Daniel H. Appella
Affiliations: | National Institutes of Health, Bethesda, MD | ||
| 2001-2004 | Chemistry | Northwestern University, Evanston, IL |
Area:
Organic ChemistryWebsite:
https://www.niddk.nih.gov/about-niddk/staff-directory/intramural/daniel-appella/pages/research-summary.aspxGoogle:
"Daniel Appella"Bio:
Parents
Sign in to add mentor| Samuel H. Gellman | grad student | 1998 | UW Madison | |
| (Synthesis and characterization of Helical β-peptides) | ||||
| Stephen L. Buchwald | post-doc | 1998-2001 | MIT | |
Children
Sign in to add trainee| Mark A. Witschi | grad student | 2006 | Northwestern |
| Ethan A. Englund | grad student | 2007 | Northwestern |
| Jonathan K. Pokorski | grad student | 2007 | Northwestern |
| Jaclyn A. Iera | grad student | 2008 | Northwestern |
| Ethan A. Englund | post-doc | National Insitutes of Health | |
| Hosahudya N. Gopi | post-doc | 2002-2003 | Northwestern |
| Matthew D. Hassink | post-doc | 2014 | National Institutes of Health |
| Andrew Dix | post-doc | 2011-2014 | National Insitutes of Health |
| Nathaniel I. Shank | post-doc | 2012-2015 | National Insitutes of Health |
| Kara G. Rosenker | post-doc | 2016 | NIH |
| Michael T. Scerba | post-doc | 2016 | NIH |
| Mrinmoy Saha | post-doc | 2015-2017 | NIH |
| Herman Nikolayevskiy | post-doc | 2017-2019 | NIH |
BETA: Related publications
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Publications
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| Robello M, Nikolayevskiy H, Scerba MT, et al. (2023) Prodrug Strategy Extends the Use of Anti-HIV Sulfanylbenzamides for Application . Acs Pharmacology & Translational Science. 7: 259-273 |
| Robello M, Zheng H, Saha M, et al. (2022) Alkyl-substituted N-methylaryl-N'-aryl-4-aminobenzamides: A new series of small molecule inhibitors for Wip1 phosphatase. European Journal of Medicinal Chemistry. 243: 114763 |
| Zheng H, Botos I, Clausse V, et al. (2021) Conformational constraints of cyclopentane peptide nucleic acids facilitate tunable binding to DNA. Nucleic Acids Research |
| Fouz MF, Appella DH. (2020) PNA Clamping in Nucleic Acid Amplification Protocols to Detect Single Nucleotide Mutations Related to Cancer. Molecules (Basel, Switzerland). 25 |
| Clausse V, Tao D, Debnath S, et al. (2019) Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. The Journal of Biological Chemistry |
| Nikolayevskiy H, Robello M, Scerba MT, et al. (2019) The structure-activity profile of mercaptobenzamides' anti-HIV activity suggests that thermodynamics of metabolism is more important than binding affinity to the target. European Journal of Medicinal Chemistry. 178: 818-837 |
| Miller Jenkins LM, Paine E, Deshmukh L, et al. (2019) Inhibition of HIV Maturation via Selective Unfolding and Crosslinking of Gag Polyprotein by a Mercaptobenzamide Acetylator. Journal of the American Chemical Society |
| Shank N, George Rosenker KM, Englund EA, et al. (2019) Synthesis and Application of KγT Peptide Nucleic Acids. Methods in Molecular Biology (Clifton, N.J.). 1973: 131-145 |
| Zheng H, Saha M, Appella DH. (2018) Synthesis of Fmoc-Protected ( S, S)- trans-Cyclopentane Diamine Monomers Enables the Preparation and Study of Conformationally Restricted Peptide Nucleic Acids. Organic Letters |
| Nikolayevskiy H, Scerba MT, Deschamps JR, et al. (2018) Reaction Kinetics Direct a Rational Synthesis of an HIV-1 Inactivator of Nucleocapsid Protein 7 and Provide Mechanistic Insight into Cellular Metabolism and Antiviral Activity. Chemistry (Weinheim An Der Bergstrasse, Germany) |