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Holly A. Gratkowski, Ph.D.

Affiliations: 
2002 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Organic Chemistry, Chemical Biology, De Novo Protein Design
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"Holly Gratkowski"
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William F. DeGrado grad student 2002 Penn
 (Determinants of membrane protein structure probed by de novo design.)

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Lear JD, Stouffer AL, Gratkowski H, et al. (2004) Association of a model transmembrane peptide containing gly in a heptad sequence motif. Biophysical Journal. 87: 3421-9
Lear JD, Gratkowski H, Adamian L, et al. (2003) Position-dependence of stabilizing polar interactions of asparagine in transmembrane helical bundles. Biochemistry. 42: 6400-7
Li R, Mitra N, Gratkowski H, et al. (2003) Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations. Science (New York, N.Y.). 300: 795-8
DeGrado WF, Gratkowski H, Lear JD. (2003) How do helix-helix interactions help determine the folds of membrane proteins? Perspectives from the study of homo-oligomeric helical bundles. Protein Science : a Publication of the Protein Society. 12: 647-65
Gratkowski H, Dai QH, Wand AJ, et al. (2002) Cooperativity and specificity of association of a designed transmembrane peptide. Biophysical Journal. 83: 1613-9
Lear JD, Gratkowski H, DeGrado WF. (2001) De novo design, synthesis and characterization of membrane-active peptides Biochemical Society Transactions. 29: 559-564
Gratkowski H, Lear JD, DeGrado WF. (2001) Polar side chains drive the association of model transmembrane peptides Proceedings of the National Academy of Sciences of the United States of America. 98: 880-885
Choma C, Gratkowski H, Lear JD, et al. (2000) Asparagine-mediated self-association of a model transmembrane helix. Nature Structural Biology. 7: 161-6
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