Mariana Figuera-Losada
Affiliations: | 2013- | Albert Einstein College of Medicine, New York, New York, United States |
Area:
biochemistryGoogle:
"Mariana Figuera-Losada"Parents
Sign in to add mentor| Francis J. Castellino | grad student | 2008 | Notre Dame | |
| (Human plasminogen, conformational transitions and activation.) | ||||
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Publications
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| Figuera-Losada M, Thomas AG, Stathis M, et al. (2017) Development of a primary microglia screening assay and its use to characterize inhibition of system xc(-) by erastin and its analogs. Biochemistry and Biophysics Reports. 9: 266-272 |
| Figuera-Losada M, Stathis M, Dorskind JM, et al. (2015) Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties. Plos One. 10: e0124481 |
| Figuera-Losada M, Rojas C, Slusher BS. (2014) Inhibition of microglia activation as a phenotypic assay in early drug discovery. Journal of Biomolecular Screening. 19: 17-31 |
| Feng Y, Chambers JW, Iqbal S, et al. (2013) A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases. Acs Chemical Biology. 8: 1747-54 |
| Laughlin JD, Nwachukwu JC, Figuera-Losada M, et al. (2012) Structural mechanisms of allostery and autoinhibition in JNK family kinases. Structure (London, England : 1993). 20: 2174-84 |
| Figuera-Losada M, LoGrasso PV. (2012) Enzyme kinetics and interaction studies for human JNK1β1 and substrates activating transcription factor 2 (ATF2) and c-Jun N-terminal kinase (c-Jun). The Journal of Biological Chemistry. 287: 13291-302 |
| Chambers JW, Cherry L, Laughlin JD, et al. (2011) Selective inhibition of mitochondrial JNK signaling achieved using peptide mimicry of the Sab kinase interacting motif-1 (KIM1). Acs Chemical Biology. 6: 808-18 |
| Figuera-Losada M, Ranson M, Sanderson-Smith ML, et al. (2010) Effects on human plasminogen conformation and activation rate caused by interaction with VEK-30, a peptide derived from the group A streptococcal M-like protein (PAM). Biochimica Et Biophysica Acta. 1804: 1342-9 |
| Kamenecka T, Jiang R, Song X, et al. (2010) Synthesis, biological evaluation, X-ray structure, and pharmacokinetics of aminopyrimidine c-jun-N-terminal kinase (JNK) inhibitors. Journal of Medicinal Chemistry. 53: 419-31 |
| Fu Q, Figuera-Losada M, Ploplis VA, et al. (2008) The lack of binding of VEK-30, an internal peptide from the group A streptococcal M-like protein, PAM, to murine plasminogen is due to two amino acid replacements in the plasminogen kringle-2 domain. The Journal of Biological Chemistry. 283: 1580-7 |