Andrew J. Kale, Ph.D.

Affiliations: 
2012 Marine biology University of California, San Diego, La Jolla, CA 
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"Andrew Kale"

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Bradley S. Moore grad student 2012 UCSD
 (Proteasome inhibitor biosynthesis and self-resistance in the marine actinobacterium Salinispora tropica.)
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Publications

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Niewerth D, Jansen G, Riethoff LF, et al. (2014) Antileukemic activity and mechanism of drug resistance to the marine Salinispora tropica proteasome inhibitor salinosporamide A (Marizomib). Molecular Pharmacology. 86: 12-9
Kale AJ, Moore BS. (2012) Molecular mechanisms of acquired proteasome inhibitor resistance. Journal of Medicinal Chemistry. 55: 10317-27
Pereira AR, Kale AJ, Fenley AT, et al. (2012) The carmaphycins: new proteasome inhibitors exhibiting an α,β-epoxyketone warhead from a marine cyanobacterium. Chembiochem : a European Journal of Chemical Biology. 13: 810-7
Chen ZH, Wang BL, Kale AJ, et al. (2012) Coupling of sterically hindered aldehyde with fluorinated synthons: Stereoselective synthesis of fluorinated analogues of salinosporamide A Journal of Fluorine Chemistry. 136: 12-19
Kale AJ, McGlinchey RP, Lechner A, et al. (2011) Bacterial self-resistance to the natural proteasome inhibitor salinosporamide A. Acs Chemical Biology. 6: 1257-64
Kale AJ, McGlinchey RP, Moore BS. (2010) Characterization of 5-chloro-5-deoxy-D-ribose 1-dehydrogenase in chloroethylmalonyl coenzyme A biosynthesis: substrate and reaction profiling. The Journal of Biological Chemistry. 285: 33710-7
Nett M, Gulder TA, Kale AJ, et al. (2009) Function-oriented biosynthesis of beta-lactone proteasome inhibitors in Salinispora tropica. Journal of Medicinal Chemistry. 52: 6163-7
Eustáquio AS, McGlinchey RP, Liu Y, et al. (2009) Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine. Proceedings of the National Academy of Sciences of the United States of America. 106: 12295-300
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