Janine N. Bartholomew, Ph.D.
Affiliations: | 2009 | University of Pittsburgh, Pittsburgh, PA, United States |
Area:
Pharmacology, BiochemistryGoogle:
"Janine Bartholomew"Parents
Sign in to add mentor| Ferruccio Galbiatl | grad student | 2009 | University of Pittsburgh | |
| (Caveolin -1 mediated p53 activation in stress induced premature senescence and its antagonistic pleiotropic implications in cancer.) | ||||
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Publications
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| Volonte D, Zou H, Bartholomew JN, et al. (2015) Oxidative stress-induced inhibition of Sirt1 by caveolin-1 promotes p53-dependent premature senescence and stimulates the secretion of interleukin 6 (IL-6). The Journal of Biological Chemistry. 290: 4202-14 |
| Bartholomew JN, Galbiati F. (2010) Mapping of oxidative stress response elements of the caveolin-1 promoter. Methods in Molecular Biology (Clifton, N.J.). 594: 409-23 |
| Bartholomew JN, Volonte D, Galbiati F. (2009) Caveolin-1 regulates the antagonistic pleiotropic properties of cellular senescence through a novel Mdm2/p53-mediated pathway. Cancer Research. 69: 2878-86 |
| Bartholomew J, Reichart J, Mundy R, et al. (2008) GTP avoidance in Tetrahymena thermophila requires tyrosine kinase activity, intracellular calcium, NOS, and guanylyl cyclase. Purinergic Signalling. 4: 171-81 |
| Dasari A, Bartholomew JN, Volonte D, et al. (2006) Oxidative stress induces premature senescence by stimulating caveolin-1 gene transcription through p38 mitogen-activated protein kinase/Sp1-mediated activation of two GC-rich promoter elements. Cancer Research. 66: 10805-14 |