Parents
Sign in to add mentor| John Louis Wood | grad student | 2001 | Yale | |
| (Progress toward a total synthesis of the welwitindolinone alkaloids.) | ||||
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| Cheng Y, Brown J, Judd TC, et al. (2015) An Orally Available BACE1 Inhibitor That Affords Robust CNS Aβ Reduction without Cardiovascular Liabilities. Acs Medicinal Chemistry Letters. 6: 210-5 |
| Chen JJ, Liu Q, Yuan C, et al. (2015) Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer's disease. Bioorganic & Medicinal Chemistry Letters. 25: 767-74 |
| Epstein O, Bryan MC, Cheng AC, et al. (2014) Lead optimization and modulation of hERG activity in a series of aminooxazoline xanthene β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors. Journal of Medicinal Chemistry. 57: 9796-810 |
| Dineen TA, Chen K, Cheng AC, et al. (2014) Inhibitors of β-site amyloid precursor protein cleaving enzyme (BACE1): identification of (S)-7-(2-fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine (AMG-8718). Journal of Medicinal Chemistry. 57: 9811-31 |
| Navarro Villalobos M, Wood JL, Jeong S, et al. (2009) Total syntheses of (+)- and (-)-syringolides 3 and of (+)- and (-)-syributins 1, 2 and 3 Tetrahedron. 65: 8091-8098 |
| Harmange JC, Weiss MM, Germain J, et al. (2008) Naphthamides as novel and potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: design, synthesis, and evaluation. Journal of Medicinal Chemistry. 51: 1649-67 |
| Reisman SE, Ready JM, Weiss MM, et al. (2008) Evolution of a synthetic strategy: total synthesis of (+/-)-welwitindolinone A isonitrile. Journal of the American Chemical Society. 130: 2087-100 |
| Ready JM, Reisman SE, Hirata M, et al. (2004) A mild and efficient synthesis of oxindoles: progress towards the synthesis of welwitindolinone A isonitrile. Angewandte Chemie (International Ed. in English). 43: 1270-2 |
| Dounay AB, Hatanaka K, Kodanko JJ, et al. (2003) Catalytic asymmetric synthesis of quaternary carbons bearing two aryl substituents. Enantioselective synthesis of 3-alkyl-3-aryl oxindoles by catalytic asymmetric intramolecular heck reactions. Journal of the American Chemical Society. 125: 6261-71 |
| Wood JL, Holubec AA, Stoltz BM, et al. (1999) Application of reactive enols in synthesis: A versatile, efficient, and stereoselective construction of the welwitindolinone carbon skeleton [11] Journal of the American Chemical Society. 121: 6326-6327 |