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Doryen A. Bubeck, Ph.D. - Publications

Affiliations: 
2005 Harvard University, Cambridge, MA, United States 
Area:
structural biology
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31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Couves EC, Gardner S, Voisin TB, Bickel JK, Stansfeld PJ, Tate EW, Bubeck D. Structural basis for membrane attack complex inhibition by CD59. Nature Communications. 14: 890. PMID 36797260 DOI: 10.1038/s41467-023-36441-z  0.391
2022 Couves EC, Bubeck D. Capturing pore-forming intermediates of MACPF and binary toxin assemblies by cryoEM. Current Opinion in Structural Biology. 75: 102401. PMID 35700576 DOI: 10.1016/j.sbi.2022.102401  0.363
2021 Menny A, Lukassen MV, Couves EC, Franc V, Heck AJR, Bubeck D. Structural basis of soluble membrane attack complex packaging for clearance. Nature Communications. 12: 6086. PMID 34667172 DOI: 10.1038/s41467-021-26366-w  0.425
2021 Bickel JK, Voisin TB, Tate EW, Bubeck D. How Structures of Complement Complexes Guide Therapeutic Design. Sub-Cellular Biochemistry. 96: 273-295. PMID 33252733 DOI: 10.1007/978-3-030-58971-4_7  0.445
2020 Barnum SR, Bubeck D, Schein TN. Soluble Membrane Attack Complex: Biochemistry and Immunobiology. Frontiers in Immunology. 11: 585108. PMID 33240274 DOI: 10.3389/fimmu.2020.585108  0.353
2020 Shah NR, Voisin TB, Parsons ES, Boyd CM, Hoogenboom BW, Bubeck D. Structural basis for tuning activity and membrane specificity of bacterial cytolysins. Nature Communications. 11: 5818. PMID 33199689 DOI: 10.1038/s41467-020-19482-6  0.395
2019 McFarlane CR, Shah NR, Kabasakal BV, Echeverria B, Cotton CAR, Bubeck D, Murray JW. Structural basis of light-induced redox regulation in the Calvin-Benson cycle in cyanobacteria. Proceedings of the National Academy of Sciences of the United States of America. PMID 31570616 DOI: 10.1073/Pnas.1906722116  0.34
2019 Parsons ES, Stanley GJ, Pyne ALB, Hodel AW, Nievergelt AP, Menny A, Yon AR, Rowley A, Richter RP, Fantner GE, Bubeck D, Hoogenboom BW. Single-molecule kinetics of pore assembly by the membrane attack complex. Nature Communications. 10: 2066. PMID 31061395 DOI: 10.1038/S41467-019-10058-7  0.476
2018 Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Morgan BP, Topf M, Brooks NJ, Bubeck D. CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers. Nature Communications. 9: 5316. PMID 30552328 DOI: 10.2210/Pdb6H04/Pdb  0.534
2018 Boyd CM, Bubeck D. Advances in cryoEM and its impact on β-pore forming proteins. Current Opinion in Structural Biology. 52: 41-49. PMID 30125772 DOI: 10.1016/J.Sbi.2018.07.010  0.396
2017 Morgan BP, Boyd C, Bubeck D. Molecular cell biology of complement membrane attack. Seminars in Cell & Developmental Biology. PMID 28647534 DOI: 10.1016/J.Semcdb.2017.06.009  0.443
2017 Bayly-Jones C, Bubeck D, Dunstone MA. The mystery behind membrane insertion: a review of the complement membrane attack complex. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 372. PMID 28630159 DOI: 10.1098/Rstb.2016.0221  0.519
2017 Boyd C, Serna M, Gardner S, Praveen-Joseph A, Topf M, Morgan BP, Bubeck D. Unravelling the Mechanism of Membrane Attack Complex Pore Closure Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.1812  0.483
2016 Boyd CM, Parsons ES, Smith RA, Seddon JM, Ces O, Bubeck D. Disentangling the roles of cholesterol and CD59 in intermedilysin pore formation. Scientific Reports. 6: 38446. PMID 27910935 DOI: 10.1038/Srep38446  0.423
2016 Morgan BP, Walters D, Serna M, Bubeck D. Terminal complexes of the complement system: new structural insights and their relevance to function. Immunological Reviews. 274: 141-151. PMID 27782334 DOI: 10.1111/Imr.12461  0.514
2016 Serna M, Giles JL, Morgan BP, Bubeck D. Structural basis of complement membrane attack complex formation. Nature Communications. 7: 10587. PMID 26841837 DOI: 10.1038/Ncomms10587  0.516
2016 Morgan BP, Serna M, Bubeck D. Complex beauty complements membrane attack Immunobiology. 221: 1194. DOI: 10.1016/J.Imbio.2016.06.153  0.482
2014 Bubeck D. The making of a macromolecular machine: assembly of the membrane attack complex. Biochemistry. 53: 1908-15. PMID 24597946 DOI: 10.1021/Bi500157Z  0.498
2013 Johnson S, Brooks NJ, Smith RA, Lea SM, Bubeck D. Structural basis for recognition of the pore-forming toxin intermedilysin by human complement receptor CD59. Cell Reports. 3: 1369-77. PMID 23665225 DOI: 10.1016/J.Celrep.2013.04.029  0.398
2012 Hadders MA, Bubeck D, Roversi P, Hakobyan S, Forneris F, Morgan BP, Pangburn MK, Llorca O, Lea SM, Gros P. Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9. Cell Reports. 1: 200-7. PMID 22832194 DOI: 10.1016/J.Celrep.2012.02.003  0.496
2011 Chen S, Bubeck D, MacDonald BT, Liang WX, Mao JH, Malinauskas T, Llorca O, Aricescu AR, Siebold C, He X, Jones EY. Structural and functional studies of LRP6 ectodomain reveal a platform for Wnt signaling. Developmental Cell. 21: 848-61. PMID 22000855 DOI: 10.1016/J.Devcel.2011.09.007  0.399
2011 Reijns MA, Bubeck D, Gibson LC, Graham SC, Baillie GS, Jones EY, Jackson AP. The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease. The Journal of Biological Chemistry. 286: 10530-9. PMID 21177854 DOI: 10.1074/Jbc.M110.177394  0.326
2011 Bubeck D, Roversi P, Donev R, Morgan BP, Llorca O, Lea SM. Structure of human complement C8, a precursor to membrane attack. Journal of Molecular Biology. 405: 325-30. PMID 21073882 DOI: 10.1016/J.Jmb.2010.10.031  0.507
2008 Bubeck D, Filman DJ, Kuzmin M, Fuller SD, Hogle JM. Post-imaging fiducial markers aid in the orientation determination of complexes with mixed or unknown symmetry. Journal of Structural Biology. 162: 480-90. PMID 18442921 DOI: 10.1016/J.Jsb.2008.03.006  0.655
2007 Bostina M, Bubeck D, Schwartz C, Nicastro D, Filman DJ, Hogle JM. Single particle cryoelectron tomography characterization of the structure and structural variability of poliovirus-receptor-membrane complex at 30 A resolution. Journal of Structural Biology. 160: 200-10. PMID 17897840 DOI: 10.1016/J.Jsb.2007.08.009  0.651
2007 Bubeck D, Roversi P, Donev R, Hepburn NJ, Leath K, Jones EY, Morgan BP, Lea SM. Structural analysis of the soluble C5b-9 complex using cryo-electron microscopy Molecular Immunology. 44: 3981-3982. DOI: 10.1016/J.Molimm.2007.06.189  0.371
2006 Huiskonen JT, de Haas F, Bubeck D, Bamford DH, Fuller SD, Butcher SJ. Structure of the bacteriophage phi6 nucleocapsid suggests a mechanism for sequential RNA packaging. Structure (London, England : 1993). 14: 1039-48. PMID 16765897 DOI: 10.1016/J.Str.2006.03.018  0.366
2006 Tuthill TJ, Bubeck D, Rowlands DJ, Hogle JM. Characterization of early steps in the poliovirus infection process: receptor-decorated liposomes induce conversion of the virus to membrane-anchored entry-intermediate particles. Journal of Virology. 80: 172-80. PMID 16352541 DOI: 10.1128/Jvi.80.1.172-180.2006  0.64
2005 Bubeck D, Filman DJ, Hogle JM. Cryo-electron microscopy reconstruction of a poliovirus-receptor-membrane complex. Nature Structural & Molecular Biology. 12: 615-8. PMID 15965485 DOI: 10.1038/Nsmb955  0.671
2005 Bubeck D, Filman DJ, Cheng N, Steven AC, Hogle JM, Belnap DM. The structure of the poliovirus 135S cell entry intermediate at 10-angstrom resolution reveals the location of an externalized polypeptide that binds to membranes. Journal of Virology. 79: 7745-55. PMID 15919927 DOI: 10.1128/Jvi.79.12.7745-7755.2005  0.626
1997 Beckmann R, Bubeck D, Grassucci R, Penczek P, Verschoor A, Blobel G, Frank J. Alignment of conduits for the nascent polypeptide chain in the ribosome-Sec61 complex. Science (New York, N.Y.). 278: 2123-6. PMID 9405348 DOI: 10.1126/Science.278.5346.2123  0.436
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