Kevin J. Duffy
Affiliations: | GlaxoSmithKline, Collegeville, PA, United States |
Area:
Drug DiscoveryGoogle:
"Kevin Duffy"
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Publications
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| Ariazi JL, Duffy KJ, Adams DF, et al. (2017) Discovery and Preclinical Characterization of GSK1278863 (daprodustat), A Small Molecule Hypoxia Inducible Factor (HIF)-Prolyl Hydroxylase Inhibitor for Anemia. The Journal of Pharmacology and Experimental Therapeutics |
| Billiard J, Annan R, Ariazi J, et al. (2013) Abstract 5418: Rapid LDH5 inhibition reverses malignant metabolic phenotype and impairs survival of hepatocellular carcinoma cells . Cancer Research. 73: 5418-5418 |
| Qian X, McDonald A, Zhou HJ, et al. (2010) Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295. Acs Medicinal Chemistry Letters. 1: 30-4 |
| Shaw AN, Tedesco R, Bambal R, et al. (2009) Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase. Bioorganic & Medicinal Chemistry Letters. 19: 4350-3 |
| Tedesco R, Chai D, Darcy MG, et al. (2009) Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzothiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 4354-8 |
| Erickson-Miller CL, Delorme E, Tian SS, et al. (2009) Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist. Stem Cells (Dayton, Ohio). 27: 424-30 |
| Parrish CA, Adams ND, Auger KR, et al. (2007) Novel ATP-competitive kinesin spindle protein inhibitors. Journal of Medicinal Chemistry. 50: 4939-52 |
| Erickson-Miller CL, Creasy C, Chadderton A, et al. (2007) GSK626616: A DYRK3 Inhibitor as a Potential New Therapy for the Treatment of Anemia. Blood. 110: 510-510 |
| Tedesco R, Shaw AN, Bambal R, et al. (2006) 3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase. Journal of Medicinal Chemistry. 49: 971-83 |
| Erickson-Miller CL, DeLorme E, Tian SS, et al. (2005) Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist. Experimental Hematology. 33: 85-93 |