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Schönfeld J, Brunst S, Ciomirtan L, et al. (2025) Structure-Based Design of PROTACS for the Degradation of Soluble Epoxide Hydrolase. Journal of Medicinal Chemistry |
Dreizler JK, Meyners C, Sugiarto WO, et al. (2025) Broad Target Screening Reveals Abundance of FKBP12-Based Molecular Glues in Focused Libraries. Journal of Medicinal Chemistry. 68: 9525-9536 |
Mandel S, Hanke T, Mathea S, et al. (2025) Repurposing of the RIPK1-Selective Benzo[1,4]oxazepin-4-one Scaffold for the Development of a Type III LIMK1/2 Inhibitor. Acs Chemical Biology |
Schwalm MP, Menge A, Elson L, et al. (2025) Functional Characterization of Pathway Inhibitors for the Ubiquitin-Proteasome System (UPS) as Tool Compounds for CRBN and VHL-Mediated Targeted Protein Degradation. Acs Chemical Biology. 20: 94-104 |
Virtanen A, Kettunen V, Musta K, et al. (2024) Molecular basis of JAK kinase regulation guiding therapeutic approaches: Evaluating the JAK3 pseudokinase domain as a drug target. Advances in Biological Regulation. 95: 101072 |
Haag A, Němec V, Janovská P, et al. (2024) Development and Discovery of a Selective Degrader of Casein Kinases 1 δ/ε. Journal of Medicinal Chemistry |
Wang G, Seidler NJ, Röhm S, et al. (2024) Probing the Protein Kinases' Cysteinome by Covalent Fragments. Angewandte Chemie (International Ed. in English). e202419736 |
Münick P, Zielinski J, Strubel A, et al. (2024) DARPins as a novel tool to detect and degrade p73. Cell Death & Disease. 15: 909 |
Sander P, Schwalm MP, Krämer A, et al. (2024) Design, Synthesis, and Biochemical Evaluation of Novel MLK3 Inhibitors: A Target Hopping Example. Journal of Medicinal Chemistry |
Raig ND, Surridge KJ, Sanz-Murillo M, et al. (2024) Type-II kinase inhibitors that target Parkinson's Disease-associated LRRK2. Biorxiv : the Preprint Server For Biology |