Hai Yuan, Ph.D.
Affiliations: | 2006 | Northwestern University, Evanston, IL |
Area:
Organic, Synthetic, Bio-Organic, Medicinal Chemistry, Chemical BiologyGoogle:
"Hai Yuan"Parents
Sign in to add mentor| Richard B. Silverman | grad student | 2006 | Northwestern | |
| (Novel substrates and inhibitors of gamma-aminobutyric acid aminotransferase (GABA -AT): Design, synthesis, biological activities, and mechanistic studies.) | ||||
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Publications
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| Mao J, Yuan H, Wang Y, et al. (2010) Synthesis and antituberculosis activity of novel mefloquine-isoxazole carboxylic esters as prodrugs. Bioorganic & Medicinal Chemistry Letters. 20: 1263-8 |
| Mao J, Yuan H, Wang Y, et al. (2009) From serendipity to rational antituberculosis drug discovery of mefloquine-isoxazole carboxylic acid esters Journal of Medicinal Chemistry. 52: 6966-6978 |
| Yuan H, Silverman RB. (2007) Structural modifications of (1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxylic acid, a potent irreversible inhibitor of GABA aminotransferase. Bioorganic & Medicinal Chemistry Letters. 17: 1651-4 |
| Wang Z, Yuan H, Nikolic D, et al. (2006) (+/-)-(1S,2R,5S)-5-Amino-2-fluorocyclohex-3-enecarboxylic acid. A potent GABA aminotransferase inactivator that irreversibly inhibits via an elimination-aromatization pathway. Biochemistry. 45: 14513-22 |
| Yuan H, Silverman RB. (2006) New substrates and inhibitors of gamma-aminobutyric acid aminotransferase containing bioisosteres of the carboxylic acid group: design, synthesis, and biological activity. Bioorganic & Medicinal Chemistry. 14: 1331-8 |