Nicholas C. Kallan, Ph.D.
Affiliations: | 2002 | University of Colorado, Boulder, Boulder, CO, United States |
Area:
Organic ChemistryGoogle:
"Nicholas Kallan"Parents
Sign in to add mentor| Randall Halcomb | grad student | 2002 | CU Boulder | |
| (Total synthesis of (+)-phomactin D and (+/-)-15- epi-phomactin D using an intramolecular B-alkyl Suzuki macrocyclization.) | ||||
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Publications
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| Hicken EJ, Marmsater FP, Munson MC, et al. (2014) Discovery of a Novel Class of Imidazo[1,2-a]Pyridines with Potent PDGFR Activity and Oral Bioavailability. Acs Medicinal Chemistry Letters. 5: 78-83 |
| Takahashi R, Ma S, Deese A, et al. (2014) Elucidating the mechanism of cytochrome P450-mediated pyrimidine ring conversion to pyrazole metabolites with the BACE1 inhibitor GNE-892 in rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 890-8 |
| Lane JW, Spencer KL, Shakya SR, et al. (2014) Synthesis of Akt inhibitor ipatasertib. part 1. Route scouting and early process development of a challenging cyclopentylpyrimidine intermediate Organic Process Research and Development. 18: 1641-1651 |
| Blake JF, Xu R, Bencsik JR, et al. (2012) Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors. Journal of Medicinal Chemistry. 55: 8110-27 |
| Fathi AT, Arowojolu O, Swinnen I, et al. (2012) A potential therapeutic target for FLT3-ITD AML: PIM1 kinase. Leukemia Research. 36: 224-31 |
| Xu R, Banka A, Blake JF, et al. (2011) Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA. Bioorganic & Medicinal Chemistry Letters. 21: 2335-40 |
| Kallan NC, Spencer KL, Blake JF, et al. (2011) Discovery and SAR of spirochromane Akt inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 2410-4 |
| Bencsik JR, Xiao D, Blake JF, et al. (2010) Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors. Bioorganic & Medicinal Chemistry Letters. 20: 7037-41 |
| Blake JF, Kallan NC, Xiao D, et al. (2010) Discovery of pyrrolopyrimidine inhibitors of Akt. Bioorganic & Medicinal Chemistry Letters. 20: 5607-12 |
| Kallan NC, Halcomb RL. (2000) Synthesis of the ring system of phomactin D using a Suzuki macrocyclization. Organic Letters. 2: 2687-90 |