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John S. Schneekloth, Ph.D. - Publications

Affiliations: 
Yale University, New Haven, CT 
Area:
organic synthesis, pharmacology, molecular biology
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47 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Prestwood PR, Yang M, Lewis GV, Balaratnam S, Yazdani K, Schneekloth JS. Competitive Microarray Screening Reveals Functional Ligands for the DHX15 RNA G-Quadruplex. Acs Medicinal Chemistry Letters. 15: 814-821. PMID 38894923 DOI: 10.1021/acsmedchemlett.3c00574  0.318
2022 Patel N, Abulwerdi F, Fatehi F, Manfield IW, Le Grice S, Schneekloth JS, Twarock R, Stockley PG. Dysregulation of Hepatitis B Virus Nucleocapsid Assembly in vitro by RNA-binding Small Ligands. Journal of Molecular Biology. 434: 167557. PMID 35341740 DOI: 10.1016/j.jmb.2022.167557  0.3
2021 Swain M, Ageeli AA, Kasprzak WK, Li M, Miller JT, Sztuba-Solinska J, Schneekloth JS, Koirala D, Piccirili J, Fraboni AJ, Murelli RP, Wlodawer A, Shapiro BA, Baird N, Le Grice SFJ. Dynamic bulge nucleotides in the KSHV PAN ENE triple helix provide a unique binding platform for small molecule ligands. Nucleic Acids Research. PMID 34871450 DOI: 10.1093/nar/gkab1170  0.311
2020 Tran B, Pichling P, Tenney L, Connelly CM, Moon MH, Ferré-D'Amaré AR, Schneekloth JS, Jones CP. Parallel Discovery Strategies Provide a Basis for Riboswitch Ligand Design. Cell Chemical Biology. PMID 32795418 DOI: 10.1016/J.Chembiol.2020.07.021  0.372
2020 Wu G, Tillo D, Ray S, Chang TC, Schneekloth JS, Vinson C, Yang D. Custom G4 Microarrays Reveal Selective G-Quadruplex Recognition of Small Molecule BMVC: A Large-Scale Assessment of Ligand Binding Selectivity. Molecules (Basel, Switzerland). 25. PMID 32751510 DOI: 10.3390/Molecules25153465  0.335
2020 Ray S, Tillo D, Boer RE, Assad N, Barshai M, Wu G, Orenstein Y, Yang D, Schneekloth JS, Vinson C. Custom DNA microarrays reveal diverse binding preferences of proteins and small molecules to thousands of G-quadruplexes. Acs Chemical Biology. PMID 32216326 DOI: 10.1021/Acschembio.9B00934  0.365
2020 Boer RE, Torrey ZR, Schneekloth JS. Chemical Modulation of Pre-mRNA Splicing in Mammalian Systems. Acs Chemical Biology. PMID 32191432 DOI: 10.1021/Acschembio.0C00001  0.343
2020 Schmidt K, Weidmann CA, Hilimire TA, Yee E, Hatfield BM, Schneekloth JS, Weeks KM, Novina CD. Targeting the Oncogenic Long Non-coding RNA SLNCR1 by Blocking Its Sequence-Specific Binding to the Androgen Receptor. Cell Reports. 30: 541-554.e5. PMID 31940495 DOI: 10.1016/J.Celrep.2019.12.011  0.341
2020 Neckles C, Boer RE, Aboreden N, Cross AM, Walker RL, Kim B, Kim S, Schneekloth JS, Caplen NJ. Abstract B25: HNRNPH1-dependent splicing of the fusion oncogene EWS-FLI1 reveals a targetable RNA G-quadruplex interaction Cancer Research. 80. DOI: 10.1158/1538-7445.Pedca19-B25  0.388
2019 Neckles C, Boer RE, Aboreden N, Cross AM, Walker RL, Kim BH, Kim S, Schneekloth JS, Caplen NJ. HNRNPH1-dependent splicing of a fusion oncogene reveals a targetable RNA G-quadruplex interaction. Rna (New York, N.Y.). PMID 31511320 DOI: 10.1261/Rna.072454.119  0.352
2019 Calabrese DR, Connelly CM, Schneekloth JS. Ligand-observed NMR techniques to probe RNA-small molecule interactions. Methods in Enzymology. 623: 131-149. PMID 31239044 DOI: 10.1016/Bs.Mie.2019.05.030  0.362
2019 Hewitt WM, Calabrese DR, Schneekloth JS. Evidence for ligandable sites in structured RNA throughout the Protein Data Bank. Bioorganic & Medicinal Chemistry. PMID 30982658 DOI: 10.1016/J.Bmc.2019.04.010  0.404
2019 Connelly CM, Numata T, Boer RE, Moon MH, Sinniah RS, Barchi JJ, Ferré-D'Amaré AR, Schneekloth JS. Synthetic ligands for PreQ riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure. Nature Communications. 10: 1501. PMID 30940810 DOI: 10.1038/S41467-019-09493-3  0.403
2019 Abulwerdi FA, Xu W, Ageeli AA, Yonkunas MJ, Arun G, Nam H, Schneekloth JS, Dayie TK, Spector D, Baird N, Le Grice SFJ. Selective small molecule targeting of a triple helix encoded by the long non-coding RNA, MALAT1. Acs Chemical Biology. PMID 30620551 DOI: 10.1021/Acschembio.8B00807  0.365
2019 Gunther EC, Smith LM, Kostylev MA, Cox TO, Kaufman AC, Lee S, Folta-Stogniew E, Maynard GD, Um JW, Stagi M, Heiss JK, Stoner A, Noble GP, Takahashi H, Haas LT, ... Schneekloth JS, et al. Rescue of Transgenic Alzheimer's Pathophysiology by Polymeric Cellular Prion Protein Antagonists. Cell Reports. 26: 145-158.e8. PMID 30605671 DOI: 10.1016/J.Celrep.2018.12.021  0.326
2019 Neckles C, Boer R, Aboreden N, Walker RL, Kim B, Kim S, Schneekloth JS, Caplen NJ. Abstract 4494: HNRNPH1-dependent splicing of a fusion oncogene reveals a targetable RNA G-quadruplex interaction Cancer Research. 79: 4494-4494. DOI: 10.1158/1538-7445.Am2019-4494  0.372
2019 Tran BN, Jones CP, Connelly C, Schneekloth JS, Ferre-D'Amare AR. Screening for Small Molecule Binders to the ZTP Riboswitch, a Bacterial Regulator of Folate Metabolism Biophysical Journal. 116: 354a. DOI: 10.1016/J.Bpj.2018.11.1925  0.337
2018 Journey SN, Alden SL, Hewitt WM, Peach ML, Nicklaus MC, Schneekloth JS. Probing the -1 i-motif with small molecules. Medchemcomm. 9: 2000-2007. PMID 30647878 DOI: 10.1039/C8Md00311D  0.391
2018 Boer RE, Schneekloth JS. Targeting Mammalian Translational Inhibition with Tetracyclines. Cell Chemical Biology. 25: 1437-1438. PMID 30576658 DOI: 10.1016/J.Chembiol.2018.12.006  0.309
2018 Calabrese DR, Chen X, Leon EC, Gaikwad SM, Phyo Z, Hewitt WM, Alden S, Hilimire TA, He F, Michalowski AM, Simmons JK, Saunders LB, Zhang S, Connors D, Walters KJ, ... ... Schneekloth JS, et al. Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex. Nature Communications. 9: 4229. PMID 30315240 DOI: 10.1038/S41467-018-06315-W  0.323
2018 Yan P, Ritt DA, Zlotkowski K, Bokesch HR, Reinhold WC, Schneekloth JS, Morrison DK, Gustafson KR. Macrophilones from the Marine Hydroid Macrorhynchia philippina Can Inhibit ERK Cascade Signaling. Journal of Natural Products. PMID 29979591 DOI: 10.1021/Acs.Jnatprod.8B00343  0.369
2018 Calabrese DR, Zlotkowski K, Alden S, Hewitt WM, Connelly CM, Wilson RM, Gaikwad S, Chen L, Guha R, Thomas CJ, Mock BA, Schneekloth JS. Characterization of clinically used oral antiseptics as quadruplex-binding ligands. Nucleic Acids Research. PMID 29481610 DOI: 10.1093/Nar/Gky084  0.37
2018 Moon MH, Hilimire T, Sanders AM, Schneekloth JS. Measuring RNA-Ligand Interactions with Microscale Thermophoresis. Biochemistry. PMID 29327580 DOI: 10.1021/Acs.Biochem.7B01141  0.349
2017 Zlotkowski K, Hewitt WM, Yan P, Bokesch HR, Peach ML, Nicklaus MC, O'Keefe BR, McMahon JB, Gustafson KR, Schneekloth JS. Macrophilone A: Structure Elucidation, Total Synthesis, and Functional Evaluation of a Biologically Active Iminoquinone from the Marine Hydroid Macrorhynchia philippina. Organic Letters. PMID 28345939 DOI: 10.1021/Acs.Orglett.7B00496  0.319
2017 Gaikwad SM, Calabrese DR, Leon EC, Simmons JK, Zhang S, Michalowski A, Gorjifard S, Phyo Z, Connors D, Schneekloth JS, Mock BA. Abstract 194: Effective targeting of MYC expression with a novel nucleic acid binding (G4-quadruplex) small molecule coupled with HDAC inhibition synergizes to limit myeloma growth Cancer Research. 77: 194-194. DOI: 10.1158/1538-7445.Am2017-194  0.359
2016 Abulwerdi FA, Shortridge MD, Sztuba-Solinska J, Wilson R, Le Grice SF, Varani G, Schneekloth JS. Development of Small Molecules with a Noncanonical Binding Mode to HIV-1 Trans Activation Response (TAR) RNA. Journal of Medicinal Chemistry. 59: 11148-11160. PMID 28002966 DOI: 10.1021/Acs.Jmedchem.6B01450  0.357
2016 Connelly CM, Boer RE, Moon MH, Gareiss P, Schneekloth JS. Discovery of Inhibitors of MicroRNA-21 Processing Using Small Molecule Microarrays. Acs Chemical Biology. PMID 27959491 DOI: 10.1021/Acschembio.6B00945  0.381
2016 Connelly CM, Moon MH, Schneekloth JS. The Emerging Role of RNA as a Therapeutic Target for Small Molecules. Cell Chemical Biology. PMID 27593111 DOI: 10.1016/J.Chembiol.2016.05.021  0.375
2016 Abulwerdi FA, Schneekloth JS. Microarray-based technologies for the discovery of selective, RNA-binding molecules. Methods (San Diego, Calif.). PMID 27109057 DOI: 10.1016/J.Ymeth.2016.04.022  0.384
2016 Hewitt WM, Lountos GT, Zlotkowski K, Dahlhauser SD, Saunders LB, Needle D, Tropea JE, Zhan C, Wei G, Ma B, Nussinov R, Waugh DS, Schneekloth JS. Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angewandte Chemie (International Ed. in English). PMID 27038327 DOI: 10.1002/Anie.201511351  0.392
2016 Leon EC, Simmons JK, Calabrese D, DuBois W, Felsenstein K, Saunders LB, Zhang S, Michalowski A, Gonzalez F, Mock BA, Schneekloth JS. Abstract 322: Selective inhibition of MYC expression by a small molecule G-quadruplex stabilizer Cancer Research. 76: 322-322. DOI: 10.1158/1538-7445.Am2016-322  0.374
2015 Felsenstein KM, Saunders LB, Simmons JK, Leon E, Calabrese D, Zhang S, Michalowski A, Gareiss P, Mock BA, Schneekloth JS. Small Molecule Microarrays Enable the Identification of a Selective, Quadruplex-Binding Inhibitor of MYC Expression. Acs Chemical Biology. PMID 26462961 DOI: 10.1021/Acschembio.5B00577  0.385
2015 Leyva MJ, Kim YS, Peach ML, Schneekloth JS. Synthetic derivatives of the SUMO consensus sequence provide a basis for improved substrate recognition. Bioorganic & Medicinal Chemistry Letters. 25: 2146-51. PMID 25881829 DOI: 10.1016/J.Bmcl.2015.03.069  0.363
2015 Simmons JK, Saunders LB, Felsenstein K, Gareiss P, Zhang S, Mock B, Schneekloth JS. Abstract B40: Selective suppression of Myc transcription with a G-quadruplex stabilizing small molecule Molecular Cancer Research. 13. DOI: 10.1158/1557-3125.Myc15-B40  0.437
2014 Sztuba-Solinska J, Shenoy SR, Gareiss P, Krumpe LR, Le Grice SF, O'Keefe BR, Schneekloth JS. Identification of biologically active, HIV TAR RNA-binding small molecules using small molecule microarrays. Journal of the American Chemical Society. 136: 8402-10. PMID 24820959 DOI: 10.1021/Ja502754F  0.398
2014 Kim YS, Keyser SG, Schneekloth JS. Synthesis of 2',3',4'-trihydroxyflavone (2-D08), an inhibitor of protein sumoylation. Bioorganic & Medicinal Chemistry Letters. 24: 1094-7. PMID 24468414 DOI: 10.1016/J.Bmcl.2014.01.010  0.362
2013 Kim YS, Nagy K, Keyser S, Schneekloth JS. An electrophoretic mobility shift assay identifies a mechanistically unique inhibitor of protein sumoylation. Chemistry & Biology. 20: 604-13. PMID 23601649 DOI: 10.1016/J.Chembiol.2013.04.001  0.355
2012 Noblin DJ, Page CM, Tae HS, Gareiss PC, Schneekloth JS, Crews CM. A HaloTag-based small molecule microarray screening methodology with increased sensitivity and multiplex capabilities. Acs Chemical Biology. 7: 2055-63. PMID 23013033 DOI: 10.1021/Cb300453K  0.623
2011 Schneekloth JS, Crews CM. Natural product inhibitors of the ubiquitin-proteasome pathway. Current Drug Targets. 12: 1581-94. PMID 21561423 DOI: 10.2174/138945011798109491  0.502
2007 Petri AF, Schneekloth JS, Mandal AK, Crews CM. Synthesis of the C3-C18 fragment of amphidinolides G and H. Organic Letters. 9: 3001-4. PMID 17616200 DOI: 10.1021/Ol071024E  0.494
2007 Schneekloth JS, Pucheault M, Crews CM. Construction of highly substituted stereodefined dienes by cross-coupling of α-allenic acetates European Journal of Organic Chemistry. 40-43. DOI: 10.1002/Ejoc.200600721  0.654
2006 Schneekloth JS, Sanders JL, Hines J, Crews CM. Neurotrophic peptide aldehydes: solid phase synthesis of fellutamide B and a simplified analog. Bioorganic & Medicinal Chemistry Letters. 16: 3855-8. PMID 16697191 DOI: 10.1016/J.Bmcl.2006.04.029  0.502
2006 Mandal AK, Schneekloth JS, Kuramochi K, Crews CM. Synthetic studies on amphidinolide B1. Organic Letters. 8: 427-30. PMID 16435851 DOI: 10.1021/Ol052620G  0.522
2005 Mandal AK, Schneekloth JS, Crews CM. Stereoselective assembly of a 1,3-diene via coupling between an allenic acetate and a (B)-alkylborane: synthetic studies on amphidinolide B1. Organic Letters. 7: 3645-8. PMID 16092840 DOI: 10.1021/Ol051175M  0.536
2005 Schneekloth JS, Crews CM. Chemical approaches to controlling intracellular protein degradation. Chembiochem : a European Journal of Chemical Biology. 6: 40-6. PMID 15532104 DOI: 10.1002/Cbic.200400274  0.551
2004 Schneekloth JS, Fonseca FN, Koldobskiy M, Mandal A, Deshaies R, Sakamoto K, Crews CM. Chemical genetic control of protein levels: selective in vivo targeted degradation. Journal of the American Chemical Society. 126: 3748-54. PMID 15038727 DOI: 10.1021/Ja039025Z  0.58
2002 Shotwell JB, Krygowski ES, Hines J, Koh B, Huntsman EW, Choi HW, Schneekloth JS, Wood JL, Crews CM. Total synthesis of luminacin D. Organic Letters. 4: 3087-9. PMID 12201723 DOI: 10.1021/Ol026382Q  0.529
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