Meredith E. Jackrel, Ph.D.
Affiliations: | 2010 | Yale University, New Haven, CT |
Area:
Protein Structure, Function, and DesignGoogle:
"Meredith Jackrel"Parents
Sign in to add mentor| Lynne Joy Regan | grad student | 2010 | Yale | |
| (Design of tetratricopeptide repeat proteins with novel binding specifications.) | ||||
| James Shorter | post-doc | University of Pennsylvania Medical School (Neurotree) | ||
Children
Sign in to add trainee| Braxton Bell | research assistant | Washington University | |
| Matthew Howard | research assistant | Washington University School of Medicine, Saint Louis | |
| Sheng Chen | grad student | Washington University | |
| Karlie Miller | grad student | Washington University | |
| Jeremy Ryan | grad student | Washington University | |
| Macy Sprunger | grad student | Washington University | |
| Maurie Balch | post-doc | 2018- | Washington University |
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Publications
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| Sprunger ML, Jackrel ME. (2024) The role of Matrin-3 in physiology and its dysregulation in disease. Biochemical Society Transactions |
| Lynch EM, Pittman S, Daw J, et al. (2024) Seeding competent TDP-43 persists in human patient and mouse muscle. Biorxiv : the Preprint Server For Biology |
| Chen S, Puri A, Bell B, et al. (2024) HTRA1 disaggregates α-synuclein amyloid fibrils and converts them into non-toxic and seeding incompetent species. Nature Communications. 15: 2436 |
| Chen S, Puri A, Bell B, et al. (2023) HtrA1 prevents and reverses α-synuclein aggregation, rendering it non-toxic and seeding incompetent. Research Square |
| Mack KL, Kim H, Barbieri EM, et al. (2023) Tuning Hsp104 specificity to selectively detoxify α-synuclein. Molecular Cell |
| Shrimali PC, Chen S, Das A, et al. (2023) Amyloidogenic Propensity of Self-Assembling Peptides and their Adjuvant Potential for use as DNA Vaccines. Acta Biomaterialia |
| Howard MK, Miller KR, Sohn BS, et al. (2023) Probing the drivers of biofilm protein amyloidogenesis and disrupting biofilms with engineered protein disaggregases. Mbio. e0058723 |
| Sprunger ML, Jackrel ME. (2022) Monitoring condensate dynamics in using fluorescence recovery after photobleaching. Star Protocols. 3: 101592 |
| Sprunger ML, Lee K, Sohn BS, et al. (2022) Molecular determinants and modifiers of Matrin-3 toxicity, condensate dynamics, and droplet morphology. Iscience. 25: 103900 |
| Sprunger ML, Jackrel ME. (2021) Prion-Like Proteins in Phase Separation and Their Link to Disease. Biomolecules. 11 |