Avila J. Tau phosphorylation and assembly. Acta Neurobiologiae Experimentalis. 64: 33-9. PMID 15190678  0.617
2004 Castellani RJ, Perry G, Smith MA. Prion disease and Alzheimer's disease: pathogenic overlap. Acta Neurobiologiae Experimentalis. 64: 11-7. PMID 15190676  0.796
2004 Castellani RJ, Smith MA, Perry G, Friedland RP. Cerebral amyloid angiopathy: major contributor or decorative response to Alzheimer's disease pathogenesis. Neurobiology of Aging. 25: 599-602; discussion . PMID 15172735 DOI: 10.1016/J.Neurobiolaging.2003.12.019  0.839
2004 Zhu X, Wang Y, Ogawa O, Lee HG, Raina AK, Siedlak SL, Harris PL, Fujioka H, Shimohama S, Tabaton M, Atwood CS, Petersen RB, Perry G, Smith MA. Neuroprotective properties of Bcl-w in Alzheimer disease. Journal of Neurochemistry. 89: 1233-40. PMID 15147516 DOI: 10.1111/J.1471-4159.2004.02416.X  0.851
2004 Dozza B, Smith MA, Perry G, Tabaton M, Strocchi P. Regulation of glycogen synthase kinase-3beta by products of lipid peroxidation in human neuroblastoma cells. Journal of Neurochemistry. 89: 1224-32. PMID 15147515 DOI: 10.1111/j.1471-4159.2004.02413.x  0.754
2004 Dwyer BE, Raina AK, Perry G, Smith MA. Homocysteine and Alzheimer's disease: a modifiable risk? Free Radical Biology & Medicine. 36: 1471-5. PMID 15135184 DOI: 10.1016/J.Freeradbiomed.2004.03.009  0.826
2004 Honda K, Casadesus G, Petersen RB, Perry G, Smith MA. Oxidative stress and redox-active iron in Alzheimer's disease. Annals of the New York Academy of Sciences. 1012: 179-82. PMID 15105265 DOI: 10.1196/Annals.1306.015  0.85
2004 Casadesus G, Smith MA, Zhu X, Aliev G, Cash AD, Honda K, Petersen RB, Perry G. Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen species. Journal of Alzheimer's Disease : Jad. 6: 165-9. PMID 15096700 DOI: 10.3233/Jad-2004-6208  0.852
2004 Lee HG, Casadesus G, Zhu X, Joseph JA, Perry G, Smith MA. Perspectives on the amyloid-beta cascade hypothesis. Journal of Alzheimer's Disease : Jad. 6: 137-45. PMID 15096697 DOI: 10.3233/Jad-2004-6205  0.844
2004 Perry G, Smith MA. Oxidative Stress in Aging and Neurodegenerative Diseases: From Biology to Therapy, Perugia, Italy, May 2003 Journal of Alzheimer's Disease. 6: 115-115. PMID 15096693 DOI: 10.3233/Jad-2004-6201  0.649
2004 Zhu X, Raina AK, Lee HG, Casadesus G, Smith MA, Perry G. Oxidative stress signalling in Alzheimer's disease. Brain Research. 1000: 32-9. PMID 15053949 DOI: 10.1016/J.Brainres.2004.01.012  0.856
2004 Zhu X, Raina AK, Perry G, Smith MA. Alzheimer's disease: the two-hit hypothesis. The Lancet. Neurology. 3: 219-26. PMID 15039034 DOI: 10.1016/S1474-4422(04)00707-0  0.853
2004 Vitali A, Piccini A, Borghi R, Fornaro P, Siedlak SL, Smith MA, Gambetti P, Ghetti B, Tabaton M. Soluble amyloid beta-protein is increased in frontotemporal dementia with tau gene mutations. Journal of Alzheimer's Disease : Jad. 6: 45-51. PMID 15004327 DOI: 10.3233/Jad-2004-6106  0.797
2004 Zhu X, McShea A, Harris PL, Raina AK, Castellani RJ, Funk JO, Shah S, Atwood C, Bowen R, Bowser R, Morelli L, Perry G, Smith MA. Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer's disease. Journal of Neuroscience Research. 75: 698-703. PMID 14991845 DOI: 10.1002/Jnr.20028  0.843
2004 Ghanbari HA, Ghanbari K, Harris PL, Jones PK, Kubat Z, Castellani RJ, Wolozin BL, Smith MA, Perry G. Oxidative damage in cultured human olfactory neurons from Alzheimer's disease patients. Aging Cell. 3: 41-4. PMID 14965355 DOI: 10.1111/J.1474-9728.2004.00083.X  0.854
2004 Lee HG, Ogawa O, Zhu X, O'Neill MJ, Petersen RB, Castellani RJ, Ghanbari H, Perry G, Smith MA. Aberrant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer's disease. Acta Neuropathologica. 107: 365-71. PMID 14872255 DOI: 10.1007/S00401-004-0820-8  0.844
2004 Bowen RL, Verdile G, Liu T, Parlow AF, Perry G, Smith MA, Martins RN, Atwood CS. Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition. The Journal of Biological Chemistry. 279: 20539-45. PMID 14871891 DOI: 10.1074/Jbc.M311993200  0.82
2004 Liu T, Perry G, Chan HW, Verdile G, Martins RN, Smith MA, Atwood CS. Amyloid-beta-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression. Journal of Neurochemistry. 88: 554-63. PMID 14720205 DOI: 10.1046/J.1471-4159.2003.02196.X  0.808
2004 Atwood CS, Perry G, Zeng H, Kato Y, Jones WD, Ling KQ, Huang X, Moir RD, Wang D, Sayre LM, Smith MA, Chen SG, Bush AI. Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta. Biochemistry. 43: 560-8. PMID 14717612 DOI: 10.1021/Bi0358824  0.801
2004 Zhu X, Perry G, Smith MA. Amyotrophic lateral sclerosis: a novel hypothesis involving a gained 'loss of function' in the JNK/SAPK pathway. Redox Report : Communications in Free Radical Research. 8: 129-33. PMID 12935309 DOI: 10.1179/135100003225001494  0.804
2004 Cash A, Smith M, Perry G. Oxidative Stress Mechanisms and Potential Therapeutic Modalities in Alzheimer Disease Medicinal Chemistry Reviews - Online. 1: 19-23. DOI: 10.2174/1567203043480386  0.803
2004 Honda K, Perry G, Smith MA. Metal Ions and Neurodegenerative Diseases Paolo Zatta, Editor. World Scientific Publishing Co. Pte. Ltd, Singapore, 2004, pp 400 Aging Cell. 3: 85-85. DOI: 10.1111/j.1474-9728.2004.00090.x  0.791
2004 Honda K, Smith MA, Nunomura A, Harris PL, Siedlak SL, Perry G. P4-250 Redox-active iron oxidizes ribosomal RNa in neurons vulnerable to Alzheimer's disease Neurobiology of Aging. 25: S546. DOI: 10.1016/S0197-4580(04)81808-6  0.83
2004 Vidal R, Ghetti B, Delisle MB, Rascol O, Perry G, Smith MA. P4-242 Oxidative damage in ferritin-induced neurodegeneration Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81800-1  0.604
2004 Lee H, Zhu X, O'Neill MJ, Perry G, Smith MA. P3-306 Differential expression of metabotrophic glutamate receptors (MGlurs) in Alzheimer disease Neurobiology of Aging. 25: S442. DOI: 10.1016/S0197-4580(04)81456-8  0.807
2004 Liu Q, Smith MA, Siedlak SL, Harris PL, Maccioni RB, Sayre LM, Perry G. P3-275 Phosphorylation dependent control of oxidative modification in Alzheimer disease Neurobiology of Aging. 25: S432-S433. DOI: 10.1016/S0197-4580(04)81425-8  0.838
2004 Raina AK, Zhu X, Adam C, Sayre L, Perry G, Smith MA. P3-219 Acetylation: a novel posttranslational modification in Alzheimer disease Neurobiology of Aging. 25: S417. DOI: 10.1016/S0197-4580(04)81369-1  0.834
2004 Friedland RP, Shi J, Smith MA, Perry G, Sparks DL. P2-003 Cholesterol feeding enhances cerebral amyloid beta pathology in beagles Neurobiology of Aging. 25: S224. DOI: 10.1016/S0197-4580(04)80751-6  0.753
2004 Casadesus G, Webber KM, Ogawa O, Bowen RL, Atwood CS, Perry G, Smith MA. P1-369 Modulation of cognition and amyloid load in the aged SWAβPP transgenic mouse by luprolide acetate, a GNRH agonist: targeting luteinizing hormone as a novel treatment for AD Neurobiology of Aging. 25: S203. DOI: 10.1016/S0197-4580(04)80681-X  0.806
2004 Strocchi P, Smith MA, Perry G, Tabaton M, Dozza B. P1-286 Glycogen synthase kinase-3β activity is regulated by products of lipid peroxidation: relevance to Alzheimer disease Neurobiology of Aging. 25: S177. DOI: 10.1016/S0197-4580(04)80599-2  0.783
2004 Zhu X, Lee H, Perry G, Smith MA. P1-266 The critical role of the ERK pathway in the pathogenesis of Alzheimer's disease Neurobiology of Aging. 25: S172. DOI: 10.1016/S0197-4580(04)80579-7  0.834
2004 Smith MA, Raina AK, Perry G, Zhu X. S4-02-01 Alzheimer disease: the two hit hypothesis Neurobiology of Aging. 25: S68. DOI: 10.1016/S0197-4580(04)80231-8  0.846
2004 Aliev G, Siedlak SL, Smith MA, Aliyev A, Rzayev N, de la Torre JC, Perry G. O3-04-07 Vascular and metabolic failure in Alzheimer disease Neurobiology of Aging. 25: S61. DOI: 10.1016/S0197-4580(04)80204-5  0.764
2004 Zhu X, McShea A, Harris PL, Raina AK, Castellani RJ, Funk J, Shah S, Atwood CS, Bowen R, Bowser R, Morelli L, Perry G, Smith MA. O2-04-07 Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1 associated regulator of cyclin B, in Alzheimer disease Neurobiology of Aging. 25: S40. DOI: 10.1016/S0197-4580(04)80133-7  0.807
2004 Atwood CS, Liu T, Smith MA, Martins RN, Bowen RL, Verdile G. O2-04-06 17β-Estradiol and luteinizing hormone modulate the expression of luteinizing hormone receptors in neuroblastoma cells Neurobiology of Aging. 25: S40. DOI: 10.1016/S0197-4580(04)80132-5  0.729
2004 Aliev G, Seyidova D, Smith MA, Perry G, de la Torre JC. VASCULAR HYPOPERFUSION AND MITOCHONDRIA ABNORMALITY INDUCE OXIDATIVE STRESS THAT APPEARED TO BE A KEY FACTOR FOR THE DEVELOPMENT OF ALZHEIMER DISEASE Cardiovascular Pathology. 13: 26-27. DOI: 10.1016/j.carpath.2004.03.072  0.748
2004 Bowen R, Atwood CS, Perry G, Smith MA. Mechanisms Involved in Gender Differences in Alzheimer's Disease: The Role of Leuteinizing and Follicle Stimulating Hormones Principles of Gender-Specific Medicine. 2: 1234-1237. DOI: 10.1016/B978-012440905-7/50388-1  0.841
2004 Martin A, Smith MA, Perry G, Joseph J. Nutritional Antioxidants, Vitamins, Cognition, and Neurodegenerative Disease Principles of Gender-Specific Medicine. 813-823. DOI: 10.1016/B978-012440905-7/50345-5  0.695
2003 Raina AK, Zhu X, Shimohama S, Perry G, Smith MA. Tipping the apoptotic balance in Alzheimer's disease: the abortosis concept. Cell Biochemistry and Biophysics. 39: 249-55. PMID 14716079 DOI: 10.1385/Cbb:39:3:249  0.835
2003 Aliev G, Smith MA, Obrenovich ME, de la Torre JC, Perry G. Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Azheimer disease. Neurotoxicity Research. 5: 491-504. PMID 14715433 DOI: 10.1007/Bf03033159  0.845
2003 Aliev G, Obrenovich ME, Seyidova D, Rzayev NM, Aliyev AS, Raina AK, Lamanna JC, Smith MA, Perry G. X-ray contrast media induce aortic endothelial damage, which can be prevented with prior heparin treatment. Journal of Submicroscopic Cytology and Pathology. 35: 253-66. PMID 14690173  0.765
2003 Lee HG, Petersen RB, Zhu X, Honda K, Aliev G, Smith MA, Perry G. Will preventing protein aggregates live up to its promise as prophylaxis against neurodegenerative diseases? Brain Pathology (Zurich, Switzerland). 13: 630-8. PMID 14655766 DOI: 10.1111/J.1750-3639.2003.Tb00491.X  0.835
2003 Zhu X, Raina AK, Lee HG, Chao M, Nunomura A, Tabaton M, Petersen RB, Perry G, Smith MA. Oxidative stress and neuronal adaptation in Alzheimer disease: the role of SAPK pathways. Antioxidants & Redox Signaling. 5: 571-6. PMID 14580312 DOI: 10.1089/152308603770310220  0.856
2003 Perry G, Nunomura A, Raina AK, Aliev G, Siedlak SL, Harris PL, Casadesus G, Petersen RB, Bligh-Glover W, Balraj E, Petot GJ, Smith MA. A metabolic basis for Alzheimer disease. Neurochemical Research. 28: 1549-52. PMID 14570400 DOI: 10.1023/A:1025678510480  0.851
2003 Aliev G, Seyidova D, Lamb BT, Obrenovich ME, Siedlak SL, Vinters HV, Friedland RP, LaManna JC, Smith MA, Perry G. Mitochondria and vascular lesions as a central target for the development of Alzheimer's disease and Alzheimer disease-like pathology in transgenic mice. Neurological Research. 25: 665-74. PMID 14503022 DOI: 10.1179/016164103101201977  0.845
2003 Atwood CS, Bowen RL, Smith MA, Perry G. Cerebrovascular requirement for sealant, anti-coagulant and remodeling molecules that allow for the maintenance of vascular integrity and blood supply. Brain Research. Brain Research Reviews. 43: 164-78. PMID 14499467 DOI: 10.1016/S0165-0173(03)00206-6  0.804
2003 Atwood CS, Obrenovich ME, Liu T, Chan H, Perry G, Smith MA, Martins RN. Amyloid-beta: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-beta. Brain Research. Brain Research Reviews. 43: 1-16. PMID 14499458 DOI: 10.1016/S0165-0173(03)00174-7  0.831
2003 Aliev G, Obrenovich ME, Smith MA, Perry G. Hypoperfusion, Mitochondria Failure, Oxidative Stress, and Alzheimer Disease. Journal of Biomedicine & Biotechnology. 2003: 162-163. PMID 12975531 DOI: 10.1155/S1110724303305029  0.84
2003 Perry G, Castellani RJ, Smith MA, Harris PL, Kubat Z, Ghanbari K, Jones PK, Cordone G, Tabaton M, Wolozin B, Ghanbari H. Oxidative damage in the olfactory system in Alzheimer's disease. Acta Neuropathologica. 106: 552-6. PMID 12955399 DOI: 10.1007/S00401-003-0761-7  0.854
2003 Liu Q, Raina AK, Smith MA, Sayre LM, Perry G. Hydroxynonenal, toxic carbonyls, and Alzheimer disease. Molecular Aspects of Medicine. 24: 305-13. PMID 12893008 DOI: 10.1016/S0098-2997(03)00025-6  0.852
2003 Ogawa O, Lee HG, Zhu X, Raina A, Harris PL, Castellani RJ, Perry G, Smith MA. Increased p27, an essential component of cell cycle control, in Alzheimer's disease. Aging Cell. 2: 105-10. PMID 12882323 DOI: 10.1046/J.1474-9728.2003.00042.X  0.857
2003 Kitamura Y, Tsuchiya D, Takata K, Shibagaki K, Taniguchi T, Smith MA, Perry G, Miki H, Takenawa T, Shimohama S. Possible involvement of Wiskott-Aldrich syndrome protein family in aberrant neuronal sprouting in Alzheimer's disease. Neuroscience Letters. 346: 149-52. PMID 12853106 DOI: 10.1016/S0304-3940(03)00506-8  0.743
2003 Zhu X, Sun Z, Lee HG, Siedlak SL, Perry G, Smith MA. Distribution, levels, and activation of MEK1 in Alzheimer's disease. Journal of Neurochemistry. 86: 136-42. PMID 12807433 DOI: 10.1046/J.1471-4159.2003.01820.X  0.835
2003 Matsubara E, Bryant-Thomas T, Pacheco Quinto J, Henry TL, Poeggeler B, Herbert D, Cruz-Sanchez F, Chyan YJ, Smith MA, Perry G, Shoji M, Abe K, Leone A, Grundke-Ikbal I, Wilson GL, et al. Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease. Journal of Neurochemistry. 85: 1101-8. PMID 12753069 DOI: 10.1046/J.1471-4159.2003.01654.X  0.842
2003 Tateyama M, Takeda A, Onodera Y, Matsuzaki M, Hasegawa T, Nunomura A, Hirai K, Perry G, Smith MA, Itoyama Y. Oxidative stress and predominant Abeta42(43) deposition in myopathies with rimmed vacuoles. Acta Neuropathologica. 105: 581-5. PMID 12734664 DOI: 10.1007/S00401-003-0685-2  0.786
2003 Bianco NR, Perry G, Smith MA, Templeton DJ, Montano MM. Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage. Molecular Endocrinology (Baltimore, Md.). 17: 1344-55. PMID 12714703 DOI: 10.1210/Me.2002-0382  0.563
2003 Cash AD, Aliev G, Siedlak SL, Nunomura A, Fujioka H, Zhu X, Raina AK, Vinters HV, Tabaton M, Johnson AB, Paula-Barbosa M, Avíla J, Jones PK, Castellani RJ, Smith MA, et al. Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation. The American Journal of Pathology. 162: 1623-7. PMID 12707046 DOI: 10.1016/S0002-9440(10)64296-4  0.849
2003 Veurink G, Liu D, Taddei K, Perry G, Smith MA, Robertson TA, Hone E, Groth DM, Atwood CS, Martins RN. Reduction of inclusion body pathology in ApoE-deficient mice fed a combination of antioxidants. Free Radical Biology & Medicine. 34: 1070-7. PMID 12684092 DOI: 10.1016/S0891-5849(03)00042-X  0.795
2003 Ogawa O, Zhu X, Lee HG, Raina A, Obrenovich ME, Bowser R, Ghanbari HA, Castellani RJ, Perry G, Smith MA. Ectopic localization of phosphorylated histone H3 in Alzheimer's disease: a mitotic catastrophe? Acta Neuropathologica. 105: 524-8. PMID 12677454 DOI: 10.1007/S00401-003-0684-3  0.845
2003 Raina AK, Hochman A, Ickes H, Zhu X, Ogawa O, Cash AD, Shimohama S, Perry G, Smith MA. Apoptotic promoters and inhibitors in Alzheimer's disease: Who wins out? Progress in Neuro-Psychopharmacology & Biological Psychiatry. 27: 251-4. PMID 12657364 DOI: 10.1016/S0278-5846(03)00020-4  0.848
2003 Zhu X, Ogawa O, Wang Y, Perry G, Smith MA. JKK1, an upstream activator of JNK/SAPK, is activated in Alzheimer's disease. Journal of Neurochemistry. 85: 87-93. PMID 12641730 DOI: 10.1046/J.1471-4159.2003.01645.X  0.85
2003 Dong J, Atwood CS, Anderson VE, Siedlak SL, Smith MA, Perry G, Carey PR. Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence. Biochemistry. 42: 2768-73. PMID 12627941 DOI: 10.1021/Bi0272151  0.825
2003 Smith MA, Perry G, Atwood CS, Bowen RL. Estrogen replacement and risk of Alzheimer disease. Jama. 289: 1100; author reply 1. PMID 12622570 DOI: 10.1001/Jama.289.9.1100-A  0.823
2003 Gómez-Ramos A, Díaz-Nido J, Smith MA, Perry G, Avila J. Effect of the lipid peroxidation product acrolein on tau phosphorylation in neural cells. Journal of Neuroscience Research. 71: 863-70. PMID 12605413 DOI: 10.1002/jnr.10525  0.658
2003 Atwood CS, Perry G, Smith MA. Cerebral hemorrhage and amyloid-beta. Science (New York, N.Y.). 299: 1014; author reply 1. PMID 12586924 DOI: 10.1126/science.299.5609.1014a  0.776
2003 Perry G, Taddeo MA, Petersen RB, Castellani RJ, Harris PL, Siedlak SL, Cash AD, Liu Q, Nunomura A, Atwood CS, Smith MA. Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 16: 77-81. PMID 12572666 DOI: 10.1023/A:1020731021276  0.846
2003 Takata K, Kitamura Y, Kakimura J, Shibagaki K, Tsuchiya D, Taniguchi T, Smith MA, Perry G, Shimohama S. Role of high mobility group protein-1 (HMG1) in amyloid-beta homeostasis. Biochemical and Biophysical Research Communications. 301: 699-703. PMID 12565837 DOI: 10.1016/S0006-291X(03)00024-X  0.712
2002 Kakimura JI, Kitamura Y, Takata K, Umeki M, Suzuki S, Shibagaki K, Taniguchi T, Nomura Y, Gebicke-Haerter PJ, Smith MA, Perry G, Shimohama S. Microglial activation and amyloid-β clearance induced by exogenous heat-shock proteins. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 601-603. PMID 29470936 DOI: 10.1096/fj.01-0530fje  0.468
2002 Ogawa O, Zhu X, Perry G, Smith MA. Mitochondrial abnormalities and oxidative imbalance in neurodegenerative disease. Science of Aging Knowledge Environment : Sage Ke. 2002: pe16. PMID 14603007 DOI: 10.1126/Sageke.2002.41.Pe16  0.807
2002 Reddy VP, Obrenovich ME, Atwood CS, Perry G, Smith MA. Involvement of Maillard reactions in Alzheimer disease. Neurotoxicity Research. 4: 191-209. PMID 12829400 DOI: 10.1080/1029840290007321  0.843
2002 Lee HG, Zhu X, Ghanbari HA, Ogawa O, Raina AK, O'Neill MJ, Perry G, Smith MA. Differential regulation of glutamate receptors in Alzheimer's disease. Neuro-Signals. 11: 282-92. PMID 12566929 DOI: 10.1159/000067427  0.836
2002 Zhu X, Lee HG, Raina AK, Perry G, Smith MA. The role of mitogen-activated protein kinase pathways in Alzheimer's disease. Neuro-Signals. 11: 270-81. PMID 12566928 DOI: 10.1159/000067426  0.839
2002 Perry G, Cash AD, Smith MA. Alzheimer Disease and Oxidative Stress. Journal of Biomedicine & Biotechnology. 2: 120-123. PMID 12488575 DOI: 10.1155/S1110724302203010  0.814
2002 Takata K, Kitamura Y, Kakimura J, Shibagaki K, Taniguchi T, Gebicke-Haerter PJ, Smith MA, Perry G, Shimohama S. Possible protective mechanisms of heme oxygenase-1 in the brain. Annals of the New York Academy of Sciences. 977: 501-6. PMID 12480792 DOI: 10.1111/J.1749-6632.2002.Tb04857.X  0.64
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