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Amir Schajnovitz, Ph.D. - Publications

Affiliations: 
2010 Weizmann Institute of Science, Rehovot, Israel 
Area:
Physiology Biology, Cell Biology
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28 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 van Gastel N, Spinelli JB, Sharda A, Schajnovitz A, Baryawno N, Rhee C, Oki T, Grace E, Soled HJ, Milosevic J, Sykes DB, Hsu PP, Vander Heiden MG, Vidoudez C, Trauger SA, et al. Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance. Cell Metabolism. PMID 32763164 DOI: 10.1016/J.Cmet.2020.07.009  0.482
2019 van Gastel N, Spinelli JB, Sharda A, Schajnovitz A, Baryawno N, Rhee CS, Oki T, Grace E, Soled HJ, Vidoudez C, Trauger SA, Haigis MC, Scadden DT. The Distinctive Metabolic Environment of the Bone Marrow Niche Drives Leukemia Chemoresistance Blood. 134: 3725-3725. DOI: 10.1182/Blood-2019-124789  0.508
2018 Shao L, Chang J, Feng W, Wang X, Williamson EA, Li Y, Schajnovitz A, Scadden D, Mortensen LJ, Lin CP, Li L, Paulson A, Downing J, Zhou D, Hromas RA. The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow. Nature Communications. 9: 2377. PMID 29915352 DOI: 10.1038/S41467-018-04716-5  0.439
2018 Mercier F, Shi J, Sykes D, Oki T, Miller E, Vasic R, Zhu A, Severe N, Schajnovitz A, Man C, Kfoury Y, Lee D, Doench J, Hide W, Michor F, et al. In Vivo Profiling of Leukemic Stem Cell Fitness Identifies Therapeutically Actionable Determinants of Growth Experimental Hematology. 64: S86. DOI: 10.1016/J.Exphem.2018.06.095  0.461
2017 Hoggatt J, Singh P, Tate TA, Chou BK, Datari SR, Fukuda S, Liu L, Kharchenko PV, Schajnovitz A, Baryawno N, Mercier FE, Boyer J, Gardner J, Morrow DM, Scadden DT, et al. Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell. Cell. PMID 29224778 DOI: 10.1016/J.Cell.2017.11.003  0.565
2016 Sykes DB, Kfoury YS, Mercier FE, Wawer MJ, Law JM, Haynes MK, Lewis TA, Schajnovitz A, Jain E, Lee D, Meyer H, Pierce KA, Tolliday NJ, Waller A, Ferrara SJ, et al. Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia. Cell. PMID 27641501 DOI: 10.1016/J.Cell.2016.08.057  0.408
2016 Itkin T, Gur-Cohen S, Spencer JA, Schajnovitz A, Ramasamy SK, Kusumbe AP, Ledergor G, Jung Y, Milo I, Poulos MG, Kalinkovich A, Ludin A, Golan K, Khatib E, Kumari A, et al. Corrigendum: Distinct bone marrow blood vessels differentially regulate haematopoiesis. Nature. PMID 27437586 DOI: 10.1038/Nature19088  0.722
2016 Palchaudhuri R, Saez B, Hoggatt J, Schajnovitz A, Sykes DB, Tate TA, Czechowicz A, Kfoury Y, Ruchika F, Rossi DJ, Verdine GL, Mansour MK, Scadden DT. Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin. Nature Biotechnology. PMID 27272386 DOI: 10.1038/Nbt.3584  0.531
2016 Itkin T, Gur-Cohen S, Spencer JA, Schajnovitz A, Ramasamy SK, Kusumbe AP, Ledergor G, Jung Y, Milo I, Poulos MG, Kalinkovich A, Ludin A, Kollet O, Shakhar G, Butler JM, et al. Distinct bone marrow blood vessels differentially regulate haematopoiesis. Nature. PMID 27074509 DOI: 10.1038/Nature17624  0.805
2016 Sykes DB, Kfoury YS, Mercier F, Wawer M, Schajnovitz A, Meyer H, Pierce KA, Stoeckigt D, Clish CB, Clemons PA, Janzer A, Scadden DT. Inhibition of the Enzyme Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia Blood. 128: 1656-1656. DOI: 10.1182/Blood.V128.22.1656.1656  0.503
2015 Itkin T, Gur Cohen S, Spencer JA, Schajnovitz A, Ramasamy SK, Kusumbe AP, Jung Y, Ledergor G, Milo I, Poulos MG, Fernandez MG, Kalinkovich A, Ludin A, Kollet O, Shakhar G, et al. Distinct Bone Marrow Blood Vessels Differentially Regulate Normal and Malignant Hematopoietic Stem and Progenitor Cells Blood. 126: 664-664. DOI: 10.1182/Blood.V126.23.664.664  0.812
2015 Palchaudhuri R, Saez B, Hoggatt J, Schajnovitz A, Sykes DB, Mansour MK, Scadden DT. Immunotoxin Enables Non-Genotoxic Conditioning for Hematopoietic Stem Cell Transplantation Blood. 126: 32-32. DOI: 10.1182/Blood.V126.23.32.32  0.445
2014 Saez B, Ferraro F, Yusuf RZ, Cook CM, Yu VW, Pardo-Saganta A, Sykes SM, Palchaudhuri R, Schajnovitz A, Lotinun S, Lymperi S, Mendez-Ferrer S, Toro RD, Day R, Vasic R, et al. Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning. Blood. 124: 2937-47. PMID 25202142 DOI: 10.1182/Blood-2014-08-593426  0.627
2014 Schajnovitz A, Scadden DT. Bone's dark side: mutated osteoblasts implicated in leukemia. Cell Research. 24: 383-4. PMID 24589711 DOI: 10.1038/Cr.2014.26  0.467
2012 Ludin A, Itkin T, Gur-Cohen S, Mildner A, Shezen E, Golan K, Kollet O, Kalinkovich A, Porat Z, D'Uva G, Schajnovitz A, Voronov E, Brenner DA, Apte RN, Jung S, et al. Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow. Nature Immunology. 13: 1072-82. PMID 22983360 DOI: 10.1038/Ni.2408  0.796
2012 Itkin T, Ludin A, Gradus B, Gur-Cohen S, Kalinkovich A, Schajnovitz A, Ovadya Y, Kollet O, Canaani J, Shezen E, Coffin DJ, Enikolopov GN, Berg T, Piacibello W, Hornstein E, et al. FGF-2 expands murine hematopoietic stem and progenitor cells via proliferation of stromal cells, c-Kit activation, and CXCL12 down-regulation. Blood. 120: 1843-55. PMID 22645180 DOI: 10.1182/Blood-2011-11-394692  0.799
2012 Golan K, Vagima Y, Ludin A, Itkin T, Cohen-Gur S, Kalinkovich A, Kollet O, Kim C, Schajnovitz A, Ovadya Y, Lapid K, Shivtiel S, Morris AJ, Ratajczak MZ, Lapidot T. S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release. Blood. 119: 2478-88. PMID 22279055 DOI: 10.1182/Blood-2011-06-358614  0.778
2011 Dar A, Schajnovitz A, Lapid K, Kalinkovich A, Itkin T, Ludin A, Kao WM, Battista M, Tesio M, Kollet O, Cohen NN, Margalit R, Buss EC, Baleux F, Oishi S, et al. Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells. Leukemia. 25: 1286-96. PMID 21494253 DOI: 10.1038/Leu.2011.62  0.811
2011 Schajnovitz A, Itkin T, D'Uva G, Kalinkovich A, Golan K, Ludin A, Cohen D, Shulman Z, Avigdor A, Nagler A, Kollet O, Seger R, Lapidot T. CXCL12 secretion by bone marrow stromal cells is dependent on cell contact and mediated by connexin-43 and connexin-45 gap junctions. Nature Immunology. 12: 391-8. PMID 21441933 DOI: 10.1038/Ni.2017  0.829
2011 Tesio M, Golan K, Corso S, Giordano S, Schajnovitz A, Vagima Y, Shivtiel S, Kalinkovich A, Caione L, Gammaitoni L, Laurenti E, Buss EC, Shezen E, Itkin T, Kollet O, et al. Enhanced c-Met activity promotes G-CSF-induced mobilization of hematopoietic progenitor cells via ROS signaling. Blood. 117: 419-28. PMID 20585044 DOI: 10.1182/Blood-2009-06-230359  0.805
2011 Dar A, Schajnovitz A, Lapid K, Kalinkovich A, Itkin T, Ludin A, Kao WM, Battista M, Tesio M, Kollet O, Cohen NN, Margalit R, Buss EC, Baleux F, Oishi S, et al. Erratum: Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells (Leukemia (April 2011) DOI:10.1038/leu.2011.62) Leukemia. 25. DOI: 10.1038/Leu.2011.132  0.804
2010 Golan K, Vagima Y, Ludin A, Itkin T, Kalinkovich A, Cohen-Gur S, Kollet O, Schajnovitz A, Shivtiel S, Lapidot T. The Chemotactic Lipid S1P Regulates Hematopoietic Progenitor Cell Egress and Mobilization Via Its Major Receptor S1P1 and by SDF-1 Inhibition In a p38/Akt/mTOR Dependent Manner Blood. 116: 553-553. DOI: 10.1182/Blood.V116.21.553.553  0.786
2009 Itkin T, Ludin A, Schajnovitz A, Kalinkovich A, Kollet O, Coffin DJ, Berg T, Piacibello W, Lapidot T. Expansion of Normal and Leukemic Hematopoietic Progenitor Cells by PTH Requires bFGF Activation of c-Kit and Its Downstream JAK2/STAT5 Signaling. Blood. 114: 2511-2511. DOI: 10.1182/Blood.V114.22.2511.2511  0.819
2008 Shivtiel S, Kollet O, Lapid K, Schajnovitz A, Goichberg P, Kalinkovich A, Shezen E, Tesio M, Netzer N, Petit I, Sharir A, Lapidot T. CD45 regulates retention, motility, and numbers of hematopoietic progenitors, and affects osteoclast remodeling of metaphyseal trabecules. The Journal of Experimental Medicine. 205: 2381-95. PMID 18779349 DOI: 10.1084/Jem.20080072  0.82
2008 Schajnovitz A, Itkin T, Ludin A, Kalinkovich A, Lapid K, Seger R, Lapidot T. Functional SDF-1 Secretion from BM Stromal Cells Is a Cell Contact-Dependent Event Mediated by Cx43 and Cx45 Gap-Junctions Blood. 112: 319-319. DOI: 10.1182/Blood.V112.11.319.319  0.804
2008 Buss EC, Kalinkovich A, Schajnovitz A, Kollet O, Dar A, Tesio M, Fruehauf S, Hotfilder M, Ho AD, Shultz LD, Lapidot T. In Vivo Mobilization of Leukemic Human Precursor-B-ALL Cells by the CXCR4-Antagonist AMD3100 Is Via Secretion of SDF-1 and Synergistically by Catecholamine Action. Blood. 112: 1920-1920. DOI: 10.1182/Blood.V112.11.1920.1920  0.716
2006 Tesio M, Kalinkovich A, Schajnovitz A, Dar A, Kollet O, Goichberg P, Petit I, Giordano S, Aglietta M, Piacibello W, Lapidot T. The Tyrosine Kinase c-Met Is Selectively Expressed on Motile Hematopoietic Progenitors Following G-CSF Administration and Promotes Mobilization by Regulating Stem Cell Niche Components. Blood. 108: 3376-3376. DOI: 10.1182/Blood.V108.11.3376.3376  0.731
2006 Dar A, Kalinkovich A, Netzer N, Margalit R, Schajnovitz A, Baleux F, Tesio M, Petit I, Lapidot T. AMD3100 Signals Via the Nervous System, Inducing Release to the Circulation of Bone Marrow SDF-1, Which Is Crucial for Progenitor Cell Mobilization. Blood. 108: 1315-1315. DOI: 10.1182/Blood.V108.11.1315.1315  0.782
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