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Zachary Q. Beck, Ph.D.

Affiliations: 
2001 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Biochemistry
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John H. Elder grad student 2001 Scripps Institute
 (HIV-1 and FIV protease substrate and inhibitor specificities.)

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Publications

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Ding Y, Seufert WH, Beck ZQ, et al. (2008) Analysis of the cryptophycin P450 epoxidase reveals substrate tolerance and cooperativity. Journal of the American Chemical Society. 130: 5492-8
Seufert W, Beck ZQ, Sherman DH. (2007) Enzymatic release and macrolactonization of cryptophycins from a safety-catch solid support. Angewandte Chemie (International Ed. in English). 46: 9298-300
Beck ZQ, Sherman DH. (2006) Development of an internally quenched fluorogenic substrate for kinetic analysis of thioesterases. Analytical Biochemistry. 349: 309-11
Beck ZQ, Aldrich CC, Magarvey NA, et al. (2005) Chemoenzymatic synthesis of cryptophycin/arenastatin natural products. Biochemistry. 44: 13457-66
Lin YC, Beck Z, Morris GM, et al. (2003) Structural basis for distinctions between substrate and inhibitor specificities for feline immunodeficiency virus and human immunodeficiency virus proteases. Journal of Virology. 77: 6589-600
Beck ZQ, Morris GM, Elder JH. (2002) Defining HIV-1 protease substrate selectivity. Current Drug Targets. Infectious Disorders. 2: 37-50
Beck ZQ, Lin YC, Elder JH. (2001) Molecular basis for the relative substrate specificity of human immunodeficiency virus type 1 and feline immunodeficiency virus proteases. Journal of Virology. 75: 9458-69
Beck ZQ, Hervio L, Dawson PE, et al. (2000) Identification of efficiently cleaved substrates for HIV-1 protease using a phage display library and use in inhibitor development. Virology. 274: 391-401
Lin YC, Beck Z, Lee T, et al. (2000) Alteration of substrate and inhibitor specificity of feline immunodeficiency virus protease Journal of Virology. 74: 4710-4720
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