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Christian Haass, PhD, University of Heidelberg 1989 - Publications

Affiliations: 
Biochemistry Ludwig-Maximilians-Universität München, München, Bayern, Germany 
Area:
http://www.researchprofiles.collexis.com/jad/expert.asp?n=&u_id=25
Website:
http://www.cipsm.de/en/aboutCIPSM/members/haassChristian/index.html?style=0
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405 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Zatcepin A, Gnörich J, Rauchmann BS, Bartos LM, Wagner S, Franzmeier N, Malpetti M, Xiang X, Shi Y, Parhizkar S, Grosch M, Wind-Mark K, Kunte ST, Beyer L, Meyer C, ... ... Haass C, et al. Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer's disease. Molecular Neurodegeneration. 19: 64. PMID 39238030 DOI: 10.1186/s13024-024-00752-6  0.646
2024 Parhizkar S, Arzberger T, Brendel M, Kleinberger G, Deussing M, Focke C, Nuscher B, Xiong M, Ghasemigharagoz A, Katzmarski N, Krasemann S, Lichtenthaler SF, Müller SA, Colombo A, Monasor LS, ... ... Haass C, et al. Author Correction: Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE. Nature Neuroscience. PMID 39143410 DOI: 10.1038/s41593-024-01752-x  0.691
2024 Hu Y, Hruscha A, Pan C, Schifferer M, Schmidt MK, Nuscher B, Giera M, Kostidis S, Burhan Ö, van Bebber F, Edbauer D, Arzberger T, Haass C, Schmid B. Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits. Molecular Neurodegeneration. 19: 50. PMID 38902734 DOI: 10.1186/s13024-024-00735-7  0.548
2024 Ramalingam N, Haass C, Dettmer U. Physiological roles of α-synuclein serine-129 phosphorylation - not an oxymoron. Trends in Neurosciences. 47: 480-490. PMID 38862330 DOI: 10.1016/j.tins.2024.05.005  0.792
2024 Riemenschneider H, Guo Q, Bader J, Frottin F, Farny D, Kleinberger G, Haass C, Mann M, Hartl FU, Baumeister W, Hipp MS, Meissner F, Fernández-Busnadiego R, Edbauer D. Author Correction: Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons. Embo Reports. PMID 38849674 DOI: 10.1038/s44319-024-00163-0  0.544
2024 Reich M, Simon MJ, Polke B, Paris I, Werner G, Schrader C, Spieth L, Davis SS, Robinson S, de Melo GL, Schlaphoff L, Buschmann K, Berghoff S, Logan T, Nuscher B, ... ... Haass C, et al. Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration. Science Translational Medicine. 16: eadj7308. PMID 38838131 DOI: 10.1126/scitranslmed.adj7308  0.586
2023 Palleis C, Franzmeier N, Weidinger E, Bernhardt AM, Katzdobler S, Wall S, Ferschmann C, Harris S, Schmitt J, Schuster S, Gnörich J, Finze A, Biechele G, Lindner S, Albert NL, ... ... Haass C, et al. Association of Neurofilament Light Chain, [F]PI-2620 Tau-PET, TSPO-PET, and Clinical Progression in Patients With β-Amyloid-Negative CBS. Neurology. 102: e207901. PMID 38165362 DOI: 10.1212/WNL.0000000000207901  0.526
2023 Schlepckow K, Morenas-Rodríguez E, Hong S, Haass C. Stimulation of TREM2 with agonistic antibodies-an emerging therapeutic option for Alzheimer's disease. The Lancet. Neurology. 22: 1048-1060. PMID 37863592 DOI: 10.1016/S1474-4422(23)00247-8  0.551
2023 Kolabas ZI, Kuemmerle LB, Perneczky R, Förstera B, Ulukaya S, Ali M, Kapoor S, Bartos LM, Büttner M, Caliskan OS, Rong Z, Mai H, Höher L, Jeridi D, Molbay M, ... ... Haass C, et al. Distinct molecular profiles of skull bone marrow in health and neurological disorders. Cell. PMID 37562402 DOI: 10.1016/j.cell.2023.07.009  0.458
2023 Johnson ECB, Bian S, Haque RU, Carter EK, Watson CM, Gordon BA, Ping L, Duong DM, Epstein MP, McDade E, Barthélemy NR, Karch CM, Xiong C, Cruchaga C, Perrin RJ, ... ... Haass C, et al. Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease. Nature Medicine. PMID 37550416 DOI: 10.1038/s41591-023-02476-4  0.327
2023 Finze A, Biechele G, Rauchmann BS, Franzmeier N, Palleis C, Katzdobler S, Weidinger E, Guersel S, Schuster S, Harris S, Schmitt J, Beyer L, Gnörich J, Lindner S, Albert NL, ... ... Haass C, et al. Individual regional associations between Aβ-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies. Molecular Psychiatry. PMID 37495886 DOI: 10.1038/s41380-023-02188-8  0.536
2023 Hipke K, Pitter B, Hruscha A, van Bebber F, Modic M, Bansal V, Lewandowski SA, Orozco D, Edbauer D, Bonn S, Haass C, Pohl U, Montanez E, Schmid B. Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased , and . Frontiers in Cell and Developmental Biology. 11: 1169962. PMID 37384248 DOI: 10.3389/fcell.2023.1169962  0.58
2023 Gnörich J, Reifschneider A, Wind K, Zatcepin A, Kunte ST, Beumers P, Bartos LM, Wiedemann T, Grosch M, Xiang X, Fard MK, Ruch F, Werner G, Koehler M, Slemann L, ... ... Haass C, et al. Depletion and activation of microglia impact metabolic connectivity of the mouse brain. Journal of Neuroinflammation. 20: 47. PMID 36829182 DOI: 10.1186/s12974-023-02735-8  0.588
2023 van Lengerich B, Zhan L, Xia D, Chan D, Joy D, Park JI, Tatarakis D, Calvert M, Hummel S, Lianoglou S, Pizzo ME, Prorok R, Thomsen E, Bartos LM, Beumers P, ... ... Haass C, et al. A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models. Nature Neuroscience. PMID 36635496 DOI: 10.1038/s41593-022-01240-0  0.517
2023 Biel D, Suárez-Calvet M, Hager P, Rubinski A, Dewenter A, Steward A, Roemer S, Ewers M, Haass C, Brendel M, Franzmeier N. sTREM2 is associated with amyloid-related p-tau increases and glucose hypermetabolism in Alzheimer's disease. Embo Molecular Medicine. e16987. PMID 36620941 DOI: 10.15252/emmm.202216987  0.561
2022 Paolicelli RC, Sierra A, Stevens B, Tremblay ME, Aguzzi A, Ajami B, Amit I, Audinat E, Bechmann I, Bennett M, Bennett F, Bessis A, Biber K, Bilbo S, Blurton-Jones M, ... ... Haass C, et al. Microglia states and nomenclature: A field at its crossroads. Neuron. 110: 3458-3483. PMID 36327895 DOI: 10.1016/j.neuron.2022.10.020  0.665
2022 Xiang X, Tahirovic S, Ziegler S, Haass C, Brendel M. Response to Comment on "Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases". Science Translational Medicine. 14: eabn5104. PMID 36001676 DOI: 10.1126/scitranslmed.abn5104  0.595
2022 Xia D, Lianoglou S, Sandmann T, Calvert M, Suh JH, Thomsen E, Dugas J, Pizzo ME, DeVos SL, Earr TK, Lin CC, Davis S, Ha C, Leung AW, Nguyen H, ... ... Haass C, et al. Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia. Molecular Neurodegeneration. 17: 41. PMID 35690868 DOI: 10.1186/s13024-022-00547-7  0.535
2022 Bartos LM, Kunte ST, Beumers P, Xiang X, Wind K, Ziegler S, Bartenstein P, Choi H, Lee DS, Haass C, von Baumgarten L, Tahirovic S, Albert NL, Lindner S, Brendel M. Single cell radiotracer allocation via immunomagentic sorting (scRadiotracing) to disentangle PET signals at cellular resolution. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 35589403 DOI: 10.2967/jnumed.122.264171  0.587
2022 Riemenschneider H, Guo Q, Bader J, Frottin F, Farny D, Kleinberger G, Haass C, Mann M, Hartl FU, Baumeister W, Hipp MS, Meissner F, Fernández-Busnadiego R, Edbauer D. Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons. Embo Reports. e53890. PMID 35438230 DOI: 10.15252/embr.202153890  0.629
2022 Reifschneider A, Robinson S, van Lengerich B, Gnörich J, Logan T, Heindl S, Vogt MA, Weidinger E, Riedl L, Wind K, Zatcepin A, Pesämaa I, Haberl S, Nuscher B, Kleinberger G, ... ... Haass C, et al. Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency. The Embo Journal. e109108. PMID 35019161 DOI: 10.15252/embj.2021109108  0.492
2021 Xiang X, Wind K, Wiedemann T, Blume T, Shi Y, Briel N, Beyer L, Biechele G, Eckenweber F, Zatcepin A, Lammich S, Ribicic S, Tahirovic S, Willem M, Deussing M, ... ... Haass C, et al. Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases. Science Translational Medicine. 13: eabe5640. PMID 34644146 DOI: 10.1126/scitranslmed.abe5640  0.591
2021 Mori K, Gotoh S, Yamashita T, Uozumi R, Kawabe Y, Tagami S, Kamp F, Nuscher B, Edbauer D, Haass C, Nagai Y, Ikeda M. The porphyrin TMPyP4 inhibits elongation during the non-canonical translation of the FTLD/ALS-associated GGGGCC repeat in the C9orf72 gene. The Journal of Biological Chemistry. 101120. PMID 34450161 DOI: 10.1016/j.jbc.2021.101120  0.558
2021 Joshi P, Riffel F, Satoh K, Enomoto M, Qamar S, Scheiblich H, Villacampa N, Kumar S, Theil S, Parhizkar S, Haass C, Heneka MT, Fraser PE, St George-Hyslop P, Walter J. Differential interaction with TREM2 modulates microglial uptake of modified Aβ species. Glia. PMID 34427354 DOI: 10.1002/glia.24077  0.321
2021 Vettermann FJ, Harris S, Schmitt J, Unterrainer M, Lindner S, Rauchmann BS, Palleis C, Weidinger E, Beyer L, Eckenweber F, Schuster S, Biechele G, Ferschmann C, Milenkovic VM, Wetzel CH, ... ... Haass C, et al. Impact of TSPO Receptor Polymorphism on [F]GE-180 Binding in Healthy Brain and Pseudo-Reference Regions of Neurooncological and Neurodegenerative Disorders. Life (Basel, Switzerland). 11. PMID 34073557 DOI: 10.3390/life11060484  0.46
2021 Schmitt J, Palleis C, Sauerbeck J, Unterrainer M, Harris S, Prix C, Weidinger E, Katzdobler S, Wagemann O, Danek A, Beyer L, Rauchmann BS, Rominger A, Simons M, Bartenstein P, ... ... Haass C, et al. Dual-Phase β-Amyloid PET Captures Neuronal Injury and Amyloidosis in Corticobasal Syndrome. Frontiers in Aging Neuroscience. 13: 661284. PMID 34054506 DOI: 10.3389/fnagi.2021.661284  0.493
2021 Biechele G, Sebastian Monasor L, Wind K, Blume T, Parhizkar S, Arzberger T, Sacher C, Beyer L, Eckenweber F, Gildehaus FJ, von Ungern-Sternberg B, Willem M, Bartenstein P, Cumming P, Rominger A, ... ... Haass C, et al. Glitter in the Darkness? Non-fibrillar β-amyloid Plaque Components Significantly Impact the β-amyloid PET Signal in Mouse Models of Alzheimer's Disease. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 34016733 DOI: 10.2967/jnumed.120.261858  0.542
2021 Palleis C, Brendel M, Finze A, Weidinger E, Bötzel K, Danek A, Beyer L, Nitschmann A, Kern M, Biechele G, Rauchmann BS, Häckert J, Höllerhage M, Stephens AW, Drzezga A, ... ... Haass C, et al. Cortical [ F]PI-2620 Binding Differentiates Corticobasal Syndrome Subtypes. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33951244 DOI: 10.1002/mds.28624  0.46
2021 Haass C. Loss of TREM2 facilitates tau accumulation, spreading, and brain atrophy, but only in the presence of amyloid pathology. Neuron. 109: 1243-1245. PMID 33887187 DOI: 10.1016/j.neuron.2021.03.029  0.312
2021 Nuebling GS, Prix C, Brendel M, Beyer L, Wlasich E, Loosli SV, Barthel H, Sabri O, Bartenstein P, Vöglein J, Danek A, Rominger A, Edbauer D, Haass C, Levin J. Low-degree trisomy 21 mosaicism promotes early-onset Alzheimer disease. Neurobiology of Aging. PMID 33789815 DOI: 10.1016/j.neurobiolaging.2021.02.021  0.715
2020 Palleis C, Sauerbeck J, Beyer L, Harris S, Schmitt J, Morenas-Rodriguez E, Finze A, Nitschmann A, Ruch-Rubinstein F, Eckenweber F, Biechele G, Blume T, Shi Y, Weidinger E, Prix C, ... ... Haass C, et al. In Vivo Assessment of Neuroinflammation in 4-Repeat Tauopathies. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33245166 DOI: 10.1002/mds.28395  0.443
2020 Franzmeier N, Suárez-Calvet M, Frontzkowski L, Moore A, Hohman TJ, Morenas-Rodriguez E, Nuscher B, Shaw L, Trojanowski JQ, Dichgans M, Kleinberger G, Haass C, Ewers M. Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration. Molecular Neurodegeneration. 15: 57. PMID 33032659 DOI: 10.1186/s13024-020-00407-2  0.373
2020 Werner G, Damme M, Schludi M, Gnörich J, Wind K, Fellerer K, Wefers B, Wurst W, Edbauer D, Brendel M, Haass C, Capell A. Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice. Embo Reports. e50241. PMID 32929860 DOI: 10.15252/Embr.202050241  0.72
2020 Takalo M, Wittrahm R, Wefers B, Parhizkar S, Jokivarsi K, Kuulasmaa T, Mäkinen P, Martiskainen H, Wurst W, Xiang X, Marttinen M, Poutiainen P, Haapasalo A, Hiltunen M, Haass C. The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions. Molecular Neurodegeneration. 15: 52. PMID 32917267 DOI: 10.1186/S13024-020-00402-7  0.562
2020 Steiner A, Schlepckow K, Brunner B, Steiner H, Haass C, Hagn F. γ-Secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics. The Embo Journal. e104247. PMID 32830336 DOI: 10.15252/Embj.2019104247  0.331
2020 Ewers M, Biechele G, Suárez-Calvet M, Sacher C, Blume T, Morenas-Rodriguez E, Deming Y, Piccio L, Cruchaga C, Kleinberger G, Shaw L, Trojanowski JQ, Herms J, Dichgans M, ... ... Haass C, et al. Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation. Embo Molecular Medicine. e12308. PMID 32790063 DOI: 10.15252/Emmm.202012308  0.784
2020 Sebastian Monasor L, Müller SA, Colombo AV, Tanrioever G, König J, Roth S, Liesz A, Berghofer A, Piechotta A, Prestel M, Saito T, Saido TC, Herms J, Willem M, Haass C, et al. Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models. Elife. 9. PMID 32510331 DOI: 10.7554/Elife.54083  0.422
2020 Sacher C, Blume T, Beyer L, Biechele G, Sauerbeck J, Eckenweber F, Deussing M, Focke C, Parhizkar S, Lindner S, Gildehaus FJ, von Ungern-Sternberg B, Baumann K, Tahirovic S, Kleinberger G, ... ... Haass C, et al. Asymmetry of fibrillar plaque burden in amyloid mouse models. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 32414948 DOI: 10.2967/Jnumed.120.242750  0.596
2020 Berner DK, Wessolowski L, Armbrust F, Schneppenheim J, Schlepckow K, Koudelka T, Scharfenberg F, Lucius R, Tholey A, Kleinberger G, Haass C, Arnold P, Becker-Pauly C. Meprin β cleaves TREM2 and controls its phagocytic activity on macrophages. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32237095 DOI: 10.1096/Fj.201902183R  0.317
2020 Schlepckow K, Monroe KM, Kleinberger G, Cantuti-Castelvetri L, Parhizkar S, Xia D, Willem M, Werner G, Pettkus N, Brunner B, Sülzen A, Nuscher B, Hampel H, Xiang X, Feederle R, ... ... Haass C, et al. Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region. Embo Molecular Medicine. e11227. PMID 32154671 DOI: 10.15252/Emmm.201911227  0.555
2020 Monasor LS, Müller SA, Colombo AV, Tanrioever G, König J, Roth S, Liesz A, Berghofer A, Piechotta A, Prestel M, Saito T, Saido TC, Herms J, Willem M, Haass C, et al. Author response: Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models Elife. DOI: 10.7554/Elife.54083.Sa2  0.374
2019 Zhou Q, Mareljic N, Michaelsen M, Parhizkar S, Heindl S, Nuscher B, Farny D, Czuppa M, Schludi C, Graf A, Krebs S, Blum H, Feederle R, Roth S, Haass C, et al. Active poly-GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model. Embo Molecular Medicine. e10919. PMID 31858749 DOI: 10.15252/Emmm.201910919  0.571
2019 Nihei Y, Mori K, Werner G, Arzberger T, Zhou Q, Khosravi B, Japtok J, Hermann A, Sommacal A, Weber M, Kamp F, Nuscher B, Edbauer D, ... Haass C, et al. Poly-glycine-alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3. Acta Neuropathologica. PMID 31642962 DOI: 10.1007/S00401-019-02082-0  0.584
2019 Vöglein J, Willem M, Trambauer J, Schönecker S, Dieterich M, Biskup S, Giudici C, Utz K, Oberstein T, Brendel M, Rominger A, Danek A, Steiner H, Haass C, Levin J. Identification of a rare presenilin 1 single amino acid deletion mutation (F175del) with unusual amyloid-β processing effects. Neurobiology of Aging. PMID 31627977 DOI: 10.1016/J.Neurobiolaging.2019.08.034  0.598
2019 Jessen F, Haass C. [Quo vadis Alzheimer?] Der Nervenarzt. 90: 881-883. PMID 31493046 DOI: 10.1007/S00115-019-0771-X  0.383
2019 Ewers M, Franzmeier N, Suárez-Calvet M, Morenas-Rodriguez E, Caballero MAA, Kleinberger G, Piccio L, Cruchaga C, Deming Y, Dichgans M, Trojanowski JQ, Shaw LM, Weiner MW, Haass C. Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease. Science Translational Medicine. 11. PMID 31462511 DOI: 10.1126/Scitranslmed.Aav6221  0.712
2019 Deming Y, Filipello F, Cignarella F, Cantoni C, Hsu S, Mikesell R, Li Z, Del-Aguila JL, Dube U, Farias FG, Bradley J, Budde J, Ibanez L, Fernandez MV, Blennow K, ... ... Haass C, et al. The gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk. Science Translational Medicine. 11. PMID 31413141 DOI: 10.1126/Scitranslmed.Aau2291  0.7
2019 Haass C, Levin J. [Did Alzheimer research fail entirely? : Failure of amyloid-based clinical studies]. Der Nervenarzt. PMID 31243509 DOI: 10.1007/S00115-019-0751-1  0.435
2019 Morenas-Rodríguez E, Alcolea D, Suárez-Calvet M, Muñoz-Llahuna L, Vilaplana E, Sala I, Subirana A, Querol-Vilaseca M, Carmona-Iragui M, Illán-Gala I, Ribosa-Nogué R, Blesa R, Haass C, Fortea J, Lleó A. Different pattern of CSF glial markers between dementia with Lewy bodies and Alzheimer's disease. Scientific Reports. 9: 7803. PMID 31127154 DOI: 10.1038/S41598-019-44173-8  0.357
2019 Götzl JK, Brendel M, Werner G, Parhizkar S, Sebastian Monasor L, Kleinberger G, Colombo AV, Deussing M, Wagner M, Winkelmann J, Diehl-Schmid J, Levin J, Fellerer K, Reifschneider A, Bultmann S, ... ... Haass C, et al. Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism. Embo Molecular Medicine. PMID 31122931 DOI: 10.15252/Emmm.201809711  0.567
2019 Katzmarski N, Ziegler-Waldkirch S, Scheffler N, Witt C, Abou-Ajram C, Nuscher B, Prinz M, Haass C, Meyer-Luehmann M. Aβ oligomers trigger and accelerate Aβ seeding. Brain Pathology (Zurich, Switzerland). PMID 31099449 DOI: 10.1111/Bpa.12734  0.405
2019 Franzmeier N, Ren J, Damm A, Monté-Rubio G, Boada M, Ruiz A, Ramirez A, Jessen F, Düzel E, Rodríguez Gómez O, Benzinger T, Goate A, Karch CM, Fagan AM, McDade E, ... ... Haass C, et al. The BDNF SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease. Molecular Psychiatry. PMID 30899092 DOI: 10.1038/S41380-019-0404-6  0.35
2019 Vöglein J, Paumier K, Jucker M, Preische O, McDade E, Hassenstab J, Benzinger TL, Noble JM, Berman SB, Graff-Radford NR, Ghetti B, Farlow MR, Chhatwal J, Salloway S, Xiong C, ... ... Haass C, et al. Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer's disease. Brain : a Journal of Neurology. PMID 30897203 DOI: 10.1093/Brain/Awz050  0.341
2019 van Well EM, Bader V, Patra M, Sánchez-Vicente A, Meschede J, Furthmann N, Schnack C, Blusch A, Longworth J, Petrasch-Parwez E, Mori K, Arzberger T, Trümbach D, Angersbach L, Showkat C, ... ... Haass C, et al. A protein quality control pathway regulated by linear ubiquitination. The Embo Journal. PMID 30886048 DOI: 10.15252/Embj.2018100730  0.368
2019 Haass C, Willem M. Secreted APP Modulates Synaptic Activity: A Novel Target for Therapeutic Intervention? Neuron. 101: 557-559. PMID 30790537 DOI: 10.1016/J.Neuron.2019.01.058  0.374
2019 Suárez-Calvet M, Morenas-Rodríguez E, Kleinberger G, Schlepckow K, Caballero MÁA, Franzmeier N, Capell A, Fellerer K, Nuscher B, Eren E, Levin J, Deming Y, Piccio L, Karch CM, Cruchaga C, ... ... Haass C, et al. Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology. Molecular Neurodegeneration. 14: 1. PMID 30630532 DOI: 10.1186/S13024-018-0301-5  0.739
2019 Parhizkar S, Arzberger T, Brendel M, Kleinberger G, Deussing M, Focke C, Nuscher B, Xiong M, Ghasemigharagoz A, Katzmarski N, Krasemann S, Lichtenthaler SF, Müller SA, Colombo A, Monasor LS, ... ... Haass C, et al. Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE. Nature Neuroscience. PMID 30617257 DOI: 10.1038/S41593-018-0296-9  0.737
2019 Eninger T, Müller SA, Bacioglu M, Schweighauser M, Maia LF, Lambert M, Kleinberger G, Haass C, Kahle PJ, Staufenbiel M, Lichtenthaler S, Jucker M, Kaeser SA. P4-544: Deep Proteome Analysis In Cerebrospinal Fluid Of Mouse Models For Neurodegenerative Diseases Suggests A Panel Of Novel Biomarkers Related To Microglia Activation Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.08.091  0.312
2019 Ewers M, Franzmeier N, Suárez-Calvet M, Morenas E, Piccio L, Cruchaga C, Robles Y, Trojanowski JQ, Shaw LM, Weiner MW, Haass C. O3-12-05: Increased Csf Soluble Trem2 Is Associated With Ameliorated Longitudinal Cognitive And Clinical Decline In Alzheimer'S Disease Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.4694  0.425
2018 Suárez-Calvet M, Capell A, Araque Caballero MÁ, Morenas-Rodríguez E, Fellerer K, Franzmeier N, Kleinberger G, Eren E, Deming Y, Piccio L, Karch CM, Cruchaga C, Paumier K, Bateman RJ, Fagan AM, ... ... Haass C, et al. CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline. Embo Molecular Medicine. PMID 30482868 DOI: 10.15252/Emmm.201809712  0.73
2018 Brendel M, Jaworska A, Overhoff F, Blume T, Probst F, Gildehaus FJ, Bartenstein P, Haass C, Bohrmann B, Herms J, Willem M, Rominger A. Efficacy of chronic BACE1 inhibition in PS2APP mice depends on the regional Aβ deposition rate and plaque burden at treatment initiation. Theranostics. 8: 4957-4968. PMID 30429879 DOI: 10.7150/Thno.27868  0.591
2018 Focke C, Blume T, Zott B, Yuan Shi Y, Deussing M, Peters F, Schmidt C, Kleinberger G, Lindner S, Gildehaus FJ, Beyer L, von Ungern-Sternberg B, Bartenstein P, Ozmen L, Baumann K, ... ... Haass C, et al. Early and longitudinal microglial activation but not amyloid accumulation predict cognitive outcome in PS2APP mice. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 30262517 DOI: 10.2967/Jnumed.118.217703  0.554
2018 Araque Caballero MÁ, Suárez-Calvet M, Duering M, Franzmeier N, Benzinger T, Fagan AM, Bateman RJ, Jack CR, Levin J, Dichgans M, Jucker M, Karch C, Masters CL, Morris JC, Weiner M, ... ... Haass C, et al. White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer's disease. Brain : a Journal of Neurology. PMID 30239611 DOI: 10.1093/Brain/Awy229  0.337
2018 Xiang X, Piers TM, Wefers B, Zhu K, Mallach A, Brunner B, Kleinberger G, Song W, Colonna M, Herms J, Wurst W, Pocock JM, Haass C. The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans. Molecular Neurodegeneration. 13: 49. PMID 30185230 DOI: 10.1186/S13024-018-0280-6  0.573
2018 Götzl JK, Colombo AV, Fellerer K, Reifschneider A, Werner G, Tahirovic S, Haass C, Capell A. Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice. Molecular Neurodegeneration. 13: 48. PMID 30180904 DOI: 10.1186/S13024-018-0281-5  0.379
2018 Brendel M, Yousefi BH, Blume T, Herz M, Focke C, Deussing M, Peters F, Lindner S, von Ungern-Sternberg B, Drzezga A, Bartenstein P, Haass C, Okamura N, Herms J, Yakushev I, et al. Comparison of F-T807 and F-THK5117 PET in a Mouse Model of Tau Pathology. Frontiers in Aging Neuroscience. 10: 174. PMID 29930508 DOI: 10.3389/Fnagi.2018.00174  0.535
2018 Hong W, Wang Z, Liu W, O'Malley TT, Jin M, Willem M, Haass C, Frosch MP, Walsh DM. Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer's disease brain. Acta Neuropathologica. PMID 29687257 DOI: 10.1007/S00401-018-1846-7  0.617
2018 Franzmeier N, Düzel E, Jessen F, Buerger K, Levin J, Duering M, Dichgans M, Haass C, Suárez-Calvet M, Fagan AM, Paumier K, Benzinger T, Masters CL, Morris JC, Perneczky R, et al. Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease. Brain : a Journal of Neurology. PMID 29462334 DOI: 10.1093/Brain/Awy008  0.339
2017 Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O'Loughlin E, Xu Y, Fanek Z, Greco DJ, Smith ST, Tweet G, Humulock Z, Zrzavy T, ... ... Haass C, et al. The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. Immunity. 47: 566-581.e9. PMID 28930663 DOI: 10.1016/J.Immuni.2017.08.008  0.614
2017 Schlepckow K, Kleinberger G, Fukumori A, Feederle R, Lichtenthaler SF, Steiner H, Haass C. An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function. Embo Molecular Medicine. PMID 28855300 DOI: 10.15252/Emmm.201707672  0.384
2017 Blauwendraat C, Wilke C, Simón-Sánchez J, Jansen IE, Reifschneider A, Capell A, Haass C, Castillo-Lizardo M, Biskup S, Maetzler W, Rizzu P, Heutink P, Synofzik M. The wide genetic landscape of clinical frontotemporal dementia: systematic combined sequencing of 121 consecutive subjects. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 28749476 DOI: 10.1038/Gim.2017.102  0.304
2017 Brendel M, Focke C, Blume T, Peters F, Deussing M, Probst F, Jaworska A, Overhoff F, Albert N, Lindner S, von Ungern-Sternberg B, Bartenstein P, Haass C, Kleinberger G, Herms J, et al. Time Courses of Cortical Glucose Metabolism and Microglial Activity Across the Life-Span of Wild-Type Mice: A PET Study. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 28705919 DOI: 10.2967/Jnumed.117.195107  0.52
2017 Kleinberger G, Brendel M, Mracsko E, Wefers B, Groeneweg L, Xiang X, Focke C, Deußing M, Suárez-Calvet M, Mazaheri F, Parhizkar S, Pettkus N, Wurst W, Feederle R, Bartenstein P, ... ... Haass C, et al. The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism. The Embo Journal. PMID 28559417 DOI: 10.15252/Embj.201796516  0.664
2017 Mazaheri F, Snaidero N, Kleinberger G, Madore C, Daria A, Werner G, Krasemann S, Capell A, Trümbach D, Wurst W, Brunner B, Bultmann S, Tahirovic S, Kerschensteiner M, Misgeld T, ... ... Haass C, et al. TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury. Embo Reports. PMID 28483841 DOI: 10.15252/Embr.201743922  0.358
2017 Zhou Q, Lehmer C, Michaelsen M, Mori K, Alterauge D, Baumjohann D, Schludi MH, Greiling J, Farny D, Flatley A, Feederle R, May S, Schreiber F, Arzberger T, Kuhm C, ... ... Haass C, et al. Antibodies inhibit transmission and aggregation of C9orf72 poly-GA dipeptide repeat proteins. Embo Molecular Medicine. PMID 28351931 DOI: 10.15252/Emmm.201607054  0.622
2017 Brendel M, Kleinberger G, Probst F, Jaworska A, Overhoff F, Blume T, Albert NL, Carlsen J, Lindner S, Gildehaus FJ, Ozmen L, Suárez-Calvet M, Bartenstein P, Baumann K, Ewers M, ... ... Haass C, et al. Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis. Frontiers in Aging Neuroscience. 9: 8. PMID 28197095 DOI: 10.3389/Fnagi.2017.00008  0.597
2017 Gispert JD, Monté GC, Suárez-Calvet M, Falcon C, Tucholka A, Rojas S, Rami L, Sánchez-Valle R, Lladó A, Kleinberger G, Haass C, Molinuevo JL. The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2. Alzheimer's & Dementia (Amsterdam, Netherlands). 6: 50-59. PMID 28149943 DOI: 10.1016/J.Dadm.2016.12.002  0.35
2017 Ohki Y, Wenninger-Weinzierl A, Hruscha A, Asakawa K, Kawakami K, Haass C, Edbauer D, Schmid B. Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration. Molecular Neurodegeneration. 12: 6. PMID 28088213 DOI: 10.1186/S13024-016-0146-8  0.627
2017 Haass C. BIOLOGICAL ACTIONS OF TREM2 IN ALZHEIMER'S DISEASE Alzheimer's & Dementia. 13: P1447. DOI: 10.1016/J.Jalz.2017.07.485  0.341
2016 Zhu K, Xiang X, Filser S, Marinković P, Dorostkar MM, Crux S, Neumann U, Shimshek DR, Rammes G, Haass C, Lichtenthaler SF, Gunnersen JM, Herms J. Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6. Biological Psychiatry. PMID 28129943 DOI: 10.1016/J.Biopsych.2016.12.023  0.584
2016 Daria A, Colombo A, Llovera G, Hampel H, Willem M, Liesz A, Haass C, Tahirovic S. Young microglia restore amyloid plaque clearance of aged microglia. The Embo Journal. PMID 28007893 DOI: 10.15252/Embj.201694591  0.417
2016 Suárez-Calvet M, Araque Caballero MÁ, Kleinberger G, Bateman RJ, Fagan AM, Morris JC, Levin J, Danek A, Ewers M, Haass C. Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury. Science Translational Medicine. 8: 369ra178. PMID 27974666 DOI: 10.1126/Scitranslmed.Aag1767  0.375
2016 Haass C, Neumann M. Frontotemporal dementia: from molecular mechanisms to therapy. Journal of Neurochemistry. 138: 3-5. PMID 27502123 DOI: 10.1111/Jnc.13619  0.32
2016 Mori K, Nihei Y, Arzberger T, Zhou Q, Mackenzie IR, Hermann A, Hanisch F, Kamp F, Nuscher B, Orozco D, Edbauer D, Haass C. Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition. Embo Reports. PMID 27461252 DOI: 10.15252/Embr.201541724  0.602
2016 Gispert JD, Suárez-Calvet M, Monté GC, Tucholka A, Falcon C, Rojas S, Rami L, Sánchez-Valle R, Lladó A, Kleinberger G, Haass C, Molinuevo JL. Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27423963 DOI: 10.1016/J.Jalz.2016.06.005  0.354
2016 Xiang X, Werner G, Bohrmann B, Liesz A, Mazaheri F, Capell A, Feederle R, Knuesel I, Kleinberger G, Haass C. TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance. Embo Molecular Medicine. PMID 27402340 DOI: 10.15252/Emmm.201606370  0.591
2016 Götzl JK, Lang CM, Haass C, Capell A. Impaired protein degradation in FTLD and related disorders. Ageing Research Reviews. PMID 27166223 DOI: 10.1016/J.Arr.2016.04.008  0.412
2016 Kretner B, Trambauer J, Fukumori A, Mielke J, Kuhn PH, Kremmer E, Giese A, Lichtenthaler SF, Haass C, Arzberger T, Steiner H. Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease. Embo Molecular Medicine. PMID 26988102 DOI: 10.15252/Emmm.201505952  0.453
2016 Overhoff F, Brendel M, Jaworska A, Korzhova V, Delker A, Probst F, Focke C, Gildehaus FJ, Carlsen J, Baumann K, Haass C, Bartenstein P, Herms J, Rominger A. Automated Spatial Brain Normalization and Hindbrain White Matter Reference Tissue Give Improved [(18)F]-Florbetaben PET Quantitation in Alzheimer's Model Mice. Frontiers in Neuroscience. 10: 45. PMID 26973442 DOI: 10.3389/Fnins.2016.00045  0.545
2016 Suárez-Calvet M, Kleinberger G, Araque Caballero MÁ, Brendel M, Rominger A, Alcolea D, Fortea J, Lleó A, Blesa R, Gispert JD, Sánchez-Valle R, Antonell A, Rami L, Molinuevo JL, Brosseron F, ... ... Haass C, et al. sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers. Embo Molecular Medicine. PMID 26941262 DOI: 10.15252/Emmm.201506123  0.584
2016 Ben Halima S, Mishra S, Raja KM, Willem M, Baici A, Simons K, Brüstle O, Koch P, Haass C, Caflisch A, Rajendran L. Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein. Cell Reports. 14: 2127-41. PMID 26923602 DOI: 10.1016/J.Celrep.2016.01.076  0.382
2016 Brendel M, Jaworska A, Probst F, Overhoff F, Korzhova V, Lindner S, Carlsen J, Bartenstein P, Harada R, Kudo Y, Haass C, van Leuven F, Okamura N, Herms J, Rominger A. microPET Imaging of Tau Pathology with [18F]-THK5117 in two Transgenic Mouse Models. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 26912432 DOI: 10.2967/Jnumed.115.163493  0.551
2016 Brendel M, Probst F, Jaworska A, Overhoff F, Korzhova V, Albert N, Beck R, Lindner S, Gildehaus FJ, Baumann K, Bartenstein P, Kleinberger G, Haass C, Herms J, Rominger A. Glial Activation and Glucose Metabolism in a Transgenic Amyloid Mouse Model: A Triple Tracer PET Study. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 26912428 DOI: 10.2967/Jnumed.115.167858  0.584
2016 Suárez-Calvet M, Neumann M, Arzberger T, Abou-Ajram C, Funk E, Hartmann H, Edbauer D, Kremmer E, Göbl C, Resch M, Bourgeois B, Madl T, Reber S, Jutzi D, Ruepp MD, ... ... Haass C, et al. Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS. Acta Neuropathologica. PMID 26895297 DOI: 10.1007/S00401-016-1544-2  0.614
2016 Busche MA, Staufenbiel M, Willem M, Haass C, Förstl H. [Mechanisms of Alzheimer's disease : Neuronal hyperactivity and hypoactivity as new therapeutic targets]. Der Nervenarzt. PMID 26781314 DOI: 10.1007/S00115-015-0041-5  0.457
2016 Ewers M, Suarez-Calvet M, Caballero MAA, Kleinberger G, Fagan AM, Moulder KL, Benzinger TLS, Haass C. Csf Levels Of Strem2 Are Associated With Greater Frontal Cortical Thickness During Advanced Disease Stages In Autosomal Dominant Alzheimer Disease Alzheimers & Dementia. 12. DOI: 10.1016/J.Jalz.2016.06.145  0.318
2015 Kleinberger G, Capell A, Brouwers N, Fellerer K, Sleegers K, Cruts M, Van Broeckhoven C, Haass C. Reduced secretion and altered proteolytic processing caused by missense mutations in progranulin. Neurobiology of Aging. PMID 26811050 DOI: 10.1016/J.Neurobiolaging.2015.12.014  0.318
2015 Fleck D, Voss M, Brankatschk B, Giudici C, Hampel H, Schwenk B, Edbauer D, Fukumori A, Steiner H, Kremmer E, Haug-Kröeper M, Rossner MJ, Fluhrer R, Willem M, Haass C. Proteolytic processing of Neuregulin 1 type III by three intramembrane cleaving proteases. The Journal of Biological Chemistry. PMID 26574544 DOI: 10.1074/Jbc.M115.697995  0.64
2015 Janssens J, Philtjens S, Kleinberger G, Van Mossevelde S, van der Zee J, Cacace R, Engelborghs S, Sieben A, Banzhaf-Strathmann J, Dillen L, Merlin C, Cuijt I, Robberecht C, Schmid B, Santens P, ... ... Haass C, et al. Investigating the role of filamin C in Belgian patients with frontotemporal dementia linked to GRN deficiency in FTLD-TDP brains. Acta Neuropathologica Communications. 3: 68. PMID 26555887 DOI: 10.1186/S40478-015-0246-7  0.33
2015 Edbauer D, Haass C. An amyloid-like cascade hypothesis for C9orf72 ALS/FTD. Current Opinion in Neurobiology. 36: 99-106. PMID 26555807 DOI: 10.1016/J.Conb.2015.10.009  0.656
2015 Brendel M, Jaworska A, Herms J, Trambauer J, Rötzer C, Gildehaus FJ, Carlsen J, Cumming P, Bylund J, Luebbers T, Bartenstein P, Steiner H, Haass C, Baumann K, Rominger A. Monitoring of chronic γ-secretase modulator treatment by serial amyloid-PET. Molecular Psychiatry. 20: 1141. PMID 26401838 DOI: 10.1038/mp.2015.146  0.485
2015 Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel H, Müller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, ... ... Haass C, et al. η-Secretase processing of APP inhibits neuronal activity in the hippocampus. Nature. PMID 26322584 DOI: 10.1038/Nature14864  0.386
2015 Hyman BT, Growdon JH, Albers MW, Buckner RL, Chhatwal J, Gomez-Isla MT, Haass C, Hudry E, Jack CR, Johnson KA, Khachaturian ZS, Kim DY, Martin JB, Nitsch RM, Rosen BR, et al. Massachusetts Alzheimer's Disease Research Center: Progress and challenges. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26297855 DOI: 10.1016/J.Jalz.2015.06.1887  0.591
2015 Bachhuber T, Katzmarski N, McCarter JF, Loreth D, Tahirovic S, Kamp F, Abou-Ajram C, Nuscher B, Serrano-Pozo A, Müller A, Prinz M, Steiner H, Hyman BT, Haass C, Meyer-Luehmann M. Inhibition of amyloid-β plaque formation by α-synuclein. Nature Medicine. 21: 802-7. PMID 26099047 DOI: 10.1038/Nm.3885  0.387
2015 Kuhn PH, Voss M, Haug-Kröper M, Schröder B, Schepers U, Bräse S, Haass C, Lichtenthaler SF, Fluhrer R. Secretome analysis identifies novel signal Peptide peptidase-like 3 (sppl3) substrates and reveals a role of sppl3 in multiple Golgi glycosylation pathways. Molecular & Cellular Proteomics : McP. 14: 1584-98. PMID 25827571 DOI: 10.1074/Mcp.M115.048298  0.32
2015 Solchenberger B, Russell C, Kremmer E, Haass C, Schmid B. Granulin knock out zebrafish lack frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis pathology. Plos One. 10: e0118956. PMID 25785851 DOI: 10.1371/Journal.Pone.0118956  0.321
2015 Brendel M, Jaworska A, Grießinger E, Rötzer C, Burgold S, Gildehaus FJ, Carlsen J, Cumming P, Baumann K, Haass C, Steiner H, Bartenstein P, Herms J, Rominger A. Cross-sectional comparison of small animal [18F]-florbetaben amyloid-PET between transgenic AD mouse models. Plos One. 10: e0116678. PMID 25706990 DOI: 10.1371/Journal.Pone.0116678  0.549
2015 Schulte EC, Fukumori A, Mollenhauer B, Hor H, Arzberger T, Perneczky R, Kurz A, Diehl-Schmid J, Hüll M, Lichtner P, Eckstein G, Zimprich A, Haubenberger D, Pirker W, Brücke T, ... ... Haass C, et al. Rare variants in β-Amyloid precursor protein (APP) and Parkinson's disease. European Journal of Human Genetics : Ejhg. PMID 25604855 DOI: 10.1038/Ejhg.2014.300  0.314
2015 Jäckel S, Summerer AK, Thömmes CM, Pan X, Voigt A, Schulz JB, Rasse TM, Dormann D, Haass C, Kahle PJ. Nuclear import factor transportin and arginine methyltransferase 1 modify FUS neurotoxicity in Drosophila. Neurobiology of Disease. 74: 76-88. PMID 25447237 DOI: 10.1016/J.Nbd.2014.11.003  0.371
2015 Brendel M, Jaworska A, Herms J, Trambauer J, Rötzer C, Gildehaus FJ, Carlsen J, Cumming P, Bylund J, Luebbers T, Bartenstein P, Steiner H, Haass C, Baumann K, Rominger A. Amyloid-PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment Molecular Psychiatry. DOI: 10.1038/mp.2015.74  0.498
2014 Voss M, Künzel U, Higel F, Kuhn PH, Colombo A, Fukumori A, Haug-Kröper M, Klier B, Grammer G, Seidl A, Schröder B, Obst R, Steiner H, Lichtenthaler SF, Haass C, et al. Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation. The Embo Journal. 33: 2890-905. PMID 25354954 DOI: 10.15252/Embj.201488375  0.311
2014 Kleinberger G, Yamanishi Y, Suárez-Calvet M, Czirr E, Lohmann E, Cuyvers E, Struyfs H, Pettkus N, Wenninger-Weinzierl A, Mazaheri F, Tahirovic S, Lleó A, Alcolea D, Fortea J, Willem M, ... ... Haass C, et al. TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Science Translational Medicine. 6: 243ra86. PMID 24990881 DOI: 10.1126/Scitranslmed.3009093  0.372
2014 Vassar R, Kuhn PH, Haass C, Kennedy ME, Rajendran L, Wong PC, Lichtenthaler SF. Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects. Journal of Neurochemistry. 130: 4-28. PMID 24646365 DOI: 10.1111/Jnc.12715  0.417
2014 Götzl JK, Mori K, Damme M, Fellerer K, Tahirovic S, Kleinberger G, Janssens J, van der Zee J, Lang CM, Kremmer E, Martin JJ, Engelborghs S, Kretzschmar HA, Arzberger T, Van Broeckhoven C, ... Haass C, et al. Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis. Acta Neuropathologica. 127: 845-60. PMID 24619111 DOI: 10.1007/S00401-014-1262-6  0.378
2014 Schwenk BM, Lang CM, Hogl S, Tahirovic S, Orozco D, Rentzsch K, Lichtenthaler SF, Hoogenraad CC, Capell A, Haass C, Edbauer D. The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes. The Embo Journal. 33: 450-67. PMID 24357581 DOI: 10.1002/Embj.201385857  0.589
2014 Liebscher S, Page RM, Käfer K, Winkler E, Quinn K, Goldbach E, Brigham EF, Quincy D, Basi GS, Schenk DB, Steiner H, Bonhoeffer T, Haass C, Meyer-Luehmann M, Hübener M. Chronic γ-secretase inhibition reduces amyloid plaque-associated instability of pre- and postsynaptic structures. Molecular Psychiatry. 19: 937-46. PMID 24061497 DOI: 10.1038/Mp.2013.122  0.426
2014 Brendel M, Delker A, Rötzer C, Böning G, Carlsen J, Cyran C, Mille E, Gildehaus FJ, Cumming P, Baumann K, Steiner H, Haass C, Herms J, Bartenstein P, Rominger A. Impact of partial volume effect correction on cerebral β-amyloid imaging in APP-Swe mice using [(18)F]-florbetaben PET. Neuroimage. 84: 843-53. PMID 24055703 DOI: 10.1016/J.Neuroimage.2013.09.017  0.569
2014 Rominger A, Brendel M, Rötzer C, Gildehaus F, Baumann K, Haass C, Steiner H, Herms J, Bartenstein P. Monitoring Of Long-Term Gamma Secretase Modulation Treatment In App-Swe Mice By Means Of [18F]-Florbetaben Pet Alzheimers & Dementia. 10. DOI: 10.1016/J.Jalz.2014.04.113  0.515
2013 Mori K, Arzberger T, Grässer FA, Gijselinck I, May S, Rentzsch K, Weng SM, Schludi MH, van der Zee J, Cruts M, Van Broeckhoven C, Kremmer E, Kretzschmar HA, Haass C, Edbauer D. Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins. Acta Neuropathologica. 126: 881-93. PMID 24132570 DOI: 10.1007/S00401-013-1189-3  0.628
2013 Mackenzie IR, Arzberger T, Kremmer E, Troost D, Lorenzl S, Mori K, Weng SM, Haass C, Kretzschmar HA, Edbauer D, Neumann M. Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations. Acta Neuropathologica. 126: 859-79. PMID 24096617 DOI: 10.1007/S00401-013-1181-Y  0.634
2013 Panda SK, Wefers B, Ortiz O, Floss T, Schmid B, Haass C, Wurst W, Kühn R. Highly efficient targeted mutagenesis in mice using TALENs. Genetics. 195: 703-13. PMID 23979585 DOI: 10.1534/Genetics.113.156570  0.311
2013 Cheret C, Willem M, Fricker FR, Wende H, Wulf-Goldenberg A, Tahirovic S, Nave KA, Saftig P, Haass C, Garratt AN, Bennett DL, Birchmeier C. Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles. The Embo Journal. 32: 2015-28. PMID 23792428 DOI: 10.1038/Emboj.2013.146  0.315
2013 McCarter JF, Liebscher S, Bachhuber T, Abou-Ajram C, Hübener M, Hyman BT, Haass C, Meyer-Luehmann M. Clustering of plaques contributes to plaque growth in a mouse model of Alzheimer's disease. Acta Neuropathologica. 126: 179-88. PMID 23775142 DOI: 10.1007/S00401-013-1137-2  0.391
2013 Rominger A, Brendel M, Burgold S, Keppler K, Baumann K, Xiong G, Mille E, Gildehaus FJ, Carlsen J, Schlichtiger J, Niedermoser S, Wängler B, Cumming P, Steiner H, Herms J, ... Haass C, et al. Longitudinal assessment of cerebral β-amyloid deposition in mice overexpressing Swedish mutant β-amyloid precursor protein using 18F-florbetaben PET. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 54: 1127-34. PMID 23729696 DOI: 10.2967/Jnumed.112.114660  0.587
2013 Fleck D, van Bebber F, Colombo A, Galante C, Schwenk BM, Rabe L, Hampel H, Novak B, Kremmer E, Tahirovic S, Edbauer D, Lichtenthaler SF, Schmid B, Willem M, Haass C. Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 7856-69. PMID 23637177 DOI: 10.1523/Jneurosci.3372-12.2013  0.627
2013 Bentmann E, Haass C, Dormann D. Stress granules in neurodegeneration--lessons learnt from TAR DNA binding protein of 43 kDa and fused in sarcoma. The Febs Journal. 280: 4348-70. PMID 23587065 DOI: 10.1111/Febs.12287  0.348
2013 Dormann D, Haass C. Fused in sarcoma (FUS): an oncogene goes awry in neurodegeneration. Molecular and Cellular Neurosciences. 56: 475-86. PMID 23557964 DOI: 10.1016/J.Mcn.2013.03.006  0.338
2013 Schmid B, Hruscha A, Hogl S, Banzhaf-Strathmann J, Strecker K, van der Zee J, Teucke M, Eimer S, Hegermann J, Kittelmann M, Kremmer E, Cruts M, Solchenberger B, Hasenkamp L, van Bebber F, ... ... Haass C, et al. Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth. Proceedings of the National Academy of Sciences of the United States of America. 110: 4986-91. PMID 23457265 DOI: 10.1073/Pnas.1218311110  0.616
2013 Hogl S, van Bebber F, Dislich B, Kuhn PH, Haass C, Schmid B, Lichtenthaler SF. Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains. Proteomics. 13: 1519-27. PMID 23457027 DOI: 10.1002/Pmic.201200582  0.389
2013 van Bebber F, Hruscha A, Willem M, Schmid B, Haass C. Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes. Journal of Neurochemistry. 127: 471-81. PMID 23406323 DOI: 10.1111/Jnc.12198  0.457
2013 Mori K, Weng SM, Arzberger T, May S, Rentzsch K, Kremmer E, Schmid B, Kretzschmar HA, Cruts M, Van Broeckhoven C, Haass C, Edbauer D. The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS. Science (New York, N.Y.). 339: 1335-8. PMID 23393093 DOI: 10.1126/Science.1232927  0.627
2013 Mori K, Lammich S, Mackenzie IR, Forné I, Zilow S, Kretzschmar H, Edbauer D, Janssens J, Kleinberger G, Cruts M, Herms J, Neumann M, Van Broeckhoven C, Arzberger T, Haass C. hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations. Acta Neuropathologica. 125: 413-23. PMID 23381195 DOI: 10.1007/S00401-013-1088-7  0.618
2013 Kragh CL, Fillon G, Gysbers A, Hansen HD, Neumann M, Richter-Landsberg C, Haass C, Zalc B, Lubetzki C, Gai WP, Halliday GM, Kahle PJ, Jensen PH. FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy. Plos One. 8: e55243. PMID 23372841 DOI: 10.1371/Journal.Pone.0055243  0.349
2013 Kleinberger G, Capell A, Haass C, Van Broeckhoven C. Mechanisms of granulin deficiency: lessons from cellular and animal models. Molecular Neurobiology. 47: 337-60. PMID 23239020 DOI: 10.1007/S12035-012-8380-8  0.341
2013 Kretner B, Fukumori A, Kuhn PH, Pérez-Revuelta BI, Lichtenthaler SF, Haass C, Steiner H. Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase. Journal of Neurochemistry. 125: 144-56. PMID 23237322 DOI: 10.1111/Jnc.12124  0.382
2013 Haass C. The biological function of β-secretase Molecular Neurodegeneration. 8: O5. DOI: 10.1186/1750-1326-8-S1-O5  0.341
2013 Bachhuber T, McCarter J, Tahirovic S, Nuscher B, Kamp F, Abou-Ajram C, Serrano-Pozo A, Hyman B, Haass C, Meyer-Luehmann M. Cross-inhibition of beta-amyloid plaque formation by alpha-synuclein Alzheimers & Dementia. 9. DOI: 10.1016/J.Jalz.2013.05.1398  0.365
2013 Brendel M, Böning G, Delker A, Rötzer C, Gildehaus F, Baumann K, Steiner H, Haass C, Herms J, Bartenstein P, Rominger A. PET imaging using [18F]florbetaben in Alzheimer's disease mouse models Alzheimers & Dementia. 9: 29. DOI: 10.1016/J.Jalz.2013.05.041  0.54
2013 Haass C, van Bebber F, Hruscha A, Willem M, Schmid B. O1-08-05: Distinct functions of BACE1 and BACE2 in neuregulin processing and melanocyte migration Alzheimer's & Dementia. 9: P144-P144. DOI: 10.1016/J.Jalz.2013.04.096  0.375
2012 Page RM, Münch A, Horn T, Kuhn PH, Colombo A, Reiner O, Boutros M, Steiner H, Lichtenthaler SF, Haass C. Loss of PAFAH1B2 reduces amyloid-β generation by promoting the degradation of amyloid precursor protein C-terminal fragments. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 18204-14. PMID 23238734 DOI: 10.1523/Jneurosci.2681-12.2012  0.442
2012 Voss M, Fukumori A, Kuhn PH, Künzel U, Klier B, Grammer G, Haug-Kröper M, Kremmer E, Lichtenthaler SF, Steiner H, Schröder B, Haass C, Fluhrer R. Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3). The Journal of Biological Chemistry. 287: 43401-9. PMID 23132852 DOI: 10.1074/Jbc.M112.371369  0.318
2012 Wils H, Kleinberger G, Pereson S, Janssens J, Capell A, Van Dam D, Cuijt I, Joris G, De Deyn PP, Haass C, Van Broeckhoven C, Kumar-Singh S. Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice. The Journal of Pathology. 228: 67-76. PMID 22733568 DOI: 10.1002/Path.4043  0.311
2012 Kuhn PH, Koroniak K, Hogl S, Colombo A, Zeitschel U, Willem M, Volbracht C, Schepers U, Imhof A, Hoffmeister A, Haass C, Roßner S, Bräse S, Lichtenthaler SF. Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons. The Embo Journal. 31: 3157-68. PMID 22728825 DOI: 10.1038/Emboj.2012.173  0.351
2012 Orozco D, Tahirovic S, Rentzsch K, Schwenk BM, Haass C, Edbauer D. Loss of fused in sarcoma (FUS) promotes pathological Tau splicing. Embo Reports. 13: 759-64. PMID 22710833 DOI: 10.1038/Embor.2012.90  0.652
2012 Bentmann E, Neumann M, Tahirovic S, Rodde R, Dormann D, Haass C. Requirements for stress granule recruitment of fused in sarcoma (FUS) and TAR DNA-binding protein of 43 kDa (TDP-43). The Journal of Biological Chemistry. 287: 23079-94. PMID 22563080 DOI: 10.1074/Jbc.M111.328757  0.314
2012 Haass C, Kaether C, Thinakaran G, Sisodia S. Trafficking and proteolytic processing of APP. Cold Spring Harbor Perspectives in Medicine. 2: a006270. PMID 22553493 DOI: 10.1101/Cshperspect.A006270  0.457
2012 Lang CM, Fellerer K, Schwenk BM, Kuhn PH, Kremmer E, Edbauer D, Capell A, Haass C. Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration. The Journal of Biological Chemistry. 287: 19355-65. PMID 22511793 DOI: 10.1074/Jbc.M112.365098  0.637
2012 Grundmann K, Glöckle N, Martella G, Sciamanna G, Hauser TK, Yu L, Castaneda S, Pichler B, Fehrenbacher B, Schaller M, Nuscher B, Haass C, Hettich J, Yue Z, Nguyen HP, et al. Generation of a novel rodent model for DYT1 dystonia. Neurobiology of Disease. 47: 61-74. PMID 22472189 DOI: 10.1016/J.Nbd.2012.03.024  0.32
2012 Fleck D, Garratt AN, Haass C, Willem M. BACE1 dependent neuregulin processing: review. Current Alzheimer Research. 9: 178-83. PMID 22455478 DOI: 10.2174/156720512799361637  0.377
2012 Leuner K, Schütt T, Kurz C, Eckert SH, Schiller C, Occhipinti A, Mai S, Jendrach M, Eckert GP, Kruse SE, Palmiter RD, Brandt U, Dröse S, Wittig I, Willem M, ... Haass C, et al. Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation. Antioxidants & Redox Signaling. 16: 1421-33. PMID 22229260 DOI: 10.1089/Ars.2011.4173  0.364
2012 Fluhrer R, Martin L, Klier B, Haug-Kröper M, Grammer G, Nuscher B, Haass C. The α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b). The Journal of Biological Chemistry. 287: 5156-63. PMID 22194595 DOI: 10.1074/Jbc.M111.328104  0.323
2012 Rominger A, Brendel M, Baumann K, Gildehaus F, Niedermoser S, Wängler B, Burgold S, Herms J, Cumming P, Steiner H, Haass C, Bartenstein P. Longitudinal imaging of cerebral beta-amyloid in APP-swe mice using [18F]florbetaben PET Alzheimers & Dementia. 8. DOI: 10.1016/J.Jalz.2012.05.411  0.571
2012 Lichtenthaler S, Dislich B, Hogl S, Colombo A, Zeitschel U, Willem M, Haass C, Volbracht C, Roßner S, Kuhn P. Therapeutic potential of BACE1/beta-secretase: Proteome-wide identification of physiological BACE1 substrates in primary neurons and mouse brain Alzheimers & Dementia. 8: 96. DOI: 10.1016/J.Jalz.2012.05.236  0.36
2012 Rominger A, Brendel M, Baumann K, Gildehaus F, Niedermoser S, Wängler B, Burgold S, Herms J, Cumming P, Steiner H, Haass C, Bartenstein P. Longitudinal imaging of cerebral Aβ in APP-Swe mice using [18F]florbetaben PET Alzheimers & Dementia. 8: 11. DOI: 10.1016/J.Jalz.2012.05.033  0.531
2011 Lammich S, Kamp F, Wagner J, Nuscher B, Zilow S, Ludwig AK, Willem M, Haass C. Translational repression of the disintegrin and metalloprotease ADAM10 by a stable G-quadruplex secondary structure in its 5'-untranslated region. The Journal of Biological Chemistry. 286: 45063-72. PMID 22065584 DOI: 10.1074/Jbc.M111.296921  0.34
2011 Ebke A, Luebbers T, Fukumori A, Shirotani K, Haass C, Baumann K, Steiner H. Novel γ-secretase enzyme modulators directly target presenilin protein. The Journal of Biological Chemistry. 286: 37181-6. PMID 21896486 DOI: 10.1074/Jbc.C111.276972  0.42
2011 Neumann M, Bentmann E, Dormann D, Jawaid A, DeJesus-Hernandez M, Ansorge O, Roeber S, Kretzschmar HA, Munoz DG, Kusaka H, Yokota O, Ang LC, Bilbao J, Rademakers R, Haass C, et al. FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations. Brain : a Journal of Neurology. 134: 2595-609. PMID 21856723 DOI: 10.1093/Brain/Awr201  0.375
2011 Fluhrer R, Kamp F, Grammer G, Nuscher B, Steiner H, Beyer K, Haass C. The Nicastrin ectodomain adopts a highly thermostable structure. Biological Chemistry. 392: 995-1001. PMID 21848507 DOI: 10.1515/Bc.2011.169  0.399
2011 Dormann D, Haass C. TDP-43 and FUS: a nuclear affair. Trends in Neurosciences. 34: 339-48. PMID 21700347 DOI: 10.1016/J.Tins.2011.05.002  0.34
2011 Lichtenthaler SF, Haass C, Steiner H. Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing. Journal of Neurochemistry. 117: 779-96. PMID 21413990 DOI: 10.1111/J.1471-4159.2011.07248.X  0.43
2011 Kretner B, Fukumori A, Gutsmiedl A, Page RM, Luebbers T, Galley G, Baumann K, Haass C, Steiner H. Attenuated Abeta42 responses to low potency gamma-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compounds. The Journal of Biological Chemistry. 286: 15240-51. PMID 21357415 DOI: 10.1074/Jbc.M110.213587  0.342
2011 Capell A, Liebscher S, Fellerer K, Brouwers N, Willem M, Lammich S, Gijselinck I, Bittner T, Carlson AM, Sasse F, Kunze B, Steinmetz H, Jansen R, Dormann D, Sleegers K, ... ... Haass C, et al. Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 1885-94. PMID 21289198 DOI: 10.1523/Jneurosci.5757-10.2011  0.334
2011 Rolyan H, Feike AC, Upadhaya AR, Waha A, Van Dooren T, Haass C, Birkenmeier G, Pietrzik CU, Van Leuven F, Thal DR. Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer's disease. Journal of Neural Transmission (Vienna, Austria : 1996). 118: 699-712. PMID 21210284 DOI: 10.1007/S00702-010-0572-7  0.387
2011 Upadhaya AR, Capetillo-Zarate E, Lungrin I, Abramowski D, Kumar S, Yamaguchi H, Haass C, Walter J, Staufenbiel M, Fändrich M, Thal D. P3-165: Elevated levels of soluble, high molecular weight SDS-denaturable Aβ-aggregates are associated with dendritic degeneration in APP-transgenic mouse models Alzheimer's & Dementia. 7: S569-S570. DOI: 10.1016/J.Jalz.2011.05.1605  0.343
2010 Förstl H, Haass C, Hemmer B, Meyer B, Halle M. Boxing-acute complications and late sequelae: from concussion to dementia. Deutsches ã„Rzteblatt International. 107: 835-9. PMID 21173899 DOI: 10.3238/Arztebl.2010.0835  0.389
2010 Bartels T, Ahlstrom LS, Leftin A, Kamp F, Haass C, Brown MF, Beyer K. The N-terminus of the intrinsically disordered protein α-synuclein triggers membrane binding and helix folding. Biophysical Journal. 99: 2116-24. PMID 20923645 DOI: 10.1016/J.Bpj.2010.06.035  0.728
2010 Kamp F, Exner N, Lutz AK, Wender N, Hegermann J, Brunner B, Nuscher B, Bartels T, Giese A, Beyer K, Eimer S, Winklhofer KF, Haass C. Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1. The Embo Journal. 29: 3571-89. PMID 20842103 DOI: 10.1038/Emboj.2010.223  0.712
2010 Haass C, Mandelkow E. Fyn-tau-amyloid: a toxic triad. Cell. 142: 356-8. PMID 20691893 DOI: 10.1016/J.Cell.2010.07.032  0.438
2010 Fett ME, Pilsl A, Paquet D, van Bebber F, Haass C, Tatzelt J, Schmid B, Winklhofer KF. Parkin is protective against proteotoxic stress in a transgenic zebrafish model. Plos One. 5: e11783. PMID 20689587 DOI: 10.1371/Journal.Pone.0011783  0.306
2010 Dormann D, Rodde R, Edbauer D, Bentmann E, Fischer I, Hruscha A, Than ME, Mackenzie IR, Capell A, Schmid B, Neumann M, Haass C. ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import. The Embo Journal. 29: 2841-57. PMID 20606625 DOI: 10.1038/Emboj.2010.143  0.624
2010 Mitterreiter S, Page RM, Kamp F, Hopson J, Winkler E, Ha HR, Hamid R, Herms J, Mayer TU, Nelson DJ, Steiner H, Stahl T, Zeitschel U, Rossner S, Haass C, et al. Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 8974-83. PMID 20592218 DOI: 10.1523/Jneurosci.1199-10.2010  0.416
2010 Dettmer U, Kuhn PH, Abou-Ajram C, Lichtenthaler SF, Krüger M, Kremmer E, Haass C, Haffner C. Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex. The Journal of Biological Chemistry. 285: 26174-81. PMID 20538592 DOI: 10.1074/Jbc.M110.132548  0.794
2010 Fukumori A, Fluhrer R, Steiner H, Haass C. Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 7853-62. PMID 20534834 DOI: 10.1523/Jneurosci.1443-10.2010  0.458
2010 van Bebber F, Paquet D, Hruscha A, Schmid B, Haass C. Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in zebrafish. Neurobiology of Disease. 39: 265-71. PMID 20381619 DOI: 10.1016/J.Nbd.2010.03.023  0.435
2010 Page RM, Gutsmiedl A, Fukumori A, Winkler E, Haass C, Steiner H. Beta-amyloid precursor protein mutants respond to gamma-secretase modulators. The Journal of Biological Chemistry. 285: 17798-810. PMID 20348104 DOI: 10.1074/Jbc.M110.103283  0.447
2010 Lammich S, Buell D, Zilow S, Ludwig AK, Nuscher B, Lichtenthaler SF, Prinzen C, Fahrenholz F, Haass C. Expression of the anti-amyloidogenic secretase ADAM10 is suppressed by its 5'-untranslated region. The Journal of Biological Chemistry. 285: 15753-60. PMID 20348102 DOI: 10.1074/Jbc.M110.110742  0.443
2010 Fuhrmann M, Bittner T, Jung CK, Burgold S, Page RM, Mitteregger G, Haass C, LaFerla FM, Kretzschmar H, Herms J. Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease. Nature Neuroscience. 13: 411-3. PMID 20305648 DOI: 10.1038/Nn.2511  0.353
2010 Paquet D, Schmid B, Haass C. Transgenic zebrafish as a novel animal model to study tauopathies and other neurodegenerative disorders in vivo. Neuro-Degenerative Diseases. 7: 99-102. PMID 20173336 DOI: 10.1159/000285515  0.354
2010 Pérez-Revuelta BI, Fukumori A, Lammich S, Yamasaki A, Haass C, Steiner H. Requirement for small side chain residues within the GxGD-motif of presenilin for gamma-secretase substrate cleavage. Journal of Neurochemistry. 112: 940-50. PMID 20021564 DOI: 10.1111/J.1471-4159.2009.06510.X  0.394
2010 Fassler M, Zocher M, Klare S, de la Fuente AG, Scheuermann J, Capell A, Haass C, Valkova C, Veerappan A, Schneider D, Kaether C. Masking of transmembrane-based retention signals controls ER export of gamma-secretase. Traffic (Copenhagen, Denmark). 11: 250-8. PMID 19958468 DOI: 10.1111/J.1600-0854.2009.01014.X  0.334
2010 Haass C, Rodde R, Edbauer D, Bentmann E, Fischer I, Hruscha A, Than M, Mackenzie I, Capell A, Schmid B, Neumann M, Dormann D. O4-03-06: Familial Als-associated Fused in Sarcoma (fus) Mutations Disrupt Transportin-mediated Nuclear Import Alzheimer's & Dementia. 6: e17-e17. DOI: 10.1016/J.Jalz.2010.08.051  0.58
2010 Haass C, Fukumori A, Steiner H. O2-03-02: Stepwise autoproteolysis of presenilin 1 is affected by familial Alzheimer's disease mutations Alzheimer's & Dementia. 6: S101-S101. DOI: 10.1016/J.Jalz.2010.05.315  0.322
2009 Yanagida K, Okochi M, Tagami S, Nakayama T, Kodama TS, Nishitomi K, Jiang J, Mori K, Tatsumi S, Arai T, Ikeuchi T, Kasuga K, Tokuda T, Kondo M, Ikeda M, ... ... Haass C, et al. The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system. Embo Molecular Medicine. 1: 223-35. PMID 20049724 DOI: 10.1002/Emmm.200900026  0.438
2009 Itoh N, Okochi M, Tagami S, Nishitomi K, Nakayama T, Yanagida K, Fukumori A, Jiang J, Mori K, Hosono M, Kikuchi J, Nakano Y, Takinami Y, Dohi K, Nishigaki A, ... ... Haass C, et al. Destruxin E decreases Beta-amyloid generation by reducing colocalization of beta-amyloid-cleaving enzyme 1 and beta-amyloid protein precursor. Neuro-Degenerative Diseases. 6: 230-9. PMID 19738368 DOI: 10.1159/000236902  0.441
2009 Bittner T, Fuhrmann M, Burgold S, Jung CK, Volbracht C, Steiner H, Mitteregger G, Kretzschmar HA, Haass C, Herms J. Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 10405-9. PMID 19692615 DOI: 10.1523/Jneurosci.2288-09.2009  0.428
2009 Fournier M, Vitte J, Garrigue J, Langui D, Dullin JP, Saurini F, Hanoun N, Perez-Diaz F, Cornilleau F, Joubert C, Ardila-Osorio H, Traver S, Duchateau R, Goujet-Zalc C, Paleologou K, ... ... Haass C, et al. Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy. Plos One. 4: e6629. PMID 19680561 DOI: 10.1371/Journal.Pone.0006629  0.313
2009 Dormann D, Capell A, Carlson AM, Shankaran SS, Rodde R, Neumann M, Kremmer E, Matsuwaki T, Yamanouchi K, Nishihara M, Haass C. Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin. Journal of Neurochemistry. 110: 1082-94. PMID 19522733 DOI: 10.1111/J.1471-4159.2009.06211.X  0.389
2009 Willem M, Lammich S, Haass C. Function, regulation and therapeutic properties of beta-secretase (BACE1). Seminars in Cell & Developmental Biology. 20: 175-82. PMID 19429494 DOI: 10.1016/J.Semcdb.2009.01.003  0.469
2009 Paquet D, Bhat R, Sydow A, Mandelkow EM, Berg S, Hellberg S, Fälting J, Distel M, Köster RW, Schmid B, Haass C. A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation. The Journal of Clinical Investigation. 119: 1382-95. PMID 19363289 DOI: 10.1172/Jci37537  0.366
2009 Fluhrer R, Steiner H, Haass C. Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases. The Journal of Biological Chemistry. 284: 13975-9. PMID 19189970 DOI: 10.1074/Jbc.R800040200  0.331
2009 Winkler E, Hobson S, Fukumori A, Dümpelfeld B, Luebbers T, Baumann K, Haass C, Hopf C, Steiner H. Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase. Biochemistry. 48: 1183-97. PMID 19159235 DOI: 10.1021/Bi801204G  0.456
2009 Martin L, Fluhrer R, Haass C. Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis. The Journal of Biological Chemistry. 284: 5662-70. PMID 19114711 DOI: 10.1074/Jbc.M807485200  0.338
2009 Jawaid A, Rademakers R, Kass JS, Kalkonde Y, Okochi M, Tagami S, Nishitomi K, Nef T, Quinter G, Isobe C, Abe T, Portelius E, Zhang B, Benetin J, Zerr I, ... ... Haass C, et al. Contents Vol. 6, 2009 Neurodegenerative Diseases. 6. DOI: 10.1159/000278750  0.309
2009 Jawaid A, Rademakers R, Kass JS, Kalkonde Y, Okochi M, Tagami S, Nishitomi K, Nef T, Quinter G, Isobe C, Abe T, Portelius E, Zhang B, Benetin J, Zerr I, ... ... Haass C, et al. Subject Index Vol. 6, 2009 Neurodegenerative Diseases. 6: 282-282. DOI: 10.1159/000278749  0.316
2009 Haass C. Alzheimer - Mechanismen und therapeutische Ansätze. Warum wir im Alter dement werden Biologie in Unserer Zeit. 39: 92-100. DOI: 10.1002/Biuz.200910388  0.35
2008 O'Connor T, Sadleir KR, Maus E, Velliquette RA, Zhao J, Cole SL, Eimer WA, Hitt B, Bembinster LA, Lammich S, Lichtenthaler SF, Hébert SS, De Strooper B, Haass C, Bennett DA, et al. Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron. 60: 988-1009. PMID 19109907 DOI: 10.1016/J.Neuron.2008.10.047  0.43
2008 Busche MA, Eichhoff G, Adelsberger H, Abramowski D, Wiederhold KH, Haass C, Staufenbiel M, Konnerth A, Garaschuk O. Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease. Science (New York, N.Y.). 321: 1686-9. PMID 18802001 DOI: 10.1126/Science.1162844  0.362
2008 Steiner H, Winkler E, Haass C. Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1. The Journal of Biological Chemistry. 283: 34677-86. PMID 18801744 DOI: 10.1074/Jbc.M709067200  0.397
2008 Fluhrer R, Fukumori A, Martin L, Grammer G, Haug-Kröper M, Klier B, Winkler E, Kremmer E, Condron MM, Teplow DB, Steiner H, Haass C. Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation. The Journal of Biological Chemistry. 283: 30121-8. PMID 18768471 DOI: 10.1074/Jbc.M806092200  0.43
2008 Steiner H, Fluhrer R, Haass C. Intramembrane proteolysis by gamma-secretase. The Journal of Biological Chemistry. 283: 29627-31. PMID 18650432 DOI: 10.1074/Jbc.R800010200  0.444
2008 Dejaegere T, Serneels L, Schäfer MK, Van Biervliet J, Horré K, Depboylu C, Alvarez-Fischer D, Herreman A, Willem M, Haass C, Höglinger GU, D'Hooge R, De Strooper B. Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment. Proceedings of the National Academy of Sciences of the United States of America. 105: 9775-80. PMID 18626010 DOI: 10.1073/Pnas.0800507105  0.338
2008 St George-Hyslop P, Haass C. Regulatory RNA goes awry in Alzheimer's disease. Nature Medicine. 14: 711-2. PMID 18607365 DOI: 10.1038/Nm0708-711  0.323
2008 Schöbel S, Neumann S, Hertweck M, Dislich B, Kuhn PH, Kremmer E, Seed B, Baumeister R, Haass C, Lichtenthaler SF. A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein. The Journal of Biological Chemistry. 283: 14257-68. PMID 18353773 DOI: 10.1074/Jbc.M801531200  0.422
2008 Winklhofer KF, Tatzelt J, Haass C. The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases. The Embo Journal. 27: 336-49. PMID 18216876 DOI: 10.1038/Sj.Emboj.7601930  0.392
2008 Shankaran SS, Capell A, Hruscha AT, Fellerer K, Neumann M, Schmid B, Haass C. Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion. The Journal of Biological Chemistry. 283: 1744-53. PMID 17984093 DOI: 10.1074/Jbc.M705115200  0.361
2008 Martin L, Fluhrer R, Reiss K, Kremmer E, Saftig P, Haass C. Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b. The Journal of Biological Chemistry. 283: 1644-52. PMID 17965014 DOI: 10.1074/Jbc.M706661200  0.358
2008 Page RM, Baumann K, Tomioka M, Pérez-Revuelta BI, Fukumori A, Jacobsen H, Flohr A, Luebbers T, Ozmen L, Steiner H, Haass C. Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation. The Journal of Biological Chemistry. 283: 677-83. PMID 17962197 DOI: 10.1074/Jbc.M708754200  0.437
2008 Haass C. S4-01-06: Mechanisms of intramembrane proteolysis by gamma-secretase and related proteases Alzheimer's & Dementia. 4: T178-T178. DOI: 10.1016/J.Jalz.2008.05.477  0.406
2008 Lichtenthaler SF, Mitterreiter S, Haass C. O1-04-01: Novel drugs simultaneously modulate both beta- and gamma-secretase cleavage of the amyloid precursor protein Alzheimer's & Dementia. 4: T114-T114. DOI: 10.1016/J.Jalz.2008.05.238  0.38
2008 Fluhrer R, Fukumori A, Martin L, Teplow DB, Steiner H, Haass C. P4-188: Intramembrane cleavage of TNFalpha by SPPL2b carrying a familial Alzheimer's disease-like mutation Alzheimer's & Dementia. 4: T726-T726. DOI: 10.1016/J.Jalz.2008.05.2255  0.344
2008 Lammich S, Zilow S, Büll D, Ludwig A, Prinzen C, Fahrenholz F, Jacquemin-Sablon H, Haass C. P3-335: Upstream of N-ras (UNR) is involved in translational control of ADAM10 protein expression Alzheimer's & Dementia. 4: T620-T620. DOI: 10.1016/J.Jalz.2008.05.1904  0.382
2007 Sato T, Diehl TS, Narayanan S, Funamoto S, Ihara Y, De Strooper B, Steiner H, Haass C, Wolfe MS. Active gamma-secretase complexes contain only one of each component. The Journal of Biological Chemistry. 282: 33985-93. PMID 17911105 DOI: 10.1074/Jbc.M705248200  0.426
2007 Hamid R, Kilger E, Willem M, Vassallo N, Kostka M, Bornhövd C, Reichert AS, Kretzschmar HA, Haass C, Herms J. Amyloid precursor protein intracellular domain modulates cellular calcium homeostasis and ATP content. Journal of Neurochemistry. 102: 1264-75. PMID 17763532 DOI: 10.1111/J.1471-4159.2007.04627.X  0.306
2007 Kaether C, Scheuermann J, Fassler M, Zilow S, Shirotani K, Valkova C, Novak B, Kacmar S, Steiner H, Haass C. Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1. Embo Reports. 8: 743-8. PMID 17668005 DOI: 10.1038/Sj.Embor.7401027  0.44
2007 Fluhrer R, Haass C. Signal peptide peptidases and gamma-secretase: cousins of the same protease family? Neuro-Degenerative Diseases. 4: 112-6. PMID 17596705 DOI: 10.1159/000101835  0.372
2007 Shirotani K, Tomioka M, Kremmer E, Haass C, Steiner H. Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes. Neurobiology of Disease. 27: 102-7. PMID 17560791 DOI: 10.1016/J.Nbd.2007.04.011  0.468
2007 Prager K, Wang-Eckhardt L, Fluhrer R, Killick R, Barth E, Hampel H, Haass C, Walter J. A structural switch of presenilin 1 by glycogen synthase kinase 3beta-mediated phosphorylation regulates the interaction with beta-catenin and its nuclear signaling. The Journal of Biological Chemistry. 282: 14083-93. PMID 17360711 DOI: 10.1074/Jbc.M608437200  0.396
2007 Görner K, Holtorf E, Waak J, Pham TT, Vogt-Weisenhorn DM, Wurst W, Haass C, Kahle PJ. Structural determinants of the C-terminal helix-kink-helix motif essential for protein stability and survival promoting activity of DJ-1. The Journal of Biological Chemistry. 282: 13680-91. PMID 17331951 DOI: 10.1074/Jbc.M609821200  0.334
2007 Kuhn PH, Marjaux E, Imhof A, De Strooper B, Haass C, Lichtenthaler SF. Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase. The Journal of Biological Chemistry. 282: 11982-95. PMID 17307738 DOI: 10.1074/Jbc.M700356200  0.308
2007 Haffner C, Dettmer U, Weiler T, Haass C. The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex. The Journal of Biological Chemistry. 282: 10632-8. PMID 17261586 DOI: 10.1074/Jbc.M611033200  0.8
2007 Haass C, Selkoe DJ. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nature Reviews. Molecular Cell Biology. 8: 101-12. PMID 17245412 DOI: 10.1038/Nrm2101  0.675
2007 Schiffer NW, Broadley SA, Hirschberger T, Tavan P, Kretzschmar HA, Giese A, Haass C, Hartl FU, Schmid B. Identification of anti-prion compounds as efficient inhibitors of polyglutamine protein aggregation in a zebrafish model. The Journal of Biological Chemistry. 282: 9195-203. PMID 17170113 DOI: 10.1074/Jbc.M607865200  0.365
2007 Narlawar R, Pérez Revuelta BI, Baumann K, Schubenel R, Haass C, Steiner H, Schmidt B. N-Substituted carbazolyloxyacetic acids modulate Alzheimer associated gamma-secretase. Bioorganic & Medicinal Chemistry Letters. 17: 176-82. PMID 17035010 DOI: 10.1016/J.Bmcl.2006.09.061  0.368
2007 Thal DR, Larionov S, Abramowski D, Wiederhold KH, Van Dooren T, Yamaguchi H, Haass C, Van Leuven F, Staufenbiel M, Capetillo-Zarate E. Occurrence and co-localization of amyloid beta-protein and apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice. Neurobiology of Aging. 28: 1221-30. PMID 16815595 DOI: 10.1016/J.Neurobiolaging.2006.05.029  0.401
2006 Narlawar R, Pérez Revuelta BI, Haass C, Steiner H, Schmidt B, Baumann K. Scaffold of the cyclooxygenase-2 (COX-2) inhibitor carprofen provides Alzheimer gamma-secretase modulators. Journal of Medicinal Chemistry. 49: 7588-91. PMID 17181139 DOI: 10.1021/Jm0610200  0.358
2006 Haffner C, Haass C. Cellular functions of gamma-secretase-related proteins. Neuro-Degenerative Diseases. 3: 284-9. PMID 17047369 DOI: 10.1159/000095268  0.422
2006 Kaether C, Haass C, Steiner H. Assembly, trafficking and function of gamma-secretase. Neuro-Degenerative Diseases. 3: 275-83. PMID 17047368 DOI: 10.1159/000095267  0.445
2006 Willem M, Garratt AN, Novak B, Citron M, Kaufmann S, Rittger A, DeStrooper B, Saftig P, Birchmeier C, Haass C. Control of peripheral nerve myelination by the beta-secretase BACE1. Science (New York, N.Y.). 314: 664-6. PMID 16990514 DOI: 10.1126/Science.1132341  0.34
2006 Radde R, Bolmont T, Kaeser SA, Coomaraswamy J, Lindau D, Stoltze L, Calhoun ME, Jäggi F, Wolburg H, Gengler S, Haass C, Ghetti B, Czech C, Hölscher C, Mathews PM, et al. Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. Embo Reports. 7: 940-6. PMID 16906128 DOI: 10.1038/Sj.Embor.7400784  0.418
2006 Steiner H, Than M, Bode W, Haass C. Pore-forming scissors? A first structural glimpse of gamma-secretase. Trends in Biochemical Sciences. 31: 491-3. PMID 16890442 DOI: 10.1016/J.Tibs.2006.07.008  0.472
2006 Capetillo-Zarate E, Staufenbiel M, Abramowski D, Haass C, Escher A, Stadelmann C, Yamaguchi H, Wiestler OD, Thal DR. Selective vulnerability of different types of commissural neurons for amyloid beta-protein-induced neurodegeneration in APP23 mice correlates with dendritic tree morphology. Brain : a Journal of Neurology. 129: 2992-3005. PMID 16844716 DOI: 10.1093/Brain/Awl176  0.387
2006 Fluhrer R, Grammer G, Israel L, Condron MM, Haffner C, Friedmann E, Böhland C, Imhof A, Martoglio B, Teplow DB, Haass C. A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b. Nature Cell Biology. 8: 894-6. PMID 16829951 DOI: 10.1038/Ncb1450  0.343
2006 Goldsbury C, Mocanu MM, Thies E, Kaether C, Haass C, Keller P, Biernat J, Mandelkow E, Mandelkow EM. Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides. Traffic (Copenhagen, Denmark). 7: 873-88. PMID 16734669 DOI: 10.1111/J.1600-0854.2006.00434.X  0.424
2006 Anders L, Mertins P, Lammich S, Murgia M, Hartmann D, Saftig P, Haass C, Ullrich A. Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activity. Molecular and Cellular Biology. 26: 3917-34. PMID 16648485 DOI: 10.1128/Mcb.26.10.3917-3934.2006  0.391
2006 Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, et al. Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct. Biochemistry. 45: 4907-14. PMID 16605258 DOI: 10.1021/Bi052412W  0.408
2006 Yamasaki A, Eimer S, Okochi M, Smialowska A, Kaether C, Baumeister R, Haass C, Steiner H. The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 3821-8. PMID 16597736 DOI: 10.1523/Jneurosci.5354-05.2006  0.393
2006 Kaether C, Schmitt S, Willem M, Haass C. Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface. Traffic (Copenhagen, Denmark). 7: 408-15. PMID 16536739 DOI: 10.1111/J.1600-0854.2006.00396.X  0.438
2006 Böhm C, Seibel NM, Henkel B, Steiner H, Haass C, Hampe W. SorLA signaling by regulated intramembrane proteolysis. The Journal of Biological Chemistry. 281: 14547-53. PMID 16531402 DOI: 10.1074/Jbc.M601660200  0.345
2006 Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M. Secretion of the Notch-1 Abeta-like peptide during Notch signaling. The Journal of Biological Chemistry. 281: 7890-8. PMID 16434391 DOI: 10.1074/Jbc.M513250200  0.411
2006 Neumann S, Schöbel S, Jäger S, Trautwein A, Haass C, Pietrzik CU, Lichtenthaler SF. Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein. The Journal of Biological Chemistry. 281: 7583-94. PMID 16344553 DOI: 10.1074/Jbc.M508340200  0.479
2006 Haass C, Multhaup G. Six years of collaborative Alzheimer's disease research in Germany Neurodegenerative Diseases. 3: 193-196. DOI: 10.1159/000095256  0.322
2006 Capell A, Wild-Bode C, Haass C. P2-045: A novel basolateral sorting signal directs α-secretase (ADAM10) to adherens junctions and limits amyloid generation Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.882  0.307
2006 Thal DR, Larionov S, Abramowski D, Wiederhold K, Yamaguchi H, Haass C, Staufenbiel M, Capetillo-Zarate E. P1-029: Occurrence of amyloid β-protein and co-localization with apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice Alzheimer's & Dementia. 2: S102-S103. DOI: 10.1016/J.Jalz.2006.05.404  0.33
2006 Neumann S, Schöbel S, Jäger S, Haass C, Pietrzik CU, Lichtenthaler SF. P4-070: Amyloid precursor-like proteins 1 and 2 influence proteolytic processing of the amyloid precursor protein by alpha- and beta-secretase Alzheimer's & Dementia. 2: S534-S534. DOI: 10.1016/J.Jalz.2006.05.1808  0.424
2006 Schöbel S, Neumann S, Haass C, Lichtenthaler SF. P4-058: Sorting nexin 31 is a novel activator of the alpha-cleavage of the amyloid precursor protein Alzheimer's & Dementia. 2: S530-S530. DOI: 10.1016/J.Jalz.2006.05.1796  0.346
2006 Fischer SV, Haass C, Lichtenthaler SF. P4-003: A novel protein interacts with APP and modifies APP secretion Alzheimer's & Dementia. 2: S514-S514. DOI: 10.1016/J.Jalz.2006.05.1741  0.336
2006 Ikuta A, Tagami S, Jiang J, Yanagida K, Nakayama T, Ishizuka-Katsura Y, Mori K, Tao H, Morihara T, Kamino K, Tanaka T, Kudo T, Steiner H, Haass C, Okochi M, et al. P3-253: Aβ generation and degradation by BACE1 Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.1522  0.324
2006 Lichtenthaler SF, Schöbel S, Neumann S, Fischer S, Haass C. O2-03-01: Novel proteins act as gatekeepers and control access of APP to alpha- and beta-secretase Alzheimer's & Dementia. 2: S34-S35. DOI: 10.1016/J.Jalz.2006.05.120  0.336
2005 Thal DR, Capetillo-Zarate E, Schultz C, Rüb U, Saido TC, Yamaguchi H, Haass C, Griffin WS, Del Tredici K, Braak H, Ghebremedhin E. Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner. Acta Neuropathologica. 110: 459-71. PMID 16195918 DOI: 10.1007/S00401-005-1053-1  0.433
2005 Krawitz P, Haffner C, Fluhrer R, Steiner H, Schmid B, Haass C. Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3. The Journal of Biological Chemistry. 280: 39515-23. PMID 15998642 DOI: 10.1074/Jbc.M501645200  0.375
2005 Giese A, Bader B, Bieschke J, Schaffar G, Odoy S, Kahle PJ, Haass C, Kretzschmar H. Single particle detection and characterization of synuclein co-aggregation. Biochemical and Biophysical Research Communications. 333: 1202-10. PMID 15978545 DOI: 10.1016/J.Bbrc.2005.06.025  0.365
2005 Prokop S, Haass C, Steiner H. Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments. Journal of Neurochemistry. 94: 57-62. PMID 15953349 DOI: 10.1111/J.1471-4159.2005.03165.X  0.665
2005 Wahle T, Prager K, Raffler N, Haass C, Famulok M, Walter J. GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network. Molecular and Cellular Neurosciences. 29: 453-61. PMID 15886016 DOI: 10.1016/J.Mcn.2005.03.014  0.353
2005 Uelhoff A, Tatzelt J, Aguzzi A, Winklhofer KF, Haass C. A pathogenic PrP mutation and doppel interfere with polarized sorting of the prion protein. The Journal of Biological Chemistry. 280: 5137-40. PMID 15615717 DOI: 10.1074/Jbc.C400560200  0.569
2005 Capell A, Beher D, Prokop S, Steiner H, Kaether C, Shearman MS, Haass C. Gamma-secretase complex assembly within the early secretory pathway. The Journal of Biological Chemistry. 280: 6471-8. PMID 15591316 DOI: 10.1074/jbc.M409106200  0.662
2005 Yamamoto A, Friedlein A, Imai Y, Takahashi R, Kahle PJ, Haass C. Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity. The Journal of Biological Chemistry. 280: 3390-9. PMID 15557340 DOI: 10.1074/Jbc.M407724200  0.324
2004 Haffner C, Haass C. The biochemical and genetic odyssey to the function of a nicastrin-like protein. Neuro-Degenerative Diseases. 1: 192-5. PMID 16908989 DOI: 10.1159/000080985  0.384
2004 Kaether C, Haass C. A lipid boundary separates APP and secretases and limits amyloid beta-peptide generation. The Journal of Cell Biology. 167: 809-12. PMID 15583026 DOI: 10.1083/Jcb.200410090  0.398
2004 Kaether C, Capell A, Edbauer D, Winkler E, Novak B, Steiner H, Haass C. The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity. The Embo Journal. 23: 4738-48. PMID 15549135 DOI: 10.1038/Sj.Emboj.7600478  0.65
2004 Willem M, Dewachter I, Smyth N, Van Dooren T, Borghgraef P, Haass C, Van Leuven F. beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice. The American Journal of Pathology. 165: 1621-31. PMID 15509532 DOI: 10.1016/S0002-9440(10)63419-0  0.441
2004 Westmeyer GG, Willem M, Lichtenthaler SF, Lurman G, Multhaup G, Assfalg-Machleidt I, Reiss K, Saftig P, Haass C. Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme. The Journal of Biological Chemistry. 279: 53205-12. PMID 15485862 DOI: 10.1074/Jbc.M410378200  0.761
2004 Keil U, Bonert A, Marques CA, Scherping I, Weyermann J, Strosznajder JB, Müller-Spahn F, Haass C, Czech C, Pradier L, Müller WE, Eckert A. Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis. The Journal of Biological Chemistry. 279: 50310-20. PMID 15371443 DOI: 10.1074/Jbc.M405600200  0.422
2004 Shirotani K, Edbauer D, Prokop S, Haass C, Steiner H. Identification of distinct gamma-secretase complexes with different APH-1 variants. The Journal of Biological Chemistry. 279: 41340-5. PMID 15286082 DOI: 10.1074/Jbc.M405768200  0.752
2004 Haffner C, Frauli M, Topp S, Irmler M, Hofmann K, Regula JT, Bally-Cuif L, Haass C. Nicalin and its binding partner Nomo are novel Nodal signaling antagonists. The Embo Journal. 23: 3041-50. PMID 15257293 DOI: 10.1038/Sj.Emboj.7600307  0.33
2004 Schmechel A, Strauss M, Schlicksupp A, Pipkorn R, Haass C, Bayer TA, Multhaup G. Human BACE forms dimers and colocalizes with APP. The Journal of Biological Chemistry. 279: 39710-7. PMID 15247262 DOI: 10.1074/Jbc.M402785200  0.414
2004 Kahle PJ, Haass C. How does parkin ligate ubiquitin to Parkinson's disease? Embo Reports. 5: 681-5. PMID 15229644 DOI: 10.1038/Sj.Embor.7400188  0.373
2004 Edbauer D, Kaether C, Steiner H, Haass C. Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1. The Journal of Biological Chemistry. 279: 37311-5. PMID 15210705 DOI: 10.1074/Jbc.M406228200  0.664
2004 Shirotani K, Edbauer D, Kostka M, Steiner H, Haass C. Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1. Journal of Neurochemistry. 89: 1520-7. PMID 15189355 DOI: 10.1111/J.1471-4159.2004.02447.X  0.702
2004 Lammich S, Schöbel S, Zimmer AK, Lichtenthaler SF, Haass C. Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region. Embo Reports. 5: 620-5. PMID 15167888 DOI: 10.1038/Sj.Embor.7400166  0.36
2004 Lichtenthaler SF, Haass C. Amyloid at the cutting edge: activation of alpha-secretase prevents amyloidogenesis in an Alzheimer disease mouse model. The Journal of Clinical Investigation. 113: 1384-7. PMID 15146234 DOI: 10.1172/Jci21746  0.399
2004 Prokop S, Shirotani K, Edbauer D, Haass C, Steiner H. Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex. The Journal of Biological Chemistry. 279: 23255-61. PMID 15039426 DOI: 10.1074/Jbc.M401789200  0.771
2004 Neumann M, Müller V, Görner K, Kretzschmar HA, Haass C, Kahle PJ. Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease. Acta Neuropathologica. 107: 489-96. PMID 14991385 DOI: 10.1007/S00401-004-0834-2  0.343
2004 Haass C. Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation. The Embo Journal. 23: 483-8. PMID 14749724 DOI: 10.1038/Sj.Emboj.7600061  0.399
2004 Görner K, Holtorf E, Odoy S, Nuscher B, Yamamoto A, Regula JT, Beyer K, Haass C, Kahle PJ. Differential effects of Parkinson's disease-associated mutations on stability and folding of DJ-1. The Journal of Biological Chemistry. 279: 6943-51. PMID 14607841 DOI: 10.1074/Jbc.M309204200  0.327
2004 Fluhrer R, Friedlein A, Haass C, Walter J. Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis. The Journal of Biological Chemistry. 279: 1585-93. PMID 14576165 DOI: 10.1074/Jbc.M306653200  0.328
2004 Eckert A, Keil U, Bonert A, Scherping I, Marques CA, Haass C, Czech C, Pradier L, Müller WE. P4-252 Impact of β-amyloid on mitochondrial failure in Alzheimer's disease Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81810-4  0.345
2004 Lichtenthaler SF, Schöbel S, Neumann S, Seed B, Haass C. P4-198 Genome-wide screen identifies proteins stimulating the alpha- and beta-secretase cleavage of AFP Neurobiology of Aging. 25: S531. DOI: 10.1016/S0197-4580(04)81756-1  0.311
2004 Steiner H, Prokop S, Shirotani K, Edbauer D, Winkler E, Haass C. P4-192 Structure-function analysis of the gamma-secretase complex subunit PEN-2 Neurobiology of Aging. 25: S530. DOI: 10.1016/S0197-4580(04)81750-0  0.726
2004 Hamid R, Willem M, Edbauer D, Steiner H, Müller U, Wünsch G, Kretzschmar H, Haass C, Herms J. O4-04-06 β-Amyloid precursor protein intracellular domain (AICD) strongly enhances resting free cytosolic calcium levels Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80277-X  0.607
2004 Walter J, Prager K, Diallo M, Wahle T, Lütjohann D, Haass C, Sandhoff K, Schepers U, Tamboli I. O2-03-08 Glycosphingolipids regulate subcellular transport of the β-amyloid procursor protein and the generation of amyloid β-peptide Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80126-X  0.325
2003 Capell A, Kaether C, Edbauer D, Shirotani K, Merkl S, Steiner H, Haass C. Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain. The Journal of Biological Chemistry. 278: 52519-23. PMID 14602727 DOI: 10.1074/Jbc.C300435200  0.667
2003 Aguzzi A, Haass C. Games played by rogue proteins in prion disorders and Alzheimer's disease. Science (New York, N.Y.). 302: 814-8. PMID 14593165 DOI: 10.1126/Science.1087348  0.581
2003 Lichtenthaler SF, Dominguez DI, Westmeyer GG, Reiss K, Haass C, Saftig P, De Strooper B, Seed B. The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1. The Journal of Biological Chemistry. 278: 48713-9. PMID 14507929 DOI: 10.1074/Jbc.M303861200  0.732
2003 Marques CA, Keil U, Bonert A, Steiner B, Haass C, Muller WE, Eckert A. Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway. The Journal of Biological Chemistry. 278: 28294-302. PMID 12730216 DOI: 10.1074/Jbc.M212265200  0.369
2003 Sato T, Dohmae N, Qi Y, Kakuda N, Misonou H, Mitsumori R, Maruyama H, Koo EH, Haass C, Takio K, Morishima-Kawashima M, Ishiura S, Ihara Y. Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein. The Journal of Biological Chemistry. 278: 24294-301. PMID 12707272 DOI: 10.1074/Jbc.M211161200  0.646
2003 Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C. Reconstitution of gamma-secretase activity. Nature Cell Biology. 5: 486-8. PMID 12679784 DOI: 10.1038/Ncb960  0.701
2003 Shirotani K, Edbauer D, Capell A, Schmitz J, Steiner H, Haass C. Gamma-secretase activity is associated with a conformational change of nicastrin. The Journal of Biological Chemistry. 278: 16474-7. PMID 12644462 DOI: 10.1074/Jbc.C300095200  0.668
2003 Ehehalt R, Keller P, Haass C, Thiele C, Simons K. Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts. The Journal of Cell Biology. 160: 113-23. PMID 12515826 DOI: 10.1083/Jcb.200207113  0.427
2003 Fluhrer R, Multhaup G, Schlicksupp A, Okochi M, Takeda M, Lammich S, Willem M, Westmeyer G, Bode W, Walter J, Haass C. Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation. The Journal of Biological Chemistry. 278: 5531-8. PMID 12471021 DOI: 10.1074/Jbc.M211485200  0.721
2003 Steiner H, Edbauer D, Shirotani K, Haass C. S.03.03 Characterization and reconstitution of gamma-secretase European Neuropsychopharmacology. 13: S101. DOI: 10.1016/S0924-977X(03)91607-5  0.567
2002 Haass C, Steiner H. Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases. Trends in Cell Biology. 12: 556-62. PMID 12495843 DOI: 10.1016/S0962-8924(02)02394-2  0.38
2002 Neumann M, Kahle PJ, Giasson BI, Ozmen L, Borroni E, Spooren W, Müller V, Odoy S, Fujiwara H, Hasegawa M, Iwatsubo T, Trojanowski JQ, Kretzschmar HA, Haass C. Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies. The Journal of Clinical Investigation. 110: 1429-39. PMID 12438441 DOI: 10.1172/Jci15777  0.393
2002 Okochi M, Steiner H, Fukumori A, Tanii H, Tomita T, Tanaka T, Iwatsubo T, Kudo T, Takeda M, Haass C. Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1. The Embo Journal. 21: 5408-16. PMID 12374741 DOI: 10.1093/Emboj/Cdf541  0.468
2002 Lammich S, Okochi M, Takeda M, Kaether C, Capell A, Zimmer AK, Edbauer D, Walter J, Steiner H, Haass C. Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide. The Journal of Biological Chemistry. 277: 44754-9. PMID 12223485 DOI: 10.1074/Jbc.M206872200  0.697
2002 Steiner H, Winkler E, Edbauer D, Prokop S, Basset G, Yamasaki A, Kostka M, Haass C. PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin. The Journal of Biological Chemistry. 277: 39062-5. PMID 12198112 DOI: 10.1074/Jbc.C200469200  0.758
2002 Kaether C, Lammich S, Edbauer D, Ertl M, Rietdorf J, Capell A, Steiner H, Haass C. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane. The Journal of Cell Biology. 158: 551-61. PMID 12147673 DOI: 10.1083/Jcb.200201123  0.675
2002 Geling A, Steiner H, Willem M, Bally-Cuif L, Haass C. A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish. Embo Reports. 3: 688-94. PMID 12101103 DOI: 10.1093/Embo-Reports/Kvf124  0.411
2002 Fluhrer R, Capell A, Westmeyer G, Willem M, Hartung B, Condron MM, Teplow DB, Haass C, Walter J. A non-amyloidogenic function of BACE-2 in the secretory pathway. Journal of Neurochemistry. 81: 1011-20. PMID 12065613 DOI: 10.1046/J.1471-4159.2002.00908.X  0.757
2002 Leutz S, Steiner B, Marques CA, Haass C, Müller WE, Eckert A. Reduction of trophic support enhances apoptosis in PC12 cells expressing Alzheimer's APP mutation and sensitizes cells to staurosporine-induced cell death. Journal of Molecular Neuroscience : Mn. 18: 189-201. PMID 12059037 DOI: 10.1385/Jmn:18:3:189  0.335
2002 Edbauer D, Winkler E, Haass C, Steiner H. Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation. Proceedings of the National Academy of Sciences of the United States of America. 99: 8666-71. PMID 12048259 DOI: 10.1073/Pnas.132277899  0.698
2002 Moehlmann T, Winkler E, Xia X, Edbauer D, Murrell J, Capell A, Kaether C, Zheng H, Ghetti B, Haass C, Steiner H. Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production. Proceedings of the National Academy of Sciences of the United States of America. 99: 8025-30. PMID 12048239 DOI: 10.1073/Pnas.112686799  0.698
2002 Edbauer D, Willem M, Lammich S, Steiner H, Haass C. Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD). The Journal of Biological Chemistry. 277: 13389-93. PMID 11809755 DOI: 10.1074/Jbc.M111571200  0.678
2002 Capell A, Meyn L, Fluhrer R, Teplow DB, Walter J, Haass C. Apical sorting of beta-secretase limits amyloid beta-peptide production. The Journal of Biological Chemistry. 277: 5637-43. PMID 11741885 DOI: 10.1074/Jbc.M109119200  0.437
2002 Walter J, Haass C. Secretases as targets for beta-amyloid lowering drugs Drug Development Research. 56: 201-210. DOI: 10.1002/Ddr.10076  0.438
2001 Kahle PJ, Haass C. The emerging utility of animal models of chronic neurodegenerative diseases. Expert Opinion On Therapeutic Targets. 5: 125-32. PMID 15992171 DOI: 10.1517/14728222.5.1.125  0.397
2001 Steiner H, Haass C. Nuclear signaling: a common function of presenilin substrates? Journal of Molecular Neuroscience : Mn. 17: 193-8. PMID 11816792 DOI: 10.1385/JMN:17:2:193  0.382
2001 Kahle PJ, Neumann M, Ozmen L, Müller V, Odoy S, Okamoto N, Jacobsen H, Iwatsubo T, Trojanowski JQ, Takahashi H, Wakabayashi K, Bogdanovic N, Riederer P, Kretzschmar HA, Haass C. Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model. The American Journal of Pathology. 159: 2215-25. PMID 11733371 DOI: 10.1016/S0002-9440(10)63072-6  0.452
2001 Walter J, Kaether C, Steiner H, Haass C. The cell biology of Alzheimer's disease: uncovering the secrets of secretases. Current Opinion in Neurobiology. 11: 585-90. PMID 11595492 DOI: 10.1016/S0959-4388(00)00253-1  0.472
2001 Haass C, Steiner H. Protofibrils, the unifying toxic molecule of neurodegenerative disorders? Nature Neuroscience. 4: 859-60. PMID 11528409 DOI: 10.1038/Nn0901-859  0.385
2001 Sastre M, Steiner H, Fuchs K, Capell A, Multhaup G, Condron MM, Teplow DB, Haass C. Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch. Embo Reports. 2: 835-41. PMID 11520861 DOI: 10.1093/Embo-Reports/Kve180  0.467
2001 Steiner H, Winkler E, Shearman MS, Prywes R, Haass C. Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins. Neurobiology of Disease. 8: 717-22. PMID 11493036 DOI: 10.1006/Nbdi.2001.0405  0.469
2001 Rathke-Hartlieb S, Kahle PJ, Neumann M, Ozmen L, Haid S, Okochi M, Haass C, Schulz JB. Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice. Journal of Neurochemistry. 77: 1181-4. PMID 11359883 DOI: 10.1046/J.1471-4159.2001.00366.X  0.315
2001 Eckert A, Steiner B, Marques C, Leutz S, Romig H, Haass C, Müller WE. Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation. Journal of Neuroscience Research. 64: 183-92. PMID 11288146 DOI: 10.1002/Jnr.1064  0.329
2001 Walter J, Fluhrer R, Hartung B, Willem M, Kaether C, Capell A, Lammich S, Multhaup G, Haass C. Phosphorylation regulates intracellular trafficking of beta-secretase. The Journal of Biological Chemistry. 276: 14634-41. PMID 11278841 DOI: 10.1074/Jbc.M011116200  0.42
2001 Yamazaki T, Chang TY, Haass C, Ihara Y. Accumulation and aggregation of amyloid beta-protein in late endosomes of Niemann-pick type C cells. The Journal of Biological Chemistry. 276: 4454-60. PMID 11085995 DOI: 10.1074/Jbc.M009598200  0.423
2001 Steiner H, Revesz T, Neumann M, Romig H, Grim MG, Pesold B, Kretzschmar HA, Hardy J, Holton JL, Baumeister R, Houlden H, Haass C. A pathogenic presenilin-1 deletion causes abberrant Abeta 42 production in the absence of congophilic amyloid plaques. The Journal of Biological Chemistry. 276: 7233-9. PMID 11084029 DOI: 10.1074/Jbc.M007183200  0.476
2000 Walter J, Haass C. Posttranslational modifications of amyloid precursor protein : ectodomain phosphorylation and sulfation. Methods in Molecular Medicine. 32: 149-68. PMID 21318517 DOI: 10.1385/1-59259-195-7:149  0.389
2000 Yu G, Chen F, Nishimura M, Steiner H, Tandon A, Kawarai T, Arawaka S, Supala A, Song YQ, Rogaeva E, Holmes E, Zhang DM, Milman P, Fraser P, Haass C, et al. Mutation of conserved aspartates affect maturation of presenilin 1 and presenilin 2 complexes. Acta Neurologica Scandinavica. Supplementum. 176: 6-11. PMID 11261807 DOI: 10.1034/J.1600-0404.2000.00301.X  0.317
2000 Steiner H, Haass C. Intramembrane proteolysis by presenilins. Nature Reviews. Molecular Cell Biology. 1: 217-24. PMID 11252897 DOI: 10.1038/35043065  0.45
2000 Kahle PJ, Neumann M, Ozmen L, Haass C. Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein. Annals of the New York Academy of Sciences. 920: 33-41. PMID 11193173 DOI: 10.1111/J.1749-6632.2000.Tb06902.X  0.333
2000 Mathews PM, Cataldo AM, Kao BH, Rudnicki AG, Qin X, Yang JL, Jiang Y, Picciano M, Hulette C, Lippa CF, Bird TD, Nochlin D, Walter J, Haass C, Lévesque L, et al. Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease. Molecular Medicine (Cambridge, Mass.). 6: 878-91. PMID 11126202 DOI: 10.1007/Bf03401825  0.373
2000 Wirths O, Weickert S, Majtenyi K, Havas L, Kahle PJ, Okochi M, Haass C, Multhaup G, Beyreuther K, Bayer TA. Lewy body variant of Alzheimer's disease: alpha-synuclein in dystrophic neurites of A beta plaques. Neuroreport. 11: 3737-41. PMID 11117482 DOI: 10.1097/00001756-200011270-00029  0.421
2000 Steiner H, Kostka M, Romig H, Basset G, Pesold B, Hardy J, Capell A, Meyn L, Grim ML, Baumeister R, Fechteler K, Haass C. Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases. Nature Cell Biology. 2: 848-51. PMID 11056541 DOI: 10.1038/35041097  0.413
2000 Okochi M, Eimer S, Bottcher A, Baumeister R, Romig H, Walter J, Capell A, Steiner H, Haass C. A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells. The Journal of Biological Chemistry. 275: 40925-32. PMID 11013240 DOI: 10.1074/Jbc.M005254200  0.41
2000 Kahle PJ, Neumann M, Ozmen L, Muller V, Jacobsen H, Schindzielorz A, Okochi M, Leimer U, van Der Putten H, Probst A, Kremmer E, Kretzschmar HA, Haass C. Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 6365-73. PMID 10964942 DOI: 10.1523/Jneurosci.20-17-06365.2000  0.337
2000 Yu G, Chen F, Nishimura M, Steiner H, Tandon A, Kawarai T, Arawaka S, Supala A, Song YQ, Rogaeva E, Holmes E, Zhang DM, Milman P, Fraser PE, Haass C, et al. Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes. The Journal of Biological Chemistry. 275: 27348-53. PMID 10856299 DOI: 10.1074/Jbc.M002982200  0.363
2000 Kulic L, Walter J, Multhaup G, Teplow DB, Baumeister R, Romig H, Capell A, Steiner H, Haass C. Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch. Proceedings of the National Academy of Sciences of the United States of America. 97: 5913-8. PMID 10811883 DOI: 10.1073/Pnas.100049897  0.448
2000 Walter J, Schindzielorz A, Hartung B, Haass C. Phosphorylation of the beta-amyloid precursor protein at the cell surface by ectocasein kinases 1 and 2. The Journal of Biological Chemistry. 275: 23523-9. PMID 10806211 DOI: 10.1074/Jbc.M002850200  0.308
2000 Capell A, Steiner H, Willem M, Kaiser H, Meyer C, Walter J, Lammich S, Multhaup G, Haass C. Maturation and pro-peptide cleavage of beta-secretase. The Journal of Biological Chemistry. 275: 30849-54. PMID 10801872 DOI: 10.1074/Jbc.M003202200  0.402
2000 Capell A, Steiner H, Romig H, Keck S, Baader M, Grim MG, Baumeister R, Haass C. Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch. Nature Cell Biology. 2: 205-11. PMID 10783238 DOI: 10.1038/35008626  0.47
2000 Haass C, Kahle PJ. Parkinson's pathology in a fly. Nature. 404: 341, 343. PMID 10746706 DOI: 10.1038/35006188  0.302
2000 Hayashi H, Mizuno T, Michikawa M, Haass C, Yanagisawa K. Amyloid precursor protein in unique cholesterol-rich microdomains different from caveolae-like domains. Biochimica Et Biophysica Acta. 1483: 81-90. PMID 10601697 DOI: 10.1016/S1388-1981(99)00174-2  0.334
2000 Haass C, Kulic L, Capell A, Steiner H, Multhaup G, Teplow D, Romig H. Separation of presenilin function in amyloid β-peptide generation and endoproteolysis of Notch Neurobiology of Aging. 21: 141. DOI: 10.1016/S0197-4580(00)82432-X  0.315
1999 Haass C, Baumeister R. The biological and pathological function of presenilin proteins--simple cell systems and a worm in Alzheimer's disease research. European Archives of Psychiatry and Clinical Neuroscience. 249: 23-7. PMID 10654096 DOI: 10.1007/Pl00014169  0.421
1999 Steiner H, Capell A, Leimer U, Haass C. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease. European Archives of Psychiatry and Clinical Neuroscience. 249: 266-70. PMID 10653281 DOI: 10.1007/S004060050098  0.485
1999 Haass C. Biology of Alzheimer's disease. European Archives of Psychiatry and Clinical Neuroscience. 249: 265. PMID 10653280 DOI: 10.1007/S004060050097  0.351
1999 Steiner H, Pesold B, Haass C. An in vivo assay for the identification of target proteases which cleave membrane-associated substrates. Febs Letters. 463: 245-9. PMID 10606730 DOI: 10.1016/S0014-5793(99)01627-0  0.428
1999 Steiner H, Romig H, Pesold B, Philipp U, Baader M, Citron M, Loetscher H, Jacobsen H, Haass C. Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis. Biochemistry. 38: 14600-5. PMID 10545183 DOI: 10.1021/Bi9914210  0.445
1999 Haass C, De Strooper B. The presenilins in Alzheimer's disease--proteolysis holds the key. Science (New York, N.Y.). 286: 916-9. PMID 10542139 DOI: 10.1126/Science.286.5441.916  0.483
1999 Leimer U, Lun K, Romig H, Walter J, Grünberg J, Brand M, Haass C. Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis. Biochemistry. 38: 13602-9. PMID 10521267 DOI: 10.1021/Bi991453N  0.49
1999 Steiner H, Duff K, Capell A, Romig H, Grim MG, Lincoln S, Hardy J, Yu X, Picciano M, Fechteler K, Citron M, Kopan R, Pesold B, Keck S, Baader M, ... ... Haass C, et al. A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling. The Journal of Biological Chemistry. 274: 28669-73. PMID 10497236 DOI: 10.1074/Jbc.274.40.28669  0.471
1999 Guénette SY, Chen J, Ferland A, Haass C, Capell A, Tanzi RE. hFE65L influences amyloid precursor protein maturation and secretion. Journal of Neurochemistry. 73: 985-93. PMID 10461887 DOI: 10.1046/J.1471-4159.1999.0730985.X  0.443
1999 Haass C, Mandelkow E. Proteolysis by presenilins and the renaissance of tau. Trends in Cell Biology. 9: 241-4. PMID 10408925 DOI: 10.1016/S0962-8924(99)01576-7  0.416
1999 Haass C. Apoptosis. Dead end for neurodegeneration? Nature. 399: 204-5, 207. PMID 10353238 DOI: 10.1038/20314  0.439
1999 Diehlmann A, Ida N, Weggen S, Grünberg J, Haass C, Masters CL, Bayer TA, Beyreuther K. Analysis of presenilin 1 and presenilin 2 expression and processing by newly developed monoclonal antibodies. Journal of Neuroscience Research. 56: 405-19. PMID 10340748 DOI: 10.1002/(Sici)1097-4547(19990515)56:4<405::Aid-Jnr8>3.0.Co;2-F  0.422
1999 Mizuno T, Nakata M, Naiki H, Michikawa M, Wang R, Haass C, Yanagisawa K. Cholesterol-dependent generation of a seeding amyloid beta-protein in cell culture. The Journal of Biological Chemistry. 274: 15110-4. PMID 10329717 DOI: 10.1074/Jbc.274.21.15110  0.441
1999 Lammich S, Kojro E, Postina R, Gilbert S, Pfeiffer R, Jasionowski M, Haass C, Fahrenholz F. Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. Proceedings of the National Academy of Sciences of the United States of America. 96: 3922-7. PMID 10097139 DOI: 10.1073/Pnas.96.7.3922  0.449
1999 Steiner H, Capell A, Haass C. Proteolytic processing and degradation of Alzheimer's disease relevant proteins. Biochemical Society Transactions. 27: 234-42. PMID 10093740 DOI: 10.1042/Bst0270234  0.384
1999 Steiner H, Romig H, Grim MG, Philipp U, Pesold B, Citron M, Baumeister R, Haass C. The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing. The Journal of Biological Chemistry. 274: 7615-8. PMID 10075646 DOI: 10.1074/Jbc.274.12.7615  0.449
1999 Thal DR, Sassin I, Schultz C, Haass C, Braak E, Braak H. Fleecy amyloid deposits in the internal layers of the human entorhinal cortex are comprised of N-terminal truncated fragments of Abeta. Journal of Neuropathology and Experimental Neurology. 58: 210-6. PMID 10029103 DOI: 10.1097/00005072-199902000-00010  0.423
1999 Walter J, Schindzielorz A, Grünberg J, Haass C. Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 96: 1391-6. PMID 9990034 DOI: 10.1073/Pnas.96.4.1391  0.36
1999 Steiner H, Haass C. Proteolytic processing of β-amyloid precursor protein and presenilins Biochemical Society Transactions. 27: A23-A23. DOI: 10.1042/Bst027A023C  0.346
1998 Haass C, Baumeister R. What do we learn from a few familial Alzheimer's disease cases? Journal of Neural Transmission. Supplementum. 54: 137-45. PMID 9850922 DOI: 10.1007/978-3-7091-7508-8_13  0.418
1998 Grünberg J, Walter J, Eckman C, Capell A, Schindzielorz A, Younkin S, Mehta N, Hardy J, Haass C. Truncated presenilin 2 derived from differentially spliced mRNA does not affect the ratio of amyloid beta-peptide 1-42/1-40. Neuroreport. 9: 3293-9. PMID 9831466 DOI: 10.1097/00001756-199810050-00027  0.458
1998 Steiner H, Capell A, Pesold B, Citron M, Kloetzel PM, Selkoe DJ, Romig H, Mendla K, Haass C. Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation. The Journal of Biological Chemistry. 273: 32322-31. PMID 9822712 DOI: 10.1074/Jbc.273.48.32322  0.682
1998 Mizuno T, Haass C, Michikawa M, Yanagisawa K. Cholesterol-dependent generation of a unique amyloid beta-protein from apically missorted amyloid precursor protein in MDCK cells. Biochimica Et Biophysica Acta. 1373: 119-30. PMID 9733943 DOI: 10.1016/S0005-2736(98)00097-2  0.419
1998 Haass C, Grünberg J, Capell A, Wild-Bode C, Leimer U, Walter J, Yamazaki T, Ihara I, Zweckbronner I, Jakubek C, Baumeister R. Proteolytic processing of Alzheimer's disease associated proteins. Journal of Neural Transmission. Supplementum. 53: 159-67. PMID 9700654 DOI: 10.1007/978-3-7091-6467-9_14  0.458
1998 Oyama F, Sawamura N, Kobayashi K, Morishima-Kawashima M, Kuramochi T, Ito M, Tomita T, Maruyama K, Saido TC, Iwatsubo T, Capell A, Walter J, Grünberg J, Ueyama Y, Haass C, et al. Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain. Journal of Neurochemistry. 71: 313-22. PMID 9648880 DOI: 10.1046/J.1471-4159.1998.71010313.X  0.409
1998 Brockhaus M, Grünberg J, Röhrig S, Loetscher H, Wittenburg N, Baumeister R, Jacobsen H, Haass C. Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling. Neuroreport. 9: 1481-6. PMID 9631452 DOI: 10.1097/00001756-199805110-00043  0.392
1998 Walter J, Grünberg J, Schindzielorz A, Haass C. Proteolytic fragments of the Alzheimer's disease associated presenilins-1 and -2 are phosphorylated in vivo by distinct cellular mechanisms. Biochemistry. 37: 5961-7. PMID 9558331 DOI: 10.1021/Bi971763A  0.327
1998 Grunberg J, Walter J, Loetscher H, Deuschle U, Jacobsen H, Haass C. Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family. Biochemistry. 37: 2263-70. PMID 9485372 DOI: 10.1021/Bi972106L  0.372
1998 Capell A, Grünberg J, Pesold B, Diehlmann A, Citron M, Nixon R, Beyreuther K, Selkoe DJ, Haass C. The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex. The Journal of Biological Chemistry. 273: 3205-11. PMID 9452432 DOI: 10.1074/Jbc.273.6.3205  0.608
1998 Haass C, Selkoe DJ. Alzheimer's disease. A technical KO of amyloid-beta peptide. Nature. 391: 339-40. PMID 9450743 DOI: 10.1038/34800  0.68
1997 Capell A, Saffrich R, Olivo JC, Meyn L, Walter J, Grünberg J, Mathews P, Nixon R, Dotti C, Haass C. Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation. Journal of Neurochemistry. 69: 2432-40. PMID 9375676 DOI: 10.1046/J.1471-4159.1997.69062432.X  0.354
1997 Kim SH, Kim YK, Jeong SJ, Haass C, Kim YH, Suh YH. Enhanced release of secreted form of Alzheimer's amyloid precursor protein from PC12 cells by nicotine. Molecular Pharmacology. 52: 430-6. PMID 9281605 DOI: 10.1124/Mol.52.3.430  0.353
1997 Loetscher H, Deuschle U, Brockhaus M, Reinhardt D, Nelboeck P, Mous J, Grünberg J, Haass C, Jacobsen H. Presenilins are processed by caspase-type proteases. The Journal of Biological Chemistry. 272: 20655-9. PMID 9252383 DOI: 10.1074/Jbc.272.33.20655  0.341
1997 Yamazaki T, Haass C, Saido TC, Omura S, Ihara Y. Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition. Biochemistry. 36: 8377-83. PMID 9204885 DOI: 10.1021/Bi970209Y  0.44
1997 Haass C. Presenilins: genes for life and death. Neuron. 18: 687-90. PMID 9182794 DOI: 10.1016/S0896-6273(00)80309-8  0.38
1997 Podlisny MB, Citron M, Amarante P, Sherrington R, Xia W, Zhang J, Diehl T, Levesque G, Fraser P, Haass C, Koo EH, Seubert P, St George-Hyslop P, Teplow DB, Selkoe DJ. Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue. Neurobiology of Disease. 3: 325-37. PMID 9173929 DOI: 10.1006/Nbdi.1997.0129  0.733
1997 Walter J, Grünberg J, Capell A, Pesold B, Schindzielorz A, Citron M, Mendla K, George-Hyslop PS, Multhaup G, Selkoe DJ, Haass C. Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C. Proceedings of the National Academy of Sciences of the United States of America. 94: 5349-54. PMID 9144240 DOI: 10.1073/Pnas.94.10.5349  0.61
1997 Xia W, Zhang J, Kholodenko D, Citron M, Podlisny MB, Teplow DB, Haass C, Seubert P, Koo EH, Selkoe DJ. Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins. The Journal of Biological Chemistry. 272: 7977-82. PMID 9065468 DOI: 10.1074/Jbc.272.12.7977  0.753
1997 Tomita T, Maruyama K, Saido TC, Kume H, Shinozaki K, Tokuhiro S, Capell A, Walter J, Grünberg J, Haass C, Iwatsubo T, Obata K. The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue. Proceedings of the National Academy of Sciences of the United States of America. 94: 2025-30. PMID 9050898 DOI: 10.1073/Pnas.94.5.2025  0.455
1997 Walter J, Capell A, Hung AY, Langen H, Schnölzer M, Thinakaran G, Sisodia SS, Selkoe DJ, Haass C. Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations. The Journal of Biological Chemistry. 272: 1896-903. PMID 8999878 DOI: 10.1074/Jbc.272.3.1896  0.621
1996 Walter J, Capell A, Grünberg J, Pesold B, Schindzielorz A, Prior R, Podlisny MB, Fraser P, Hyslop PS, Selkoe DJ, Haass C. The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum. Molecular Medicine (Cambridge, Mass.). 2: 673-91. PMID 8972483 DOI: 10.1007/Bf03401652  0.679
1996 Haass C. Presenile because of presenilin: the presenilin genes and early onset Alzheimer's disease. Current Opinion in Neurology. 9: 254-9. PMID 8858181 DOI: 10.1097/00019052-199608000-00002  0.426
1996 Citron M, Diehl TS, Capell A, Haass C, Teplow DB, Selkoe DJ. Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF. Neuron. 17: 171-9. PMID 8755488 DOI: 10.1016/S0896-6273(00)80290-1  0.634
1996 Haass C. The molecular significance of amyloid beta-peptide for Alzheimer's disease. European Archives of Psychiatry and Clinical Neuroscience. 246: 118-23. PMID 8739395 DOI: 10.1007/Bf02189111  0.446
1996 Qiu WQ, Borth W, Ye Z, Haass C, Teplow DB, Selkoe DJ. Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex. The Journal of Biological Chemistry. 271: 8443-51. PMID 8626544 DOI: 10.1074/Jbc.271.14.8443  0.682
1996 Selkoe DJ, Yamazaki T, Citron M, Podlisny MB, Koo EH, Teplow DB, Haass C. The role of APP processing and trafficking pathways in the formation of amyloid beta-protein. Annals of the New York Academy of Sciences. 777: 57-64. PMID 8624127 DOI: 10.1111/J.1749-6632.1996.Tb34401.X  0.723
1996 Capell A, Teplow DB, Citron M, Selkoe DJ, Haass C. Substitution of phenylalanine by proline at position 19 of amyloid β peptide results in an increased production of amyloid β peptides with alternative N-termini after protein kinase C stimulation Amyloid. 3: 150-155. DOI: 10.3109/13506129609045514  0.631
1996 Haass C. All about alzheimer's disease: A report on the 25th annual meeting of the society for neuroscience, San Diego, November 11–16, 1995 Amyloid. 3: 59-63. DOI: 10.3109/13506129609014356  0.308
1996 Citron M, Xia W, Diehl T, Podlisny M, Sherrington R, Haass C, Seubert P, Hyslop P, Selkoe D. 320 Effect of presenilin mutations on BAPP processing in presenilin transfected cells Neurobiology of Aging. 17: S81. DOI: 10.1016/S0197-4580(96)80322-8  0.56
1996 Haass C, Walter J, Grünberg J, George-Hyslop PS, Selkoe D, Pesold B, Capell A. 150 Expression of the Presenilin proteins PS-1 and PS-2 in tissue culture cells Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80152-7  0.567
1995 Haass C, Capell A, Citron M, Teplow DB, Selkoe DJ. The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein. The Journal of Biological Chemistry. 270: 6186-92. PMID 7890753 DOI: 10.1074/Jbc.270.11.6186  0.64
1995 Haass C, Koo EH, Capell A, Teplow DB, Selkoe DJ. Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals. The Journal of Cell Biology. 128: 537-47. PMID 7860629 DOI: 10.1083/Jcb.128.4.537  0.723
1995 Lemere CA, Munger JS, Shi GP, Natkin L, Haass C, Chapman HA, Selkoe DJ. The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study. The American Journal of Pathology. 146: 848-60. PMID 7717452  0.595
1995 Munger JS, Haass C, Lemere CA, Shi GP, Wong WS, Teplow DB, Selkoe DJ, Chapman HA. Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S. The Biochemical Journal. 311: 299-305. PMID 7575468 DOI: 10.1042/Bj3110299  0.649
1995 Haass C, Lemere CA, Capell A, Citron M, Seubert P, Schenk D, Lannfelt L, Selkoe DJ. The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway. Nature Medicine. 1: 1291-6. PMID 7489411 DOI: 10.1038/Nm1295-1291  0.635
1994 Haass C, Koo EH, Teplow DB, Selkoe DJ. Polarized secretion of beta-amyloid precursor protein and amyloid beta-peptide in MDCK cells. Proceedings of the National Academy of Sciences of the United States of America. 91: 1564-8. PMID 8108445 DOI: 10.1073/Pnas.91.4.1564  0.726
1994 Haass C, Hung AY, Selkoe DJ, Teplow DB. Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor. The Journal of Biological Chemistry. 269: 17741-8. PMID 8021287  0.625
1994 Lo AC, Haass C, Wagner SL, Teplow DB, Sisodia SS. Metabolism of the "Swedish" amyloid precursor protein variant in Madin-Darby canine kidney cells. The Journal of Biological Chemistry. 269: 30966-73. PMID 7983032  0.333
1993 Haass C, Hung AY, Schlossmacher MG, Teplow DB, Selkoe DJ. beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms. The Journal of Biological Chemistry. 268: 3021-4. PMID 8428976  0.599
1993 Citron M, Haass C, Selkoe DJ. Production of amyloid-beta-peptide by cultured cells: no evidence for internal initiation of translation at Met596. Neurobiology of Aging. 14: 571-3. PMID 8295660 DOI: 10.1016/0197-4580(93)90041-9  0.64
1993 Haass C, Selkoe DJ. Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide. Cell. 75: 1039-42. PMID 8261505 DOI: 10.1016/0092-8674(93)90312-E  0.671
1993 Haass C, Hung AY, Schlossmacher MG, Oltersdorf T, Teplow DB, Selkoe DJ. Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules. Annals of the New York Academy of Sciences. 695: 109-16. PMID 8239267 DOI: 10.1111/J.1749-6632.1993.Tb23037.X  0.641
1993 Hung AY, Haass C, Nitsch RM, Qiu WQ, Citron M, Wurtman RJ, Growdon JH, Selkoe DJ. Activation of protein kinase C inhibits cellular production of the amyloid beta-protein. The Journal of Biological Chemistry. 268: 22959-62. PMID 8226807  0.623
1992 Schlossmacher MG, Ostaszewski BL, Hecker LI, Celi A, Haass C, Chin D, Lieberburg I, Furie BC, Furie B, Selkoe DJ. Detection of distinct isoform patterns of the beta-amyloid precursor protein in human platelets and lymphocytes. Neurobiology of Aging. 13: 421-34. PMID 1625772 DOI: 10.1016/0197-4580(92)90117-G  0.647
1992 Haass C, Koo EH, Mellon A, Hung AY, Selkoe DJ. Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature. 357: 500-3. PMID 1608449 DOI: 10.1038/357500A0  0.732
1992 Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, Seubert P, Vigo-Pelfrey C, Lieberburg I, Selkoe DJ. Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. Nature. 360: 672-4. PMID 1465129 DOI: 10.1038/360672A0  0.663
1992 Hung AY, Koo EH, Haass C, Selkoe DJ. Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage. Proceedings of the National Academy of Sciences of the United States of America. 89: 9439-43. PMID 1409654 DOI: 10.1073/Pnas.89.20.9439  0.726
1992 Haass C, Schlossmacher MG, Hung AY, Vigo-Pelfrey C, Mellon A, Ostaszewski BL, Lieberburg I, Koo EH, Schenk D, Teplow DB. Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature. 359: 322-5. PMID 1383826 DOI: 10.1038/359322A0  0.618
1991 Haass C, Hung AY, Selkoe DJ. Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 11: 3783-93. PMID 1744690 DOI: 10.1523/Jneurosci.11-12-03783.1991  0.647
1991 Haass C, Hung A, Selkoe D. Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion The Journal of Neuroscience. 11: 3783-3793. DOI: 10.1523/JNEUROSCI.11-12-03783.1991  0.604
1989 Haass C, Kloetzel PM. The Drosophila proteasome undergoes changes in its subunit pattern during development. Experimental Cell Research. 180: 243-52. PMID 2491814 DOI: 10.1016/0014-4827(89)90228-0  0.3
1989 Haass C, Pesold-Hurt B, Multhaup G, Beyreuther K, Kloetzel P. The PROS-35 gene encodes the 35 kd protein subunit of Drosophila melanogaster proteasome. The Embo Journal. 8: 2373-2379. DOI: 10.1002/J.1460-2075.1989.Tb08366.X  0.318
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