Brad Backes
Affiliations: | 1998 | University of California, San Francisco, San Francisco, CA |
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"Brad Backes"
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| Feldman HC, Tong M, Wang L, et al. (2016) Structural and Functional Analysis of the Allosteric Inhibition of IRE1α with ATP-Competitive Ligands. Acs Chemical Biology |
| Ghosh R, Wang L, Wang ES, et al. (2014) Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress. Cell. 158: 534-48 |
| Wang L, Perera BG, Hari SB, et al. (2012) Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors. Nature Chemical Biology. 8: 982-9 |
| Maly DJ, Leonetti F, Backes BJ, et al. (2002) Expedient solid-phase synthesis of fluorogenic protease substrates using the 7-amino-4-carbamoylmethylcoumarin (ACC) fluorophore. The Journal of Organic Chemistry. 67: 910-5 |
| Harris JL, Niles A, Burdick K, et al. (2001) Definition of the extended substrate specificity determinants for beta-tryptases I and II. The Journal of Biological Chemistry. 276: 34941-7 |
| Harris JL, Backes BJ, Leonetti F, et al. (2000) Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries. Proceedings of the National Academy of Sciences of the United States of America. 97: 7754-9 |
| Backes BJ, Harris JL, Leonetti F, et al. (2000) Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin. Nature Biotechnology. 18: 187-93 |
| Backes BJ, Dragoli DR, Ellman JA. (1999) Chiral N-Acyl-tert-butanesulfinamides: The "Safety-Catch" Principle Applied to Diastereoselective Enolate Alkylations. The Journal of Organic Chemistry. 64: 5472-5478 |
| Backes BJ, Dragoli DR, Ellman JA. (1999) Chiral N-acyl-tert-butanesulfinamides: The 'safety-catch' principle applied to diastereoselective enolate alkylations Journal of Organic Chemistry. 64: 5472-5478 |
| Backes BJ, Ellman JA. (1999) An alkanesulfonamide 'safety-catch' linker for solid-phase synthesis Journal of Organic Chemistry. 64: 2322-2330 |