Jason C. Wong
Affiliations: | 2004 | Harvard University, Cambridge, MA, United States |
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"Jason Wong"Parents
Sign in to add mentor| Stuart L. Schreiber | grad student | 2004 | Harvard | |
| (Discovery of small molecule probes for chemical genetics using biased and unbiased diversity-oriented organic synthesis.) | ||||
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Publications
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| Lin X, Chen W, Qiu Z, et al. (2015) Design and synthesis of orally bioavailable aminopyrrolidinone histone deacetylase 6 inhibitors. Journal of Medicinal Chemistry. 58: 2809-20 |
| Tang G, Wong JC, Zhang W, et al. (2014) Identification of a novel aminotetralin class of HDAC6 and HDAC8 selective inhibitors. Journal of Medicinal Chemistry. 57: 8026-34 |
| Wong JC, Guo L, Peng Z, et al. (2011) Application of p21 and klf2 reporter gene assays to identify selective histone deacetylase inhibitors for cancer therapy. Bioorganic & Medicinal Chemistry Letters. 21: 110-6 |
| Cheng Q, Balzer E, Miller SM, et al. (2006) EFFECT OF HISTONE DEACETYLASE INHIBITORS ON TUBULIN ACETYLATION AND DEVELOPMENT IN VOLVOX CARTERI (VOLVOCALES)1 Journal of Phycology. 42: 417-422 |
| Hideshima T, Bradner JE, Wong J, et al. (2005) Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma. Proceedings of the National Academy of Sciences of the United States of America. 102: 8567-72 |
| Marcus AI, Zhou J, O'Brate A, et al. (2005) The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase. Cancer Research. 65: 3883-93 |
| Haggarty SJ, Clemons PA, Wong JC, et al. (2004) Mapping chemical space using molecular descriptors and chemical genetics: deacetylase inhibitors. Combinatorial Chemistry & High Throughput Screening. 7: 669-76 |
| Wong JC, Sternson SM, Louca JB, et al. (2004) Modular synthesis and preliminary biological evaluation of stereochemically diverse 1,3-dioxanes. Chemistry & Biology. 11: 1279-91 |
| Koeller KM, Haggarty SJ, Perkins BD, et al. (2003) Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histone and tubulin acetylation. Chemistry & Biology. 10: 397-410 |
| Haggarty SJ, Koeller KM, Wong JC, et al. (2003) Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays. Chemistry & Biology. 10: 383-96 |