Herschel V. Wade, Ph.D.

Affiliations: 
Biophysics and Biophysical Chemistry Johns Hopkins University School of Medicine, Baltimore, MD, United States 
 2000 University of California, San Francisco, San Francisco, CA 
Area:
molecular basis of the tissue-selectivity of hormones
Website:
http://biophysics.med.jhmi.edu/people/herschel-wade/
Google:
"Herschel V. Wade"
Bio:

https://www.hopkinsmedicine.org/profiles/results/directory/profile/6215496/herschel-wade

Parents

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Thomas S. Scanlan grad student 1994-2000 UCSF
 (Binding energy in antibody catalysis.)
William F. DeGrado post-doc 2000-2006 Penn
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Publications

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Moreno AT, Froehlig JR, Bachas S, et al. (2016) Solution-binding and structural analyses reveal potential multidrug resistance functions for SAV2435 and CTR107 and other GyrI-like proteins. Biochemistry
Gunio D, Froehlig J, Pappas K, et al. (2016) Solution-Binding and Molecular Docking Approaches Combine to Provide an Expanded View of Multidrug Recognition in the MDR Gene Regulator BmrR. Journal of Chemical Information and Modeling. 56: 377-89
Eginton C, Cressman WJ, Bachas S, et al. (2015) Allosteric coupling via distant disorder-to-order transitions. Journal of Molecular Biology. 427: 1695-704
Bachas S, Eginton C, Gunio D, et al. (2011) Structural contributions to multidrug recognition in the multidrug resistance (MDR) gene regulator, BmrR. Proceedings of the National Academy of Sciences of the United States of America. 108: 11046-51
Wade H, Stayrook SE, Degrado WF. (2006) The structure of a designed diiron(III) protein: implications for cofactor stabilization and catalysis. Angewandte Chemie (International Ed. in English). 45: 4951-4
Wei PP, Skulan AJ, Wade H, et al. (2005) Spectroscopic and computational studies of the de novo designed protein DF2t: correlation to the biferrous active site of ribonucleotide reductase and factors that affect O2 reactivity. Journal of the American Chemical Society. 127: 16098-106
Maglio O, Nastri F, Calhoun JR, et al. (2005) Artificial di-iron proteins: solution characterization of four helix bundles containing two distinct types of inter-helical loops. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 10: 539-49
Wade H, Scanlan TS. (2003) Binding and catalysis: a thermodynamic study on a catalytic antibody system. Chembiochem : a European Journal of Chemical Biology. 4: 537-40
Wade HV, Stayrook S, DeGrado WF. (2003) Structural analysis of a de novo designed metalloprotein Journal of Inorganic Biochemistry. 96: 246
Di Costanzo L, Wade H, Geremia S, et al. (2002) Toward the de novo design of a catalytically active helix bundle: a substrate-accessible carboxylate-bridged dinuclear metal center. Journal of the American Chemical Society. 123: 12749-57
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