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Francisco Asturias - Publications

Affiliations: 
Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Cell Biology, General Biophysics
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42 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Zhao H, Li J, Xiang Y, Malik S, Vartak SV, Veronezi GMB, Young N, Riney M, Kalchschmidt J, Conte A, Jung SK, Ramachandran S, Roeder RG, Shi Y, Casellas R, ... Asturias FJ, et al. An IDR-dependent mechanism for nuclear receptor control of Mediator interaction with RNA polymerase II. Molecular Cell. PMID 38955181 DOI: 10.1016/j.molcel.2024.06.006  0.367
2021 Zhao H, Young N, Kalchschmidt J, Lieberman J, El Khattabi L, Casellas R, Asturias FJ. Structure of mammalian Mediator complex reveals Tail module architecture and interaction with a conserved core. Nature Communications. 12: 1355. PMID 33649303 DOI: 10.1038/s41467-021-21601-w  0.451
2019 El Khattabi L, Zhao H, Kalchschmidt J, Young N, Jung S, Van Blerkom P, Kieffer-Kwon P, Kieffer-Kwon KR, Park S, Wang X, Krebs J, Tripathi S, Sakabe N, Sobreira DR, Huang SC, ... ... Asturias FJ, et al. A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers. Cell. PMID 31402173 DOI: 10.1016/J.Cell.2019.07.011  0.407
2018 Brignole EJ, Tsai KL, Chittuluru J, Li H, Aye Y, Penczek PA, Stubbe J, Drennan CL, Asturias F. 3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound. Elife. 7. PMID 29460780 DOI: 10.7554/Elife.31502  0.758
2017 Tsai KL, Yu X, Gopalan S, Chao TC, Zhang Y, Florens L, Washburn MP, Murakami K, Conaway RC, Conaway JW, Asturias FJ. Mediator structure and rearrangements required for holoenzyme formation. Nature. PMID 28241144 DOI: 10.1038/Nature21393  0.668
2016 Sato S, Tomomori-Sato C, Tsai KL, Yu X, Sardiu M, Saraf A, Washburn MP, Florens L, Asturias FJ, Conaway RC, Conaway JW. Role for the MED21-MED7 Hinge in Assembly of the Mediator-RNA Polymerase II Holoenzyme. The Journal of Biological Chemistry. PMID 27821593 DOI: 10.1074/Jbc.M116.756098  0.571
2015 Murakami K, Tsai KL, Kalisman N, Bushnell DA, Asturias FJ, Kornberg RD. Structure of an RNA polymerase II preinitiation complex. Proceedings of the National Academy of Sciences of the United States of America. 112: 13543-8. PMID 26483468 DOI: 10.1073/pnas.1518255112  0.395
2014 Tsai KL, Tomomori-Sato C, Sato S, Conaway RC, Conaway JW, Asturias FJ. Subunit Architecture and Functional Modular Rearrangements of the Transcriptional Mediator Complex. Cell. 158: 463. PMID 28915369 DOI: 10.1016/j.cell.2014.06.036  0.586
2014 Tsai KL, Tomomori-Sato C, Sato S, Conaway RC, Conaway JW, Asturias FJ. Subunit architecture and functional modular rearrangements of the transcriptional mediator complex. Cell. 157: 1430-44. PMID 24882805 DOI: 10.1016/J.Cell.2014.05.015  0.68
2013 Tsai KL, Sato S, Tomomori-Sato C, Conaway RC, Conaway JW, Asturias FJ. A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction. Nature Structural & Molecular Biology. 20: 611-9. PMID 23563140 DOI: 10.1038/Nsmb.2549  0.63
2013 Minnihan EC, Ando N, Brignole EJ, Olshansky L, Chittuluru J, Asturias FJ, Drennan CL, Nocera DG, Stubbe J. Generation of a stable, aminotyrosyl radical-induced α2β2 complex of Escherichia coli class Ia ribonucleotide reductase. Proceedings of the National Academy of Sciences of the United States of America. 110: 3835-40. PMID 23431160 DOI: 10.1073/Pnas.1220691110  0.733
2012 Aye Y, Brignole EJ, Long MJ, Chittuluru J, Drennan CL, Asturias FJ, Stubbe J. Clofarabine targets the large subunit (α) of human ribonucleotide reductase in live cells by assembly into persistent hexamers. Chemistry & Biology. 19: 799-805. PMID 22840768 DOI: 10.1016/J.Chembiol.2012.05.015  0.748
2012 Yang Z, Fang J, Chittuluru J, Asturias FJ, Penczek PA. Iterative stable alignment and clustering of 2D transmission electron microscope images. Structure (London, England : 1993). 20: 237-47. PMID 22325773 DOI: 10.1016/J.Str.2011.12.007  0.715
2012 Gibbons BJ, Brignole EJ, Azubel M, Murakami K, Voss NR, Bushnell DA, Asturias FJ, Kornberg RD. Subunit architecture of general transcription factor TFIIH. Proceedings of the National Academy of Sciences of the United States of America. 109: 1949-54. PMID 22308316 DOI: 10.1073/Pnas.1105266109  0.459
2011 Ando N, Brignole EJ, Zimanyi CM, Funk MA, Yokoyama K, Asturias FJ, Stubbe J, Drennan CL. Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase. Proceedings of the National Academy of Sciences of the United States of America. 108: 21046-51. PMID 22160671 DOI: 10.1073/Pnas.1112715108  0.354
2011 Wang W, Perovic I, Chittuluru J, Kaganovich A, Nguyen LT, Liao J, Auclair JR, Johnson D, Landeru A, Simorellis AK, Ju S, Cookson MR, Asturias FJ, Agar JN, Webb BN, et al. A soluble α-synuclein construct forms a dynamic tetramer. Proceedings of the National Academy of Sciences of the United States of America. 108: 17797-802. PMID 22006323 DOI: 10.1073/Pnas.1113260108  0.741
2011 Chittuluru JR, Chaban Y, Monnet-Saksouk J, Carrozza MJ, Sapountzi V, Selleck W, Huang J, Utley RT, Cramet M, Allard S, Cai G, Workman JL, Fried MG, Tan S, Côté J, ... Asturias FJ, et al. Structure and nucleosome interaction of the yeast NuA4 and Piccolo-NuA4 histone acetyltransferase complexes. Nature Structural & Molecular Biology. 18: 1196-203. PMID 21984211 DOI: 10.1038/Nsmb.2128  0.761
2011 Imasaki T, Calero G, Cai G, Tsai KL, Yamada K, Cardelli F, Erdjument-Bromage H, Tempst P, Berger I, Kornberg GL, Asturias FJ, Kornberg RD, Takagi Y. Architecture of the Mediator head module. Nature. 475: 240-3. PMID 21725323 DOI: 10.1038/nature10162  0.42
2010 Brignole EJ, Asturias F. Single-particle electron microscopy of animal fatty acid synthase describing macromolecular rearrangements that enable catalysis. Methods in Enzymology. 483: 179-202. PMID 20888475 DOI: 10.1016/S0076-6879(10)83009-5  0.318
2010 Lee JH, Cai G, Panigrahi AK, Dunham-Ems S, Nguyen TN, Radolf JD, Asturias FJ, Günzl A. A TFIIH-associated mediator head is a basal factor of small nuclear spliced leader RNA gene transcription in early-diverged trypanosomes. Molecular and Cellular Biology. 30: 5502-13. PMID 20876299 DOI: 10.1128/Mcb.00966-10  0.364
2010 Opalka N, Brown J, Lane WJ, Twist KA, Landick R, Asturias FJ, Darst SA. Complete structural model of Escherichia coli RNA polymerase from a hybrid approach. Plos Biology. 8. PMID 20856905 DOI: 10.1371/Journal.Pbio.1000483  0.304
2010 Cai G, Imasaki T, Yamada K, Cardelli F, Takagi Y, Asturias FJ. Mediator head module structure and functional interactions. Nature Structural & Molecular Biology. 17: 273-9. PMID 20154708 DOI: 10.1038/nsmb.1757  0.351
2009 Cai G, Imasaki T, Takagi Y, Asturias FJ. Mediator structural conservation and implications for the regulation mechanism. Structure (London, England : 1993). 17: 559-67. PMID 19368889 DOI: 10.1016/j.str.2009.01.016  0.444
2008 Chaban Y, Ezeokonkwo C, Chung WH, Zhang F, Kornberg RD, Maier-Davis B, Lorch Y, Asturias FJ. Structure of a RSC-nucleosome complex and insights into chromatin remodeling. Nature Structural & Molecular Biology. 15: 1272-7. PMID 19029894 DOI: 10.1038/nsmb.1524  0.316
2008 Fuxreiter M, Tompa P, Simon I, Uversky VN, Hansen JC, Asturias FJ. Malleable machines take shape in eukaryotic transcriptional regulation. Nature Chemical Biology. 4: 728-37. PMID 19008886 DOI: 10.1038/Nchembio.127  0.371
2007 Chaban Y, Brown J, Lorch Y, Kornberg R, Asturias F. Macromolecular Electron Microscopy Studies of the Eukaryotic Transcription Machinery Microscopy and Microanalysis. 13. DOI: 10.1017/S1431927607075149  0.372
2006 Takagi Y, Calero G, Komori H, Brown JA, Ehrensberger AH, Hudmon A, Asturias F, Kornberg RD. Head module control of mediator interactions. Molecular Cell. 23: 355-64. PMID 16885025 DOI: 10.1016/J.Molcel.2006.06.007  0.461
2005 Chadick JZ, Asturias FJ. Structure of eukaryotic Mediator complexes. Trends in Biochemical Sciences. 30: 264-71. PMID 15896745 DOI: 10.1016/j.tibs.2005.03.001  0.439
2004 Bourbon HM, Aguilera A, Ansari AZ, Asturias FJ, Berk AJ, Bjorklund S, Blackwell TK, Borggrefe T, Carey M, Carlson M, Conaway JW, Conaway RC, Emmons SW, Fondell JD, Freedman LP, et al. A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Molecular Cell. 14: 553-7. PMID 15175151 DOI: 10.1016/J.Molcel.2004.05.011  0.62
2004 Asturias FJ. RNA polymerase II structure, and organization of the preinitiation complex. Current Opinion in Structural Biology. 14: 121-9. PMID 15093825 DOI: 10.1016/j.sbi.2004.03.007  0.428
2004 Asturias FJ, Ezeokonkwo C, Kornberg RD, Lorch Y. Electron microscopic analysis of the RSC chromatin remodeling complex. Methods in Enzymology. 376: 48-62. PMID 14975298 DOI: 10.1016/S0076-6879(03)76004-2  0.352
2003 Chung WH, Craighead JL, Chang WH, Ezeokonkwo C, Bareket-Samish A, Kornberg RD, Asturias FJ. RNA polymerase II/TFIIF structure and conserved organization of the initiation complex. Molecular Cell. 12: 1003-13. PMID 14580350 DOI: 10.1016/S1097-2765(03)00387-3  0.775
2003 Asturias FJ, Craighead JL. RNA polymerase II at initiation. Proceedings of the National Academy of Sciences of the United States of America. 100: 6893-5. PMID 12782794 DOI: 10.1073/Pnas.1332606100  0.773
2002 Davis JA, Takagi Y, Kornberg RD, Asturias FA. Structure of the yeast RNA polymerase II holoenzyme: Mediator conformation and polymerase interaction. Molecular Cell. 10: 409-15. PMID 12191485 DOI: 10.1016/S1097-2765(02)00598-1  0.472
2002 Craighead JL, Chang WH, Asturias FJ. Structure of yeast RNA polymerase II in solution: implications for enzyme regulation and interaction with promoter DNA. Structure (London, England : 1993). 10: 1117-25. PMID 12176389 DOI: 10.1016/S0969-2126(02)00813-4  0.772
2002 Asturias FJ, Kornberg RD, Craighead JL, Davis JA, Chang W. Structure of the Eukaryotic Transcription Machinery: Insights into the Mechanism of Transcription Initiation and Regulation Microscopy and Microanalysis. 8: 202-203. DOI: 10.1017/S1431927602100018  0.741
2000 Dotson MR, Yuan CX, Roeder RG, Myers LC, Gustafsson CM, Jiang YW, Li Y, Kornberg RD, Asturias FJ. Structural organization of yeast and mammalian mediator complexes. Proceedings of the National Academy of Sciences of the United States of America. 97: 14307-10. PMID 11114191 DOI: 10.1073/Pnas.260489497  0.343
1999 Asturias FJ, Kornberg RD. Protein crystallization on lipid layers and structure determination of the RNA polymerase II transcription initiation complex. The Journal of Biological Chemistry. 274: 6813-6. PMID 10066729 DOI: 10.1074/jbc.274.11.6813  0.326
1999 Asturias FJ, Jiang YW, Myers LC, Gustafsson CM, Kornberg RD. Conserved structures of mediator and RNA polymerase II holoenzyme. Science (New York, N.Y.). 283: 985-7. PMID 9974391 DOI: 10.1126/Science.283.5404.985  0.417
1998 Asturias FJ, Chang W, Li Y, Kornberg RD. Electron crystallography of yeast RNA polymerase II preserved in vitreous ice. Ultramicroscopy. 70: 133-43. PMID 9499590 DOI: 10.1016/S0304-3991(97)00108-3  0.331
1997 Asturias FJ, Meredith GD, Poglitsch CL, Kornberg RD. Two conformations of RNA polymerase II revealed by electron crystallography. Journal of Molecular Biology. 272: 536-40. PMID 9325110 DOI: 10.1006/jmbi.1997.1273  0.39
1990 Blasie JK, Pascolini D, Asturias F, Herbette LG, Pierce D, Scarpa A. Large-scale structural changes in the sarcoplasmic reticulum ATPase appear essential for calcium transport. Biophysical Journal. 58: 687-93. PMID 2145042 DOI: 10.1016/S0006-3495(90)82411-5  0.326
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