Amanda J. Fusco, Ph.D.
Affiliations: | 2007 | Chemistry | University of California, San Diego, La Jolla, CA |
Area:
transcription, signaling, pre-mRNA splicing, mRNA transport, protein-protein, protein-DNA and protein-RNA interactionsGoogle:
"Amanda Fusco"Parents
Sign in to add mentor| Gourisankar Ghosh | grad student | 2007 | UCSD | |
| (NF-kappaB RelB /p52 heterodimer: Biogenesis and DNA recognition.) | ||||
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Publications
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| Fusco AJ, Mazumder A, Wang VY, et al. (2016) The NF-κB subunit RelB controls p100 processing by competing with the kinases NIK and IKK1 for binding to p100. Science Signaling. 9: ra96 |
| Tao Z, Fusco A, Huang DB, et al. (2014) p100/IκBδ sequesters and inhibits NF-κB through kappaBsome formation. Proceedings of the National Academy of Sciences of the United States of America. 111: 15946-51 |
| Polley S, Huang DB, Hauenstein AV, et al. (2013) A structural basis for IκB kinase 2 activation via oligomerization-dependent trans auto-phosphorylation. Plos Biology. 11: e1001581 |
| Polley S, Huang DB, Hauenstein AV, et al. (2013) X-ray crystal structure of human IKK2 in an active conformation Plos Biology |
| Ghosh G, Wang VY, Huang DB, et al. (2012) NF-κB regulation: lessons from structures. Immunological Reviews. 246: 36-58 |
| Fusco AJ, Huang DB, Miller D, et al. (2009) NF-kappaB p52:RelB heterodimer recognizes two classes of kappaB sites with two distinct modes. Embo Reports. 10: 152-9 |
| Fusco AJ, Savinova OV, Talwar R, et al. (2008) Stabilization of RelB requires multidomain interactions with p100/p52. The Journal of Biological Chemistry. 283: 12324-32 |
| Huang DB, Phelps CB, Fusco AJ, et al. (2005) Crystal structure of a free kappaB DNA: insights into DNA recognition by transcription factor NF-kappaB. Journal of Molecular Biology. 346: 147-60 |