Yane-Shih Wang, Ph. D.

Affiliations: 
2007-2012 Chemistry Texas A & M University, College Station, TX, United States 
 2012-2015 Molecular Biophysics and Biochemistry Yale University, New Haven, CT 
 2015-2025 Institute of Biological Chemistry Academia Sinica, Moni Vatopediou, Taipei City, Taiwan 
 2025- Chemistry National Taiwan Normal University, Taipei City, Taiwan 
Area:
Bioorganic Chemistry, Biocatalysis, Metalloenzyme
Google:
"https://shorturl.at/mrVbP"
Bio:

Yane-Shih is an assistant professor at the Department of Chemistry at National Taiwan Normal University, Taiwan. He received my Ph.D. in Chemistry (Wenshe Liu Lab) from Texas A&M University. He then completed postdoctoral training at Professor Dieter Söll's Lab at the Department of Molecular Biophysics and Biochemistry, Yale University, before joining the faculty at Academia Sinica and subsequently holding his current position at National Taiwan Normal University, Taiwan.

My research focuses on two key areas: developing a novel metalloenzyme for site-specific, rational modification of therapeutic proteins, and designing a genetic code expansion toolkit for in vivo encoding of D-amino acids and the creation of heterochiral therapeutic proteins.

Parents

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Sunney I. Chan research assistant 2003-2007 Academia Sinica, Taiwan
Wenshe Liu grad student 2007-2012 Texas A & M
 (Expanding Genetic Code for Protein Lysine and Phenylalanine Modifications)
Dieter Söll post-doc 2012-2015 Yale

Children

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Han-Kai Jiang research assistant 2015-2017 Academia Sinica
Han-Kai Jiang grad student 2017-2023 Academia Sinica
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Publications

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Tsou JC, Tsou CJ, Wang CH, et al. (2024) Site-Specific Histidine Aza-Michael Addition in Proteins Enabled by a Ferritin-Based Metalloenzyme. Journal of the American Chemical Society
Jiang HK, Weng JH, Wang YH, et al. (2023) Rational design of the genetic code expansion toolkit for encoding of D-amino acids. Frontiers in Genetics. 14: 1277489
Jiang HK, Ambrose NL, Chung CZ, et al. (2023) Split aminoacyl-tRNA synthetases for proximity-induced stop codon suppression. Proceedings of the National Academy of Sciences of the United States of America. 120: e2219758120
Guo LT, Amikura K, Jiang HK, et al. (2022) Ancestral Archaea Expanded the Genetic Code with Pyrrolysine. The Journal of Biological Chemistry. 102521
Wang YH, Jian ML, Chen PJ, et al. (2021) Ferritin Conjugates With Multiple Clickable Amino Acids Encoded by C-Terminal Engineered Pyrrolysyl-tRNA Synthetase. Frontiers in Chemistry. 9: 779976
Wang YS, Wu KP, Jiang HK, et al. (2020) Branched Ubiquitination: Detection Methods, Biological Functions and Chemical Synthesis. Molecules (Basel, Switzerland). 25
Jiang HK, Kurkute P, Li CL, et al. (2020) Revealing USP7 Deubiquitinase Substrate Specificity by Unbiased Synthesis of Ubiquitin Tagged SUMO2. Biochemistry
Tseng HW, Baumann T, Sun H, et al. (2020) Expanding the Scope of Orthogonal Translation with Pyrrolysyl-tRNA Synthetases Dedicated to Aromatic Amino Acids. Molecules (Basel, Switzerland). 25
Jiang HK, Wang YH, Weng JH, et al. (2020) Probing the active site of deubiquitinase USP30 with non-canonical tryptophan analogues. Biochemistry
Jiang HK, Lee MN, Tsou JC, et al. (2020) Linker and N-Terminal Domain Engineering of Pyrrolysyl-tRNA Synthetase for Substrate Range Shifting and Activity Enhancement. Frontiers in Bioengineering and Biotechnology. 8: 235
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