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Longqin Hu, Ph.D.

Affiliations: 
1999- Medicinal Chemistry Rutgers University, New Brunswick, New Brunswick, NJ, United States 
Area:
Medicinal Chemistry
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Parents

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Michael Doughty grad student 1988-1993 University of Kansas
Roberta F. Colman post-doc 1993-1996 University of Delaware

Children

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Yongying Jiang grad student 2005 Rutgers, New Brunswick
Xinghua Wu grad student 2008 Rutgers, New Brunswick
Herve Aloysius grad student 2014 Rutgers, New Brunswick
Lin Chen grad student 2014 Rutgers, New Brunswick
Daigo Inoyama grad student 2014 Rutgers, New Brunswick
Dhulfiqar Ali Abed grad student 2018 Rutgers, New Brunswick
Haifa Mohammed Albanyan grad student 2019 Rutgers, New Brunswick
Sumi Lee grad student 2019 Rutgers, New Brunswick
Ahmed R. Ali grad student 2021 Rutgers, New Brunswick
Jeffrey Yang grad student 2022 Rutgers, New Brunswick

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BETA: Related publications

Publications

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Hu L, Albanyan H, Yang J, et al. (2024) Structure-activity relationships and pharmacokinetic evaluation of L-cystine diamides as L-cystine crystallization inhibitors for cystinuria. Medicinal Chemistry Research : An International Journal For Rapid Communications On Design and Mechanisms of Action of Biologically Active Agents. 33: 1384-1407
Hu L, Albanyan H, Yang J, et al. (2024) 8-l-Cystinyl Bis(1,8-diazaspiro[4.5]decane) as an Orally Bioavailable l-Cystine Crystallization Inhibitor for Cystinuria. Acs Medicinal Chemistry Letters. 15: 1026-1031
Lee S, Ali AR, Abed DA, et al. (2023) Structural modification of C2-substituents on 1,4-bis(arylsulfonamido)benzene or naphthalene-N,N'-diacetic acid derivatives as potent inhibitors of the Keap1-Nrf2 protein-protein interaction. European Journal of Medicinal Chemistry. 265: 116104
Yang J, Albanyan H, Wang Y, et al. (2023) Development of convenient crystallization inhibition assays for structure-activity relationship studies in the discovery of crystallization inhibitors. Medicinal Chemistry Research : An International Journal For Rapid Communications On Design and Mechanisms of Action of Biologically Active Agents. 32: 1391-1399
Abed DA, Ali AR, Lee S, et al. (2023) Optimization of the C2 substituents on the 1,4-bis(arylsulfonamido)naphthalene-N,N'-diacetic acid scaffold for better inhibition of Keap1-Nrf2 protein-protein interaction. European Journal of Medicinal Chemistry. 252: 115302
Xie T, Zahid H, Ali AR, et al. (2023) Inhibitors of Keap1-Nrf2 protein-protein interaction reduce estrogen responsive gene expression and oxidative stress in estrogen receptor-positive breast cancer. Toxicology and Applied Pharmacology. 116375
Wang J, Lam D, Yang J, et al. (2022) Discovery of mobocertinib, a new irreversible tyrosine kinase inhibitor indicated for the treatment of non-small-cell lung cancer harboring EGFR exon 20 insertion mutations. Medicinal Chemistry Research : An International Journal For Rapid Communications On Design and Mechanisms of Action of Biologically Active Agents. 1-16
Lee S, Abed DA, Nguyen MU, et al. (2022) Structure-activity relationships of 1,4-bis(arylsulfonamido)-benzene or naphthalene-N,N'-diacetic acids with varying C2-substituents as inhibitors of Keap1-Nrf2 protein-protein interaction. European Journal of Medicinal Chemistry. 237: 114380
Abed DA, Lee S, Wen X, et al. (2021) Optimization of 1,4-bis(arylsulfonamido)naphthalene-N,N'-diacetic acids as inhibitors of Keap1-Nrf2 protein-protein interaction to suppress neuroinflammation. Bioorganic & Medicinal Chemistry. 44: 116300
Lee S, Abed DA, Beamer LJ, et al. (2020) Development of a Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay for the Inhibition of Keap1-Nrf2 Protein-Protein Interaction. Slas Discovery : Advancing Life Sciences R & D. 2472555220935816
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