Adam Rolt
Affiliations: | University of Oxford, Oxford, United Kingdom |
Area:
Drug discoveryGoogle:
"Adam Rolt"Parents
Sign in to add mentor| T. Jake Liang | grad student | (Neurotree) | |
| Andrew Stachulski | grad student | Liverpool |
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Publications
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| Rolt A, Talley DC, Park SB, et al. (2021) Discovery and Optimization of a 4-Aminopiperidine Scaffold for Inhibition of Hepatitis C Virus Assembly. Journal of Medicinal Chemistry |
| Podszun MC, Alawad AS, Lingala S, et al. (2020) Vitamin E treatment in NAFLD patients demonstrates that oxidative stress drives steatosis through upregulation of de-novo lipogenesis. Redox Biology. 37: 101710 |
| Ma CD, Imamura M, Talley DC, et al. (2020) Fluoxazolevir inhibits hepatitis C virus infection in humanized chimeric mice by blocking viral membrane fusion. Nature Microbiology |
| Hu Z, Rolt A, Hu X, et al. (2020) Chlorcyclizine Inhibits Viral Fusion of Hepatitis C Virus Entry by Directly Targeting HCV Envelope Glycoprotein 1. Cell Chemical Biology |
| Rolt A, O'Neill PM, Liang TJ, et al. (2019) Synthesis of MeBmt and related derivatives syn-selective ATH-DKR. Rsc Advances. 9: 40336-40339 |
| Rolt A, Le D, Hu Z, et al. (2018) Preclinical Pharmacological Development of Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection. The Journal of Infectious Diseases |
| Podszun MC, Rolt A, Garaffo M, et al. (2017) Vitamin E (RRR-α-tocopherol) decreases hepatic de novo lipogenesis Free Radical Biology and Medicine. 112: 30-31 |
| He S, Xiao J, Dulcey AE, et al. (2015) Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection. Journal of Medicinal Chemistry |