Lisa-Maria Needham

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2014-2018 Chemistry University of Cambridge, Cambridge, England, United Kingdom 
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"Lisa-Maria Needham"
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Saavedra Salazar CA, Sole-Barber D, Wan S, et al. (2025) The Origin of Single-Molecule Sensitivity in Label-Free Solution-Phase Optical Microcavity Detection. Acs Nano. 19: 6342-6356
Bruggeman E, Zhang O, Needham LM, et al. (2024) POLCAM: instant molecular orientation microscopy for the life sciences. Nature Methods
Needham LM, Saavedra C, Rasch JK, et al. (2024) Label-free detection and profiling of individual solution-phase molecules. Nature. 629: 1062-1068
Needham LM, Saavedra C, Rasch JK, et al. (2023) Label-free observation of individual solution phase molecules. Biorxiv : the Preprint Server For Biology
Gorka F, Daly S, Pearson CM, et al. (2021) A Comparative Study of High-Contrast Fluorescence Lifetime Probes for Imaging Amyloid in Tissue. The Journal of Physical Chemistry. B
Vilalta A, Zhou Y, Sevalle J, et al. (2021) Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation. The Journal of Biological Chemistry. 100631
Samaan GN, Wyllie MK, Cizmic JM, et al. (2020) Single-molecule fluorescence detection of a tricyclic nucleoside analogue. Chemical Science. 12: 2623-2628
Needham LM, Weber J, Varela JA, et al. (2020) ThX - a next-generation probe for the early detection of amyloid aggregates. Chemical Science. 11: 4578-4583
Spark A, Kitching A, Esteban-Ferrer D, et al. (2020) vLUME: 3D virtual reality for single-molecule localization microscopy. Nature Methods
Needham LM, Weber J, Pearson CM, et al. (2020) A Comparative Photophysical Study of Structural Modifications of Thioflavin T-Inspired Fluorophores. The Journal of Physical Chemistry Letters
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