| Year |
Citation |
Score |
| 2020 |
Schneider EH, Hofmeister O, Kälble S, Seifert R. Apoptotic and anti-proliferative effect of guanosine and guanosine derivatives in HuT-78 T lymphoma cells. Naunyn-Schmiedeberg's Archives of Pharmacology. PMID 32313990 DOI: 10.1007/S00210-020-01864-8 |
0.319 |
|
| 2020 |
Gibhardt J, Heidemann JL, Bremenkamp R, Rosenberg J, Seifert R, Kaever V, Ficner R, Commichau FM. An extracytoplasmic protein and a moonlighting enzyme modulate synthesis of c-di-AMP in Listeria monocytogenes. Environmental Microbiology. PMID 32250026 DOI: 10.1111/1462-2920.15008 |
0.339 |
|
| 2019 |
Sayner SL, Choi CS, Maulucci ME, Kc R, Zhou C, Scruggs AK, Yarbrough T, Blair LAH, King JAC, Seifert R, Kaever V, Bauer NN. Extracellular vesicles: another compartment for the second messenger, cyclic adenosine monophosphate (cAMP). American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 30758991 DOI: 10.1152/Ajplung.00282.2018 |
0.325 |
|
| 2018 |
Scharrenbroich J, Kaever V, Dove S, Seifert R, Schneider EH. Hydrolysis of the non-canonical cyclic nucleotide cUMP by PDE9A: kinetics and binding mode. Naunyn-Schmiedeberg's Archives of Pharmacology. PMID 30443663 DOI: 10.1007/S00210-018-1582-5 |
0.376 |
|
| 2017 |
Strasser A, Wittmann HJ, Seifert R. Binding Kinetics and Pathways of Ligands to GPCRs. Trends in Pharmacological Sciences. PMID 28645833 DOI: 10.1016/J.Tips.2017.05.005 |
0.329 |
|
| 2017 |
Dessauer CW, Watts VJ, Ostrom RS, Conti M, Dove S, Seifert R. International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases. Pharmacological Reviews. 69: 93-139. PMID 28255005 DOI: 10.1124/Pr.116.013078 |
0.424 |
|
| 2017 |
Schneider EH, Seifert R. Pharmacological Characterization of Human Histamine Receptors and Histamine Receptor Mutantsin the Sf9 Cell Expression System. Handbook of Experimental Pharmacology. PMID 28233175 DOI: 10.1007/164_2016_124 |
0.442 |
|
| 2017 |
Schneider EH, Seifert R. Inactivation of Non-canonical Cyclic Nucleotides: Hydrolysis and Transport. Handbook of Experimental Pharmacology. PMID 28204955 DOI: 10.1007/164_2016_5004 |
0.339 |
|
| 2017 |
Seifert R. cCMP and cUMP Across the Tree of Life: From cCMP and cUMP Generators to cCMP- and cUMP-Regulated Cell Functions. Handbook of Experimental Pharmacology. PMID 28181008 DOI: 10.1007/164_2016_5005 |
0.312 |
|
| 2016 |
Berrisch S, Ostermeyer J, Kaever V, Kälble S, Hilfiker-Kleiner D, Seifert R, Schneider EH. cUMP hydrolysis by PDE3A. Naunyn-Schmiedeberg's Archives of Pharmacology. PMID 27975297 DOI: 10.1007/S00210-016-1328-1 |
0.356 |
|
| 2016 |
Dittmar F, Wolter S, Seifert R. Regulation of apoptosis by cyclic nucleotides in human erythroleukemia (HEL) cells and human myelogenous leukemia (K-562) cells. Biochemical Pharmacology. PMID 27157412 DOI: 10.1016/J.Bcp.2016.04.018 |
0.313 |
|
| 2016 |
Werner K, Neumann D, Seifert R. High constitutive Akt2 activity in U937 promonocytes: effective reduction of Akt2 phosphorylation by the histamine H2-receptor and the β2-adrenergic receptor. Naunyn-Schmiedeberg's Archives of Pharmacology. 389: 87-101. PMID 26475619 DOI: 10.1007/S00210-015-1179-1 |
0.368 |
|
| 2016 |
Karcz T, Handzlik J, Łażewska D, Kottke T, Seifert R, Kieć-Kononowicz K. Search for histamine H4 receptor ligands in the group of 4-methylpiperazino amide derivatives. Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]. S243-5. PMID 20058181 DOI: 10.1007/S00011-009-0141-4 |
0.352 |
|
| 2015 |
Beermann S, Bernhardt G, Seifert R, Buschauer A, Neumann D. Histamine H(1)- and H(4)-receptor signaling cooperatively regulate MAPK activation. Biochemical Pharmacology. 98: 432-9. PMID 26385311 DOI: 10.1016/J.Bcp.2015.09.011 |
0.336 |
|
| 2015 |
Littmann T, Göttle M, Reinartz MT, Kälble S, Wainer IW, Ozawa T, Seifert R. Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands. The Journal of Pharmacology and Experimental Therapeutics. 355: 183-90. PMID 26306764 DOI: 10.1124/Jpet.115.227959 |
0.337 |
|
| 2015 |
Wolter S, Kloth C, Golombek M, Dittmar F, Försterling L, Seifert R. cCMP causes caspase-dependent apoptosis in mouse lymphoma cell lines. Biochemical Pharmacology. 98: 119-31. PMID 26300059 DOI: 10.1016/J.Bcp.2015.08.096 |
0.336 |
|
| 2015 |
Lübker C, Dove S, Tang WJ, Urbauer RJ, Moskovitz J, Urbauer JL, Seifert R. Different Roles of N-Terminal and C-Terminal Domains in Calmodulin for Activation of Bacillus anthracis Edema Factor. Toxins. 7: 2598-614. PMID 26184312 DOI: 10.3390/Toxins7072598 |
0.322 |
|
| 2015 |
Werner K, Kälble S, Wolter S, Schneider EH, Buschauer A, Neumann D, Seifert R. Flow cytometric analysis with a fluorescently labeled formyl peptide receptor ligand as a new method to study the pharmacological profile of the histamine H2 receptor. Naunyn-Schmiedeberg's Archives of Pharmacology. 388: 1039-52. PMID 26021872 DOI: 10.1007/S00210-015-1133-2 |
0.363 |
|
| 2015 |
Lübker C, Seifert R. Effects of 39 Compounds on Calmodulin-Regulated Adenylyl Cyclases AC1 and Bacillus anthracis Edema Factor. Plos One. 10: e0124017. PMID 25946093 DOI: 10.1371/Journal.Pone.0124017 |
0.378 |
|
| 2015 |
Heifetz A, Schertler GF, Seifert R, Tate CG, Sexton PM, Gurevich VV, Fourmy D, Cherezov V, Marshall FH, Storer RI, Moraes I, Tikhonova IG, Tautermann CS, Hunt P, Ceska T, et al. GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014. Naunyn-Schmiedeberg's Archives of Pharmacology. 388: 883-903. PMID 25772061 DOI: 10.1007/S00210-015-1111-8 |
0.305 |
|
| 2015 |
Kagermeier N, Werner K, Keller M, Baumeister P, Bernhardt G, Seifert R, Buschauer A. Dimeric carbamoylguanidine-type histamine H2 receptor ligands: A new class of potent and selective agonists. Bioorganic & Medicinal Chemistry. 23: 3957-69. PMID 25639885 DOI: 10.1016/J.Bmc.2015.01.012 |
0.385 |
|
| 2015 |
Reinartz MT, Kälble S, Wainer IW, Seifert R. Interaction of fenoterol stereoisomers with β2-adrenoceptor-G sα fusion proteins: antagonist and agonist competition binding. Naunyn-Schmiedeberg's Archives of Pharmacology. 388: 517-24. PMID 25637582 DOI: 10.1007/S00210-015-1086-5 |
0.391 |
|
| 2015 |
Michel MC, Seifert R. Selectivity of pharmacological tools: implications for use in cell physiology. A review in the theme: Cell signaling: proteins, pathways and mechanisms. American Journal of Physiology. Cell Physiology. 308: C505-20. PMID 25631871 DOI: 10.1152/Ajpcell.00389.2014 |
0.358 |
|
| 2015 |
Seifert R, Schneider EH, Bähre H. From canonical to non-canonical cyclic nucleotides as second messengers: pharmacological implications. Pharmacology & Therapeutics. 148: 154-84. PMID 25527911 DOI: 10.1016/J.Pharmthera.2014.12.002 |
0.378 |
|
| 2015 |
Lübker C, Urbauer RJ, Moskovitz J, Dove S, Weisemann J, Fedorova M, Urbauer JL, Seifert R. Membranous adenylyl cyclase 1 activation is regulated by oxidation of N- and C-terminal methionine residues in calmodulin. Biochemical Pharmacology. 93: 196-209. PMID 25462816 DOI: 10.1016/J.Bcp.2014.11.007 |
0.331 |
|
| 2015 |
Seifert R. cCMP and cUMP: emerging second messengers. Trends in Biochemical Sciences. 40: 8-15. PMID 25435399 DOI: 10.1016/J.Tibs.2014.10.008 |
0.315 |
|
| 2015 |
Reinartz MT, Kälble S, Littmann T, Ozawa T, Dove S, Kaever V, Wainer IW, Seifert R. Structure-bias relationships for fenoterol stereoisomers in six molecular and cellular assays at the β2-adrenoceptor. Naunyn-Schmiedeberg's Archives of Pharmacology. 388: 51-65. PMID 25342094 DOI: 10.1007/S00210-014-1054-5 |
0.36 |
|
| 2015 |
Wifling D, Löffel K, Nordemann U, Strasser A, Bernhardt G, Dove S, Seifert R, Buschauer A. Molecular determinants for the high constitutive activity of the human histamine H4 receptor: functional studies on orthologues and mutants. British Journal of Pharmacology. 172: 785-798. PMID 24903527 DOI: 10.1111/Bph.12801 |
0.342 |
|
| 2015 |
Seifert R, Hartwig C, Wolter S, Schneider E, Bähre H, Kaever V. cIMP: Synthesis, effector activation, inactivation and occurrence in biological systems Bmc Pharmacology and Toxicology. 16. DOI: 10.1186/2050-6511-16-S1-A85 |
0.344 |
|
| 2015 |
Schneider E, Wolter S, Dittmar F, Fernández G, Seifert R. Differentiation between first and second messenger effects of cGMP Bmc Pharmacology and Toxicology. 16. DOI: 10.1186/2050-6511-16-S1-A84 |
0.335 |
|
| 2014 |
Werner K, Neumann D, Buschauer A, Seifert R. No evidence for histamine H4 receptor in human monocytes. The Journal of Pharmacology and Experimental Therapeutics. 351: 519-26. PMID 25273276 DOI: 10.1124/Jpet.114.218107 |
0.332 |
|
| 2014 |
Beermann S, Vauth M, Hein R, Seifert R, Neumann D. Distinct signalling pathways of murine histamine H1- and H4-receptors expressed at comparable levels in HEK293 cells. Plos One. 9: e107481. PMID 25243776 DOI: 10.1371/Journal.Pone.0107481 |
0.363 |
|
| 2014 |
Werner K, Neumann D, Seifert R. Analysis of the histamine H2-receptor in human monocytes. Biochemical Pharmacology. 92: 369-79. PMID 25199456 DOI: 10.1016/J.Bcp.2014.08.028 |
0.408 |
|
| 2014 |
Wolter S, Dove S, Golombek M, Schwede F, Seifert R. N4-monobutyryl-cCMP activates PKA RIα and PKA RIIα more potently and with higher efficacy than PKG Iα in vitro but not in vivo. Naunyn-Schmiedeberg's Archives of Pharmacology. 387: 1163-75. PMID 25192685 DOI: 10.1007/S00210-014-1042-9 |
0.404 |
|
| 2014 |
Monzel M, Kuhn M, Bähre H, Seifert R, Schneider EH. PDE7A1 hydrolyzes cCMP. Febs Letters. 588: 3469-74. PMID 25128584 DOI: 10.1016/J.Febslet.2014.08.005 |
0.302 |
|
| 2014 |
Beckert U, Grundmann M, Wolter S, Schwede F, Rehmann H, Kaever V, Kostenis E, Seifert R. cNMP-AMs mimic and dissect bacterial nucleotidyl cyclase toxin effects. Biochemical and Biophysical Research Communications. 451: 497-502. PMID 25108158 DOI: 10.1016/J.Bbrc.2014.07.134 |
0.379 |
|
| 2014 |
Wittmann HJ, Seifert R, Strasser A. Sodium binding to hH3R and hH 4R--a molecular modeling study. Journal of Molecular Modeling. 20: 2394. PMID 25098339 DOI: 10.1007/S00894-014-2394-2 |
0.338 |
|
| 2014 |
Hartwig C, Bähre H, Wolter S, Beckert U, Kaever V, Seifert R. cAMP, cGMP, cCMP and cUMP concentrations across the tree of life: High cCMP and cUMP levels in astrocytes. Neuroscience Letters. 579: 183-7. PMID 25062586 DOI: 10.1016/J.Neulet.2014.07.019 |
0.324 |
|
| 2014 |
Beckert U, Wolter S, Hartwig C, Bähre H, Kaever V, Ladant D, Frank DW, Seifert R. ExoY from Pseudomonas aeruginosa is a nucleotidyl cyclase with preference for cGMP and cUMP formation. Biochemical and Biophysical Research Communications. 450: 870-4. PMID 24971548 DOI: 10.1016/J.Bbrc.2014.06.088 |
0.345 |
|
| 2014 |
Seifert R. Therapeutic efficacy of a H₄ receptor antagonist in humans: a milestone in histamine research. The Journal of Pharmacology and Experimental Therapeutics. 350: 2-4. PMID 24925898 DOI: 10.1124/Jpet.114.215749Comm |
0.314 |
|
| 2014 |
Hasan A, Danker KY, Wolter S, Bähre H, Kaever V, Seifert R. Soluble adenylyl cyclase accounts for high basal cCMP and cUMP concentrations in HEK293 and B103 cells. Biochemical and Biophysical Research Communications. 448: 236-40. PMID 24792377 DOI: 10.1016/J.Bbrc.2014.04.099 |
0.385 |
|
| 2014 |
Dove S, Danker KY, Stasch JP, Kaever V, Seifert R. Structure/activity relationships of (M)ANT- and TNP-nucleotides for inhibition of rat soluble guanylyl cyclase α1β1. Molecular Pharmacology. 85: 598-607. PMID 24470063 DOI: 10.1124/Mol.113.091017 |
0.416 |
|
| 2014 |
Bähre H, Danker KY, Stasch JP, Kaever V, Seifert R. Nucleotidyl cyclase activity of soluble guanylyl cyclase in intact cells. Biochemical and Biophysical Research Communications. 443: 1195-9. PMID 24380860 DOI: 10.1016/J.Bbrc.2013.12.108 |
0.355 |
|
| 2014 |
Bräunig JH, Albrecht-Küpper B, Seifert R. Adenylyl cyclase regulation in heart failure due to myocardial infarction in rats. Naunyn-Schmiedeberg's Archives of Pharmacology. 387: 389-98. PMID 24276219 DOI: 10.1007/S00210-013-0943-3 |
0.358 |
|
| 2014 |
Neumann D, Schneider EH, Seifert R. Analysis of histamine receptor knockout mice in models of inflammation. The Journal of Pharmacology and Experimental Therapeutics. 348: 2-11. PMID 24101735 DOI: 10.1124/Jpet.113.204214 |
0.319 |
|
| 2014 |
Reinartz MT, Seifert R. Funktionelle Selektivität am Beispiel des β2-Adrenozeptors Biospektrum. 20: 130-135. DOI: 10.1007/S12268-014-0415-4 |
0.346 |
|
| 2013 |
Seifert R. Correspondence (letter to the editor): Numerous errors. Deutsches äRzteblatt International. 110: 557. PMID 24069080 DOI: 10.3238/Arztebl.2013.0557A |
0.372 |
|
| 2013 |
Nordemann U, Wifling D, Schnell D, Bernhardt G, Stark H, Seifert R, Buschauer A. Luciferase reporter gene assay on human, murine and rat histamine H4 receptor orthologs: correlations and discrepancies between distal and proximal readouts. Plos One. 8: e73961. PMID 24023919 DOI: 10.1371/Journal.Pone.0073961 |
0.395 |
|
| 2013 |
Beckert U, Aw WY, Burhenne H, Försterling L, Kaever V, Timmons L, Seifert R. The Receptor-Bound Guanylyl Cyclase DAF-11 Is the Mediator of Hydrogen Peroxide-Induced cGMP Increase in Caenorhabditis elegans [corrected].. Plos One. 8: e72569. PMID 24015261 DOI: 10.1371/Journal.Pone.0072569 |
0.362 |
|
| 2013 |
Seifert R. Functional selectivity of G-protein-coupled receptors: from recombinant systems to native human cells. Biochemical Pharmacology. 86: 853-61. PMID 23933388 DOI: 10.1016/J.Bcp.2013.07.029 |
0.372 |
|
| 2013 |
Beste KY, Spangler CM, Burhenne H, Koch KW, Shen Y, Tang WJ, Kaever V, Seifert R. Nucleotidyl cyclase activity of particulate guanylyl cyclase A: comparison with particulate guanylyl cyclases E and F, soluble guanylyl cyclase and bacterial adenylyl cyclases CyaA and edema factor. Plos One. 8: e70223. PMID 23922959 DOI: 10.1371/Journal.Pone.0070223 |
0.359 |
|
| 2013 |
Seifert R, Dove S. Inhibitors of Bacillus anthracis edema factor. Pharmacology & Therapeutics. 140: 200-12. PMID 23850654 DOI: 10.1016/J.Pharmthera.2013.07.002 |
0.39 |
|
| 2013 |
Braeunig JH, Schweda F, Han PL, Seifert R. Similarly potent inhibition of adenylyl cyclase by P-site inhibitors in hearts from wild type and AC5 knockout mice. Plos One. 8: e68009. PMID 23840883 DOI: 10.1371/Journal.Pone.0068009 |
0.351 |
|
| 2013 |
Brunskole Hummel I, Reinartz MT, Kälble S, Burhenne H, Schwede F, Buschauer A, Seifert R. Dissociations in the effects of β2-adrenergic receptor agonists on cAMP formation and superoxide production in human neutrophils: support for the concept of functional selectivity. Plos One. 8: e64556. PMID 23741338 DOI: 10.1371/Journal.Pone.0064556 |
0.382 |
|
| 2013 |
Seifert R. Regulation of G protein subunit composition in cardiomyocytes: pharmacological implications. Naunyn-Schmiedeberg's Archives of Pharmacology. 386: 455-7. PMID 23568551 DOI: 10.1007/S00210-013-0864-1 |
0.317 |
|
| 2013 |
Reinecke D, Schwede F, Genieser HG, Seifert R. Analysis of substrate specificity and kinetics of cyclic nucleotide phosphodiesterases with N'-methylanthraniloyl-substituted purine and pyrimidine 3',5'-cyclic nucleotides by fluorescence spectrometry. Plos One. 8: e54158. PMID 23342095 DOI: 10.1371/Journal.Pone.0054158 |
0.379 |
|
| 2013 |
Seifert R, Strasser A, Schneider EH, Neumann D, Dove S, Buschauer A. Molecular and cellular analysis of human histamine receptor subtypes. Trends in Pharmacological Sciences. 34: 33-58. PMID 23254267 DOI: 10.1016/J.Tips.2012.11.001 |
0.318 |
|
| 2013 |
Strasser A, Wittmann HJ, Buschauer A, Schneider EH, Seifert R. Species-dependent activities of G-protein-coupled receptor ligands: lessons from histamine receptor orthologs. Trends in Pharmacological Sciences. 34: 13-32. PMID 23228711 DOI: 10.1016/J.Tips.2012.10.004 |
0.364 |
|
| 2013 |
Beste KY, Seifert R. cCMP, cUMP, cTMP, cIMP and cXMP as possible second messengers: development of a hypothesis based on studies with soluble guanylyl cyclase α(1)β(1). Biological Chemistry. 394: 261-70. PMID 23087103 DOI: 10.1515/Hsz-2012-0282 |
0.337 |
|
| 2013 |
Wolter S, Golombek M, Schwede F, Genieser H, Dove S, Seifert R. Activation profile of cGMP-dependent protein kinase Iα Bmc Pharmacology and Toxicology. 14. DOI: 10.1186/2050-6511-14-S1-P79 |
0.404 |
|
| 2013 |
Schneider E, Kuhn M, Reinecke D, Wolter S, Burhenne H, Kaever V, Seifert R. Fishing for elusive cCMP-degrading phosphodiesterases Bmc Pharmacology and Toxicology. 14. DOI: 10.1186/2050-6511-14-S1-P62 |
0.323 |
|
| 2013 |
Seifert R, Hartwig C, Wolter S, Reinecke D, Burhenne H, Kaever V, Munder A, Tümmler B, Schwede F, Grundmann M, Kostenis E, Frank DW, Beckert U. Pseudomonas aeruginosaExoY, a cyclic GMP- and cyclic UMP-generating nucleotidyl cyclase Bmc Pharmacology and Toxicology. 14. DOI: 10.1186/2050-6511-14-S1-O36 |
0.363 |
|
| 2012 |
Seifert R, Beste KY. Allosteric regulation of nucleotidyl cyclases: an emerging pharmacological target. Science Signaling. 5: pe37. PMID 22949734 DOI: 10.1126/Scisignal.2003466 |
0.327 |
|
| 2012 |
Reher TM, Brunskole I, Neumann D, Seifert R. Evidence for ligand-specific conformations of the histamine H(2)-receptor in human eosinophils and neutrophils. Biochemical Pharmacology. 84: 1174-85. PMID 22922404 DOI: 10.1016/J.Bcp.2012.08.014 |
0.341 |
|
| 2012 |
Göttle M, Dove S, Seifert R. Bacillus anthracis edema factor substrate specificity: evidence for new modes of action. Toxins. 4: 505-35. PMID 22852066 DOI: 10.3390/Toxins4070505 |
0.359 |
|
| 2012 |
Hammerschmidt A, Chatterji B, Zeiser J, Schröder A, Genieser HG, Pich A, Kaever V, Schwede F, Wolter S, Seifert R. Binding of regulatory subunits of cyclic AMP-dependent protein kinase to cyclic CMP agarose. Plos One. 7: e39848. PMID 22808067 DOI: 10.1371/Journal.Pone.0039848 |
0.362 |
|
| 2012 |
Gorinski N, Kowalsman N, Renner U, Wirth A, Reinartz MT, Seifert R, Zeug A, Ponimaskin E, Niv MY. Computational and experimental analysis of the transmembrane domain 4/5 dimerization interface of the serotonin 5-HT(1A) receptor. Molecular Pharmacology. 82: 448-63. PMID 22669805 DOI: 10.1124/Mol.112.079137 |
0.308 |
|
| 2012 |
Seifert R, Dove S. Towards selective inhibitors of adenylyl cyclase toxin from Bordetella pertussis. Trends in Microbiology. 20: 343-51. PMID 22578665 DOI: 10.1016/J.Tim.2012.04.002 |
0.369 |
|
| 2012 |
Kinast L, von der Ohe J, Burhenne H, Seifert R. Impairment of adenylyl cyclase 2 function and expression in hypoxanthine phosphoribosyltransferase-deficient rat B103 neuroblastoma cells as model for Lesch-Nyhan disease: BODIPY-forskolin as pharmacological tool. Naunyn-Schmiedeberg's Archives of Pharmacology. 385: 671-83. PMID 22552731 DOI: 10.1007/S00210-012-0759-6 |
0.373 |
|
| 2012 |
Reher TM, Neumann D, Buschauer A, Seifert R. Incomplete activation of human eosinophils via the histamine H4-receptor: evidence for ligand-specific receptor conformations. Biochemical Pharmacology. 84: 192-203. PMID 22516788 DOI: 10.1016/J.Bcp.2012.04.004 |
0.341 |
|
| 2012 |
Schuler D, Lübker C, Lushington GH, Tang WJ, Shen Y, Richter M, Seifert R. Interactions of Bordetella pertussis adenylyl cyclase toxin CyaA with calmodulin mutants and calmodulin antagonists: comparison with membranous adenylyl cyclase I. Biochemical Pharmacology. 83: 839-48. PMID 22265637 DOI: 10.1016/J.Bcp.2012.01.005 |
0.385 |
|
| 2012 |
Birnkammer T, Spickenreither A, Brunskole I, Lopuch M, Kagermeier N, Bernhardt G, Dove S, Seifert R, Elz S, Buschauer A. The bivalent ligand approach leads to highly potent and selective acylguanidine-type histamine H₂ receptor agonists. Journal of Medicinal Chemistry. 55: 1147-60. PMID 22216892 DOI: 10.1021/Jm201128Q |
0.336 |
|
| 2012 |
Beste KY, Burhenne H, Kaever V, Stasch JP, Seifert R. Nucleotidyl cyclase activity of soluble guanylyl cyclase α1β1. Biochemistry. 51: 194-204. PMID 22122229 DOI: 10.1021/Bi201259Y |
0.42 |
|
| 2012 |
Seifert R, Lushington GH, Mou TC, Gille A, Sprang SR. Inhibitors of membranous adenylyl cyclases. Trends in Pharmacological Sciences. 33: 64-78. PMID 22100304 DOI: 10.1016/J.Tips.2011.10.006 |
0.706 |
|
| 2012 |
Beermann S, Seifert R, Neumann D. Commercially available antibodies against human and murine histamine H₄-receptor lack specificity. Naunyn-Schmiedeberg's Archives of Pharmacology. 385: 125-35. PMID 22071576 DOI: 10.1007/S00210-011-0700-4 |
0.311 |
|
| 2012 |
Appl H, Holzammer T, Dove S, Haen E, Strasser A, Seifert R. Interactions of recombinant human histamine H₁R, H₂R, H₃R, and H₄R receptors with 34 antidepressants and antipsychotics. Naunyn-Schmiedeberg's Archives of Pharmacology. 385: 145-70. PMID 22033803 DOI: 10.1007/S00210-011-0704-0 |
0.365 |
|
| 2012 |
Taha H, Dove S, Geduhn J, König B, Shen Y, Tang WJ, Seifert R. Inhibition of the adenylyl cyclase toxin, edema factor, from Bacillus anthracis by a series of 18 mono- and bis-(M)ANT-substituted nucleoside 5'-triphosphates. Naunyn-Schmiedeberg's Archives of Pharmacology. 385: 57-68. PMID 21947230 DOI: 10.1007/S00210-011-0688-9 |
0.405 |
|
| 2012 |
Beste KY, Burhenne H, Kaever V, Stasch J, Seifert R. Correction to Nucleotidyl Cyclase Activity of Soluble Guanylyl Cyclase α1β1 Biochemistry. 51: 2357-2357. DOI: 10.1021/Bi3002715 |
0.329 |
|
| 2011 |
Wolter S, Golombek M, Seifert R. Differential activation of cAMP- and cGMP-dependent protein kinases by cyclic purine and pyrimidine nucleotides. Biochemical and Biophysical Research Communications. 415: 563-6. PMID 22074826 DOI: 10.1016/J.Bbrc.2011.10.093 |
0.369 |
|
| 2011 |
Erdorf M, von der Ohe J, Seifert R. Impaired P2X and P2Y receptor-mediated signaling in HPRT-deficient B103 neuroblastoma cells. Neuroscience Letters. 504: 311-5. PMID 21982803 DOI: 10.1016/J.Neulet.2011.09.054 |
0.347 |
|
| 2011 |
Wittmann HJ, Seifert R, Strasser A. Influence of the N-terminus and the E2-loop onto the binding kinetics of the antagonist mepyramine and the partial agonist phenoprodifen to H(1)R. Biochemical Pharmacology. 82: 1910-8. PMID 21933664 DOI: 10.1016/J.Bcp.2011.09.005 |
0.324 |
|
| 2011 |
Reinecke D, Burhenne H, Sandner P, Kaever V, Seifert R. Human cyclic nucleotide phosphodiesterases possess a much broader substrate-specificity than previously appreciated. Febs Letters. 585: 3259-62. PMID 21920362 DOI: 10.1016/J.Febslet.2011.09.004 |
0.342 |
|
| 2011 |
Erdorf M, Mou TC, Seifert R. Impact of divalent metal ions on regulation of adenylyl cyclase isoforms by forskolin analogs. Biochemical Pharmacology. 82: 1673-81. PMID 21843517 DOI: 10.1016/J.Bcp.2011.07.099 |
0.369 |
|
| 2011 |
Wittmann HJ, Elz S, Seifert R, Straber A. N (α)-Methylated phenylhistamines exhibit affinity to the hH(4)R-a pharmacological and molecular modelling study. Naunyn-Schmiedeberg's Archives of Pharmacology. 384: 287-99. PMID 21800095 DOI: 10.1007/S00210-011-0671-5 |
0.302 |
|
| 2011 |
Brunskole I, Strasser A, Seifert R, Buschauer A. Role of the second and third extracellular loops of the histamine H(4) receptor in receptor activation. Naunyn-Schmiedeberg's Archives of Pharmacology. 384: 301-17. PMID 21800093 DOI: 10.1007/S00210-011-0673-3 |
0.307 |
|
| 2011 |
Pop N, Igel P, Brennauer A, Cabrele C, Bernhardt GN, Seifert R, Buschauer A. Functional reconstitution of human neuropeptide Y (NPY) Y(2) and Y(4) receptors in Sf9 insect cells. Journal of Receptor and Signal Transduction Research. 31: 271-85. PMID 21745157 DOI: 10.3109/10799893.2011.583253 |
0.341 |
|
| 2011 |
Sutor S, Heilmann J, Seifert R. Impact of fusion to Gα i2 and co-expression with RGS proteins on pharmacological properties of human cannabinoid receptors CB 1R and CB 2R Journal of Pharmacy and Pharmacology. 63: 1043-1055. PMID 21718288 DOI: 10.1111/J.2042-7158.2011.01307.X |
0.364 |
|
| 2011 |
Rossbach K, Nassenstein C, Gschwandtner M, Schnell D, Sander K, Seifert R, Stark H, Kietzmann M, Bäumer W. Histamine H1, H3 and H4 receptors are involved in pruritus. Neuroscience. 190: 89-102. PMID 21689731 DOI: 10.1016/J.Neuroscience.2011.06.002 |
0.3 |
|
| 2011 |
Pinto C, Lushington GH, Richter M, Gille A, Geduhn J, König B, Mou TC, Sprang SR, Seifert R. Structure-activity relationships for the interactions of 2'- and 3'-(O)-(N-methyl)anthraniloyl-substituted purine and pyrimidine nucleotides with mammalian adenylyl cyclases. Biochemical Pharmacology. 82: 358-70. PMID 21620805 DOI: 10.1016/J.Bcp.2011.05.010 |
0.796 |
|
| 2011 |
Hübner M, Dixit A, Mou TC, Lushington GH, Pinto C, Gille A, Geduhn J, König B, Sprang SR, Seifert R. Structural basis for the high-affinity inhibition of mammalian membranous adenylyl cyclase by 2',3'-o-(N-methylanthraniloyl)-inosine 5'-triphosphate. Molecular Pharmacology. 80: 87-96. PMID 21498658 DOI: 10.1124/Mol.111.071894 |
0.789 |
|
| 2011 |
Więcek M, Kottke T, Ligneau X, Schunack W, Seifert R, Stark H, Handzlik J, Kieć-Kononowicz K. N-Alkenyl and cycloalkyl carbamates as dual acting histamine H3 and H4 receptor ligands. Bioorganic & Medicinal Chemistry. 19: 2850-8. PMID 21498080 DOI: 10.1016/J.Bmc.2011.03.046 |
0.35 |
|
| 2011 |
Hübner M, Dizayee S, Matthes J, Seifert R, Herzig S. Effect of MANT-nucleotides on L-type calcium currents in murine cardiomyocytes. Naunyn-Schmiedeberg's Archives of Pharmacology. 383: 573-83. PMID 21484439 DOI: 10.1007/S00210-011-0626-X |
0.351 |
|
| 2011 |
Schnell D, Brunskole I, Ladova K, Schneider EH, Igel P, Dove S, Buschauer A, Seifert R. Expression and functional properties of canine, rat, and murine histamine H₄ receptors in Sf9 insect cells. Naunyn-Schmiedeberg's Archives of Pharmacology. 383: 457-70. PMID 21359967 DOI: 10.1007/S00210-011-0612-3 |
0.343 |
|
| 2011 |
Erdorf M, Seifert R. Pharmacological characterization of adenylyl cyclase isoforms in rabbit kidney membranes. Naunyn-Schmiedeberg's Archives of Pharmacology. 383: 357-72. PMID 21279330 DOI: 10.1007/S00210-011-0600-7 |
0.364 |
|
| 2011 |
Seifert R, Schneider EH, Dove S, Brunskole I, Neumann D, Strasser A, Buschauer A. Paradoxical stimulatory effects of the "standard" histamine H4-receptor antagonist JNJ7777120: the H4 receptor joins the club of 7 transmembrane domain receptors exhibiting functional selectivity. Molecular Pharmacology. 79: 631-8. PMID 21266488 DOI: 10.1124/Mol.111.071266 |
0.387 |
|
| 2011 |
Kottke T, Sander K, Weizel L, Schneider EH, Seifert R, Stark H. Receptor-specific functional efficacies of alkyl imidazoles as dual histamine H3/H4 receptor ligands. European Journal of Pharmacology. 654: 200-8. PMID 21237145 DOI: 10.1016/J.Ejphar.2010.12.033 |
0.338 |
|
| 2011 |
Geduhn J, Dove S, Shen Y, Tang WJ, König B, Seifert R. Bis-halogen-anthraniloyl-substituted nucleoside 5'-triphosphates as potent and selective inhibitors of Bordetella pertussis adenylyl cyclase toxin. The Journal of Pharmacology and Experimental Therapeutics. 336: 104-15. PMID 20962032 DOI: 10.1124/Jpet.110.174219 |
0.409 |
|
| 2011 |
Wolter S, Golombek M, Hammerschmidt A, Schwede F, Genieser H, Seifert R. Activation of cGMP-dependent protein kinase Iα and cAMP-dependent protein kinase A isoforms by cyclic nucleotides Bmc Pharmacology. 11. DOI: 10.1186/1471-2210-11-S1-P76 |
0.388 |
|
| 2011 |
Voigt U, Burhenne H, Sonnow L, Wölfel C, Spangler C, Ladant D, Frank DW, Kaever V, Seifert R. The effector protein ExoY secreted by Pseudomonas aeruginosa is a nucleotidyl cyclase with preference for GTP Bmc Pharmacology. 11. DOI: 10.1186/1471-2210-11-S1-P74 |
0.344 |
|
| 2011 |
Beste KY, Stasch J, Kaever V, Seifert R. Evidence for two catalytic centers and Mn2+ as physiological cofactor of soluble guanylyl cyclase Bmc Pharmacology. 11. DOI: 10.1186/1471-2210-11-S1-P7 |
0.381 |
|
| 2011 |
Seifert R, Beste K, Burhenne H, Voigt U, Wolter S, Hammerschmidt A, Reinecke D, Sandner P, Pich A, Schwede F, Genieser HG, Kaever V. Cyclic CMP and cyclic UMP: new (old) second messengers Bmc Pharmacology. 11. DOI: 10.1186/1471-2210-11-S1-O34 |
0.345 |
|
| 2010 |
Schneider EH, Seifert R. Coexpression systems as models for the analysis of constitutive GPCR activity. Methods in Enzymology. 485: 527-57. PMID 21050935 DOI: 10.1016/B978-0-12-381296-4.00028-2 |
0.317 |
|
| 2010 |
Schneider EH, Seifert R. Fusion proteins as model systems for the analysis of constitutive GPCR activity. Methods in Enzymology. 485: 459-80. PMID 21050932 DOI: 10.1016/B978-0-12-381296-4.00025-7 |
0.368 |
|
| 2010 |
Spangler C, Kaever V, Seifert R. Interaction of the diguanylate cyclase YdeH of Escherichia coli with 2',(3')-substituted purine and pyrimidine nucleotides. The Journal of Pharmacology and Experimental Therapeutics. 336: 234-41. PMID 20947637 DOI: 10.1124/Jpet.110.170993 |
0.4 |
|
| 2010 |
Schneider EH, Seifert R. Sf9 cells: a versatile model system to investigate the pharmacological properties of G protein-coupled receptors. Pharmacology & Therapeutics. 128: 387-418. PMID 20705094 DOI: 10.1016/J.Pharmthera.2010.07.005 |
0.4 |
|
| 2010 |
Desch M, Schinner E, Kees F, Hofmann F, Seifert R, Schlossmann J. Cyclic cytidine 3',5'-monophosphate (cCMP) signals via cGMP kinase I. Febs Letters. 584: 3979-84. PMID 20691687 DOI: 10.1016/J.Febslet.2010.07.059 |
0.347 |
|
| 2010 |
Schnell D, Strasser A, Seifert R. Comparison of the pharmacological properties of human and rat histamine H(3)-receptors. Biochemical Pharmacology. 80: 1437-49. PMID 20688049 DOI: 10.1016/J.Bcp.2010.07.027 |
0.334 |
|
| 2010 |
Geiger S, Nickl K, Schneider EH, Seifert R, Heilmann J. Establishment of recombinant cannabinoid receptor assays and characterization of several natural and synthetic ligands. Naunyn-Schmiedeberg's Archives of Pharmacology. 382: 177-91. PMID 20617431 DOI: 10.1007/S00210-010-0534-5 |
0.379 |
|
| 2010 |
Göttle M, Dove S, Kees F, Schlossmann J, Geduhn J, König B, Shen Y, Tang WJ, Kaever V, Seifert R. Cytidylyl and uridylyl cyclase activity of bacillus anthracis edema factor and Bordetella pertussis CyaA. Biochemistry. 49: 5494-503. PMID 20521845 DOI: 10.1021/Bi100684G |
0.38 |
|
| 2010 |
Schneider EH, Strasser A, Thurmond RL, Seifert R. Structural requirements for inverse agonism and neutral antagonism of indole-, benzimidazole-, and thienopyrrole-derived histamine H4 receptor ligands. The Journal of Pharmacology and Experimental Therapeutics. 334: 513-21. PMID 20484153 DOI: 10.1124/Jpet.110.165977 |
0.345 |
|
| 2010 |
Sander K, Kottke T, Hoffend C, Walter M, Weizel L, Camelin JC, Ligneau X, Schneider EH, Seifert R, Schwartz JC, Stark H. First metal-containing histamine H3 receptor ligands. Organic Letters. 12: 2578-81. PMID 20446742 DOI: 10.1021/Ol100419Y |
0.321 |
|
| 2010 |
Ghorai P, Kraus A, Birnkammer T, Geyer R, Bernhardt G, Dove S, Seifert R, Elz S, Buschauer A. Chiral NG-acylated hetarylpropylguanidine-type histamine H2 receptor agonists do not show significant stereoselectivity. Bioorganic & Medicinal Chemistry Letters. 20: 3173-6. PMID 20409707 DOI: 10.1016/J.Bmcl.2010.03.082 |
0.324 |
|
| 2010 |
Schnell D, Seifert R. Modulation of histamine H(3) receptor function by monovalent ions. Neuroscience Letters. 472: 114-8. PMID 20132865 DOI: 10.1016/J.Neulet.2010.01.065 |
0.413 |
|
| 2010 |
Schneider EH, Schnell D, Strasser A, Dove S, Seifert R. Impact of the DRY motif and the missing "ionic lock" on constitutive activity and G-protein coupling of the human histamine H4 receptor. The Journal of Pharmacology and Experimental Therapeutics. 333: 382-92. PMID 20106995 DOI: 10.1124/Jpet.109.163220 |
0.333 |
|
| 2010 |
Kuder KJ, Kottke T, Stark H, Ligneau X, Camelin JC, Seifert R, Kieć-Kononowicz K. Search for novel, high affinity histamine H3 receptor ligands with fluorescent properties. Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]. S247-8. PMID 20091085 DOI: 10.1007/S00011-009-0142-3 |
0.309 |
|
| 2010 |
Emmrich T, El-Tayeb A, Taha H, Seifert R, Müller CE, Link A. Synthesis of a hydrolytically stable, fluorescent-labeled ATP analog as a tool for probing adenylyl cyclases. Bioorganic & Medicinal Chemistry Letters. 20: 232-5. PMID 19914832 DOI: 10.1016/J.Bmcl.2009.10.125 |
0.34 |
|
| 2009 |
Schnell D, Burleigh K, Trick J, Seifert R. No evidence for functional selectivity of proxyfan at the human histamine H3 receptor coupled to defined Gi/Go protein heterotrimers. The Journal of Pharmacology and Experimental Therapeutics. 332: 996-1005. PMID 19959746 DOI: 10.1124/Jpet.109.162339 |
0.389 |
|
| 2009 |
Łazewska D, Wiecek M, Ligneau X, Kottke T, Weizel L, Seifert R, Schunack W, Stark H, Kieć-Kononowicz K. Histamine H3 and H4 receptor affinity of branched 3-(1H-imidazol-4-yl)propyl N-alkylcarbamates. Bioorganic & Medicinal Chemistry Letters. 19: 6682-5. PMID 19846299 DOI: 10.1016/J.Bmcl.2009.10.005 |
0.31 |
|
| 2009 |
Igel P, Geyer R, Strasser A, Dove S, Seifert R, Buschauer A. Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H4 receptor agonists. Journal of Medicinal Chemistry. 52: 6297-313. PMID 19791743 DOI: 10.1021/Jm900526H |
0.386 |
|
| 2009 |
Suryanarayana S, Pinto C, Mou TC, Richter M, Lushington GH, Seifert R. The C1 homodimer of adenylyl cyclase binds nucleotides with high affinity but possesses exceedingly low catalytic activity. Neuroscience Letters. 467: 1-5. PMID 19788911 DOI: 10.1016/J.Neulet.2009.09.049 |
0.794 |
|
| 2009 |
Sander K, Kottke T, Tanrikulu Y, Proschak E, Weizel L, Schneider EH, Seifert R, Schneider G, Stark H. 2,4-Diaminopyrimidines as histamine H4 receptor ligands--Scaffold optimization and pharmacological characterization. Bioorganic & Medicinal Chemistry. 17: 7186-96. PMID 19773175 DOI: 10.1016/J.Bmc.2009.08.059 |
0.345 |
|
| 2009 |
Deml KF, Beermann S, Neumann D, Strasser A, Seifert R. Interactions of histamine H1-receptor agonists and antagonists with the human histamine H4-receptor. Molecular Pharmacology. 76: 1019-30. PMID 19720730 DOI: 10.1124/Mol.109.058651 |
0.366 |
|
| 2009 |
Suryanarayana S, Göttle M, Hübner M, Gille A, Mou TC, Sprang SR, Richter M, Seifert R. Differential inhibition of various adenylyl cyclase isoforms and soluble guanylyl cyclase by 2',3'-O-(2,4,6-trinitrophenyl)-substituted nucleoside 5'-triphosphates. The Journal of Pharmacology and Experimental Therapeutics. 330: 687-95. PMID 19494187 DOI: 10.1124/Jpet.109.155432 |
0.721 |
|
| 2009 |
Suryanarayana S, Wang JL, Richter M, Shen Y, Tang WJ, Lushington GH, Seifert R. Distinct interactions of 2'- and 3'-O-(N-methyl)anthraniloyl-isomers of ATP and GTP with the adenylyl cyclase toxin of Bacillus anthracis, edema factor. Biochemical Pharmacology. 78: 224-30. PMID 19492438 DOI: 10.1016/J.Bcp.2009.04.006 |
0.399 |
|
| 2009 |
Schneider EH, Seifert R. Histamine H(4) receptor-RGS fusion proteins expressed in Sf9 insect cells: a sensitive and reliable approach for the functional characterization of histamine H(4) receptor ligands. Biochemical Pharmacology. 78: 607-16. PMID 19464266 DOI: 10.1016/J.Bcp.2009.05.015 |
0.358 |
|
| 2009 |
Pinto C, Hübner M, Gille A, Richter M, Mou TC, Sprang SR, Seifert R. Differential interactions of the catalytic subunits of adenylyl cyclase with forskolin analogs. Biochemical Pharmacology. 78: 62-9. PMID 19447224 DOI: 10.1016/J.Bcp.2009.03.023 |
0.777 |
|
| 2009 |
Wittmann HJ, Seifert R, Strasser A. Contribution of binding enthalpy and entropy to affinity of antagonist and agonist binding at human and guinea pig histamine H(1)-receptor. Molecular Pharmacology. 76: 25-37. PMID 19346300 DOI: 10.1124/Mol.109.055384 |
0.319 |
|
| 2009 |
Tanrikulu Y, Proschak E, Werner T, Geppert T, Todoroff N, Klenner A, Kottke T, Sander K, Schneider E, Seifert R, Stark H, Clark T, Schneider G. Homology model adjustment and ligand screening with a pseudoreceptor of the human histamine H4 receptor. Chemmedchem. 4: 820-7. PMID 19343764 DOI: 10.1002/Cmdc.200800443 |
0.328 |
|
| 2009 |
Igel P, Schneider E, Schnell D, Elz S, Seifert R, Buschauer A. N(G)-acylated imidazolylpropylguanidines as potent histamine H4 receptor agonists: selectivity by variation of the N(G)-substituent. Journal of Medicinal Chemistry. 52: 2623-7. PMID 19317445 DOI: 10.1021/Jm9000693 |
0.329 |
|
| 2009 |
Göttle M, Geduhn J, König B, Gille A, Höcherl K, Seifert R. Characterization of mouse heart adenylyl cyclase. The Journal of Pharmacology and Experimental Therapeutics. 329: 1156-65. PMID 19307450 DOI: 10.1124/Jpet.109.150953 |
0.677 |
|
| 2009 |
Schneider EH, Schnell D, Papa D, Seifert R. High constitutive activity and a G-protein-independent high-affinity state of the human histamine H(4)-receptor. Biochemistry. 48: 1424-38. PMID 19166345 DOI: 10.1021/Bi802050D |
0.405 |
|
| 2009 |
Igel P, Schnell D, Bernhardt G, Seifert R, Buschauer A. Tritium-labeled N(1)-[3-(1H-imidazol-4-yl)propyl]-N(2)-propionylguanidine ([(3)H]UR-PI294), a high-affinity histamine H(3) and H(4) receptor radioligand. Chemmedchem. 4: 225-31. PMID 19101971 DOI: 10.1002/Cmdc.200800349 |
0.312 |
|
| 2009 |
Kraus A, Ghorai P, Birnkammer T, Schnell D, Elz S, Seifert R, Dove S, Bernhardt G, Buschauer A. N(G)-acylated aminothiazolylpropylguanidines as potent and selective histamine H(2) receptor agonists. Chemmedchem. 4: 232-40. PMID 19072936 DOI: 10.1002/Cmdc.200800296 |
0.367 |
|
| 2009 |
Taha HM, Schmidt J, Göttle M, Suryanarayana S, Shen Y, Tang WJ, Gille A, Geduhn J, König B, Dove S, Seifert R. Molecular analysis of the interaction of anthrax adenylyl cyclase toxin, edema factor, with 2'(3')-O-(N-(methyl)anthraniloyl)-substituted purine and pyrimidine nucleotides. Molecular Pharmacology. 75: 693-703. PMID 19056899 DOI: 10.1124/Mol.108.052340 |
0.72 |
|
| 2009 |
Strasser A, Wittmann HJ, Kunze M, Elz S, Seifert R. Molecular basis for the selective interaction of synthetic agonists with the human histamine H1-receptor compared with the guinea pig H1-receptor. Molecular Pharmacology. 75: 454-65. PMID 19047480 DOI: 10.1124/Mol.108.053009 |
0.343 |
|
| 2009 |
Spangler CM, Wilhelm B, Burhenne H, Rauch K, Seifert R, Kaever V. Sensitive assay for the detection of cyclic nucleotides by mass spectrometry Bmc Pharmacology. 9. DOI: 10.1186/1471-2210-9-S1-P66 |
0.313 |
|
| 2009 |
Göttle M, Kees F, Seifert R. Cytidylyl cyclase activity of bacterial exotoxins Bmc Pharmacology. 9: P16. DOI: 10.1186/1471-2210-9-S1-P16 |
0.368 |
|
| 2009 |
Egger M, Maity P, Hübner M, Seifert R, König B. Synthesis and Pharmacological Properties of New Tetracyclic Forskolin Analogues European Journal of Organic Chemistry. 2009: 3613-3618. DOI: 10.1002/Ejoc.200900260 |
0.33 |
|
| 2008 |
Seifert R, Dove S. Functional selectivity of GPCR ligand stereoisomers: new pharmacological opportunities. Molecular Pharmacology. 75: 13-8. PMID 19001067 DOI: 10.1124/Mol.108.052944 |
0.356 |
|
| 2008 |
Egger M, Pellett P, Nickl K, Geiger S, Graetz S, Seifert R, Heilmann J, König B. Synthesis and cannabinoid receptor activity of ketoalkenes from Echinacea pallida and nonnatural analogues. Chemistry (Weinheim An Der Bergstrasse, Germany). 14: 10978-84. PMID 18979494 DOI: 10.1002/Chem.200801579 |
0.314 |
|
| 2008 |
Ghorai P, Kraus A, Keller M, Götte C, Igel P, Schneider E, Schnell D, Bernhardt G, Dove S, Zabel M, Elz S, Seifert R, Buschauer A. Acylguanidines as bioisosteres of guanidines: NG-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists. Journal of Medicinal Chemistry. 51: 7193-204. PMID 18950149 DOI: 10.1021/Jm800841W |
0.35 |
|
| 2008 |
Nickl K, Gardner EE, Geiger S, Heilmann J, Seifert R. Differential coupling of the human cannabinoid receptors hCB1R and hCB2R to the G-protein G(alpha)i2beta1gamma2. Neuroscience Letters. 447: 68-72. PMID 18845226 DOI: 10.1016/J.Neulet.2008.09.078 |
0.316 |
|
| 2008 |
Weitl N, Seifert R. Distinct interactions of human beta1- and beta2-adrenoceptors with isoproterenol, epinephrine, norepinephrine, and dopamine. The Journal of Pharmacology and Experimental Therapeutics. 327: 760-9. PMID 18772317 DOI: 10.1124/Jpet.108.143412 |
0.334 |
|
| 2008 |
Spangler CM, Spangler C, Göttle M, Shen Y, Tang WJ, Seifert R, Schäferling M. A fluorimetric assay for real-time monitoring of adenylyl cyclase activity based on terbium norfloxacin. Analytical Biochemistry. 381: 86-93. PMID 18601890 DOI: 10.1016/J.Ab.2008.06.014 |
0.342 |
|
| 2008 |
Strasser A, Wittmann HJ, Seifert R. Ligand-specific contribution of the N terminus and E2-loop to pharmacological properties of the histamine H1-receptor. The Journal of Pharmacology and Experimental Therapeutics. 326: 783-91. PMID 18577700 DOI: 10.1124/Jpet.108.140913 |
0.31 |
|
| 2008 |
Kleemann P, Papa D, Vigil-Cruz S, Seifert R. Functional reconstitution of the human chemokine receptor CXCR4 with G(i)/G (o)-proteins in Sf9 insect cells. Naunyn-Schmiedebergs Archives of Pharmacology. 378: 261-274. PMID 18523757 DOI: 10.1007/S00210-008-0313-8 |
0.416 |
|
| 2008 |
Pinto C, Papa D, Hübner M, Mou TC, Lushington GH, Seifert R. Activation and inhibition of adenylyl cyclase isoforms by forskolin analogs. The Journal of Pharmacology and Experimental Therapeutics. 325: 27-36. PMID 18184830 DOI: 10.1124/Jpet.107.131904 |
0.806 |
|
| 2007 |
Preuss H, Ghorai P, Kraus A, Dove S, Buschauer A, Seifert R. Point mutations in the second extracellular loop of the histamine H2 receptor do not affect the species-selective activity of guanidine-type agonists. Naunyn-Schmiedeberg's Archives of Pharmacology. 376: 253-64. PMID 17999052 DOI: 10.1007/S00210-007-0204-4 |
0.375 |
|
| 2007 |
Schlegel B, Laggner C, Meier R, Langer T, Schnell D, Seifert R, Stark H, Höltje HD, Sippl W. Generation of a homology model of the human histamine H3 receptor for ligand docking and pharmacophore-based screening Journal of Computer-Aided Molecular Design. 21: 437-453. PMID 17668276 DOI: 10.1007/S10822-007-9127-X |
0.352 |
|
| 2007 |
Göttle M, Dove S, Steindel P, Shen Y, Tang WJ, Geduhn J, König B, Seifert R. Molecular analysis of the interaction of Bordetella pertussis adenylyl cyclase with fluorescent nucleotides Molecular Pharmacology. 72: 526-535. PMID 17553924 DOI: 10.1124/Mol.107.034413 |
0.387 |
|
| 2007 |
Lorenz V, Pinto CS, Seifert R. Complex changes in ecto-nucleoside 5'-triphosphate diphosphohydrolase expression in hypoxanthine phosphoribosyl transferase deficiency. Neuroscience Letters. 420: 6-11. PMID 17459584 DOI: 10.1016/J.Neulet.2007.04.004 |
0.773 |
|
| 2007 |
Preuss H, Ghorai P, Kraus A, Dove S, Buschauer A, Seifert R. Mutations of Cys-17 and Ala-271 in the human histamine H2 receptor determine the species selectivity of guanidine-type agonists and increase constitutive activity. The Journal of Pharmacology and Experimental Therapeutics. 321: 975-82. PMID 17347323 DOI: 10.1124/Jpet.107.120519 |
0.409 |
|
| 2007 |
Preuss H, Ghorai P, Kraus A, Dove S, Buschauer A, Seifert R. Constitutive activity and ligand selectivity of human, guinea pig, rat, and canine histamine H2 receptors. The Journal of Pharmacology and Experimental Therapeutics. 321: 983-95. PMID 17332265 DOI: 10.1124/Jpet.107.120014 |
0.321 |
|
| 2007 |
Wang JL, Guo JX, Zhang QY, Wu JJ, Seifert R, Lushington GH. A conformational transition in the adenylyl cyclase catalytic site yields different binding modes for ribosyl-modified and unmodified nucleotide inhibitors. Bioorganic & Medicinal Chemistry. 15: 2993-3002. PMID 17329110 DOI: 10.1016/J.Bmc.2007.02.014 |
0.364 |
|
| 2007 |
Rottlaender D, Matthes J, Vatner SF, Seifert R, Herzig S. Functional adenylyl cyclase inhibition in murine cardiomyocytes by 2'(3')-O-(N-methylanthraniloyl)-guanosine 5'-[gamma-thio]triphosphate. The Journal of Pharmacology and Experimental Therapeutics. 321: 608-15. PMID 17284671 DOI: 10.1124/Jpet.106.118422 |
0.352 |
|
| 2007 |
Xie SX, Schalkhausser F, Ye QZ, Seifert R, Buschauer A. Effects of impromidine- and arpromidine-derived guanidines on recombinant human and guinea pig histamine H1 and H2 receptors. Archiv Der Pharmazie. 340: 9-16. PMID 17206612 DOI: 10.1002/Ardp.200600140 |
0.386 |
|
| 2006 |
Pertz HH, Görnemann T, Schurad B, Seifert R, Strasser A. Striking differences of action of lisuride stereoisomers at histamine H1 receptors. Naunyn-Schmiedeberg's Archives of Pharmacology. 374: 215-22. PMID 17106670 DOI: 10.1007/S00210-006-0111-0 |
0.331 |
|
| 2006 |
Mou TC, Gille A, Suryanarayana S, Richter M, Seifert R, Sprang SR. Broad specificity of mammalian adenylyl cyclase for interaction with 2',3'-substituted purine- and pyrimidine nucleotide inhibitors. Molecular Pharmacology. 70: 878-86. PMID 16766715 DOI: 10.1124/Mol.106.026427 |
0.72 |
|
| 2006 |
Xie SX, Petrache G, Schneider E, Ye QZ, Bernhardt G, Seifert R, Buschauer A. Synthesis and pharmacological characterization of novel fluorescent histamine H2-receptor ligands derived from aminopotentidine. Bioorganic & Medicinal Chemistry Letters. 16: 3886-90. PMID 16730977 DOI: 10.1016/J.Bmcl.2006.05.039 |
0.354 |
|
| 2006 |
Xie SX, Kraus A, Ghorai P, Ye QZ, Elz S, Buschauer A, Seifert R. N1-(3-cyclohexylbutanoyl)-N2-[3-(1H-imidazol-4-yl)propyl]guanidine (UR-AK57), a potent partial agonist for the human histamine H1- and H2-receptors. The Journal of Pharmacology and Experimental Therapeutics. 317: 1262-8. PMID 16554355 DOI: 10.1124/Jpet.106.102897 |
0.377 |
|
| 2006 |
Pinto CS, Seifert R. Decreased GTP-stimulated adenylyl cyclase activity in HPRT-deficient human and mouse fibroblast and rat B103 neuroblastoma cell membranes. Journal of Neurochemistry. 96: 454-9. PMID 16336632 DOI: 10.1111/J.1471-4159.2005.03570.X |
0.792 |
|
| 2005 |
Kelly JJ, Stevens T, Thompson WJ, Seifert R. Adenylyl and guanylyl cyclase assays. Current Protocols in Pharmacology / Editorial Board, S.J. Enna (Editor-in-Chief) ... [Et Al.]. Unit2.2. PMID 21953389 DOI: 10.1002/0471141755.Ph0202S30 |
0.382 |
|
| 2005 |
Gille A, Guo J, Mou TC, Doughty MB, Lushington GH, Seifert R. Differential interactions of G-proteins and adenylyl cyclase with nucleoside 5'-triphosphates, nucleoside 5'-[gamma-thio]triphosphates and nucleoside 5'-[beta,gamma-imido]triphosphates. Biochemical Pharmacology. 71: 89-97. PMID 16271707 DOI: 10.1016/J.Bcp.2005.10.006 |
0.719 |
|
| 2005 |
Pinto CS, Jinnah HA, Shirley TL, Nyhan WL, Seifert R. Altered membrane NTPase activity in Lesch-Nyhan disease fibroblasts: comparison with HPRT knockout mice and HPRT-deficient cell lines. Journal of Neurochemistry. 93: 1579-86. PMID 15935074 DOI: 10.1111/J.1471-4159.2005.03151.X |
0.788 |
|
| 2005 |
Mou TC, Gille A, Fancy DA, Seifert R, Sprang SR. Structural basis for the inhibition of mammalian membrane adenylyl cyclase by 2 '(3')-O-(N-Methylanthraniloyl)-guanosine 5 '-triphosphate. The Journal of Biological Chemistry. 280: 7253-61. PMID 15591060 DOI: 10.1074/Jbc.M409076200 |
0.706 |
|
| 2005 |
Dove S, Elz S, Seifert R, Buschauer A. Structure-activity relationships of histamine H2 receptor ligands. Mini Reviews in Medicinal Chemistry. 4: 941-54. PMID 15544555 DOI: 10.2174/1389557043403242 |
0.358 |
|
| 2004 |
Gille A, Lushington GH, Mou TC, Doughty MB, Johnson RA, Seifert R. Differential inhibition of adenylyl cyclase isoforms and soluble guanylyl cyclase by purine and pyrimidine nucleotides. The Journal of Biological Chemistry. 279: 19955-69. PMID 14981084 DOI: 10.1074/Jbc.M312560200 |
0.733 |
|
| 2004 |
Gille A, Seifert R. Xanthine nucleotide-specific G-protein alpha-subunits: a novel approach for the analysis of G-protein-mediated signal transduction. Naunyn-Schmiedeberg's Archives of Pharmacology. 369: 141-50. PMID 14654999 DOI: 10.1007/S00210-003-0844-Y |
0.707 |
|
| 2003 |
Menghin S, Pertz HH, Kramer K, Seifert R, Schunack W, Elz S. Nα-Imidazolylalkyl and Pyridylalkyl Derivatives of Histaprodifen: Synthesis and in Vitro Evaluation of Highly Potent Histamine H1-Receptor Agonists Journal of Medicinal Chemistry. 46: 5458-5470. PMID 14640554 DOI: 10.1021/Jm0309147 |
0.326 |
|
| 2003 |
Gille A, Seifert R. MANT-substituted guanine nucleotides: a novel class of potent adenylyl cyclase inhibitors. Life Sciences. 74: 271-9. PMID 14607255 DOI: 10.1016/J.Lfs.2003.09.014 |
0.727 |
|
| 2003 |
Wenzel-Seifert K, Seifert R. Properties of Arg389-β 1 -Adrenoceptor-G sα Fusion Proteins: Comparison with Gly389-β 1 -Adrenoceptor-G sα Fusion Proteins Receptors & Channels. 9: 315-323. PMID 14527875 DOI: 10.3109/713745179 |
0.342 |
|
| 2003 |
Seifert R, Wenzel-Seifert K. The human formyl peptide receptor as model system for constitutively active G-protein-coupled receptors. Life Sciences. 73: 2263-80. PMID 12941430 DOI: 10.1016/S0024-3205(03)00654-4 |
0.416 |
|
| 2003 |
Gille A, Seifert R. Low-affinity interactions of BODIPY-FL-GTPgammaS and BODIPY-FL-GppNHp with G(i)- and G(s)-proteins. Naunyn-Schmiedeberg's Archives of Pharmacology. 368: 210-5. PMID 12920505 DOI: 10.1007/S00210-003-0783-7 |
0.692 |
|
| 2003 |
Gille A, Seifert R. Co-expression of the beta2-adrenoceptor and dopamine D1-receptor with Gsalpha proteins in Sf9 insect cells: limitations in comparison with fusion proteins. Biochimica Et Biophysica Acta. 1613: 101-14. PMID 12832091 DOI: 10.1016/S0005-2736(03)00174-3 |
0.679 |
|
| 2003 |
Wenzel-Seifert K, Seifert R. Functional differences between human formyl peptide receptor isoforms 26, 98, and G6. Naunyn-Schmiedeberg's Archives of Pharmacology. 367: 509-15. PMID 12679864 DOI: 10.1007/S00210-003-0714-7 |
0.397 |
|
| 2003 |
Gille A, Seifert R. 2'(3')-O-(N-methylanthraniloyl)-substituted GTP analogs: a novel class of potent competitive adenylyl cyclase inhibitors. The Journal of Biological Chemistry. 278: 12672-9. PMID 12566433 DOI: 10.1074/Jbc.M211292200 |
0.697 |
|
| 2003 |
Wenzel-Seifert K, Seifert R. Critical role of N-terminal N-glycosylation for proper folding of the human formyl peptide receptor. Biochemical and Biophysical Research Communications. 301: 693-8. PMID 12565836 DOI: 10.1016/S0006-291X(03)00023-8 |
0.418 |
|
| 2003 |
Gille A, Wenzel-Seifert K, Doughty MB, Seifert R. GDP affinity and order state of the catalytic site are critical for function of xanthine nucleotide-selective Galphas proteins. The Journal of Biological Chemistry. 278: 7822-8. PMID 12499374 DOI: 10.1074/Jbc.M210162200 |
0.702 |
|
| 2002 |
Seifert R, Wenzel-Seifert K. Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors. Naunyn-Schmiedeberg's Archives of Pharmacology. 366: 381-416. PMID 12382069 DOI: 10.1007/S00210-002-0588-0 |
0.395 |
|
| 2002 |
Liu HY, Seifert R. Distinct interactions of G(salpha-long), G(salpha-short), and G(alphaolf) with GTP, ITP, and XTP. Biochemical Pharmacology. 64: 583-93. PMID 12167477 DOI: 10.1016/S0006-2952(02)01251-0 |
0.386 |
|
| 2002 |
Gille A, Liu HY, Sprang SR, Seifert R. Distinct interactions of GTP, UTP, and CTP with G(s) proteins. The Journal of Biological Chemistry. 277: 34434-42. PMID 12080068 DOI: 10.1074/Jbc.M204259200 |
0.698 |
|
| 2002 |
Houston C, Wenzel-Seifert K, Bürckstümmer T, Seifert R. The human histamine H2-receptor couples more efficiently to Sf9 insect cell Gs-proteins than to insect cell Gq-proteins: limitations of Sf9 cells for the analysis of receptor/Gq-protein coupling. Journal of Neurochemistry. 80: 678-96. PMID 11841575 DOI: 10.1046/J.0022-3042.2001.00746.X |
0.394 |
|
| 2001 |
Kelley MT, Bürckstümmer T, Wenzel-Seifert K, Dove S, Buschauer A, Seifert R. Distinct interaction of human and guinea pig histamine H2-receptor with guanidine-type agonists. Molecular Pharmacology. 60: 1210-25. PMID 11723228 DOI: 10.1124/Mol.60.6.1210 |
0.399 |
|
| 2001 |
Seifert R, Wenzel-Seifert K. Defective Gi protein coupling in two formyl peptide receptor mutants associated with localized juvenile periodontitis. The Journal of Biological Chemistry. 276: 42043-9. PMID 11559706 DOI: 10.1074/Jbc.M106621200 |
0.371 |
|
| 2001 |
Liu H, Wenzel-Seifert K, Seifert R. The olfactory G protein Gαolf possesses a lower GDP‐affinity and deactivates more rapidly than Gsαshort: consequences for receptor‐coupling and adenylyl cyclase activation Journal of Neurochemistry. 78: 325-338. PMID 11461968 DOI: 10.1046/J.1471-4159.2001.00422.X |
0.465 |
|
| 2000 |
Wenzel-Seifert K, Seifert R. Molecular Analysis of β2-Adrenoceptor Coupling to Gs-, Gi-, and Gq-Proteins Molecular Pharmacology. 58: 954-966. PMID 11040042 DOI: 10.1124/Mol.58.5.954 |
0.349 |
|
| 1999 |
Wenzel-Seifert K, Arthur JM, Liu HY, Seifert R. Quantitative analysis of formyl peptide receptor coupling to g(i)alpha(1), g(i)alpha(2), and g(i)alpha(3). The Journal of Biological Chemistry. 274: 33259-66. PMID 10559200 DOI: 10.1074/Jbc.274.47.33259 |
0.376 |
|
| 1999 |
Lee TW, Seifert R, Guan X, Kobilka BK. Restricting the mobility of Gs alpha: impact on receptor and effector coupling. Biochemistry. 38: 13801-9. PMID 10529225 DOI: 10.1021/Bi9908282 |
0.362 |
|
| 1999 |
Seifert R, Wenzel-Seifert K, Kobilka BK. GPCR-Galpha fusion proteins: molecular analysis of receptor-G-protein coupling. Trends in Pharmacological Sciences. 20: 383-9. PMID 10462762 DOI: 10.1016/S0165-6147(99)01368-1 |
0.352 |
|
| 1999 |
Klinker JF, Seifert R. Interaction of the retinal G-protein transducin with uracil nucleotides. Biochemical and Biophysical Research Communications. 262: 341-5. PMID 10462476 DOI: 10.1006/Bbrc.1999.1203 |
0.403 |
|
| 1999 |
Seifert R, Gether U, Wenzel-Seifert K, Kobilka BK. Effects of guanine, inosine, and xanthine nucleotides on beta(2)-adrenergic receptor/G(s) interactions: evidence for multiple receptor conformations. Molecular Pharmacology. 56: 348-58. PMID 10419554 DOI: 10.1124/Mol.56.2.348 |
0.303 |
|
| 1999 |
Klinker JF, Seifert R. Nucleoside diphosphate kinase activity in soluble transducin preparations biochemical properties and possible role of transducin-beta as phosphorylated enzyme intermediate. European Journal of Biochemistry. 261: 72-80. PMID 10103035 DOI: 10.1046/J.1432-1327.1999.00209.X |
0.38 |
|
| 1999 |
Seifert R, Wenzel-Seifert K, Gether U, Lam VT, Kobilka BK. Examining the efficiency of receptor/G-protein coupling with a cleavable beta2-adrenoceptor-gsalpha fusion protein. European Journal of Biochemistry / Febs. 260: 661-6. PMID 10102993 DOI: 10.1046/J.1432-1327.1999.00161.X |
0.345 |
|
| 1998 |
Wenzel-Seifert K, Lee TW, Seifert R, Kobilka BK. Restricting mobility of Gsalpha relative to the beta2-adrenoceptor enhances adenylate cyclase activity by reducing Gsalpha GTPase activity. The Biochemical Journal. 334: 519-24. PMID 9729456 DOI: 10.1042/Bj3340519 |
0.341 |
|
| 1998 |
Seifert R, Wenzel-Seifert K, Lee TW, Gether U, Sanders-Bush E, Kobilka BK. Different effects of Gsalpha splice variants on beta2-adrenoreceptor-mediated signaling. The beta2-adrenoreceptor coupled to the long splice variant of Gsalpha has properties of a constitutively active receptor. The Journal of Biological Chemistry. 273: 5109-16. PMID 9478963 DOI: 10.1074/Jbc.273.9.5109 |
0.317 |
|
| 1997 |
Klinker JF, Seifert R. Functionally nonequivalent interactions of guanosine 5'-triphosphate, inosine 5'-triphosphate, and xanthosine 5'-triphosphate with the retinal G-protein, transducin, and with Gi-proteins in HL-60 leukemia cell membranes. Biochemical Pharmacology. 54: 551-62. PMID 9337071 DOI: 10.1016/S0006-2952(97)00205-0 |
0.428 |
|
| 1997 |
Wenzel‐Seifert K, Lentzen H, Aktories K, Seifert R. Complex regulation of human neutrophil activation by actin filaments: dihydrocytochalasin B and botulinum C2 toxin uncover the existence of multiple cation entry pathways. Journal of Leukocyte Biology. 61: 703-711. PMID 9201261 DOI: 10.1002/Jlb.61.6.703 |
0.351 |
|
| 1997 |
Klinker JF, Seifert R. Morphine and muscle relaxants are receptor-independent G-protein activators and cromolyn is an inhibitor of stimulated G-protein activity. Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]. 46: 46-50. PMID 9085143 DOI: 10.1007/S000110050058 |
0.372 |
|
| 1996 |
Wenzel-Seifert K, Krautwurst D, Lentzen H, Seifert R. Concanavalin A and mistletoe lectin I differentially activate cation entry and exocytosis in human neutrophils: lectins may activate multiple subtypes of cation channels. Journal of Leukocyte Biology. 60: 345-355. PMID 8830791 DOI: 10.1002/Jlb.60.3.345 |
0.329 |
|
| 1996 |
Klinker JF, Wenzel-Seifert K, Seifert R. G-protein-coupled receptors in HL-60 human leukemia cells. General Pharmacology-the Vascular System. 27: 33-54. PMID 8742493 DOI: 10.1016/0306-3623(95)00107-7 |
0.422 |
|
| 1996 |
Burde R, Seifert R. Stimulation of histamine H2- (and H1)-receptors activates Ca2+ influx in all-atrans-retinoic acid-differentiated HL-60 cells independently of phospholipase C or adenylyl cyclase Naunyn-Schmiedebergs Archives of Pharmacology. 353: 123-129. PMID 8717151 DOI: 10.1007/Bf00168748 |
0.358 |
|
| 1996 |
Wenzel-Seifert K, Krautwurst D, Musgrave I, Seifert R. Thapsigargin activates univalent- and bivalent-cation entry in human neutrophils by a SK&F I3 96365- and Gd3+-sensitive pathway and is a partial secretagogue: involvement of pertussis-toxin-sensitive G-proteins and protein phosphatases 1/2A and 2B in the signal-transduction pathway. Biochemical Journal. 314: 679-686. PMID 8670085 DOI: 10.1042/Bj3140679 |
0.368 |
|
| 1996 |
Burde R, Dippel E, Seifert R. Receptor-independent G protein activation may account for the stimulatory effects of first-generation H1-receptor antagonists in HL-60 cells, basophils, and mast cells Biochemical Pharmacology. 51: 125-131. PMID 8615880 DOI: 10.1016/0006-2952(95)02123-X |
0.413 |
|
| 1996 |
Klinker JF, Laugwitz K, Hagelüken A, Seifert R. Activation of GTP formation and high-affinity GTP hydrolysis by mastoparan in various cell membranes: G-protein activation via nucleoside diphosphate kinase, a possible general mechanism of mastoparan action Biochemical Pharmacology. 51: 217-223. PMID 8573186 DOI: 10.1016/0006-2952(95)02119-1 |
0.417 |
|
| 1996 |
Detert H, Leschke C, Tögel W, Seifert R, Schunacki W. 2-Alkyl-substituted histamines and hydroxyethylimidazoles with G-protein-stimulatory activity European Journal of Medicinal Chemistry. 31: 397-405. DOI: 10.1016/0223-5234(96)89166-5 |
0.438 |
|
| 1995 |
Klinker JF, Hageluken A, Griinbaum L, Seifert R. Direct and indirect receptor-independent G-protein activation by cationic-amphiphilic substances. Studies with mast cells, HL-60 human leukemic cells and purified G-proteins. Experimental Dermatology. 4: 231-239. PMID 8528595 DOI: 10.1111/J.1600-0625.1995.Tb00251.X |
0.427 |
|
| 1995 |
Hagelüken A, Grünbaum L, Klinker JF, Nürnberg B, Harhammer R, Schultz G, Leschke C, Schunack W, Seifert R. Histamine receptor-dependent and/or -independent activation of guanine nucleotide-binding proteins by histamine and 2-substituted histamine derivatives in human leukemia (HL-60) and human erythroleukemia (HEL) cells Biochemical Pharmacology. 49: 901-914. PMID 7741762 DOI: 10.1016/0006-2952(94)00514-M |
0.445 |
|
| 1995 |
Klinker JF, Seifert R. Synthetic lipopeptides activate nucleoside diphosphate kinase in HL-60 membranes. Biochemical and Biophysical Research Communications. 209: 575-81. PMID 7733927 DOI: 10.1006/Bbrc.1995.1539 |
0.335 |
|
| 1995 |
Hagelüken A, Burde R, Nürnberg B, Harhammer R, Buschauer A, Seifert R. Cationic-amphiphilic arpromidine-derived guanidines and a histamine trifluoromethyl-toluidide derivative may activate pertussis toxin-sensitive G-proteins by a receptor-independent mechanism. Naunyn-Schmiedebergs Archives of Pharmacology. 351: 305-308. PMID 7609785 DOI: 10.1007/Bf00233251 |
0.447 |
|
| 1995 |
Schwaner I, Offermanns S, Spicher K, Seifert R, Schultz G. Differential activation of Gi and Gs proteins by E- and I-type prostaglandins in membranes from the human erythroleukaemia cell line, HEL. Biochimica Et Biophysica Acta. 1265: 8-14. PMID 7532011 DOI: 10.1016/0167-4889(94)00198-N |
0.423 |
|
| 1995 |
Musgrave IF, Seifert R. α2A-adrenoceptors mediate activation of non-selective cation channels via Gi-proteins in human erythroleukaemia (HEL) cells: No evidence for a functional role of imidazoline receptors in modulating calcium Biochemical Pharmacology. 49: 187-196. PMID 7530955 DOI: 10.1016/S0006-2952(94)00432-3 |
0.402 |
|
| 1995 |
Detert H, Hagelüken A, Seifert R, Schunack W. 2-Substituted histamines with G-protein-stimulatory activity European Journal of Medicinal Chemistry. 30: 271-276. DOI: 10.1016/0223-5234(96)88235-3 |
0.438 |
|
| 1994 |
Wenzel-Seifert K, Schächtele C, Seifert R. N-Protein Kinase C Isoenzymes May Be Involved in the Regulation of Various Neutrophil Functions Biochemical and Biophysical Research Communications. 200: 1536-1543. PMID 8185608 DOI: 10.1006/Bbrc.1994.1625 |
0.368 |
|
| 1994 |
Naim M, Seifert R, Nürnberg B, Grünbaum L, Schultz G. Some taste substances are direct activators of G-proteins Biochemical Journal. 297: 451-454. PMID 8110180 DOI: 10.1042/Bj2970451 |
0.358 |
|
| 1994 |
Wenzel-Seifert K, Schächtele C, Hummel R, Grünbaum L, Seifert R. Evidence That Inhibition Of Phorbol Ester- Induced Superoxide Anion Formation By Cyclosporin A In Phagocytes Is Not Mediated By Direct Inhibition Of Protein Kinase C Biochemical Pharmacology. 48: 859-864. PMID 8093097 DOI: 10.1016/0006-2952(94)90355-7 |
0.371 |
|
| 1994 |
Seifert R, Grünbaum L, Schultz G. Histamine H1-receptors in HL-60 monocytes are coupled to Gi-proteins and pertussis toxin-insensitive G-proteins and mediate activation of Ca2+ influx without concomitant Ca2+ mobilization from intracellular stores Naunyn-Schmiedebergs Archives of Pharmacology. 349: 355-361. PMID 8058107 DOI: 10.1007/Bf00170880 |
0.352 |
|
| 1994 |
Berg M, Offermanns S, Seifert R, Schultz G. Synthetic lipopeptide Pam3CysSer(Lys)4 is an effective activator of human platelets. The American Journal of Physiology. 266: C1684-91. PMID 8023898 DOI: 10.1152/Ajpcell.1994.266.6.C1684 |
0.329 |
|
| 1994 |
Klinker JF, Hagelüken A, Grünbaum L, Heilmann I, Nürnberg B, Harhammer R, Offermanns S, Schwaner I, Ervens J, Wenzel-Seifert K, Müller T, Seifert R. Mastoparan may activate GTP hydrolysis by Gi-proteins in HL-60 membranes indirectly through interaction with nucleoside diphosphate kinase. Biochemical Journal. 304: 377-383. PMID 7998971 DOI: 10.1042/Bj3040377 |
0.453 |
|
| 1994 |
Klinker JF, Schwaner I, Offermanns S, Hagelüken A, Seifert R. Differential activation of dibutyryl cAMP-differentiated HL-60 human leukemia cells by chemoattractants Biochemical Pharmacology. 48: 1857-1864. PMID 7986196 DOI: 10.1016/0006-2952(94)90583-5 |
0.341 |
|
| 1994 |
Hagelüken A, Grünbaum L, Nürnberg B, Harhammer R, ScHunack W, Seifert R. Lipophilic β-adrenoceptor antagonists and local anesthetics are effective direct activators of g-proteins Biochemical Pharmacology. 47: 1789-1795. PMID 7911302 DOI: 10.1016/0006-2952(94)90307-7 |
0.436 |
|
| 1994 |
Musgrave IF, Seifert R. Human neutrophils and HL-60 cells do not possess α2-adrenoceptors Biochemical Pharmacology. 47: 233-239. PMID 7905732 DOI: 10.1016/0006-2952(94)90011-6 |
0.312 |
|
| 1994 |
Detert H, Hagelüken A, Leschke C, Nümberg B, Seifert R, Schunack W. P88 receptor-independent G-protein activation by 2-substiituted histamines European Journal of Pharmaceutical Sciences. 2: 140. DOI: 10.1016/0928-0987(94)90261-5 |
0.355 |
|
| 1994 |
Nümberg B, Harteneck C, Leopoldt D, Harhammer R, Seifert R, Hagelüken A, Detert H, Schunack W, Hoppe R, Nümberg E. FC19 activation of G-proteins in physiological and reconstituted membranous systems European Journal of Pharmaceutical Sciences. 2: 105. DOI: 10.1016/0928-0987(94)90128-7 |
0.348 |
|
| 1994 |
Klinker J, Hagelüken A, Nürnberg B, Seifert R. SC12 G-protein activation via nucleoside diphosphate kinase European Journal of Pharmaceutical Sciences. 2: 93. DOI: 10.1016/0928-0987(94)90094-9 |
0.345 |
|
| 1993 |
Musgrave IF, Genieser HG, Maronde E, Seifert R. Preparations of Rp-cyclic adenosine 3',5'-phosphorothioate (Rp-cAMPS) can contain biologically active amounts of adenosine. Febs Letters. 318: 227-230. PMID 8382631 DOI: 10.1016/0014-5793(93)80517-X |
0.393 |
|
| 1993 |
Klinker JF, Höer A, Schwaner I, Offermanns S, Wenzel-Seifert K, Seifert R. Lipopeptides activate Gi-proteins in dibutyryl cyclic AMP-differentiated HL-60 cells. Biochemical Journal. 296: 245-251. PMID 8250850 DOI: 10.1042/Bj2960245 |
0.437 |
|
| 1993 |
Wenzel-Seifert K, Seifert R. Partial inhibition of human neutrophil activation by FK-506 at supratherapeutic concentrations. Naunyn-Schmiedeberg's Archives of Pharmacology. 348: 7-13. PMID 7690907 DOI: 10.1007/Bf00168530 |
0.426 |
|
| 1992 |
Wenzel-Seifert K, Ervens J, Seifert R. Differential inhibition and potentiation by cell-permeant analogues of cyclic AMP and cyclic GMP and NO-containing compounds of exocytosis in human neutrophils. Naunyn-Schmiedeberg's Archives of Pharmacology. 344: 396-402. PMID 1722562 DOI: 10.1007/Bf00172578 |
0.305 |
|
| 1992 |
Klinz F, Seifert R, Schwaner I, Gausepohl H, Frank R, Schultz G. Generation of specific antibodies against the rap1A, rap1B and rap2 small GTP-binding proteins. Analysis of rap and ras proteins in membranes from mammalian cells. Febs Journal. 207: 207-213. PMID 1628649 DOI: 10.1111/J.1432-1033.1992.Tb17039.X |
0.351 |
|
| 1992 |
Ervens J, Seifert R. Molsidomine inhibits the chemoattractant-induced respiratory burst in human neutrophils via a no-independent mechanism. Biochemical Pharmacology. 44: 637-644. PMID 1324680 DOI: 10.1016/0006-2952(92)90397-2 |
0.372 |
|
| 1992 |
Offermanns S, Seifert R, Metzger JW, Jung G, Lieberknecht A, Schmidt U, Schultz G. Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells. Biochemical Journal. 282: 551-557. PMID 1312332 DOI: 10.1042/Bj2820551 |
0.322 |
|
| 1992 |
Seifert R, Serke S, Huhn D, Bessler WG, Hauschildt S, Metzger J, Wiesmüller K, Jung G. Incomplete functional differentiation of HL‐60 leukemic cells by synthetic lipopetides Febs Journal. 203: 143-151. PMID 1309696 DOI: 10.1111/J.1432-1033.1992.Tb19839.X |
0.395 |
|
| 1992 |
Krautwurst D, Seifert R, Hescheler J, Schultz G. Formyl peptides and ATP stimulate Ca2+ and Na+ inward currents through non-selective cation channels via G-proteins in dibutyryl cyclic AMP-differentiated HL-60 cells. Involvement of Ca2+ and Na+ in the activation of beta-glucuronidase release and superoxide production. Biochemical Journal. 288: 1025-1035. PMID 1281979 DOI: 10.1042/Bj2881025 |
0.315 |
|
| 1991 |
Seifert R, Hilgenstock G, Fassbender M, Distler A. Regulation of the superoxide-forming NADPH oxidase of human neutrophils is not altered in essential hypertension. Journal of Hypertension. 9: 147-153. PMID 1849530 DOI: 10.1097/00004872-199102000-00008 |
0.343 |
|
| 1991 |
Ervens J, Seifert R. Differential modulation by N4, 2'-O-dibutyryl cytidine 3':5'-cyclic monophosphate of neutrophil activation. Biochemical and Biophysical Research Communications. 174: 258-267. PMID 1703410 DOI: 10.1016/0006-291X(91)90514-8 |
0.316 |
|
| 1991 |
Ervens J, Schultz G, Seifert R. Differential inhibition and potentiation of chemoattractant-induced superoxide formation in human neutrophils by the cell-permeant analogue of cyclic GMP, N2,2'-O-dibutyryl guanosine 3':5'-cyclic monophosphate. Naunyn-Schmiedebergs Archives of Pharmacology. 343: 370-376. PMID 1649410 DOI: 10.1007/Bf00179041 |
0.319 |
|
| 1991 |
Ervens J, Schultz G, Seifert R. Differential regulation of chemoattractant-induced superoxide formation in human neutrophils by cell-permeant analogues of cyclic AMP and cyclic GMP. Biochemical Society Transactions. 19: 59-63. PMID 1645316 DOI: 10.1042/Bst0190059 |
0.313 |
|
| 1990 |
Seifert R, Schultz G, Richter-Freund M, Metzger J, Wiesmüller KH, Jung G, Bessler WG, Hauschildt S. Activation of superoxide formation and lysozyme release in human neutrophils by the synthetic lipopeptide Pam3Cys-Ser-(Lys)4. Involvement of guanine-nucleotide-binding proteins and synergism with chemotactic peptides. Biochemical Journal. 267: 795-802. PMID 2160237 DOI: 10.1042/Bj2670795 |
0.379 |
|
| 1990 |
Wenzel-Seifert K, Seifert R. Nucleotide-, Chemotactic Peptide- and Phorbol Ester-Induced Exocytosis in HL-60 Leukemic Cells Immunobiology. 181: 298-316. PMID 1966023 DOI: 10.1016/S0171-2985(11)80499-7 |
0.395 |
|
| 1990 |
Burde R, Buschauer A, Seifert R. Characterization of histamine H2-receptors in human neutrophils with a series of guanidine analogues of impromidine. Are cell type-specific H2-receptors involved in the regulation of NADPH oxidase? Naunyn-Schmiedeberg's Archives of Pharmacology. 341: 455-61. PMID 1694972 DOI: 10.1007/Bf00176340 |
0.359 |
|
| 1989 |
Seifert R, Schultz G. Involvement of pyrimidinoceptors in the regulation of cell functions by uridine and by uracil nucleotides. Trends in Pharmacological Sciences. 10: 365-369. PMID 2690427 DOI: 10.1016/0165-6147(89)90009-6 |
0.401 |
|
| 1989 |
Burde R, Seifert R, Buschauer A, Schultz G. Histamine inhibits activation of human neutrophils and HL-60 leukemic cells via H2-receptors. Naunyn-Schmiedebergs Archives of Pharmacology. 340: 671-678. PMID 2559336 DOI: 10.1007/Bf00717743 |
0.392 |
|
| 1989 |
Seifert R, Burde R, Schultz G. Lack of effect of opioid peptides, morphine and naloxone on superoxide formation in human neutrophils and HL-60 leukemic cells. Naunyn-Schmiedebergs Archives of Pharmacology. 340: 101-106. PMID 2552328 DOI: 10.1007/Bf00169214 |
0.306 |
|
| 1989 |
Seifert R, Burde R, Schultz G. Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptides Biochemical Journal. 259: 813-819. PMID 2543370 DOI: 10.1042/Bj2590813 |
0.411 |
|
| 1989 |
Seifert R, Wenzel K, Eckstein F, Schultz G. Purine and pyrimidine nucleotides potentiate activation of NADPH oxidase and degranulation by chemotactic peptides and induce aggregation of human neutrophils via G proteins. European Journal of Biochemistry. 181: 277-85. PMID 2540969 DOI: 10.1111/J.1432-1033.1989.Tb14722.X |
0.357 |
|
| 1989 |
Rudolph U, Koesling D, Hinsch KD, Seifert R, Bigalke M, Schultz G, Rosenthal W. G-protein alpha-subunits in cytosolic and membranous fractions of human neutrophils. Molecular and Cellular Endocrinology. 63: 143-53. PMID 2502457 DOI: 10.1016/0303-7207(89)90090-7 |
0.361 |
|
| 1989 |
Seifert R, Jungblut P, Schultz G. Differential expression of cytosolic activation factors for NADPH oxidase in HL-60 leukemic cells Biochemical and Biophysical Research Communications. 161: 1109-1117. PMID 2472788 DOI: 10.1016/0006-291X(89)91357-0 |
0.347 |
|
| 1988 |
Seifert R, Schächtele C, Rosenthal W, Schultz G. Activation of protein kinase C by cis- and trans-fatty acids and its potentiation by diacylglycerol Biochemical and Biophysical Research Communications. 154: 20-26. PMID 3395325 DOI: 10.1016/0006-291X(88)90643-2 |
0.303 |
|
| 1988 |
Norgauer J, Kownatzki E, Seifert R, Aktories K. Botulinum C2 toxin ADP-ribosylates actin and enhances O2- production and secretion but inhibits migration of activated human neutrophils. Journal of Clinical Investigation. 82: 1376-1382. PMID 2844854 DOI: 10.1172/Jci113741 |
0.342 |
|
| 1988 |
Seifert R, Rosenthal W, Schultz G, Wieland T, Gierschick P, Jakobs KH. The role of nucleoside-diphosphate kinase reactions in G protein activation of NADPH oxidase by guanine and adenine nucleotides Febs Journal. 175: 51-55. PMID 2841126 DOI: 10.1111/J.1432-1033.1988.Tb14165.X |
0.374 |
|
| 1988 |
Seifert R, Schächtele C. Studies with protein kinase C inhibitors presently available cannot elucidate the role of protein kinase C in the activation of NADPH oxidase Biochemical and Biophysical Research Communications. 152: 585-592. PMID 2835037 DOI: 10.1016/S0006-291X(88)80078-0 |
0.382 |
|
| 1988 |
Schächtele C, Seifert R, Osswald H. Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine. Biochemical and Biophysical Research Communications. 151: 542-547. PMID 2831891 DOI: 10.1016/0006-291X(88)90628-6 |
0.341 |
|
| 1987 |
Seifert R, Schultz G. Fatty‐acid‐induced activation of NADPH oxidase in plasma membranes of human neutrophils depends on neutrophil cytosol and is potentiated by stable guanine nucleotides Febs Journal. 162: 563-569. PMID 3549290 DOI: 10.1111/J.1432-1033.1987.Tb10676.X |
0.374 |
|
| 1987 |
Seifert R, Schultz G. Reversible activation of NADPH oxidase in membranes of HL-60 human leukemic cells Biochemical and Biophysical Research Communications. 146: 1296-1302. PMID 3113431 DOI: 10.1016/0006-291X(87)90790-X |
0.368 |
|
| 1986 |
Seifert R, Rosenthal W, Schultz G. Guanine nucleotides stimulate NADPH oxidase in membranes of human neutrophils Febs Letters. 205: 161-165. PMID 3017756 DOI: 10.1016/0014-5793(86)80886-9 |
0.389 |
|
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