David H. Kwan
Affiliations: | 2015- | Biology | Concordia University (Canada), Montreal, QC, Canada |
Area:
Synthetic BiologyGoogle:
"David Kwan"Parents
Sign in to add mentor| Peter F. Leadlay | grad student | 2005-2009 | Cambridge |
| Stephen G. Withers | post-doc | 2009-2015 | UBC |
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Publications
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| Ouadhi S, López DMV, Mohideen FI, et al. (2022) Engineering the Enzyme Toolbox to Tailor Glycosylation in Small Molecule Natural Products and Protein Biologics. Protein Engineering, Design & Selection : Peds |
| Zhao J, Si Y, Han Z, et al. (2020) Corrigendum: Facile Formation of β-thioGlcNAc Linkages to Thiol-Containing Sugars, Peptides, and Proteins using a Mutant GH20 Hexosaminidase. Angewandte Chemie (International Ed. in English). 59: 8752 |
| Soroko M, Kwan DH. (2020) Enzymatic Synthesis of a Fluorogenic Reporter Substrate and the Development of a High-Throughput Assay for Fucosyltransferase VIII Provide a Toolkit to Probe and Inhibit Core Fucosylation. Biochemistry |
| Leclerc LMY, Soffer G, Kwan DH, et al. (2019) A fucosyltransferase inhibition assay using image-analysis and digital microfluidics. Biomicrofluidics. 13: 034106 |
| Zhang X, Chen F, Petrella A, et al. (2019) A high-throughput glycosyltransferase inhibition assay to identify molecules targeting fucosylation in cancer cell-surface modification. Acs Chemical Biology |
| Tegl G, Hanson J, Chen HM, et al. (2018) Facile Formation of β-thioGlcNAc Linkages to Thiol-Containing Sugars, Peptides, and Proteins using a Mutant GH20 Hexosaminidase. Angewandte Chemie (International Ed. in English) |
| Kwan DH. (2017) Structure-Guided Directed Evolution of Glycosidases: A Case Study in Engineering a Blood Group Antigen-Cleaving Enzyme. Methods in Enzymology. 597: 25-53 |
| Kwan DH, Jin Y, Jiang J, et al. (2016) Chemoenzymatic synthesis of 6-phospho-cyclophellitol as a novel probe of 6-phospho-β-glucosidases. Febs Letters |
| Volkers G, Worrall LJ, Kwan DH, et al. (2015) Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation. Nature Structural & Molecular Biology. 22: 627-35 |
| Kwan DH, Ernst S, Kötzler MP, et al. (2015) Chemoenzymatic Synthesis of a Type 2 Blood Group A Tetrasaccharide and Development of High-throughput Assays Enables a Platform for Screening Blood Group Antigen-cleaving Enzymes. Glycobiology. 25: 806-11 |