| Year |
Citation |
Score |
| 2020 |
Andreano KJ, Wardell SE, Baker JG, Desautels TK, Baldi R, Chao CA, Heetderks KA, Bae Y, Xiong R, Tonetti DA, Gutgesell LM, Zhao J, Sorrentino JA, Thompson DA, Bisi JE, ... ... Thatcher GRJ, et al. G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer. Breast Cancer Research and Treatment. PMID 32130619 DOI: 10.1007/S10549-020-05575-9 |
0.302 |
|
| 2020 |
O'Regan R, Hurley R, Sachdev J, Bleeker J, Tonetti D, Thatcher G, Venuti R, Dudek A. Abstract P5-11-06: Phase 1 study of TTC-352 in patients with metastatic breast cancer progressing on endocrine therapy Cancer Research. 80. DOI: 10.1158/1538-7445.Sabcs19-P5-11-06 |
0.324 |
|
| 2019 |
ORegan RM, Hurley R, Sachdev JC, Bleeker J, Tonetti D, Thatcher G, Venuti R, Dudek AZ. Abstract CT051: Phase I study of TTC-352 in patients with estrogen receptor-positive metastatic breast cancer Cancer Research. 79. DOI: 10.1158/1538-7445.Am2019-Ct051 |
0.311 |
|
| 2019 |
Xiong R, Li Y, Zhao J, Tonetti D, Thatcher G. Abstract 3830: Novel bromodomains and extra-terminal motif (BET) inhibitors developed against estrogen receptor positive, fulvestrant- and CDK4/6-resistant breast cancer models Cancer Research. 79: 3830-3830. DOI: 10.1158/1538-7445.Am2019-3830 |
0.406 |
|
| 2018 |
Gaisina IN, Lee SH, Kaidery NA, Ben Aissa M, Ahuja M, Smirnova NN, Wakade S, Gaisin A, Bourassa MW, Ratan RR, Nikulin SV, Poloznikov AA, Thomas B, Thatcher GRJ, Gazaryan IG. Activation of Nrf2 and Hypoxic Adaptive Response Contribute to Neuroprotection Elicited by Phenylhydroxamic Acid Selective HDAC6 Inhibitors. Acs Chemical Neuroscience. PMID 29338172 DOI: 10.1021/Acschemneuro.7B00435 |
0.3 |
|
| 2017 |
Petukhov PA, Abdelkarim H, Neelarapu R, Madriaga A, Kastrati I, Wang YT, Vaidya AS, Taha TY, Thatcher GRJ, Frasor J. Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Amine-based Histone Deacetylase Inhibitors. Chemmedchem. PMID 29080240 DOI: 10.1002/Cmdc.201700449 |
0.685 |
|
| 2017 |
Kastrati I, Siklos MI, Brovkovych SD, Thatcher GR, Frasor J. A Novel Strategy to Co-target Estrogen Receptor and Nuclear Factor κB Pathways with Hybrid Drugs for Breast Cancer Therapy. Hormones & Cancer. PMID 28396978 DOI: 10.1007/S12672-017-0294-5 |
0.73 |
|
| 2017 |
Kastrati I, Delgado-Rivera L, Georgieva G, Thatcher GR, Frasor J. Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells. Journal of Visualized Experiments : Jove. PMID 28190074 DOI: 10.3791/54798 |
0.733 |
|
| 2016 |
Pierce EN, Piyankarage SC, Dunlap TL, Litosh VA, Siklos MI, Wang YT, Thatcher GR. Prodrugs Bioactivated to Quinones Target NF-κB and Multiple Protein Networks: Identification of the Quinonome. Chemical Research in Toxicology. PMID 27258437 DOI: 10.1021/Acs.Chemrestox.6B00115 |
0.306 |
|
| 2016 |
Kastrati I, Siklos MI, Calderon-Gierszal EL, El-Shennawy L, Georgieva G, Thayer EN, Thatcher GR, Frasor J. Dimethyl Fumarate Inhibits the Nuclear Factor κB Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein. The Journal of Biological Chemistry. 291: 3639-47. PMID 26683377 DOI: 10.1074/Jbc.M115.679704 |
0.742 |
|
| 2016 |
Xiong R, Zhao J, Gutgesell L, Tonetti D, Thatcher G. Abstract 3902: Novel selective estrogen receptor downregulators developed using endocrine-independent breast cancer cell lines Cancer Research. 76: 3902-3902. DOI: 10.1158/1538-7445.Am2016-3902 |
0.392 |
|
| 2015 |
Kastrati I, Litosh VA, Zhao S, Alvarez M, Thatcher GR, Frasor J. A novel aspirin prodrug inhibits NFκB activity and breast cancer stem cell properties. Bmc Cancer. 15: 845. PMID 26530254 DOI: 10.1186/S12885-015-1868-7 |
0.733 |
|
| 2015 |
Fà M, Zhang H, Staniszewski A, Saeed F, Shen LW, Schiefer IT, Siklos MI, Tapadar S, Litosh VA, Libien J, Petukhov PA, Teich AF, Thatcher GR, Arancio O. Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 26484927 DOI: 10.3233/Jad-150618 |
0.693 |
|
| 2015 |
Kastrati I, Siklos M, Litosh V, Thatcher G, Frasor J. Abstract 4497: Design and synthesis of hybrid drugs to target inflammatory pathways in breast cancer Cancer Research. 75: 4497-4497. DOI: 10.1158/1538-7445.Am2015-4497 |
0.751 |
|
| 2014 |
Patel HK, Siklos MI, Abdelkarim H, Mendonca EL, Vaidya A, Petukhov PA, Thatcher GR. A chimeric SERM-histone deacetylase inhibitor approach to breast cancer therapy. Chemmedchem. 9: 602-13. PMID 23956109 DOI: 10.1002/Cmdc.201300270 |
0.301 |
|
| 2013 |
Schiefer IT, Tapadar S, Litosh V, Siklos M, Scism R, Wijewickrama GT, Chandrasena EP, Sinha V, Tavassoli E, Brunsteiner M, Fa' M, Arancio O, Petukhov P, Thatcher GR. Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors. Journal of Medicinal Chemistry. 56: 6054-68. PMID 23834438 DOI: 10.1021/Jm4006719 |
0.702 |
|
| 2013 |
Siklos MI, Gandhi RP, Xiong R, Schiefer IT, Litosh V, VandeVrede L, Thatcher GR. Discovery of neuroprotective soluble guanylate cyclase modulators (GCMs) aciting via NO/GC/cGMP/CREB pathway Bmc Pharmacology and Toxicology. 14. DOI: 10.1186/2050-6511-14-S1-P65 |
0.71 |
|
| 2012 |
Dunlap T, Piyankarage SC, Wijewickrama GT, Abdul-Hay S, Vanni M, Litosh V, Luo J, Thatcher GR. Quinone-induced activation of Keap1/Nrf2 signaling by aspirin prodrugs masquerading as nitric oxide. Chemical Research in Toxicology. 25: 2725-36. PMID 23035985 DOI: 10.1021/Tx3003609 |
0.744 |
|
| 2012 |
Schiefer IT, VandeVrede L, Fa' M, Arancio O, Thatcher GR. Furoxans (1,2,5-oxadiazole-N-oxides) as novel NO mimetic neuroprotective and procognitive agents. Journal of Medicinal Chemistry. 55: 3076-87. PMID 22429006 DOI: 10.1021/Jm201504S |
0.712 |
|
| 2012 |
Hemachandra LPMP, Choi J, Bolotn J, Thatcher G. Abstract LB-64: Selective estrogen receptor modulators (SERMs) act as breast cancer chemopreventive agents by attenuating oxidative estrogen metabolism Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-64 |
0.408 |
|
| 2011 |
Kastrati I, Edirisinghe PD, Hemachandra LP, Chandrasena ER, Choi J, Wang YT, Bolton JL, Thatcher GR. Raloxifene and desmethylarzoxifene block estrogen-induced malignant transformation of human breast epithelial cells. Plos One. 6: e27876. PMID 22140478 DOI: 10.1371/Journal.Pone.0027876 |
0.704 |
|
| 2011 |
Abdul-Hay S, Schiefer IT, Chandrasena RE, Li M, Abdelhamid R, Wang YT, Tavassoli E, Michalsen B, Asghodom RT, Luo J, Thatcher GR. NO-SSRIs: Nitric Oxide Chimera Drugs Incorporating a Selective Serotonin Reuptake Inhibitor. Acs Medicinal Chemistry Letters. 2: 656-661. PMID 21927645 DOI: 10.1021/Ml2000033 |
0.77 |
|
| 2011 |
Abdelhamid R, Luo J, Vandevrede L, Kundu I, Michalsen B, Litosh VA, Schiefer IT, Gherezghiher T, Yao P, Qin Z, Thatcher GR. Benzothiophene Selective Estrogen Receptor Modulators Provide Neuroprotection by a novel GPR30-dependent Mechanism. Acs Chemical Neuroscience. 2: 256-268. PMID 21731800 DOI: 10.1021/Cn100106A |
0.732 |
|
| 2011 |
Schiefer IT, Abdul-Hay S, Wang H, Vanni M, Qin Z, Thatcher GR. Inhibition of amyloidogenesis by nonsteroidal anti-inflammatory drugs and their hybrid nitrates. Journal of Medicinal Chemistry. 54: 2293-306. PMID 21405086 DOI: 10.1021/Jm101450P |
0.785 |
|
| 2010 |
Kastrati I, Edirisinghe PD, Wijewickrama GT, Thatcher GR. Estrogen-induced apoptosis of breast epithelial cells is blocked by NO/cGMP and mediated by extranuclear estrogen receptors. Endocrinology. 151: 5602-16. PMID 20943808 DOI: 10.1210/En.2010-0378 |
0.703 |
|
| 2010 |
Peng KW, Chang M, Wang YT, Wang Z, Qin Z, Bolton JL, Thatcher GR. Unexpected hormonal activity of a catechol equine estrogen metabolite reveals reversible glutathione conjugation. Chemical Research in Toxicology. 23: 1374-83. PMID 20540524 DOI: 10.1021/Tx100129H |
0.314 |
|
| 2010 |
Sinha V, Wijewickrama GT, Chandrasena RE, Xu H, Edirisinghe PD, Schiefer IT, Thatcher GR. Proteomic and mass spectroscopic quantitation of protein S-nitrosation differentiates NO-donors. Acs Chemical Biology. 5: 667-80. PMID 20524644 DOI: 10.1021/Cb100054M |
0.67 |
|
| 2010 |
Anand S, Schiefer IT, Thatcher GRJ. Nitric oxide donor and mimetic molecules in cancer chemotherapy and chemoprevention Forum On Immunopathological Diseases and Therapeutics. 1: 251-279. DOI: 10.1615/Forumimmundisther.V1.I4.20 |
0.684 |
|
| 2009 |
Abdul-Hay SO, Edirisinghe P, Thatcher GR. Selective modulation of amyloid-beta peptide degradation by flurbiprofen, fenofibrate, and related compounds regulates Abeta levels. Journal of Neurochemistry. 111: 683-95. PMID 19702658 DOI: 10.1111/j.1471-4159.2009.06355.x |
0.698 |
|
| 2009 |
Abdul-Hay SO, Luo J, Ashghodom RT, Thatcher GR. NO-flurbiprofen reduces amyloid-beta, is neuroprotective in cell culture, and enhances cognition in response to cholinergic blockade. Journal of Neurochemistry. 111: 766-76. PMID 19702655 DOI: 10.1111/j.1471-4159.2009.06353.x |
0.742 |
|
| 2009 |
Chirapu SR, Pachaiyappan B, Nural HF, Cheng X, Yuan H, Lankin DC, Abdul-Hay SO, Thatcher GR, Shen Y, Kozikowski AP, Petukhov PA. Molecular modeling, synthesis, and activity studies of novel biaryl and fused-ring BACE1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 264-74. PMID 19013792 DOI: 10.1016/J.Bmcl.2008.10.096 |
0.721 |
|
| 2009 |
Qin Z, Kastrati I, Ashgodom RT, Lantvit DD, Overk CR, Choi Y, van Breemen RB, Bolton JL, Thatcher GR. Structural modulation of oxidative metabolism in design of improved benzothiophene selective estrogen receptor modulators. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 161-9. PMID 18936111 DOI: 10.1124/Dmd.108.023408 |
0.692 |
|
| 2009 |
Molloy M, Thatcher G, Bolton J, Tonetti D. 2-(4-Hydroxyphenyl)-Benzo[b]thiophen-6-ol, an Estrogen-Like Compound, Induces Apoptosis in T47D/PKCα Breast Cancer Cells. Cancer Research. 69: 5140-5140. DOI: 10.1158/0008-5472.Sabcs-09-5140 |
0.399 |
|
| 2008 |
Hagos GK, Abdul-Hay SO, Sohn J, Edirisinghe PD, Chandrasena RE, Wang Z, Li Q, Thatcher GR. Anti-inflammatory, antiproliferative, and cytoprotective activity of NO chimera nitrates of use in cancer chemoprevention. Molecular Pharmacology. 74: 1381-91. PMID 18676677 DOI: 10.1124/Mol.108.046664 |
0.771 |
|
| 2008 |
Chang M, Overk CR, Kastrati I, Peng KW, Yao P, Qin ZH, Petukhov P, Bolton JL, Thatcher GR. Estrogenic activity of the equine estrogen metabolite, 4-methoxyequilenin. Advances in Experimental Medicine and Biology. 617: 601-7. PMID 18497087 DOI: 10.1007/978-0-387-69080-3_62 |
0.696 |
|
| 2008 |
Dunlap T, Abdul-Hay SO, Chandrasena RE, Hagos GK, Sinha V, Wang Z, Wang H, Thatcher GR. Nitrates and NO-NSAIDs in cancer chemoprevention and therapy: in vitro evidence querying the NO donor functionality. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 19: 115-24. PMID 18485921 DOI: 10.1016/J.Niox.2008.04.013 |
0.776 |
|
| 2007 |
Dunlap T, Chandrasena RE, Wang Z, Sinha V, Wang Z, Thatcher GR. Quinone formation as a chemoprevention strategy for hybrid drugs: balancing cytotoxicity and cytoprotection. Chemical Research in Toxicology. 20: 1903-12. PMID 17975886 DOI: 10.1021/Tx7002257 |
0.345 |
|
| 2007 |
Yu B, Dietz BM, Dunlap T, Kastrati I, Lantvit DD, Overk CR, Yao P, Qin Z, Bolton JL, Thatcher GR. Structural modulation of reactivity/activity in design of improved benzothiophene selective estrogen receptor modulators: induction of chemopreventive mechanisms. Molecular Cancer Therapeutics. 6: 2418-28. PMID 17876041 DOI: 10.1158/1535-7163.Mct-07-0268 |
0.737 |
|
| 2007 |
Hagos GK, Carroll RE, Kouznetsova T, Li Q, Toader V, Fernandez PA, Swanson SM, Thatcher GR. Colon cancer chemoprevention by a novel NO chimera that shows anti-inflammatory and antiproliferative activity in vitro and in vivo. Molecular Cancer Therapeutics. 6: 2230-9. PMID 17699720 DOI: 10.1158/1535-7163.Mct-07-0069 |
0.798 |
|
| 2007 |
Overk CR, Peng KW, Asghodom RT, Kastrati I, Lantvit DD, Qin Z, Frasor J, Bolton JL, Thatcher GR. Structure-activity relationships for a family of benzothiophene selective estrogen receptor modulators including raloxifene and arzoxifene. Chemmedchem. 2: 1520-6. PMID 17654759 DOI: 10.1002/Cmdc.200700104 |
0.711 |
|
| 2007 |
Chang M, Peng KW, Kastrati I, Overk CR, Qin ZH, Yao P, Bolton JL, Thatcher GR. Activation of estrogen receptor-mediated gene transcription by the equine estrogen metabolite, 4-methoxyequilenin, in human breast cancer cells. Endocrinology. 148: 4793-802. PMID 17584965 DOI: 10.1210/En.2006-1568 |
0.704 |
|
| 2007 |
Qin Z, Kastrati I, Chandrasena RE, Liu H, Yao P, Petukhov PA, Bolton JL, Thatcher GR. Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinity. Journal of Medicinal Chemistry. 50: 2682-92. PMID 17489582 DOI: 10.1021/Jm070079J |
0.708 |
|
| 2006 |
Clarke JL, Kastrati I, Johnston LJ, Thatcher GRJ. Photochemical reactions of thiols with organic nitrates - Oxygen atom transfer via a thionitrate Canadian Journal of Chemistry. 84: 709-719. DOI: 10.1139/V06-056 |
0.654 |
|
| 2005 |
Liu J, Liu H, van Breemen RB, Thatcher GR, Bolton JL. Bioactivation of the selective estrogen receptor modulator acolbifene to quinone methides. Chemical Research in Toxicology. 18: 174-82. PMID 15720121 DOI: 10.1021/Tx0497752 |
0.309 |
|
| 2005 |
Liu H, Liu J, van Breemen RB, Thatcher GR, Bolton JL. Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4'-fluoro substitution prevents quinoid formation. Chemical Research in Toxicology. 18: 162-73. PMID 15720120 DOI: 10.1021/Tx049776U |
0.338 |
|
| 1987 |
Kluger R, Thatcher GRJ, Stallings WC. Synthesis, structure, and hydrolysis of esters of strained and unstrained N-phosphonylureas Canadian Journal of Chemistry. 65: 1838-1844. |
0.453 |
|
| 1986 |
Thatcher GRJ, Poirier R, Kluger R. Enzymic carboxyl transfer from N-carboxybiotin. A molecular orbital evaluation of conformational effects in promoting reactivity Journal of the American Chemical Society®. 108: 2699-2704. DOI: 10.1021/Ja00270A031 |
0.451 |
|
| 1986 |
THATCHER GRJ, POIRIER R, KLUGER R. ChemInform Abstract: Enzymic Carboxyl Transfer from N-Carboxybiotin. A MO Evaluation of Conformational Effects in Promoting Reactivity. Chemischer Informationsdienst. 17. DOI: 10.1002/Chin.198637071 |
0.45 |
|
| 1986 |
KLUGER R, THATCHER GRJ. ChemInform Abstract: Exocyclic Cleavage in the Alkaline Hydrolysis of Methyl Ethylene Phosphate. Chemischer Informationsdienst. 17. DOI: 10.1002/chin.198605239 |
0.424 |
|
| 1986 |
Kluger R, Thatcher GRJ. Exocyclic cleavage in the alkaline hydrolysis of methyl ethylene phosphate: Pseudorotation of a pentavalent intermediate or reaction via a hexavalent intermediate? Journal of Organic Chemistry. 51: 207-212. |
0.454 |
|
| 1985 |
Kluger R, Thatcher GRJ. Exocyclic cleavage in the alkaline hydrolysis of methyl ethylene phosphate. Evidence against the significance of stereoelectronic acceleration in reactions of cyclic phosphates Journal of the American Chemical Society. 107: 6006-6011. |
0.452 |
|
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