Gangadhar G. Durgam, Ph.D.

Affiliations: 
2005 University of Tennessee Health Science Center, Memphis, TN, United States 
Area:
Pharmaceutical Chemistry
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"Gangadhar Durgam"

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Duane Douglas Miller grad student 2005 UTHSC
 (Design, synthesis and evaluation of novel ligands for lysophosphatidic acid receptors.)
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Publications

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Khandoga AL, Fujiwara Y, Goyal P, et al. (2008) Lysophosphatidic acid-induced platelet shape change revealed through LPA(1-5) receptor-selective probes and albumin. Platelets. 19: 415-27
Deng W, Shuyu E, Tsukahara R, et al. (2007) The lysophosphatidic acid type 2 receptor is required for protection against radiation-induced intestinal injury. Gastroenterology. 132: 1834-51
Durgam GG, Tsukahara R, Makarova N, et al. (2006) Synthesis and pharmacological evaluation of second-generation phosphatidic acid derivatives as lysophosphatidic acid receptor ligands. Bioorganic & Medicinal Chemistry Letters. 16: 633-40
Goyal P, Durgam G, Wilke N, et al. (2006) We-P11:210 Evaluation of novel phosphatidic acid derivatives as antagonists of platelet activation induced by the plaque lipid lysophosphatidic acid Atherosclerosis Supplements. 7: 392
Durgam GG, Virag T, Walker MD, et al. (2005) Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin. Journal of Medicinal Chemistry. 48: 4919-30
Gududuru V, Hurh E, Durgam GG, et al. (2004) Synthesis and biological evaluation of novel cytotoxic phospholipids for prostate cancer. Bioorganic & Medicinal Chemistry Letters. 14: 4919-23
Virag T, Elrod DB, Liliom K, et al. (2003) Fatty alcohol phosphates are subtype-selective agonists and antagonists of lysophosphatidic acid receptors. Molecular Pharmacology. 63: 1032-42
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