Lance M. Hellman, Ph.D.
Affiliations: | University of Kentucky, Lexington, KY |
Area:
Protein-nucleic acid interactionsGoogle:
"Lance Hellman"Parents
Sign in to add mentor| Michael G. Fried | grad student | 2011 | University of Kentucky | |
| (The interaction of O6-alkylguanine-DNA alkyltransferase with human telomeric G-quadruplex DNAs containing O6-methylguanine adducts.) | ||||
| Brian M. Baker | post-doc | 2013 | Notre Dame | |
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Publications
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| Singh NK, Alonso JA, Devlin JR, et al. (2022) A class-mismatched TCR bypasses MHC restriction via an unorthodox but fully functional binding geometry. Nature Communications. 13: 7189 |
| Liu C, Liu H, Dasgupta M, et al. (2022) Validation and promise of a TCR mimic antibody for cancer immunotherapy of hepatocellular carcinoma. Scientific Reports. 12: 12068 |
| Ma J, Ayres CM, Hellman LM, et al. (2021) Dynamic allostery controls the peptide sensitivity of the Ly49C natural killer receptor. The Journal of Biological Chemistry. 100686 |
| Smith AR, Alonso JA, Ayres CM, et al. (2021) Structurally silent peptide anchor modifications allosterically modulate T cell recognition in a receptor-dependent manner. Proceedings of the National Academy of Sciences of the United States of America. 118 |
| Singh NK, Alonso JA, Harris DT, et al. (2020) An Engineered T Cell Receptor Variant Realizes the Limits of Functional Binding Modes. Biochemistry |
| Ayres CM, Abualrous ET, Bailey A, et al. (2019) Dynamically Driven Allostery in MHC Proteins: Peptide-Dependent Tuning of Class I MHC Global Flexibility. Frontiers in Immunology. 10: 966 |
| Hellman LM, Foley KC, Singh NK, et al. (2018) Improving T Cell Receptor On-Target Specificity via Structure-Guided Design. Molecular Therapy : the Journal of the American Society of Gene Therapy |
| Riley TP, Hellman LM, Gee MH, et al. (2018) T cell receptor cross-reactivity expanded by dramatic peptide-MHC adaptability. Nature Chemical Biology. 14: 934-942 |
| Spear TT, Wang Y, Smith TW, et al. (2018) Altered Peptide Ligands Impact the Diversity of Polyfunctional Phenotypes in T Cell Receptor Gene-Modified T Cells. Molecular Therapy : the Journal of the American Society of Gene Therapy |
| Moore T, Wagner CR, Scurti GM, et al. (2017) Correction to: Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells. Cancer Immunology, Immunotherapy : Cii |