Sriram Krishnaswamy
Affiliations: | University of Pennsylvania, Philadelphia, PA, United States |
Area:
Blood coagulation, hemostasisGoogle:
"Sriram Krishnaswamy"Parents
Sign in to add mentor| John Kent Bryan | grad student | 1979-1984 | Syracuse |
| Kenneth G. Mann | post-doc | 1984-1987 | Univ. of Vermont College of Medicine |
Children
Sign in to add trainee| Kenneth A. Field | research assistant | University of Vermont | |
| Gregory D. Russell | research assistant | University of Vermont | |
| Randall K. Walker | grad student | University of Vermont | |
| Robert J. Baugh | post-doc | Emory | |
| Andreas G. Betz | post-doc | Emory | |
| Danilo S. Boskovic | post-doc | Penn | |
| Sai Kumar Buddai | post-doc | Penn | |
| Parvathi G. Kamath | post-doc | Penn | |
| Matthias Wilkens | post-doc | Penn |
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Publications
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| Kolyadko VN, Layzer JM, Perry K, et al. (2024) An RNA aptamer exploits exosite-dependent allostery to achieve specific inhibition of coagulation factor IXa. Proceedings of the National Academy of Sciences of the United States of America. 121: e2401136121 |
| Yu H, Kumar S, Frederiksen JW, et al. (2024) Aptameric hirudins as selective and reversible EXosite-ACTive site (EXACT) inhibitors. Nature Communications. 15: 3977 |
| Soule EE, Yu H, Olson L, et al. (2022) Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samples. Cell Chemical Biology |
| Basavaraj MG, Krishnaswamy S. (2020) Exosite binding drives substrate affinity for the activation of coagulation factor X by the intrinsic Xase complex. The Journal of Biological Chemistry |
| Cines DB, Zaitsev S, Rauova L, et al. (2020) FcRn augments induction of tissue factor activity by IgG-containing immune complexes. Blood |
| Bradford HN, Krishnaswamy S. (2018) Occlusion of anion binding exosite 2 in meizothrombin explains its impaired ability to activate factor V. The Journal of Biological Chemistry |
| Gunaratne R, Kumar S, Frederiksen JW, et al. (2018) Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass. Nature Biotechnology |
| Bunce M, Chintala M, Krishnaswamy S, et al. (2018) JNJ-64179375 Inhibits Exosite I-Mediated Thrombin Activity While Preserving Exosite II and Active Site Function in Vitro Blood. 132: 24-24 |
| Kamikubo Y, Mendolicchio GL, Zampolli A, et al. (2017) Selective factor VIII activation by the tissue factor-factor VIIa-factor Xa complex. Blood |
| Bradford HN, Krishnaswamy S. (2016) The Fragment 1 Region of Prothrombin Facilitates the Favored Binding of Fragment 12 to Zymogen and Enforces Zymogen-like Character in the Proteinase. The Journal of Biological Chemistry |