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Alexander S. Freed, Ph.D.

Affiliations: 
2010 Rensselaer Polytechnic Institute, Troy, NY, United States 
Area:
Chemical Engineering
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"Alexander Freed"
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Steven M. Cramer grad student 2010 RPI
 (Multiscale Modeling of Chromatographic Systems: Insights into Protein Selectivity, Ligand Design and Methods Development.)

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Publications

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Holstein MA, Chung WK, Parimal S, et al. (2012) Probing multimodal ligand binding regions on ubiquitin using nuclear magnetic resonance, chromatography, and molecular dynamics simulations. Journal of Chromatography. A. 1229: 113-20
Freed AS, Garde S, Cramer SM. (2011) Molecular simulations of multimodal ligand-protein binding: elucidation of binding sites and correlation with experiments. The Journal of Physical Chemistry. B. 115: 13320-7
Freed AS, Cramer SM. (2011) Protein-surface interaction maps for ion-exchange chromatography. Langmuir : the Acs Journal of Surfaces and Colloids. 27: 3561-8
Chung WK, Freed AS, Holstein MA, et al. (2010) Evaluation of protein adsorption and preferred binding regions in multimodal chromatography using NMR Proceedings of the National Academy of Sciences of the United States of America. 107: 16811-16816
Evans ST, Morrison CJ, Freed A, et al. (2010) The effect of feed composition on the behavior of chemically selective displacement systems. Journal of Chromatography. A. 1217: 1249-54
Chung WK, Hou Y, Holstein M, et al. (2010) Investigation of protein binding affinity in multimodal chromatographic systems using a homologous protein library. Journal of Chromatography. A. 1217: 191-8
Chung WK, Evans ST, Freed AS, et al. (2010) Utilization of lysozyme charge ladders to examine the effects of protein surface charge distribution on binding affinity in ion exchange systems. Langmuir : the Acs Journal of Surfaces and Colloids. 26: 759-68
Evans ST, Freed A, Cramer SM. (2009) Displacer concentration effects in displacement chromatography. Implications for trace solute detection. Journal of Chromatography. A. 1216: 79-85
Chung WK, Hou Y, Freed A, et al. (2009) Investigation of protein binding affinity and preferred orientations in ion exchange systems using a homologous protein library. Biotechnology and Bioengineering. 102: 869-81
Yang T, Sundling MC, Freed AS, et al. (2007) Prediction of pH-dependent chromatographic behavior in ion-exchange systems. Analytical Chemistry. 79: 8927-39
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